IGHV1-69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00029.39256685
2Fc-gamma receptor signaling pathway (GO:0038094)9.39256685
3Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)9.39256685
4Fc receptor mediated stimulatory signaling pathway (GO:0002431)9.27997894
5retina homeostasis (GO:0001895)8.47029723
6humoral immune response (GO:0006959)7.85161271
7positive regulation of respiratory burst (GO:0060267)6.47420118
8negative regulation of B cell proliferation (GO:0030889)6.45368729
9glomerular filtration (GO:0003094)6.40606149
10antigen processing and presentation of endogenous antigen (GO:0019883)6.30186828
11positive regulation of B cell differentiation (GO:0045579)6.17180675
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.01248297
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.01248297
14negative regulation of glucose import (GO:0046325)5.93341066
15renal filtration (GO:0097205)5.84947265
16positive regulation of Rho protein signal transduction (GO:0035025)5.82677495
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.82362121
18B cell receptor signaling pathway (GO:0050853)5.69266068
19immune response-activating cell surface receptor signaling pathway (GO:0002429)5.53493134
20L-fucose metabolic process (GO:0042354)5.47935532
21L-fucose catabolic process (GO:0042355)5.47935532
22fucose catabolic process (GO:0019317)5.47935532
23regulation of B cell differentiation (GO:0045577)5.24810346
24regulation of glucose import in response to insulin stimulus (GO:2001273)5.14793142
25negative regulation of glucose transport (GO:0010829)4.86624935
26regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.67546410
27regulation of B cell proliferation (GO:0030888)4.65145493
28signal peptide processing (GO:0006465)4.56944643
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.51058164
30cellular response to zinc ion (GO:0071294)4.43748537
31regulation of respiratory burst (GO:0060263)4.19575832
32positive regulation of gamma-delta T cell activation (GO:0046645)4.16340227
33positive regulation of Rap GTPase activity (GO:0032854)4.09469155
34antibacterial humoral response (GO:0019731)3.95144490
35phenylpropanoid metabolic process (GO:0009698)3.92064781
36germinal center formation (GO:0002467)3.88837919
37Fc receptor signaling pathway (GO:0038093)3.85163249
38antimicrobial humoral response (GO:0019730)3.83122981
39activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.79151007
40regulation of B cell receptor signaling pathway (GO:0050855)3.75122772
41regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.75082518
42maternal placenta development (GO:0001893)3.74905283
43bone resorption (GO:0045453)3.74481182
44immune response-activating signal transduction (GO:0002757)3.71613545
45positive regulation of nuclease activity (GO:0032075)3.70801814
46regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.70660960
47immunoglobulin mediated immune response (GO:0016064)3.70656624
48immune response-regulating cell surface receptor signaling pathway (GO:0002768)3.69560572
49negative regulation of osteoclast differentiation (GO:0045671)3.68406128
50Fc-epsilon receptor signaling pathway (GO:0038095)3.67362269
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64360944
52interferon-gamma-mediated signaling pathway (GO:0060333)3.63344422
53intestinal epithelial cell development (GO:0060576)3.62530228
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.59890553
55protein N-linked glycosylation via asparagine (GO:0018279)3.58722208
56peptidyl-asparagine modification (GO:0018196)3.55600593
57mature B cell differentiation (GO:0002335)3.54998924
58endoplasmic reticulum unfolded protein response (GO:0030968)3.54351539
59negative regulation of cell killing (GO:0031342)3.54283712
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54283712
61regulation of nuclease activity (GO:0032069)3.51451111
62regulation of Rap GTPase activity (GO:0032317)3.51280312
63surfactant homeostasis (GO:0043129)3.49355254
64N-acetylneuraminate metabolic process (GO:0006054)3.45481368
65cellular response to type I interferon (GO:0071357)3.42636794
66type I interferon signaling pathway (GO:0060337)3.42636794
67cellular response to unfolded protein (GO:0034620)3.40917693
68response to type I interferon (GO:0034340)3.39962201
69mannose metabolic process (GO:0006013)3.35981617
70activation of immune response (GO:0002253)3.34820721
71detection of other organism (GO:0098543)3.33195649
72protein N-linked glycosylation (GO:0006487)3.32189968
73detection of bacterium (GO:0016045)3.29682001
74sequestering of metal ion (GO:0051238)3.25686232
75positive regulation of immunoglobulin production (GO:0002639)3.24902194
76negative regulation of B cell activation (GO:0050869)3.23596598
77epithelial cell differentiation involved in prostate gland development (GO:0060742)3.20623631
78regulation of B cell activation (GO:0050864)3.19503731
79B cell proliferation (GO:0042100)3.19371881
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18039522
81ER-nucleus signaling pathway (GO:0006984)3.16226129
82regulation of gamma-delta T cell differentiation (GO:0045586)3.13511529
83COPI coating of Golgi vesicle (GO:0048205)3.11218963
84Golgi transport vesicle coating (GO:0048200)3.11218963
85regulation of interferon-beta biosynthetic process (GO:0045357)3.08712561
86cellular response to topologically incorrect protein (GO:0035967)3.07728106
87respiratory burst (GO:0045730)3.06990984
88defense response to Gram-negative bacterium (GO:0050829)3.05226441
89response to endoplasmic reticulum stress (GO:0034976)3.02248954
90complement activation, classical pathway (GO:0006958)20.6546599
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93458255
92regulation of antigen processing and presentation (GO:0002577)2.92567506
93UDP-N-acetylglucosamine metabolic process (GO:0006047)2.91892268
94proline biosynthetic process (GO:0006561)2.91361294
95cellular response to interferon-gamma (GO:0071346)2.89953801
96apoptotic cell clearance (GO:0043277)2.87485201
97regulation of cellular extravasation (GO:0002691)2.87425536
98regulation of gamma-delta T cell activation (GO:0046643)2.85385086
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85106908
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84945385
101leukocyte aggregation (GO:0070486)2.84274127
102flavonoid metabolic process (GO:0009812)2.82996462
103antigen receptor-mediated signaling pathway (GO:0050851)2.80484043
104B cell homeostasis (GO:0001782)2.79580883
105fucose metabolic process (GO:0006004)2.79475396
106mature B cell differentiation involved in immune response (GO:0002313)2.78753576
107nerve growth factor signaling pathway (GO:0038180)2.78732619
108detection of external biotic stimulus (GO:0098581)2.78429813
109neutrophil activation (GO:0042119)2.77620923
110negative thymic T cell selection (GO:0045060)2.77564869
111B cell mediated immunity (GO:0019724)2.77129085
112serine transport (GO:0032329)2.73509274
113N-glycan processing (GO:0006491)2.72455923
114fucosylation (GO:0036065)2.71963545
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71948313
116negative regulation of cellular response to insulin stimulus (GO:1900077)2.71049756
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.70865537
118modulation by symbiont of host immune response (GO:0052553)2.70865537
119positive regulation by symbiont of host defense response (GO:0052509)2.70865537
120modulation by symbiont of host defense response (GO:0052031)2.70865537
121modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70865537
122modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70865537
123response to interferon-gamma (GO:0034341)2.69568971
124positive thymic T cell selection (GO:0045059)2.68480193
125positive regulation of B cell activation (GO:0050871)2.65941932
126regulation of water loss via skin (GO:0033561)2.65287708
127chronic inflammatory response (GO:0002544)2.64117994
128wound healing, spreading of epidermal cells (GO:0035313)2.64049457
129regulation of superoxide anion generation (GO:0032928)2.63974206
130production of molecular mediator involved in inflammatory response (GO:0002532)2.63052732
131cellular extravasation (GO:0045123)2.62215883
132tissue homeostasis (GO:0001894)2.62145131
133response to unfolded protein (GO:0006986)2.59220590
134T-helper 1 type immune response (GO:0042088)2.58427711
135establishment of skin barrier (GO:0061436)2.56215804
136regulation of integrin activation (GO:0033623)2.55415923
137regulation of T cell tolerance induction (GO:0002664)2.55295487
138macrophage activation involved in immune response (GO:0002281)2.55231284
139interferon-gamma secretion (GO:0072643)2.55170798
140positive regulation of histone deacetylation (GO:0031065)2.54747379
141ER overload response (GO:0006983)2.51208567
142negative regulation of humoral immune response (GO:0002921)2.51124446
143regulation of B cell apoptotic process (GO:0002902)2.50948070
144negative T cell selection (GO:0043383)2.49944505
145L-serine transport (GO:0015825)2.48817856
146negative regulation of complement activation (GO:0045916)2.47193155
147positive regulation of antigen processing and presentation (GO:0002579)2.44294075
148myeloid dendritic cell differentiation (GO:0043011)2.43620975
149establishment of planar polarity (GO:0001736)2.42054437
150establishment of tissue polarity (GO:0007164)2.42054437
151negative regulation of interleukin-12 production (GO:0032695)2.41657811
152defense response to protozoan (GO:0042832)2.41454743
153positive regulation of type 2 immune response (GO:0002830)2.40687230
154regulation of regulatory T cell differentiation (GO:0045589)2.40495583
155detection of biotic stimulus (GO:0009595)2.39626538
156response to interleukin-15 (GO:0070672)2.39320034
157regulation of necroptotic process (GO:0060544)2.38637553
158dendritic cell chemotaxis (GO:0002407)2.38197342
159cellular glucuronidation (GO:0052695)2.34741290
160negative regulation of erythrocyte differentiation (GO:0045647)2.34235872
161detection of molecule of bacterial origin (GO:0032490)2.34091007
162regulation of necrotic cell death (GO:0010939)2.31861229
163regulation of macrophage chemotaxis (GO:0010758)2.31772025
164NIK/NF-kappaB signaling (GO:0038061)2.30570867
165daunorubicin metabolic process (GO:0044597)2.29968352
166polyketide metabolic process (GO:0030638)2.29968352
167doxorubicin metabolic process (GO:0044598)2.29968352
168adhesion of symbiont to host cell (GO:0044650)2.29927394
169virion attachment to host cell (GO:0019062)2.29927394
170chemical homeostasis within a tissue (GO:0048875)2.29462331
171protein-chromophore linkage (GO:0018298)2.28086666
172complement activation (GO:0006956)15.8642901
173protein activation cascade (GO:0072376)10.2551394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.50066061
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.70848297
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.21087889
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.98916171
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.50853304
6MYC_22102868_ChIP-Seq_BL_Human4.32458673
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.24323866
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93028242
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.76151724
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.69843665
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.57453522
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.45012441
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31841949
14IRF8_27001747_Chip-Seq_BMDM_Mouse3.08026358
15VDR_21846776_ChIP-Seq_THP-1_Human3.07973983
16RUNX_20019798_ChIP-Seq_JUKART_Human2.85768913
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76761941
18MAF_26560356_Chip-Seq_TH1_Human2.70676078
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67868448
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54882150
21MYB_26560356_Chip-Seq_TH1_Human2.46643262
22MYB_26560356_Chip-Seq_TH2_Human2.42017367
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30801940
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27937490
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27793054
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25471606
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23392976
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20558392
29GATA1_22025678_ChIP-Seq_K562_Human2.16565566
30TRIM28_21343339_ChIP-Seq_HEK293_Human2.14739145
31UTX_26944678_Chip-Seq_JUKART_Human2.12654420
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09950918
33VDR_24763502_ChIP-Seq_THP-1_Human2.09548896
34TCF7_22412390_ChIP-Seq_EML_Mouse2.04672557
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04398770
36MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04051549
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03154631
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00946804
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90285925
40CLOCK_20551151_ChIP-Seq_293T_Human1.84962807
41KDM2B_26808549_Chip-Seq_DND41_Human1.79910734
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78955989
43SPI1_23547873_ChIP-Seq_NB4_Human1.77225500
44GATA3_27048872_Chip-Seq_THYMUS_Human1.76541606
45E2F7_22180533_ChIP-Seq_HELA_Human1.75181276
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66263857
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62779175
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.61633247
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61444286
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59944143
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57974409
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57248223
53PU.1_20513432_ChIP-Seq_Bcells_Mouse1.52717039
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50913061
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50515958
56SPI1_23127762_ChIP-Seq_K562_Human1.50105183
57SCL_19346495_ChIP-Seq_HPC-7_Human1.49908946
58MAF_26560356_Chip-Seq_TH2_Human1.48225737
59GATA3_26560356_Chip-Seq_TH2_Human1.47069012
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44236992
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40904344
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37130409
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.36245661
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33869411
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30522209
66* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29652841
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26348321
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23599857
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22897278
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.22486619
71LXR_22292898_ChIP-Seq_THP-1_Human1.21175580
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20850045
73PU_27001747_Chip-Seq_BMDM_Mouse1.18638508
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18310243
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17441211
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.15926344
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14920219
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14661786
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12104919
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10960940
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.10673246
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07626657
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07424866
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07241867
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06271339
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06206762
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05588817
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05588817
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05144585
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03031768
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02510270
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02484703
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01182737
94GATA1_19941826_ChIP-Seq_K562_Human1.00459682
95GATA2_19941826_ChIP-Seq_K562_Human1.00065127
96RXR_22158963_ChIP-Seq_LIVER_Mouse0.99106751
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.95978017
98SOX2_20726797_ChIP-Seq_SW620_Human0.95445718
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.94319117
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94206338
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.91531028
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91233380
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.90426786
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88612494
105STAT1_20625510_ChIP-Seq_HELA_Human0.88338319
106GATA3_26560356_Chip-Seq_TH1_Human0.88285431
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87325138
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.86863975
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86620443
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.86185387
111RACK7_27058665_Chip-Seq_MCF-7_Human0.86140064
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.85682420
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.85682420
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.85612173
115FOXM1_23109430_ChIP-Seq_U2OS_Human0.85010307
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84260679
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83731165
118NCOR1_26117541_ChIP-Seq_K562_Human0.83541757
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83496184
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82559740
121SMRT_27268052_Chip-Seq_Bcells_Human0.82413232
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82202570
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81610447
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81345135
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78692243
126RXR_22108803_ChIP-Seq_LS180_Human0.78049216
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76979930
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76874056
129SPI1_20517297_ChIP-Seq_HL60_Human0.76162531
130EGR1_19032775_ChIP-ChIP_M12_Human0.75513222
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74384929
132ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73866999
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73832721
134VDR_24787735_ChIP-Seq_THP-1_Human0.73784794
135KDM2B_26808549_Chip-Seq_K562_Human0.73398853
136RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72779557
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72351157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.75539504
2MP0001835_abnormal_antigen_presentation5.08691591
3MP0003724_increased_susceptibility_to5.00744783
4MP0001800_abnormal_humoral_immune4.60366328
5MP0001790_abnormal_immune_system3.70369323
6MP0005387_immune_system_phenotype3.70369323
7MP0002452_abnormal_antigen_presenting3.44665981
8MP0005275_abnormal_skin_tensile3.22396657
9MP0005671_abnormal_response_to3.00817400
10MP0002723_abnormal_immune_serum2.85030456
11MP0003436_decreased_susceptibility_to2.79605972
12MP0002420_abnormal_adaptive_immunity2.78414373
13MP0005000_abnormal_immune_tolerance2.76498525
14MP0001819_abnormal_immune_cell2.72965833
15MP0003300_gastrointestinal_ulcer2.59767323
16MP0002398_abnormal_bone_marrow2.57281730
17MP0000716_abnormal_immune_system2.53357664
18MP0000685_abnormal_immune_system2.49147335
19MP0001879_abnormal_lymphatic_vessel2.38935648
20MP0004264_abnormal_extraembryonic_tissu2.31652070
21MP0005503_abnormal_tendon_morphology2.23599435
22MP0005025_abnormal_response_to2.22300129
23MP0000689_abnormal_spleen_morphology2.19604937
24MP0008438_abnormal_cutaneous_collagen2.14819752
25MP0010234_abnormal_vibrissa_follicle2.13652298
26MP0002429_abnormal_blood_cell2.05623504
27MP0002419_abnormal_innate_immunity2.03543832
28MP0002166_altered_tumor_susceptibility2.02896659
29MP0002148_abnormal_hypersensitivity_rea2.02576799
30MP0000579_abnormal_nail_morphology1.97459108
31MP0001845_abnormal_inflammatory_respons1.85449197
32MP0009333_abnormal_splenocyte_physiolog1.78168827
33MP0002722_abnormal_immune_system1.77901536
34MP0010155_abnormal_intestine_physiology1.76248260
35MP0004947_skin_inflammation1.67143370
36MP0005166_decreased_susceptibility_to1.66698711
37MP0003448_altered_tumor_morphology1.60254944
38MP0009785_altered_susceptibility_to1.58505562
39MP0002006_tumorigenesis1.55249046
40MP0000858_altered_metastatic_potential1.54526084
41MP0006054_spinal_hemorrhage1.52614563
42MP0003279_aneurysm1.51748525
43MP0004782_abnormal_surfactant_physiolog1.50005919
44MP0001873_stomach_inflammation1.47607342
45MP0003763_abnormal_thymus_physiology1.46333664
46MP0004510_myositis1.45125436
47MP0000465_gastrointestinal_hemorrhage1.44261169
48MP0003828_pulmonary_edema1.44100466
49MP0002405_respiratory_system_inflammati1.42736020
50MP0000383_abnormal_hair_follicle1.41532970
51MP0002396_abnormal_hematopoietic_system1.39674375
52MP0001851_eye_inflammation1.39294377
53MP0000343_altered_response_to1.38162750
54MP0001853_heart_inflammation1.35269163
55MP0003045_fibrosis1.34022347
56MP0002933_joint_inflammation1.33393859
57MP0010678_abnormal_skin_adnexa1.31661936
58MP0005164_abnormal_response_to1.31020055
59MP0008004_abnormal_stomach_pH1.29862089
60MP0005390_skeleton_phenotype1.29249979
61MP0000681_abnormal_thyroid_gland1.24973763
62MP0002138_abnormal_hepatobiliary_system1.24968151
63MP0002877_abnormal_melanocyte_morpholog1.20368297
64MP0003453_abnormal_keratinocyte_physiol1.19956830
65MP0003183_abnormal_peptide_metabolism1.18097604
66MP0008872_abnormal_physiological_respon1.17719935
67MP0005310_abnormal_salivary_gland1.16288415
68MP0001533_abnormal_skeleton_physiology1.15233125
69MP0008569_lethality_at_weaning1.12753091
70MP0000703_abnormal_thymus_morphology1.12170075
71MP0008260_abnormal_autophagy1.11320383
72MP0005360_urolithiasis1.10500567
73MP0000920_abnormal_myelination1.09631268
74MP0003866_abnormal_defecation1.08705749
75MP0005464_abnormal_platelet_physiology1.08541523
76MP0004808_abnormal_hematopoietic_stem1.06630455
77MP0002019_abnormal_tumor_incidence1.05812768
78MP0005257_abnormal_intraocular_pressure1.02023899
79MP0001663_abnormal_digestive_system1.01727589
80MP0002254_reproductive_system_inflammat1.00726525
81MP0006082_CNS_inflammation1.00186590
82MP0003075_altered_response_to0.99998949
83MP0009764_decreased_sensitivity_to0.99322855
84MP0005076_abnormal_cell_differentiation0.99032160
85MP0009046_muscle_twitch0.98879198
86MP0001958_emphysema0.98591518
87MP0010368_abnormal_lymphatic_system0.98076788
88MP0002139_abnormal_hepatobiliary_system0.97922847
89MP0004858_abnormal_nervous_system0.96847520
90MP0003656_abnormal_erythrocyte_physiolo0.95750261
91MP0000249_abnormal_blood_vessel0.93014510
92MP0004883_abnormal_blood_vessel0.92539433
93MP0002136_abnormal_kidney_physiology0.91572833
94MP0002796_impaired_skin_barrier0.90933804
95MP0000490_abnormal_crypts_of0.89964326
96MP0001216_abnormal_epidermal_layer0.88312108
97MP0002693_abnormal_pancreas_physiology0.87415652
98MP0009278_abnormal_bone_marrow0.86598381
99MP0008469_abnormal_protein_level0.86299517
100MP0002168_other_aberrant_phenotype0.86209478
101MP0000604_amyloidosis0.85833892
102MP0002998_abnormal_bone_remodeling0.85459631
103MP0002060_abnormal_skin_morphology0.85220419
104MP0008961_abnormal_basal_metabolism0.83307989
105MP0010352_gastrointestinal_tract_polyps0.83215567
106MP0003795_abnormal_bone_structure0.81535649
107MP0001919_abnormal_reproductive_system0.80627729
108MP0003566_abnormal_cell_adhesion0.80319241
109MP0009840_abnormal_foam_cell0.80305778
110MP0000003_abnormal_adipose_tissue0.79670386
111MP0000733_abnormal_muscle_development0.79481416
112MP0003705_abnormal_hypodermis_morpholog0.77691255
113MP0000609_abnormal_liver_physiology0.76793988
114MP0001944_abnormal_pancreas_morphology0.74329590
115MP0001666_abnormal_nutrient_absorption0.74025601
116MP0002277_abnormal_respiratory_mucosa0.73597797
117MP0000678_abnormal_parathyroid_gland0.71941222
118MP0003091_abnormal_cell_migration0.71096384
119MP0009765_abnormal_xenobiotic_induced0.70626263
120MP0005058_abnormal_lysosome_morphology0.70501095
121MP0002133_abnormal_respiratory_system0.69284573
122MP0005388_respiratory_system_phenotype0.69284573
123MP0008874_decreased_physiological_sensi0.67412058
124MP0003172_abnormal_lysosome_physiology0.66449474
125MP0005397_hematopoietic_system_phenotyp0.64773931
126MP0001545_abnormal_hematopoietic_system0.64773931
127MP0001881_abnormal_mammary_gland0.62594860
128MP0002083_premature_death0.61346999
129MP0008873_increased_physiological_sensi0.61342889
130MP0001191_abnormal_skin_condition0.61316670
131MP0005381_digestive/alimentary_phenotyp0.61179189
132MP0004134_abnormal_chest_morphology0.59813598
133MP0005023_abnormal_wound_healing0.59567999
134MP0003186_abnormal_redox_activity0.59503418
135MP0000477_abnormal_intestine_morphology0.59251236
136MP0003690_abnormal_glial_cell0.59007830
137MP0003191_abnormal_cellular_cholesterol0.58790949
138MP0004859_abnormal_synaptic_plasticity0.58428790
139MP0009643_abnormal_urine_homeostasis0.54742718
140MP0009763_increased_sensitivity_to0.54582436

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.21724175
2Abnormality of B cell number (HP:0010975)8.96590532
3B lymphocytopenia (HP:0010976)8.96590532
4Prostate neoplasm (HP:0100787)8.80459776
5Colitis (HP:0002583)7.52911992
6Recurrent sinusitis (HP:0011108)6.98867519
7Cellulitis (HP:0100658)6.73670816
8Systemic lupus erythematosus (HP:0002725)6.26683451
9Recurrent bronchitis (HP:0002837)6.16699351
10Verrucae (HP:0200043)5.94775814
11Papilloma (HP:0012740)5.94775814
12Recurrent viral infections (HP:0004429)5.79809395
13Inflammation of the large intestine (HP:0002037)5.70223176
14Abnormality of the prostate (HP:0008775)5.60675589
15Gastrointestinal inflammation (HP:0004386)5.49478377
16IgM deficiency (HP:0002850)5.41091711
17Gastrointestinal stroma tumor (HP:0100723)5.25227644
18Meningitis (HP:0001287)4.91459021
19Recurrent pneumonia (HP:0006532)4.77266423
20Chronic otitis media (HP:0000389)4.37274311
21Abnormality of complement system (HP:0005339)4.12631527
22Alopecia of scalp (HP:0002293)4.06350067
23Osteomyelitis (HP:0002754)4.05437126
24Complement deficiency (HP:0004431)3.86946563
25Recurrent lower respiratory tract infections (HP:0002783)3.84172874
26Glomerulonephritis (HP:0000099)3.83139194
27Chronic sinusitis (HP:0011109)3.76294885
28Thick nail (HP:0001805)3.74055277
29Emphysema (HP:0002097)3.68678680
30Recurrent otitis media (HP:0000403)3.68430375
31Leukocytosis (HP:0001974)3.66401618
32Bronchitis (HP:0012387)3.46186754
33Abnormal hair laboratory examination (HP:0003328)3.45318478
34Sepsis (HP:0100806)3.41540957
35Abnormality of male internal genitalia (HP:0000022)3.32530108
36Panhypogammaglobulinemia (HP:0003139)3.30818998
37Recurrent fungal infections (HP:0002841)3.16306331
38Thyroiditis (HP:0100646)3.11888167
39Skin rash (HP:0000988)3.07607832
40IgA deficiency (HP:0002720)3.06134180
41Restrictive lung disease (HP:0002091)3.05529587
42Vasculitis (HP:0002633)3.04639546
43Xerostomia (HP:0000217)3.02425108
44Nephritis (HP:0000123)3.00221770
45Recurrent abscess formation (HP:0002722)2.99432105
46Abnormality of T cell physiology (HP:0011840)2.91231660
47Pili torti (HP:0003777)2.90280816
48Follicular hyperkeratosis (HP:0007502)2.89942344
49Interstitial pulmonary disease (HP:0006530)2.86069436
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.85181833
51Lymphopenia (HP:0001888)2.82862509
52Orchitis (HP:0100796)2.82178893
53Neoplasm of the lung (HP:0100526)2.79198467
54Small epiphyses (HP:0010585)2.78471923
55IgG deficiency (HP:0004315)2.77751456
56Abnormality of secondary sexual hair (HP:0009888)2.75349004
57Abnormality of the axillary hair (HP:0100134)2.75349004
58Recurrent bacterial skin infections (HP:0005406)2.75157702
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.68412566
60Malnutrition (HP:0004395)2.67896281
61Eczematoid dermatitis (HP:0000976)2.61269427
62Nasal polyposis (HP:0100582)2.56428482
63Gastrointestinal infarctions (HP:0005244)2.51033189
64Premature loss of primary teeth (HP:0006323)2.50104559
65Recurrent skin infections (HP:0001581)2.49506803
66Metaphyseal cupping (HP:0003021)2.47359335
67Increased IgE level (HP:0003212)2.47076506
68Abnormality of T cells (HP:0002843)2.46023262
69Recurrent gram-negative bacterial infections (HP:0005420)2.39837590
70Neoplasm of the respiratory system (HP:0100606)2.39373286
71Hypermelanotic macule (HP:0001034)2.39330911
72Skin ulcer (HP:0200042)2.31859351
73Mediastinal lymphadenopathy (HP:0100721)2.29992557
74Mitral stenosis (HP:0001718)2.27571969
75Bronchiectasis (HP:0002110)2.23983362
76Hemoptysis (HP:0002105)2.19822929
77Peritonitis (HP:0002586)2.19767254
78Optic neuritis (HP:0100653)2.16864173
79Retrobulbar optic neuritis (HP:0100654)2.16864173
80Neutropenia (HP:0001875)2.16075690
81Recurrent cutaneous fungal infections (HP:0011370)2.14455684
82Chronic mucocutaneous candidiasis (HP:0002728)2.14455684
83Abnormality of the nasal mucosa (HP:0000433)2.14270920
84Vacuolated lymphocytes (HP:0001922)2.13847308
85Hypoplastic labia majora (HP:0000059)2.10160690
86Abnormality of the salivary glands (HP:0010286)2.07758336
87T lymphocytopenia (HP:0005403)2.07745719
88Abnormality of T cell number (HP:0011839)2.06963646
89Abnormality of the peritoneum (HP:0002585)2.05893193
90Atrophic scars (HP:0001075)2.04451846
91Pulmonary infiltrates (HP:0002113)2.02826038
92Right ventricular cardiomyopathy (HP:0011663)2.01052435
93Depressed nasal tip (HP:0000437)1.99852878
94Blepharitis (HP:0000498)1.99787248
95Obstructive lung disease (HP:0006536)1.99273988
96Chronic obstructive pulmonary disease (HP:0006510)1.99273988
97Purpura (HP:0000979)1.95817359
98Segmental peripheral demyelination/remyelination (HP:0003481)1.94919953
99Cerebral aneurysm (HP:0004944)1.94132362
100Ankyloglossia (HP:0010296)1.93946074
101Breast hypoplasia (HP:0003187)1.93633426
102Abnormal foot bone ossification (HP:0010675)1.92644645
103Selective tooth agenesis (HP:0001592)1.92285291
104Fragile skin (HP:0001030)1.91665743
105Hematochezia (HP:0002573)1.91466080
106Abnormality of the labia majora (HP:0012881)1.88584877
107Bladder diverticulum (HP:0000015)1.88074965
108Keratoconjunctivitis sicca (HP:0001097)1.87607502
109Osteolytic defects of the hand bones (HP:0009699)1.86659378
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.86659378
111Chronic diarrhea (HP:0002028)1.86042532
112Split foot (HP:0001839)1.85766027
113Erythema (HP:0010783)1.82959567
114Abnormality of nail color (HP:0100643)1.82955742
115Autoimmune hemolytic anemia (HP:0001890)1.82653682
116Oligodontia (HP:0000677)1.80211003
117Flattened epiphyses (HP:0003071)1.79492547
118Viral hepatitis (HP:0006562)1.77803801
119Elevated erythrocyte sedimentation rate (HP:0003565)1.75530265
120Absent eyelashes (HP:0000561)1.74955051
121Leukopenia (HP:0001882)1.72208788
122Pustule (HP:0200039)1.72052234
123Myositis (HP:0100614)1.70373758
124Arthralgia (HP:0002829)1.70330214
125Macroorchidism (HP:0000053)1.69564544
126Abnormality of the fingertips (HP:0001211)1.67880840
127Abnormal tarsal ossification (HP:0008369)1.66605746
128Abnormality of macrophages (HP:0004311)1.65243734
129Lymphoma (HP:0002665)1.65121462
130Basal cell carcinoma (HP:0002671)1.64601048
131Urticaria (HP:0001025)1.64445349
132Hypoplasia of the thymus (HP:0000778)1.62875524
133Ulnar deviation of the wrist (HP:0003049)1.62856730
134Dehydration (HP:0001944)1.59313404
135Abnormality of the intrinsic pathway (HP:0010989)1.58959669
136Cervical subluxation (HP:0003308)1.58789022
137Thrombocytosis (HP:0001894)1.56184570
138Papilledema (HP:0001085)1.54020672
139Acrocyanosis (HP:0001063)1.53933810
140Combined immunodeficiency (HP:0005387)1.52499129
141Chest pain (HP:0100749)1.51605278
142Abnormality of the lumbar spine (HP:0100712)1.50914327
143Eosinophilia (HP:0001880)1.50119486
144Encephalitis (HP:0002383)1.49105811
145Autoimmune thrombocytopenia (HP:0001973)1.48381685
146Hypergammaglobulinemia (HP:0010702)1.47851025
147Deep venous thrombosis (HP:0002625)1.46065945
148Spontaneous hematomas (HP:0007420)1.44980756
149Mucopolysacchariduria (HP:0008155)1.44123746
150Urinary glycosaminoglycan excretion (HP:0003541)1.44123746
151Gingival bleeding (HP:0000225)1.41788250
152Gingivitis (HP:0000230)1.41510262
153Coxa valga (HP:0002673)1.40717483
154Irregular vertebral endplates (HP:0003301)1.40412582
155Myocardial infarction (HP:0001658)1.40181270
156Severe combined immunodeficiency (HP:0004430)1.39928749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.26872583
2MAP4K15.21623809
3TAOK33.90395331
4PRPF4B3.23006201
5RIPK43.20687805
6GRK63.18854961
7TYK22.85348412
8MAP3K102.83270759
9TGFBR12.78964275
10SIK22.49572365
11EIF2AK32.42746214
12SYK2.31955018
13NME22.23278422
14BLK2.10896830
15MAP3K141.99666341
16CSF1R1.98470600
17CDC42BPA1.98244055
18KIT1.92367088
19RIPK11.78095523
20JAK11.77847270
21TXK1.72531273
22BTK1.70108669
23IRAK31.64167763
24IRAK41.60364905
25MAP3K131.55478636
26MAP3K11.36027069
27MAP3K31.29763782
28HIPK21.28265565
29HCK1.28219915
30PRKCH1.27907238
31PDGFRA1.27121317
32STK241.23666557
33IRAK11.23646799
34ITK1.19824199
35STK101.16893472
36PIK3CG1.16278822
37LYN1.14857593
38TBK11.13122521
39LATS11.11338899
40FGFR41.11001072
41FES1.05591322
42MAP3K91.02321090
43IKBKE1.01818596
44JAK31.00010351
45MST1R0.99112648
46BMPR20.98058115
47LRRK20.97086780
48EPHB10.96307715
49FGFR30.95213921
50YES10.93594078
51DMPK0.91143636
52FER0.89411214
53PIM10.88614483
54ALK0.88494397
55KSR20.88453072
56TEC0.87521443
57NEK90.86853951
58NEK20.86677096
59TGFBR20.83268220
60PRKCQ0.83134338
61CSK0.77800026
62CDK120.75822016
63SIK10.75346371
64RET0.73863982
65IKBKB0.73831879
66STK38L0.73121893
67PDK10.72577387
68NLK0.72077286
69MAP3K60.71525240
70LCK0.71050813
71BMX0.70410598
72EEF2K0.70389228
73TRIB30.69297010
74MAPK70.67813971
75CLK10.66192911
76LATS20.65549630
77MAP3K20.64036252
78BCKDK0.62743498
79PKN20.61311649
80JAK20.58193420
81DDR20.56504954
82PAK40.55721421
83PDK20.53508884
84FYN0.53477096
85PRKD10.52100027
86PDGFRB0.49166761
87SMG10.49027787
88TAOK10.48035967
89TAOK20.48015781
90MAPK40.47832411
91MST40.45323770
92MAPKAPK20.45051229
93MAP3K70.44997942
94IRAK20.44142749
95UHMK10.42412995
96PKN10.41822176
97FGR0.39873277
98MYLK0.39849990
99MAPK120.38582613
100SGK30.36916862
101PRKD20.36770370
102BRSK10.36269466
103PRKCD0.36232773
104MAPK110.35123666
105PTK60.35080058
106GRK50.34457373
107PRKG20.33870465
108ABL10.33546613
109PDPK10.33384556
110TTN0.33291196
111PIK3CA0.31645861
112CDK40.30483768
113MARK30.28540998
114INSR0.28220278
115PTK2B0.27971178
116CHUK0.27357904
117EGFR0.27299549
118CDK60.27001516
119BUB10.26985614
120FRK0.26666676
121BRD40.26449410
122CSNK1G20.25970658
123EPHA30.24818403
124IGF1R0.24807179
125MAP2K30.24278413
126MATK0.24214085
127TESK10.24104003
128BRSK20.23142991
129CSNK1A1L0.22157337
130STK110.20917443
131MAP3K80.18810335
132RAF10.17504570
133WNK10.16728761
134CSNK1G30.16473026
135MAPK30.13858263
136ZAP700.13747763
137SIK30.13435125
138SRC0.13096836

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046727.90193047
2Primary immunodeficiency_Homo sapiens_hsa053405.03878669
3B cell receptor signaling pathway_Homo sapiens_hsa046624.40294978
4Protein export_Homo sapiens_hsa030603.34301723
5N-Glycan biosynthesis_Homo sapiens_hsa005103.21897271
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.20614024
7Graft-versus-host disease_Homo sapiens_hsa053322.87303289
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35983087
9Type I diabetes mellitus_Homo sapiens_hsa049402.30774516
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06405357
11Osteoclast differentiation_Homo sapiens_hsa043801.87371337
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81894745
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.78259710
14Leishmaniasis_Homo sapiens_hsa051401.66258855
15Asthma_Homo sapiens_hsa053101.65549764
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62598883
17Complement and coagulation cascades_Homo sapiens_hsa046101.60225165
18Rheumatoid arthritis_Homo sapiens_hsa053231.47871811
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41865381
20T cell receptor signaling pathway_Homo sapiens_hsa046601.41543744
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39282648
22Phagosome_Homo sapiens_hsa041451.35270136
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34264866
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31668844
25Antigen processing and presentation_Homo sapiens_hsa046121.29639888
26Chemokine signaling pathway_Homo sapiens_hsa040621.27216979
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25128235
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.13203175
29Staphylococcus aureus infection_Homo sapiens_hsa051501.13075179
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10668883
31Tuberculosis_Homo sapiens_hsa051521.09477552
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09124134
33Long-term potentiation_Homo sapiens_hsa047201.04616189
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03370482
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02872473
36Neurotrophin signaling pathway_Homo sapiens_hsa047220.97178995
37Other glycan degradation_Homo sapiens_hsa005110.93951880
38Hematopoietic cell lineage_Homo sapiens_hsa046400.93643621
39Non-small cell lung cancer_Homo sapiens_hsa052230.92283202
40Measles_Homo sapiens_hsa051620.91802832
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.89922824
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89439536
43Amoebiasis_Homo sapiens_hsa051460.83626806
44Hepatitis B_Homo sapiens_hsa051610.81055245
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79721008
46Malaria_Homo sapiens_hsa051440.79549977
47VEGF signaling pathway_Homo sapiens_hsa043700.74540723
48Insulin resistance_Homo sapiens_hsa049310.73389927
49Prion diseases_Homo sapiens_hsa050200.72793105
50Type II diabetes mellitus_Homo sapiens_hsa049300.72266212
51Acute myeloid leukemia_Homo sapiens_hsa052210.70997873
52Thyroid hormone synthesis_Homo sapiens_hsa049180.70157486
53Pertussis_Homo sapiens_hsa051330.70152517
54Amphetamine addiction_Homo sapiens_hsa050310.67691735
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67665225
56Toxoplasmosis_Homo sapiens_hsa051450.64287710
57Platelet activation_Homo sapiens_hsa046110.64115064
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.63199164
59Apoptosis_Homo sapiens_hsa042100.63146690
60Protein digestion and absorption_Homo sapiens_hsa049740.62800372
61Viral myocarditis_Homo sapiens_hsa054160.61146459
62Allograft rejection_Homo sapiens_hsa053300.60888916
63Starch and sucrose metabolism_Homo sapiens_hsa005000.60721562
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60175760
65Estrogen signaling pathway_Homo sapiens_hsa049150.59881098
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58480298
67Notch signaling pathway_Homo sapiens_hsa043300.58022146
68Non-homologous end-joining_Homo sapiens_hsa034500.57949400
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57103336
70Prolactin signaling pathway_Homo sapiens_hsa049170.56936095
71Systemic lupus erythematosus_Homo sapiens_hsa053220.56396724
72Chronic myeloid leukemia_Homo sapiens_hsa052200.55628860
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55000582
74Small cell lung cancer_Homo sapiens_hsa052220.54129684
75African trypanosomiasis_Homo sapiens_hsa051430.53020100
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51891016
77Influenza A_Homo sapiens_hsa051640.50510340
78Arachidonic acid metabolism_Homo sapiens_hsa005900.49710656
79Salmonella infection_Homo sapiens_hsa051320.49188951
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48486835
81Glioma_Homo sapiens_hsa052140.48297567
82Renin secretion_Homo sapiens_hsa049240.48195532
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47633830
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47413535
85Herpes simplex infection_Homo sapiens_hsa051680.47094963
86Pancreatic cancer_Homo sapiens_hsa052120.46912800
87Epstein-Barr virus infection_Homo sapiens_hsa051690.46460673
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.45715273
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.45507530
90Renin-angiotensin system_Homo sapiens_hsa046140.45373724
91Retinol metabolism_Homo sapiens_hsa008300.44355999
92MAPK signaling pathway_Homo sapiens_hsa040100.43359434
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43110256
94HIF-1 signaling pathway_Homo sapiens_hsa040660.42473601
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.42334862
96Focal adhesion_Homo sapiens_hsa045100.42294424
97Cocaine addiction_Homo sapiens_hsa050300.41819445
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41738973
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40723308
100Fructose and mannose metabolism_Homo sapiens_hsa000510.39462456
101Chemical carcinogenesis_Homo sapiens_hsa052040.39047386
102Bladder cancer_Homo sapiens_hsa052190.38705851
103Dorso-ventral axis formation_Homo sapiens_hsa043200.38572143
104TNF signaling pathway_Homo sapiens_hsa046680.38224184
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38131112
106ECM-receptor interaction_Homo sapiens_hsa045120.37781700
107Glucagon signaling pathway_Homo sapiens_hsa049220.36971074
108ABC transporters_Homo sapiens_hsa020100.36969200
109Endocytosis_Homo sapiens_hsa041440.36868647
110HTLV-I infection_Homo sapiens_hsa051660.36741440
111Hepatitis C_Homo sapiens_hsa051600.36371754
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35408199
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34691969
114Inositol phosphate metabolism_Homo sapiens_hsa005620.34093273
115Vibrio cholerae infection_Homo sapiens_hsa051100.33725736
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.33535923
117Legionellosis_Homo sapiens_hsa051340.32322001
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32105606
119Viral carcinogenesis_Homo sapiens_hsa052030.31938990
120Renal cell carcinoma_Homo sapiens_hsa052110.31312771
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30323895
122Insulin secretion_Homo sapiens_hsa049110.29328639
123Shigellosis_Homo sapiens_hsa051310.28827127
124Circadian entrainment_Homo sapiens_hsa047130.28672464
125Dopaminergic synapse_Homo sapiens_hsa047280.27648419
126Cholinergic synapse_Homo sapiens_hsa047250.27603548
127Arginine biosynthesis_Homo sapiens_hsa002200.25280433
128Phenylalanine metabolism_Homo sapiens_hsa003600.25043692
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23377676
130ErbB signaling pathway_Homo sapiens_hsa040120.22729969
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.22564333
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.22172492
133Prostate cancer_Homo sapiens_hsa052150.21576561
134Histidine metabolism_Homo sapiens_hsa003400.21089442
135GnRH signaling pathway_Homo sapiens_hsa049120.20341452
136Lysosome_Homo sapiens_hsa041420.19830421
137Autoimmune thyroid disease_Homo sapiens_hsa053200.19568277

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