IGHV4-39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)8.35298419
2positive regulation of respiratory burst (GO:0060267)8.11890959
3glomerular filtration (GO:0003094)7.11070333
4renal filtration (GO:0097205)6.42392082
5protein activation cascade (GO:0072376)6.14829789
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.80329713
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.76886748
8antigen processing and presentation of endogenous antigen (GO:0019883)5.54569716
9regulation of respiratory burst (GO:0060263)5.38009641
10Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.18586626
11immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.18586626
12Fc-gamma receptor signaling pathway (GO:0038094)5.18586626
13Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.15812936
14humoral immune response (GO:0006959)4.94101929
15antibacterial humoral response (GO:0019731)4.77984350
16antimicrobial humoral response (GO:0019730)4.76381722
17regulation of dendritic cell antigen processing and presentation (GO:0002604)4.23448483
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.09064562
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.07576313
20immunoglobulin mediated immune response (GO:0016064)3.96683624
21retina homeostasis (GO:0001895)3.96298616
22regulation of antigen processing and presentation (GO:0002577)3.91671921
23regulation of cellular extravasation (GO:0002691)3.88518008
24detection of bacterium (GO:0016045)3.84685670
25interferon-gamma-mediated signaling pathway (GO:0060333)3.81904997
26detection of other organism (GO:0098543)3.77569226
27cellular response to type I interferon (GO:0071357)3.71110856
28type I interferon signaling pathway (GO:0060337)3.71110856
29response to type I interferon (GO:0034340)3.70024108
30germinal center formation (GO:0002467)3.65736396
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65058769
32negative regulation of cell killing (GO:0031342)3.65058769
33positive regulation of antigen processing and presentation (GO:0002579)3.62355348
34positive regulation of gamma-delta T cell activation (GO:0046645)3.54385475
35immune response-activating cell surface receptor signaling pathway (GO:0002429)3.43579934
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.30566431
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19939559
38NIK/NF-kappaB signaling (GO:0038061)3.19713263
39protein-chromophore linkage (GO:0018298)3.18418489
40cellular response to interferon-gamma (GO:0071346)3.07645820
41negative regulation of myotube differentiation (GO:0010832)3.04535912
42positive regulation of pseudopodium assembly (GO:0031274)3.02471861
43B cell mediated immunity (GO:0019724)2.97524146
44myeloid dendritic cell differentiation (GO:0043011)2.95448358
45response to interferon-gamma (GO:0034341)2.93505803
46dendritic cell chemotaxis (GO:0002407)2.90301077
47detection of external biotic stimulus (GO:0098581)2.86218267
48regulation of T cell tolerance induction (GO:0002664)2.79819381
49B cell receptor signaling pathway (GO:0050853)2.77398974
50myeloid dendritic cell activation (GO:0001773)2.74532080
51regulation of T-helper 1 cell differentiation (GO:0045625)2.74492426
52chronic inflammatory response (GO:0002544)2.74197407
53regulation of B cell receptor signaling pathway (GO:0050855)2.71140009
54regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70793254
55T-helper 1 type immune response (GO:0042088)2.70382703
56immune response-activating signal transduction (GO:0002757)2.68623021
57regulation of pseudopodium assembly (GO:0031272)2.67708599
58production of molecular mediator of immune response (GO:0002440)2.67162132
59angiotensin maturation (GO:0002003)2.66116610
60activation of immune response (GO:0002253)2.65964360
61regulation of gamma-delta T cell activation (GO:0046643)2.65139770
62production of molecular mediator involved in inflammatory response (GO:0002532)2.64542479
63peptide catabolic process (GO:0043171)2.63202943
64surfactant homeostasis (GO:0043129)2.63171541
65regulation of regulatory T cell differentiation (GO:0045589)2.62432294
66positive thymic T cell selection (GO:0045059)2.62031028
67positive regulation of type 2 immune response (GO:0002830)2.60090088
68regulation of integrin activation (GO:0033623)2.59076334
69positive regulation by symbiont of host defense response (GO:0052509)2.55371485
70modulation by symbiont of host defense response (GO:0052031)2.55371485
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55371485
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55371485
73positive regulation by organism of defense response of other organism involved in symbiotic interact2.55371485
74modulation by symbiont of host immune response (GO:0052553)2.55371485
75defense response to protozoan (GO:0042832)2.55298216
76maintenance of gastrointestinal epithelium (GO:0030277)2.54523866
77T cell costimulation (GO:0031295)2.51279349
78regulation of tolerance induction (GO:0002643)2.49819049
79dendritic cell migration (GO:0036336)2.48342103
80lymphocyte costimulation (GO:0031294)2.47426031
81interferon-gamma secretion (GO:0072643)2.46778522
82adhesion of symbiont to host cell (GO:0044650)2.45811933
83virion attachment to host cell (GO:0019062)2.45811933
84antigen processing and presentation via MHC class Ib (GO:0002475)2.43808816
85macrophage activation involved in immune response (GO:0002281)2.41996217
86detection of biotic stimulus (GO:0009595)2.41290879
87regulation of gamma-delta T cell differentiation (GO:0045586)2.41155240
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.40521925
89response to interferon-beta (GO:0035456)2.39567532
90regulation of necrotic cell death (GO:0010939)2.37496810
91dendritic cell differentiation (GO:0097028)2.35730553
92regulation of interferon-beta biosynthetic process (GO:0045357)2.35214558
93positive regulation of chemokine secretion (GO:0090197)2.35090408
94regulation of macrophage chemotaxis (GO:0010758)2.30987534
95regulation of glucose import in response to insulin stimulus (GO:2001273)2.30391818
96negative regulation of complement activation (GO:0045916)2.30309218
97regulation of chemokine secretion (GO:0090196)2.30285447
98positive regulation of B cell differentiation (GO:0045579)2.30173687
99negative regulation of humoral immune response (GO:0002921)2.29992403
100complement activation, classical pathway (GO:0006958)10.5245645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.13549160
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.75091783
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.71841866
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.79222265
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17102844
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.85439108
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83780423
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58946380
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.36645614
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28216858
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26203780
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15393397
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12849284
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05038139
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04974245
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02264483
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.01093700
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96285613
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91919112
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85425655
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84813869
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.82146245
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.77168458
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74304241
25RUNX_20019798_ChIP-Seq_JUKART_Human1.70690164
26VDR_24763502_ChIP-Seq_THP-1_Human1.69729894
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68407096
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68397568
29MYC_22102868_ChIP-Seq_BL_Human1.64727502
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64151961
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63935844
32VDR_21846776_ChIP-Seq_THP-1_Human1.63810751
33LXR_22292898_ChIP-Seq_THP-1_Human1.60754399
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53313781
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50690705
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48297479
37MYB_26560356_Chip-Seq_TH2_Human1.47768725
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.46136816
39CLOCK_20551151_ChIP-Seq_293T_Human1.45769280
40MAF_26560356_Chip-Seq_TH1_Human1.44587246
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44131802
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41443205
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40439975
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35735243
45TCF7_22412390_ChIP-Seq_EML_Mouse1.35543710
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.33906678
47SPI1_23127762_ChIP-Seq_K562_Human1.33806400
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.32496459
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31112973
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28801718
51GATA1_22025678_ChIP-Seq_K562_Human1.28751857
52MYB_26560356_Chip-Seq_TH1_Human1.28148423
53SOX2_20726797_ChIP-Seq_SW620_Human1.28102274
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.24708627
55SPI1_23547873_ChIP-Seq_NB4_Human1.23721117
56UTX_26944678_Chip-Seq_JUKART_Human1.23470615
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22893229
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.21945274
59GATA1_19941826_ChIP-Seq_K562_Human1.17607779
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16735819
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16526547
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.15596934
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14644453
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14107719
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14082150
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.13670937
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13322472
68SCL_19346495_ChIP-Seq_HPC-7_Human1.12610116
69VDR_24787735_ChIP-Seq_THP-1_Human1.11918589
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11775626
71EGR1_19032775_ChIP-ChIP_M12_Human1.10477985
72RACK7_27058665_Chip-Seq_MCF-7_Human1.10268408
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09893133
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08983110
75GATA4_25053715_ChIP-Seq_YYC3_Human1.07062708
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.05795220
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04261920
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.03597838
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03236860
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03195817
81GATA6_25053715_ChIP-Seq_YYC3_Human1.01109145
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00964451
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00926259
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00351850
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.99329012
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99058691
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97397975
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96429147
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94607480
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92679899
91GATA2_19941826_ChIP-Seq_K562_Human0.92665228
92GATA3_27048872_Chip-Seq_THYMUS_Human0.92426833
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90199913
94KDM2B_26808549_Chip-Seq_DND41_Human0.89882379
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89443275
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89293091
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87137871
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86768536
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84671062
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84626632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.51968588
2MP0003303_peritoneal_inflammation3.55105858
3MP0001835_abnormal_antigen_presentation3.38711238
4MP0003436_decreased_susceptibility_to3.13539528
5MP0005387_immune_system_phenotype3.08962226
6MP0001790_abnormal_immune_system3.08962226
7MP0010155_abnormal_intestine_physiology2.81577409
8MP0000685_abnormal_immune_system2.77127716
9MP0001800_abnormal_humoral_immune2.73171059
10MP0010234_abnormal_vibrissa_follicle2.67802158
11MP0005025_abnormal_response_to2.48907872
12MP0009785_altered_susceptibility_to2.36951082
13MP0003300_gastrointestinal_ulcer2.35482308
14MP0005000_abnormal_immune_tolerance2.31385485
15MP0005671_abnormal_response_to2.28608095
16MP0002452_abnormal_antigen_presenting2.15935874
17MP0005275_abnormal_skin_tensile2.14775011
18MP0000465_gastrointestinal_hemorrhage2.11416289
19MP0001873_stomach_inflammation2.10937959
20MP0003866_abnormal_defecation2.09796825
21MP0002148_abnormal_hypersensitivity_rea2.07520584
22MP0002138_abnormal_hepatobiliary_system2.00718164
23MP0002723_abnormal_immune_serum2.00407268
24MP0001533_abnormal_skeleton_physiology1.96521818
25MP0002419_abnormal_innate_immunity1.93327448
26MP0001819_abnormal_immune_cell1.89814079
27MP0002420_abnormal_adaptive_immunity1.88902620
28MP0005166_decreased_susceptibility_to1.86622601
29MP0004947_skin_inflammation1.86455982
30MP0004264_abnormal_extraembryonic_tissu1.84349537
31MP0003763_abnormal_thymus_physiology1.81189950
32MP0010352_gastrointestinal_tract_polyps1.72994382
33MP0002166_altered_tumor_susceptibility1.69627752
34MP0001845_abnormal_inflammatory_respons1.67672186
35MP0004858_abnormal_nervous_system1.67194367
36MP0006082_CNS_inflammation1.64490994
37MP0004782_abnormal_surfactant_physiolog1.60707231
38MP0005310_abnormal_salivary_gland1.58781723
39MP0005503_abnormal_tendon_morphology1.54374994
40MP0003183_abnormal_peptide_metabolism1.50146848
41MP0000716_abnormal_immune_system1.41648860
42MP0001663_abnormal_digestive_system1.40742652
43MP0009333_abnormal_splenocyte_physiolog1.39944362
44MP0008438_abnormal_cutaneous_collagen1.38845724
45MP0003448_altered_tumor_morphology1.34685102
46MP0003191_abnormal_cellular_cholesterol1.32704494
47MP0002398_abnormal_bone_marrow1.29967327
48MP0008004_abnormal_stomach_pH1.29031657
49MP0002405_respiratory_system_inflammati1.28677686
50MP0003075_altered_response_to1.28523303
51MP0005023_abnormal_wound_healing1.26071989
52MP0002933_joint_inflammation1.24467031
53MP0005464_abnormal_platelet_physiology1.20794547
54MP0000343_altered_response_to1.19625381
55MP0000858_altered_metastatic_potential1.19241895
56MP0002998_abnormal_bone_remodeling1.18707454
57MP0003045_fibrosis1.18086784
58MP0002006_tumorigenesis1.16896721
59MP0000604_amyloidosis1.13144351
60MP0009840_abnormal_foam_cell1.12066238
61MP0002139_abnormal_hepatobiliary_system1.11823266
62MP0003279_aneurysm1.11465273
63MP0008469_abnormal_protein_level1.10279220
64MP0002429_abnormal_blood_cell1.10245382
65MP0000490_abnormal_crypts_of1.09628310
66MP0002277_abnormal_respiratory_mucosa1.08928674
67MP0005390_skeleton_phenotype1.05196593
68MP0001851_eye_inflammation1.04540929
69MP0005381_digestive/alimentary_phenotyp1.04399717
70MP0000477_abnormal_intestine_morphology1.04255101
71MP0004510_myositis1.02815156
72MP0003453_abnormal_keratinocyte_physiol1.00844554
73MP0002722_abnormal_immune_system0.99836887
74MP0000689_abnormal_spleen_morphology0.96334570
75MP0009278_abnormal_bone_marrow0.96252893
76MP0002796_impaired_skin_barrier0.94040111
77MP0003091_abnormal_cell_migration0.93412983
78MP0009764_decreased_sensitivity_to0.92642014
79MP0000249_abnormal_blood_vessel0.91922272
80MP0003566_abnormal_cell_adhesion0.91773026
81MP0001666_abnormal_nutrient_absorption0.91179478
82MP0003868_abnormal_feces_composition0.90983540
83MP0005164_abnormal_response_to0.89306304
84MP0008260_abnormal_autophagy0.89023214
85MP0005058_abnormal_lysosome_morphology0.88937343
86MP0003828_pulmonary_edema0.88035783
87MP0005451_abnormal_body_composition0.87181864
88MP0003329_amyloid_beta_deposits0.85480461
89MP0001664_abnormal_digestion0.85247682
90MP0004019_abnormal_vitamin_homeostasis0.83745380
91MP0005360_urolithiasis0.79341238
92MP0003011_delayed_dark_adaptation0.78934228
93MP0005165_increased_susceptibility_to0.77000687
94MP0000678_abnormal_parathyroid_gland0.76055772
95MP0002136_abnormal_kidney_physiology0.75375181
96MP0005085_abnormal_gallbladder_physiolo0.74907725
97MP0001958_emphysema0.74165814
98MP0001216_abnormal_epidermal_layer0.73404964
99MP0003795_abnormal_bone_structure0.72755226
100MP0001879_abnormal_lymphatic_vessel0.72088797

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.40875832
2Prostate neoplasm (HP:0100787)5.84076014
3Abnormality of macrophages (HP:0004311)5.00199837
4Eczematoid dermatitis (HP:0000976)4.63296367
5Malnutrition (HP:0004395)4.20034147
6Abnormality of the prostate (HP:0008775)4.14939950
7Abnormality of complement system (HP:0005339)4.00940272
8Vasculitis (HP:0002633)3.91788643
9Complement deficiency (HP:0004431)3.80377463
10Glomerulonephritis (HP:0000099)3.78126812
11Agammaglobulinemia (HP:0004432)3.65767906
12Colitis (HP:0002583)3.64440357
13Recurrent bronchitis (HP:0002837)3.58556816
14Gastrointestinal stroma tumor (HP:0100723)3.55148477
15Spontaneous hematomas (HP:0007420)3.24905291
16Premature loss of primary teeth (HP:0006323)3.24607204
17Abnormality of cells of the lymphoid lineage (HP:0012140)3.21656276
18Increased IgE level (HP:0003212)3.15659351
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.15021148
20Nephritis (HP:0000123)3.13939253
21Cellulitis (HP:0100658)3.11539071
22Inflammation of the large intestine (HP:0002037)3.10974937
23Recurrent bacterial skin infections (HP:0005406)3.09102612
24Meningitis (HP:0001287)3.07148467
25Recurrent abscess formation (HP:0002722)3.00849213
26Gastrointestinal inflammation (HP:0004386)2.97818150
27Gastrointestinal infarctions (HP:0005244)2.97598591
28Skin rash (HP:0000988)2.95580148
29Leukocytosis (HP:0001974)2.90762940
30Gingivitis (HP:0000230)2.90530828
31Osteomyelitis (HP:0002754)2.73491327
32Hyperactive renin-angiotensin system (HP:0000841)2.72646890
33Recurrent viral infections (HP:0004429)2.69782540
34Abnormality of the nasal mucosa (HP:0000433)2.66873442
35Myositis (HP:0100614)2.66632843
36Chronic otitis media (HP:0000389)2.66218676
37Emphysema (HP:0002097)2.65834128
38Mediastinal lymphadenopathy (HP:0100721)2.61539579
39Chronic diarrhea (HP:0002028)2.59187211
40Urticaria (HP:0001025)2.58932043
41Orchitis (HP:0100796)2.57403560
42Interstitial pulmonary disease (HP:0006530)2.54721364
43Villous atrophy (HP:0011473)2.54130473
44Abnormality of small intestinal villus morphology (HP:0011472)2.54130473
45Hemoptysis (HP:0002105)2.52484312
46Segmental peripheral demyelination/remyelination (HP:0003481)2.47211316
47Recurrent fungal infections (HP:0002841)2.42902754
48Abnormality of male internal genitalia (HP:0000022)2.41412669
49Alopecia of scalp (HP:0002293)2.40984211
50Abnormality of B cell number (HP:0010975)2.38383355
51Elevated erythrocyte sedimentation rate (HP:0003565)2.36160006
52Recurrent gram-negative bacterial infections (HP:0005420)2.35509799
53Pulmonary infiltrates (HP:0002113)2.34628513
54Right ventricular cardiomyopathy (HP:0011663)2.32378260
55Recurrent sinusitis (HP:0011108)2.29794803
56Chronic obstructive pulmonary disease (HP:0006510)2.29038001
57Obstructive lung disease (HP:0006536)2.29038001
58Recurrent skin infections (HP:0001581)2.27002213
59Recurrent cutaneous fungal infections (HP:0011370)2.24322937
60Chronic mucocutaneous candidiasis (HP:0002728)2.24322937
61Neoplasm of the lung (HP:0100526)2.20250417
62Pustule (HP:0200039)2.16434664
63Panhypogammaglobulinemia (HP:0003139)2.15821474
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.14851161
65Xerostomia (HP:0000217)2.14638915
66Bronchitis (HP:0012387)2.14526769
67Hypergammaglobulinemia (HP:0010702)2.13950215
68Flat acetabular roof (HP:0003180)2.12467932
69Periodontitis (HP:0000704)2.12263022
70Autoimmune hemolytic anemia (HP:0001890)2.11129601
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10312727
72Abnormal hair laboratory examination (HP:0003328)2.08721538
73Restrictive lung disease (HP:0002091)2.08592520
74Skin ulcer (HP:0200042)2.05539906
75Optic neuritis (HP:0100653)2.05289406
76Retrobulbar optic neuritis (HP:0100654)2.05289406
77Chest pain (HP:0100749)2.04246939
78Purpura (HP:0000979)2.03053666
79IgM deficiency (HP:0002850)2.01778481
80Hemorrhage of the eye (HP:0011885)2.01178447
81Abnormality of the peritoneum (HP:0002585)2.00854770
82Nasal polyposis (HP:0100582)2.00408684
83Fragile skin (HP:0001030)1.97482088
84Pili torti (HP:0003777)1.96472069
85Hematochezia (HP:0002573)1.95588571
86Lymphopenia (HP:0001888)1.95320176
87Recurrent pneumonia (HP:0006532)1.94976424
88Hypermelanotic macule (HP:0001034)1.93581924
89Ankyloglossia (HP:0010296)1.92681104
90Recurrent lower respiratory tract infections (HP:0002783)1.92637807
91Thick nail (HP:0001805)1.90524832
92Ileus (HP:0002595)1.89125494
93Increased IgM level (HP:0003496)1.88601072
94Decreased circulating renin level (HP:0003351)1.88551566
95Autoimmune thrombocytopenia (HP:0001973)1.88266961
96Polygenic inheritance (HP:0010982)1.88210527
97Abnormality of T cell physiology (HP:0011840)1.87767840
98Verrucae (HP:0200043)1.86965354
99Papilloma (HP:0012740)1.86965354
100Osteolytic defects of the hand bones (HP:0009699)1.85972182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.05237234
2TYK23.52669344
3MAP4K13.44920113
4MST1R3.29724578
5FGFR43.09653762
6BLK2.78270492
7RIPK12.71080121
8RIPK42.69588418
9EPHA32.54531812
10PRPF4B2.42460652
11JAK12.21022872
12EPHB12.09673161
13MAP3K141.92399148
14JAK31.91998793
15FGFR31.90370759
16CDC42BPA1.89452988
17KIT1.88404868
18IKBKE1.87071166
19CSK1.55500663
20ZAP701.54359747
21MAP3K101.53100849
22TBK11.51989841
23GRK61.45814186
24FES1.45169029
25SMG11.41733811
26IRAK41.39168510
27TXK1.26729262
28JAK21.26155487
29MAP3K11.24573793
30SYK1.21090074
31PIK3CA1.19325669
32EPHA21.17035867
33BTK1.15836634
34LYN1.15143072
35SIK31.13060591
36NLK1.12440762
37PDGFRA1.11692206
38IRAK11.11221522
39TRIB31.09453092
40CSF1R1.07301482
41MET1.04450914
42TGFBR21.04404623
43FER1.00194019
44MAP3K130.99881537
45STK240.96032927
46MATK0.95934380
47TGFBR10.93885510
48ACVR1B0.93399598
49HCK0.93222450
50PTK60.90716024
51TAOK10.88312037
52IKBKB0.84619057
53HIPK20.83161122
54PKN20.81879191
55MAP3K30.81532465
56DDR20.80383553
57BMPR20.75623958
58LCK0.75296933
59EPHB20.73537702
60LRRK20.72324812
61MAPK70.71860697
62PRKG20.70231500
63FGR0.68519485
64RET0.68082512
65YES10.62977405
66PDPK10.58252540
67FYN0.57322069
68MAP3K60.56493114
69ITK0.54189124
70MAP2K30.53707261
71MAPK110.49603273
72LMTK20.49019420
73PDK10.47330074
74PDGFRB0.47277547
75MAPKAPK20.46733914
76PRKD20.46369285
77TNK20.45872410
78MYLK0.44955395
79MAP3K20.43818011
80IRAK30.43327731
81MAP3K110.41783891
82PAK40.41538140
83DMPK0.39562647
84CDK60.39012473
85TEC0.37535492
86SIK10.37418220
87CHUK0.37164416
88GRK50.35943465
89MAP2K20.35526006
90OXSR10.33642932
91MAPK40.33530093
92NEK90.32900935
93KSR20.32772787
94BMX0.32349991
95PRKCQ0.32118042
96TAOK30.31643387
97PRKCD0.31153893
98STK390.28969378
99MAPK120.28547370
100ABL10.27494651

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.91979353
2Asthma_Homo sapiens_hsa053103.60463454
3Allograft rejection_Homo sapiens_hsa053303.34577705
4Autoimmune thyroid disease_Homo sapiens_hsa053203.20516595
5Graft-versus-host disease_Homo sapiens_hsa053323.08844359
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.06747032
7Leishmaniasis_Homo sapiens_hsa051402.67407539
8Type I diabetes mellitus_Homo sapiens_hsa049402.52935599
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42721984
10Antigen processing and presentation_Homo sapiens_hsa046122.25079411
11Viral myocarditis_Homo sapiens_hsa054161.98720010
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88262589
13Primary immunodeficiency_Homo sapiens_hsa053401.85232953
14Toxoplasmosis_Homo sapiens_hsa051451.77540650
15Osteoclast differentiation_Homo sapiens_hsa043801.72615989
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.67236547
17Pertussis_Homo sapiens_hsa051331.65278742
18B cell receptor signaling pathway_Homo sapiens_hsa046621.59032758
19Influenza A_Homo sapiens_hsa051641.55364149
20Tuberculosis_Homo sapiens_hsa051521.54817534
21Hematopoietic cell lineage_Homo sapiens_hsa046401.50963522
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.43798281
23Rheumatoid arthritis_Homo sapiens_hsa053231.37167291
24Herpes simplex infection_Homo sapiens_hsa051681.28723382
25Other glycan degradation_Homo sapiens_hsa005111.28587570
26Complement and coagulation cascades_Homo sapiens_hsa046101.24649539
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18339879
28Malaria_Homo sapiens_hsa051441.17503491
29TNF signaling pathway_Homo sapiens_hsa046681.12260753
30Phagosome_Homo sapiens_hsa041451.10455307
31Hepatitis C_Homo sapiens_hsa051601.09812741
32Measles_Homo sapiens_hsa051621.09472467
33Chemokine signaling pathway_Homo sapiens_hsa040621.07588327
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05167292
35Arginine biosynthesis_Homo sapiens_hsa002201.02957309
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.02648481
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02228807
38Systemic lupus erythematosus_Homo sapiens_hsa053220.97038841
39Renin-angiotensin system_Homo sapiens_hsa046140.95925720
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95503564
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.92405691
42Sulfur metabolism_Homo sapiens_hsa009200.91341352
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90737157
44African trypanosomiasis_Homo sapiens_hsa051430.89934391
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86615552
46Fat digestion and absorption_Homo sapiens_hsa049750.83594396
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82789644
48Acute myeloid leukemia_Homo sapiens_hsa052210.81406762
49Protein digestion and absorption_Homo sapiens_hsa049740.79435132
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79018627
51Fructose and mannose metabolism_Homo sapiens_hsa000510.75191181
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74391054
53Amoebiasis_Homo sapiens_hsa051460.71774010
54Mineral absorption_Homo sapiens_hsa049780.68634941
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68009696
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66379242
57Apoptosis_Homo sapiens_hsa042100.62715746
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62447223
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61585413
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58882621
61Hepatitis B_Homo sapiens_hsa051610.58224762
62Pancreatic secretion_Homo sapiens_hsa049720.58115757
63T cell receptor signaling pathway_Homo sapiens_hsa046600.56418367
64Arachidonic acid metabolism_Homo sapiens_hsa005900.55447916
65Pancreatic cancer_Homo sapiens_hsa052120.54818965
66Lysosome_Homo sapiens_hsa041420.52763549
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51453588
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50761802
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.50537640
70Retinol metabolism_Homo sapiens_hsa008300.49854677
71HTLV-I infection_Homo sapiens_hsa051660.49488920
72Prolactin signaling pathway_Homo sapiens_hsa049170.49439597
73Salmonella infection_Homo sapiens_hsa051320.48323212
74Histidine metabolism_Homo sapiens_hsa003400.47254451
75Platelet activation_Homo sapiens_hsa046110.47052660
76Epstein-Barr virus infection_Homo sapiens_hsa051690.45690105
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44917704
78Prion diseases_Homo sapiens_hsa050200.43527196
79Legionellosis_Homo sapiens_hsa051340.43181971
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42295595
81Caffeine metabolism_Homo sapiens_hsa002320.42079425
82HIF-1 signaling pathway_Homo sapiens_hsa040660.41099732
83Starch and sucrose metabolism_Homo sapiens_hsa005000.40914094
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40864613
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40092061
86Notch signaling pathway_Homo sapiens_hsa043300.39232613
87Chronic myeloid leukemia_Homo sapiens_hsa052200.38097794
88Nitrogen metabolism_Homo sapiens_hsa009100.37560877
89Renal cell carcinoma_Homo sapiens_hsa052110.36522175
90VEGF signaling pathway_Homo sapiens_hsa043700.33299172
91Galactose metabolism_Homo sapiens_hsa000520.32695353
92PPAR signaling pathway_Homo sapiens_hsa033200.31920174
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.30093367
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29854724
95Linoleic acid metabolism_Homo sapiens_hsa005910.27614325
96Viral carcinogenesis_Homo sapiens_hsa052030.27497518
97Thyroid hormone synthesis_Homo sapiens_hsa049180.27247647
98Vitamin digestion and absorption_Homo sapiens_hsa049770.26265723
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26201805
100Small cell lung cancer_Homo sapiens_hsa052220.26179760

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