ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of glucose import in response to insulin stimulus (GO:2001273)	8.38770771
2	complement activation (GO:0006956)	8.22619812
3	negative regulation of glucose import (GO:0046325)	7.46421090
4	positive regulation of respiratory burst (GO:0060267)	6.95902814
5	negative regulation of glucose transport (GO:0010829)	6.56831620
6	glomerular filtration (GO:0003094)	5.95437203
7	protein activation cascade (GO:0072376)	5.95212053
8	regulation of respiratory burst (GO:0060263)	5.51375038
9	renal filtration (GO:0097205)	5.36298392
10	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	5.34912956
11	humoral immune response (GO:0006959)	5.06289281
12	GDP-mannose metabolic process (GO:0019673)	4.92267992
13	interleukin-6-mediated signaling pathway (GO:0070102)	4.87985567
14	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:0002	4.82608584
15	Fc-gamma receptor signaling pathway (GO:0038094)	4.82608584
16	Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	4.82608584
17	Fc receptor mediated stimulatory signaling pathway (GO:0002431)	4.79284771
18	antigen processing and presentation of endogenous antigen (GO:0019883)	4.77527411
19	regulation of cellular extravasation (GO:0002691)	4.75836371
20	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	4.68640668
21	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	4.62443355
22	mannose metabolic process (GO:0006013)	4.62233290
23	NIK/NF-kappaB signaling (GO:0038061)	4.51743553
24	ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	4.15874135
25	antibacterial humoral response (GO:0019731)	4.13860144
26	antimicrobial humoral response (GO:0019730)	4.10523279
27	cellular response to ethanol (GO:0071361)	4.03211558
28	protein maturation by protein folding (GO:0022417)	3.99029057
29	retina homeostasis (GO:0001895)	3.97004423
30	embryonic process involved in female pregnancy (GO:0060136)	3.77842723
31	immunoglobulin mediated immune response (GO:0016064)	3.77326844
32	positive regulation of gamma-delta T cell activation (GO:0046645)	3.70763718
33	ER overload response (GO:0006983)	3.56652464
34	B cell receptor signaling pathway (GO:0050853)	3.52869491
35	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.51272932
36	negative regulation of cell killing (GO:0031342)	3.38747679
37	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.38747679
38	negative regulation of cellular response to insulin stimulus (GO:1900077)	3.38098894
39	signal peptide processing (GO:0006465)	3.37898327
40	immune response-activating cell surface receptor signaling pathway (GO:0002429)	3.34977193
41	regulation of dendritic cell antigen processing and presentation (GO:0002604)	3.34315364
42	regulation of antigen processing and presentation (GO:0002577)	3.31564044
43	regulation of T cell migration (GO:2000404)	3.29539433
44	labyrinthine layer development (GO:0060711)	3.27695688
45	interferon-gamma-mediated signaling pathway (GO:0060333)	3.23886888
46	respiratory burst (GO:0045730)	3.17431574
47	cellular response to type I interferon (GO:0071357)	3.17406324
48	type I interferon signaling pathway (GO:0060337)	3.17406324
49	response to type I interferon (GO:0034340)	3.14083876
50	regulation of B cell proliferation (GO:0030888)	3.07278623
51	post-embryonic morphogenesis (GO:0009886)	3.04635569
52	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.03089361
53	positive regulation of antigen processing and presentation (GO:0002579)	3.02469844
54	germinal center formation (GO:0002467)	3.00082229
55	negative regulation of glycogen biosynthetic process (GO:0045719)	2.97346308
56	nucleotide-sugar biosynthetic process (GO:0009226)	2.95318622
57	B cell mediated immunity (GO:0019724)	2.93706492
58	cellular extravasation (GO:0045123)	2.93517589
59	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.88973265
60	endoplasmic reticulum unfolded protein response (GO:0030968)	2.84659156
61	positive regulation of immunoglobulin production (GO:0002639)	2.84206386
62	positive regulation of phosphatase activity (GO:0010922)	2.81266910
63	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.81061595
64	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.78802698
65	interferon-gamma secretion (GO:0072643)	2.76953086
66	cellular response to unfolded protein (GO:0034620)	2.75790615
67	positive thymic T cell selection (GO:0045059)	2.74623037
68	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	2.72700680
69	regulation of gamma-delta T cell activation (GO:0046643)	2.72086161
70	negative regulation of bone resorption (GO:0045779)	2.69960865
71	regulation of MHC class I biosynthetic process (GO:0045343)	2.69133943
72	detection of bacterium (GO:0016045)	2.68006845
73	positive regulation of B cell differentiation (GO:0045579)	2.67920096
74	detection of other organism (GO:0098543)	2.66381552
75	positive regulation of nuclease activity (GO:0032075)	2.66100300
76	regulation of lymphocyte migration (GO:2000401)	2.63699186
77	positive regulation of T cell migration (GO:2000406)	2.61880387
78	regulation of T cell mediated cytotoxicity (GO:0001914)	2.61184139
79	B cell proliferation (GO:0042100)	2.60939673
80	tyrosine phosphorylation of STAT protein (GO:0007260)	2.60697196
81	regulation of energy homeostasis (GO:2000505)	2.59753493
82	B cell homeostasis (GO:0001782)	2.59698100
83	regulation of B cell receptor signaling pathway (GO:0050855)	2.57919018
84	immune response-activating signal transduction (GO:0002757)	2.57810343
85	regulation of B cell differentiation (GO:0045577)	2.56882062
86	T cell homeostasis (GO:0043029)	2.53910972
87	cellular response to topologically incorrect protein (GO:0035967)	2.53664477
88	ER-nucleus signaling pathway (GO:0006984)	2.52450921
89	activation of immune response (GO:0002253)	2.51675919
90	glycosphingolipid catabolic process (GO:0046479)	2.50881139
91	positive regulation of Rap GTPase activity (GO:0032854)	2.50729290
92	cellular response to interferon-gamma (GO:0071346)	2.50230910
93	positive T cell selection (GO:0043368)	2.47823441
94	detection of external biotic stimulus (GO:0098581)	2.47712353
95	skin morphogenesis (GO:0043589)	2.47234348
96	regulation of nuclease activity (GO:0032069)	2.46716286
97	lymph node development (GO:0048535)	2.46513680
98	natural killer cell activation involved in immune response (GO:0002323)	2.46035018
99	positive regulation of interleukin-1 production (GO:0032732)	2.45881236
100	complement activation, classical pathway (GO:0006958)	10.3888671

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	6.74222548
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.22197165
3	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	4.12970344
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.90712816
5	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.68708557
6	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	3.30402220
7	IRF8_27001747_Chip-Seq_BMDM_Mouse	2.94220698
8	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.78759589
9	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	2.41632759
10	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.31828851
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.20186416
12	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.13448871
13	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.12275422
14	GATA1_22025678_ChIP-Seq_K562_Human	2.09935153
15	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	2.09365273
16	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.08352115
17	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.02721375
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.93199163
19	MYB_26560356_Chip-Seq_TH2_Human	1.88894971
20	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.86723375
21	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.83615031
22	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.82222771
23	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.76904725
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.73557128
25	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.72456885
26	RUNX_20019798_ChIP-Seq_JUKART_Human	1.68573267
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.66429625
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.65846358
29	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.54916831
30	GATA3_27048872_Chip-Seq_THYMUS_Human	1.53416076
31	SPI1_23547873_ChIP-Seq_NB4_Human	1.52851988
32	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.52557653
33	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.52205237
34	CLOCK_20551151_ChIP-Seq_293T_Human	1.46017221
35	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.44268106
36	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.43993647
37	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.43769719
38	GATA3_26560356_Chip-Seq_TH2_Human	1.40874858
39	SCL_19346495_ChIP-Seq_HPC-7_Human	1.40094785
40	MYC_22102868_ChIP-Seq_BL_Human	1.37467466
41	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.35518801
42	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.32610005
43	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.30414187
44	MYB_26560356_Chip-Seq_TH1_Human	1.29578117
45	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.28917986
46	VDR_24763502_ChIP-Seq_THP-1_Human	1.28865793
47	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.28275436
48	VDR_24787735_ChIP-Seq_THP-1_Human	1.22378693
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20394540
50	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.19600578
51	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.19187567
52	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.16263712
53	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.15046457
54	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.13957972
55	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13745758
56	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.12597850
57	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.11358829
58	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.10777325
59	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.08629170
60	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.06655857
61	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.05071255
62	GATA4_25053715_ChIP-Seq_YYC3_Human	1.03780657
63	SPI1_23127762_ChIP-Seq_K562_Human	1.03058270
64	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02344321
65	MAF_26560356_Chip-Seq_TH1_Human	1.02135056
66	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.01935077
67	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.01200446
68	SOX2_20726797_ChIP-Seq_SW620_Human	0.99869391
69	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.98476274
70	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98442330
71	UTX_26944678_Chip-Seq_JUKART_Human	0.98402470
72	CEBPB_22108803_ChIP-Seq_LS180_Human	0.96766226
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96166079
74	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.94810751
75	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.93446774
76	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.93119180
77	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.91853584
78	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90666937
79	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.89870848
80	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.89113660
81	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85490745
82	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.85336076
83	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.84659544
84	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.83878583
85	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.83460706
86	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.83272701
87	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.80239905
88	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.80230008
89	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.79895516
90	STAT1_20625510_ChIP-Seq_HELA_Human	0.76951167
91	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.76466635
92	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.74380613
93	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.72557224
94	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.72244892
95	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.72233501
96	PU_27001747_Chip-Seq_BMDM_Mouse	0.72112377
97	EGR1_19032775_ChIP-ChIP_M12_Human	0.72054316
98	GATA2_19941826_ChIP-Seq_K562_Human	0.71674445
99	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.71216939
100	SMRT_27268052_Chip-Seq_Bcells_Human	0.71199334

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003724_increased_susceptibility_to	3.86314444
2	MP0003303_peritoneal_inflammation	3.63329351
3	MP0010234_abnormal_vibrissa_follicle	3.27945448
4	MP0001835_abnormal_antigen_presentation	3.27875372
5	MP0001800_abnormal_humoral_immune	3.08202528
6	MP0005671_abnormal_response_to	2.92886913
7	MP0005387_immune_system_phenotype	2.78108724
8	MP0001790_abnormal_immune_system	2.78108724
9	MP0003436_decreased_susceptibility_to	2.76409590
10	MP0000685_abnormal_immune_system	2.72905513
11	MP0002148_abnormal_hypersensitivity_rea	2.45566129
12	MP0010155_abnormal_intestine_physiology	2.42547542
13	MP0005000_abnormal_immune_tolerance	2.39806966
14	MP0002452_abnormal_antigen_presenting	2.36478644
15	MP0005025_abnormal_response_to	2.34367206
16	MP0002138_abnormal_hepatobiliary_system	2.28053054
17	MP0002723_abnormal_immune_serum	2.15043690
18	MP0009785_altered_susceptibility_to	2.11606698
19	MP0000015_abnormal_ear_pigmentation	2.05163308
20	MP0001819_abnormal_immune_cell	2.02299904
21	MP0002420_abnormal_adaptive_immunity	2.01897241
22	MP0001873_stomach_inflammation	1.99807886
23	MP0002419_abnormal_innate_immunity	1.97761906
24	MP0003656_abnormal_erythrocyte_physiolo	1.93510731
25	MP0008438_abnormal_cutaneous_collagen	1.91891696
26	MP0001533_abnormal_skeleton_physiology	1.88001530
27	MP0000465_gastrointestinal_hemorrhage	1.84403905
28	MP0005464_abnormal_platelet_physiology	1.84087957
29	MP0002277_abnormal_respiratory_mucosa	1.73712597
30	MP0008260_abnormal_autophagy	1.73394687
31	MP0001845_abnormal_inflammatory_respons	1.72619313
32	MP0003866_abnormal_defecation	1.67515024
33	MP0002254_reproductive_system_inflammat	1.65472857
34	MP0004782_abnormal_surfactant_physiolog	1.64465368
35	MP0003045_fibrosis	1.61813919
36	MP0005166_decreased_susceptibility_to	1.52966278
37	MP0003300_gastrointestinal_ulcer	1.52822234
38	MP0002398_abnormal_bone_marrow	1.50932417
39	MP0005275_abnormal_skin_tensile	1.50791344
40	MP0000716_abnormal_immune_system	1.50581110
41	MP0004264_abnormal_extraembryonic_tissu	1.46318823
42	MP0004947_skin_inflammation	1.43487323
43	MP0003075_altered_response_to	1.38279253
44	MP0005310_abnormal_salivary_gland	1.36448914
45	MP0005023_abnormal_wound_healing	1.32590916
46	MP0004036_abnormal_muscle_relaxation	1.27913696
47	MP0001663_abnormal_digestive_system	1.26918946
48	MP0003763_abnormal_thymus_physiology	1.26146232
49	MP0000689_abnormal_spleen_morphology	1.24775015
50	MP0008004_abnormal_stomach_pH	1.23600659
51	MP0002429_abnormal_blood_cell	1.22248169
52	MP0000604_amyloidosis	1.20262388
53	MP0004858_abnormal_nervous_system	1.20159013
54	MP0005503_abnormal_tendon_morphology	1.19056423
55	MP0002933_joint_inflammation	1.17867981
56	MP0002722_abnormal_immune_system	1.16119244
57	MP0003448_altered_tumor_morphology	1.10744226
58	MP0001986_abnormal_taste_sensitivity	1.08063778
59	MP0006082_CNS_inflammation	1.08055775
60	MP0005397_hematopoietic_system_phenotyp	1.06109963
61	MP0001545_abnormal_hematopoietic_system	1.06109963
62	MP0009764_decreased_sensitivity_to	1.03883252
63	MP0004510_myositis	1.02740873
64	MP0002132_abnormal_respiratory_system	1.01364200
65	MP0002405_respiratory_system_inflammati	1.01305900
66	MP0008469_abnormal_protein_level	0.98528014
67	MP0002166_altered_tumor_susceptibility	0.98209188
68	MP0005085_abnormal_gallbladder_physiolo	0.97699076
69	MP0002136_abnormal_kidney_physiology	0.94676936
70	MP0003795_abnormal_bone_structure	0.94607429
71	MP0003950_abnormal_plasma_membrane	0.94595225
72	MP0003183_abnormal_peptide_metabolism	0.93312066
73	MP0004808_abnormal_hematopoietic_stem	0.92970327
74	MP0002876_abnormal_thyroid_physiology	0.92195753
75	MP0009333_abnormal_splenocyte_physiolog	0.92067414
76	MP0000249_abnormal_blood_vessel	0.91651212
77	MP0005332_abnormal_amino_acid	0.87618258
78	MP0003279_aneurysm	0.87535081
79	MP0005390_skeleton_phenotype	0.86689289
80	MP0001666_abnormal_nutrient_absorption	0.85596025
81	MP0005381_digestive/alimentary_phenotyp	0.85110854
82	MP0006054_spinal_hemorrhage	0.84868746
83	MP0009278_abnormal_bone_marrow	0.84690979
84	MP0000490_abnormal_crypts_of	0.84049616
85	MP0002998_abnormal_bone_remodeling	0.83907596
86	MP0003453_abnormal_keratinocyte_physiol	0.83863913
87	MP0001851_eye_inflammation	0.83842023
88	MP0002896_abnormal_bone_mineralization	0.83840255
89	MP0005165_increased_susceptibility_to	0.82719273
90	MP0000343_altered_response_to	0.82123323
91	MP0001542_abnormal_bone_strength	0.80740856
92	MP0001664_abnormal_digestion	0.80427907
93	MP0003091_abnormal_cell_migration	0.80217637
94	MP0004084_abnormal_cardiac_muscle	0.78146515
95	MP0005257_abnormal_intraocular_pressure	0.77181372
96	MP0003868_abnormal_feces_composition	0.76968625
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.74961169
98	MP0002095_abnormal_skin_pigmentation	0.74877878
99	MP0000681_abnormal_thyroid_gland	0.74647231
100	MP0000858_altered_metastatic_potential	0.74637180

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nonimmune hydrops fetalis (HP:0001790)	6.52496364
2	Agammaglobulinemia (HP:0004432)	5.73447811
3	Prostate neoplasm (HP:0100787)	5.31390010
4	Abnormality of macrophages (HP:0004311)	4.43832435
5	Chronic sinusitis (HP:0011109)	4.22042984
6	Gastrointestinal infarctions (HP:0005244)	4.16330540
7	Systemic lupus erythematosus (HP:0002725)	4.03811353
8	Abnormality of the prostate (HP:0008775)	3.92477369
9	Thrombocytosis (HP:0001894)	3.92229634
10	Cellulitis (HP:0100658)	3.69767815
11	Recurrent bronchitis (HP:0002837)	3.55342646
12	Verrucae (HP:0200043)	3.50835451
13	Papilloma (HP:0012740)	3.50835451
14	Vertebral compression fractures (HP:0002953)	3.35487233
15	Recurrent pneumonia (HP:0006532)	3.31753423
16	Glucose intolerance (HP:0000833)	3.25801083
17	Osteomyelitis (HP:0002754)	3.21142106
18	Nephritis (HP:0000123)	3.20000014
19	Skin rash (HP:0000988)	3.18488491
20	Meningitis (HP:0001287)	3.17937576
21	Malnutrition (HP:0004395)	3.17077381
22	Peritonitis (HP:0002586)	3.15095620
23	Vasculitis (HP:0002633)	3.14311414
24	Glomerulonephritis (HP:0000099)	3.13232934
25	Eczematoid dermatitis (HP:0000976)	3.04392982
26	Abnormality of cells of the lymphoid lineage (HP:0012140)	3.00282201
27	Gingival bleeding (HP:0000225)	2.93601052
28	Hypoplasia of the pons (HP:0012110)	2.90038904
29	Abnormality of liposaccharide metabolism (HP:0010968)	2.88247191
30	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.88247191
31	Abnormality of glycolipid metabolism (HP:0010969)	2.88247191
32	Abnormal glucose tolerance (HP:0001952)	2.82622180
33	Gastrointestinal stroma tumor (HP:0100723)	2.80724320
34	Interstitial pulmonary disease (HP:0006530)	2.79111489
35	Type I transferrin isoform profile (HP:0003642)	2.78905074
36	Spastic paraparesis (HP:0002313)	2.78275566
37	Reduced antithrombin III activity (HP:0001976)	2.74843465
38	IgA deficiency (HP:0002720)	2.67341634
39	Global brain atrophy (HP:0002283)	2.64716494
40	Abnormality of complement system (HP:0005339)	2.64591253
41	Nuclear cataract (HP:0100018)	2.64295488
42	Abnormality of the pons (HP:0007361)	2.63146528
43	Recurrent lower respiratory tract infections (HP:0002783)	2.61403894
44	Hematochezia (HP:0002573)	2.60339319
45	Acute hepatic failure (HP:0006554)	2.60318326
46	Testicular atrophy (HP:0000029)	2.60011155
47	Leukocytosis (HP:0001974)	2.57997707
48	Pulmonary infiltrates (HP:0002113)	2.52667059
49	Stroke (HP:0001297)	2.50988850
50	Inflammation of the large intestine (HP:0002037)	2.50907330
51	Complement deficiency (HP:0004431)	2.50507667
52	Hypokinesia (HP:0002375)	2.47842053
53	Purpura (HP:0000979)	2.46459359
54	Chest pain (HP:0100749)	2.37775465
55	Recurrent viral infections (HP:0004429)	2.36475912
56	Colitis (HP:0002583)	2.34202443
57	Hydroureter (HP:0000072)	2.33445855
58	Recurrent bacterial skin infections (HP:0005406)	2.33076940
59	Abnormality of the intrinsic pathway (HP:0010989)	2.32264275
60	Gastrointestinal inflammation (HP:0004386)	2.31520907
61	Megaloblastic anemia (HP:0001889)	2.27829350
62	Chronic obstructive pulmonary disease (HP:0006510)	2.27485457
63	Obstructive lung disease (HP:0006536)	2.27485457
64	Emphysema (HP:0002097)	2.27197365
65	Chronic otitis media (HP:0000389)	2.26641675
66	Recurrent abscess formation (HP:0002722)	2.24883246
67	Restrictive lung disease (HP:0002091)	2.24282899
68	Sepsis (HP:0100806)	2.24136309
69	Gingivitis (HP:0000230)	2.21721326
70	Curly hair (HP:0002212)	2.21533492
71	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.18448773
72	Abnormality of male internal genitalia (HP:0000022)	2.17652381
73	Abnormality of the pericardium (HP:0001697)	2.15554741
74	Persistence of primary teeth (HP:0006335)	2.15302380
75	Hemoptysis (HP:0002105)	2.14816392
76	Prolonged partial thromboplastin time (HP:0003645)	2.14283523
77	Spontaneous hematomas (HP:0007420)	2.12752377
78	Epistaxis (HP:0000421)	2.11575723
79	Proximal tubulopathy (HP:0000114)	2.10728026
80	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.08987911
81	Follicular hyperkeratosis (HP:0007502)	2.08703667
82	Orchitis (HP:0100796)	2.05388561
83	Cutaneous melanoma (HP:0012056)	2.03148216
84	Abnormality of the nasal mucosa (HP:0000433)	2.02835785
85	Abnormality of the peritoneum (HP:0002585)	2.02504265
86	Myositis (HP:0100614)	2.02194238
87	Bronchitis (HP:0012387)	2.01627233
88	Premature loss of primary teeth (HP:0006323)	1.99761212
89	Hypoalbuminemia (HP:0003073)	1.99723456
90	Abnormal albumin level (HP:0012116)	1.99723456
91	Vacuolated lymphocytes (HP:0001922)	1.97778136
92	Dehydration (HP:0001944)	1.96119497
93	Urticaria (HP:0001025)	1.94800026
94	Lymphopenia (HP:0001888)	1.94047990
95	Decreased circulating renin level (HP:0003351)	1.93637096
96	Abnormality of B cell number (HP:0010975)	1.92203517
97	Hyperactive renin-angiotensin system (HP:0000841)	1.89711230
98	Mediastinal lymphadenopathy (HP:0100721)	1.88932318
99	Apathy (HP:0000741)	1.88402817
100	Hydroxyprolinuria (HP:0003080)	1.86676256

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PKN2	5.53666319
2	CAMKK2	5.18507424
3	BRSK2	4.86323099
4	ERN1	3.79766842
5	FLT3	3.76063726
6	TYK2	3.31111623
7	IRAK4	2.99070480
8	CAMKK1	2.90127577
9	TESK2	2.84355917
10	IRAK1	2.46804019
11	IRAK2	2.24018117
12	MET	2.15855511
13	MAP4K1	2.00312480
14	BRSK1	1.94779017
15	JAK3	1.84855105
16	SIK3	1.73413571
17	AKT3	1.64228078
18	IKBKE	1.62971776
19	MST1R	1.57508309
20	MAP3K14	1.55703031
21	PIK3CG	1.55575936
22	BLK	1.52912443
23	GRK1	1.45523282
24	EIF2AK3	1.43229742
25	ACVR1B	1.38987809
26	TBK1	1.31588299
27	HCK	1.30963380
28	SYK	1.29668862
29	TXK	1.25214257
30	BTK	1.24672111
31	KIT	1.17701595
32	JAK1	1.15081431
33	ITK	1.15044176
34	STK24	1.10950966
35	TEC	1.09972557
36	RIPK4	1.08150560
37	PRPF4B	1.08026853
38	FGFR4	1.07821803
39	JAK2	1.03443632
40	EPHA3	0.87402192
41	PASK	0.87055138
42	CDC42BPA	0.85564211
43	MAP3K13	0.81995989
44	MAPK11	0.81421143
45	RIPK1	0.80121170
46	RET	0.77752663
47	ZAP70	0.76849034
48	LYN	0.76172795
49	MAP3K10	0.69715765
50	IGF1R	0.69375322
51	CSK	0.68630002
52	SIK1	0.68538575
53	MAP3K1	0.66000889
54	MAP3K9	0.65886620
55	FES	0.64281806
56	GRK6	0.64004565
57	MAP3K11	0.63539888
58	PIK3CA	0.61128030
59	MAPKAPK3	0.60468384
60	CSF1R	0.59150742
61	STK38L	0.58185249
62	EPHB1	0.57618874
63	PDGFRA	0.56686105
64	FER	0.52977686
65	MATK	0.52334556
66	PRKAA2	0.50419891
67	IKBKB	0.49923646
68	TLK1	0.46376190
69	FGFR3	0.46143156
70	SIK2	0.42566234
71	LMTK2	0.42400213
72	EPHA2	0.40123728
73	MAPKAPK5	0.39371584
74	PRKG2	0.38351347
75	PRKCQ	0.36982071
76	ABL1	0.35386189
77	TAOK1	0.35357186
78	LCK	0.31988335
79	PDK1	0.31933639
80	MAP3K3	0.31732778
81	STK11	0.31349514
82	GRK5	0.31258236
83	MAP3K12	0.28594227
84	TAOK2	0.28407599
85	TGFBR1	0.28050913
86	MAP3K6	0.26576750
87	BMPR2	0.25633197
88	TGFBR2	0.24049238
89	MAP2K3	0.23638480
90	CAMK2B	0.22079516
91	MAPK7	0.21950890
92	FYN	0.20981979
93	PAK3	0.19641767
94	DDR2	0.18299816
95	ABL2	0.17049664
96	MAPK3	0.16758455
97	NLK	0.16582267
98	HIPK2	0.14523143
99	MARK3	0.14363948
100	CDK6	0.13912566

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.78084799
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.68673200
3	Staphylococcus aureus infection_Homo sapiens_hsa05150	3.55218864
4	Allograft rejection_Homo sapiens_hsa05330	3.15080904
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.07849657
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.86973650
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.58268677
8	Leishmaniasis_Homo sapiens_hsa05140	2.40261664
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.36222474
10	B cell receptor signaling pathway_Homo sapiens_hsa04662	2.33489121
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.27098320
12	Protein export_Homo sapiens_hsa03060	2.16907620
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.10130036
14	Osteoclast differentiation_Homo sapiens_hsa04380	1.92925270
15	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.83359199
16	Viral myocarditis_Homo sapiens_hsa05416	1.78107298
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.70429825
18	Sulfur metabolism_Homo sapiens_hsa00920	1.65064536
19	Toxoplasmosis_Homo sapiens_hsa05145	1.62513309
20	Other glycan degradation_Homo sapiens_hsa00511	1.61325417
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58898159
22	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.40454637
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.38941487
24	Tuberculosis_Homo sapiens_hsa05152	1.33842309
25	Influenza A_Homo sapiens_hsa05164	1.31245842
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.26203801
27	Chemokine signaling pathway_Homo sapiens_hsa04062	1.16335780
28	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.15477725
29	Pertussis_Homo sapiens_hsa05133	1.13474570
30	TNF signaling pathway_Homo sapiens_hsa04668	1.09347785
31	Malaria_Homo sapiens_hsa05144	1.06563625
32	Herpes simplex infection_Homo sapiens_hsa05168	1.05450248
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.02713515
34	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.00314995
35	Phagosome_Homo sapiens_hsa04145	0.99800686
36	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99489653
37	Complement and coagulation cascades_Homo sapiens_hsa04610	0.98552629
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.97847514
39	Regulation of autophagy_Homo sapiens_hsa04140	0.96711064
40	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.93965732
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90490810
42	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.81039353
43	Hepatitis C_Homo sapiens_hsa05160	0.80743730
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.75214900
45	Caffeine metabolism_Homo sapiens_hsa00232	0.74566730
46	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.73800883
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73374502
48	Lysosome_Homo sapiens_hsa04142	0.73317011
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72984724
50	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.71891622
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.71456149
52	Measles_Homo sapiens_hsa05162	0.71437201
53	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.70140695
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.68267092
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.68073678
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66375268
57	Protein digestion and absorption_Homo sapiens_hsa04974	0.65222704
58	African trypanosomiasis_Homo sapiens_hsa05143	0.63066316
59	Acute myeloid leukemia_Homo sapiens_hsa05221	0.62070265
60	Renal cell carcinoma_Homo sapiens_hsa05211	0.59627067
61	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.59372525
62	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.57265832
63	Pancreatic secretion_Homo sapiens_hsa04972	0.56146559
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56012677
65	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.54276844
66	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.53911007
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53910168
68	Amoebiasis_Homo sapiens_hsa05146	0.51968929
69	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.50906288
70	Legionellosis_Homo sapiens_hsa05134	0.50741945
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.50167787
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.49582604
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48086254
74	Prolactin signaling pathway_Homo sapiens_hsa04917	0.47685589
75	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.46534178
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45542252
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.45527901
78	Apoptosis_Homo sapiens_hsa04210	0.43907186
79	Hepatitis B_Homo sapiens_hsa05161	0.43905012
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41504707
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41427205
82	PPAR signaling pathway_Homo sapiens_hsa03320	0.40309430
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.39101705
84	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.38669459
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.38016558
86	HTLV-I infection_Homo sapiens_hsa05166	0.34659922
87	Olfactory transduction_Homo sapiens_hsa04740	0.32784954
88	Mineral absorption_Homo sapiens_hsa04978	0.32471268
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30304754
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30209636
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29862765
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.29484785
93	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.28418526
94	Thyroid cancer_Homo sapiens_hsa05216	0.27776112
95	FoxO signaling pathway_Homo sapiens_hsa04068	0.26886044
96	Platelet activation_Homo sapiens_hsa04611	0.26718214
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26687943
98	Pancreatic cancer_Homo sapiens_hsa05212	0.26619676
99	Histidine metabolism_Homo sapiens_hsa00340	0.26370874
100	VEGF signaling pathway_Homo sapiens_hsa04370	0.26233693

IGHV3-30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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