IGHV4-34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)9.37357058
2protein activation cascade (GO:0072376)6.85363562
3positive regulation of respiratory burst (GO:0060267)6.75778080
4glomerular filtration (GO:0003094)6.23138768
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07064037
6Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)6.05867402
7immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00026.05867402
8Fc-gamma receptor signaling pathway (GO:0038094)6.05867402
9Fc receptor mediated stimulatory signaling pathway (GO:0002431)6.02824522
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.02394728
11antigen processing and presentation of endogenous antigen (GO:0019883)5.91224325
12renal filtration (GO:0097205)5.60789614
13humoral immune response (GO:0006959)5.34239905
14regulation of respiratory burst (GO:0060263)4.51085281
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40961381
16germinal center formation (GO:0002467)4.39324001
17immunoglobulin mediated immune response (GO:0016064)4.37932704
18negative regulation of cell killing (GO:0031342)4.34089908
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34089908
20antibacterial humoral response (GO:0019731)4.30105847
21antimicrobial humoral response (GO:0019730)4.27244472
22positive regulation of gamma-delta T cell activation (GO:0046645)4.04071014
23retina homeostasis (GO:0001895)4.02381016
24interferon-gamma-mediated signaling pathway (GO:0060333)4.00688268
25immune response-activating cell surface receptor signaling pathway (GO:0002429)3.99614562
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.98165741
27detection of other organism (GO:0098543)3.93874603
28detection of bacterium (GO:0016045)3.93584933
29type I interferon signaling pathway (GO:0060337)3.76600696
30cellular response to type I interferon (GO:0071357)3.76600696
31response to type I interferon (GO:0034340)3.73181346
32regulation of antigen processing and presentation (GO:0002577)3.57042790
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.52718275
34regulation of cellular extravasation (GO:0002691)3.44045129
35B cell mediated immunity (GO:0019724)3.39728824
36positive regulation of antigen processing and presentation (GO:0002579)3.27417635
37regulation of B cell receptor signaling pathway (GO:0050855)3.26857011
38chronic inflammatory response (GO:0002544)3.26279870
39cellular response to interferon-gamma (GO:0071346)3.23511193
40B cell receptor signaling pathway (GO:0050853)3.16868450
41detection of external biotic stimulus (GO:0098581)3.09406899
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07914596
43immune response-activating signal transduction (GO:0002757)3.05718980
44response to interferon-gamma (GO:0034341)3.04461214
45response to interleukin-15 (GO:0070672)3.03482342
46myeloid dendritic cell differentiation (GO:0043011)3.03338858
47T-helper 1 type immune response (GO:0042088)3.01990644
48activation of immune response (GO:0002253)2.96278107
49surfactant homeostasis (GO:0043129)2.94191713
50regulation of T cell tolerance induction (GO:0002664)2.91226892
51regulation of gamma-delta T cell activation (GO:0046643)2.89967879
52production of molecular mediator of immune response (GO:0002440)2.89282721
53regulation of integrin activation (GO:0033623)2.83137355
54dendritic cell chemotaxis (GO:0002407)2.82976998
55cellular extravasation (GO:0045123)2.82516004
56modulation by symbiont of host defense response (GO:0052031)2.81726004
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81726004
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81726004
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.81726004
60modulation by symbiont of host immune response (GO:0052553)2.81726004
61positive regulation by symbiont of host defense response (GO:0052509)2.81726004
62regulation of type I interferon-mediated signaling pathway (GO:0060338)2.80436165
63NIK/NF-kappaB signaling (GO:0038061)2.79252128
64myeloid dendritic cell activation (GO:0001773)2.77380706
65respiratory burst (GO:0045730)2.76692342
66positive regulation of type 2 immune response (GO:0002830)2.73860270
67wound healing, spreading of epidermal cells (GO:0035313)2.73271696
68production of molecular mediator involved in inflammatory response (GO:0002532)2.73089887
69adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.73042365
70negative regulation of humoral immune response (GO:0002921)2.73028477
71negative regulation of complement activation (GO:0045916)2.71544858
72leukocyte aggregation (GO:0070486)2.67944899
73positive thymic T cell selection (GO:0045059)2.67886089
74regulation of tolerance induction (GO:0002643)2.67631640
75macrophage activation involved in immune response (GO:0002281)2.63400606
76detection of biotic stimulus (GO:0009595)2.61711556
77regulation of regulatory T cell differentiation (GO:0045589)2.61558071
78lymphocyte chemotaxis (GO:0048247)2.61534254
79interferon-gamma secretion (GO:0072643)2.60564456
80negative regulation of interleukin-12 production (GO:0032695)2.59300758
81positive regulation of B cell differentiation (GO:0045579)2.58840729
82negative regulation of lymphocyte mediated immunity (GO:0002707)2.58700594
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.57559617
84regulation of gamma-delta T cell differentiation (GO:0045586)2.56623363
85T cell costimulation (GO:0031295)2.55717703
86lymphocyte costimulation (GO:0031294)2.52065452
87defense response to protozoan (GO:0042832)2.51494412
88adaptive immune response (GO:0002250)2.51381547
89dendritic cell migration (GO:0036336)2.51168611
90negative regulation of leukocyte mediated immunity (GO:0002704)2.49942635
91negative thymic T cell selection (GO:0045060)2.49655213
92antigen processing and presentation via MHC class Ib (GO:0002475)2.48772053
93negative regulation of myotube differentiation (GO:0010832)2.48745295
94cellular response to interleukin-15 (GO:0071350)2.48139188
95neutrophil activation involved in immune response (GO:0002283)2.47721198
96regulation of T-helper 1 cell differentiation (GO:0045625)2.47086239
97regulation of glucose import in response to insulin stimulus (GO:2001273)2.46895203
98positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.46456249
99immune response-regulating cell surface receptor signaling pathway (GO:0002768)2.45040395
100complement activation, classical pathway (GO:0006958)11.8117561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.40569901
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.96065760
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.91945579
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.07270628
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.69993056
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.36329096
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.28216345
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.75047380
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70086299
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67578970
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61808583
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60728498
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59205474
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41859803
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29379001
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28612552
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21903633
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12416147
19RUNX_20019798_ChIP-Seq_JUKART_Human2.11225644
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10696839
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.09353882
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02543102
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.99705713
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.99241862
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98877887
26MYB_26560356_Chip-Seq_TH2_Human1.91739186
27MYC_22102868_ChIP-Seq_BL_Human1.89095928
28VDR_24763502_ChIP-Seq_THP-1_Human1.73665240
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70223673
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68217586
31MAF_26560356_Chip-Seq_TH1_Human1.67628560
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62874683
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61577168
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57773294
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55207348
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54556525
37SPI1_23547873_ChIP-Seq_NB4_Human1.53861187
38MYB_26560356_Chip-Seq_TH1_Human1.53512670
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51942932
40SPI1_23127762_ChIP-Seq_K562_Human1.47583051
41VDR_21846776_ChIP-Seq_THP-1_Human1.46598664
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.44278183
43CLOCK_20551151_ChIP-Seq_293T_Human1.40090688
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39398497
45UTX_26944678_Chip-Seq_JUKART_Human1.35616037
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30685428
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29238475
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.28052113
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27133579
50VDR_24787735_ChIP-Seq_THP-1_Human1.26136986
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25336764
52TCF7_22412390_ChIP-Seq_EML_Mouse1.24532320
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24141876
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21456037
55LXR_22292898_ChIP-Seq_THP-1_Human1.20581990
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20501076
57GATA3_27048872_Chip-Seq_THYMUS_Human1.19792264
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19681777
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.18017945
60SCL_19346495_ChIP-Seq_HPC-7_Human1.18006805
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16986274
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.12499747
63SOX2_20726797_ChIP-Seq_SW620_Human1.12014846
64EGR1_19032775_ChIP-ChIP_M12_Human1.08280758
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07830396
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.06811542
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05755512
68GATA1_19941826_ChIP-Seq_K562_Human1.03875575
69GATA1_22025678_ChIP-Seq_K562_Human1.03464873
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97381837
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94789464
72PU_27001747_Chip-Seq_BMDM_Mouse0.94281217
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94146739
74GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93909615
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92501396
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91910181
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90386289
78P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90122129
79GATA1_19941827_ChIP-Seq_MEL_Mouse0.89516214
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88476903
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88352509
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88175963
83GATA3_26560356_Chip-Seq_TH2_Human0.84717601
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84435658
85GATA4_25053715_ChIP-Seq_YYC3_Human0.84022597
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84011431
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83478783
88MAF_26560356_Chip-Seq_TH2_Human0.82557159
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81127656
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81127656
91LXR_22158963_ChIP-Seq_LIVER_Mouse0.80948103
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80816375
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80004965
94GATA2_19941826_ChIP-Seq_K562_Human0.79681322
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79440332
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78136620
97ESR2_21235772_ChIP-Seq_MCF-7_Human0.76053807
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75604997
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74920791
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74184178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.75543662
2MP0003303_peritoneal_inflammation3.76070626
3MP0001835_abnormal_antigen_presentation3.67621100
4MP0003436_decreased_susceptibility_to3.41316221
5MP0001790_abnormal_immune_system3.25234696
6MP0005387_immune_system_phenotype3.25234696
7MP0000685_abnormal_immune_system3.00701717
8MP0001800_abnormal_humoral_immune2.97816539
9MP0005025_abnormal_response_to2.63207488
10MP0005671_abnormal_response_to2.61657790
11MP0005000_abnormal_immune_tolerance2.59271223
12MP0010155_abnormal_intestine_physiology2.52907751
13MP0005275_abnormal_skin_tensile2.47882412
14MP0009785_altered_susceptibility_to2.41168775
15MP0002452_abnormal_antigen_presenting2.36152244
16MP0003300_gastrointestinal_ulcer2.36059882
17MP0002148_abnormal_hypersensitivity_rea2.28484345
18MP0002723_abnormal_immune_serum2.22068643
19MP0002419_abnormal_innate_immunity2.16110920
20MP0002420_abnormal_adaptive_immunity2.11921640
21MP0001533_abnormal_skeleton_physiology2.11315290
22MP0001819_abnormal_immune_cell2.11173687
23MP0008438_abnormal_cutaneous_collagen2.07564299
24MP0000465_gastrointestinal_hemorrhage2.02698332
25MP0005166_decreased_susceptibility_to2.00537860
26MP0010234_abnormal_vibrissa_follicle1.96795052
27MP0003763_abnormal_thymus_physiology1.89655388
28MP0004947_skin_inflammation1.85468304
29MP0001845_abnormal_inflammatory_respons1.74170885
30MP0004264_abnormal_extraembryonic_tissu1.71700100
31MP0006082_CNS_inflammation1.69665150
32MP0005503_abnormal_tendon_morphology1.69579311
33MP0002166_altered_tumor_susceptibility1.61719358
34MP0002138_abnormal_hepatobiliary_system1.61692155
35MP0003866_abnormal_defecation1.59322486
36MP0003448_altered_tumor_morphology1.57191890
37MP0000716_abnormal_immune_system1.56184049
38MP0003279_aneurysm1.56078093
39MP0002398_abnormal_bone_marrow1.53134654
40MP0004782_abnormal_surfactant_physiolog1.51722246
41MP0005023_abnormal_wound_healing1.49145062
42MP0002405_respiratory_system_inflammati1.46068914
43MP0001873_stomach_inflammation1.45369980
44MP0005464_abnormal_platelet_physiology1.42585313
45MP0009333_abnormal_splenocyte_physiolog1.41449683
46MP0000343_altered_response_to1.37405476
47MP0008004_abnormal_stomach_pH1.37330817
48MP0003075_altered_response_to1.34945322
49MP0010352_gastrointestinal_tract_polyps1.34716964
50MP0005310_abnormal_salivary_gland1.34104195
51MP0003191_abnormal_cellular_cholesterol1.31800167
52MP0000858_altered_metastatic_potential1.26576149
53MP0003045_fibrosis1.23590104
54MP0002429_abnormal_blood_cell1.23509880
55MP0002006_tumorigenesis1.22679960
56MP0002933_joint_inflammation1.21160802
57MP0001851_eye_inflammation1.18797123
58MP0002722_abnormal_immune_system1.18212252
59MP0000689_abnormal_spleen_morphology1.17531604
60MP0005164_abnormal_response_to1.14312987
61MP0003828_pulmonary_edema1.13842194
62MP0005390_skeleton_phenotype1.13664101
63MP0002998_abnormal_bone_remodeling1.13288654
64MP0004858_abnormal_nervous_system1.13129784
65MP0008469_abnormal_protein_level1.12762362
66MP0000604_amyloidosis1.08635551
67MP0003183_abnormal_peptide_metabolism1.08043700
68MP0001663_abnormal_digestive_system1.06357184
69MP0009764_decreased_sensitivity_to1.04295601
70MP0003566_abnormal_cell_adhesion1.01054899
71MP0008260_abnormal_autophagy0.99654211
72MP0003453_abnormal_keratinocyte_physiol0.98467034
73MP0002277_abnormal_respiratory_mucosa0.95531546
74MP0004510_myositis0.92367760
75MP0000249_abnormal_blood_vessel0.90331611
76MP0005388_respiratory_system_phenotype0.89261340
77MP0002133_abnormal_respiratory_system0.89261340
78MP0003091_abnormal_cell_migration0.88182627
79MP0009278_abnormal_bone_marrow0.84425662
80MP0001879_abnormal_lymphatic_vessel0.83727878
81MP0000703_abnormal_thymus_morphology0.81658835
82MP0002396_abnormal_hematopoietic_system0.80077036
83MP0003795_abnormal_bone_structure0.79536060
84MP0010678_abnormal_skin_adnexa0.78225455
85MP0001958_emphysema0.77659816
86MP0000477_abnormal_intestine_morphology0.76805246
87MP0005165_increased_susceptibility_to0.76522446
88MP0001986_abnormal_taste_sensitivity0.75731095
89MP0000490_abnormal_crypts_of0.75678343
90MP0002060_abnormal_skin_morphology0.75613711
91MP0009840_abnormal_foam_cell0.72303554
92MP0005381_digestive/alimentary_phenotyp0.72269807
93MP0001853_heart_inflammation0.72248228
94MP0003329_amyloid_beta_deposits0.69820266
95MP0001216_abnormal_epidermal_layer0.68583453
96MP0002796_impaired_skin_barrier0.67754927
97MP0009763_increased_sensitivity_to0.67272619
98MP0008874_decreased_physiological_sensi0.67017906
99MP0000681_abnormal_thyroid_gland0.66896435
100MP0002877_abnormal_melanocyte_morpholog0.65497161

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.64937929
2Eczematoid dermatitis (HP:0000976)4.76399362
3Agammaglobulinemia (HP:0004432)4.59927190
4Recurrent bronchitis (HP:0002837)4.24841047
5Gastrointestinal stroma tumor (HP:0100723)3.86749323
6Cellulitis (HP:0100658)3.79511668
7Meningitis (HP:0001287)3.71625096
8Abnormality of complement system (HP:0005339)3.65905615
9Recurrent bacterial skin infections (HP:0005406)3.63416928
10Colitis (HP:0002583)3.57035726
11Gastrointestinal infarctions (HP:0005244)3.54686422
12Premature loss of primary teeth (HP:0006323)3.54325528
13Spontaneous hematomas (HP:0007420)3.50736520
14Recurrent abscess formation (HP:0002722)3.48709217
15Glomerulonephritis (HP:0000099)3.44386857
16Malnutrition (HP:0004395)3.31954855
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.30352782
18Complement deficiency (HP:0004431)3.30326198
19Osteomyelitis (HP:0002754)3.29791819
20* Vasculitis (HP:0002633)3.25829248
21Inflammation of the large intestine (HP:0002037)3.25209170
22Alopecia of scalp (HP:0002293)3.20661491
23Urticaria (HP:0001025)3.20049081
24Abnormality of B cell number (HP:0010975)3.14836475
25Gastrointestinal inflammation (HP:0004386)3.11267635
26* Abnormality of macrophages (HP:0004311)3.05135187
27Recurrent viral infections (HP:0004429)3.05038969
28Gingivitis (HP:0000230)3.03591099
29Myositis (HP:0100614)3.03201144
30Recurrent sinusitis (HP:0011108)2.99674618
31Increased IgE level (HP:0003212)2.99230916
32Nephritis (HP:0000123)2.95243176
33Orchitis (HP:0100796)2.95017359
34Recurrent gram-negative bacterial infections (HP:0005420)2.85416383
35Mediastinal lymphadenopathy (HP:0100721)2.82902703
36Hemoptysis (HP:0002105)2.77913401
37Chronic obstructive pulmonary disease (HP:0006510)2.77240358
38Obstructive lung disease (HP:0006536)2.77240358
39Chronic otitis media (HP:0000389)2.73741954
40Xerostomia (HP:0000217)2.73214200
41Elevated erythrocyte sedimentation rate (HP:0003565)2.71819727
42B lymphocytopenia (HP:0010976)2.70087089
43Emphysema (HP:0002097)2.60652996
44Retrobulbar optic neuritis (HP:0100654)2.59848506
45Optic neuritis (HP:0100653)2.59848506
46Recurrent pneumonia (HP:0006532)2.59532232
47Metaphyseal cupping (HP:0003021)2.58395528
48Recurrent fungal infections (HP:0002841)2.58105853
49Pulmonary infiltrates (HP:0002113)2.55099050
50* Skin rash (HP:0000988)2.54458705
51Recurrent skin infections (HP:0001581)2.53553467
52Abnormality of the nasal mucosa (HP:0000433)2.49698627
53Verrucae (HP:0200043)2.49240224
54Papilloma (HP:0012740)2.49240224
55Thick nail (HP:0001805)2.47945476
56Bronchitis (HP:0012387)2.47889240
57Recurrent lower respiratory tract infections (HP:0002783)2.46879473
58Skin ulcer (HP:0200042)2.46173122
59Abnormal hair laboratory examination (HP:0003328)2.44070908
60Chronic diarrhea (HP:0002028)2.37861383
61Fragile skin (HP:0001030)2.37321664
62Recurrent cutaneous fungal infections (HP:0011370)2.34474192
63Chronic mucocutaneous candidiasis (HP:0002728)2.34474192
64* Abnormality of cells of the lymphoid lineage (HP:0012140)2.33345956
65Lymphopenia (HP:0001888)2.32800033
66Purpura (HP:0000979)2.32146415
67Abnormality of T cell number (HP:0011839)2.28533336
68Sepsis (HP:0100806)2.26604543
69Chest pain (HP:0100749)2.25681655
70Hypergammaglobulinemia (HP:0010702)2.25042768
71Interstitial pulmonary disease (HP:0006530)2.24438049
72Ankyloglossia (HP:0010296)2.24224131
73Periodontitis (HP:0000704)2.23931620
74Atrophic scars (HP:0001075)2.22315740
75Restrictive lung disease (HP:0002091)2.21385635
76Pustule (HP:0200039)2.21372286
77Peritonitis (HP:0002586)2.21086116
78Increased IgM level (HP:0003496)2.19408294
79Autoimmune hemolytic anemia (HP:0001890)2.18469369
80IgM deficiency (HP:0002850)2.17786594
81Keratoconjunctivitis sicca (HP:0001097)2.17489036
82Abnormality of the peritoneum (HP:0002585)2.14414068
83Abnormality of T cell physiology (HP:0011840)2.13783384
84Gingival bleeding (HP:0000225)2.12073245
85Panhypogammaglobulinemia (HP:0003139)2.11922884
86Encephalitis (HP:0002383)2.10993949
87Abnormality of T cells (HP:0002843)2.09206457
88Right ventricular cardiomyopathy (HP:0011663)2.08071383
89Aortic dissection (HP:0002647)2.07941392
90T lymphocytopenia (HP:0005403)2.07363758
91Pili torti (HP:0003777)2.07347744
92IgA deficiency (HP:0002720)2.04908391
93Autoimmune thrombocytopenia (HP:0001973)2.04852807
94Abnormality of the pleura (HP:0002103)2.03171627
95Abnormality of primary teeth (HP:0006481)2.01729325
96Recurrent otitis media (HP:0000403)2.01387148
97Ridged nail (HP:0001807)1.99906388
98Granulocytopenia (HP:0001913)1.97204791
99Erythema (HP:0010783)1.96116560
100Nasal polyposis (HP:0100582)1.95323625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.68919665
2TYK23.61431465
3MAP4K13.27716551
4BLK3.04857983
5FGFR43.03138715
6RIPK42.91482406
7PRPF4B2.63069217
8JAK12.32900226
9MST1R2.32591600
10EPHA32.24040675
11MAP3K142.15040360
12JAK32.14169256
13IRAK42.09343571
14EPHB12.08685748
15KIT2.05450752
16IKBKE1.89615067
17CDC42BPA1.86253130
18FES1.86130204
19CSK1.82261092
20FGFR31.78574148
21MAP3K101.74451087
22RIPK11.69388492
23ZAP701.64336231
24SIK31.63500905
25MAP3K131.63323117
26TESK21.57618345
27GRK61.52902575
28TGFBR11.50829406
29TXK1.50520387
30JAK21.46220834
31SYK1.46015526
32TBK11.42416757
33LYN1.41309985
34PDGFRA1.37313441
35STK241.33765984
36BTK1.28228552
37MAP3K11.18190265
38SMG11.15558486
39IRAK11.13743354
40HCK1.12004871
41PIK3CA1.10034117
42CSF1R1.02381271
43NLK1.00707786
44YES10.90011891
45MATK0.89877977
46BMPR20.89686986
47IKBKB0.88879697
48TGFBR20.87969178
49PKN20.87764543
50MAP2K30.84806128
51MAP3K30.84556424
52MAPK70.84090280
53LCK0.84087164
54FER0.82776339
55FGR0.80678207
56DDR20.75133520
57ITK0.74423184
58HIPK20.69297505
59RET0.69082311
60MET0.68509493
61PDGFRB0.63234830
62TAOK10.62933926
63KSR20.61498029
64FYN0.61063524
65TNK20.60567853
66LRRK20.56304749
67CDK60.56228507
68PTK60.56039344
69TEC0.51709937
70EIF2AK30.51426645
71NEK90.50406681
72TAOK30.50193242
73PDPK10.48965257
74MAPK110.47670467
75PDK10.46700736
76GRK50.44243058
77TRIB30.43796248
78MAP3K60.41762029
79MAPKAPK20.41172353
80PRKCQ0.40494684
81ABL10.38854291
82MAPK120.36551049
83GRK10.33452938
84PRKCD0.33050002
85MYLK0.33009820
86IGF1R0.32229361
87PRKG20.31705059
88DMPK0.29584309
89ALK0.29225854
90PAK40.29145825
91SIK20.28941095
92EPHA20.28524201
93CLK10.27714475
94MAPK40.27401160
95SIK10.27391327
96IRAK30.27194356
97TAOK20.25866199
98MAP3K20.25736101
99FLT30.25073642
100INSR0.24963096

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.02467867
2Asthma_Homo sapiens_hsa053103.64873136
3Allograft rejection_Homo sapiens_hsa053303.47506300
4Autoimmune thyroid disease_Homo sapiens_hsa053203.33545765
5Graft-versus-host disease_Homo sapiens_hsa053323.22203152
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.08357946
7Leishmaniasis_Homo sapiens_hsa051402.89773895
8Type I diabetes mellitus_Homo sapiens_hsa049402.64610104
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47494720
10Antigen processing and presentation_Homo sapiens_hsa046122.38880250
11Primary immunodeficiency_Homo sapiens_hsa053402.30616618
12Viral myocarditis_Homo sapiens_hsa054162.20812876
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93926703
14Osteoclast differentiation_Homo sapiens_hsa043801.89246829
15B cell receptor signaling pathway_Homo sapiens_hsa046621.82116994
16Hematopoietic cell lineage_Homo sapiens_hsa046401.80811897
17Toxoplasmosis_Homo sapiens_hsa051451.79636534
18Systemic lupus erythematosus_Homo sapiens_hsa053221.79513940
19Rheumatoid arthritis_Homo sapiens_hsa053231.59769285
20Influenza A_Homo sapiens_hsa051641.59429091
21Tuberculosis_Homo sapiens_hsa051521.59378088
22Pertussis_Homo sapiens_hsa051331.57400612
23Malaria_Homo sapiens_hsa051441.55075935
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.45449836
25Herpes simplex infection_Homo sapiens_hsa051681.32743586
26Chemokine signaling pathway_Homo sapiens_hsa040621.28258189
27Phagosome_Homo sapiens_hsa041451.27436078
28Measles_Homo sapiens_hsa051621.25105685
29Complement and coagulation cascades_Homo sapiens_hsa046101.24610212
30TNF signaling pathway_Homo sapiens_hsa046681.20092392
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19871438
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16971443
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13075496
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06531347
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04664731
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.03292827
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.02206140
38African trypanosomiasis_Homo sapiens_hsa051431.00313182
39Hepatitis C_Homo sapiens_hsa051600.97569574
40Other glycan degradation_Homo sapiens_hsa005110.96026120
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89393893
42Acute myeloid leukemia_Homo sapiens_hsa052210.83244443
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80995126
44Amoebiasis_Homo sapiens_hsa051460.80091041
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78532478
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73256643
47T cell receptor signaling pathway_Homo sapiens_hsa046600.70741515
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70436169
49Pancreatic cancer_Homo sapiens_hsa052120.68186783
50Hepatitis B_Homo sapiens_hsa051610.65367705
51Apoptosis_Homo sapiens_hsa042100.64393045
52HTLV-I infection_Homo sapiens_hsa051660.64347468
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63833990
54Legionellosis_Homo sapiens_hsa051340.63537651
55Platelet activation_Homo sapiens_hsa046110.63243669
56Fructose and mannose metabolism_Homo sapiens_hsa000510.60418886
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.58192407
58Protein digestion and absorption_Homo sapiens_hsa049740.57090315
59Renal cell carcinoma_Homo sapiens_hsa052110.54029155
60Epstein-Barr virus infection_Homo sapiens_hsa051690.53593671
61Salmonella infection_Homo sapiens_hsa051320.53360781
62Viral carcinogenesis_Homo sapiens_hsa052030.53121214
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52516118
64Prolactin signaling pathway_Homo sapiens_hsa049170.52283772
65Renin-angiotensin system_Homo sapiens_hsa046140.51471084
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50791371
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.50184469
68Chronic myeloid leukemia_Homo sapiens_hsa052200.50099892
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48853909
70HIF-1 signaling pathway_Homo sapiens_hsa040660.48277118
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48121057
72Lysosome_Homo sapiens_hsa041420.47130353
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46940677
74Arginine biosynthesis_Homo sapiens_hsa002200.43528114
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42346642
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41741106
77VEGF signaling pathway_Homo sapiens_hsa043700.40146467
78Shigellosis_Homo sapiens_hsa051310.38765427
79Prion diseases_Homo sapiens_hsa050200.37513002
80Sulfur metabolism_Homo sapiens_hsa009200.36333515
81Small cell lung cancer_Homo sapiens_hsa052220.36256419
82Starch and sucrose metabolism_Homo sapiens_hsa005000.36084442
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34621529
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32974812
85Arachidonic acid metabolism_Homo sapiens_hsa005900.32783658
86Dorso-ventral axis formation_Homo sapiens_hsa043200.31456365
87Non-small cell lung cancer_Homo sapiens_hsa052230.31064408
88Pancreatic secretion_Homo sapiens_hsa049720.29886657
89Notch signaling pathway_Homo sapiens_hsa043300.28985147
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.28220740
91Galactose metabolism_Homo sapiens_hsa000520.27061405
92Alcoholism_Homo sapiens_hsa050340.27013045
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25387796
94GnRH signaling pathway_Homo sapiens_hsa049120.24449675
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23384251
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.22869174
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22174562
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22043805
99Endocytosis_Homo sapiens_hsa041440.21589879
100Choline metabolism in cancer_Homo sapiens_hsa052310.20618714

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