IGKV1-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* complement activation, classical pathway (GO:0006958)9.77363018
2positive regulation of respiratory burst (GO:0060267)8.42459000
3* complement activation (GO:0006956)7.77268212
4glomerular filtration (GO:0003094)7.32942364
5renal filtration (GO:0097205)6.62153893
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.09792744
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.08668799
8antibacterial humoral response (GO:0019731)5.92740293
9antimicrobial humoral response (GO:0019730)5.86811575
10antigen processing and presentation of endogenous antigen (GO:0019883)5.76743164
11* protein activation cascade (GO:0072376)5.71521301
12regulation of respiratory burst (GO:0060263)5.57409368
13* humoral immune response (GO:0006959)4.86059491
14* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.71320544
15* Fc-gamma receptor signaling pathway (GO:0038094)4.71320544
16* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.71320544
17* Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.68784626
18regulation of cellular extravasation (GO:0002691)4.51421322
19detection of bacterium (GO:0016045)4.43424486
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32917765
21detection of other organism (GO:0098543)4.31968947
22retina homeostasis (GO:0001895)4.13894977
23immunoglobulin mediated immune response (GO:0016064)4.05528268
24regulation of dendritic cell antigen processing and presentation (GO:0002604)4.01956192
25interferon-gamma-mediated signaling pathway (GO:0060333)3.88931461
26negative regulation of cell killing (GO:0031342)3.72984208
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72984208
28type I interferon signaling pathway (GO:0060337)3.56411709
29cellular response to type I interferon (GO:0071357)3.56411709
30response to type I interferon (GO:0034340)3.54607620
31regulation of antigen processing and presentation (GO:0002577)3.52649962
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.43682270
33germinal center formation (GO:0002467)3.42129393
34positive regulation of antigen processing and presentation (GO:0002579)3.40984640
35angiotensin maturation (GO:0002003)3.39525474
36chronic inflammatory response (GO:0002544)3.23437759
37detection of external biotic stimulus (GO:0098581)3.16904545
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.15227542
39cellular response to interferon-gamma (GO:0071346)3.15028330
40* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.14001466
41positive regulation of gamma-delta T cell activation (GO:0046645)3.12547240
42positive regulation of pseudopodium assembly (GO:0031274)3.05860898
43B cell mediated immunity (GO:0019724)3.05191485
44surfactant homeostasis (GO:0043129)3.03207283
45response to interferon-gamma (GO:0034341)2.95968595
46production of molecular mediator of immune response (GO:0002440)2.93584489
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92817155
48regulation of integrin activation (GO:0033623)2.85855864
49regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.84526957
50T-helper 1 type immune response (GO:0042088)2.82141627
51negative regulation of myotube differentiation (GO:0010832)2.81303433
52myeloid dendritic cell differentiation (GO:0043011)2.75691031
53dendritic cell chemotaxis (GO:0002407)2.73890244
54peptide catabolic process (GO:0043171)2.71956312
55regulation of pseudopodium assembly (GO:0031272)2.71910664
56regulation of T cell tolerance induction (GO:0002664)2.67409931
57detection of biotic stimulus (GO:0009595)2.66435743
58eosinophil chemotaxis (GO:0048245)2.65602144
59maintenance of gastrointestinal epithelium (GO:0030277)2.61505580
60NIK/NF-kappaB signaling (GO:0038061)2.59791836
61adhesion of symbiont to host cell (GO:0044650)2.57568324
62virion attachment to host cell (GO:0019062)2.57568324
63protein-chromophore linkage (GO:0018298)2.56773027
64eosinophil migration (GO:0072677)2.54692966
65T cell costimulation (GO:0031295)2.53240287
66myeloid dendritic cell activation (GO:0001773)2.52413023
67positive regulation of T cell migration (GO:2000406)2.50183958
68lymphocyte costimulation (GO:0031294)2.49475056
69* immune response-activating signal transduction (GO:0002757)2.49310628
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48827200
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.48827200
72modulation by symbiont of host immune response (GO:0052553)2.48827200
73positive regulation by symbiont of host defense response (GO:0052509)2.48827200
74modulation by symbiont of host defense response (GO:0052031)2.48827200
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48827200
76* activation of immune response (GO:0002253)2.47713117
77respiratory burst (GO:0045730)2.47172312
78intestinal absorption (GO:0050892)2.46781663
79regulation of tolerance induction (GO:0002643)2.45106415
80positive regulation of granulocyte chemotaxis (GO:0071624)2.44359688
81regulation of T cell migration (GO:2000404)2.43335375
82regulation of B cell receptor signaling pathway (GO:0050855)2.41315139
83regulation of necrotic cell death (GO:0010939)2.40259759
84negative regulation of complement activation (GO:0045916)2.39988914
85negative regulation of humoral immune response (GO:0002921)2.38655884
86regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38476107
87dendritic cell migration (GO:0036336)2.38111210
88B cell receptor signaling pathway (GO:0050853)2.37614283
89antigen processing and presentation via MHC class Ib (GO:0002475)2.36575324
90defense response to Gram-negative bacterium (GO:0050829)2.36563503
91regulation of regulatory T cell differentiation (GO:0045589)2.35980045
92interferon-gamma secretion (GO:0072643)2.32980920
93regulation of gamma-delta T cell activation (GO:0046643)2.32502003
94positive regulation of lymphocyte migration (GO:2000403)2.29606386
95innate immune response in mucosa (GO:0002227)2.28721448
96regulation of vitamin metabolic process (GO:0030656)2.27715684
97adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.27382983
98response to bacterium (GO:0009617)2.27250476
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.25945447
100response to interferon-beta (GO:0035456)2.25864249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.78008961
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.01945790
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.91514348
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.97332997
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.25490982
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98538351
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.91019799
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60458066
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.35499805
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30638750
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24627845
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.20070438
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05860346
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01360042
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.99380423
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96030385
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90498310
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.87517126
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86768531
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85750817
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82537300
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82501228
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82158464
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75168762
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.73917749
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72815201
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68055612
28VDR_24763502_ChIP-Seq_THP-1_Human1.63970158
29RUNX_20019798_ChIP-Seq_JUKART_Human1.59733431
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59352070
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56884938
32CLOCK_20551151_ChIP-Seq_293T_Human1.55715589
33SOX2_20726797_ChIP-Seq_SW620_Human1.54653075
34LXR_22292898_ChIP-Seq_THP-1_Human1.53966605
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44332585
36VDR_21846776_ChIP-Seq_THP-1_Human1.44141604
37MYB_26560356_Chip-Seq_TH2_Human1.43003977
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39401142
39GATA1_22025678_ChIP-Seq_K562_Human1.39089915
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38787179
41GATA1_19941826_ChIP-Seq_K562_Human1.35204304
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35095830
43MAF_26560356_Chip-Seq_TH1_Human1.34972768
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34566557
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.34253407
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33464102
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29888333
48GATA4_25053715_ChIP-Seq_YYC3_Human1.29819075
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.29277278
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25623746
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.24137717
52SPI1_23127762_ChIP-Seq_K562_Human1.23959440
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23745039
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.20531981
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20302201
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19897066
57MYB_26560356_Chip-Seq_TH1_Human1.19849194
58EGR1_19032775_ChIP-ChIP_M12_Human1.18658327
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18052295
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17975986
61TCF7_22412390_ChIP-Seq_EML_Mouse1.17784165
62SPI1_23547873_ChIP-Seq_NB4_Human1.16983310
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.16930174
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16509847
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15885255
66GATA6_25053715_ChIP-Seq_YYC3_Human1.15249717
67VDR_24787735_ChIP-Seq_THP-1_Human1.14092620
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13603011
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.12745083
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12707077
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12406197
72MYC_22102868_ChIP-Seq_BL_Human1.11519027
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.10927256
74UTX_26944678_Chip-Seq_JUKART_Human1.10840579
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08568531
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07220222
77GATA2_19941826_ChIP-Seq_K562_Human1.07105384
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.05845891
79SCL_19346495_ChIP-Seq_HPC-7_Human1.04636186
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02589390
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02243969
82RACK7_27058665_Chip-Seq_MCF-7_Human1.01521924
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01261726
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00530927
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.99927240
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99687657
87PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99655197
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.98787736
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95612010
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94674759
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94357448
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92519566
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91117016
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90799974
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88894419
96GATA3_27048872_Chip-Seq_THYMUS_Human0.88143162
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87687158
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86944413
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85679661
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84741777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.36091669
2MP0003303_peritoneal_inflammation3.58688894
3MP0010234_abnormal_vibrissa_follicle3.22486594
4MP0001835_abnormal_antigen_presentation3.12225002
5MP0003436_decreased_susceptibility_to3.05481438
6MP0010155_abnormal_intestine_physiology2.91926356
7MP0005387_immune_system_phenotype2.87977755
8MP0001790_abnormal_immune_system2.87977755
9MP0000685_abnormal_immune_system2.55567868
10MP0001800_abnormal_humoral_immune2.52186667
11MP0005025_abnormal_response_to2.48878156
12MP0009785_altered_susceptibility_to2.36900975
13MP0003300_gastrointestinal_ulcer2.35124692
14MP0005671_abnormal_response_to2.30221435
15MP0005275_abnormal_skin_tensile2.25970696
16MP0005000_abnormal_immune_tolerance2.18375317
17MP0004264_abnormal_extraembryonic_tissu2.16970766
18MP0000465_gastrointestinal_hemorrhage2.16923156
19MP0005166_decreased_susceptibility_to2.05046971
20MP0004782_abnormal_surfactant_physiolog2.02148769
21MP0003866_abnormal_defecation2.01270023
22MP0010352_gastrointestinal_tract_polyps2.00445516
23MP0002452_abnormal_antigen_presenting1.97546941
24MP0001533_abnormal_skeleton_physiology1.96218234
25MP0002148_abnormal_hypersensitivity_rea1.96046725
26MP0002419_abnormal_innate_immunity1.89750257
27MP0002166_altered_tumor_susceptibility1.89105254
28MP0002138_abnormal_hepatobiliary_system1.86122195
29MP0001873_stomach_inflammation1.85272808
30MP0002723_abnormal_immune_serum1.85198416
31MP0001819_abnormal_immune_cell1.77936250
32MP0004947_skin_inflammation1.77326721
33MP0002420_abnormal_adaptive_immunity1.76887632
34MP0001845_abnormal_inflammatory_respons1.68274283
35MP0003183_abnormal_peptide_metabolism1.65225046
36MP0006082_CNS_inflammation1.60648267
37MP0002796_impaired_skin_barrier1.57554100
38MP0003191_abnormal_cellular_cholesterol1.55047329
39MP0004858_abnormal_nervous_system1.54834344
40MP0001663_abnormal_digestive_system1.47622991
41MP0002139_abnormal_hepatobiliary_system1.45465042
42MP0003763_abnormal_thymus_physiology1.42179817
43MP0008438_abnormal_cutaneous_collagen1.40509215
44MP0008004_abnormal_stomach_pH1.38186279
45MP0009333_abnormal_splenocyte_physiolog1.37899465
46MP0002006_tumorigenesis1.37559187
47MP0003448_altered_tumor_morphology1.33550466
48MP0005310_abnormal_salivary_gland1.30967893
49MP0003075_altered_response_to1.29145893
50MP0005360_urolithiasis1.28470855
51MP0000716_abnormal_immune_system1.28354044
52MP0005023_abnormal_wound_healing1.28273889
53MP0005464_abnormal_platelet_physiology1.22717327
54MP0000343_altered_response_to1.21905684
55MP0003045_fibrosis1.21818483
56MP0005503_abnormal_tendon_morphology1.19168166
57MP0002398_abnormal_bone_marrow1.19045685
58MP0001666_abnormal_nutrient_absorption1.18540702
59MP0002998_abnormal_bone_remodeling1.14810662
60MP0000604_amyloidosis1.13976989
61MP0000858_altered_metastatic_potential1.13704539
62MP0000490_abnormal_crypts_of1.12069647
63MP0009840_abnormal_foam_cell1.11991723
64MP0002405_respiratory_system_inflammati1.10796435
65MP0002933_joint_inflammation1.09906538
66MP0000477_abnormal_intestine_morphology1.09845386
67MP0005381_digestive/alimentary_phenotyp1.08908471
68MP0008469_abnormal_protein_level1.08728678
69MP0005085_abnormal_gallbladder_physiolo1.07460447
70MP0001851_eye_inflammation1.06141491
71MP0003453_abnormal_keratinocyte_physiol1.04985370
72MP0009764_decreased_sensitivity_to1.02602949
73MP0003279_aneurysm1.02400389
74MP0002429_abnormal_blood_cell1.01329052
75MP0003329_amyloid_beta_deposits0.99590953
76MP0005409_darkened_coat_color0.98600031
77MP0001664_abnormal_digestion0.98129575
78MP0005390_skeleton_phenotype0.98091541
79MP0005164_abnormal_response_to0.96068177
80MP0000249_abnormal_blood_vessel0.94329280
81MP0002722_abnormal_immune_system0.90194652
82MP0003828_pulmonary_edema0.89933322
83MP0000689_abnormal_spleen_morphology0.86810965
84MP0002876_abnormal_thyroid_physiology0.86722263
85MP0003868_abnormal_feces_composition0.86338782
86MP0002277_abnormal_respiratory_mucosa0.85264990
87MP0004147_increased_porphyrin_level0.84926904
88MP0003566_abnormal_cell_adhesion0.84788672
89MP0001216_abnormal_epidermal_layer0.82783265
90MP0005165_increased_susceptibility_to0.81441575
91MP0002133_abnormal_respiratory_system0.79702935
92MP0005388_respiratory_system_phenotype0.79702935
93MP0009643_abnormal_urine_homeostasis0.79554970
94MP0001958_emphysema0.78194950
95MP0003091_abnormal_cell_migration0.77391033
96MP0009278_abnormal_bone_marrow0.76519786
97MP0005058_abnormal_lysosome_morphology0.75996224
98MP0002136_abnormal_kidney_physiology0.75574093
99MP0003795_abnormal_bone_structure0.74832960
100MP0005451_abnormal_body_composition0.74649863

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.07483946
2Prostate neoplasm (HP:0100787)5.60622065
3Abnormality of macrophages (HP:0004311)4.98319898
4Eczematoid dermatitis (HP:0000976)4.81736909
5Malnutrition (HP:0004395)4.10670176
6Abnormality of the prostate (HP:0008775)4.01553338
7Vasculitis (HP:0002633)3.97449247
8Abnormality of complement system (HP:0005339)3.94383542
9Glomerulonephritis (HP:0000099)3.77059191
10Increased IgE level (HP:0003212)3.71664839
11Complement deficiency (HP:0004431)3.67160765
12Gastrointestinal stroma tumor (HP:0100723)3.60238548
13Recurrent bronchitis (HP:0002837)3.55493850
14Recurrent bacterial skin infections (HP:0005406)3.26870799
15Agammaglobulinemia (HP:0004432)3.23236926
16Abnormality of cells of the lymphoid lineage (HP:0012140)3.19893766
17Spontaneous hematomas (HP:0007420)3.17987954
18Nephritis (HP:0000123)3.15639327
19Premature loss of primary teeth (HP:0006323)3.12890497
20Urticaria (HP:0001025)3.12136558
21Skin rash (HP:0000988)3.03367475
22Colitis (HP:0002583)3.03043687
23Recurrent abscess formation (HP:0002722)3.01941254
24Meningitis (HP:0001287)2.99772075
25Chronic diarrhea (HP:0002028)2.95950742
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.92873330
27Cellulitis (HP:0100658)2.92560668
28Hyperactive renin-angiotensin system (HP:0000841)2.89619567
29Gastrointestinal infarctions (HP:0005244)2.87801236
30Leukocytosis (HP:0001974)2.87143365
31Gingivitis (HP:0000230)2.81936898
32Osteomyelitis (HP:0002754)2.75962472
33Inflammation of the large intestine (HP:0002037)2.74742237
34Abnormality of the nasal mucosa (HP:0000433)2.73786166
35Emphysema (HP:0002097)2.72039297
36Myositis (HP:0100614)2.63691483
37Alopecia of scalp (HP:0002293)2.62340823
38Gastrointestinal inflammation (HP:0004386)2.60387386
39Orchitis (HP:0100796)2.59864628
40Chronic otitis media (HP:0000389)2.58194142
41Recurrent gram-negative bacterial infections (HP:0005420)2.55928115
42Hemoptysis (HP:0002105)2.55050565
43Right ventricular cardiomyopathy (HP:0011663)2.53374185
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52058048
45Abnormality of small intestinal villus morphology (HP:0011472)2.50717007
46Villous atrophy (HP:0011473)2.50717007
47Mediastinal lymphadenopathy (HP:0100721)2.46148173
48Chronic obstructive pulmonary disease (HP:0006510)2.42915259
49Obstructive lung disease (HP:0006536)2.42915259
50Pulmonary infiltrates (HP:0002113)2.42248639
51Recurrent viral infections (HP:0004429)2.39988692
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37763377
53Interstitial pulmonary disease (HP:0006530)2.36528194
54Hypergammaglobulinemia (HP:0010702)2.36326748
55Recurrent sinusitis (HP:0011108)2.36222276
56Abnormality of male internal genitalia (HP:0000022)2.33780585
57Recurrent skin infections (HP:0001581)2.33756085
58Pustule (HP:0200039)2.29997634
59Abnormality of B cell number (HP:0010975)2.29646405
60Elevated erythrocyte sedimentation rate (HP:0003565)2.29327747
61Recurrent fungal infections (HP:0002841)2.26735612
62Bronchitis (HP:0012387)2.22269309
63Ileus (HP:0002595)2.18706182
64Neoplasm of the lung (HP:0100526)2.17020104
65Restrictive lung disease (HP:0002091)2.14510515
66Polycythemia (HP:0001901)2.14081301
67Decreased circulating renin level (HP:0003351)2.14075666
68Skin ulcer (HP:0200042)2.13878558
69Optic neuritis (HP:0100653)2.13128462
70Retrobulbar optic neuritis (HP:0100654)2.13128462
71Nasal polyposis (HP:0100582)2.11565027
72Purpura (HP:0000979)2.11129732
73Chronic mucocutaneous candidiasis (HP:0002728)2.07635696
74Recurrent cutaneous fungal infections (HP:0011370)2.07635696
75Autoimmune hemolytic anemia (HP:0001890)2.05958057
76Recurrent pneumonia (HP:0006532)2.05360044
77Hypermelanotic macule (HP:0001034)2.04747164
78Xerostomia (HP:0000217)2.04485869
79Keratoconjunctivitis sicca (HP:0001097)2.03391604
80Autoimmune thrombocytopenia (HP:0001973)2.02094302
81Recurrent lower respiratory tract infections (HP:0002783)1.99336391
82Hemorrhage of the eye (HP:0011885)1.97447940
83Chest pain (HP:0100749)1.97185592
84Abnormality of nail color (HP:0100643)1.96305741
85Abnormality of T cell physiology (HP:0011840)1.95222316
86Lymphopenia (HP:0001888)1.93752613
87Periodontitis (HP:0000704)1.93615003
88Increased IgM level (HP:0003496)1.92922380
89Erythema (HP:0010783)1.90947519
90IgA deficiency (HP:0002720)1.90039989
91Abnormality of the pleura (HP:0002103)1.88227214
92Palmoplantar hyperkeratosis (HP:0000972)1.88080274
93Fragile skin (HP:0001030)1.84830061
94IgM deficiency (HP:0002850)1.84407762
95Plantar hyperkeratosis (HP:0007556)1.83616271
96Osteolytic defects of the hand bones (HP:0009699)1.83472142
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.83472142
98Sepsis (HP:0100806)1.83230835
99Abnormality of T cell number (HP:0011839)1.82857502
100Thick nail (HP:0001805)1.82390180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.69382690
2TYK23.46979154
3FGFR43.23735741
4MST1R3.09492833
5MAP4K13.07032499
6RIPK42.95259080
7PRPF4B2.69113822
8EPHA32.54511761
9BLK2.53480415
10RIPK12.53082495
11JAK12.22764118
12EPHB12.22219734
13KIT2.06143694
14JAK31.95906746
15FGFR31.93798496
16IKBKE1.84422830
17MAP3K141.83842798
18CDC42BPA1.83632192
19PIK3CA1.66568778
20ZAP701.61906883
21CSK1.59137801
22IRAK41.58304428
23GRK61.52765674
24TBK11.46808640
25ACVR1B1.45675040
26FES1.43622909
27JAK21.38989591
28MAP3K11.32878853
29SYK1.27499489
30TXK1.26831097
31LYN1.21888853
32PDGFRA1.21019687
33EPHA21.19068433
34STK241.16211002
35FER1.12169481
36SMG11.09019718
37MATK1.06887028
38MAP3K101.06139334
39IRAK11.05613179
40TGFBR21.05460387
41DDR21.04486315
42BTK1.03237803
43MET1.01007559
44NLK0.99974965
45PRKG20.97116790
46TAOK10.96140440
47MAP3K30.95336165
48CSF1R0.95038414
49PTK60.95019168
50MAP3K130.94438950
51BMPR20.91224283
52HCK0.88318719
53PKN20.86737324
54YES10.85675355
55TRIB30.84551553
56EPHB20.82328901
57SIK30.78420694
58MAP2K30.77572765
59RET0.76442752
60FGR0.75119862
61LCK0.73727820
62MAP3K60.70655864
63MAPK70.68553399
64HIPK20.66740463
65IKBKB0.66428926
66PDPK10.62866768
67MYLK0.60271161
68FYN0.59909895
69TGFBR10.57267759
70PDGFRB0.57111088
71LRRK20.56242001
72DMPK0.54646184
73LMTK20.53739534
74OXSR10.53198213
75MAP3K20.52179364
76CDK60.51583940
77PDK10.50149009
78MAPKAPK20.48346091
79MAP3K110.48270652
80KSR20.47882674
81MAPK110.47801968
82NEK90.47799393
83ITK0.47012482
84TESK20.46411314
85STK390.44511132
86PAK40.44037573
87GRK50.41650441
88TEC0.40437368
89TAOK30.40123568
90PRKCQ0.38245800
91MAP2K20.37918321
92TNK20.37805082
93PRKCD0.37294859
94TAOK20.35439356
95BMX0.32688545
96SRC0.31226190
97IGF1R0.31137280
98IRAK30.30967252
99ABL10.29504641
100MAPK40.27578589

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.83011081
2Staphylococcus aureus infection_Homo sapiens_hsa051503.79306240
3Allograft rejection_Homo sapiens_hsa053303.35433329
4Autoimmune thyroid disease_Homo sapiens_hsa053203.22539902
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.11691238
6Graft-versus-host disease_Homo sapiens_hsa053323.10298761
7Leishmaniasis_Homo sapiens_hsa051402.60918792
8Type I diabetes mellitus_Homo sapiens_hsa049402.55714965
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26454686
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24326400
11Antigen processing and presentation_Homo sapiens_hsa046122.20693096
12Viral myocarditis_Homo sapiens_hsa054162.01280418
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.95771601
14Primary immunodeficiency_Homo sapiens_hsa053401.66531052
15Toxoplasmosis_Homo sapiens_hsa051451.62334032
16Pertussis_Homo sapiens_hsa051331.57597166
17Influenza A_Homo sapiens_hsa051641.44313237
18Hematopoietic cell lineage_Homo sapiens_hsa046401.44045602
19Tuberculosis_Homo sapiens_hsa051521.43965012
20Osteoclast differentiation_Homo sapiens_hsa043801.43343469
21Rheumatoid arthritis_Homo sapiens_hsa053231.40266439
22Systemic lupus erythematosus_Homo sapiens_hsa053221.36158658
23Renin-angiotensin system_Homo sapiens_hsa046141.35450952
24Arginine biosynthesis_Homo sapiens_hsa002201.29071162
25B cell receptor signaling pathway_Homo sapiens_hsa046621.29011258
26Malaria_Homo sapiens_hsa051441.25446656
27Sulfur metabolism_Homo sapiens_hsa009201.17207876
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.17168592
29Fat digestion and absorption_Homo sapiens_hsa049751.16734785
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15451145
31Complement and coagulation cascades_Homo sapiens_hsa046101.14037077
32Herpes simplex infection_Homo sapiens_hsa051681.12657758
33Phagosome_Homo sapiens_hsa041451.12170762
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10935637
35Chemokine signaling pathway_Homo sapiens_hsa040621.06235297
36Fructose and mannose metabolism_Homo sapiens_hsa000511.04115267
37Other glycan degradation_Homo sapiens_hsa005111.03547573
38TNF signaling pathway_Homo sapiens_hsa046681.01578274
39African trypanosomiasis_Homo sapiens_hsa051430.99757932
40Hepatitis C_Homo sapiens_hsa051600.97967714
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.97362069
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91778775
43Protein digestion and absorption_Homo sapiens_hsa049740.91301971
44Measles_Homo sapiens_hsa051620.90793933
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88627307
46Mineral absorption_Homo sapiens_hsa049780.86554186
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85998267
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85601638
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84448366
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76785203
51Amoebiasis_Homo sapiens_hsa051460.73904180
52Arachidonic acid metabolism_Homo sapiens_hsa005900.73794714
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73354779
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.72712315
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71999924
56Histidine metabolism_Homo sapiens_hsa003400.69295146
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68690659
58Caffeine metabolism_Homo sapiens_hsa002320.66250318
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65923643
60Pancreatic secretion_Homo sapiens_hsa049720.62846150
61Acute myeloid leukemia_Homo sapiens_hsa052210.60341853
62Starch and sucrose metabolism_Homo sapiens_hsa005000.59593421
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58248345
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56934976
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54117210
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.53651902
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52977114
68Linoleic acid metabolism_Homo sapiens_hsa005910.52623312
69Apoptosis_Homo sapiens_hsa042100.52618142
70Salmonella infection_Homo sapiens_hsa051320.51676796
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51221299
72Galactose metabolism_Homo sapiens_hsa000520.50123414
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47967284
74PPAR signaling pathway_Homo sapiens_hsa033200.46726270
75Lysosome_Homo sapiens_hsa041420.44692516
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43927780
77Platelet activation_Homo sapiens_hsa046110.43438285
78Hepatitis B_Homo sapiens_hsa051610.43319474
79Pancreatic cancer_Homo sapiens_hsa052120.43109442
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42851364
81Nitrogen metabolism_Homo sapiens_hsa009100.42684755
82Prolactin signaling pathway_Homo sapiens_hsa049170.40812592
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39933154
84Ether lipid metabolism_Homo sapiens_hsa005650.39635003
85Vitamin digestion and absorption_Homo sapiens_hsa049770.39110257
86Legionellosis_Homo sapiens_hsa051340.37952983
87Thyroid hormone synthesis_Homo sapiens_hsa049180.37201180
88T cell receptor signaling pathway_Homo sapiens_hsa046600.37053174
89HTLV-I infection_Homo sapiens_hsa051660.36840314
90Retinol metabolism_Homo sapiens_hsa008300.36598046
91Prion diseases_Homo sapiens_hsa050200.35983558
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35524175
93HIF-1 signaling pathway_Homo sapiens_hsa040660.34857104
94Viral carcinogenesis_Homo sapiens_hsa052030.32128576
95Epstein-Barr virus infection_Homo sapiens_hsa051690.31755379
96Arginine and proline metabolism_Homo sapiens_hsa003300.30730364
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.30581375
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29607803
99GnRH signaling pathway_Homo sapiens_hsa049120.29107109
100Fatty acid degradation_Homo sapiens_hsa000710.27569754

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