IGHV4-59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.83352841
2complement activation (GO:0006956)8.71037165
3glomerular filtration (GO:0003094)7.59944636
4renal filtration (GO:0097205)6.87913595
5protein activation cascade (GO:0072376)6.44882479
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.94884324
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.93643287
8regulation of respiratory burst (GO:0060263)5.88304000
9antigen processing and presentation of endogenous antigen (GO:0019883)5.63495456
10Fc-gamma receptor signaling pathway (GO:0038094)5.38925837
11Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.38925837
12immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.38925837
13Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.35466476
14humoral immune response (GO:0006959)5.06165967
15antibacterial humoral response (GO:0019731)4.86921450
16antimicrobial humoral response (GO:0019730)4.86714917
17regulation of cellular extravasation (GO:0002691)4.19392951
18regulation of dendritic cell antigen processing and presentation (GO:0002604)4.14560098
19retina homeostasis (GO:0001895)4.06808289
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04878580
21immunoglobulin mediated immune response (GO:0016064)3.89845100
22interferon-gamma-mediated signaling pathway (GO:0060333)3.84329831
23detection of bacterium (GO:0016045)3.82758552
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.81500735
25type I interferon signaling pathway (GO:0060337)3.80229762
26cellular response to type I interferon (GO:0071357)3.80229762
27response to type I interferon (GO:0034340)3.79923173
28regulation of antigen processing and presentation (GO:0002577)3.77985367
29detection of other organism (GO:0098543)3.74178124
30positive regulation of antigen processing and presentation (GO:0002579)3.65552781
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62550835
32negative regulation of cell killing (GO:0031342)3.62550835
33germinal center formation (GO:0002467)3.52454577
34immune response-activating cell surface receptor signaling pathway (GO:0002429)3.42530540
35positive regulation of Cdc42 GTPase activity (GO:0043089)3.35545975
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33881140
37positive regulation of gamma-delta T cell activation (GO:0046645)3.24296786
38cellular response to interferon-gamma (GO:0071346)3.11272586
39NIK/NF-kappaB signaling (GO:0038061)3.11080622
40positive regulation of pseudopodium assembly (GO:0031274)3.10562765
41negative regulation of myotube differentiation (GO:0010832)3.06268443
42angiotensin maturation (GO:0002003)2.98177999
43response to interferon-gamma (GO:0034341)2.97216799
44B cell mediated immunity (GO:0019724)2.93241214
45dendritic cell chemotaxis (GO:0002407)2.92798146
46myeloid dendritic cell differentiation (GO:0043011)2.87259755
47detection of external biotic stimulus (GO:0098581)2.81212898
48regulation of pseudopodium assembly (GO:0031272)2.77032458
49regulation of integrin activation (GO:0033623)2.76415272
50chronic inflammatory response (GO:0002544)2.75836256
51regulation of T cell tolerance induction (GO:0002664)2.72562302
52regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72401253
53myeloid dendritic cell activation (GO:0001773)2.71578456
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.71332505
55production of molecular mediator of immune response (GO:0002440)2.69474424
56immune response-activating signal transduction (GO:0002757)2.66277941
57regulation of regulatory T cell differentiation (GO:0045589)2.65504028
58protein-chromophore linkage (GO:0018298)2.64265364
59activation of immune response (GO:0002253)2.63978723
60interferon-gamma secretion (GO:0072643)2.60214101
61T-helper 1 type immune response (GO:0042088)2.58171995
62response to interferon-beta (GO:0035456)2.52923265
63surfactant homeostasis (GO:0043129)2.51899317
64maintenance of gastrointestinal epithelium (GO:0030277)2.50213104
65peptide catabolic process (GO:0043171)2.48290402
66T cell costimulation (GO:0031295)2.47928058
67dendritic cell migration (GO:0036336)2.47851835
68regulation of tolerance induction (GO:0002643)2.47124124
69regulation of T-helper 1 cell differentiation (GO:0045625)2.47006233
70adhesion of symbiont to host cell (GO:0044650)2.46237351
71virion attachment to host cell (GO:0019062)2.46237351
72regulation of glucose import in response to insulin stimulus (GO:2001273)2.45786546
73regulation of gamma-delta T cell activation (GO:0046643)2.45320114
74lymphocyte costimulation (GO:0031294)2.44020590
75regulation of necrotic cell death (GO:0010939)2.42847202
76positive regulation of T cell migration (GO:2000406)2.42326335
77regulation of macrophage chemotaxis (GO:0010758)2.41137232
78positive thymic T cell selection (GO:0045059)2.41097966
79regulation of B cell receptor signaling pathway (GO:0050855)2.40799579
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39868957
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.39868957
82modulation by symbiont of host immune response (GO:0052553)2.39868957
83positive regulation by symbiont of host defense response (GO:0052509)2.39868957
84modulation by symbiont of host defense response (GO:0052031)2.39868957
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39868957
86B cell receptor signaling pathway (GO:0050853)2.38189024
87detection of biotic stimulus (GO:0009595)2.37846959
88antigen processing and presentation via MHC class Ib (GO:0002475)2.37841373
89regulation of T cell migration (GO:2000404)2.35852931
90positive regulation of granulocyte chemotaxis (GO:0071624)2.34835508
91oligosaccharide biosynthetic process (GO:0009312)2.30174747
92dendritic cell differentiation (GO:0097028)2.30094178
93negative regulation of innate immune response (GO:0045824)2.28656597
94positive regulation of neutrophil chemotaxis (GO:0090023)2.28388463
95positive regulation of neutrophil migration (GO:1902624)2.28388463
96negative regulation of humoral immune response (GO:0002921)2.27259927
97respiratory burst (GO:0045730)2.25877427
98negative regulation of complement activation (GO:0045916)2.25082805
99adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.24985691
100complement activation, classical pathway (GO:0006958)10.9968259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.98585229
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.85746204
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.63138326
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.03540816
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.21593258
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85199470
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.78540217
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52068477
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.26842011
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19627936
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19349475
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.12075470
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08885970
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04160680
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98768913
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95490133
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.89620122
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87746900
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87475553
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86178360
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79616018
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.75649676
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74786315
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70777139
25VDR_24763502_ChIP-Seq_THP-1_Human1.70056178
26LXR_22292898_ChIP-Seq_THP-1_Human1.69595932
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.68785123
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66540567
29VDR_21846776_ChIP-Seq_THP-1_Human1.65199821
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.62365037
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59995524
32RUNX_20019798_ChIP-Seq_JUKART_Human1.56895257
33CLOCK_20551151_ChIP-Seq_293T_Human1.50201271
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46700362
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46396158
36MYC_22102868_ChIP-Seq_BL_Human1.44607592
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.43016356
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41430897
39MYB_26560356_Chip-Seq_TH2_Human1.39620414
40MAF_26560356_Chip-Seq_TH1_Human1.38345080
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36852974
42SOX2_20726797_ChIP-Seq_SW620_Human1.36064268
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35706565
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35582481
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34139037
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.32750479
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30068540
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.30029273
49TCF7_22412390_ChIP-Seq_EML_Mouse1.29996491
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29379725
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25946253
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.25427252
53SPI1_23127762_ChIP-Seq_K562_Human1.25248050
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.24387269
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23864797
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.22758465
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21578554
58SPI1_23547873_ChIP-Seq_NB4_Human1.21105784
59UTX_26944678_Chip-Seq_JUKART_Human1.20799120
60MYB_26560356_Chip-Seq_TH1_Human1.19871298
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19516626
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18905021
63RACK7_27058665_Chip-Seq_MCF-7_Human1.18258013
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17671050
65GATA4_25053715_ChIP-Seq_YYC3_Human1.16399960
66GATA1_19941826_ChIP-Seq_K562_Human1.16397235
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16286910
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16040536
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15912327
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15713966
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15123963
72EGR1_19032775_ChIP-ChIP_M12_Human1.14604136
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.13796649
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12444217
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.10724885
76VDR_24787735_ChIP-Seq_THP-1_Human1.09048734
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.08101451
78GATA6_25053715_ChIP-Seq_YYC3_Human1.06683194
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03185144
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03170903
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01686204
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01648836
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01579730
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99764121
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97786234
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.97178657
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97059647
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96800298
89GATA1_22025678_ChIP-Seq_K562_Human0.94013494
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92025714
91SCL_19346495_ChIP-Seq_HPC-7_Human0.91720705
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91503340
93GATA2_19941826_ChIP-Seq_K562_Human0.89826988
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89682492
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89083088
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87918269
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87466433
98GATA3_27048872_Chip-Seq_THYMUS_Human0.86901142
99KDM2B_26808549_Chip-Seq_DND41_Human0.86193456
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.85186799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.54341459
2MP0003303_peritoneal_inflammation3.38200700
3MP0001835_abnormal_antigen_presentation3.19781571
4MP0010234_abnormal_vibrissa_follicle3.16264224
5MP0003436_decreased_susceptibility_to3.10867607
6MP0005387_immune_system_phenotype2.94640462
7MP0001790_abnormal_immune_system2.94640462
8MP0010155_abnormal_intestine_physiology2.87991562
9MP0000685_abnormal_immune_system2.77148145
10MP0001800_abnormal_humoral_immune2.57940747
11MP0005025_abnormal_response_to2.46789084
12MP0009785_altered_susceptibility_to2.39218578
13MP0005671_abnormal_response_to2.34490728
14MP0005000_abnormal_immune_tolerance2.22299391
15MP0003300_gastrointestinal_ulcer2.21594044
16MP0001873_stomach_inflammation2.15589721
17MP0003866_abnormal_defecation2.12372879
18MP0005275_abnormal_skin_tensile2.05151699
19MP0002138_abnormal_hepatobiliary_system2.04161022
20MP0000465_gastrointestinal_hemorrhage2.03222832
21MP0002452_abnormal_antigen_presenting2.03045038
22MP0002148_abnormal_hypersensitivity_rea2.01961758
23MP0001533_abnormal_skeleton_physiology2.01185620
24MP0004264_abnormal_extraembryonic_tissu2.00958160
25MP0005166_decreased_susceptibility_to1.92235254
26MP0002723_abnormal_immune_serum1.90511487
27MP0002419_abnormal_innate_immunity1.86582766
28MP0010352_gastrointestinal_tract_polyps1.81901938
29MP0004782_abnormal_surfactant_physiolog1.80238714
30MP0001819_abnormal_immune_cell1.80135508
31MP0002420_abnormal_adaptive_immunity1.78734376
32MP0004947_skin_inflammation1.77906462
33MP0002166_altered_tumor_susceptibility1.70681046
34MP0004858_abnormal_nervous_system1.64906481
35MP0001845_abnormal_inflammatory_respons1.64797146
36MP0006082_CNS_inflammation1.60988096
37MP0003763_abnormal_thymus_physiology1.60966064
38MP0003183_abnormal_peptide_metabolism1.50453554
39MP0002139_abnormal_hepatobiliary_system1.50363132
40MP0003191_abnormal_cellular_cholesterol1.47042264
41MP0001663_abnormal_digestive_system1.46883802
42MP0009333_abnormal_splenocyte_physiolog1.46706391
43MP0005503_abnormal_tendon_morphology1.45684064
44MP0005310_abnormal_salivary_gland1.42314021
45MP0008438_abnormal_cutaneous_collagen1.34680167
46MP0000716_abnormal_immune_system1.32360659
47MP0003448_altered_tumor_morphology1.31613974
48MP0009840_abnormal_foam_cell1.30913574
49MP0005023_abnormal_wound_healing1.29343870
50MP0003075_altered_response_to1.27729514
51MP0000858_altered_metastatic_potential1.25444841
52MP0002933_joint_inflammation1.22230441
53MP0002006_tumorigenesis1.22024989
54MP0002277_abnormal_respiratory_mucosa1.21956011
55MP0002398_abnormal_bone_marrow1.21516200
56MP0005464_abnormal_platelet_physiology1.21211136
57MP0002405_respiratory_system_inflammati1.19759843
58MP0000343_altered_response_to1.18025678
59MP0002998_abnormal_bone_remodeling1.17899561
60MP0008004_abnormal_stomach_pH1.17361244
61MP0003045_fibrosis1.16394893
62MP0000604_amyloidosis1.15988959
63MP0002796_impaired_skin_barrier1.13889433
64MP0000490_abnormal_crypts_of1.12847810
65MP0008469_abnormal_protein_level1.11488252
66MP0005381_digestive/alimentary_phenotyp1.09081950
67MP0000477_abnormal_intestine_morphology1.08786486
68MP0005390_skeleton_phenotype1.07521550
69MP0005360_urolithiasis1.04248046
70MP0002429_abnormal_blood_cell1.03822814
71MP0009278_abnormal_bone_marrow1.02907149
72MP0001666_abnormal_nutrient_absorption1.02157989
73MP0003453_abnormal_keratinocyte_physiol1.01969007
74MP0003279_aneurysm1.01537377
75MP0004510_myositis1.00434696
76MP0001851_eye_inflammation0.99872392
77MP0009764_decreased_sensitivity_to0.97284283
78MP0003329_amyloid_beta_deposits0.96015931
79MP0003868_abnormal_feces_composition0.95207153
80MP0003828_pulmonary_edema0.94112504
81MP0005085_abnormal_gallbladder_physiolo0.92885570
82MP0002722_abnormal_immune_system0.91049060
83MP0001664_abnormal_digestion0.90022001
84MP0000249_abnormal_blood_vessel0.89907395
85MP0005164_abnormal_response_to0.89554674
86MP0005058_abnormal_lysosome_morphology0.88829761
87MP0005451_abnormal_body_composition0.88434834
88MP0000689_abnormal_spleen_morphology0.86591431
89MP0003566_abnormal_cell_adhesion0.80287551
90MP0000678_abnormal_parathyroid_gland0.79765818
91MP0003091_abnormal_cell_migration0.78987347
92MP0001216_abnormal_epidermal_layer0.78846249
93MP0005409_darkened_coat_color0.77725655
94MP0005165_increased_susceptibility_to0.75784513
95MP0005365_abnormal_bile_salt0.75671505
96MP0003795_abnormal_bone_structure0.74949228
97MP0001958_emphysema0.73914704
98MP0002136_abnormal_kidney_physiology0.72973524
99MP0009643_abnormal_urine_homeostasis0.72496857
100MP0008260_abnormal_autophagy0.72363176

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.31205955
2Prostate neoplasm (HP:0100787)5.56794897
3Abnormality of macrophages (HP:0004311)4.71233037
4Eczematoid dermatitis (HP:0000976)4.58189159
5Malnutrition (HP:0004395)4.23439257
6Abnormality of complement system (HP:0005339)4.16353865
7Complement deficiency (HP:0004431)3.96765236
8Abnormality of the prostate (HP:0008775)3.94634666
9Glomerulonephritis (HP:0000099)3.90295446
10Vasculitis (HP:0002633)3.78965849
11Increased IgE level (HP:0003212)3.60614052
12Agammaglobulinemia (HP:0004432)3.60565592
13Recurrent bronchitis (HP:0002837)3.46297030
14Colitis (HP:0002583)3.37238380
15Gastrointestinal stroma tumor (HP:0100723)3.34091730
16Nephritis (HP:0000123)3.23630311
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.18918743
18Premature loss of primary teeth (HP:0006323)3.15515900
19Spontaneous hematomas (HP:0007420)3.15001541
20Hyperactive renin-angiotensin system (HP:0000841)3.12053460
21Abnormality of cells of the lymphoid lineage (HP:0012140)3.04633260
22Cellulitis (HP:0100658)3.00758606
23Meningitis (HP:0001287)2.97602354
24Inflammation of the large intestine (HP:0002037)2.96520109
25Recurrent bacterial skin infections (HP:0005406)2.94917475
26Recurrent abscess formation (HP:0002722)2.91410531
27Skin rash (HP:0000988)2.90695676
28Leukocytosis (HP:0001974)2.86734003
29Gingivitis (HP:0000230)2.84274404
30Gastrointestinal inflammation (HP:0004386)2.84033719
31Gastrointestinal infarctions (HP:0005244)2.83338375
32Abnormality of small intestinal villus morphology (HP:0011472)2.79130511
33Villous atrophy (HP:0011473)2.79130511
34Abnormality of the nasal mucosa (HP:0000433)2.77760749
35Chronic otitis media (HP:0000389)2.67755919
36Osteomyelitis (HP:0002754)2.67713210
37Recurrent viral infections (HP:0004429)2.66544775
38Myositis (HP:0100614)2.65973122
39Urticaria (HP:0001025)2.65736502
40Emphysema (HP:0002097)2.62892162
41Chronic diarrhea (HP:0002028)2.61087154
42Orchitis (HP:0100796)2.52508466
43Abnormality of B cell number (HP:0010975)2.47106254
44Interstitial pulmonary disease (HP:0006530)2.46694143
45Right ventricular cardiomyopathy (HP:0011663)2.46581574
46Hemoptysis (HP:0002105)2.44717295
47Recurrent fungal infections (HP:0002841)2.40968145
48Elevated erythrocyte sedimentation rate (HP:0003565)2.40508860
49Alopecia of scalp (HP:0002293)2.39810531
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37854289
51Recurrent gram-negative bacterial infections (HP:0005420)2.36161034
52Mediastinal lymphadenopathy (HP:0100721)2.35936364
53Flat acetabular roof (HP:0003180)2.34406918
54Autoimmune hemolytic anemia (HP:0001890)2.32718677
55Hypergammaglobulinemia (HP:0010702)2.31762176
56Pulmonary infiltrates (HP:0002113)2.31392660
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29957999
58Pustule (HP:0200039)2.28565298
59Abnormality of male internal genitalia (HP:0000022)2.26552216
60Obstructive lung disease (HP:0006536)2.26325576
61Chronic obstructive pulmonary disease (HP:0006510)2.26325576
62Decreased circulating renin level (HP:0003351)2.26064151
63Recurrent sinusitis (HP:0011108)2.19279767
64Recurrent skin infections (HP:0001581)2.18133864
65Chronic mucocutaneous candidiasis (HP:0002728)2.16182257
66Recurrent cutaneous fungal infections (HP:0011370)2.16182257
67Bronchitis (HP:0012387)2.15718728
68Autoimmune thrombocytopenia (HP:0001973)2.15687875
69Neoplasm of the lung (HP:0100526)2.15289242
70Ileus (HP:0002595)2.12984551
71Nasal polyposis (HP:0100582)2.12260305
72Panhypogammaglobulinemia (HP:0003139)2.11376782
73Periodontitis (HP:0000704)2.07400612
74Skin ulcer (HP:0200042)2.06573473
75Hemorrhage of the eye (HP:0011885)2.06183834
76Purpura (HP:0000979)2.01191892
77Chest pain (HP:0100749)2.00378281
78Optic neuritis (HP:0100653)1.99346587
79Retrobulbar optic neuritis (HP:0100654)1.99346587
80Xerostomia (HP:0000217)1.99268267
81Recurrent lower respiratory tract infections (HP:0002783)1.98989621
82Fragile skin (HP:0001030)1.98766936
83Restrictive lung disease (HP:0002091)1.98485099
84Polygenic inheritance (HP:0010982)1.98077389
85Recurrent pneumonia (HP:0006532)1.97630164
86Metabolic alkalosis (HP:0200114)1.94577527
87Increased IgM level (HP:0003496)1.93899825
88Ankyloglossia (HP:0010296)1.93415028
89Abnormality of T cell physiology (HP:0011840)1.92939018
90Hypermelanotic macule (HP:0001034)1.92197921
91Abnormal hair laboratory examination (HP:0003328)1.91127519
92Thick nail (HP:0001805)1.87750800
93B lymphocytopenia (HP:0010976)1.86999037
94Abnormality of renin-angiotensin system (HP:0000847)1.86731510
95Segmental peripheral demyelination/remyelination (HP:0003481)1.86448268
96Verrucae (HP:0200043)1.86330590
97Papilloma (HP:0012740)1.86330590
98Alkalosis (HP:0001948)1.83937797
99Pili torti (HP:0003777)1.83724268
100Polycythemia (HP:0001901)1.83615625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.82318597
2TYK23.48156926
3MST1R3.36151122
4MAP4K13.28606285
5FGFR43.11463539
6RIPK12.89019329
7PRPF4B2.74182921
8RIPK42.67432582
9BLK2.65318562
10EPHA32.50843424
11JAK12.21817586
12EPHB12.10522928
13KIT2.02351911
14CDC42BPA1.93822796
15MAP3K141.91479161
16IKBKE1.87866321
17FGFR31.83242132
18JAK31.79016055
19PIK3CA1.62865886
20TBK11.61561056
21ZAP701.52713827
22CSK1.49081362
23SMG11.44890197
24FES1.40704969
25EPHA21.40177663
26MAP3K101.36578247
27GRK61.35834713
28MAP3K11.26960438
29TRIB31.25187258
30JAK21.23619475
31IRAK41.22570348
32PDGFRA1.18108991
33LYN1.16451959
34SYK1.15102621
35TXK1.14429623
36IRAK11.09725779
37ACVR1B1.09670840
38MATK1.08844294
39STK241.08295591
40CSF1R1.04953240
41FER1.04400442
42MET0.99643904
43PTK60.99438496
44PKN20.98410397
45DDR20.96729916
46BTK0.95740533
47MAP3K130.94746616
48NLK0.92861336
49SIK30.91528949
50TAOK10.88668876
51TGFBR20.86867889
52MAP3K30.85937879
53HCK0.84607416
54EPHB20.84049814
55PRKG20.81073329
56IKBKB0.78202648
57MAPK70.75645475
58BMPR20.75427668
59RET0.74040084
60HIPK20.73261138
61LCK0.72776845
62MAP3K60.70734483
63FGR0.69796261
64LRRK20.68103616
65TGFBR10.66966696
66YES10.62024539
67LMTK20.61294042
68PDPK10.58390517
69FYN0.58351127
70MAP2K30.57174294
71DMPK0.54301498
72TESK20.50810810
73MAPKAPK20.50100956
74MAP3K110.49921372
75PDGFRB0.48116240
76PRKD20.47462695
77MAPK110.46711804
78MYLK0.45777273
79PDK10.45641022
80ITK0.44464078
81TAOK30.43422392
82MAP3K20.43059647
83CDK60.42363019
84IRAK30.40485785
85PAK40.40449830
86TNK20.37997557
87GRK50.34657682
88MAP2K20.34110695
89OXSR10.31157565
90TEC0.30098555
91PDK20.30085863
92PRKCQ0.29727258
93PRKCD0.29714446
94KSR20.29450372
95TAOK20.29289591
96SRC0.29054992
97MAPK40.28996116
98IGF1R0.28783881
99SIK10.27183431
100CHUK0.26734946

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.86506560
2Asthma_Homo sapiens_hsa053103.46603841
3Allograft rejection_Homo sapiens_hsa053303.26573686
4Autoimmune thyroid disease_Homo sapiens_hsa053203.12445471
5Graft-versus-host disease_Homo sapiens_hsa053323.03306006
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.00716660
7Leishmaniasis_Homo sapiens_hsa051402.61583239
8Type I diabetes mellitus_Homo sapiens_hsa049402.48881122
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30717647
10Antigen processing and presentation_Homo sapiens_hsa046122.24140461
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99926773
12Viral myocarditis_Homo sapiens_hsa054161.93402949
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.88148858
14Primary immunodeficiency_Homo sapiens_hsa053401.80478921
15Toxoplasmosis_Homo sapiens_hsa051451.70979131
16Pertussis_Homo sapiens_hsa051331.68903312
17Osteoclast differentiation_Homo sapiens_hsa043801.59969402
18Influenza A_Homo sapiens_hsa051641.57889518
19Tuberculosis_Homo sapiens_hsa051521.47704674
20Hematopoietic cell lineage_Homo sapiens_hsa046401.41859857
21B cell receptor signaling pathway_Homo sapiens_hsa046621.40002665
22Other glycan degradation_Homo sapiens_hsa005111.36084966
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.35168345
24Rheumatoid arthritis_Homo sapiens_hsa053231.31841604
25Complement and coagulation cascades_Homo sapiens_hsa046101.29931313
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25516537
27Herpes simplex infection_Homo sapiens_hsa051681.24967366
28Sulfur metabolism_Homo sapiens_hsa009201.23644672
29Arginine biosynthesis_Homo sapiens_hsa002201.22276267
30Renin-angiotensin system_Homo sapiens_hsa046141.13981101
31Malaria_Homo sapiens_hsa051441.13485970
32Hepatitis C_Homo sapiens_hsa051601.13343001
33TNF signaling pathway_Homo sapiens_hsa046681.13062820
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11302776
35Phagosome_Homo sapiens_hsa041451.09305330
36Measles_Homo sapiens_hsa051621.08267385
37Chemokine signaling pathway_Homo sapiens_hsa040621.04877514
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.02113289
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00350289
40Fat digestion and absorption_Homo sapiens_hsa049750.99940777
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91897317
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89449555
43African trypanosomiasis_Homo sapiens_hsa051430.89156471
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88170814
45Fructose and mannose metabolism_Homo sapiens_hsa000510.87325764
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85202183
47Protein digestion and absorption_Homo sapiens_hsa049740.85155628
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82978756
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.82826167
50Mineral absorption_Homo sapiens_hsa049780.77348039
51Acute myeloid leukemia_Homo sapiens_hsa052210.75622220
52Amoebiasis_Homo sapiens_hsa051460.75326739
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72572199
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71686661
55Caffeine metabolism_Homo sapiens_hsa002320.70609199
56Histidine metabolism_Homo sapiens_hsa003400.68464602
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68058901
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.67731859
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67068362
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66139506
61Arachidonic acid metabolism_Homo sapiens_hsa005900.65427106
62Pancreatic secretion_Homo sapiens_hsa049720.63350422
63Apoptosis_Homo sapiens_hsa042100.62322811
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60233445
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59852607
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56166685
67Salmonella infection_Homo sapiens_hsa051320.55779193
68Nitrogen metabolism_Homo sapiens_hsa009100.54990014
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54658506
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54468369
71Starch and sucrose metabolism_Homo sapiens_hsa005000.53016104
72Hepatitis B_Homo sapiens_hsa051610.53000389
73Systemic lupus erythematosus_Homo sapiens_hsa053220.52862156
74Prion diseases_Homo sapiens_hsa050200.51486637
75Pancreatic cancer_Homo sapiens_hsa052120.50524650
76T cell receptor signaling pathway_Homo sapiens_hsa046600.48003147
77Legionellosis_Homo sapiens_hsa051340.47784186
78Prolactin signaling pathway_Homo sapiens_hsa049170.47080742
79Lysosome_Homo sapiens_hsa041420.46238629
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44717440
81Platelet activation_Homo sapiens_hsa046110.43753309
82Linoleic acid metabolism_Homo sapiens_hsa005910.42844245
83PPAR signaling pathway_Homo sapiens_hsa033200.42715381
84HTLV-I infection_Homo sapiens_hsa051660.42606474
85Galactose metabolism_Homo sapiens_hsa000520.42538968
86Retinol metabolism_Homo sapiens_hsa008300.40469641
87Epstein-Barr virus infection_Homo sapiens_hsa051690.37746097
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36020947
89HIF-1 signaling pathway_Homo sapiens_hsa040660.35934139
90Chronic myeloid leukemia_Homo sapiens_hsa052200.33902165
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.32944893
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32051717
93Thyroid hormone synthesis_Homo sapiens_hsa049180.31763680
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31423696
95VEGF signaling pathway_Homo sapiens_hsa043700.31123549
96Notch signaling pathway_Homo sapiens_hsa043300.30716804
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29726133
98Shigellosis_Homo sapiens_hsa051310.29527362
99Fatty acid degradation_Homo sapiens_hsa000710.29472003
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.29356573

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