IGHV1-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell proliferation (GO:0030889)9.53152450
2B cell receptor signaling pathway (GO:0050853)8.03601788
3positive regulation of respiratory burst (GO:0060267)7.96853524
4gonadal mesoderm development (GO:0007506)7.86402333
5complement activation, classical pathway (GO:0006958)7.52261598
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.10715669
7glomerular filtration (GO:0003094)7.06916418
8regulation of regulatory T cell differentiation (GO:0045589)6.86928728
9antigen processing and presentation of endogenous antigen (GO:0019883)6.58092895
10renal filtration (GO:0097205)6.36573945
11regulation of B cell proliferation (GO:0030888)5.99190044
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.87588260
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.87588260
14positive regulation of gamma-delta T cell activation (GO:0046645)5.82283070
15complement activation (GO:0006956)5.79334380
16positive regulation of B cell differentiation (GO:0045579)5.67009423
17regulation of respiratory burst (GO:0060263)5.35293420
18regulation of B cell differentiation (GO:0045577)5.32555145
19B cell proliferation (GO:0042100)5.29796472
20regulation of B cell receptor signaling pathway (GO:0050855)5.06867526
21negative regulation of B cell activation (GO:0050869)5.00422464
22regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.80968860
23antibacterial humoral response (GO:0019731)4.67950738
24antimicrobial humoral response (GO:0019730)4.66161928
25immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.66051537
26Fc-gamma receptor signaling pathway (GO:0038094)4.66051537
27Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.66051537
28regulation of MHC class II biosynthetic process (GO:0045346)4.64410426
29Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.63031957
30negative regulation of cell aging (GO:0090344)4.59456539
31regulation of chronic inflammatory response (GO:0002676)4.55595259
32defense response to protozoan (GO:0042832)4.53916871
33regulation of gamma-delta T cell differentiation (GO:0045586)4.50259443
34negative regulation of glucose import (GO:0046325)4.36227955
35CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.27942628
36regulation of B cell activation (GO:0050864)4.21888047
37immune response-activating cell surface receptor signaling pathway (GO:0002429)4.16892632
38humoral immune response (GO:0006959)4.16812675
39serine transport (GO:0032329)4.11705724
40regulation of cytokine secretion involved in immune response (GO:0002739)4.11424645
41cellular response to zinc ion (GO:0071294)4.06947345
42L-serine transport (GO:0015825)4.05881814
43negative regulation of cell killing (GO:0031342)4.04599179
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04599179
45retina homeostasis (GO:0001895)4.03272226
46leukocyte aggregation (GO:0070486)4.03115326
47regulation of cellular extravasation (GO:0002691)4.02302078
48immunoglobulin mediated immune response (GO:0016064)4.00738321
49response to protozoan (GO:0001562)3.98427787
50regulation of gamma-delta T cell activation (GO:0046643)3.94800993
51antigen receptor-mediated signaling pathway (GO:0050851)3.88631454
52regulation of B cell apoptotic process (GO:0002902)3.87855547
53positive regulation of immunoglobulin production (GO:0002639)3.87304939
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.85567964
55negative regulation of nitric oxide biosynthetic process (GO:0045019)3.77248186
56regulation of immunoglobulin production (GO:0002637)3.73982049
57regulation of alpha-beta T cell proliferation (GO:0046640)3.72039787
58mature B cell differentiation (GO:0002335)3.67337765
59protein activation cascade (GO:0072376)3.64221072
60T cell lineage commitment (GO:0002360)3.63899477
61hepatocyte apoptotic process (GO:0097284)3.60966201
62negative regulation of humoral immune response (GO:0002921)3.60252805
63type I interferon signaling pathway (GO:0060337)3.57731532
64cellular response to type I interferon (GO:0071357)3.57731532
65germinal center formation (GO:0002467)3.57442913
66positive thymic T cell selection (GO:0045059)3.56765783
67detection of bacterium (GO:0016045)3.55922671
68negative regulation of glucose transport (GO:0010829)3.55868286
69signal peptide processing (GO:0006465)3.55165420
70detection of other organism (GO:0098543)3.54603906
71response to type I interferon (GO:0034340)3.54464042
72negative thymic T cell selection (GO:0045060)3.50125893
73B cell activation (GO:0042113)3.46601120
74positive regulation of Rap GTPase activity (GO:0032854)3.45478411
75negative regulation of interleukin-12 production (GO:0032695)3.41070679
76regulation of antigen processing and presentation (GO:0002577)3.38560210
77negative T cell selection (GO:0043383)3.31606866
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27380763
79negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.27004694
80T cell selection (GO:0045058)3.25129715
81mast cell activation (GO:0045576)3.25078609
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24998515
83B cell differentiation (GO:0030183)3.23726813
84negative regulation of mononuclear cell proliferation (GO:0032945)3.21968669
85negative regulation of lymphocyte proliferation (GO:0050672)3.21968669
86regulation of interleukin-12 biosynthetic process (GO:0045075)3.17711722
87regulation of glucose import in response to insulin stimulus (GO:2001273)3.16746052
88regulation of isotype switching (GO:0045191)3.15768522
89positive regulation of antigen processing and presentation (GO:0002579)3.15205388
90negative regulation of phagocytosis (GO:0050765)3.13556522
91chronic inflammatory response (GO:0002544)3.13434102
92positive regulation of B cell proliferation (GO:0030890)3.13370296
93response to interleukin-15 (GO:0070672)3.11937454
94tolerance induction (GO:0002507)3.11785570
95cellular response to interferon-gamma (GO:0071346)3.06792775
96B cell mediated immunity (GO:0019724)3.05736051
97negative regulation of myotube differentiation (GO:0010832)3.04957159
98negative regulation of leukocyte proliferation (GO:0070664)3.03368930
99positive regulation of B cell activation (GO:0050871)3.02885299
100neutrophil activation involved in immune response (GO:0002283)3.02237323
101positive regulation of alpha-beta T cell proliferation (GO:0046641)3.01973074
102lymphocyte proliferation (GO:0046651)3.01543470
103branching involved in labyrinthine layer morphogenesis (GO:0060670)3.01205492
104B cell homeostasis (GO:0001782)3.00535560
105mononuclear cell proliferation (GO:0032943)3.00000231
106regulation of isotype switching to IgG isotypes (GO:0048302)2.98410394
107myeloid dendritic cell differentiation (GO:0043011)2.98351058
108negative regulation of complement activation (GO:0045916)2.96765404
109lymphocyte costimulation (GO:0031294)2.96411622
110regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.96113773
111regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95078949
112immune response-activating signal transduction (GO:0002757)2.91680143
113respiratory burst (GO:0045730)2.91022595
114regulation of interferon-alpha production (GO:0032647)2.90994162
115response to interferon-gamma (GO:0034341)2.90459189
116thymic T cell selection (GO:0045061)2.90019183
117activation of immune response (GO:0002253)2.89393438
118response to inactivity (GO:0014854)2.87858420
119cellular response to interleukin-15 (GO:0071350)2.87262152
120dendritic cell chemotaxis (GO:0002407)2.87010264
121negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.86627863
122nucleoside transmembrane transport (GO:1901642)2.85989236
123regulation of Rap GTPase activity (GO:0032317)2.85832028
124surfactant homeostasis (GO:0043129)2.85523316
125mature B cell differentiation involved in immune response (GO:0002313)2.85318253
126hypotonic response (GO:0006971)2.85282717
127NIK/NF-kappaB signaling (GO:0038061)2.84346711
128interferon-gamma-mediated signaling pathway (GO:0060333)2.84203004
129negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82819285
130T cell costimulation (GO:0031295)2.81639847
131production of molecular mediator of immune response (GO:0002440)2.81341583
132regulation of T cell tolerance induction (GO:0002664)2.77912058
133protein-chromophore linkage (GO:0018298)2.77399901
134detection of external biotic stimulus (GO:0098581)2.76776108
135myeloid dendritic cell activation (GO:0001773)2.71632491
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65175714
137regulation of integrin activation (GO:0033623)2.63717929
138positive regulation by symbiont of host defense response (GO:0052509)2.62154479
139modulation by symbiont of host defense response (GO:0052031)2.62154479
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62154479
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62154479
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.62154479
143modulation by symbiont of host immune response (GO:0052553)2.62154479
144COPI coating of Golgi vesicle (GO:0048205)2.62099975
145Golgi transport vesicle coating (GO:0048200)2.62099975
146antigen processing and presentation via MHC class Ib (GO:0002475)2.60623250
147regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60458738
148interferon-gamma secretion (GO:0072643)2.55932647
149regulation of tolerance induction (GO:0002643)2.54445641
150positive regulation of Cdc42 GTPase activity (GO:0043089)2.54334947
151peptide catabolic process (GO:0043171)2.52997678
152T-helper 1 type immune response (GO:0042088)2.52352992
153negative regulation of bone resorption (GO:0045779)2.51330465
154eosinophil chemotaxis (GO:0048245)2.50448893
155dendritic cell migration (GO:0036336)2.50184442
156angiotensin maturation (GO:0002003)2.46423609
157regulation of macrophage chemotaxis (GO:0010758)2.42592001
158immune response-regulating cell surface receptor signaling pathway (GO:0002768)2.40696005
159adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.39536538
160defense response to Gram-negative bacterium (GO:0050829)2.38622449
161macrophage activation involved in immune response (GO:0002281)2.37098046
162virion attachment to host cell (GO:0019062)2.37078612
163adhesion of symbiont to host cell (GO:0044650)2.37078612
164positive regulation of granulocyte chemotaxis (GO:0071624)2.36220144
165cellular extravasation (GO:0045123)2.35687104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.84753980
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.58400932
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.31007892
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.88888468
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.84474289
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.57820901
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.96373647
8MYC_22102868_ChIP-Seq_BL_Human3.83290831
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.66282020
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.63644856
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30768902
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28977282
13TP63_17297297_ChIP-ChIP_HaCaT_Human3.27444349
14RUNX_20019798_ChIP-Seq_JUKART_Human3.24668010
15VDR_21846776_ChIP-Seq_THP-1_Human3.12327342
16MYB_26560356_Chip-Seq_TH2_Human2.96229304
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.91123057
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.84108381
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.78785395
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75472297
21MAF_26560356_Chip-Seq_TH1_Human2.70298734
22E2F7_22180533_ChIP-Seq_HELA_Human2.58086948
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56435690
24MYB_26560356_Chip-Seq_TH1_Human2.54777308
25UTX_26944678_Chip-Seq_JUKART_Human2.24542988
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19935717
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.19196515
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18786310
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12871901
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10883964
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.10056791
32SPI1_23547873_ChIP-Seq_NB4_Human2.04876857
33VDR_24763502_ChIP-Seq_THP-1_Human1.98061608
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97155035
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96916535
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93749234
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87002590
38SCL_19346495_ChIP-Seq_HPC-7_Human1.85572269
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80522033
40GATA1_22025678_ChIP-Seq_K562_Human1.78706925
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76675959
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.75051557
43GATA3_27048872_Chip-Seq_THYMUS_Human1.73887221
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72593881
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69961737
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69083406
47TCF7_22412390_ChIP-Seq_EML_Mouse1.67412676
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.63143226
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59054824
50CIITA_25753668_ChIP-Seq_RAJI_Human1.59029876
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56898901
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.52745115
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51390172
54CLOCK_20551151_ChIP-Seq_293T_Human1.49725953
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47586243
56MAF_26560356_Chip-Seq_TH2_Human1.45574739
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41526942
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41489095
59GATA3_26560356_Chip-Seq_TH2_Human1.40168064
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40026332
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39745551
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36781944
63LXR_22292898_ChIP-Seq_THP-1_Human1.34415416
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33455979
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31143457
66SOX2_20726797_ChIP-Seq_SW620_Human1.28855088
67SPI1_23127762_ChIP-Seq_K562_Human1.27294649
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26010210
69KDM2B_26808549_Chip-Seq_DND41_Human1.25051769
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24939255
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24303555
72PU_27001747_Chip-Seq_BMDM_Mouse1.24182745
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.22356535
74EGR1_19032775_ChIP-ChIP_M12_Human1.20841140
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19715985
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19038073
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18951470
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17230850
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17222683
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.16591014
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16004606
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12448537
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11870861
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07571492
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06456563
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03567802
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03075522
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.02733365
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01755562
90GATA4_25053715_ChIP-Seq_YYC3_Human1.01747638
91PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99417962
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98542603
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98301117
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98225205
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97931926
96RXR_22158963_ChIP-Seq_LIVER_Mouse0.96570058
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96305764
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.95812107
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94201327
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.93370276
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92905202
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92517941
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92477229
104P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92005803
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.91948712
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91731613
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90484061
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89479252
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89410051
110GATA6_25053715_ChIP-Seq_YYC3_Human0.89403136
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89108128
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.88369059
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87483288
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.87202668
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86576892
116RACK7_27058665_Chip-Seq_MCF-7_Human0.85637299
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.85069332
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.84859153
119FOXP3_21729870_ChIP-Seq_TREG_Human0.84801482
120KDM5A_27292631_Chip-Seq_BREAST_Human0.83718630
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79628293
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76813518
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76729783
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75018551
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74027001
126GATA3_26560356_Chip-Seq_TH1_Human0.71706453
127GATA2_19941826_ChIP-Seq_K562_Human0.71616402
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71544299
129VDR_24787735_ChIP-Seq_THP-1_Human0.71111810
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70064125
131P300_27268052_Chip-Seq_Bcells_Human0.70039288
132ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69850790
133SMRT_27268052_Chip-Seq_Bcells_Human0.68782312
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67854891
135GATA1_19941826_ChIP-Seq_K562_Human0.66759956
136SPI1_20517297_ChIP-Seq_HL60_Human0.66675810
137NCOR1_26117541_ChIP-Seq_K562_Human0.66124032
138MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.66066603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.95370425
2MP0001835_abnormal_antigen_presentation5.06432167
3MP0001800_abnormal_humoral_immune4.31783408
4MP0001790_abnormal_immune_system4.30496857
5MP0005387_immune_system_phenotype4.30496857
6MP0003300_gastrointestinal_ulcer3.66694014
7MP0005671_abnormal_response_to3.62003105
8MP0002452_abnormal_antigen_presenting3.27461267
9MP0001873_stomach_inflammation2.97138847
10MP0003763_abnormal_thymus_physiology2.93435134
11MP0005000_abnormal_immune_tolerance2.89827970
12MP0002723_abnormal_immune_serum2.80149779
13MP0002420_abnormal_adaptive_immunity2.79998731
14MP0001819_abnormal_immune_cell2.73576157
15MP0002398_abnormal_bone_marrow2.70650959
16MP0002396_abnormal_hematopoietic_system2.49294634
17MP0000716_abnormal_immune_system2.46155316
18MP0000689_abnormal_spleen_morphology2.37130690
19MP0000685_abnormal_immune_system2.35721664
20MP0005025_abnormal_response_to2.32083946
21MP0001853_heart_inflammation2.25595400
22MP0002148_abnormal_hypersensitivity_rea2.19437961
23MP0005275_abnormal_skin_tensile2.10267366
24MP0009785_altered_susceptibility_to2.09684634
25MP0008438_abnormal_cutaneous_collagen2.06457241
26MP0002722_abnormal_immune_system2.05848509
27MP0003436_decreased_susceptibility_to2.04990248
28MP0002429_abnormal_blood_cell1.98315822
29MP0004782_abnormal_surfactant_physiolog1.88674368
30MP0002419_abnormal_innate_immunity1.87907271
31MP0005310_abnormal_salivary_gland1.83302171
32MP0002933_joint_inflammation1.83245075
33MP0001663_abnormal_digestive_system1.80153182
34MP0000490_abnormal_crypts_of1.78963145
35MP0000703_abnormal_thymus_morphology1.78889445
36MP0006054_spinal_hemorrhage1.73139670
37MP0000465_gastrointestinal_hemorrhage1.72430306
38MP0010155_abnormal_intestine_physiology1.71424339
39MP0002138_abnormal_hepatobiliary_system1.69985994
40MP0001845_abnormal_inflammatory_respons1.64829782
41MP0002405_respiratory_system_inflammati1.62723688
42MP0002166_altered_tumor_susceptibility1.54458727
43MP0003950_abnormal_plasma_membrane1.47165074
44MP0005503_abnormal_tendon_morphology1.44566141
45MP0004947_skin_inflammation1.43919117
46MP0000343_altered_response_to1.34156377
47MP0003693_abnormal_embryo_hatching1.32325158
48MP0004808_abnormal_hematopoietic_stem1.29920083
49MP0003183_abnormal_peptide_metabolism1.29802428
50MP0008004_abnormal_stomach_pH1.28831145
51MP0001879_abnormal_lymphatic_vessel1.27827536
52MP0003656_abnormal_erythrocyte_physiolo1.27374895
53MP0010234_abnormal_vibrissa_follicle1.27081648
54MP0004858_abnormal_nervous_system1.27026639
55MP0010094_abnormal_chromosome_stability1.26509384
56MP0006082_CNS_inflammation1.26156060
57MP0003191_abnormal_cellular_cholesterol1.24153088
58MP0003279_aneurysm1.22485389
59MP0005381_digestive/alimentary_phenotyp1.21100372
60MP0003045_fibrosis1.16302637
61MP0003866_abnormal_defecation1.14548930
62MP0002019_abnormal_tumor_incidence1.13528059
63MP0000604_amyloidosis1.10672380
64MP0001851_eye_inflammation1.09664883
65MP0005390_skeleton_phenotype1.09396554
66MP0009333_abnormal_splenocyte_physiolog1.06260211
67MP0009840_abnormal_foam_cell1.05986821
68MP0005164_abnormal_response_to1.05097587
69MP0001919_abnormal_reproductive_system1.02131501
70MP0002277_abnormal_respiratory_mucosa1.00544152
71MP0002006_tumorigenesis0.98581955
72MP0003828_pulmonary_edema0.98025765
73MP0002928_abnormal_bile_duct0.97423192
74MP0005464_abnormal_platelet_physiology0.96409594
75MP0002796_impaired_skin_barrier0.96296278
76MP0005397_hematopoietic_system_phenotyp0.93204564
77MP0001545_abnormal_hematopoietic_system0.93204564
78MP0003453_abnormal_keratinocyte_physiol0.91936686
79MP0008469_abnormal_protein_level0.89989541
80MP0004510_myositis0.89942172
81MP0001542_abnormal_bone_strength0.89603928
82MP0001533_abnormal_skeleton_physiology0.87983738
83MP0008057_abnormal_DNA_replication0.87549285
84MP0005058_abnormal_lysosome_morphology0.86636729
85MP0003329_amyloid_beta_deposits0.85323043
86MP0009278_abnormal_bone_marrow0.83544790
87MP0002133_abnormal_respiratory_system0.82728650
88MP0005388_respiratory_system_phenotype0.82728650
89MP0003868_abnormal_feces_composition0.80274406
90MP0005165_increased_susceptibility_to0.78829487
91MP0001666_abnormal_nutrient_absorption0.77256997
92MP0004264_abnormal_extraembryonic_tissu0.76881928
93MP0003077_abnormal_cell_cycle0.76236601
94MP0001664_abnormal_digestion0.73299451
95MP0001958_emphysema0.72546931
96MP0005451_abnormal_body_composition0.72059920
97MP0000249_abnormal_blood_vessel0.69545813
98MP0009764_decreased_sensitivity_to0.69510989
99MP0005085_abnormal_gallbladder_physiolo0.68625467
100MP0001216_abnormal_epidermal_layer0.68351320
101MP0002060_abnormal_skin_morphology0.68240713
102MP0000477_abnormal_intestine_morphology0.67555348
103MP0002139_abnormal_hepatobiliary_system0.67139399
104MP0000681_abnormal_thyroid_gland0.67136761
105MP0003091_abnormal_cell_migration0.66359953
106MP0005075_abnormal_melanosome_morpholog0.64886367
107MP0003724_increased_susceptibility_to0.64470252
108MP0000609_abnormal_liver_physiology0.62309132
109MP0008874_decreased_physiological_sensi0.62095314
110MP0001348_abnormal_lacrimal_gland0.61359439
111MP0000013_abnormal_adipose_tissue0.60734633
112MP0000003_abnormal_adipose_tissue0.60486920
113MP0003111_abnormal_nucleus_morphology0.59724881
114MP0009931_abnormal_skin_appearance0.59051644
115MP0002136_abnormal_kidney_physiology0.58511807
116MP0005076_abnormal_cell_differentiation0.57964549
117MP0002693_abnormal_pancreas_physiology0.57632904
118MP0005584_abnormal_enzyme/coenzyme_acti0.57031572
119MP0008873_increased_physiological_sensi0.56651743
120MP0005621_abnormal_cell_physiology0.54899741
121MP0003448_altered_tumor_morphology0.54037791
122MP0009763_increased_sensitivity_to0.53650124
123MP0005023_abnormal_wound_healing0.53395928
124MP0003566_abnormal_cell_adhesion0.52778757
125MP0004957_abnormal_blastocyst_morpholog0.52606835
126MP0005389_reproductive_system_phenotype0.52463562
127MP0000598_abnormal_liver_morphology0.52129870
128MP0000858_altered_metastatic_potential0.51929418
129MP0003075_altered_response_to0.51851238
130MP0002083_premature_death0.51457088
131MP0005408_hypopigmentation0.48904944
132MP0000372_irregular_coat_pigmentation0.48284688
133MP0003795_abnormal_bone_structure0.43569463
134MP0002998_abnormal_bone_remodeling0.40704235
135MP0001191_abnormal_skin_condition0.40275200
136MP0005166_decreased_susceptibility_to0.38245010
137MP0000313_abnormal_cell_death0.37004488
138MP0010352_gastrointestinal_tract_polyps0.35530540

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)8.86720478
2B lymphocytopenia (HP:0010976)8.86720478
3Agammaglobulinemia (HP:0004432)7.86685741
4Prostate neoplasm (HP:0100787)6.74219809
5Recurrent bronchitis (HP:0002837)6.35047530
6Cellulitis (HP:0100658)5.93573355
7Systemic lupus erythematosus (HP:0002725)5.58670973
8Abnormality of macrophages (HP:0004311)5.53266136
9Meningitis (HP:0001287)5.41456602
10Recurrent sinusitis (HP:0011108)5.31510994
11Panhypogammaglobulinemia (HP:0003139)5.30733414
12Recurrent viral infections (HP:0004429)5.25739151
13Verrucae (HP:0200043)5.12097532
14Papilloma (HP:0012740)5.12097532
15Thyroiditis (HP:0100646)5.03534282
16Hypoplasia of the thymus (HP:0000778)4.80386329
17Gastrointestinal stroma tumor (HP:0100723)4.70494731
18Colitis (HP:0002583)4.55823489
19Severe combined immunodeficiency (HP:0004430)4.25199670
20IgM deficiency (HP:0002850)4.23530406
21Pulmonary infiltrates (HP:0002113)3.90922907
22Retrobulbar optic neuritis (HP:0100654)3.86141002
23Optic neuritis (HP:0100653)3.86141002
24Vasculitis (HP:0002633)3.85086591
25Inflammation of the large intestine (HP:0002037)3.77091984
26Combined immunodeficiency (HP:0005387)3.72536947
27Chronic obstructive pulmonary disease (HP:0006510)3.71100321
28Obstructive lung disease (HP:0006536)3.71100321
29Recurrent pneumonia (HP:0006532)3.68995898
30Myositis (HP:0100614)3.65972021
31Bronchitis (HP:0012387)3.63845793
32Sepsis (HP:0100806)3.62209146
33Gastrointestinal inflammation (HP:0004386)3.62098419
34Abnormality of complement system (HP:0005339)3.60317462
35Malnutrition (HP:0004395)3.59196681
36T lymphocytopenia (HP:0005403)3.38050739
37Glomerulonephritis (HP:0000099)3.36861962
38Increased IgE level (HP:0003212)3.36395169
39Complement deficiency (HP:0004431)3.36128782
40Osteomyelitis (HP:0002754)3.34422754
41Gastrointestinal infarctions (HP:0005244)3.34115460
42IgG deficiency (HP:0004315)3.33080906
43Orchitis (HP:0100796)3.28070006
44Spontaneous hematomas (HP:0007420)3.27851741
45Premature loss of primary teeth (HP:0006323)3.27725066
46Restrictive lung disease (HP:0002091)3.23641919
47Abnormality of T cell number (HP:0011839)3.21389893
48Recurrent fungal infections (HP:0002841)3.20421526
49IgA deficiency (HP:0002720)3.18926301
50Chronic sinusitis (HP:0011109)3.18850509
51Recurrent lower respiratory tract infections (HP:0002783)3.17227857
52Gangrene (HP:0100758)3.14334564
53Abnormality of the prostate (HP:0008775)3.08134250
54Skin rash (HP:0000988)3.02305349
55Lymphopenia (HP:0001888)2.97319736
56Recurrent otitis media (HP:0000403)2.96195915
57Abnormality of T cells (HP:0002843)2.95712263
58Urticaria (HP:0001025)2.89036250
59Small epiphyses (HP:0010585)2.86034805
60Hyperactive renin-angiotensin system (HP:0000841)2.84917446
61Emphysema (HP:0002097)2.84298607
62Mediastinal lymphadenopathy (HP:0100721)2.83825304
63Gingivitis (HP:0000230)2.83599740
64Nephritis (HP:0000123)2.83456723
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.83361090
66Keratoconjunctivitis sicca (HP:0001097)2.75252521
67Hemoptysis (HP:0002105)2.74920231
68Abnormality of male internal genitalia (HP:0000022)2.73610246
69Chronic otitis media (HP:0000389)2.72775300
70Recurrent abscess formation (HP:0002722)2.72314749
71Pulmonary embolism (HP:0002204)2.69374980
72Eosinophilia (HP:0001880)2.69362152
73Chest pain (HP:0100749)2.68332817
74Alopecia of scalp (HP:0002293)2.66427699
75Abnormality of T cell physiology (HP:0011840)2.64220786
76Chronic diarrhea (HP:0002028)2.61165110
77Mitral stenosis (HP:0001718)2.58757661
78Abnormality of small intestinal villus morphology (HP:0011472)2.53546948
79Villous atrophy (HP:0011473)2.53546948
80Abnormality of the nasal mucosa (HP:0000433)2.50945273
81Keratoconjunctivitis (HP:0001096)2.50356444
82Hypoproteinemia (HP:0003075)2.49377852
83Autoimmune hemolytic anemia (HP:0001890)2.48296845
84Eczematoid dermatitis (HP:0000976)2.47704761
85Recurrent gram-negative bacterial infections (HP:0005420)2.44003343
86Ureteral stenosis (HP:0000071)2.43297985
87Lymphoma (HP:0002665)2.42312534
88Neutropenia (HP:0001875)2.38753558
89Hypergammaglobulinemia (HP:0010702)2.38276449
90Osteolytic defects of the phalanges of the hand (HP:0009771)2.37926695
91Osteolytic defects of the hand bones (HP:0009699)2.37926695
92Periodontitis (HP:0000704)2.37022362
93Arterial thrombosis (HP:0004420)2.35454317
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.33863248
95Recurrent cutaneous fungal infections (HP:0011370)2.31243263
96Chronic mucocutaneous candidiasis (HP:0002728)2.31243263
97Recurrent bacterial skin infections (HP:0005406)2.30812092
98Neoplasm of the lung (HP:0100526)2.27706723
99Right ventricular cardiomyopathy (HP:0011663)2.27271256
100Abnormality of eosinophils (HP:0001879)2.25368522
101Fragile skin (HP:0001030)2.23287796
102Thrombophlebitis (HP:0004418)2.23206338
103Granulocytopenia (HP:0001913)2.22003761
104Skin ulcer (HP:0200042)2.19611767
105Stomatitis (HP:0010280)2.18316733
106Viral hepatitis (HP:0006562)2.17605989
107Ankyloglossia (HP:0010296)2.17011461
108Abnormality of the pleura (HP:0002103)2.16319735
109Pustule (HP:0200039)2.15669752
110Ureteral obstruction (HP:0006000)2.14582601
111Aplasia/Hypoplasia of the thymus (HP:0010515)2.13405942
112Encephalitis (HP:0002383)2.13087107
113Hypermelanotic macule (HP:0001034)2.12211170
114Increased IgM level (HP:0003496)2.09336357
115Metaphyseal cupping (HP:0003021)2.08197283
116Interstitial pulmonary disease (HP:0006530)2.06121336
117Duplicated collecting system (HP:0000081)2.05476305
118Purpura (HP:0000979)2.05455955
119Thrombocytosis (HP:0001894)2.04674087
120Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03895845
121Vertebral arch anomaly (HP:0008438)2.01179516
122Atrophic scars (HP:0001075)1.98526980
123Abnormality of oral frenula (HP:0000190)1.96559848
124Aortic dissection (HP:0002647)1.95467236
125Decreased circulating renin level (HP:0003351)1.94838479
126Neoplasm of the respiratory system (HP:0100606)1.93970758
127Peritonitis (HP:0002586)1.93257028
128Polyneuropathy (HP:0001271)1.92514660
129Entropion (HP:0000621)1.91863157
130Seborrheic dermatitis (HP:0001051)1.90731520
131Gingival bleeding (HP:0000225)1.89866991
132Limb hypertonia (HP:0002509)1.88730353
133Leukocytosis (HP:0001974)1.86497923
134Recurrent skin infections (HP:0001581)1.86239852
135Pancreatitis (HP:0001733)1.85848025
136Bronchiectasis (HP:0002110)1.81485284
137Elevated erythrocyte sedimentation rate (HP:0003565)1.80121375
138Anorexia (HP:0002039)1.78928163
139Erythroderma (HP:0001019)1.77790796
140Hypokinesia (HP:0002375)1.77181136
141Pulmonary fibrosis (HP:0002206)1.76141918
142Glomerulopathy (HP:0100820)1.74029026
143Arthralgia (HP:0002829)1.72906925
144Autoimmune thrombocytopenia (HP:0001973)1.72812669
145Subacute progressive viral hepatitis (HP:0006572)1.69913804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.85338501
2ERN15.21651546
3MAP4K14.39706429
4MAP3K103.60083068
5PRPF4B3.27902446
6GRK63.21787946
7MST1R3.08463865
8SYK2.45461068
9TAOK32.33505677
10EPHA32.32965305
11BUB12.25061403
12CSF1R2.15058123
13MAP3K142.06883364
14EIF2AK31.88470284
15CDC42BPA1.88396790
16EPHB11.88276363
17RIPK11.83457228
18BTK1.81034888
19MAP3K131.71185412
20EEF2K1.68809343
21RIPK41.68338128
22PIK3CA1.51118630
23FES1.50509226
24JAK31.49775232
25MST41.48510761
26LYN1.44608425
27WNK11.38068142
28PDGFRA1.35768862
29STK101.35316356
30PKN21.34120875
31JAK11.33480909
32ITK1.32629485
33TYK21.31191779
34KIT1.28856126
35NEK21.28051288
36TBK11.27246343
37CCNB11.26566245
38SIK21.22652918
39NME21.19673399
40STK241.15136707
41MAP3K11.14849429
42HCK1.13915807
43MARK31.13398274
44LCK1.12290940
45TEC1.11464606
46MAPK41.11408061
47LRRK21.09998753
48YES11.08606705
49IRAK41.08076095
50BMPR21.03162090
51IRAK10.99718204
52DDR20.97871801
53MET0.94779224
54BLK0.93019809
55FER0.91446070
56STK40.91064826
57CDK60.90797735
58FGR0.87828273
59PRKCQ0.87604081
60EIF2AK10.87207766
61TESK20.84067049
62PIM10.82762918
63TAOK10.82422873
64CDK40.81477313
65JAK20.81205185
66FGFR30.80216619
67CHUK0.80183295
68IKBKE0.79740942
69IKBKB0.79567359
70NLK0.79267465
71SMG10.79164880
72IRAK30.78652361
73MAP3K30.78506489
74CSK0.78296678
75FLT30.78183975
76PDK10.76034641
77SRPK10.75071792
78TRIB30.74727760
79TAOK20.74356675
80EPHA20.69273274
81PRKG20.68434568
82KSR20.66727788
83NEK90.66326930
84RPS6KB20.66244788
85MAP2K30.64977584
86ZAP700.64806684
87TNK20.64677752
88MAP3K60.64234408
89SCYL20.62715188
90TLK10.62463356
91HIPK20.61673659
92MATK0.61612163
93NUAK10.61517832
94RET0.61403570
95DMPK0.59984941
96PTK60.59147319
97PDGFRB0.58441894
98FYN0.57914739
99MAPK110.55759705
100CLK10.55004137
101SIK30.54152520
102BRSK20.53904121
103PAK40.51218269
104PKN10.51195825
105MAPK70.50633421
106TGFBR10.49936815
107CSNK1A1L0.49221140
108TGFBR20.48031948
109MAP3K80.47934923
110CSNK1G30.47685067
111PRKCD0.47681297
112MAPK120.47565007
113RPS6KB10.47157655
114MYLK0.47153720
115BRSK10.47153459
116CDK120.45748675
117EPHB20.44969980
118PLK30.44505395
119CHEK20.44473150
120FGFR40.44334037
121ACVR1B0.43990859
122GRK50.43824055
123ABL10.42936673
124IGF1R0.41537088
125KDR0.40260913
126ALK0.40059929
127UHMK10.39869605
128ATR0.37021903
129CSNK1G10.36880980
130PIK3CG0.36520881
131MAP2K20.36368845
132SIK10.36237181
133PRKCH0.35788218
134WEE10.33711082
135OXSR10.33200338
136EGFR0.32871388
137PDPK10.32667537
138FRK0.32204356
139PRKD20.31897134
140MAP3K20.31746952
141LMTK20.31633455
142MAPKAPK20.30282698
143GRK10.29961717
144MELK0.29952091
145INSR0.29691673
146CDK190.28445509
147AURKB0.28211228

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.89300042
2Intestinal immune network for IgA production_Homo sapiens_hsa046725.15435311
3B cell receptor signaling pathway_Homo sapiens_hsa046624.27427432
4Autoimmune thyroid disease_Homo sapiens_hsa053203.86348410
5Asthma_Homo sapiens_hsa053103.52738926
6Allograft rejection_Homo sapiens_hsa053303.32897189
7Non-homologous end-joining_Homo sapiens_hsa034503.30845670
8Graft-versus-host disease_Homo sapiens_hsa053323.05935716
9Leishmaniasis_Homo sapiens_hsa051402.64323695
10Type I diabetes mellitus_Homo sapiens_hsa049402.48988372
11Hematopoietic cell lineage_Homo sapiens_hsa046402.12303500
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.11272423
13T cell receptor signaling pathway_Homo sapiens_hsa046602.08912893
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94689714
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84254875
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76239391
17Osteoclast differentiation_Homo sapiens_hsa043801.65752433
18Other glycan degradation_Homo sapiens_hsa005111.42760494
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42149816
20Protein export_Homo sapiens_hsa030601.40856792
21African trypanosomiasis_Homo sapiens_hsa051431.40712346
22Measles_Homo sapiens_hsa051621.38528349
23Malaria_Homo sapiens_hsa051441.34931697
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30391331
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29937703
26Complement and coagulation cascades_Homo sapiens_hsa046101.25570849
27Tuberculosis_Homo sapiens_hsa051521.24924770
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23774863
29Toxoplasmosis_Homo sapiens_hsa051451.22947207
30Phagosome_Homo sapiens_hsa041451.22738088
31Pertussis_Homo sapiens_hsa051331.22334978
32Staphylococcus aureus infection_Homo sapiens_hsa051501.20207699
33Antigen processing and presentation_Homo sapiens_hsa046121.19028898
34Shigellosis_Homo sapiens_hsa051311.14430615
35Chemokine signaling pathway_Homo sapiens_hsa040621.14022851
36Hepatitis B_Homo sapiens_hsa051611.08808466
37Arginine biosynthesis_Homo sapiens_hsa002201.07463585
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.07335048
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03165404
40Systemic lupus erythematosus_Homo sapiens_hsa053221.01604991
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99284767
42Apoptosis_Homo sapiens_hsa042100.98682322
43p53 signaling pathway_Homo sapiens_hsa041150.98313711
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97599129
45Base excision repair_Homo sapiens_hsa034100.96497500
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95945865
47Herpes simplex infection_Homo sapiens_hsa051680.95163210
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.93679194
49Platelet activation_Homo sapiens_hsa046110.92794717
50Viral myocarditis_Homo sapiens_hsa054160.90149133
51Sulfur metabolism_Homo sapiens_hsa009200.89203625
52Chronic myeloid leukemia_Homo sapiens_hsa052200.85166313
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.84993355
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83639047
55Non-small cell lung cancer_Homo sapiens_hsa052230.83042020
56Epstein-Barr virus infection_Homo sapiens_hsa051690.82785425
57Pancreatic cancer_Homo sapiens_hsa052120.81685097
58MicroRNAs in cancer_Homo sapiens_hsa052060.81088753
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79993997
60N-Glycan biosynthesis_Homo sapiens_hsa005100.78940560
61Long-term potentiation_Homo sapiens_hsa047200.76771499
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74217168
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71160840
64Protein digestion and absorption_Homo sapiens_hsa049740.70586701
65Viral carcinogenesis_Homo sapiens_hsa052030.69867403
66Legionellosis_Homo sapiens_hsa051340.69572589
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69335798
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.68255425
69FoxO signaling pathway_Homo sapiens_hsa040680.68016114
70Influenza A_Homo sapiens_hsa051640.67603154
71Ribosome_Homo sapiens_hsa030100.65718790
72Lysosome_Homo sapiens_hsa041420.65560336
73Fructose and mannose metabolism_Homo sapiens_hsa000510.62685056
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58995059
75Small cell lung cancer_Homo sapiens_hsa052220.58479129
76Mineral absorption_Homo sapiens_hsa049780.56425305
77Prion diseases_Homo sapiens_hsa050200.54453670
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54167205
79Caffeine metabolism_Homo sapiens_hsa002320.53036797
80Prolactin signaling pathway_Homo sapiens_hsa049170.51175639
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50813592
82HTLV-I infection_Homo sapiens_hsa051660.48815166
83Pancreatic secretion_Homo sapiens_hsa049720.48153605
84Fat digestion and absorption_Homo sapiens_hsa049750.46861986
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46465754
86Acute myeloid leukemia_Homo sapiens_hsa052210.45751869
87Renal cell carcinoma_Homo sapiens_hsa052110.45442789
88HIF-1 signaling pathway_Homo sapiens_hsa040660.42339688
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42304741
90Insulin resistance_Homo sapiens_hsa049310.40681183
91Arachidonic acid metabolism_Homo sapiens_hsa005900.39090650
92Alcoholism_Homo sapiens_hsa050340.37208372
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36926329
94TNF signaling pathway_Homo sapiens_hsa046680.36611959
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36385201
96Colorectal cancer_Homo sapiens_hsa052100.34402436
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34330567
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.33500764
99Glioma_Homo sapiens_hsa052140.33166682
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32307131
101Galactose metabolism_Homo sapiens_hsa000520.30244017
102Hepatitis C_Homo sapiens_hsa051600.29926845
103mRNA surveillance pathway_Homo sapiens_hsa030150.29243280
104GnRH signaling pathway_Homo sapiens_hsa049120.29138273
105MAPK signaling pathway_Homo sapiens_hsa040100.28735402
106Oocyte meiosis_Homo sapiens_hsa041140.28726084
107VEGF signaling pathway_Homo sapiens_hsa043700.28646906
108Prostate cancer_Homo sapiens_hsa052150.27761380
109Endocytosis_Homo sapiens_hsa041440.27706891
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27453029
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27357286
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.26300395
113Cell cycle_Homo sapiens_hsa041100.25866565
114Bladder cancer_Homo sapiens_hsa052190.25434927
115Spliceosome_Homo sapiens_hsa030400.24564421
116mTOR signaling pathway_Homo sapiens_hsa041500.24495640
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23785626
118Starch and sucrose metabolism_Homo sapiens_hsa005000.23340352
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23048664
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19845377
121Thyroid hormone synthesis_Homo sapiens_hsa049180.18158523
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.16747150
123Salmonella infection_Homo sapiens_hsa051320.15310313
124Proteoglycans in cancer_Homo sapiens_hsa052050.14089924
125Renin-angiotensin system_Homo sapiens_hsa046140.13454198
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12795098
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11710199
128Amphetamine addiction_Homo sapiens_hsa050310.10846653
129ErbB signaling pathway_Homo sapiens_hsa040120.10770883
130Amoebiasis_Homo sapiens_hsa051460.09635186
131Rheumatoid arthritis_Homo sapiens_hsa053230.09327676
132Lysine degradation_Homo sapiens_hsa003100.08780979
133Type II diabetes mellitus_Homo sapiens_hsa049300.08360130

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