ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	B cell receptor signaling pathway (GO:0050853)	8.95628000
2	V(D)J recombination (GO:0033151)	7.25513528
3	negative regulation of thymocyte apoptotic process (GO:0070244)	6.62098051
4	B cell proliferation (GO:0042100)	6.24660572
5	T cell lineage commitment (GO:0002360)	5.74140488
6	antigen processing and presentation of endogenous antigen (GO:0019883)	5.47393223
7	positive thymic T cell selection (GO:0045059)	5.45679494
8	immunoglobulin mediated immune response (GO:0016064)	5.44022505
9	regulation of B cell receptor signaling pathway (GO:0050855)	5.16269015
10	regulation of germinal center formation (GO:0002634)	5.10958009
11	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.03547904
12	positive regulation of B cell differentiation (GO:0045579)	4.92665102
13	regulation of dendritic cell antigen processing and presentation (GO:0002604)	4.86624398
14	negative regulation of B cell apoptotic process (GO:0002903)	4.77145264
15	positive regulation of gamma-delta T cell activation (GO:0046645)	4.72721806
16	cellular response to ethanol (GO:0071361)	4.58997573
17	regulation of antigen processing and presentation (GO:0002577)	4.45473605
18	B cell mediated immunity (GO:0019724)	4.45120467
19	B cell homeostasis (GO:0001782)	4.43572101
20	regulation of B cell differentiation (GO:0045577)	4.33823832
21	negative regulation of T cell apoptotic process (GO:0070233)	4.24713202
22	positive T cell selection (GO:0043368)	4.24513671
23	T cell homeostasis (GO:0043029)	4.23363893
24	regulation of thymocyte apoptotic process (GO:0070243)	4.16364987
25	negative regulation of lymphocyte apoptotic process (GO:0070229)	4.15505049
26	mucosal-associated lymphoid tissue development (GO:0048537)	4.14387333
27	Peyers patch development (GO:0048541)	4.14387333
28	B cell differentiation (GO:0030183)	4.13359220
29	regulation of B cell proliferation (GO:0030888)	4.11800568
30	positive regulation of B cell proliferation (GO:0030890)	4.11356978
31	detection of bacterium (GO:0016045)	4.06186699
32	poly(A)+ mRNA export from nucleus (GO:0016973)	4.05764533
33	antigen receptor-mediated signaling pathway (GO:0050851)	4.02764364
34	lymphocyte homeostasis (GO:0002260)	4.02122599
35	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.96746759
36	lymphocyte proliferation (GO:0046651)	3.90692757
37	B cell activation (GO:0042113)	3.90562734
38	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.89808665
39	T cell differentiation in thymus (GO:0033077)	3.89634748
40	response to hydroperoxide (GO:0033194)	3.87908686
41	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.85581524
42	regulation of B cell apoptotic process (GO:0002902)	3.84805629
43	mononuclear cell proliferation (GO:0032943)	3.84229587
44	positive regulation of antigen processing and presentation (GO:0002579)	3.83840493
45	cellular hyperosmotic response (GO:0071474)	3.74197414
46	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.73099797
47	detection of other organism (GO:0098543)	3.71906190
48	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.70539940
49	somatic diversification of immune receptors (GO:0002200)	3.68625904
50	positive regulation of B cell activation (GO:0050871)	3.68491912
51	somatic cell DNA recombination (GO:0016444)	3.61171295
52	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	3.61171295
53	leukocyte homeostasis (GO:0001776)	3.60809124
54	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.59645357
55	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.57757471
56	leukocyte proliferation (GO:0070661)	3.50089697
57	negative thymic T cell selection (GO:0045060)	3.46241865
58	respiratory burst (GO:0045730)	3.45983001
59	negative regulation of cell killing (GO:0031342)	3.25807055
60	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.25807055
61	mast cell activation (GO:0045576)	3.23515592
62	mast cell degranulation (GO:0043303)	3.22637594
63	mast cell activation involved in immune response (GO:0002279)	3.22637594
64	thymic T cell selection (GO:0045061)	3.22524579
65	regulation of gamma-delta T cell activation (GO:0046643)	3.17665498
66	negative T cell selection (GO:0043383)	3.17198729
67	type I interferon signaling pathway (GO:0060337)	3.15077177
68	cellular response to type I interferon (GO:0071357)	3.15077177
69	germinal center formation (GO:0002467)	3.14401208
70	regulation of interferon-beta biosynthetic process (GO:0045357)	3.13579606
71	negative regulation of leukocyte apoptotic process (GO:2000107)	3.13424784
72	regulation of gamma-delta T cell differentiation (GO:0045586)	3.12512786
73	regulation of B cell activation (GO:0050864)	3.11856789
74	response to type I interferon (GO:0034340)	3.11037835
75	DNA topological change (GO:0006265)	3.08809666
76	negative regulation of T-helper cell differentiation (GO:0045623)	3.05818235
77	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	3.05818235
78	immune response-activating cell surface receptor signaling pathway (GO:0002429)	3.05580978
79	replicative senescence (GO:0090399)	2.99581982
80	negative regulation of B cell proliferation (GO:0030889)	2.99101443
81	T cell selection (GO:0045058)	2.97708948
82	positive regulation of macrophage cytokine production (GO:0060907)	2.97524421
83	positive regulation of protein homooligomerization (GO:0032464)	2.95074286
84	T cell proliferation (GO:0042098)	2.93342608
85	interferon-gamma-mediated signaling pathway (GO:0060333)	2.90006387
86	positive regulation of type 2 immune response (GO:0002830)	2.89203080
87	regulation of interferon-gamma biosynthetic process (GO:0045072)	2.88804776
88	histone monoubiquitination (GO:0010390)	2.84292530
89	regulation of lymphocyte apoptotic process (GO:0070228)	2.84028269
90	adaptive immune response (GO:0002250)	2.80729076
91	regulation of T cell apoptotic process (GO:0070232)	2.80339443
92	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.79544150
93	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.79250509
94	positive regulation of granulocyte differentiation (GO:0030854)	2.77733474
95	actin nucleation (GO:0045010)	2.77549363
96	positive regulation of immunoglobulin production (GO:0002639)	2.76540642
97	regulation of histone H3-K9 methylation (GO:0051570)	2.75876501
98	negative regulation of bone resorption (GO:0045779)	2.75551327
99	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.69787824
100	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.69261911

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	7.60591629
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.68488276
3	MYC_22102868_ChIP-Seq_BL_Human	5.05122146
4	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	4.00443984
5	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	3.82380668
6	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	3.70358011
7	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.54668324
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.16733264
9	E2F7_22180533_ChIP-Seq_HELA_Human	3.14200833
10	CIITA_25753668_ChIP-Seq_RAJI_Human	2.98821391
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.81286645
12	MYB_26560356_Chip-Seq_TH2_Human	2.67830776
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.62162130
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.48194873
15	VDR_21846776_ChIP-Seq_THP-1_Human	2.42065912
16	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.37746708
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.32717966
18	MYB_26560356_Chip-Seq_TH1_Human	2.31583001
19	VDR_24763502_ChIP-Seq_THP-1_Human	2.26418727
20	RUNX_20019798_ChIP-Seq_JUKART_Human	2.23346024
21	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.12776870
22	GATA1_22025678_ChIP-Seq_K562_Human	2.07766496
23	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.02228519
24	IRF8_27001747_Chip-Seq_BMDM_Mouse	2.01792796
25	SPI1_23547873_ChIP-Seq_NB4_Human	1.99803070
26	MAF_26560356_Chip-Seq_TH1_Human	1.98411134
27	UTX_26944678_Chip-Seq_JUKART_Human	1.96612334
28	SCL_19346495_ChIP-Seq_HPC-7_Human	1.93177719
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.92185224
30	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.87780709
31	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.87581372
32	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.82268390
33	GATA3_27048872_Chip-Seq_THYMUS_Human	1.78456877
34	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.76578070
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.73719275
36	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.72865487
37	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.71439677
38	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.71153419
39	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.67876749
40	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.60285473
41	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.57418121
42	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.54777621
43	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53665221
44	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.51072189
45	SPI1_23127762_ChIP-Seq_K562_Human	1.47867706
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45348522
47	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.45287363
48	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.45109201
49	MAF_26560356_Chip-Seq_TH2_Human	1.40539895
50	TCF7_22412390_ChIP-Seq_EML_Mouse	1.36629670
51	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.36371372
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.33927482
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.33651840
54	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.31072071
55	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.31007910
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28064906
57	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.26682243
58	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.23204223
59	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.22709495
60	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.19931667
61	BCL6_27268052_Chip-Seq_Bcells_Human	1.17861850
62	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.17529892
63	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.16841579
64	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.13183115
65	P300_27268052_Chip-Seq_Bcells_Human	1.11635388
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10043378
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09614257
68	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.09452699
69	GATA3_26560356_Chip-Seq_TH2_Human	1.08580620
70	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.07917063
71	SMRT_27268052_Chip-Seq_Bcells_Human	1.07596011
72	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.06464172
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05507447
74	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.04019358
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.01719077
76	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.01717764
77	BCOR_27268052_Chip-Seq_Bcells_Human	1.00315399
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93868820
79	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93815636
80	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.93164781
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90504144
82	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89705059
83	KDM2B_26808549_Chip-Seq_DND41_Human	0.88357204
84	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.87225031
85	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.86894194
86	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.86369872
87	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.84696214
88	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.84485237
89	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.83816315
90	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.78426436
91	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.78027882
92	RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.77323306
93	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.76301317
94	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.75923907
95	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.75907825
96	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.75058348
97	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.74863266
98	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.74783950
99	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.74587904
100	SPI1_20517297_ChIP-Seq_HL60_Human	0.73607503

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.56339668
2	MP0005387_immune_system_phenotype	4.17210276
3	MP0001790_abnormal_immune_system	4.17210276
4	MP0001800_abnormal_humoral_immune	4.12081163
5	MP0000685_abnormal_immune_system	4.11943162
6	MP0009278_abnormal_bone_marrow	4.00012699
7	MP0002132_abnormal_respiratory_system	3.92002787
8	MP0005671_abnormal_response_to	3.20915162
9	MP0005451_abnormal_body_composition	3.10543629
10	MP0003763_abnormal_thymus_physiology	3.08074502
11	MP0002166_altered_tumor_susceptibility	3.05713910
12	MP0002452_abnormal_antigen_presenting	2.99235981
13	MP0005000_abnormal_immune_tolerance	2.90618915
14	MP0009785_altered_susceptibility_to	2.75522991
15	MP0002723_abnormal_immune_serum	2.72812895
16	MP0002420_abnormal_adaptive_immunity	2.67151840
17	MP0001819_abnormal_immune_cell	2.59164348
18	MP0002398_abnormal_bone_marrow	2.58159290
19	MP0010094_abnormal_chromosome_stability	2.41246739
20	MP0000689_abnormal_spleen_morphology	2.30713332
21	MP0002148_abnormal_hypersensitivity_rea	2.26602318
22	MP0000716_abnormal_immune_system	2.25598690
23	MP0002006_tumorigenesis	2.11921143
24	MP0003436_decreased_susceptibility_to	2.10465633
25	MP0002876_abnormal_thyroid_physiology	2.06047550
26	MP0005025_abnormal_response_to	2.02022893
27	MP0003183_abnormal_peptide_metabolism	1.99012636
28	MP0001545_abnormal_hematopoietic_system	1.97678323
29	MP0005397_hematopoietic_system_phenotyp	1.97678323
30	MP0004947_skin_inflammation	1.96501422
31	MP0003303_peritoneal_inflammation	1.92038823
32	MP0002722_abnormal_immune_system	1.90537042
33	MP0002138_abnormal_hepatobiliary_system	1.89286227
34	MP0002429_abnormal_blood_cell	1.82537390
35	MP0010155_abnormal_intestine_physiology	1.72241991
36	MP0002419_abnormal_innate_immunity	1.70867764
37	MP0000703_abnormal_thymus_morphology	1.69804489
38	MP0001849_ear_inflammation	1.60014320
39	MP0008057_abnormal_DNA_replication	1.54993520
40	MP0002396_abnormal_hematopoietic_system	1.53830169
41	MP0002405_respiratory_system_inflammati	1.52572816
42	MP0005645_abnormal_hypothalamus_physiol	1.41619925
43	MP0001845_abnormal_inflammatory_respons	1.37042880
44	MP0002653_abnormal_ependyma_morphology	1.35565592
45	MP0003300_gastrointestinal_ulcer	1.31418145
46	MP0000490_abnormal_crypts_of	1.28436768
47	MP0005464_abnormal_platelet_physiology	1.25745510
48	MP0002019_abnormal_tumor_incidence	1.22831319
49	MP0000465_gastrointestinal_hemorrhage	1.21507373
50	MP0000015_abnormal_ear_pigmentation	1.18500975
51	MP0002928_abnormal_bile_duct	1.18319301
52	MP0005075_abnormal_melanosome_morpholog	1.17269995
53	MP0004808_abnormal_hematopoietic_stem	1.15030195
54	MP0003252_abnormal_bile_duct	1.11744563
55	MP0001879_abnormal_lymphatic_vessel	1.10005780
56	MP0008877_abnormal_DNA_methylation	1.08766358
57	MP0000462_abnormal_digestive_system	1.06260050
58	MP0002933_joint_inflammation	1.01598772
59	MP0004381_abnormal_hair_follicle	0.99687164
60	MP0002095_abnormal_skin_pigmentation	0.96527805
61	MP0003172_abnormal_lysosome_physiology	0.96507552
62	MP0004084_abnormal_cardiac_muscle	0.89237270
63	MP0008469_abnormal_protein_level	0.87268629
64	MP0000372_irregular_coat_pigmentation	0.86441808
65	MP0002009_preneoplasia	0.85036270
66	MP0003191_abnormal_cellular_cholesterol	0.84974643
67	MP0001853_heart_inflammation	0.84874192
68	MP0009333_abnormal_splenocyte_physiolog	0.79890884
69	MP0003077_abnormal_cell_cycle	0.78608930
70	MP0005310_abnormal_salivary_gland	0.76302756
71	MP0008872_abnormal_physiological_respon	0.71522672
72	MP0005220_abnormal_exocrine_pancreas	0.69703764
73	MP0008058_abnormal_DNA_repair	0.66825987
74	MP0002136_abnormal_kidney_physiology	0.65230592
75	MP0003724_increased_susceptibility_to	0.65088095
76	MP0001663_abnormal_digestive_system	0.63812687
77	MP0001986_abnormal_taste_sensitivity	0.62162650
78	MP0001533_abnormal_skeleton_physiology	0.61689583
79	MP0008874_decreased_physiological_sensi	0.58518342
80	MP0002163_abnormal_gland_morphology	0.58283442
81	MP0004036_abnormal_muscle_relaxation	0.56585702
82	MP0005084_abnormal_gallbladder_morpholo	0.56124408
83	MP0003866_abnormal_defecation	0.52735412
84	MP0000249_abnormal_blood_vessel	0.51033720
85	MP0002083_premature_death	0.49585766
86	MP0003045_fibrosis	0.48493329
87	MP0008007_abnormal_cellular_replicative	0.47338148
88	MP0002822_catalepsy	0.42636283
89	MP0000313_abnormal_cell_death	0.41006946
90	MP0005584_abnormal_enzyme/coenzyme_acti	0.40567069
91	MP0000470_abnormal_stomach_morphology	0.40379499
92	MP0001851_eye_inflammation	0.40370654
93	MP0001764_abnormal_homeostasis	0.40106748
94	MP0005381_digestive/alimentary_phenotyp	0.38710853
95	MP0000350_abnormal_cell_proliferation	0.38535859
96	MP0009764_decreased_sensitivity_to	0.38480792
97	MP0009697_abnormal_copulation	0.37835742
98	MP0003693_abnormal_embryo_hatching	0.37475328
99	MP0003943_abnormal_hepatobiliary_system	0.36816170
100	MP0001873_stomach_inflammation	0.33934900

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	9.70447365
2	Abnormality of B cell number (HP:0010975)	9.40028795
3	Panhypogammaglobulinemia (HP:0003139)	8.28772988
4	Severe combined immunodeficiency (HP:0004430)	7.72988586
5	Hypoplasia of the thymus (HP:0000778)	7.69374781
6	Thyroiditis (HP:0100646)	6.53259089
7	Combined immunodeficiency (HP:0005387)	6.44506548
8	Cellulitis (HP:0100658)	5.90481358
9	Meningitis (HP:0001287)	5.72295457
10	Hypoproteinemia (HP:0003075)	5.54336834
11	Verrucae (HP:0200043)	5.20452373
12	Papilloma (HP:0012740)	5.20452373
13	Gastrointestinal stroma tumor (HP:0100723)	5.18166986
14	Recurrent bronchitis (HP:0002837)	5.17546067
15	Eosinophilia (HP:0001880)	5.15746812
16	Chronic sinusitis (HP:0011109)	5.11197719
17	T lymphocytopenia (HP:0005403)	5.10366581
18	Recurrent viral infections (HP:0004429)	5.01646730
19	Recurrent pneumonia (HP:0006532)	4.94782316
20	IgG deficiency (HP:0004315)	4.84077914
21	Granulocytopenia (HP:0001913)	4.74756182
22	Sepsis (HP:0100806)	4.58148053
23	Recurrent fungal infections (HP:0002841)	4.37162879
24	Abnormality of T cell number (HP:0011839)	4.35433795
25	Osteomyelitis (HP:0002754)	4.12691102
26	Recurrent sinusitis (HP:0011108)	3.82167616
27	Abnormality of eosinophils (HP:0001879)	3.81873016
28	Recurrent lower respiratory tract infections (HP:0002783)	3.80465426
29	Aplasia/Hypoplasia of the thymus (HP:0010515)	3.53213238
30	Erythroderma (HP:0001019)	3.46626504
31	Lymphopenia (HP:0001888)	3.46061244
32	Recurrent otitis media (HP:0000403)	3.18895478
33	Lymphoma (HP:0002665)	3.17242613
34	Abnormality of T cells (HP:0002843)	3.14251142
35	Abnormality of cells of the lymphoid lineage (HP:0012140)	3.10598648
36	Vasculitis (HP:0002633)	3.01832235
37	Bronchitis (HP:0012387)	3.00837389
38	Mediastinal lymphadenopathy (HP:0100721)	2.90535008
39	Colitis (HP:0002583)	2.85742913
40	Skin rash (HP:0000988)	2.85150543
41	Leukocytosis (HP:0001974)	2.81201743
42	Eczematoid dermatitis (HP:0000976)	2.74881944
43	Abnormality of the thymus (HP:0000777)	2.63734367
44	Emphysema (HP:0002097)	2.61298689
45	Inflammation of the large intestine (HP:0002037)	2.44423142
46	Restrictive lung disease (HP:0002091)	2.38906113
47	Gastrointestinal inflammation (HP:0004386)	2.36322403
48	Abnormality of the prostate (HP:0008775)	2.35589921
49	Dehydration (HP:0001944)	2.31814195
50	IgM deficiency (HP:0002850)	2.27240403
51	Obstructive lung disease (HP:0006536)	2.22330999
52	Chronic obstructive pulmonary disease (HP:0006510)	2.22330999
53	Increased IgE level (HP:0003212)	2.21596577
54	Recurrent bacterial skin infections (HP:0005406)	2.18948039
55	Recurrent gram-negative bacterial infections (HP:0005420)	2.18544008
56	Cutaneous melanoma (HP:0012056)	2.11128365
57	IgA deficiency (HP:0002720)	2.06927693
58	Autoimmune hemolytic anemia (HP:0001890)	2.03313333
59	Recurrent abscess formation (HP:0002722)	2.02906674
60	B lymphocytopenia (HP:0010976)	10.4850182
61	Skin ulcer (HP:0200042)	1.97056052
62	Microvesicular hepatic steatosis (HP:0001414)	1.95416735
63	Stomatitis (HP:0010280)	1.84410380
64	Elevated erythrocyte sedimentation rate (HP:0003565)	1.83007461
65	Neutropenia (HP:0001875)	1.81755626
66	Prostate neoplasm (HP:0100787)	1.79196624
67	Leukopenia (HP:0001882)	1.78997486
68	Abnormality of macrophages (HP:0004311)	1.69242757
69	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.68996229
70	Encephalitis (HP:0002383)	1.67771057
71	Acute hepatic failure (HP:0006554)	1.64039917
72	Abnormality of T cell physiology (HP:0011840)	1.62314298
73	Gastrointestinal infarctions (HP:0005244)	1.61812260
74	Pulmonary infiltrates (HP:0002113)	1.56351082
75	Hypertensive crisis (HP:0100735)	1.53397295
76	Basal cell carcinoma (HP:0002671)	1.51930934
77	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.51616487
78	Abnormality of male internal genitalia (HP:0000022)	1.51457709
79	Acute lymphatic leukemia (HP:0006721)	1.51039961
80	Squamous cell carcinoma (HP:0002860)	1.49401286
81	Abnormality of the pleura (HP:0002103)	1.48155088
82	Urticaria (HP:0001025)	1.44984906
83	Cellular immunodeficiency (HP:0005374)	1.44421107
84	Lower limb hyperreflexia (HP:0002395)	1.40477730
85	Pulmonary fibrosis (HP:0002206)	1.38630140
86	Recurrent skin infections (HP:0001581)	1.37635569
87	External ear malformation (HP:0008572)	1.37330304
88	Abnormality of the peritoneum (HP:0002585)	1.37132283
89	Recurrent cutaneous fungal infections (HP:0011370)	1.35870931
90	Chronic mucocutaneous candidiasis (HP:0002728)	1.35870931
91	Poikiloderma (HP:0001029)	1.33406087
92	Xerostomia (HP:0000217)	1.31835815
93	Autoimmune thrombocytopenia (HP:0001973)	1.31290822
94	Testicular atrophy (HP:0000029)	1.30857556
95	Purpura (HP:0000979)	1.28364183
96	Arthralgia (HP:0002829)	1.28284930
97	Chest pain (HP:0100749)	1.25894880
98	Elevated hepatic transaminases (HP:0002910)	1.25208997
99	Viral hepatitis (HP:0006562)	1.24847873
100	Increased IgM level (HP:0003496)	1.24017445

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.17222865
2	MAP4K1	3.97062047
3	RIPK4	3.38789271
4	MAP3K10	3.11163441
5	SYK	3.09185692
6	MAP3K13	2.92831828
7	IRAK4	2.85478904
8	BTK	2.77046719
9	BLK	2.62722647
10	KIT	2.25925651
11	BMPR2	2.17992841
12	CSF1R	2.12671335
13	GRK6	2.11230331
14	TESK2	2.11025029
15	LYN	1.99056068
16	TYK2	1.96455620
17	PIK3CG	1.93137786
18	EIF2AK3	1.88689972
19	MAPK11	1.81494250
20	TAF1	1.79567761
21	MAP3K14	1.75985465
22	SMG1	1.73536957
23	VRK2	1.71952348
24	FES	1.70581005
25	VRK1	1.50627422
26	PRPF4B	1.44960387
27	MAPK12	1.37022592
28	TEC	1.30636760
29	TLK1	1.29114285
30	MAP3K11	1.24632689
31	KDR	1.18734608
32	ARAF	1.17232500
33	HCK	1.15504727
34	MST4	1.09917302
35	PRKD2	1.06858275
36	IKBKB	1.06708233
37	CDK8	1.02170996
38	ITK	1.01088977
39	BRSK2	0.98979687
40	TNK2	0.96323898
41	NUAK1	0.90596486
42	IKBKE	0.87494830
43	MAPK13	0.83582657
44	DAPK3	0.79947550
45	PASK	0.79714862
46	LCK	0.78608463
47	CDK12	0.77902382
48	ATR	0.76311174
49	TAOK3	0.75426154
50	PIM1	0.74313128
51	NLK	0.73684717
52	FLT3	0.73391609
53	TBK1	0.73136904
54	TAOK2	0.71359406
55	RPS6KB1	0.71326430
56	CDK9	0.70032482
57	CDK4	0.66839289
58	MAPK4	0.62624029
59	NEK9	0.61977386
60	RPS6KA5	0.60652344
61	SIK3	0.60195766
62	ZAK	0.59884674
63	BRSK1	0.59846712
64	RPS6KB2	0.59580053
65	MAP2K3	0.58129803
66	DAPK1	0.57819210
67	PRKCQ	0.57179768
68	JAK3	0.56918267
69	PRKCH	0.56360447
70	MET	0.54733661
71	BCKDK	0.53100376
72	PIM2	0.52232745
73	BMPR1B	0.50794261
74	RPS6KC1	0.49588148
75	RPS6KL1	0.49588148
76	SIK2	0.49239748
77	PINK1	0.47963950
78	PRKCI	0.46844476
79	MARK3	0.46417676
80	CDK7	0.44114287
81	CSK	0.44059941
82	STK10	0.43790344
83	STK11	0.43045774
84	PDK1	0.42534225
85	RPS6KA6	0.40806005
86	BRAF	0.40549062
87	TAOK1	0.40379748
88	AURKA	0.39355324
89	FYN	0.38786458
90	MAPKAPK2	0.37920644
91	RPS6KA4	0.37809733
92	HIPK2	0.37491132
93	ABL1	0.37238989
94	MAP3K7	0.35530651
95	EEF2K	0.34363730
96	JAK2	0.32038879
97	MAP3K8	0.31773058
98	ZAP70	0.30996192
99	TGFBR1	0.30150076
100	MAP3K1	0.28874081

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	7.42087895
2	Non-homologous end-joining_Homo sapiens_hsa03450	4.63340953
3	B cell receptor signaling pathway_Homo sapiens_hsa04662	4.38047262
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.84459439
5	Allograft rejection_Homo sapiens_hsa05330	3.62384036
6	Asthma_Homo sapiens_hsa05310	3.58980995
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.44800445
8	Graft-versus-host disease_Homo sapiens_hsa05332	3.29141432
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.75282503
10	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.59201603
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.30007846
12	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.13444234
13	Leishmaniasis_Homo sapiens_hsa05140	2.09204494
14	Viral myocarditis_Homo sapiens_hsa05416	2.00329739
15	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.94750083
16	DNA replication_Homo sapiens_hsa03030	1.93828546
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.87207885
18	Herpes simplex infection_Homo sapiens_hsa05168	1.59060508
19	Base excision repair_Homo sapiens_hsa03410	1.52563766
20	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.49651775
21	Mismatch repair_Homo sapiens_hsa03430	1.28878268
22	Alcoholism_Homo sapiens_hsa05034	1.15417593
23	Tuberculosis_Homo sapiens_hsa05152	1.11157691
24	HTLV-I infection_Homo sapiens_hsa05166	1.10229476
25	Osteoclast differentiation_Homo sapiens_hsa04380	1.09616819
26	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.09229353
27	Influenza A_Homo sapiens_hsa05164	1.05075973
28	Toxoplasmosis_Homo sapiens_hsa05145	1.04057538
29	Viral carcinogenesis_Homo sapiens_hsa05203	1.02280639
30	Measles_Homo sapiens_hsa05162	0.92157251
31	Homologous recombination_Homo sapiens_hsa03440	0.90851045
32	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86838977
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82865373
34	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73875081
35	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.71803738
36	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71266429
37	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.70530905
38	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68343414
39	Caffeine metabolism_Homo sapiens_hsa00232	0.65113385
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.60228699
41	Hepatitis B_Homo sapiens_hsa05161	0.59693662
42	Proteasome_Homo sapiens_hsa03050	0.58901485
43	Non-small cell lung cancer_Homo sapiens_hsa05223	0.57446161
44	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.56441882
45	FoxO signaling pathway_Homo sapiens_hsa04068	0.56147443
46	Acute myeloid leukemia_Homo sapiens_hsa05221	0.55456538
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49390283
48	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.46404079
49	Chemokine signaling pathway_Homo sapiens_hsa04062	0.45640094
50	Phagosome_Homo sapiens_hsa04145	0.44212301
51	Apoptosis_Homo sapiens_hsa04210	0.43396786
52	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43050027
53	Shigellosis_Homo sapiens_hsa05131	0.39437999
54	Hepatitis C_Homo sapiens_hsa05160	0.37560141
55	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.34643889
56	RNA degradation_Homo sapiens_hsa03018	0.33892599
57	Platelet activation_Homo sapiens_hsa04611	0.32841703
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.32342464
59	One carbon pool by folate_Homo sapiens_hsa00670	0.31803565
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.30283648
61	African trypanosomiasis_Homo sapiens_hsa05143	0.30125082
62	Pancreatic cancer_Homo sapiens_hsa05212	0.27814562
63	Sulfur relay system_Homo sapiens_hsa04122	0.27498687
64	Cell cycle_Homo sapiens_hsa04110	0.27439780
65	Malaria_Homo sapiens_hsa05144	0.27346913
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.27073859
67	TNF signaling pathway_Homo sapiens_hsa04668	0.26985816
68	Fatty acid elongation_Homo sapiens_hsa00062	0.26605212
69	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.24356814
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24063827
71	Spliceosome_Homo sapiens_hsa03040	0.22439589
72	p53 signaling pathway_Homo sapiens_hsa04115	0.21217390
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.20511999
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19186047
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.18644110
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.18523608
77	Insulin resistance_Homo sapiens_hsa04931	0.15501291
78	Small cell lung cancer_Homo sapiens_hsa05222	0.15205952
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.15159753
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.14721771
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.14089488
82	Sulfur metabolism_Homo sapiens_hsa00920	0.12633700
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.11501614
84	Prostate cancer_Homo sapiens_hsa05215	0.11099656
85	RNA polymerase_Homo sapiens_hsa03020	0.09668165
86	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.09332102
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.08581513
88	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.07876994
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.07155610
90	Purine metabolism_Homo sapiens_hsa00230	0.06986399
91	Renal cell carcinoma_Homo sapiens_hsa05211	0.06037168
92	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.04650800
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.03229439
94	Legionellosis_Homo sapiens_hsa05134	0.00541193
95	RNA transport_Homo sapiens_hsa03013	0.00459477
96	Prolactin signaling pathway_Homo sapiens_hsa04917	0.00256916
97	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.0256482
98	mTOR signaling pathway_Homo sapiens_hsa04150	-0.0252029
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	-0.0192583
100	Colorectal cancer_Homo sapiens_hsa05210	-0.0155018

IGHV5-78

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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