IGIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.28677567
2synaptic vesicle exocytosis (GO:0016079)5.19183460
3vocalization behavior (GO:0071625)5.02006231
4neuronal action potential propagation (GO:0019227)4.96240794
5neuron cell-cell adhesion (GO:0007158)4.78057391
6sodium ion export (GO:0071436)4.73917809
7glutamate secretion (GO:0014047)4.69428030
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64659333
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59368773
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55690604
11regulation of synaptic vesicle exocytosis (GO:2000300)4.53283309
12locomotory exploration behavior (GO:0035641)4.48986572
13synaptic vesicle maturation (GO:0016188)4.44718038
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.34777385
15neurotransmitter secretion (GO:0007269)4.25814862
16regulation of glutamate receptor signaling pathway (GO:1900449)4.24619806
17protein localization to synapse (GO:0035418)4.23819050
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.20214871
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.19393319
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10394047
21regulation of synaptic vesicle transport (GO:1902803)4.09014836
22glutamate receptor signaling pathway (GO:0007215)4.05831398
23potassium ion homeostasis (GO:0055075)4.05178683
24neuron-neuron synaptic transmission (GO:0007270)3.90503425
25potassium ion import (GO:0010107)3.83414537
26gamma-aminobutyric acid transport (GO:0015812)3.83158223
27presynaptic membrane assembly (GO:0097105)3.79622084
28regulation of ARF protein signal transduction (GO:0032012)3.79317879
29L-amino acid import (GO:0043092)3.78125797
30synaptic transmission, glutamatergic (GO:0035249)3.76759871
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76443405
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.72544909
33exploration behavior (GO:0035640)3.70321991
34regulation of neuronal synaptic plasticity (GO:0048168)3.65855587
35neurotransmitter transport (GO:0006836)3.62347591
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.54241905
37presynaptic membrane organization (GO:0097090)3.53654789
38long-term synaptic potentiation (GO:0060291)3.53300793
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53129285
40neuron recognition (GO:0008038)3.52261876
41neurotransmitter-gated ion channel clustering (GO:0072578)3.51084781
42transmission of nerve impulse (GO:0019226)3.51081667
43negative regulation of dendrite morphogenesis (GO:0050774)3.49699580
44mating behavior (GO:0007617)3.49182277
45central nervous system myelination (GO:0022010)3.48807394
46axon ensheathment in central nervous system (GO:0032291)3.48807394
47response to histamine (GO:0034776)3.46823301
48regulation of vesicle fusion (GO:0031338)3.45209941
49detection of calcium ion (GO:0005513)3.44835719
50cell communication by electrical coupling (GO:0010644)3.41157975
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40463706
52regulation of postsynaptic membrane potential (GO:0060078)3.40198544
53regulation of neurotransmitter levels (GO:0001505)3.38846452
54cellular potassium ion homeostasis (GO:0030007)3.38080855
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34793249
56long-term memory (GO:0007616)3.34754695
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33934136
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33066263
59cellular sodium ion homeostasis (GO:0006883)3.29039388
60proline transport (GO:0015824)3.20108328
61positive regulation of membrane potential (GO:0045838)3.18701855
62postsynaptic membrane organization (GO:0001941)3.17397188
63negative regulation of neurotransmitter transport (GO:0051589)3.16127382
64positive regulation of dendritic spine development (GO:0060999)3.15970782
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.15865191
66regulation of neurotransmitter secretion (GO:0046928)3.15358657
67regulation of synaptic plasticity (GO:0048167)3.13810911
68activation of protein kinase A activity (GO:0034199)3.13778480
69behavioral response to cocaine (GO:0048148)3.13648572
70amino acid import (GO:0043090)3.12795431
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11545242
72neuromuscular process controlling posture (GO:0050884)3.10631943
73cerebellar granule cell differentiation (GO:0021707)3.09082358
74regulation of cell communication by electrical coupling (GO:0010649)3.08042498
75regulation of dendritic spine development (GO:0060998)3.07537308
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07472274
77synaptic vesicle endocytosis (GO:0048488)3.06670611
78neuronal ion channel clustering (GO:0045161)3.06513378
79synapse assembly (GO:0007416)3.05958498
80chemosensory behavior (GO:0007635)3.05496245
81positive regulation of synapse maturation (GO:0090129)3.05487474
82membrane depolarization (GO:0051899)3.04203842
83membrane hyperpolarization (GO:0060081)3.03552264
84regulation of glutamate secretion (GO:0014048)3.01648247
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.00134427
86regulation of neurotransmitter transport (GO:0051588)2.98944808
87regulation of synapse structural plasticity (GO:0051823)2.98802662
88layer formation in cerebral cortex (GO:0021819)2.97420575
89neurotransmitter uptake (GO:0001504)2.96682772
90cerebellar Purkinje cell differentiation (GO:0021702)2.95305578
91cell communication involved in cardiac conduction (GO:0086065)2.95159902
92synaptic transmission (GO:0007268)2.94357287
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93165638
94axonal fasciculation (GO:0007413)2.92935389
95membrane depolarization during action potential (GO:0086010)2.90959121
96regulation of dendritic spine morphogenesis (GO:0061001)2.90182263
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86680962
98regulation of voltage-gated calcium channel activity (GO:1901385)2.86089926
99positive regulation of synapse assembly (GO:0051965)2.84127895
100positive regulation of neurotransmitter transport (GO:0051590)2.83518479
101fear response (GO:0042596)2.83265552
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82762413
103ATP hydrolysis coupled proton transport (GO:0015991)2.82762413
104social behavior (GO:0035176)2.82572618
105intraspecies interaction between organisms (GO:0051703)2.82572618
106positive regulation of synaptic transmission (GO:0050806)2.82514705
107striatum development (GO:0021756)2.82226895
108learning (GO:0007612)2.81370780
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80777113
110startle response (GO:0001964)2.80561871
111positive regulation of neurotransmitter secretion (GO:0001956)2.78436210
112regulation of protein kinase A signaling (GO:0010738)2.78252001
113adult walking behavior (GO:0007628)2.77766025
114regulation of synapse maturation (GO:0090128)2.77458895
115regulation of synaptic transmission (GO:0050804)2.76633708
116synapse organization (GO:0050808)2.76380275
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.76268147
118positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76252506
119dendritic spine morphogenesis (GO:0060997)2.76179798
120establishment of synaptic vesicle localization (GO:0097480)2.75972846
121synaptic vesicle transport (GO:0048489)2.75972846
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75523127
123behavioral fear response (GO:0001662)2.75423343
124behavioral defense response (GO:0002209)2.75423343
125neuromuscular process controlling balance (GO:0050885)2.74002175
126signal release (GO:0023061)2.72911917
127positive regulation of Rap GTPase activity (GO:0032854)2.70916136
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.70214856
129negative regulation of hormone biosynthetic process (GO:0032353)2.69759666
130regulation of exocytosis (GO:0017157)2.60779915
131regulation of beta-amyloid formation (GO:1902003)2.60189308
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59977312
133regulation of sodium ion transmembrane transporter activity (GO:2000649)2.59646847
134relaxation of cardiac muscle (GO:0055119)2.59241329
135cardiac conduction (GO:0061337)2.56374641
136insulin secretion (GO:0030073)2.56141770
137myelin maintenance (GO:0043217)2.53519686
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.53308629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71481341
2GBX2_23144817_ChIP-Seq_PC3_Human3.78187113
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09080714
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05010399
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90634890
6TAF15_26573619_Chip-Seq_HEK293_Human2.62364146
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59706536
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52221729
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52221729
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49263302
11REST_21632747_ChIP-Seq_MESCs_Mouse2.49189179
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45200463
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44199806
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42398858
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38403559
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.27901486
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.19170012
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.14899814
19DROSHA_22980978_ChIP-Seq_HELA_Human2.07606045
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04668300
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03410405
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.01869121
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97632560
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.96851326
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.91644536
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89732992
27AR_21572438_ChIP-Seq_LNCaP_Human1.89498176
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85983597
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84031621
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83588879
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82860810
32SMAD4_21799915_ChIP-Seq_A2780_Human1.80842494
33P300_19829295_ChIP-Seq_ESCs_Human1.73547016
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66313129
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64807908
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60370585
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59629107
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59207750
39ZNF274_21170338_ChIP-Seq_K562_Hela1.58189411
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57507405
41VDR_22108803_ChIP-Seq_LS180_Human1.56393037
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55426073
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.54599801
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52154238
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.45599313
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45290491
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43853915
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43418384
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40891077
50AR_25329375_ChIP-Seq_VCAP_Human1.40623138
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40558647
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39227780
53FUS_26573619_Chip-Seq_HEK293_Human1.39179698
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33753235
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33247954
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.32955656
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29973303
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.28582152
59IGF1R_20145208_ChIP-Seq_DFB_Human1.28153962
60STAT3_23295773_ChIP-Seq_U87_Human1.26180772
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.25709553
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23328248
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22826326
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22642044
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20897685
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.20762684
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19925486
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.19815689
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.19475476
70BCAT_22108803_ChIP-Seq_LS180_Human1.18144709
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17530513
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17484963
73RNF2_27304074_Chip-Seq_NSC_Mouse1.16909154
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13575994
75RUNX2_22187159_ChIP-Seq_PCA_Human1.13067828
76ER_23166858_ChIP-Seq_MCF-7_Human1.12827858
77TCF4_23295773_ChIP-Seq_U87_Human1.11693929
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.11501918
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10906209
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09373219
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09271317
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07519010
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.07157855
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06083456
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.05616146
86AR_19668381_ChIP-Seq_PC3_Human1.05309783
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02781767
88TP53_18474530_ChIP-ChIP_U2OS_Human1.02113631
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.01370529
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.01089209
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99305782
92AHR_22903824_ChIP-Seq_MCF-7_Human0.98098539
93JUN_21703547_ChIP-Seq_K562_Human0.97680526
94TET1_21490601_ChIP-Seq_MESCs_Mouse0.97524602
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97367088
96TP53_16413492_ChIP-PET_HCT116_Human0.97366077
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96884920
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96549605
99KDM2B_26808549_Chip-Seq_K562_Human0.96330583
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96114522
101WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95535389
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95453552
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94863092
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91971701
105KDM2B_26808549_Chip-Seq_REH_Human0.91782121
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91403320
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91325121
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89655826
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89477448
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89268648
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89268648
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88978569
113SMAD4_21741376_ChIP-Seq_EPCs_Human0.88617379
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.88082636
115RXR_22108803_ChIP-Seq_LS180_Human0.87988471
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87772974
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.87673231
118FOXA2_19822575_ChIP-Seq_HepG2_Human0.87621231
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87577661
120P53_22387025_ChIP-Seq_ESCs_Mouse0.87455975
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.87249921
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.87216205
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87068311
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86777349
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85912390
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84804132
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84804132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.20130340
2MP0003880_abnormal_central_pattern5.09936896
3MP0003635_abnormal_synaptic_transmissio3.87866167
4MP0009745_abnormal_behavioral_response3.39244375
5MP0009046_muscle_twitch3.29711964
6MP0004270_analgesia3.29329181
7MP0002064_seizures3.24859798
8MP0001968_abnormal_touch/_nociception3.14732930
9MP0002063_abnormal_learning/memory/cond3.00089082
10MP0002272_abnormal_nervous_system2.79220777
11MP0002572_abnormal_emotion/affect_behav2.75672017
12MP0002736_abnormal_nociception_after2.64240508
13MP0001501_abnormal_sleep_pattern2.61912482
14MP0001486_abnormal_startle_reflex2.56714785
15MP0002734_abnormal_mechanical_nocicepti2.54161532
16MP0002822_catalepsy2.50411782
17MP0001440_abnormal_grooming_behavior2.33363508
18MP0005423_abnormal_somatic_nervous2.28086325
19MP0002735_abnormal_chemical_nociception2.25598645
20MP0002067_abnormal_sensory_capabilities2.12708586
21MP0006276_abnormal_autonomic_nervous2.07707295
22MP0002733_abnormal_thermal_nociception1.99851322
23MP0001970_abnormal_pain_threshold1.95591377
24MP0001529_abnormal_vocalization1.92449462
25MP0005386_behavior/neurological_phenoty1.90153136
26MP0004924_abnormal_behavior1.90153136
27MP0001905_abnormal_dopamine_level1.84730012
28MP0009780_abnormal_chondrocyte_physiolo1.84616433
29MP0003329_amyloid_beta_deposits1.79283870
30MP0002184_abnormal_innervation1.71782449
31MP0004142_abnormal_muscle_tone1.69944723
32MP0001984_abnormal_olfaction1.69880337
33MP0008569_lethality_at_weaning1.69802683
34MP0002557_abnormal_social/conspecific_i1.67247670
35MP0002909_abnormal_adrenal_gland1.62075705
36MP0002837_dystrophic_cardiac_calcinosis1.56634365
37MP0005646_abnormal_pituitary_gland1.54120652
38MP0001188_hyperpigmentation1.49131536
39MP0000778_abnormal_nervous_system1.48998635
40MP0000569_abnormal_digit_pigmentation1.47665149
41MP0004145_abnormal_muscle_electrophysio1.41332113
42MP0002066_abnormal_motor_capabilities/c1.38785577
43MP0000955_abnormal_spinal_cord1.36867827
44MP0003879_abnormal_hair_cell1.36636450
45MP0004811_abnormal_neuron_physiology1.32690843
46MP0001502_abnormal_circadian_rhythm1.30337374
47MP0003122_maternal_imprinting1.29400566
48MP0000013_abnormal_adipose_tissue1.29190970
49MP0004885_abnormal_endolymph1.28106121
50MP0010234_abnormal_vibrissa_follicle1.27906867
51MP0010386_abnormal_urinary_bladder1.27862130
52MP0003633_abnormal_nervous_system1.27617389
53MP0002882_abnormal_neuron_morphology1.26839605
54MP0003123_paternal_imprinting1.25904739
55MP0003283_abnormal_digestive_organ1.23282327
56MP0003172_abnormal_lysosome_physiology1.20990990
57MP0005645_abnormal_hypothalamus_physiol1.19286584
58MP0005535_abnormal_body_temperature1.16448899
59MP0004130_abnormal_muscle_cell1.14617931
60MP0004858_abnormal_nervous_system1.13560696
61MP0004742_abnormal_vestibular_system1.13477597
62MP0002876_abnormal_thyroid_physiology1.10768510
63MP0005551_abnormal_eye_electrophysiolog1.10548239
64MP0004510_myositis1.10468142
65MP0008872_abnormal_physiological_respon1.08604636
66MP0002229_neurodegeneration1.07783884
67MP0003631_nervous_system_phenotype1.07757710
68MP0003045_fibrosis1.01993288
69MP0003787_abnormal_imprinting1.01679560
70MP0004043_abnormal_pH_regulation1.00919836
71MP0000920_abnormal_myelination0.99034781
72MP0003690_abnormal_glial_cell0.98784613
73MP0008874_decreased_physiological_sensi0.97016279
74MP0000751_myopathy0.94998105
75MP0003183_abnormal_peptide_metabolism0.94549682
76MP0005167_abnormal_blood-brain_barrier0.91225117
77MP0002152_abnormal_brain_morphology0.89521297
78MP0001963_abnormal_hearing_physiology0.89324867
79MP0004085_abnormal_heartbeat0.88934991
80MP0002069_abnormal_eating/drinking_beha0.88815587
81MP0004484_altered_response_of0.87741983
82MP0000604_amyloidosis0.86997712
83MP0005409_darkened_coat_color0.86340969
84MP0000003_abnormal_adipose_tissue0.85474843
85MP0003634_abnormal_glial_cell0.85089109
86MP0004215_abnormal_myocardial_fiber0.84622350
87MP0001664_abnormal_digestion0.82968739
88MP0010329_abnormal_lipoprotein_level0.82311221
89MP0001944_abnormal_pancreas_morphology0.82204913
90MP0002078_abnormal_glucose_homeostasis0.81504674
91MP0001177_atelectasis0.80060423
92MP0002090_abnormal_vision0.79731579
93MP0001986_abnormal_taste_sensitivity0.78989141
94MP0001485_abnormal_pinna_reflex0.77438804
95MP0003632_abnormal_nervous_system0.76893379
96MP0002971_abnormal_brown_adipose0.72974252
97MP0002752_abnormal_somatic_nervous0.72129560
98MP0005379_endocrine/exocrine_gland_phen0.70268731
99MP0000631_abnormal_neuroendocrine_gland0.70051238
100MP0004036_abnormal_muscle_relaxation0.69766473
101MP0002693_abnormal_pancreas_physiology0.69283671
102MP0006072_abnormal_retinal_apoptosis0.67814718
103MP0003195_calcinosis0.67785195
104MP0001958_emphysema0.65764793
105MP0000639_abnormal_adrenal_gland0.63714295
106MP0001765_abnormal_ion_homeostasis0.63555223
107MP0008877_abnormal_DNA_methylation0.63340162
108MP0005166_decreased_susceptibility_to0.63255986
109MP0001756_abnormal_urination0.62402616
110MP0002638_abnormal_pupillary_reflex0.61939329
111MP0005394_taste/olfaction_phenotype0.61619448
112MP0005499_abnormal_olfactory_system0.61619448
113MP0003137_abnormal_impulse_conducting0.61341565
114MP0005171_absent_coat_pigmentation0.60516532
115MP0000747_muscle_weakness0.58247861
116MP0001943_abnormal_respiration0.57105049
117MP0006035_abnormal_mitochondrial_morpho0.54633971
118MP0000230_abnormal_systemic_arterial0.52231579
119MP0000026_abnormal_inner_ear0.49612022
120MP0003075_altered_response_to0.48458004
121MP0005623_abnormal_meninges_morphology0.48263947

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.18955983
2Atonic seizures (HP:0010819)5.69946635
3Focal seizures (HP:0007359)5.67356319
4Myokymia (HP:0002411)5.48924197
5Visual hallucinations (HP:0002367)5.11971261
6Absence seizures (HP:0002121)4.82866450
7Epileptic encephalopathy (HP:0200134)4.79692660
8Febrile seizures (HP:0002373)4.44929874
9Dialeptic seizures (HP:0011146)4.39439634
10Progressive cerebellar ataxia (HP:0002073)4.13536297
11Hyperventilation (HP:0002883)4.13343657
12Generalized tonic-clonic seizures (HP:0002069)3.99558785
13Broad-based gait (HP:0002136)3.62856341
14Bundle branch block (HP:0011710)3.60046248
15Ventricular fibrillation (HP:0001663)3.38456496
16Increased circulating renin level (HP:0000848)3.35139007
17Action tremor (HP:0002345)3.19169851
18Scanning speech (HP:0002168)3.19131379
19Gaze-evoked nystagmus (HP:0000640)3.15683156
20Obstructive sleep apnea (HP:0002870)3.09296808
21Anxiety (HP:0000739)3.07315087
22Dysdiadochokinesis (HP:0002075)3.01723262
23Dysmetria (HP:0001310)2.99909613
24Pheochromocytoma (HP:0002666)2.99851371
25Supranuclear gaze palsy (HP:0000605)2.99175757
26Poor eye contact (HP:0000817)2.98431594
27Progressive inability to walk (HP:0002505)2.91806059
28Amblyopia (HP:0000646)2.91545104
29Hemiplegia (HP:0002301)2.85571048
30Truncal ataxia (HP:0002078)2.85259960
31Akinesia (HP:0002304)2.82603503
32Limb dystonia (HP:0002451)2.79922358
33Impaired social interactions (HP:0000735)2.79814587
34Abnormal social behavior (HP:0012433)2.79814587
35Tetraplegia (HP:0002445)2.74764948
36Neuroendocrine neoplasm (HP:0100634)2.73494002
37Abnormal eating behavior (HP:0100738)2.73418856
38Depression (HP:0000716)2.73369445
39Neurofibrillary tangles (HP:0002185)2.70713387
40Cerebral inclusion bodies (HP:0100314)2.70688459
41Syncope (HP:0001279)2.60735912
42Drooling (HP:0002307)2.59814960
43Excessive salivation (HP:0003781)2.59814960
44Epileptiform EEG discharges (HP:0011182)2.56192725
45Status epilepticus (HP:0002133)2.54995787
46Impaired vibration sensation in the lower limbs (HP:0002166)2.54028089
47Rigidity (HP:0002063)2.49979596
48Hyperinsulinemic hypoglycemia (HP:0000825)2.47923912
49Absent speech (HP:0001344)2.45135821
50Abnormality of binocular vision (HP:0011514)2.44505861
51Diplopia (HP:0000651)2.44505861
52Abnormal EKG (HP:0003115)2.42375555
53EEG with generalized epileptiform discharges (HP:0011198)2.42101968
54Hypoglycemic seizures (HP:0002173)2.41609470
55Papilledema (HP:0001085)2.39515982
56Inability to walk (HP:0002540)2.38756305
57Generalized myoclonic seizures (HP:0002123)2.37416736
58Prolonged QT interval (HP:0001657)2.36224415
59Heart block (HP:0012722)2.34492663
60Gait imbalance (HP:0002141)2.31659126
61Intention tremor (HP:0002080)2.31581810
62Blue irides (HP:0000635)2.30461162
63Hemiparesis (HP:0001269)2.27187543
64Hyporeflexia of lower limbs (HP:0002600)2.26614623
65Ankle clonus (HP:0011448)2.26248852
66Psychosis (HP:0000709)2.25975046
67Acute necrotizing encephalopathy (HP:0006965)2.25196808
68Craniofacial dystonia (HP:0012179)2.24257960
69Urinary bladder sphincter dysfunction (HP:0002839)2.24175898
70Hypsarrhythmia (HP:0002521)2.21857815
71Impaired smooth pursuit (HP:0007772)2.21746588
72Postural instability (HP:0002172)2.21463534
73Spastic gait (HP:0002064)2.21178012
74Lower limb muscle weakness (HP:0007340)2.20065650
75Agitation (HP:0000713)2.16864117
76Neuronal loss in central nervous system (HP:0002529)2.16758219
77Sudden death (HP:0001699)2.15953021
78Abnormal atrioventricular conduction (HP:0005150)2.15810970
79Fetal akinesia sequence (HP:0001989)2.14221246
80Postural tremor (HP:0002174)2.14128132
81Termporal pattern (HP:0011008)2.14085066
82Insidious onset (HP:0003587)2.14085066
83Insulin-resistant diabetes mellitus (HP:0000831)2.13336725
84Genetic anticipation (HP:0003743)2.13040928
85Progressive macrocephaly (HP:0004481)2.12411895
86Protruding tongue (HP:0010808)2.10109649
87Abnormal mitochondria in muscle tissue (HP:0008316)2.09296971
88Abnormality of the corticospinal tract (HP:0002492)2.08904317
89Polyphagia (HP:0002591)2.07908507
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.07513301
91Absent/shortened dynein arms (HP:0200106)2.07513301
92Stereotypic behavior (HP:0000733)2.06227375
93Congenital primary aphakia (HP:0007707)2.06111181
94Bradykinesia (HP:0002067)2.06056451
95Fair hair (HP:0002286)2.05657709
96Abnormal ciliary motility (HP:0012262)2.05361108
97Hypoglycemic coma (HP:0001325)2.03896442
98Metaphyseal dysplasia (HP:0100255)2.03813199
99Spastic tetraparesis (HP:0001285)2.03648763
100Hyperglycemia (HP:0003074)2.03351405
101Urinary urgency (HP:0000012)2.03151465
102Ventricular arrhythmia (HP:0004308)2.02512815
103Clonus (HP:0002169)2.02408035
104Annular pancreas (HP:0001734)2.02242519
105Medial flaring of the eyebrow (HP:0010747)2.01561289
106Generalized hypopigmentation of hair (HP:0011358)2.01278659
107Abnormal hair whorl (HP:0010721)1.99174647
108Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99087006
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.98163223
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98163223
111Gait ataxia (HP:0002066)1.97684598
112Sleep apnea (HP:0010535)1.97360948
113Diminished movement (HP:0002374)1.95023345
114Mutism (HP:0002300)1.94625104
115Torticollis (HP:0000473)1.93500641
116Failure to thrive in infancy (HP:0001531)1.92694766
117Abnormality of saccadic eye movements (HP:0000570)1.91649759
118Retinal dysplasia (HP:0007973)1.91546524
119Abnormality of ocular smooth pursuit (HP:0000617)1.91096833
120Impaired vibratory sensation (HP:0002495)1.90971323
121Dysmetric saccades (HP:0000641)1.90966486
122Clumsiness (HP:0002312)1.89456378
123Focal dystonia (HP:0004373)1.88463116
124Ketoacidosis (HP:0001993)1.88248350
125Nephrogenic diabetes insipidus (HP:0009806)1.87071882
126Apathy (HP:0000741)1.86946342
127Rapidly progressive (HP:0003678)1.85601310
128Cerebral hemorrhage (HP:0001342)1.85389156
129Specific learning disability (HP:0001328)1.84950857
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83381315
131Genital tract atresia (HP:0001827)1.83324385
132Abnormality of salivation (HP:0100755)1.83225533
133Hypothermia (HP:0002045)1.81770278
134Acute encephalopathy (HP:0006846)1.81670512
135Vaginal atresia (HP:0000148)1.81023817
136Resting tremor (HP:0002322)1.80935349
137Delusions (HP:0000746)1.80720090
138Thickened helices (HP:0000391)1.80564869
139Difficulty running (HP:0009046)1.80524057
140Choreoathetosis (HP:0001266)1.79841994
141Exercise-induced myalgia (HP:0003738)1.79580628
142Heterochromia iridis (HP:0001100)1.79322944
143Atrial fibrillation (HP:0005110)1.78881041
144Cerebral hypomyelination (HP:0006808)1.78188285
145Atrioventricular block (HP:0001678)1.76103869
146Menstrual irregularities (HP:0000858)1.75773097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.26293398
2EPHA43.90902732
3MAP3K93.08332839
4MAP3K122.91595121
5MAP3K42.84079372
6MAP2K72.71201974
7CASK2.60728696
8PNCK2.50701918
9RIPK42.47195414
10MINK12.34365793
11MAP2K42.16087825
12DAPK22.07599204
13KSR21.90275037
14TNIK1.86553327
15NTRK11.83948365
16MARK11.83259564
17GRK51.83145080
18CDK191.74666553
19FRK1.73865027
20PLK21.71901677
21PAK61.67772497
22OXSR11.64753361
23NTRK21.62118890
24FGFR21.59958411
25ARAF1.59642507
26BMPR21.55629788
27LATS21.50350094
28CDK51.39179341
29STK391.38109663
30MAP3K131.31446513
31DAPK11.28508528
32CAMKK21.26853785
33MAP3K21.25883073
34RIPK11.25554914
35CAMKK11.23090655
36CAMK2A1.20660932
37FES1.19955843
38PRKCG1.18576166
39KSR11.17692896
40MAPKAPK51.16954793
41MAPK131.15129509
42CAMK2B1.11410860
43SIK21.10608551
44PRPF4B1.07196109
45UHMK11.06881277
46NME11.05181831
47WNK41.04664875
48FGFR31.02357411
49TNK21.00118528
50STK380.99627121
51PINK10.96861783
52SGK4940.92684899
53SGK2230.92684899
54PTK2B0.90172032
55PRKD30.89947165
56WNK10.89458816
57CAMK2D0.88057378
58CSNK1G20.87883681
59JAK10.86592961
60PAK30.84989289
61AKT30.83044220
62PHKG10.78706481
63PHKG20.78706481
64CAMK10.77489880
65MAPK100.76731918
66RET0.76500003
67GRK70.75923471
68CDK140.75385178
69HIPK20.75087176
70PRKCE0.72468976
71CAMK2G0.72255660
72MAP3K10.72139396
73SGK20.71834749
74INSRR0.70681856
75PRKCH0.70155195
76MUSK0.69817424
77OBSCN0.69587813
78CDK180.68659855
79STK38L0.67624006
80CDK150.66474056
81STK110.66415020
82SGK10.65146913
83CAMK40.65037980
84RAF10.64033937
85FGR0.63416020
86ALK0.62671243
87CCNB10.62427164
88MAP3K60.58959794
89TYRO30.58749459
90PDPK10.57718672
91PDK10.57661475
92CDK11A0.56507595
93FER0.56429393
94LIMK10.55475841
95BCR0.54438938
96MAP2K10.54141162
97DYRK1A0.52082564
98ROCK10.49318553
99LMTK20.48768869
100CSNK1G30.47819795
101ROCK20.46924396
102WNK30.46519945
103MAP2K60.46386742
104PRKG10.45825989
105IRAK20.45788623
106PRKACA0.45508961
107MAP3K70.45423559
108PRKD10.44735672
109SGK30.43540617
110MARK20.42091243
111NEK90.41358796
112ADRBK20.41255844
113PKN10.40723437
114RPS6KA30.40375315
115ADRBK10.39710696
116BRAF0.39307483
117PRKG20.38566812
118PRKCZ0.38337411
119NEK60.37704633
120MAPK70.37299907
121JAK20.36878424
122RPS6KB10.36323261
123PRKCA0.36319059
124CAMK1G0.35973022
125MAPK120.35863786
126FYN0.35758925

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88665007
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22990821
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79539859
4GABAergic synapse_Homo sapiens_hsa047272.76172053
5Long-term potentiation_Homo sapiens_hsa047202.60728525
6Circadian entrainment_Homo sapiens_hsa047132.49903200
7Morphine addiction_Homo sapiens_hsa050322.46268798
8Glutamatergic synapse_Homo sapiens_hsa047242.44937839
9Amphetamine addiction_Homo sapiens_hsa050312.44905473
10Olfactory transduction_Homo sapiens_hsa047402.34650570
11Collecting duct acid secretion_Homo sapiens_hsa049662.23961824
12Salivary secretion_Homo sapiens_hsa049702.12139686
13Taste transduction_Homo sapiens_hsa047422.10013400
14Dopaminergic synapse_Homo sapiens_hsa047282.08260592
15Insulin secretion_Homo sapiens_hsa049111.94729884
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93370830
17Serotonergic synapse_Homo sapiens_hsa047261.88978225
18Long-term depression_Homo sapiens_hsa047301.85610089
19Renin secretion_Homo sapiens_hsa049241.85252204
20Oxidative phosphorylation_Homo sapiens_hsa001901.79333268
21Gastric acid secretion_Homo sapiens_hsa049711.78018350
22Cholinergic synapse_Homo sapiens_hsa047251.72111270
23Cocaine addiction_Homo sapiens_hsa050301.64713267
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59575502
25Vitamin B6 metabolism_Homo sapiens_hsa007501.57319510
26Calcium signaling pathway_Homo sapiens_hsa040201.53655551
27Oxytocin signaling pathway_Homo sapiens_hsa049211.50117933
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.45512306
29Alzheimers disease_Homo sapiens_hsa050101.45328410
30Vibrio cholerae infection_Homo sapiens_hsa051101.43052658
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37413384
32Cardiac muscle contraction_Homo sapiens_hsa042601.36891645
33Parkinsons disease_Homo sapiens_hsa050121.36854395
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34935712
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30371367
36GnRH signaling pathway_Homo sapiens_hsa049121.25682308
37Gap junction_Homo sapiens_hsa045401.23862363
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21617084
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21609490
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16645051
41cAMP signaling pathway_Homo sapiens_hsa040241.09888048
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08145284
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01225823
44Estrogen signaling pathway_Homo sapiens_hsa049151.01031491
45Pancreatic secretion_Homo sapiens_hsa049721.00604529
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99462796
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.97803053
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94095108
49Phototransduction_Homo sapiens_hsa047440.92464095
50Histidine metabolism_Homo sapiens_hsa003400.87129735
51Melanogenesis_Homo sapiens_hsa049160.84065038
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83784034
53Type II diabetes mellitus_Homo sapiens_hsa049300.80688351
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79986598
55Huntingtons disease_Homo sapiens_hsa050160.79735252
56Axon guidance_Homo sapiens_hsa043600.78783984
57mTOR signaling pathway_Homo sapiens_hsa041500.77184562
58Thyroid hormone synthesis_Homo sapiens_hsa049180.77123261
59Dorso-ventral axis formation_Homo sapiens_hsa043200.75255506
60Fatty acid biosynthesis_Homo sapiens_hsa000610.74657519
61Nitrogen metabolism_Homo sapiens_hsa009100.74082348
62ErbB signaling pathway_Homo sapiens_hsa040120.73888167
63Mineral absorption_Homo sapiens_hsa049780.72760102
64Glioma_Homo sapiens_hsa052140.72264241
65beta-Alanine metabolism_Homo sapiens_hsa004100.63443220
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.62476077
67Arginine biosynthesis_Homo sapiens_hsa002200.60974698
68Butanoate metabolism_Homo sapiens_hsa006500.59716112
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59545179
70Choline metabolism in cancer_Homo sapiens_hsa052310.58895270
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57887625
72Insulin signaling pathway_Homo sapiens_hsa049100.57029629
73Glucagon signaling pathway_Homo sapiens_hsa049220.57015484
74AMPK signaling pathway_Homo sapiens_hsa041520.55871523
75Rheumatoid arthritis_Homo sapiens_hsa053230.55378544
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55205528
77MAPK signaling pathway_Homo sapiens_hsa040100.54952440
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54391894
79Dilated cardiomyopathy_Homo sapiens_hsa054140.53769497
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51934870
81Type I diabetes mellitus_Homo sapiens_hsa049400.51545173
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50768100
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50722519
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49089061
85Bile secretion_Homo sapiens_hsa049760.48985553
86African trypanosomiasis_Homo sapiens_hsa051430.48835361
87Oocyte meiosis_Homo sapiens_hsa041140.48738548
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48156414
89Endocytosis_Homo sapiens_hsa041440.46661734
90Ras signaling pathway_Homo sapiens_hsa040140.46649406
91Arginine and proline metabolism_Homo sapiens_hsa003300.45821428
92Inositol phosphate metabolism_Homo sapiens_hsa005620.45007304
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43761025
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43376220
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.43312423
96PPAR signaling pathway_Homo sapiens_hsa033200.41249493
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39718542
98Prion diseases_Homo sapiens_hsa050200.39516397
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38980569
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38476134
101ABC transporters_Homo sapiens_hsa020100.38037241
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37157168
103VEGF signaling pathway_Homo sapiens_hsa043700.36103293
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35246504
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.34486941
106Regulation of autophagy_Homo sapiens_hsa041400.34178410
107Alcoholism_Homo sapiens_hsa050340.34092475
108Renal cell carcinoma_Homo sapiens_hsa052110.33662702
109Sphingolipid metabolism_Homo sapiens_hsa006000.32622436
110Circadian rhythm_Homo sapiens_hsa047100.32118246
111Tight junction_Homo sapiens_hsa045300.31905706
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31506314
113Ovarian steroidogenesis_Homo sapiens_hsa049130.31393828
114Rap1 signaling pathway_Homo sapiens_hsa040150.31304351
115Insulin resistance_Homo sapiens_hsa049310.30697913
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30156892
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.29874384
118Sulfur metabolism_Homo sapiens_hsa009200.28292098
119Endometrial cancer_Homo sapiens_hsa052130.28240503
120Ether lipid metabolism_Homo sapiens_hsa005650.23793779
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.23265306
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21760760
123Wnt signaling pathway_Homo sapiens_hsa043100.19595663
124Pyruvate metabolism_Homo sapiens_hsa006200.18638909

Most similar genes based on co-expression Upload to Enrichr

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