IGHV2-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein activation cascade (GO:0072376)8.91391488
2immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00028.29529243
3Fc-gamma receptor signaling pathway (GO:0038094)8.29529243
4Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)8.29529243
5Fc receptor mediated stimulatory signaling pathway (GO:0002431)8.18695980
6positive regulation of respiratory burst (GO:0060267)7.57017470
7retina homeostasis (GO:0001895)7.24163780
8humoral immune response (GO:0006959)7.22734985
9positive regulation of B cell differentiation (GO:0045579)6.59378513
10negative regulation of B cell proliferation (GO:0030889)6.50480198
11B cell receptor signaling pathway (GO:0050853)6.49382608
12antigen processing and presentation of endogenous antigen (GO:0019883)6.38143129
13glomerular filtration (GO:0003094)6.23658630
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.75513504
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.75513504
16regulation of B cell differentiation (GO:0045577)5.59531380
17renal filtration (GO:0097205)5.57586682
18negative regulation of glucose import (GO:0046325)5.37336292
19myeloid dendritic cell differentiation (GO:0043011)5.33303654
20immune response-activating cell surface receptor signaling pathway (GO:0002429)5.25857257
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.15597528
22Golgi transport vesicle coating (GO:0048200)5.11744489
23COPI coating of Golgi vesicle (GO:0048205)5.11744489
24regulation of B cell proliferation (GO:0030888)5.09859716
25positive regulation of Rho protein signal transduction (GO:0035025)5.09055642
26positive regulation of gamma-delta T cell activation (GO:0046645)4.83280885
27regulation of respiratory burst (GO:0060263)4.82326784
28myeloid dendritic cell activation (GO:0001773)4.69538672
29cellular extravasation (GO:0045123)4.63797091
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.52104788
31regulation of glucose import in response to insulin stimulus (GO:2001273)4.49790448
32negative regulation of glucose transport (GO:0010829)4.41590833
33negative regulation of bone resorption (GO:0045779)4.40772339
34regulation of B cell receptor signaling pathway (GO:0050855)4.39320815
35response to protozoan (GO:0001562)4.25720761
36fucose catabolic process (GO:0019317)4.25406733
37L-fucose metabolic process (GO:0042354)4.25406733
38L-fucose catabolic process (GO:0042355)4.25406733
39positive regulation of Rap GTPase activity (GO:0032854)4.23602907
40cellular response to zinc ion (GO:0071294)4.21815461
41detection of bacterium (GO:0016045)4.16810346
42mature B cell differentiation (GO:0002335)4.13654076
43ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.05766612
44detection of other organism (GO:0098543)4.02062325
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.87010577
46positive thymic T cell selection (GO:0045059)3.81260302
47N-acetylneuraminate metabolic process (GO:0006054)3.75087232
48regulation of Rap GTPase activity (GO:0032317)3.71297810
49regulation of gamma-delta T cell differentiation (GO:0045586)3.70305228
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67599605
51mannose metabolic process (GO:0006013)3.64843704
52signal peptide processing (GO:0006465)3.64786723
53positive regulation of immunoglobulin production (GO:0002639)3.61490650
54immune response-activating signal transduction (GO:0002757)3.59616743
55regulation of B cell activation (GO:0050864)3.57568116
56dendritic cell differentiation (GO:0097028)3.56454712
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53239917
58B cell proliferation (GO:0042100)3.52822619
59regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.48420475
60antibacterial humoral response (GO:0019731)3.46221025
61activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.44571739
62Fc receptor signaling pathway (GO:0038093)3.44412912
63negative regulation of bone remodeling (GO:0046851)3.44209758
64immune response-regulating cell surface receptor signaling pathway (GO:0002768)3.43911687
65regulation of interferon-beta biosynthetic process (GO:0045357)3.43583010
66negative regulation of B cell activation (GO:0050869)3.43076865
67antimicrobial humoral response (GO:0019730)3.40820505
68B cell homeostasis (GO:0001782)3.39180040
69maternal placenta development (GO:0001893)3.39081600
70cellular response to type I interferon (GO:0071357)3.38550841
71type I interferon signaling pathway (GO:0060337)3.38550841
72bone resorption (GO:0045453)3.38118766
73hepatocyte apoptotic process (GO:0097284)3.37673478
74positive regulation of nuclease activity (GO:0032075)3.37239421
75protein retention in ER lumen (GO:0006621)3.37009968
76Fc-epsilon receptor signaling pathway (GO:0038095)3.35790138
77protein N-linked glycosylation via asparagine (GO:0018279)3.33981600
78regulation of gamma-delta T cell activation (GO:0046643)3.33022265
79peptidyl-asparagine modification (GO:0018196)3.30892327
80activation of immune response (GO:0002253)3.24018711
81negative regulation of osteoclast differentiation (GO:0045671)3.22514585
82dendritic cell chemotaxis (GO:0002407)3.20745625
83regulation of interleukin-12 biosynthetic process (GO:0045075)3.20709059
84apoptotic cell clearance (GO:0043277)3.20642199
85regulation of nuclease activity (GO:0032069)3.20161560
86N-glycan processing (GO:0006491)3.19688955
87regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.19154043
88mature B cell differentiation involved in immune response (GO:0002313)3.18706663
89positive regulation of B cell activation (GO:0050871)3.13451827
90thymic T cell selection (GO:0045061)3.13366775
91endoplasmic reticulum unfolded protein response (GO:0030968)3.13321719
92intestinal epithelial cell development (GO:0060576)3.13157730
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12480043
94negative thymic T cell selection (GO:0045060)3.11785357
95antigen receptor-mediated signaling pathway (GO:0050851)3.11616030
96protein N-linked glycosylation (GO:0006487)3.08069295
97response to hydroperoxide (GO:0033194)3.06881681
98tolerance induction (GO:0002507)3.06578972
99regulation of type I interferon-mediated signaling pathway (GO:0060338)3.06369323
100response to interferon-alpha (GO:0035455)3.02870141
101cellular response to unfolded protein (GO:0034620)3.02679697
102natural killer cell differentiation (GO:0001779)3.00463755
103respiratory burst (GO:0045730)3.00389819
104regulation of cellular extravasation (GO:0002691)2.99324007
105positive regulation of B cell proliferation (GO:0030890)2.98010421
106response to endoplasmic reticulum stress (GO:0034976)2.95836460
107lymphocyte chemotaxis (GO:0048247)2.94093893
108negative T cell selection (GO:0043383)2.92098306
109negative regulation of cell killing (GO:0031342)2.91941354
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91941354
111T cell selection (GO:0045058)2.89499237
112negative regulation of tissue remodeling (GO:0034104)2.86928481
113regulation of water loss via skin (GO:0033561)2.86843186
114interferon-gamma-mediated signaling pathway (GO:0060333)2.85542991
115regulation of superoxide anion generation (GO:0032928)2.85155070
116lymphocyte homeostasis (GO:0002260)2.83312769
117surfactant homeostasis (GO:0043129)2.82276194
118chronic inflammatory response (GO:0002544)2.81400810
119ER-nucleus signaling pathway (GO:0006984)2.80678358
120positive regulation of histone deacetylation (GO:0031065)2.80539991
121germinal center formation (GO:0002467)2.80151303
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80041365
123regulation of fibroblast apoptotic process (GO:2000269)2.79763271
124cellular response to topologically incorrect protein (GO:0035967)2.79597953
125detection of external biotic stimulus (GO:0098581)2.78812968
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78037481
127defense response to protozoan (GO:0042832)2.74815310
128establishment of skin barrier (GO:0061436)2.73834578
129B cell activation (GO:0042113)2.73813729
130positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.73586917
131regulation of interferon-alpha production (GO:0032647)2.70095958
132cellular response to antibiotic (GO:0071236)2.70090030
133regulation of immunoglobulin production (GO:0002637)2.68807197
134COPII vesicle coating (GO:0048208)2.68487380
135response to type I interferon (GO:0034340)2.68460404
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.67591638
137positive T cell selection (GO:0043368)2.67384801
138regulation of germinal center formation (GO:0002634)2.66453356
139positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64909560
140dendritic cell migration (GO:0036336)2.64742483
141innate immune response in mucosa (GO:0002227)2.62063822
142interleukin-6-mediated signaling pathway (GO:0070102)2.61437614
143regulation of antigen processing and presentation (GO:0002577)2.59732786
144immunoglobulin mediated immune response (GO:0016064)2.58975599
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56499545
146regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56337707
147keratinization (GO:0031424)2.53486611
148organ or tissue specific immune response (GO:0002251)2.51966626
149interferon-gamma secretion (GO:0072643)2.48321413
150T cell migration (GO:0072678)2.47752379
151defense response to Gram-negative bacterium (GO:0050829)2.47739816
152multicellular organismal water homeostasis (GO:0050891)2.45522640
153positive regulation of antigen processing and presentation (GO:0002579)2.45118935
154phospholipid translocation (GO:0045332)2.44743546
155lipid translocation (GO:0034204)2.44743546
156regulation of integrin activation (GO:0033623)2.44167322
157negative regulation of myotube differentiation (GO:0010832)2.43613598
158protein-chromophore linkage (GO:0018298)2.42545338
159complement activation, classical pathway (GO:0006958)18.0928467
160complement activation (GO:0006956)13.8541076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.04685793
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.76666941
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.61324248
4MYC_22102868_ChIP-Seq_BL_Human4.61023498
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05207351
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.86719815
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.73668708
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.62712509
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.51903343
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.48438500
11VDR_21846776_ChIP-Seq_THP-1_Human3.35618985
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27543475
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.11304120
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.10702026
15BP1_19119308_ChIP-ChIP_Hs578T_Human3.05888889
16RUNX_20019798_ChIP-Seq_JUKART_Human2.96286034
17MAF_26560356_Chip-Seq_TH1_Human2.81014395
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.75092989
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.74681776
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64445451
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60761396
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50412054
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49739682
24MYB_26560356_Chip-Seq_TH1_Human2.48722998
25MYB_26560356_Chip-Seq_TH2_Human2.33855019
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.28155019
27VDR_24763502_ChIP-Seq_THP-1_Human2.27418373
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25543557
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24929248
30CLOCK_20551151_ChIP-Seq_293T_Human2.23305067
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17826844
32UTX_26944678_Chip-Seq_JUKART_Human2.14842615
33TCF7_22412390_ChIP-Seq_EML_Mouse2.11545543
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03188171
35KDM2B_26808549_Chip-Seq_DND41_Human2.01941693
36E2F7_22180533_ChIP-Seq_HELA_Human1.96991547
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93082570
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88180362
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84248041
40SCL_19346495_ChIP-Seq_HPC-7_Human1.81672120
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79273722
42SPI1_23127762_ChIP-Seq_K562_Human1.77919922
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.76729428
44SPI1_23547873_ChIP-Seq_NB4_Human1.74950769
45MAF_26560356_Chip-Seq_TH2_Human1.70031659
46GATA3_27048872_Chip-Seq_THYMUS_Human1.67576850
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.65484702
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65271551
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63630650
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62645202
51GATA1_22025678_ChIP-Seq_K562_Human1.61764890
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55687277
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53603121
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47850478
55PU.1_20513432_ChIP-Seq_Bcells_Mouse1.47621616
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45074728
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43634704
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42051336
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.41911192
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.39052667
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38724911
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37177046
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36107295
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35878310
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35486966
66GATA3_26560356_Chip-Seq_TH2_Human1.33458483
67RACK7_27058665_Chip-Seq_MCF-7_Human1.30969177
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30667551
69LXR_22292898_ChIP-Seq_THP-1_Human1.28054722
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27225189
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26280293
72GATA6_25053715_ChIP-Seq_YYC3_Human1.23781607
73DROSHA_22980978_ChIP-Seq_HELA_Human1.22555905
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20685226
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16573187
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16484871
77PU_27001747_Chip-Seq_BMDM_Mouse1.15782130
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14117769
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.13655190
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.12430788
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12409361
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09748500
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06805772
84GATA4_25053715_ChIP-Seq_YYC3_Human1.05111805
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04438300
86SMRT_27268052_Chip-Seq_Bcells_Human1.03460551
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02839448
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01335460
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.01039560
90P300_27268052_Chip-Seq_Bcells_Human1.00595088
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.00453691
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99635855
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99153416
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99144099
95CDX2_20551321_ChIP-Seq_CACO-2_Human0.98566711
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.97998905
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95807408
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.94695611
99GATA2_19941826_ChIP-Seq_K562_Human0.93823510
100SOX2_20726797_ChIP-Seq_SW620_Human0.93423773
101LXR_22158963_ChIP-Seq_LIVER_Mouse0.92996665
102TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92920764
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92538778
104VDR_24787735_ChIP-Seq_THP-1_Human0.92070699
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91415866
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91211823
107SPI1_20517297_ChIP-Seq_HL60_Human0.90840606
108NCOR1_26117541_ChIP-Seq_K562_Human0.90577018
109GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90483916
110SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89891195
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88808646
112GATA3_26560356_Chip-Seq_TH1_Human0.88580537
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88295963
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87932927
115CIITA_25753668_ChIP-Seq_RAJI_Human0.87886390
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87584756
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87156831
118SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86322255
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.84698259
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84094989
121BCL6_27268052_Chip-Seq_Bcells_Human0.82976779
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82140042
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82115555
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82061914
125GATA1_19941826_ChIP-Seq_K562_Human0.82025144
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.81149077
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76598299
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75066383
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74202215
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73492068
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72870308
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71887237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.53609249
2MP0001835_abnormal_antigen_presentation5.00731289
3MP0001800_abnormal_humoral_immune4.75235799
4MP0001790_abnormal_immune_system3.87483415
5MP0005387_immune_system_phenotype3.87483415
6MP0002452_abnormal_antigen_presenting3.54333474
7MP0003724_increased_susceptibility_to3.35102452
8MP0005671_abnormal_response_to3.31927555
9MP0003300_gastrointestinal_ulcer3.30153597
10MP0002723_abnormal_immune_serum3.03048330
11MP0002420_abnormal_adaptive_immunity2.86430106
12MP0001819_abnormal_immune_cell2.80182168
13MP0005000_abnormal_immune_tolerance2.73954359
14MP0005275_abnormal_skin_tensile2.66451578
15MP0002398_abnormal_bone_marrow2.66283660
16MP0000716_abnormal_immune_system2.60509698
17MP0000685_abnormal_immune_system2.58954652
18MP0004264_abnormal_extraembryonic_tissu2.49545585
19MP0000689_abnormal_spleen_morphology2.41771841
20MP0001879_abnormal_lymphatic_vessel2.19631363
21MP0005025_abnormal_response_to2.16694141
22MP0005503_abnormal_tendon_morphology2.14507405
23MP0003436_decreased_susceptibility_to2.14147395
24MP0002429_abnormal_blood_cell2.09719422
25MP0004782_abnormal_surfactant_physiolog2.00385261
26MP0003045_fibrosis1.96841831
27MP0002722_abnormal_immune_system1.95014313
28MP0008438_abnormal_cutaneous_collagen1.92277394
29MP0002419_abnormal_innate_immunity1.87585228
30MP0003763_abnormal_thymus_physiology1.86577403
31MP0010155_abnormal_intestine_physiology1.86489331
32MP0001845_abnormal_inflammatory_respons1.83376351
33MP0003866_abnormal_defecation1.77502260
34MP0002396_abnormal_hematopoietic_system1.77414527
35MP0002796_impaired_skin_barrier1.76398555
36MP0002148_abnormal_hypersensitivity_rea1.73409526
37MP0002166_altered_tumor_susceptibility1.69291662
38MP0009333_abnormal_splenocyte_physiolog1.69189465
39MP0001873_stomach_inflammation1.59916452
40MP0004947_skin_inflammation1.58362736
41MP0006054_spinal_hemorrhage1.42967985
42MP0002405_respiratory_system_inflammati1.41700470
43MP0005166_decreased_susceptibility_to1.39168931
44MP0002138_abnormal_hepatobiliary_system1.38555709
45MP0000858_altered_metastatic_potential1.38239423
46MP0009785_altered_susceptibility_to1.37733982
47MP0002933_joint_inflammation1.35659511
48MP0010234_abnormal_vibrissa_follicle1.31864874
49MP0000703_abnormal_thymus_morphology1.30287750
50MP0004510_myositis1.26811886
51MP0005464_abnormal_platelet_physiology1.26008487
52MP0002006_tumorigenesis1.21534129
53MP0003453_abnormal_keratinocyte_physiol1.20211092
54MP0001851_eye_inflammation1.18045229
55MP0002019_abnormal_tumor_incidence1.16969771
56MP0010307_abnormal_tumor_latency1.16098836
57MP0004858_abnormal_nervous_system1.15440736
58MP0001270_distended_abdomen1.12394127
59MP0005310_abnormal_salivary_gland1.11510496
60MP0004147_increased_porphyrin_level1.10910365
61MP0005390_skeleton_phenotype1.10433010
62MP0001663_abnormal_digestive_system1.10198319
63MP0004808_abnormal_hematopoietic_stem1.08922670
64MP0005058_abnormal_lysosome_morphology1.08911382
65MP0000465_gastrointestinal_hemorrhage1.05324650
66MP0008260_abnormal_autophagy1.03111165
67MP0001853_heart_inflammation1.02255494
68MP0003868_abnormal_feces_composition1.02028073
69MP0002168_other_aberrant_phenotype1.00576527
70MP0002139_abnormal_hepatobiliary_system0.98530949
71MP0001216_abnormal_epidermal_layer0.98185399
72MP0002876_abnormal_thyroid_physiology0.98090235
73MP0009840_abnormal_foam_cell0.98003812
74MP0008004_abnormal_stomach_pH0.97129999
75MP0002060_abnormal_skin_morphology0.96637727
76MP0001533_abnormal_skeleton_physiology0.96307504
77MP0008874_decreased_physiological_sensi0.96056808
78MP0008469_abnormal_protein_level0.95920152
79MP0000681_abnormal_thyroid_gland0.95898438
80MP0005164_abnormal_response_to0.94254884
81MP0003448_altered_tumor_morphology0.93593774
82MP0003279_aneurysm0.93138741
83MP0000733_abnormal_muscle_development0.92035937
84MP0003252_abnormal_bile_duct0.91876964
85MP0009931_abnormal_skin_appearance0.91664423
86MP0003075_altered_response_to0.90742218
87MP0003828_pulmonary_edema0.89797794
88MP0002136_abnormal_kidney_physiology0.89729786
89MP0008872_abnormal_physiological_respon0.88528473
90MP0000490_abnormal_crypts_of0.87851142
91MP0006082_CNS_inflammation0.86840034
92MP0002277_abnormal_respiratory_mucosa0.86211309
93MP0008569_lethality_at_weaning0.84841588
94MP0003191_abnormal_cellular_cholesterol0.84206754
95MP0002998_abnormal_bone_remodeling0.84170578
96MP0003183_abnormal_peptide_metabolism0.82590598
97MP0000343_altered_response_to0.80869543
98MP0005501_abnormal_skin_physiology0.80229852
99MP0005076_abnormal_cell_differentiation0.79844009
100MP0000920_abnormal_myelination0.79498592
101MP0002693_abnormal_pancreas_physiology0.75542640
102MP0005360_urolithiasis0.75537474
103MP0002896_abnormal_bone_mineralization0.75369947
104MP0009763_increased_sensitivity_to0.75026132
105MP0000604_amyloidosis0.75015333
106MP0003091_abnormal_cell_migration0.74268300
107MP0000371_diluted_coat_color0.73937355
108MP0004084_abnormal_cardiac_muscle0.73625495
109MP0009046_muscle_twitch0.73505752
110MP0000377_abnormal_hair_follicle0.73438663
111MP0003787_abnormal_imprinting0.73098081
112MP0009764_decreased_sensitivity_to0.72312112
113MP0000579_abnormal_nail_morphology0.72041386
114MP0003566_abnormal_cell_adhesion0.71175606
115MP0005023_abnormal_wound_healing0.70039654
116MP0000609_abnormal_liver_physiology0.69502633
117MP0005584_abnormal_enzyme/coenzyme_acti0.68764015
118MP0008873_increased_physiological_sensi0.67832376
119MP0005381_digestive/alimentary_phenotyp0.67374457
120MP0000477_abnormal_intestine_morphology0.63885861
121MP0002083_premature_death0.63065048
122MP0001944_abnormal_pancreas_morphology0.63054529
123MP0001919_abnormal_reproductive_system0.62268398
124MP0010352_gastrointestinal_tract_polyps0.60885034
125MP0008875_abnormal_xenobiotic_pharmacok0.58794257
126MP0005451_abnormal_body_composition0.55913407
127MP0002254_reproductive_system_inflammat0.55123289
128MP0005220_abnormal_exocrine_pancreas0.54736526
129MP0003656_abnormal_erythrocyte_physiolo0.54232451
130MP0002133_abnormal_respiratory_system0.52916398
131MP0005388_respiratory_system_phenotype0.52916398
132MP0000003_abnormal_adipose_tissue0.52718050
133MP0003795_abnormal_bone_structure0.50411751
134MP0009643_abnormal_urine_homeostasis0.47281396
135MP0005085_abnormal_gallbladder_physiolo0.45386431
136MP0002169_no_abnormal_phenotype0.44525794
137MP0002873_normal_phenotype0.44368139
138MP0000249_abnormal_blood_vessel0.44058898
139MP0001191_abnormal_skin_condition0.43751040

Predicted human phenotypes

RankGene SetZ-score
1Colitis (HP:0002583)8.75010273
2B lymphocytopenia (HP:0010976)8.06694353
3Abnormality of B cell number (HP:0010975)8.06694353
4Recurrent sinusitis (HP:0011108)7.03571069
5Inflammation of the large intestine (HP:0002037)6.59225318
6Cellulitis (HP:0100658)6.55962442
7Gastrointestinal inflammation (HP:0004386)6.32912906
8Recurrent bronchitis (HP:0002837)6.20129729
9Recurrent viral infections (HP:0004429)6.18924301
10Prostate neoplasm (HP:0100787)5.95286086
11Papilloma (HP:0012740)5.74115178
12Verrucae (HP:0200043)5.74115178
13Gastrointestinal stroma tumor (HP:0100723)5.42418042
14IgM deficiency (HP:0002850)5.21699363
15Panhypogammaglobulinemia (HP:0003139)5.06033220
16Meningitis (HP:0001287)5.02019056
17Abnormality of macrophages (HP:0004311)4.89722708
18Systemic lupus erythematosus (HP:0002725)4.78358065
19Recurrent pneumonia (HP:0006532)4.74425417
20Abnormal delayed hypersensitivity skin test (HP:0002963)4.50385749
21Chronic otitis media (HP:0000389)4.35080883
22Recurrent lower respiratory tract infections (HP:0002783)4.32103211
23Osteomyelitis (HP:0002754)3.87130009
24Abnormality of the prostate (HP:0008775)3.86926498
25Chronic sinusitis (HP:0011109)3.83872913
26Emphysema (HP:0002097)3.64345108
27Recurrent otitis media (HP:0000403)3.61399724
28Abnormality of T cell physiology (HP:0011840)3.58289438
29Malnutrition (HP:0004395)3.58027368
30Bronchitis (HP:0012387)3.44135278
31Alopecia of scalp (HP:0002293)3.43083382
32Sepsis (HP:0100806)3.28826353
33Recurrent fungal infections (HP:0002841)3.28751074
34IgA deficiency (HP:0002720)3.15837662
35Chronic mucocutaneous candidiasis (HP:0002728)3.14377938
36Recurrent cutaneous fungal infections (HP:0011370)3.14377938
37Urticaria (HP:0001025)3.10730993
38Thyroiditis (HP:0100646)3.09712355
39Glomerulonephritis (HP:0000099)3.09297634
40Thick nail (HP:0001805)3.06315118
41Lymphopenia (HP:0001888)3.02436027
42Abnormality of complement system (HP:0005339)3.01271310
43Vasculitis (HP:0002633)3.00957100
44Skin rash (HP:0000988)2.90522853
45Restrictive lung disease (HP:0002091)2.90068984
46Viral hepatitis (HP:0006562)2.89607689
47Abnormality of nail color (HP:0100643)2.87250303
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.86927348
49Leukocytosis (HP:0001974)2.80408186
50Abnormality of T cells (HP:0002843)2.79604388
51Nephritis (HP:0000123)2.79562727
52Hypergammaglobulinemia (HP:0010702)2.79503927
53Complement deficiency (HP:0004431)2.74489014
54IgG deficiency (HP:0004315)2.74179770
55Spontaneous hematomas (HP:0007420)2.72391417
56Autoimmune hemolytic anemia (HP:0001890)2.72114093
57Recurrent skin infections (HP:0001581)2.64185939
58Gingivitis (HP:0000230)2.63063201
59Premature loss of primary teeth (HP:0006323)2.55440836
60Small epiphyses (HP:0010585)2.52606274
61Abnormal hair laboratory examination (HP:0003328)2.45927472
62Interstitial pulmonary disease (HP:0006530)2.45825790
63Recurrent bacterial skin infections (HP:0005406)2.40901930
64Metaphyseal cupping (HP:0003021)2.39743153
65Nasal polyposis (HP:0100582)2.39428171
66Recurrent abscess formation (HP:0002722)2.38481758
67Gastrointestinal infarctions (HP:0005244)2.38164386
68Polycythemia (HP:0001901)2.35939869
69Hyperactive renin-angiotensin system (HP:0000841)2.35819915
70Right ventricular cardiomyopathy (HP:0011663)2.29753974
71Increased IgE level (HP:0003212)2.27305035
72Hypochromic microcytic anemia (HP:0004840)2.27288933
73Periodontitis (HP:0000704)2.27133385
74Erythema (HP:0010783)2.25064445
75Palmoplantar hyperkeratosis (HP:0000972)2.22567496
76Mitral stenosis (HP:0001718)2.21474088
77Abnormality of glycolipid metabolism (HP:0010969)2.21437028
78Abnormality of liposaccharide metabolism (HP:0010968)2.21437028
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.21437028
80Neutropenia (HP:0001875)2.17261725
81Hypermelanotic macule (HP:0001034)2.16419591
82Chronic diarrhea (HP:0002028)2.15916753
83Skin ulcer (HP:0200042)2.15490151
84Ankyloglossia (HP:0010296)2.14657887
85Bronchiectasis (HP:0002110)2.14147264
86Pulmonary infiltrates (HP:0002113)2.13516147
87Encephalitis (HP:0002383)2.11562660
88Mediastinal lymphadenopathy (HP:0100721)2.10751516
89Abnormality of male internal genitalia (HP:0000022)2.10144340
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.08885857
91Neoplasm of the lung (HP:0100526)2.06464139
92Pili torti (HP:0003777)2.05653745
93Gingival bleeding (HP:0000225)2.05529699
94Palmar hyperkeratosis (HP:0010765)2.05505808
95Neoplasm of head and neck (HP:0012288)2.04250059
96Esophageal neoplasm (HP:0100751)2.04250059
97Generalized hypopigmentation of hair (HP:0011358)2.00271781
98Agammaglobulinemia (HP:0004432)10.4823581
99Abnormality of the nasal mucosa (HP:0000433)1.99887452
100Hypochromic anemia (HP:0001931)1.99174355
101Vertebral compression fractures (HP:0002953)1.97734158
102Hyperparathyroidism (HP:0000843)1.94525707
103Plantar hyperkeratosis (HP:0007556)1.94343380
104Ileus (HP:0002595)1.93603742
105Eczematoid dermatitis (HP:0000976)1.93403838
106Leukopenia (HP:0001882)1.91557522
107Microcytic anemia (HP:0001935)1.90980724
108Abnormality of small intestinal villus morphology (HP:0011472)1.90119500
109Villous atrophy (HP:0011473)1.90119500
110Follicular hyperkeratosis (HP:0007502)1.89780762
111Dysostosis multiplex (HP:0000943)1.89098809
112Hemoptysis (HP:0002105)1.87692093
113Nonimmune hydrops fetalis (HP:0001790)1.86587526
114T lymphocytopenia (HP:0005403)1.85630135
115Abnormality of T cell number (HP:0011839)1.85268548
116Abnormality of the fingertips (HP:0001211)1.84073883
117Purpura (HP:0000979)1.83657258
118Granulocytopenia (HP:0001913)1.83365781
119Acrocyanosis (HP:0001063)1.83201309
120Fragile skin (HP:0001030)1.82404333
121Hepatitis (HP:0012115)1.79237318
122Vacuolated lymphocytes (HP:0001922)1.78958661
123Severe combined immunodeficiency (HP:0004430)1.76688121
124Combined immunodeficiency (HP:0005387)1.76099828
125Lymphoma (HP:0002665)1.71853293
126Loss of speech (HP:0002371)1.68055363
127Arthralgia (HP:0002829)1.67216915
128Basal cell carcinoma (HP:0002671)1.66867492
129Thyroid-stimulating hormone excess (HP:0002925)1.65914053
130Thrombocytosis (HP:0001894)1.65577488
131Dehydration (HP:0001944)1.63244596
132Flattened epiphyses (HP:0003071)1.63055818
133Recurrent gram-negative bacterial infections (HP:0005420)1.61973340
134Obstructive lung disease (HP:0006536)1.61943029
135Chronic obstructive pulmonary disease (HP:0006510)1.61943029
136Elevated erythrocyte sedimentation rate (HP:0003565)1.61549550
137Ocular albinism (HP:0001107)1.58303696
138Xerostomia (HP:0000217)1.54670755
139Pustule (HP:0200039)1.53364407
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.50111942
141Myositis (HP:0100614)1.48248861
142Hypertensive crisis (HP:0100735)1.46443877
143Spondylolisthesis (HP:0003302)1.45258440
144Teleangiectasia of the skin (HP:0100585)1.44270990
145Prominent nose (HP:0000448)1.43680004
146Abnormality of the lumbar spine (HP:0100712)1.42103747
147Thoracic kyphosis (HP:0002942)1.41582930
148Hypoplasia of the thymus (HP:0000778)1.40123762
149Autoimmune thrombocytopenia (HP:0001973)1.39683383
150Chest pain (HP:0100749)1.38096949
151Abnormal foot bone ossification (HP:0010675)1.34348758
152Abnormality of the common coagulation pathway (HP:0010990)1.34008304
153Macroorchidism (HP:0000053)1.33795919
154Urinary glycosaminoglycan excretion (HP:0003541)1.32210430
155Mucopolysacchariduria (HP:0008155)1.32210430
156Alacrima (HP:0000522)1.32143681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.52765426
2MAP4K15.36272206
3PRPF4B3.61681877
4EEF2K3.20901001
5TAOK32.95927154
6MAP3K102.95537030
7RIPK42.74635850
8GRK62.73583779
9EIF2AK32.39766904
10TYK22.39026981
11SYK2.20561752
12IRAK32.12239070
13CSF1R2.09461460
14RIPK12.09157672
15BLK1.98179885
16SIK21.97845438
17TNIK1.75407838
18KIT1.74086272
19MAP2K31.67617573
20FES1.64991611
21MST1R1.64620010
22NME21.59166269
23MAP3K141.58199618
24JAK11.55287910
25EPHA31.55256102
26BTK1.52656174
27TBK11.52202063
28MAP3K61.51114902
29SIK31.43375300
30PRKCH1.43159026
31IKBKB1.39958928
32STK101.26551999
33LYN1.23591024
34MAP3K131.23388428
35IKBKE1.19914803
36EPHA21.17911030
37ITK1.17217145
38HCK1.14645762
39IRAK41.12130224
40HIPK21.10184142
41CDK31.09768847
42JAK31.07452825
43STK241.05993524
44LRRK21.05092752
45CDK121.04981670
46MET1.01162566
47TGFBR11.01112299
48MAP3K10.98054958
49YES10.97275612
50MAPK70.96328092
51ZAP700.95981636
52RPS6KA40.94207030
53PAK40.91573955
54PRKD20.91221793
55MAP3K40.89536829
56PRKCQ0.87724632
57NLK0.86270862
58CDK60.85789453
59FGFR40.82468835
60TGFBR20.81373699
61TXK0.79695180
62MAPK120.78128596
63PIK3CA0.77735164
64CSK0.77651407
65LCK0.77370563
66DYRK1B0.76795863
67TAOK10.76545641
68PIK3CG0.76239203
69NUAK10.75600135
70TEC0.74029291
71PIM10.73787425
72SMG10.73617180
73TRIB30.72519163
74NEK20.70999747
75MAP3K30.68560638
76ALK0.64971920
77NEK90.64225882
78FGFR30.63748255
79DDR20.63037925
80PDGFRA0.58847958
81BMX0.57282985
82SIK10.55879656
83EIF2AK10.55714595
84MAP3K70.55326971
85CLK10.54889295
86FER0.53276180
87PDPK10.52664690
88PDK10.51400011
89MAPK110.50314558
90MELK0.49543393
91FYN0.49162078
92RPS6KB20.47942845
93STK40.45416636
94CHUK0.45018957
95BMPR20.44567744
96MAPKAPK30.43292421
97MAP2K40.42500673
98PRKD10.42213105
99PKN20.41551168
100MAP2K60.40496981
101EPHB10.40388091
102JAK20.38941373
103MAP3K90.37027531
104TESK20.36832882
105BRD40.35882733
106EGFR0.35100138
107MST40.34288027
108MARK30.34042059
109DMPK0.33371673
110TAOK20.33360497
111INSR0.32247837
112ARAF0.32240174
113PKN10.31644851
114MAPKAPK20.31619087
115MAPK30.31469668
116CDK40.31381718
117ACVR1B0.31256298
118KSR20.30909538
119RAF10.28260102
120CSNK1A1L0.28139520
121FLT30.27537631
122MAPK40.27033573
123MAP2K10.26962935
124FGR0.25772207
125CDK90.25531247
126MARK20.25467773
127MAP3K110.25370608
128PRKCD0.25024989
129ABL10.23123541
130PRKCI0.21315254
131RET0.20753358
132CSNK1G30.20596958
133IGF1R0.20178029
134CDC42BPA0.19269908
135IRAK10.17774533

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046727.21273765
2Primary immunodeficiency_Homo sapiens_hsa053406.09765850
3B cell receptor signaling pathway_Homo sapiens_hsa046624.69190633
4N-Glycan biosynthesis_Homo sapiens_hsa005102.88135639
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.58362379
6Protein export_Homo sapiens_hsa030602.36093108
7Graft-versus-host disease_Homo sapiens_hsa053322.27965925
8Osteoclast differentiation_Homo sapiens_hsa043802.16850312
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.11457739
10Leishmaniasis_Homo sapiens_hsa051401.87864708
11Antigen processing and presentation_Homo sapiens_hsa046121.81751929
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76136583
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76021447
14Type I diabetes mellitus_Homo sapiens_hsa049401.74866926
15T cell receptor signaling pathway_Homo sapiens_hsa046601.67725328
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67506386
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63327466
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62713782
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52248462
20Asthma_Homo sapiens_hsa053101.42773087
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41541591
22Tuberculosis_Homo sapiens_hsa051521.28682980
23Measles_Homo sapiens_hsa051621.22149174
24Sulfur metabolism_Homo sapiens_hsa009201.18310216
25Chemokine signaling pathway_Homo sapiens_hsa040621.18141903
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17486645
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16101440
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12056250
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.02334672
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.01471434
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99806184
32Rheumatoid arthritis_Homo sapiens_hsa053230.98320278
33Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96909031
34Renin-angiotensin system_Homo sapiens_hsa046140.95817859
35Phagosome_Homo sapiens_hsa041450.95674946
36Hematopoietic cell lineage_Homo sapiens_hsa046400.95365231
37Pertussis_Homo sapiens_hsa051330.93065900
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92804555
39Malaria_Homo sapiens_hsa051440.92329980
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91914856
41Acute myeloid leukemia_Homo sapiens_hsa052210.91045211
42Herpes simplex infection_Homo sapiens_hsa051680.89574023
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88247641
44Non-homologous end-joining_Homo sapiens_hsa034500.87231532
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86671455
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86575225
47Lysosome_Homo sapiens_hsa041420.86440102
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86023321
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84715115
50Renal cell carcinoma_Homo sapiens_hsa052110.83324270
51Long-term potentiation_Homo sapiens_hsa047200.82914281
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81859420
53Influenza A_Homo sapiens_hsa051640.81770488
54Other glycan degradation_Homo sapiens_hsa005110.80847847
55Toxoplasmosis_Homo sapiens_hsa051450.80640040
56Hepatitis B_Homo sapiens_hsa051610.80401127
57Complement and coagulation cascades_Homo sapiens_hsa046100.80269293
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79415324
59Apoptosis_Homo sapiens_hsa042100.78371334
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78130876
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.77337217
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76543491
63Insulin resistance_Homo sapiens_hsa049310.75243616
64Platelet activation_Homo sapiens_hsa046110.74626571
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74043155
66Non-small cell lung cancer_Homo sapiens_hsa052230.72777458
67Inositol phosphate metabolism_Homo sapiens_hsa005620.72251782
68Pancreatic secretion_Homo sapiens_hsa049720.71792093
69VEGF signaling pathway_Homo sapiens_hsa043700.71699769
70Amoebiasis_Homo sapiens_hsa051460.71043355
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70464366
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.70069317
73TNF signaling pathway_Homo sapiens_hsa046680.69467054
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68906290
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68886789
76ABC transporters_Homo sapiens_hsa020100.68596957
77Staphylococcus aureus infection_Homo sapiens_hsa051500.66623076
78Hepatitis C_Homo sapiens_hsa051600.66110581
79Pancreatic cancer_Homo sapiens_hsa052120.65941282
80African trypanosomiasis_Homo sapiens_hsa051430.65745494
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65521750
82Fructose and mannose metabolism_Homo sapiens_hsa000510.65342655
83Chronic myeloid leukemia_Homo sapiens_hsa052200.64964033
84Arginine biosynthesis_Homo sapiens_hsa002200.64000501
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63985556
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.61642703
87Allograft rejection_Homo sapiens_hsa053300.59872363
88Epstein-Barr virus infection_Homo sapiens_hsa051690.59236681
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56251092
90Choline metabolism in cancer_Homo sapiens_hsa052310.55654748
91Protein digestion and absorption_Homo sapiens_hsa049740.55294499
92MAPK signaling pathway_Homo sapiens_hsa040100.54700302
93Lysine degradation_Homo sapiens_hsa003100.54581194
94Base excision repair_Homo sapiens_hsa034100.54194080
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53114243
96Viral carcinogenesis_Homo sapiens_hsa052030.50233527
97Thyroid hormone synthesis_Homo sapiens_hsa049180.50021121
98Prion diseases_Homo sapiens_hsa050200.48258778
99Shigellosis_Homo sapiens_hsa051310.47735506
100Systemic lupus erythematosus_Homo sapiens_hsa053220.47681648
101Nitrogen metabolism_Homo sapiens_hsa009100.47260941
102Bladder cancer_Homo sapiens_hsa052190.46995299
103Starch and sucrose metabolism_Homo sapiens_hsa005000.46586209
104Amphetamine addiction_Homo sapiens_hsa050310.46403910
105HIF-1 signaling pathway_Homo sapiens_hsa040660.46004691
106Endometrial cancer_Homo sapiens_hsa052130.44938176
107Type II diabetes mellitus_Homo sapiens_hsa049300.44851624
108Small cell lung cancer_Homo sapiens_hsa052220.43038103
109Sphingolipid metabolism_Homo sapiens_hsa006000.43030272
110HTLV-I infection_Homo sapiens_hsa051660.40983284
111Cocaine addiction_Homo sapiens_hsa050300.40529594
112Viral myocarditis_Homo sapiens_hsa054160.39863493
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37039579
114GnRH signaling pathway_Homo sapiens_hsa049120.36657385
115FoxO signaling pathway_Homo sapiens_hsa040680.35116145
116Estrogen signaling pathway_Homo sapiens_hsa049150.31112303
117Glioma_Homo sapiens_hsa052140.29286126
118Autoimmune thyroid disease_Homo sapiens_hsa053200.28929936
119Prostate cancer_Homo sapiens_hsa052150.28452926
120Prolactin signaling pathway_Homo sapiens_hsa049170.27781490
121Dopaminergic synapse_Homo sapiens_hsa047280.26091871
122Renin secretion_Homo sapiens_hsa049240.25691424
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25684083
124Selenocompound metabolism_Homo sapiens_hsa004500.25621804
125Legionellosis_Homo sapiens_hsa051340.25548954
126MicroRNAs in cancer_Homo sapiens_hsa052060.22679583
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21945606
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20537151
129Insulin secretion_Homo sapiens_hsa049110.19922153
130Glucagon signaling pathway_Homo sapiens_hsa049220.19467117
131Cholinergic synapse_Homo sapiens_hsa047250.19407350
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18777879
133Calcium signaling pathway_Homo sapiens_hsa040200.18682715
134Salmonella infection_Homo sapiens_hsa051320.18140481
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.17536786

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