IGHV1-46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)8.90027191
2positive regulation of respiratory burst (GO:0060267)8.61202200
3glomerular filtration (GO:0003094)7.40848812
4renal filtration (GO:0097205)6.71213798
5protein activation cascade (GO:0072376)6.55996715
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.82750719
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.76078628
8regulation of respiratory burst (GO:0060263)5.64125394
9immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.57317468
10Fc-gamma receptor signaling pathway (GO:0038094)5.57317468
11Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.57317468
12Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.53920666
13antigen processing and presentation of endogenous antigen (GO:0019883)5.43140418
14humoral immune response (GO:0006959)5.03131539
15antimicrobial humoral response (GO:0019730)4.61692012
16antibacterial humoral response (GO:0019731)4.53804001
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33710499
18retina homeostasis (GO:0001895)4.32888409
19detection of bacterium (GO:0016045)4.03454555
20negative regulation of cell killing (GO:0031342)3.98861635
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98861635
22regulation of cellular extravasation (GO:0002691)3.97816279
23detection of other organism (GO:0098543)3.94635318
24interferon-gamma-mediated signaling pathway (GO:0060333)3.66344912
25cellular response to type I interferon (GO:0071357)3.65051687
26type I interferon signaling pathway (GO:0060337)3.65051687
27response to type I interferon (GO:0034340)3.63179222
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.58814241
29immunoglobulin mediated immune response (GO:0016064)3.57181176
30germinal center formation (GO:0002467)3.55851164
31immune response-activating cell surface receptor signaling pathway (GO:0002429)3.52241668
32positive regulation of gamma-delta T cell activation (GO:0046645)3.47796989
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37744034
34regulation of antigen processing and presentation (GO:0002577)3.34002146
35chronic inflammatory response (GO:0002544)3.13863371
36positive regulation of antigen processing and presentation (GO:0002579)3.12541821
37positive regulation of Cdc42 GTPase activity (GO:0043089)3.07906681
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04433003
39cellular response to interferon-gamma (GO:0071346)2.96290432
40detection of external biotic stimulus (GO:0098581)2.93101004
41angiotensin maturation (GO:0002003)2.86285422
42regulation of T cell tolerance induction (GO:0002664)2.83522031
43regulation of integrin activation (GO:0033623)2.83169095
44dendritic cell chemotaxis (GO:0002407)2.82971733
45response to interferon-gamma (GO:0034341)2.81213423
46NIK/NF-kappaB signaling (GO:0038061)2.80806582
47regulation of regulatory T cell differentiation (GO:0045589)2.75148830
48establishment of skin barrier (GO:0061436)2.73314329
49immune response-activating signal transduction (GO:0002757)2.72486014
50positive regulation of pseudopodium assembly (GO:0031274)2.72093074
51negative regulation of myotube differentiation (GO:0010832)2.70018471
52activation of immune response (GO:0002253)2.68734483
53regulation of water loss via skin (GO:0033561)2.66735030
54protein-chromophore linkage (GO:0018298)2.65146302
55B cell mediated immunity (GO:0019724)2.64597372
56regulation of gamma-delta T cell activation (GO:0046643)2.64415807
57myeloid dendritic cell differentiation (GO:0043011)2.63292549
58desmosome organization (GO:0002934)2.60716062
59production of molecular mediator of immune response (GO:0002440)2.55785686
60positive regulation of T cell migration (GO:2000406)2.55301339
61interferon-gamma secretion (GO:0072643)2.54986444
62T-helper 1 type immune response (GO:0042088)2.54819440
63regulation of tolerance induction (GO:0002643)2.54434717
64regulation of T cell migration (GO:2000404)2.52140968
65surfactant homeostasis (GO:0043129)2.51728588
66regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50760027
67dendritic cell migration (GO:0036336)2.49222263
68detection of biotic stimulus (GO:0009595)2.47694108
69adhesion of symbiont to host cell (GO:0044650)2.47330593
70virion attachment to host cell (GO:0019062)2.47330593
71regulation of gamma-delta T cell differentiation (GO:0045586)2.44301214
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44212480
73positive regulation by organism of defense response of other organism involved in symbiotic interact2.44212480
74modulation by symbiont of host immune response (GO:0052553)2.44212480
75positive regulation by symbiont of host defense response (GO:0052509)2.44212480
76modulation by symbiont of host defense response (GO:0052031)2.44212480
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44212480
78regulation of B cell receptor signaling pathway (GO:0050855)2.43373445
79antigen processing and presentation via MHC class Ib (GO:0002475)2.43051341
80leukocyte aggregation (GO:0070486)2.42956672
81eosinophil chemotaxis (GO:0048245)2.42869688
82regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.42578963
83maintenance of gastrointestinal epithelium (GO:0030277)2.41940820
84myeloid dendritic cell activation (GO:0001773)2.41804428
85regulation of pseudopodium assembly (GO:0031272)2.41123510
86T cell costimulation (GO:0031295)2.39431558
87keratinization (GO:0031424)2.38949167
88response to interferon-beta (GO:0035456)2.36229489
89lymphocyte costimulation (GO:0031294)2.35728145
90defense response to Gram-negative bacterium (GO:0050829)2.35492326
91bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34364033
92multicellular organismal water homeostasis (GO:0050891)2.33972907
93negative regulation of innate immune response (GO:0045824)2.33102454
94positive regulation of lymphocyte migration (GO:2000403)2.30481413
95positive regulation of granulocyte chemotaxis (GO:0071624)2.29569979
96regulation of necrotic cell death (GO:0010939)2.29264532
97regulation of lymphocyte migration (GO:2000401)2.28450027
98regulation of monocyte chemotaxis (GO:0090025)2.27882506
99negative regulation of glycoprotein biosynthetic process (GO:0010561)2.27405781
100complement activation, classical pathway (GO:0006958)11.1803586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.55477489
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.94450489
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.74626767
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.67911919
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.37446136
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.10935324
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84151545
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.73385484
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.28661112
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27300218
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16164445
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06843479
13CDX2_20551321_ChIP-Seq_CACO-2_Human1.97351936
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92194520
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91955301
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.89164821
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87994033
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86954008
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83298533
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76491272
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71396304
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71319212
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71213205
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71092220
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70342574
26RUNX_20019798_ChIP-Seq_JUKART_Human1.69486311
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.69420533
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68493977
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56380629
30VDR_24763502_ChIP-Seq_THP-1_Human1.52641938
31LXR_22292898_ChIP-Seq_THP-1_Human1.51998487
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46904840
33MYB_26560356_Chip-Seq_TH2_Human1.45206714
34CLOCK_20551151_ChIP-Seq_293T_Human1.44666339
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44237635
36SOX2_20726797_ChIP-Seq_SW620_Human1.41935577
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41654855
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39845251
39VDR_21846776_ChIP-Seq_THP-1_Human1.38473466
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.36778500
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35961082
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35432576
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33645977
44MAF_26560356_Chip-Seq_TH1_Human1.31386037
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31247800
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.29149548
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.28990163
48EGR1_19032775_ChIP-ChIP_M12_Human1.27945845
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.25977748
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23193348
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22573875
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.21080984
53TCF7_22412390_ChIP-Seq_EML_Mouse1.21056421
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20388504
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20236787
56MYB_26560356_Chip-Seq_TH1_Human1.19558973
57SPI1_23127762_ChIP-Seq_K562_Human1.19456009
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.17588633
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17392781
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17341714
61GATA4_25053715_ChIP-Seq_YYC3_Human1.17282009
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.15930273
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.14877796
64VDR_24787735_ChIP-Seq_THP-1_Human1.14729937
65SPI1_23547873_ChIP-Seq_NB4_Human1.14718944
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14660288
67UTX_26944678_Chip-Seq_JUKART_Human1.14489783
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12728621
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12158806
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10789350
71GATA1_19941826_ChIP-Seq_K562_Human1.10640033
72MYC_22102868_ChIP-Seq_BL_Human1.09691405
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08881026
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08122758
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05866144
76RACK7_27058665_Chip-Seq_MCF-7_Human1.04046614
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03447244
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.02747097
79GATA6_25053715_ChIP-Seq_YYC3_Human1.02329489
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02078393
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98359237
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97040710
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96121786
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94629059
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92757604
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92053351
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91499031
88GATA3_27048872_Chip-Seq_THYMUS_Human0.90249963
89PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90048887
90SCL_19346495_ChIP-Seq_HPC-7_Human0.89178835
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88979277
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88660102
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88582115
94GATA2_19941826_ChIP-Seq_K562_Human0.87081499
95RUNX1_27514584_Chip-Seq_MCF-7_Human0.86641706
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85404497
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84760120
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.84217558
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82934998
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82054337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.73737908
2MP0003303_peritoneal_inflammation3.34426302
3MP0003436_decreased_susceptibility_to3.27872146
4MP0010234_abnormal_vibrissa_follicle3.13428485
5MP0001835_abnormal_antigen_presentation2.91224078
6MP0010155_abnormal_intestine_physiology2.77328974
7MP0005275_abnormal_skin_tensile2.77282073
8MP0005387_immune_system_phenotype2.74470324
9MP0001790_abnormal_immune_system2.74470324
10MP0001800_abnormal_humoral_immune2.52243911
11MP0005025_abnormal_response_to2.42010142
12MP0000685_abnormal_immune_system2.36756065
13MP0005671_abnormal_response_to2.34174528
14MP0009785_altered_susceptibility_to2.33087873
15MP0000465_gastrointestinal_hemorrhage2.29488391
16MP0003300_gastrointestinal_ulcer2.24657768
17MP0005000_abnormal_immune_tolerance2.20938705
18MP0004264_abnormal_extraembryonic_tissu2.18634791
19MP0001533_abnormal_skeleton_physiology2.10137358
20MP0002796_impaired_skin_barrier2.07035788
21MP0003866_abnormal_defecation2.03964635
22MP0002452_abnormal_antigen_presenting1.98163321
23MP0002148_abnormal_hypersensitivity_rea1.94687530
24MP0004947_skin_inflammation1.92381939
25MP0002723_abnormal_immune_serum1.88915894
26MP0002419_abnormal_innate_immunity1.85790171
27MP0005166_decreased_susceptibility_to1.84474283
28MP0001819_abnormal_immune_cell1.80248450
29MP0002420_abnormal_adaptive_immunity1.78513706
30MP0002138_abnormal_hepatobiliary_system1.77618652
31MP0001873_stomach_inflammation1.76275345
32MP0004782_abnormal_surfactant_physiolog1.73958992
33MP0002166_altered_tumor_susceptibility1.72502696
34MP0006082_CNS_inflammation1.72484817
35MP0003763_abnormal_thymus_physiology1.64945764
36MP0001845_abnormal_inflammatory_respons1.63007849
37MP0010352_gastrointestinal_tract_polyps1.62466633
38MP0009333_abnormal_splenocyte_physiolog1.45502212
39MP0003183_abnormal_peptide_metabolism1.44509472
40MP0003191_abnormal_cellular_cholesterol1.39647136
41MP0008438_abnormal_cutaneous_collagen1.37022592
42MP0004858_abnormal_nervous_system1.36468899
43MP0001663_abnormal_digestive_system1.35310980
44MP0003448_altered_tumor_morphology1.33194640
45MP0005503_abnormal_tendon_morphology1.31316270
46MP0008004_abnormal_stomach_pH1.31302313
47MP0005023_abnormal_wound_healing1.29952848
48MP0005310_abnormal_salivary_gland1.28708098
49MP0000716_abnormal_immune_system1.28533190
50MP0003453_abnormal_keratinocyte_physiol1.26929353
51MP0002006_tumorigenesis1.26817648
52MP0003075_altered_response_to1.22829938
53MP0000858_altered_metastatic_potential1.21162325
54MP0002139_abnormal_hepatobiliary_system1.20125550
55MP0003828_pulmonary_edema1.17783890
56MP0002933_joint_inflammation1.17777348
57MP0001851_eye_inflammation1.17506453
58MP0002398_abnormal_bone_marrow1.16539422
59MP0002405_respiratory_system_inflammati1.15705951
60MP0002998_abnormal_bone_remodeling1.13873581
61MP0000343_altered_response_to1.10832400
62MP0005390_skeleton_phenotype1.10499821
63MP0005464_abnormal_platelet_physiology1.08365015
64MP0005409_darkened_coat_color1.06788667
65MP0000490_abnormal_crypts_of1.06606151
66MP0008469_abnormal_protein_level1.06187666
67MP0010678_abnormal_skin_adnexa1.05969971
68MP0001216_abnormal_epidermal_layer1.05156383
69MP0000604_amyloidosis1.04055102
70MP0003045_fibrosis1.03862046
71MP0003279_aneurysm1.03493209
72MP0000477_abnormal_intestine_morphology1.02179925
73MP0002277_abnormal_respiratory_mucosa1.01552056
74MP0009840_abnormal_foam_cell1.00486114
75MP0005381_digestive/alimentary_phenotyp1.00280233
76MP0002429_abnormal_blood_cell0.98662385
77MP0000579_abnormal_nail_morphology0.97424053
78MP0005164_abnormal_response_to0.96053593
79MP0009764_decreased_sensitivity_to0.95362489
80MP0003566_abnormal_cell_adhesion0.94903257
81MP0005360_urolithiasis0.89292318
82MP0001666_abnormal_nutrient_absorption0.89065670
83MP0000249_abnormal_blood_vessel0.88616799
84MP0002722_abnormal_immune_system0.88044310
85MP0008260_abnormal_autophagy0.85529523
86MP0002060_abnormal_skin_morphology0.84615044
87MP0004510_myositis0.84437756
88MP0005085_abnormal_gallbladder_physiolo0.83976156
89MP0000689_abnormal_spleen_morphology0.83691236
90MP0003329_amyloid_beta_deposits0.83213458
91MP0005501_abnormal_skin_physiology0.82381264
92MP0009278_abnormal_bone_marrow0.81398333
93MP0001664_abnormal_digestion0.80636021
94MP0000678_abnormal_parathyroid_gland0.80292851
95MP0005388_respiratory_system_phenotype0.79685192
96MP0002133_abnormal_respiratory_system0.79685192
97MP0002009_preneoplasia0.79620454
98MP0003868_abnormal_feces_composition0.79118516
99MP0005058_abnormal_lysosome_morphology0.77966099
100MP0005451_abnormal_body_composition0.77570656

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.92126289
2Prostate neoplasm (HP:0100787)5.81864055
3Abnormality of macrophages (HP:0004311)4.87291257
4Eczematoid dermatitis (HP:0000976)4.76780665
5Increased IgE level (HP:0003212)4.34536842
6Malnutrition (HP:0004395)4.25665124
7Abnormality of complement system (HP:0005339)3.95195119
8Abnormality of the prostate (HP:0008775)3.90633177
9Alopecia of scalp (HP:0002293)3.79414069
10Vasculitis (HP:0002633)3.72590981
11Complement deficiency (HP:0004431)3.63749042
12Glomerulonephritis (HP:0000099)3.61557422
13Recurrent bronchitis (HP:0002837)3.32715040
14Recurrent bacterial skin infections (HP:0005406)3.27829853
15Thick nail (HP:0001805)3.10821962
16Spontaneous hematomas (HP:0007420)3.09807046
17Nephritis (HP:0000123)3.01519274
18Hyperactive renin-angiotensin system (HP:0000841)2.99004376
19Gastrointestinal stroma tumor (HP:0100723)2.98732721
20Leukocytosis (HP:0001974)2.97773434
21Abnormality of cells of the lymphoid lineage (HP:0012140)2.93629405
22Premature loss of primary teeth (HP:0006323)2.91083727
23Myositis (HP:0100614)2.91034088
24Gastrointestinal infarctions (HP:0005244)2.90402664
25Recurrent abscess formation (HP:0002722)2.90198943
26Abnormality of nail color (HP:0100643)2.89334737
27Urticaria (HP:0001025)2.84855493
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.80566451
29Right ventricular cardiomyopathy (HP:0011663)2.76837384
30Agammaglobulinemia (HP:0004432)2.73779114
31Skin rash (HP:0000988)2.73337125
32Gingivitis (HP:0000230)2.72692113
33Orchitis (HP:0100796)2.71293724
34Colitis (HP:0002583)2.71245183
35Elevated erythrocyte sedimentation rate (HP:0003565)2.69132412
36Meningitis (HP:0001287)2.67338040
37Abnormality of the nasal mucosa (HP:0000433)2.63818875
38Palmoplantar hyperkeratosis (HP:0000972)2.59486048
39Cellulitis (HP:0100658)2.58562039
40Inflammation of the large intestine (HP:0002037)2.51754471
41Pustule (HP:0200039)2.51309325
42Hypergammaglobulinemia (HP:0010702)2.50049640
43Hemoptysis (HP:0002105)2.42196891
44Chronic otitis media (HP:0000389)2.41853335
45Recurrent gram-negative bacterial infections (HP:0005420)2.40555653
46Osteomyelitis (HP:0002754)2.40458035
47Gastrointestinal inflammation (HP:0004386)2.40348789
48Palmar hyperkeratosis (HP:0010765)2.39745652
49Abnormality of small intestinal villus morphology (HP:0011472)2.39691742
50Villous atrophy (HP:0011473)2.39691742
51Emphysema (HP:0002097)2.38731620
52Abnormal hair laboratory examination (HP:0003328)2.37385868
53Chronic diarrhea (HP:0002028)2.33662049
54Plantar hyperkeratosis (HP:0007556)2.31504520
55Abnormality of male internal genitalia (HP:0000022)2.30271305
56Mediastinal lymphadenopathy (HP:0100721)2.29587213
57Abnormality of B cell number (HP:0010975)2.29553580
58Xerostomia (HP:0000217)2.29141455
59Obstructive lung disease (HP:0006536)2.27635088
60Chronic obstructive pulmonary disease (HP:0006510)2.27635088
61Interstitial pulmonary disease (HP:0006530)2.27579839
62Pulmonary infiltrates (HP:0002113)2.25847472
63Recurrent skin infections (HP:0001581)2.23907445
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21354814
65Recurrent fungal infections (HP:0002841)2.21275919
66Retrobulbar optic neuritis (HP:0100654)2.21264740
67Optic neuritis (HP:0100653)2.21264740
68Decreased circulating renin level (HP:0003351)2.20849747
69Recurrent viral infections (HP:0004429)2.19337925
70Skin ulcer (HP:0200042)2.16664523
71Neoplasm of the lung (HP:0100526)2.15177962
72Keratoconjunctivitis sicca (HP:0001097)2.12354103
73Bronchitis (HP:0012387)2.07093386
74Erythema (HP:0010783)2.07041427
75Abnormality of secondary sexual hair (HP:0009888)2.06640410
76Abnormality of the axillary hair (HP:0100134)2.06640410
77Nasal polyposis (HP:0100582)2.03795503
78Hypermelanotic macule (HP:0001034)2.03391064
79Autoimmune hemolytic anemia (HP:0001890)2.03158214
80Ankyloglossia (HP:0010296)2.00785953
81Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99314720
82Onycholysis (HP:0001806)1.98170750
83Abnormality of T cell number (HP:0011839)1.96164244
84Pili torti (HP:0003777)1.95009356
85Fragile skin (HP:0001030)1.94454076
86Flat acetabular roof (HP:0003180)1.93953925
87Gangrene (HP:0100758)1.93517381
88Periodontitis (HP:0000704)1.90722427
89Metaphyseal cupping (HP:0003021)1.90427405
90Increased IgM level (HP:0003496)1.89971295
91Purpura (HP:0000979)1.89721698
92Hemorrhage of the eye (HP:0011885)1.88970528
93Keratoconjunctivitis (HP:0001096)1.87819358
94Autoimmune thrombocytopenia (HP:0001973)1.87154955
95Recurrent sinusitis (HP:0011108)1.86909456
96Blepharitis (HP:0000498)1.86805093
97Chronic mucocutaneous candidiasis (HP:0002728)1.85361104
98Recurrent cutaneous fungal infections (HP:0011370)1.85361104
99Atrophic scars (HP:0001075)1.85018401
100Hematochezia (HP:0002573)1.84393888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.63411520
2TYK23.42161923
3MAP4K13.20524676
4FGFR43.02019821
5RIPK42.73191072
6MST1R2.71255484
7PRPF4B2.70356203
8RIPK12.68467915
9EPHA32.58354214
10BLK2.50199143
11EPHB12.22591097
12JAK12.21526867
13KIT1.92650237
14MAP3K141.90927547
15CDC42BPA1.90813378
16JAK31.88406300
17FGFR31.87363976
18GRK61.79691446
19IKBKE1.77354218
20CSK1.72020929
21ZAP701.63447545
22TXK1.62776470
23TBK11.61832550
24IRAK41.59139572
25FES1.52208011
26JAK21.31115886
27MAP3K11.28318960
28PDGFRA1.25253978
29EPHA21.24738130
30TGFBR11.24643605
31PIK3CA1.23664498
32SIK31.22462421
33FER1.19404796
34IRAK11.15614438
35SYK1.13662450
36LYN1.13479950
37ACVR1B1.06555153
38MATK1.05116006
39STK241.04872321
40MAP3K131.01817583
41NLK1.00673937
42BTK1.00187794
43TRIB30.99833905
44MAP3K30.96004202
45TGFBR20.95354413
46DDR20.95115628
47CSF1R0.94941635
48PRKG20.92564526
49TAOK10.91907296
50HCK0.91202996
51SMG10.89324051
52PTK60.89114404
53IKBKB0.85464444
54MAPK70.84341836
55MET0.84140880
56PKN20.82416118
57MAP3K100.82358166
58FGR0.81625165
59YES10.80781558
60BMPR20.79467293
61LCK0.78615747
62MAP3K60.76925543
63EPHB20.76410313
64RET0.68970819
65HIPK20.67179968
66IRAK30.63479013
67PDPK10.63265041
68MAP3K20.62516442
69MYLK0.60927573
70PDGFRB0.60858685
71ITK0.60725436
72FYN0.59277381
73LMTK20.57518532
74MAP2K30.57071432
75DMPK0.53891000
76TESK20.52486688
77MAPKAPK20.52428134
78LRRK20.50653644
79MAP2K20.50505172
80PDK10.49210677
81PAK40.48056856
82PDK20.47900666
83KSR20.46504437
84TAOK30.44054331
85MAP3K110.42757661
86MAPK110.42693751
87TNK20.40868934
88PRKD20.39149691
89CDK60.38319503
90ABL10.33991217
91PRKCD0.33409831
92GRK50.33391144
93TESK10.32903416
94IGF1R0.31942969
95TAOK20.30559946
96TEC0.30054494
97SRC0.29687257
98BMX0.28260439
99OXSR10.27657997
100MAP3K70.27282055

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.84536128
2Asthma_Homo sapiens_hsa053103.30661755
3Allograft rejection_Homo sapiens_hsa053303.14502462
4Autoimmune thyroid disease_Homo sapiens_hsa053203.02626775
5Graft-versus-host disease_Homo sapiens_hsa053322.92317915
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.81725696
7Leishmaniasis_Homo sapiens_hsa051402.52793158
8Type I diabetes mellitus_Homo sapiens_hsa049402.35820438
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21698640
10Antigen processing and presentation_Homo sapiens_hsa046122.11588259
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96439918
12Viral myocarditis_Homo sapiens_hsa054161.86598669
13Primary immunodeficiency_Homo sapiens_hsa053401.79007571
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.76535769
15Pertussis_Homo sapiens_hsa051331.71157672
16Osteoclast differentiation_Homo sapiens_hsa043801.66012942
17Toxoplasmosis_Homo sapiens_hsa051451.63754819
18Influenza A_Homo sapiens_hsa051641.45950799
19Tuberculosis_Homo sapiens_hsa051521.45850069
20Hematopoietic cell lineage_Homo sapiens_hsa046401.44852936
21Rheumatoid arthritis_Homo sapiens_hsa053231.34417750
22B cell receptor signaling pathway_Homo sapiens_hsa046621.32166670
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.26516669
24Other glycan degradation_Homo sapiens_hsa005111.24172624
25Complement and coagulation cascades_Homo sapiens_hsa046101.24015730
26Malaria_Homo sapiens_hsa051441.20152522
27Herpes simplex infection_Homo sapiens_hsa051681.16799217
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16468989
29TNF signaling pathway_Homo sapiens_hsa046681.16457427
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15458404
31Chemokine signaling pathway_Homo sapiens_hsa040621.13694060
32Renin-angiotensin system_Homo sapiens_hsa046141.12471191
33Phagosome_Homo sapiens_hsa041451.09126980
34Hepatitis C_Homo sapiens_hsa051601.07787216
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.07099451
36Sulfur metabolism_Homo sapiens_hsa009201.06741596
37Measles_Homo sapiens_hsa051621.06117608
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03601947
39Arginine biosynthesis_Homo sapiens_hsa002201.02298359
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01253605
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97575225
42Fat digestion and absorption_Homo sapiens_hsa049750.93374865
43Protein digestion and absorption_Homo sapiens_hsa049740.92606619
44African trypanosomiasis_Homo sapiens_hsa051430.89051906
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.86845324
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86827204
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83571718
48Amoebiasis_Homo sapiens_hsa051460.81713862
49Mineral absorption_Homo sapiens_hsa049780.80048162
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79242667
51Acute myeloid leukemia_Homo sapiens_hsa052210.79171176
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78883113
53Arachidonic acid metabolism_Homo sapiens_hsa005900.78477973
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77517466
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75283309
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73622468
57Histidine metabolism_Homo sapiens_hsa003400.73555131
58Fructose and mannose metabolism_Homo sapiens_hsa000510.72287709
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71895329
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.71748618
61Pancreatic secretion_Homo sapiens_hsa049720.68816238
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67755330
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64520871
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63626651
65Starch and sucrose metabolism_Homo sapiens_hsa005000.63318053
66T cell receptor signaling pathway_Homo sapiens_hsa046600.62660920
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62405593
68Caffeine metabolism_Homo sapiens_hsa002320.60735307
69Linoleic acid metabolism_Homo sapiens_hsa005910.60581656
70Nitrogen metabolism_Homo sapiens_hsa009100.60082051
71Apoptosis_Homo sapiens_hsa042100.57158801
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55225755
73Platelet activation_Homo sapiens_hsa046110.55112733
74Salmonella infection_Homo sapiens_hsa051320.53281429
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52677033
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51901918
77Pancreatic cancer_Homo sapiens_hsa052120.50113674
78Retinol metabolism_Homo sapiens_hsa008300.49893773
79Hepatitis B_Homo sapiens_hsa051610.48141316
80Lysosome_Homo sapiens_hsa041420.47970766
81Legionellosis_Homo sapiens_hsa051340.46789944
82Prolactin signaling pathway_Homo sapiens_hsa049170.46387177
83GnRH signaling pathway_Homo sapiens_hsa049120.43318528
84Prion diseases_Homo sapiens_hsa050200.43225824
85Galactose metabolism_Homo sapiens_hsa000520.42874964
86VEGF signaling pathway_Homo sapiens_hsa043700.42144030
87PPAR signaling pathway_Homo sapiens_hsa033200.41275779
88Systemic lupus erythematosus_Homo sapiens_hsa053220.40713109
89Ether lipid metabolism_Homo sapiens_hsa005650.40189080
90HTLV-I infection_Homo sapiens_hsa051660.38743195
91Shigellosis_Homo sapiens_hsa051310.38549494
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.37450026
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.35321978
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33038941
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31825113
96HIF-1 signaling pathway_Homo sapiens_hsa040660.31565335
97Renal cell carcinoma_Homo sapiens_hsa052110.31069193
98Chronic myeloid leukemia_Homo sapiens_hsa052200.30500330
99Endocytosis_Homo sapiens_hsa041440.29844019
100Epstein-Barr virus infection_Homo sapiens_hsa051690.29287140

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