IGHMBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)4.34814129
2IMP biosynthetic process (GO:0006188)4.32129275
3telomere maintenance via semi-conservative replication (GO:0032201)4.23303293
4DNA strand elongation involved in DNA replication (GO:0006271)4.21356553
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17428412
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17428412
7DNA strand elongation (GO:0022616)4.09845314
8nucleobase biosynthetic process (GO:0046112)4.09185132
9protein localization to kinetochore (GO:0034501)4.07211987
10NIK/NF-kappaB signaling (GO:0038061)4.02994799
11maturation of SSU-rRNA (GO:0030490)3.91376811
12ribosomal small subunit assembly (GO:0000028)3.89745375
13positive regulation of tolerance induction (GO:0002645)3.83126620
14DNA unwinding involved in DNA replication (GO:0006268)3.78724015
15cell-cell junction maintenance (GO:0045217)3.78012759
16establishment of apical/basal cell polarity (GO:0035089)3.68916493
17DNA replication checkpoint (GO:0000076)3.67868685
18formation of translation preinitiation complex (GO:0001731)3.66931874
19regulation of translation in response to stress (GO:0043555)3.66464249
20folic acid-containing compound biosynthetic process (GO:0009396)3.63172510
21peptidyl-arginine omega-N-methylation (GO:0035247)3.61381265
22histone H2A acetylation (GO:0043968)3.61175858
23DNA replication-dependent nucleosome organization (GO:0034723)3.58563890
24DNA replication-dependent nucleosome assembly (GO:0006335)3.58563890
25IMP metabolic process (GO:0046040)3.57297312
26telomere maintenance via recombination (GO:0000722)3.55517503
27mitotic nuclear envelope disassembly (GO:0007077)3.54516529
28base-excision repair, AP site formation (GO:0006285)3.53679806
29establishment or maintenance of monopolar cell polarity (GO:0061339)3.52867459
30establishment of monopolar cell polarity (GO:0061162)3.52867459
31nuclear pore organization (GO:0006999)3.52586141
32regulation of B cell apoptotic process (GO:0002902)3.51657366
33heterochromatin organization (GO:0070828)3.49367884
34negative regulation of B cell apoptotic process (GO:0002903)3.46541795
35positive regulation of Cdc42 GTPase activity (GO:0043089)3.45382484
36telomere maintenance via telomere lengthening (GO:0010833)3.39406612
37ribosome biogenesis (GO:0042254)3.38893275
38DNA synthesis involved in DNA repair (GO:0000731)3.37325228
39negative regulation of immunoglobulin mediated immune response (GO:0002890)3.34354477
40negative regulation of B cell mediated immunity (GO:0002713)3.34354477
41negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.33334232
42pre-miRNA processing (GO:0031054)3.33310240
43antigen processing and presentation of endogenous antigen (GO:0019883)3.33104568
44negative regulation of metanephros development (GO:0072217)3.32296267
45mitotic recombination (GO:0006312)3.32086984
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30083229
47immunoglobulin mediated immune response (GO:0016064)3.28947539
48pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.27075355
49UMP metabolic process (GO:0046049)3.27075355
50pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.27075355
51UMP biosynthetic process (GO:0006222)3.27075355
52diaphragm development (GO:0060539)3.26880287
53nuclear envelope disassembly (GO:0051081)3.25895990
54membrane disassembly (GO:0030397)3.25895990
55negative regulation of T cell differentiation in thymus (GO:0033085)3.25791818
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.24779272
57nuclear pore complex assembly (GO:0051292)3.24518866
58protein localization to chromosome, centromeric region (GO:0071459)3.24371916
59purine nucleobase biosynthetic process (GO:0009113)3.23981609
60positive regulation of histone deacetylation (GO:0031065)3.22438164
61* DNA duplex unwinding (GO:0032508)3.21439647
62mannose metabolic process (GO:0006013)3.21135731
63ubiquinone biosynthetic process (GO:0006744)3.21015004
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.19228607
65translesion synthesis (GO:0019985)3.19094153
66* DNA geometric change (GO:0032392)3.18766819
67viral transcription (GO:0019083)3.17527335
68DNA replication-independent nucleosome assembly (GO:0006336)3.16401422
69DNA replication-independent nucleosome organization (GO:0034724)3.16401422
70pyrimidine-containing compound salvage (GO:0008655)3.15851365
71pyrimidine nucleoside salvage (GO:0043097)3.15851365
72ribosomal small subunit biogenesis (GO:0042274)3.15280544
73snRNA metabolic process (GO:0016073)3.15041760
74spliceosomal snRNP assembly (GO:0000387)3.13746212
75chromatin remodeling at centromere (GO:0031055)3.13416127
76regulation of tolerance induction (GO:0002643)3.13203284
77mitotic sister chromatid segregation (GO:0000070)3.12747674
78regulation of interferon-gamma biosynthetic process (GO:0045072)3.12696498
79negative regulation of DNA-templated transcription, elongation (GO:0032785)3.12281721
80snRNA processing (GO:0016180)3.11345184
81ribosome assembly (GO:0042255)3.09253295
82histone arginine methylation (GO:0034969)3.08535658
83negative regulation of telomere maintenance (GO:0032205)3.08380041
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.08239519
85peptidyl-arginine N-methylation (GO:0035246)3.07585251
86peptidyl-arginine methylation (GO:0018216)3.07585251
87negative regulation of erythrocyte differentiation (GO:0045647)3.07337454
88translational termination (GO:0006415)3.06900929
89tolerance induction (GO:0002507)3.06792252
90ribonucleoprotein complex biogenesis (GO:0022613)3.06751196
91pseudouridine synthesis (GO:0001522)3.06077955
92germinal center formation (GO:0002467)3.05256691
93ncRNA 3-end processing (GO:0043628)3.04917526
94cell junction maintenance (GO:0034331)3.03696765
95negative regulation of interleukin-12 production (GO:0032695)3.01868989
96negative regulation of RNA splicing (GO:0033119)3.01559070
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01518834
98DNA deamination (GO:0045006)3.00913889
99negative regulation of cell size (GO:0045792)2.99196009
100positive regulation of gamma-delta T cell activation (GO:0046645)2.99089626
101skeletal muscle organ development (GO:0060538)2.97747307
102positive regulation of protein deacetylation (GO:0090312)2.97309523
103CENP-A containing nucleosome assembly (GO:0034080)2.96575249
104chromatin assembly or disassembly (GO:0006333)2.94603809
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.93950132
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93936324
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92671732
108regulation of translational fidelity (GO:0006450)2.92111047
109N-acetylneuraminate metabolic process (GO:0006054)2.89791280
110translational elongation (GO:0006414)2.89739103
111mRNA splicing, via spliceosome (GO:0000398)2.89517201
112RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89517201
113regulation of chromatin binding (GO:0035561)2.88348329
114rRNA processing (GO:0006364)2.88262057
115regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88233503
116sister chromatid segregation (GO:0000819)2.88093405
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87672885
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.87672885
119modulation by symbiont of host immune response (GO:0052553)2.87672885
120positive regulation by symbiont of host defense response (GO:0052509)2.87672885
121modulation by symbiont of host defense response (GO:0052031)2.87672885
122modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87672885
123cellular response to exogenous dsRNA (GO:0071360)2.87441270
124histone H3-K4 trimethylation (GO:0080182)2.87361471
125RNA splicing, via transesterification reactions (GO:0000375)2.87158890
126cellular response to gonadotropin stimulus (GO:0071371)2.87091133
127negative regulation of histone methylation (GO:0031061)2.86505785
128mitotic metaphase plate congression (GO:0007080)2.84958466
129response to protozoan (GO:0001562)2.83403342
130mitotic sister chromatid cohesion (GO:0007064)2.82466670
131negative regulation of translational initiation (GO:0045947)2.82061699
132translational initiation (GO:0006413)2.82004244
133regulation of gamma-delta T cell activation (GO:0046643)2.81622852
134response to type I interferon (GO:0034340)2.81422322
135kinetochore organization (GO:0051383)2.81080384
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80926313
137regulation of spindle organization (GO:0090224)2.80088654
138mitotic chromosome condensation (GO:0007076)2.79830225
139negative regulation of mRNA processing (GO:0050686)2.79608313
140positive regulation of isotype switching (GO:0045830)2.79356108
141protein localization to chromosome (GO:0034502)2.78490637
142telomere maintenance (GO:0000723)2.78482631
143positive regulation of histone H3-K4 methylation (GO:0051571)2.78385505
144postreplication repair (GO:0006301)2.78165111
145termination of RNA polymerase II transcription (GO:0006369)2.78148163
146ubiquinone metabolic process (GO:0006743)2.77459169
147regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77426419
148telomere organization (GO:0032200)2.77114033
149negative regulation of viral release from host cell (GO:1902187)2.76674063
150rRNA metabolic process (GO:0016072)2.76250783
151chaperone mediated protein folding requiring cofactor (GO:0051085)2.73749353
152mitochondrial DNA metabolic process (GO:0032042)2.72746977
153response to peptidoglycan (GO:0032494)2.72508814
154defense response to protozoan (GO:0042832)2.71880277
155negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.70921791
156macrophage activation involved in immune response (GO:0002281)2.68676530
157nucleotide salvage (GO:0043173)2.67701339
158pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.67535444
159negative regulation of innate immune response (GO:0045824)2.65864158
160regulation of cell proliferation involved in kidney development (GO:1901722)2.65240966
161negative regulation of tumor necrosis factor production (GO:0032720)2.64889094
162metallo-sulfur cluster assembly (GO:0031163)2.64667999
163iron-sulfur cluster assembly (GO:0016226)2.64667999
164type I interferon signaling pathway (GO:0060337)2.63685661
165cellular response to type I interferon (GO:0071357)2.63685661
166pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.60131195
167regulation of isotype switching to IgG isotypes (GO:0048302)2.59163251
168negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.58887740
169negative regulation of interleukin-6 production (GO:0032715)2.57019778
170positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53324005
171positive regulation of triglyceride biosynthetic process (GO:0010867)2.51531037
172positive regulation of DNA recombination (GO:0045911)2.51092433
173short-chain fatty acid metabolic process (GO:0046459)2.50537167
174mitotic G1/S transition checkpoint (GO:0044819)2.49584639
175regulation of ARF GTPase activity (GO:0032312)2.48330214
176response to muramyl dipeptide (GO:0032495)2.47765058
177negative regulation of interleukin-8 production (GO:0032717)2.47754601
178interferon-gamma secretion (GO:0072643)2.46438990
179regulation of MHC class I biosynthetic process (GO:0045343)2.44619059
180quinone biosynthetic process (GO:1901663)2.44571690
181CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.43243447
182lipopolysaccharide biosynthetic process (GO:0009103)2.39724921
183nucleoside salvage (GO:0043174)2.39541855
184lipopolysaccharide metabolic process (GO:0008653)2.38056447
185negative regulation of cAMP-mediated signaling (GO:0043951)2.34676825
186lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34020149
187mitochondrial calcium ion transport (GO:0006851)2.33580525
188T-helper cell differentiation (GO:0042093)2.31099835
189CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.31099835
190negative regulation of T cell mediated immunity (GO:0002710)2.27692882
191regulation of interferon-beta production (GO:0032648)2.27608930
192neuromuscular process controlling posture (GO:0050884)2.27114271
193negative regulation of histone acetylation (GO:0035067)2.26834440
194opioid receptor signaling pathway (GO:0038003)2.26415399
195positive regulation of histone acetylation (GO:0035066)2.26264215
196CD4-positive, alpha-beta T cell activation (GO:0035710)2.24932475
197melanin biosynthetic process (GO:0042438)2.24886114
198L-fucose metabolic process (GO:0042354)2.24862888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.73511597
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.97329524
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.93035946
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45597534
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.40655269
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12959680
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95180981
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89180293
9MYC_22102868_ChIP-Seq_BL_Human2.82812240
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66864690
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59547213
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42031150
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40843656
14CIITA_25753668_ChIP-Seq_RAJI_Human2.32217698
15XRN2_22483619_ChIP-Seq_HELA_Human2.31052997
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27325217
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.23434567
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21672457
19LXR_22292898_ChIP-Seq_THP-1_Human2.19239630
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.14608117
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.08520940
22* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05950182
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05749856
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.02739160
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99045490
26VDR_21846776_ChIP-Seq_THP-1_Human1.95053311
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94992039
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94329372
29* GABP_17652178_ChIP-ChIP_JURKAT_Human1.91129750
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90588451
31* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88473664
32BCL6_27268052_Chip-Seq_Bcells_Human1.87415145
33P68_20966046_ChIP-Seq_HELA_Human1.85274138
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.81669745
35* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81485840
36* VDR_23849224_ChIP-Seq_CD4+_Human1.81446772
37KDM2B_26808549_Chip-Seq_DND41_Human1.78995499
38VDR_24763502_ChIP-Seq_THP-1_Human1.78271923
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.77777434
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77776769
41* DCP1A_22483619_ChIP-Seq_HELA_Human1.77434983
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77227330
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77030802
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76521265
45BCOR_27268052_Chip-Seq_Bcells_Human1.76347447
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75550389
47* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73607373
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68957922
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67791102
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.67148907
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67080913
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66701816
53RACK7_27058665_Chip-Seq_MCF-7_Human1.65562042
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65385818
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63352852
56* FOXP3_21729870_ChIP-Seq_TREG_Human1.62320130
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61711160
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60894434
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60179994
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60076222
61GABP_19822575_ChIP-Seq_HepG2_Human1.59569248
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.59126239
63TTF2_22483619_ChIP-Seq_HELA_Human1.57654456
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57326581
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55984087
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55568329
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54429423
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53818492
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.52461192
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51679452
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49470281
72* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44791891
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44449332
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43893212
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.43569998
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43249543
77KDM5A_27292631_Chip-Seq_BREAST_Human1.42603507
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42367554
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42034714
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41013977
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.40591103
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38008785
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37503816
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37415218
85E2F1_20622854_ChIP-Seq_HELA_Human1.37016098
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36227983
87PHF8_20622854_ChIP-Seq_HELA_Human1.36157033
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34158662
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34096540
90* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32355589
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31500526
92SMC4_20622854_ChIP-Seq_HELA_Human1.29997029
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29185874
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28304408
95AR_21909140_ChIP-Seq_LNCAP_Human1.27567992
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26654764
97YY1_22570637_ChIP-Seq_MALME-3M_Human1.25920619
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25075643
99NCOR1_26117541_ChIP-Seq_K562_Human1.25059085
100* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24870583
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23790868
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.23450782
103CTCF_26484167_Chip-Seq_Bcells_Mouse1.22840752
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22168940
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21778783
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21674824
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21448010
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19591757
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.19437270
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19311396
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19311396
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19311396
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17879029
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17876428
115* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17170111
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16631425
117MYB_26560356_Chip-Seq_TH1_Human1.15905512
118GATA1_19941827_ChIP-Seq_MEL_Mouse1.15580753
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14572233
120TP53_22127205_ChIP-Seq_IMR90_Human1.13821415
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13149215
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12514815
123FOXP1_21924763_ChIP-Seq_HESCs_Human1.12498845
124SPI1_23127762_ChIP-Seq_K562_Human1.11439800
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11189018
126ELK1_19687146_ChIP-ChIP_HELA_Human1.10894839
127PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10000312
128CREB1_26743006_Chip-Seq_LNCaP_Human1.09823647
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09477442
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09089299
131HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08995364
132NANOG_21062744_ChIP-ChIP_HESCs_Human1.08987511
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08442321
134RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08187904
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07860917
136TCF7_22412390_ChIP-Seq_EML_Mouse1.07171541
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06636007
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05465304
139ESR1_21235772_ChIP-Seq_MCF-7_Human1.05040771
140KDM2B_26808549_Chip-Seq_K562_Human1.04821636
141* ETS1_21867929_ChIP-Seq_TH2_Mouse1.04424353
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03955291
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03204578
144SA1_27219007_Chip-Seq_Bcells_Human1.02290517
145ATF3_27146783_Chip-Seq_COLON_Human1.02232626
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02126058
147ESR2_21235772_ChIP-Seq_MCF-7_Human1.01788387
148CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01319424
149UTX_26944678_Chip-Seq_JUKART_Human0.99953386
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99533251
151ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98170821
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97868536
153* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97526479
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97355652
155MYC_18940864_ChIP-ChIP_HL60_Human0.96775412
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94743664
157PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94382672
158MAF_26560356_Chip-Seq_TH2_Human0.93872283
159TFEB_21752829_ChIP-Seq_HELA_Human0.92724886
160MAF_26560356_Chip-Seq_TH1_Human0.92694475
161TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91267910
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89225494
163TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88993170
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86643788
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86469381
166SPI1_23547873_ChIP-Seq_NB4_Human0.83390324
167SCL_19346495_ChIP-Seq_HPC-7_Human0.82979398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.44318923
2MP0003111_abnormal_nucleus_morphology3.94468323
3MP0008057_abnormal_DNA_replication3.91957906
4MP0010094_abnormal_chromosome_stability3.71890250
5MP0008058_abnormal_DNA_repair3.50679069
6MP0002396_abnormal_hematopoietic_system3.46434144
7MP0005451_abnormal_body_composition3.32054086
8MP0003077_abnormal_cell_cycle3.29336379
9MP0004957_abnormal_blastocyst_morpholog3.28905591
10MP0005058_abnormal_lysosome_morphology3.19407879
11MP0003172_abnormal_lysosome_physiology3.16915916
12MP0005076_abnormal_cell_differentiation3.13404703
13MP0003436_decreased_susceptibility_to3.07763189
14MP0009840_abnormal_foam_cell2.93317853
15MP0002132_abnormal_respiratory_system2.66144223
16MP0000350_abnormal_cell_proliferation2.62263928
17MP0003786_premature_aging2.48707581
18MP0010307_abnormal_tumor_latency2.45857724
19MP0008260_abnormal_autophagy2.36644179
20MP0006082_CNS_inflammation2.30600334
21MP0001730_embryonic_growth_arrest2.18308832
22MP0000372_irregular_coat_pigmentation2.13559745
23MP0008932_abnormal_embryonic_tissue2.10980245
24MP0008007_abnormal_cellular_replicative2.10848103
25MP0000015_abnormal_ear_pigmentation2.06511914
26MP0001873_stomach_inflammation2.02559413
27MP0004808_abnormal_hematopoietic_stem2.02311754
28MP0005025_abnormal_response_to2.00868358
29MP0010352_gastrointestinal_tract_polyps1.93787053
30MP0002419_abnormal_innate_immunity1.89010127
31MP0001800_abnormal_humoral_immune1.81853687
32MP0003890_abnormal_embryonic-extraembry1.81423736
33MP0010030_abnormal_orbit_morphology1.80442486
34MP0000490_abnormal_crypts_of1.76354247
35MP0002653_abnormal_ependyma_morphology1.75679350
36MP0005000_abnormal_immune_tolerance1.75314963
37MP0005310_abnormal_salivary_gland1.74004392
38MP0003646_muscle_fatigue1.73975039
39MP0002723_abnormal_immune_serum1.73323259
40MP0000537_abnormal_urethra_morphology1.72585837
41MP0005671_abnormal_response_to1.72168815
42MP0002084_abnormal_developmental_patter1.71393233
43MP0009785_altered_susceptibility_to1.69896807
44MP0003763_abnormal_thymus_physiology1.69698061
45MP0004133_heterotaxia1.68568734
46MP0005083_abnormal_biliary_tract1.68320831
47MP0002085_abnormal_embryonic_tissue1.66220361
48MP0000703_abnormal_thymus_morphology1.66020039
49MP0002452_abnormal_antigen_presenting1.64190167
50MP0004197_abnormal_fetal_growth/weight/1.62600914
51MP0005387_immune_system_phenotype1.62222630
52MP0001790_abnormal_immune_system1.62222630
53MP0005380_embryogenesis_phenotype1.61636039
54MP0001672_abnormal_embryogenesis/_devel1.61636039
55MP0000678_abnormal_parathyroid_gland1.58968037
56MP0003315_abnormal_perineum_morphology1.57909092
57MP0001697_abnormal_embryo_size1.57792831
58MP0001819_abnormal_immune_cell1.56439988
59MP0003984_embryonic_growth_retardation1.56087132
60MP0002420_abnormal_adaptive_immunity1.55676412
61MP0000685_abnormal_immune_system1.54128323
62MP0001764_abnormal_homeostasis1.54100372
63MP0002088_abnormal_embryonic_growth/wei1.52309831
64MP0002080_prenatal_lethality1.51429034
65MP0002254_reproductive_system_inflammat1.50688342
66MP0009278_abnormal_bone_marrow1.47514921
67MP0000313_abnormal_cell_death1.46651488
68MP0009333_abnormal_splenocyte_physiolog1.45220134
69MP0005023_abnormal_wound_healing1.44658412
70MP0001545_abnormal_hematopoietic_system1.43258650
71MP0005397_hematopoietic_system_phenotyp1.43258650
72MP0002148_abnormal_hypersensitivity_rea1.42725942
73MP0000428_abnormal_craniofacial_morphol1.41412820
74MP0003303_peritoneal_inflammation1.40069711
75MP0001293_anophthalmia1.38763066
76MP0009764_decreased_sensitivity_to1.38571918
77MP0003656_abnormal_erythrocyte_physiolo1.36526582
78MP0001845_abnormal_inflammatory_respons1.33636364
79MP0002019_abnormal_tumor_incidence1.32198399
80MP0003191_abnormal_cellular_cholesterol1.31996820
81MP0003942_abnormal_urinary_system1.31562332
82MP0005408_hypopigmentation1.28244815
83MP0002111_abnormal_tail_morphology1.27852394
84MP0004381_abnormal_hair_follicle1.26759583
85MP0002398_abnormal_bone_marrow1.24880639
86MP0001835_abnormal_antigen_presentation1.24567282
87MP0002086_abnormal_extraembryonic_tissu1.22742879
88MP0000681_abnormal_thyroid_gland1.21432632
89MP0002722_abnormal_immune_system1.20950090
90MP0004858_abnormal_nervous_system1.20195402
91MP0001727_abnormal_embryo_implantation1.18158232
92* MP0008469_abnormal_protein_level1.17619820
93MP0003123_paternal_imprinting1.17348758
94MP0006036_abnormal_mitochondrial_physio1.16580568
95MP0002092_abnormal_eye_morphology1.16246711
96MP0000689_abnormal_spleen_morphology1.16159678
97MP0004947_skin_inflammation1.16014190
98MP0002138_abnormal_hepatobiliary_system1.13664650
99MP0005646_abnormal_pituitary_gland1.12314131
100MP0002751_abnormal_autonomic_nervous1.10005229
101MP0002249_abnormal_larynx_morphology1.09208113
102MP0008877_abnormal_DNA_methylation1.08284650
103MP0010155_abnormal_intestine_physiology1.07620624
104MP0003195_calcinosis1.06128382
105MP0005621_abnormal_cell_physiology1.05872496
106MP0000049_abnormal_middle_ear1.05726076
107MP0005464_abnormal_platelet_physiology1.04067984
108MP0003119_abnormal_digestive_system1.03905650
109MP0003937_abnormal_limbs/digits/tail_de1.03889824
110MP0005384_cellular_phenotype1.02662125
111MP0001533_abnormal_skeleton_physiology1.01595432
112MP0003121_genomic_imprinting0.97256210
113MP0004233_abnormal_muscle_weight0.96834475
114MP0003075_altered_response_to0.96528602
115MP0000358_abnormal_cell_content/0.96486718
116MP0003943_abnormal_hepatobiliary_system0.96417065
117MP0005394_taste/olfaction_phenotype0.95339605
118MP0005499_abnormal_olfactory_system0.95339605
119MP0003861_abnormal_nervous_system0.93769370
120MP0005167_abnormal_blood-brain_barrier0.92372125
121MP0003866_abnormal_defecation0.91759593
122MP0000858_altered_metastatic_potential0.90072823
123MP0002075_abnormal_coat/hair_pigmentati0.89870887
124MP0004185_abnormal_adipocyte_glucose0.86553740
125MP0003283_abnormal_digestive_organ0.86532261
126MP0000371_diluted_coat_color0.85906227
127MP0002210_abnormal_sex_determination0.84995138
128MP0004510_myositis0.84553374
129MP0002429_abnormal_blood_cell0.84312112
130MP0002877_abnormal_melanocyte_morpholog0.83655712
131MP0005410_abnormal_fertilization0.82905070
132MP0002332_abnormal_exercise_endurance0.82562595
133MP0008995_early_reproductive_senescence0.82519332
134MP0005647_abnormal_sex_gland0.82408681
135MP0001661_extended_life_span0.80674315
136MP0000604_amyloidosis0.80006317
137MP0003724_increased_susceptibility_to0.79703084
138MP0003115_abnormal_respiratory_system0.77968711
139MP0008770_decreased_survivor_rate0.77875018
140MP0002932_abnormal_joint_morphology0.77547743
141MP0001915_intracranial_hemorrhage0.77185940
142MP0000432_abnormal_head_morphology0.77067208
143MP0001186_pigmentation_phenotype0.76649201
144MP0008789_abnormal_olfactory_epithelium0.76120199
145MP0000516_abnormal_urinary_system0.75847874
146MP0005367_renal/urinary_system_phenotyp0.75847874
147MP0003091_abnormal_cell_migration0.74996546
148MP0005075_abnormal_melanosome_morpholog0.74508540
149MP0009703_decreased_birth_body0.74254487
150MP0006035_abnormal_mitochondrial_morpho0.74206659
151MP0000609_abnormal_liver_physiology0.74050172
152MP0002693_abnormal_pancreas_physiology0.73300543
153MP0000465_gastrointestinal_hemorrhage0.73149771
154MP0000716_abnormal_immune_system0.72792867
155MP0002089_abnormal_postnatal_growth/wei0.72771337
156MP0003935_abnormal_craniofacial_develop0.72171703
157MP0003566_abnormal_cell_adhesion0.71053294
158MP0003183_abnormal_peptide_metabolism0.71017087
159MP0003567_abnormal_fetal_cardiomyocyte0.70862062
160MP0000477_abnormal_intestine_morphology0.69816783
161MP0001919_abnormal_reproductive_system0.68537283
162MP0002116_abnormal_craniofacial_bone0.67915435
163MP0002405_respiratory_system_inflammati0.67873066
164MP0008961_abnormal_basal_metabolism0.67289592
165MP0003705_abnormal_hypodermis_morpholog0.67184213
166MP0002697_abnormal_eye_size0.67179140
167MP0003300_gastrointestinal_ulcer0.66476475
168MP0003755_abnormal_palate_morphology0.66301411
169MP0002114_abnormal_axial_skeleton0.64986614
170MP0001929_abnormal_gametogenesis0.64833760
171MP0005389_reproductive_system_phenotype0.63571470
172MP0005220_abnormal_exocrine_pancreas0.62543021
173MP0000534_abnormal_ureter_morphology0.62448685

Predicted human phenotypes

RankGene SetZ-score
1Carpal bone hypoplasia (HP:0001498)4.85012910
2Aplasia/Hypoplasia of the uvula (HP:0010293)4.09967650
3Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.95807386
4* Stridor (HP:0010307)3.92693282
5Abnormality of the labia minora (HP:0012880)3.49928580
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46258401
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.43830244
8Patellar aplasia (HP:0006443)3.42070657
9Abnormality of chromosome stability (HP:0003220)3.37780144
10Abnormality of glycolipid metabolism (HP:0010969)3.37722452
11Abnormality of liposaccharide metabolism (HP:0010968)3.37722452
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.37722452
13Mediastinal lymphadenopathy (HP:0100721)3.34940579
14Increased cerebral lipofuscin (HP:0011813)3.32707162
15Abnormal number of incisors (HP:0011064)3.31171401
16Loss of speech (HP:0002371)3.22499195
17Chromsome breakage (HP:0040012)3.21640649
18Ependymoma (HP:0002888)3.20771998
19Aplasia/Hypoplasia of the patella (HP:0006498)3.14520629
20Ragged-red muscle fibers (HP:0003200)3.10274691
21Meckel diverticulum (HP:0002245)3.08201772
22Upper limb amyotrophy (HP:0009129)3.04591830
23Distal upper limb amyotrophy (HP:0007149)3.04591830
24Microretrognathia (HP:0000308)3.02889448
25Selective tooth agenesis (HP:0001592)3.02106882
26Gonadal dysgenesis (HP:0000133)3.00535226
27Abnormality of cells of the erythroid lineage (HP:0012130)2.99407912
28Birth length less than 3rd percentile (HP:0003561)2.96483340
29Abnormality of the ileum (HP:0001549)2.96267302
30Abnormality of the preputium (HP:0100587)2.93274906
31Anomalous pulmonary venous return (HP:0010772)2.92976653
32Hand muscle atrophy (HP:0009130)2.92645323
33Abnormality of lateral ventricle (HP:0030047)2.92119723
34Small epiphyses (HP:0010585)2.91608916
35Abnormal number of erythroid precursors (HP:0012131)2.88563863
36Petechiae (HP:0000967)2.88054606
37Albinism (HP:0001022)2.85371121
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.84694401
39Mesangial abnormality (HP:0001966)2.84303439
40Tetany (HP:0001281)2.83936284
41Testicular neoplasm (HP:0010788)2.79724218
42Dry hair (HP:0011359)2.77739401
43Reticulocytopenia (HP:0001896)2.75856232
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75754254
45Recurrent bacterial skin infections (HP:0005406)2.75435599
46Recurrent abscess formation (HP:0002722)2.71069684
47Abnormality of the astrocytes (HP:0100707)2.70530205
48Astrocytoma (HP:0009592)2.70530205
49Absent radius (HP:0003974)2.70342153
50Absent thumb (HP:0009777)2.69825681
51Pustule (HP:0200039)2.67042087
52Progressive muscle weakness (HP:0003323)2.62921379
53Abnormality of T cell physiology (HP:0011840)2.62685148
54Optic nerve coloboma (HP:0000588)2.61571731
55Recurrent fungal infections (HP:0002841)2.60857819
56Anal stenosis (HP:0002025)2.56301381
57J-shaped sella turcica (HP:0002680)2.55173920
58Dysostosis multiplex (HP:0000943)2.53602968
59Abnormality of the pulmonary veins (HP:0011718)2.52956639
60Absent forearm bone (HP:0003953)2.52270048
61Aplasia involving forearm bones (HP:0009822)2.52270048
62* Diaphragmatic weakness (HP:0009113)2.50465628
63Ocular albinism (HP:0001107)2.50252154
64Myelodysplasia (HP:0002863)2.50114220
65Delayed CNS myelination (HP:0002188)2.49299429
66Colon cancer (HP:0003003)2.49243731
67Eczematoid dermatitis (HP:0000976)2.48614783
68Glioma (HP:0009733)2.47182649
69Abnormality of macrophages (HP:0004311)2.46946005
70Severe visual impairment (HP:0001141)2.40197888
71Clumsiness (HP:0002312)2.39788073
72Stomatitis (HP:0010280)2.39703013
73Clubbing of toes (HP:0100760)2.39647900
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38884356
75Abnormality of alanine metabolism (HP:0010916)2.38884356
76Hyperalaninemia (HP:0003348)2.38884356
77Medulloblastoma (HP:0002885)2.35476755
78Triphalangeal thumb (HP:0001199)2.32835186
79Cafe-au-lait spot (HP:0000957)2.32765644
80Myopathic facies (HP:0002058)2.31360314
81Duodenal stenosis (HP:0100867)2.29856299
82Small intestinal stenosis (HP:0012848)2.29856299
83Elevated erythrocyte sedimentation rate (HP:0003565)2.29662374
84Abnormality of pyrimidine metabolism (HP:0004353)2.29119758
8511 pairs of ribs (HP:0000878)2.28949371
86Basal cell carcinoma (HP:0002671)2.27963504
87Abnormality of DNA repair (HP:0003254)2.27662105
88Recurrent cutaneous fungal infections (HP:0011370)2.27605984
89Chronic mucocutaneous candidiasis (HP:0002728)2.27605984
90Abnormality of the fingertips (HP:0001211)2.23660567
91Preauricular skin tag (HP:0000384)2.23341932
92Rhabdomyosarcoma (HP:0002859)2.21472732
93Vacuolated lymphocytes (HP:0001922)2.18093567
94Progressive microcephaly (HP:0000253)2.17804888
95Short 4th metacarpal (HP:0010044)2.17535122
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17535122
97Abnormality of polysaccharide metabolism (HP:0011012)2.15939071
98Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15939071
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15939071
100Testicular atrophy (HP:0000029)2.14583215
101High pitched voice (HP:0001620)2.13999088
102Increased serum ferritin (HP:0003281)2.13417907
103Myositis (HP:0100614)2.12953321
104Skin tags (HP:0010609)2.11413874
105Rough bone trabeculation (HP:0100670)2.10437578
106Ectopic kidney (HP:0000086)2.09739995
107Pallor (HP:0000980)2.09683918
108Missing ribs (HP:0000921)2.09405982
109Choanal atresia (HP:0000453)2.09148966
110Biliary tract neoplasm (HP:0100574)2.08000068
111Tongue fasciculations (HP:0001308)2.07122595
112Wrist flexion contracture (HP:0001239)2.06670432
113Glossoptosis (HP:0000162)2.06441886
114Horseshoe kidney (HP:0000085)2.05061027
115Impaired proprioception (HP:0010831)2.03475471
116Bulbar palsy (HP:0001283)2.03392642
117Aplasia/Hypoplasia of the sternum (HP:0006714)2.02936265
118Abnormality of the duodenum (HP:0002246)2.02528899
119Neoplasm of the pancreas (HP:0002894)2.02457459
120Bone marrow hypocellularity (HP:0005528)2.01805256
121Glomerulosclerosis (HP:0000096)2.00851485
122Muscle fibrillation (HP:0010546)2.00254318
123Iris hypopigmentation (HP:0007730)2.00164227
124Poikiloderma (HP:0001029)1.99967800
125Focal segmental glomerulosclerosis (HP:0000097)1.99395321
126Aplastic anemia (HP:0001915)1.99140058
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97928465
128Pelvic girdle muscle weakness (HP:0003749)1.97687481
129Cheilitis (HP:0100825)1.97472385
130Cholecystitis (HP:0001082)1.95977886
131Abnormal gallbladder physiology (HP:0012438)1.95977886
132Aplasia/hypoplasia of the humerus (HP:0006507)1.95380022
133Abnormality of the carotid arteries (HP:0005344)1.95025448
134Abnormality of oral frenula (HP:0000190)1.92663398
135Septo-optic dysplasia (HP:0100842)1.91375204
136Chronic obstructive pulmonary disease (HP:0006510)1.90879277
137Obstructive lung disease (HP:0006536)1.90879277
138Prominent nose (HP:0000448)1.90734794
139Urethral obstruction (HP:0000796)1.90133507
140Recurrent skin infections (HP:0001581)1.89596810
141Shoulder girdle muscle weakness (HP:0003547)1.88219384
142Long palpebral fissure (HP:0000637)1.87864748
143Prolonged neonatal jaundice (HP:0006579)1.87655115
144Nasal polyposis (HP:0100582)1.87278735
145Flattened epiphyses (HP:0003071)1.87217792
146Abnormality of the vocal cords (HP:0008777)1.86857839
147Urinary glycosaminoglycan excretion (HP:0003541)1.84698367
148Mucopolysacchariduria (HP:0008155)1.84698367
149Disproportionate short-trunk short stature (HP:0003521)1.84533766
150Tracheoesophageal fistula (HP:0002575)1.84149871
151Amyotrophic lateral sclerosis (HP:0007354)1.83341730
152Long eyelashes (HP:0000527)1.83204183
153Panhypogammaglobulinemia (HP:0003139)1.83040539
154Systemic lupus erythematosus (HP:0002725)1.82837701
155Hypochromic anemia (HP:0001931)1.82694268
156Recurrent gram-negative bacterial infections (HP:0005420)1.82568950
157Cellular immunodeficiency (HP:0005374)1.82037555
158Thoracic kyphosis (HP:0002942)1.81148325
159Spinal cord lesions (HP:0100561)1.80239475
160Syringomyelia (HP:0003396)1.80239475
161Impulsivity (HP:0100710)1.78832553
162Ankle clonus (HP:0011448)1.78307348
163Reticulocytosis (HP:0001923)1.78225190
164Hypoplastic pelvis (HP:0008839)1.78193816
165Easy fatigability (HP:0003388)1.76214419
166Hyperthyroidism (HP:0000836)1.75726235
167Short humerus (HP:0005792)1.75690453
168Abnormal pancreas size (HP:0012094)1.75668464
169Abnormality of the vertebral endplates (HP:0005106)1.74029002
170Autoimmune thrombocytopenia (HP:0001973)1.73940729
171Hypoplastic iliac wings (HP:0002866)1.73847284
172Short thumb (HP:0009778)1.73462550
173Hypokinesia (HP:0002375)1.73128746
174Shallow orbits (HP:0000586)1.72962964
175Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71532481
176Opisthotonus (HP:0002179)1.71419782
177Abnormality of the hip-girdle musculature (HP:0001445)1.71036463
178Abnormality of the musculature of the pelvis (HP:0001469)1.71036463
179Maternal diabetes (HP:0009800)1.70318291
180Transposition of the great arteries (HP:0001669)1.69957341
181Abnormal connection of the cardiac segments (HP:0011545)1.69957341
182Abnormal ventriculo-arterial connection (HP:0011563)1.69957341
183Ankyloglossia (HP:0010296)1.69838933
184Obstructive sleep apnea (HP:0002870)1.68624936
185Neoplasm of striated muscle (HP:0009728)1.68178400
186Synostosis of carpal bones (HP:0005048)1.65954902
187Abnormality of the incisor (HP:0000676)1.65725117
188Sloping forehead (HP:0000340)1.65620909
189Arteriovenous malformation (HP:0100026)1.64570857
190Joint stiffness (HP:0001387)1.64293933
191Bicuspid aortic valve (HP:0001647)1.64270278
192T lymphocytopenia (HP:0005403)1.63684901
193Pendular nystagmus (HP:0012043)1.63387802
194Barrel-shaped chest (HP:0001552)1.63247433
195Interstitial pulmonary disease (HP:0006530)1.61917126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.22033516
2ACVR1B3.92556956
3EIF2AK33.71574002
4EEF2K3.38921640
5KSR13.33342861
6IRAK33.18369049
7BUB13.12296382
8CDC72.76713083
9TNK22.41510962
10NTRK12.37236544
11WEE12.36334698
12MAP3K102.32668775
13SMG12.26938642
14TYK22.22479385
15IRAK42.12685349
16PRPF4B2.06399002
17TBK12.02382091
18RPS6KB21.95826819
19MARK31.87752736
20TLK11.75364605
21TGFBR11.71141733
22NTRK21.70021515
23PASK1.63885896
24PRKD21.63582902
25MARK21.61093719
26NEK21.60618514
27TAOK11.59527868
28MAPKAPK31.59120998
29TTK1.56006103
30PRKD31.55798194
31EPHB21.55539595
32MAP3K31.52828282
33EIF2AK11.50987625
34CDK121.50897880
35MAP3K141.46690172
36SIK11.45345760
37MAP2K31.44961569
38TSSK61.43852033
39PLK11.42196145
40STK101.32789440
41ZAP701.31301027
42PTK61.29424421
43SRPK11.29189269
44MAP3K71.28918451
45MAP4K11.26156767
46PAK41.23266056
47CDK41.22900567
48EPHA21.20507086
49STK161.20258204
50IKBKE1.17572894
51CDK71.13951720
52CCNB11.13683114
53ATR1.13134039
54FES1.10601313
55PRKCI1.10139593
56RIPK41.08253548
57AURKB1.06600036
58GRK61.06415920
59ITK1.06201773
60ALK1.04290158
61TESK21.03026655
62NME11.01836766
63MAP3K81.01732756
64ICK1.01214268
65BCR1.00513700
66CAMK1D0.98909491
67NME20.96486632
68CHEK20.95647438
69CHUK0.94888547
70BLK0.94247271
71MUSK0.93963511
72MAP3K110.93422548
73MTOR0.92240237
74IRAK10.88750841
75PKN20.87889414
76STK40.87415919
77MELK0.86232266
78TRIB30.84127738
79ERN10.83990981
80RPS6KC10.83844857
81RPS6KL10.83844857
82SIK20.83203462
83TAOK30.80425467
84CHEK10.79986491
85CDK20.79352417
86RPS6KA60.78219956
87PTK2B0.78202910
88MAP2K60.78048256
89EPHB10.77894746
90PDPK10.74302409
91RPS6KA20.73660395
92MAP3K10.73038594
93AURKA0.71418777
94TESK10.71292183
95BRSK20.71281769
96PDK20.71105270
97NEK10.69628951
98JAK30.69358739
99BCKDK0.69322991
100DAPK20.68440555
101HCK0.67568462
102PRKAA10.67262224
103ERBB20.67106794
104PIM10.66729913
105IRAK20.65920086
106TAOK20.64881307
107GSK3A0.63970753
108CDC42BPA0.63871177
109HIPK20.61680730
110PRKAA20.61263633
111KDR0.59966462
112CDK60.59950612
113RIPK10.59846110
114FRK0.59255015
115PDK10.58538337
116RAF10.57950856
117DAPK10.57682428
118VRK20.57287310
119LRRK20.56302827
120PIM20.56142043
121BTK0.55995279
122BRAF0.55867339
123MAP3K90.55540563
124CDK10.54685221
125MAP3K130.54105289
126BRSK10.53354304
127CDK90.53228102
128SCYL20.53034083
129ATM0.51767880
130DYRK30.51744018
131LATS20.50030392
132BRD40.48946620
133STK380.48892391
134WNK40.48513277
135PLK30.48448704
136PRKG20.48053843
137MKNK20.46544679
138CSNK1G30.46503440
139PRKCZ0.45670552
140MKNK10.45283826
141VRK10.44366138
142LMTK20.43279448
143FGFR30.42020954
144PAK10.41906714
145LYN0.40716658
146CSF1R0.40675175
147RPS6KA10.40377809
148AKT30.40060076
149ARAF0.39335492
150PAK20.36944134
151TTN0.35571172
152CSNK2A20.34134604
153CSNK1E0.32452135
154DYRK20.32128713
155MARK10.31674764
156AKT20.31114214
157MAPK90.30970932
158MAPK80.29617196
159MATK0.28910377
160RPS6KA40.25301440
161IKBKB0.24292905
162MAPKAPK20.24161918
163MAPK10.23796539
164DYRK1B0.23433544
165FGFR10.23046165

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.42837424
2Other glycan degradation_Homo sapiens_hsa005113.94670521
3Mismatch repair_Homo sapiens_hsa034303.59414041
4Spliceosome_Homo sapiens_hsa030403.32496717
5Base excision repair_Homo sapiens_hsa034103.20236512
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19343415
7RNA transport_Homo sapiens_hsa030132.79113385
8Ribosome_Homo sapiens_hsa030102.72935463
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70895534
10One carbon pool by folate_Homo sapiens_hsa006702.58712099
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.57688792
12Cell cycle_Homo sapiens_hsa041102.47744223
13RNA polymerase_Homo sapiens_hsa030202.47071848
14Nucleotide excision repair_Homo sapiens_hsa034202.33676548
15Pyrimidine metabolism_Homo sapiens_hsa002402.28833175
16Osteoclast differentiation_Homo sapiens_hsa043802.14212947
17Homologous recombination_Homo sapiens_hsa034402.06074234
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02171909
19Lysosome_Homo sapiens_hsa041421.97150743
20mRNA surveillance pathway_Homo sapiens_hsa030151.91833072
21Proteasome_Homo sapiens_hsa030501.86088416
22Fanconi anemia pathway_Homo sapiens_hsa034601.81465297
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76693507
24Leishmaniasis_Homo sapiens_hsa051401.60390210
25TNF signaling pathway_Homo sapiens_hsa046681.59940624
26Tuberculosis_Homo sapiens_hsa051521.53253253
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51485272
28Chronic myeloid leukemia_Homo sapiens_hsa052201.49063810
29Graft-versus-host disease_Homo sapiens_hsa053321.48411341
30RNA degradation_Homo sapiens_hsa030181.47055880
31Hepatitis C_Homo sapiens_hsa051601.45169504
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42479757
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41749001
34Epstein-Barr virus infection_Homo sapiens_hsa051691.40274799
35p53 signaling pathway_Homo sapiens_hsa041151.39858859
36Bladder cancer_Homo sapiens_hsa052191.38011041
37Staphylococcus aureus infection_Homo sapiens_hsa051501.33730287
38Notch signaling pathway_Homo sapiens_hsa043301.29809230
39Vitamin B6 metabolism_Homo sapiens_hsa007501.26952436
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26724613
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24413175
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.22219069
43HTLV-I infection_Homo sapiens_hsa051661.20061411
44Viral carcinogenesis_Homo sapiens_hsa052031.16993139
45Selenocompound metabolism_Homo sapiens_hsa004501.16042266
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.15615779
47Colorectal cancer_Homo sapiens_hsa052101.15091578
48Allograft rejection_Homo sapiens_hsa053301.08081511
49Herpes simplex infection_Homo sapiens_hsa051681.07400888
50MicroRNAs in cancer_Homo sapiens_hsa052061.03866572
51Basal transcription factors_Homo sapiens_hsa030221.03783778
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03722798
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03352076
54Purine metabolism_Homo sapiens_hsa002301.03241676
55Systemic lupus erythematosus_Homo sapiens_hsa053221.02106398
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.01913821
57Non-homologous end-joining_Homo sapiens_hsa034501.01384363
58Oocyte meiosis_Homo sapiens_hsa041140.99792091
59Collecting duct acid secretion_Homo sapiens_hsa049660.97072228
60Toxoplasmosis_Homo sapiens_hsa051450.96625998
61Non-small cell lung cancer_Homo sapiens_hsa052230.94892374
62Primary immunodeficiency_Homo sapiens_hsa053400.93286851
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.92977195
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92526805
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91646910
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88614797
67N-Glycan biosynthesis_Homo sapiens_hsa005100.88058913
68African trypanosomiasis_Homo sapiens_hsa051430.87582942
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87276173
70Hepatitis B_Homo sapiens_hsa051610.86814247
71Basal cell carcinoma_Homo sapiens_hsa052170.85970200
72Hippo signaling pathway_Homo sapiens_hsa043900.85569441
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83479890
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82195116
75Rheumatoid arthritis_Homo sapiens_hsa053230.81322151
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81320423
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79867013
78Insulin resistance_Homo sapiens_hsa049310.79713523
79T cell receptor signaling pathway_Homo sapiens_hsa046600.78567194
80Thyroid cancer_Homo sapiens_hsa052160.78514982
81Shigellosis_Homo sapiens_hsa051310.77715639
82Apoptosis_Homo sapiens_hsa042100.77469378
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76955868
84Measles_Homo sapiens_hsa051620.76698577
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.76599384
86Folate biosynthesis_Homo sapiens_hsa007900.76380696
87Acute myeloid leukemia_Homo sapiens_hsa052210.76356551
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75463344
89Autoimmune thyroid disease_Homo sapiens_hsa053200.73711435
90Endometrial cancer_Homo sapiens_hsa052130.73439628
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.73267413
92Pancreatic cancer_Homo sapiens_hsa052120.72944489
93Antigen processing and presentation_Homo sapiens_hsa046120.72130061
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72079147
95Synaptic vesicle cycle_Homo sapiens_hsa047210.71957324
96Sphingolipid metabolism_Homo sapiens_hsa006000.70600381
97B cell receptor signaling pathway_Homo sapiens_hsa046620.69808254
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.69713629
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69247025
100Prolactin signaling pathway_Homo sapiens_hsa049170.68844929
101Small cell lung cancer_Homo sapiens_hsa052220.67626356
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.65772298
103Biosynthesis of amino acids_Homo sapiens_hsa012300.62872389
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.61473627
105ErbB signaling pathway_Homo sapiens_hsa040120.59809282
106Pentose phosphate pathway_Homo sapiens_hsa000300.58977169
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58685721
108Pertussis_Homo sapiens_hsa051330.58044663
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57998033
110Legionellosis_Homo sapiens_hsa051340.57499486
111mTOR signaling pathway_Homo sapiens_hsa041500.56991698
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.56770165
113TGF-beta signaling pathway_Homo sapiens_hsa043500.56349737
114Sulfur relay system_Homo sapiens_hsa041220.54807615
115Viral myocarditis_Homo sapiens_hsa054160.54420963
116Lysine degradation_Homo sapiens_hsa003100.54318566
117Hedgehog signaling pathway_Homo sapiens_hsa043400.53010518
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52375488
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50417999
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.49992650
121Phagosome_Homo sapiens_hsa041450.49482181
122Salmonella infection_Homo sapiens_hsa051320.48660704
123Alcoholism_Homo sapiens_hsa050340.48084815
124Glioma_Homo sapiens_hsa052140.47328528
125Type I diabetes mellitus_Homo sapiens_hsa049400.47076644
126Pathways in cancer_Homo sapiens_hsa052000.46181543
127Regulation of autophagy_Homo sapiens_hsa041400.46037940
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45516479
129Influenza A_Homo sapiens_hsa051640.44785882
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44171392
131Adherens junction_Homo sapiens_hsa045200.43081558
132Prostate cancer_Homo sapiens_hsa052150.42876225
133Malaria_Homo sapiens_hsa051440.42535699
134Endocytosis_Homo sapiens_hsa041440.42268841
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41687837
136Choline metabolism in cancer_Homo sapiens_hsa052310.41042127
137Wnt signaling pathway_Homo sapiens_hsa043100.40601835
138VEGF signaling pathway_Homo sapiens_hsa043700.39444941
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.39013688
140Chemokine signaling pathway_Homo sapiens_hsa040620.38361031
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37952619
142Type II diabetes mellitus_Homo sapiens_hsa049300.37690373
143AMPK signaling pathway_Homo sapiens_hsa041520.37219929
144Fatty acid elongation_Homo sapiens_hsa000620.36929260
145Proteoglycans in cancer_Homo sapiens_hsa052050.36807415
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36353497
147Hematopoietic cell lineage_Homo sapiens_hsa046400.34897791
148FoxO signaling pathway_Homo sapiens_hsa040680.34701939
149Fructose and mannose metabolism_Homo sapiens_hsa000510.34545467
150HIF-1 signaling pathway_Homo sapiens_hsa040660.32861521
151Insulin signaling pathway_Homo sapiens_hsa049100.30536097
152Renal cell carcinoma_Homo sapiens_hsa052110.30047190

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