IGKV3-20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)8.66768512
2positive regulation of respiratory burst (GO:0060267)8.61353358
3glomerular filtration (GO:0003094)7.47973225
4renal filtration (GO:0097205)6.76434247
5protein activation cascade (GO:0072376)6.38035090
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99987591
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.96473274
8regulation of respiratory burst (GO:0060263)5.67215368
9antigen processing and presentation of endogenous antigen (GO:0019883)5.62713720
10antibacterial humoral response (GO:0019731)5.59671179
11antimicrobial humoral response (GO:0019730)5.50953644
12Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.31841599
13immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.31841599
14Fc-gamma receptor signaling pathway (GO:0038094)5.31841599
15Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.28241482
16humoral immune response (GO:0006959)5.16197814
17regulation of cellular extravasation (GO:0002691)4.62978263
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20550060
19retina homeostasis (GO:0001895)3.89979594
20angiotensin maturation (GO:0002003)3.87808872
21regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81649253
22immunoglobulin mediated immune response (GO:0016064)3.68444628
23detection of bacterium (GO:0016045)3.65285323
24interferon-gamma-mediated signaling pathway (GO:0060333)3.62633625
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.58387707
26detection of other organism (GO:0098543)3.56998644
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49372789
28negative regulation of cell killing (GO:0031342)3.49372789
29regulation of antigen processing and presentation (GO:0002577)3.46004096
30immune response-activating cell surface receptor signaling pathway (GO:0002429)3.39024412
31germinal center formation (GO:0002467)3.35656316
32type I interferon signaling pathway (GO:0060337)3.30626253
33cellular response to type I interferon (GO:0071357)3.30626253
34positive regulation of pseudopodium assembly (GO:0031274)3.29933169
35response to type I interferon (GO:0034340)3.28901876
36surfactant homeostasis (GO:0043129)3.25597195
37regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.23727265
38positive regulation of antigen processing and presentation (GO:0002579)3.21178757
39negative regulation of myotube differentiation (GO:0010832)3.20029312
40positive regulation of Cdc42 GTPase activity (GO:0043089)3.13805151
41intestinal absorption (GO:0050892)3.11720323
42chronic inflammatory response (GO:0002544)2.98969230
43positive regulation of gamma-delta T cell activation (GO:0046645)2.98212762
44cellular response to interferon-gamma (GO:0071346)2.95250066
45maintenance of gastrointestinal epithelium (GO:0030277)2.93503476
46regulation of pseudopodium assembly (GO:0031272)2.92540902
47peptide catabolic process (GO:0043171)2.91557277
48dendritic cell chemotaxis (GO:0002407)2.90938238
49response to interferon-gamma (GO:0034341)2.77506381
50B cell mediated immunity (GO:0019724)2.77005349
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73166293
52adhesion of symbiont to host cell (GO:0044650)2.70876458
53virion attachment to host cell (GO:0019062)2.70876458
54production of molecular mediator of immune response (GO:0002440)2.68923193
55eosinophil chemotaxis (GO:0048245)2.67541110
56protein-chromophore linkage (GO:0018298)2.65817183
57detection of external biotic stimulus (GO:0098581)2.64711396
58oligosaccharide biosynthetic process (GO:0009312)2.64520703
59immune response-activating signal transduction (GO:0002757)2.62875847
60NIK/NF-kappaB signaling (GO:0038061)2.62689818
61negative regulation of bone resorption (GO:0045779)2.62662714
62regulation of integrin activation (GO:0033623)2.61632128
63gonadal mesoderm development (GO:0007506)2.61405269
64activation of immune response (GO:0002253)2.60467589
65regulation of vitamin metabolic process (GO:0030656)2.59329161
66regulation of guanylate cyclase activity (GO:0031282)2.53871811
67T-helper 1 type immune response (GO:0042088)2.53153711
68regulation of T cell tolerance induction (GO:0002664)2.52658199
69B cell receptor signaling pathway (GO:0050853)2.51217936
70myeloid dendritic cell differentiation (GO:0043011)2.50925593
71regulation of glucose import in response to insulin stimulus (GO:2001273)2.50835943
72dendritic cell migration (GO:0036336)2.49295967
73COPI coating of Golgi vesicle (GO:0048205)2.49145442
74Golgi transport vesicle coating (GO:0048200)2.49145442
75negative regulation of complement activation (GO:0045916)2.45379041
76T cell costimulation (GO:0031295)2.45300394
77eosinophil migration (GO:0072677)2.44093579
78antigen processing and presentation via MHC class Ib (GO:0002475)2.43562144
79interferon-gamma secretion (GO:0072643)2.42649036
80lymphocyte costimulation (GO:0031294)2.41423361
81regulation of necrotic cell death (GO:0010939)2.41095478
82cellular glucuronidation (GO:0052695)2.38821193
83regulation of regulatory T cell differentiation (GO:0045589)2.35366466
84glucuronate metabolic process (GO:0019585)2.34225579
85uronic acid metabolic process (GO:0006063)2.34225579
86bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34118167
87negative regulation of humoral immune response (GO:0002921)2.33577680
88regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32760525
89O-glycan processing (GO:0016266)2.31887943
90myeloid dendritic cell activation (GO:0001773)2.31808889
91regulation of B cell receptor signaling pathway (GO:0050855)2.30015858
92epithelial structure maintenance (GO:0010669)2.27881021
93defense response to Gram-negative bacterium (GO:0050829)2.26206485
94positive regulation of T cell migration (GO:2000406)2.24739441
95regulation of gamma-delta T cell activation (GO:0046643)2.24049320
96regulation of tolerance induction (GO:0002643)2.23679688
97positive regulation of granulocyte chemotaxis (GO:0071624)2.21901025
98regulation of macrophage chemotaxis (GO:0010758)2.21147685
99glycosphingolipid catabolic process (GO:0046479)2.20855305
100complement activation, classical pathway (GO:0006958)10.9600113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.00790205
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.87891820
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.87698362
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.89798600
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.22783779
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73437514
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.71989630
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.63519557
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58944907
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34666749
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.33531333
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.24292070
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22499504
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.11581583
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05382399
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04836896
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97662274
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91676420
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90342680
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.86108536
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85968259
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.83067947
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81794117
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79100977
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74363018
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72167274
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71636538
28CLOCK_20551151_ChIP-Seq_293T_Human1.71028453
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68682909
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67065713
31RUNX_20019798_ChIP-Seq_JUKART_Human1.62750063
32SOX2_20726797_ChIP-Seq_SW620_Human1.62192072
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.57827647
34VDR_24763502_ChIP-Seq_THP-1_Human1.51531491
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48962445
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48552654
37GATA4_25053715_ChIP-Seq_YYC3_Human1.47591238
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47538458
39MYC_22102868_ChIP-Seq_BL_Human1.46318206
40MYB_26560356_Chip-Seq_TH2_Human1.46145788
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37839701
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.37455321
43LXR_22292898_ChIP-Seq_THP-1_Human1.37207011
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35019935
45GATA6_25053715_ChIP-Seq_YYC3_Human1.33750143
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.31866003
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31082523
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30124679
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.29881829
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29739040
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29642673
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28841746
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28632951
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28391843
55VDR_21846776_ChIP-Seq_THP-1_Human1.28226408
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25113418
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23513231
58MYB_26560356_Chip-Seq_TH1_Human1.23003369
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.20197132
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.19460321
61SPI1_23127762_ChIP-Seq_K562_Human1.19381456
62MAF_26560356_Chip-Seq_TH1_Human1.18859242
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17393269
64EGR1_19032775_ChIP-ChIP_M12_Human1.16864127
65SPI1_23547873_ChIP-Seq_NB4_Human1.16724121
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15422317
67GATA1_22025678_ChIP-Seq_K562_Human1.15216077
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13959273
69TCF7_22412390_ChIP-Seq_EML_Mouse1.13093943
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.11519077
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11474384
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10816505
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10354257
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08017761
75VDR_24787735_ChIP-Seq_THP-1_Human1.07735381
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07657032
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07545457
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06489530
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.06191442
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05154972
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.04950205
82GATA1_19941826_ChIP-Seq_K562_Human1.04421237
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.04359945
84RACK7_27058665_Chip-Seq_MCF-7_Human1.03979172
85UTX_26944678_Chip-Seq_JUKART_Human1.02846844
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98506381
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98290321
88SCL_19346495_ChIP-Seq_HPC-7_Human0.94727556
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94203581
90GATA2_19941826_ChIP-Seq_K562_Human0.94189861
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91182966
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90332782
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89353733
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.89090370
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86701300
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.86654144
97GATA3_27048872_Chip-Seq_THYMUS_Human0.86061177
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84268463
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83477999
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80154339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.92163984
2MP0003303_peritoneal_inflammation3.58691250
3MP0010234_abnormal_vibrissa_follicle3.40815305
4MP0001835_abnormal_antigen_presentation3.05364486
5MP0010155_abnormal_intestine_physiology3.04989976
6MP0003436_decreased_susceptibility_to2.84973345
7MP0001790_abnormal_immune_system2.81063178
8MP0005387_immune_system_phenotype2.81063178
9MP0001800_abnormal_humoral_immune2.45250910
10MP0004264_abnormal_extraembryonic_tissu2.43002243
11MP0010352_gastrointestinal_tract_polyps2.37924836
12MP0000685_abnormal_immune_system2.35150311
13MP0003300_gastrointestinal_ulcer2.29068243
14MP0005025_abnormal_response_to2.26469409
15MP0003866_abnormal_defecation2.18687110
16MP0009785_altered_susceptibility_to2.17125332
17MP0005275_abnormal_skin_tensile2.14022110
18MP0004782_abnormal_surfactant_physiolog2.11707640
19MP0005166_decreased_susceptibility_to2.10016884
20MP0000465_gastrointestinal_hemorrhage2.09524155
21MP0005000_abnormal_immune_tolerance2.05629466
22MP0005671_abnormal_response_to1.95764300
23MP0001873_stomach_inflammation1.93986322
24MP0002452_abnormal_antigen_presenting1.91810685
25MP0002166_altered_tumor_susceptibility1.87113862
26MP0002148_abnormal_hypersensitivity_rea1.80663477
27MP0001533_abnormal_skeleton_physiology1.77630603
28MP0002723_abnormal_immune_serum1.74992439
29MP0002139_abnormal_hepatobiliary_system1.73608350
30MP0002138_abnormal_hepatobiliary_system1.73597984
31MP0005360_urolithiasis1.68858282
32MP0001819_abnormal_immune_cell1.68284283
33MP0003183_abnormal_peptide_metabolism1.68264201
34MP0002419_abnormal_innate_immunity1.68009582
35MP0002420_abnormal_adaptive_immunity1.67188228
36MP0004947_skin_inflammation1.66789899
37MP0001845_abnormal_inflammatory_respons1.63908633
38MP0001663_abnormal_digestive_system1.58671907
39MP0001666_abnormal_nutrient_absorption1.55783002
40MP0006082_CNS_inflammation1.51153695
41MP0005310_abnormal_salivary_gland1.48092475
42MP0003763_abnormal_thymus_physiology1.46200610
43MP0003191_abnormal_cellular_cholesterol1.45838986
44MP0004858_abnormal_nervous_system1.45716027
45MP0008004_abnormal_stomach_pH1.45013205
46MP0008438_abnormal_cutaneous_collagen1.40949415
47MP0005085_abnormal_gallbladder_physiolo1.39960496
48MP0003448_altered_tumor_morphology1.39926712
49MP0005503_abnormal_tendon_morphology1.39748827
50MP0002006_tumorigenesis1.36309913
51MP0000490_abnormal_crypts_of1.31436262
52MP0009333_abnormal_splenocyte_physiolog1.28009180
53MP0005023_abnormal_wound_healing1.27409866
54MP0000477_abnormal_intestine_morphology1.26159280
55MP0009840_abnormal_foam_cell1.25017418
56MP0000716_abnormal_immune_system1.24344321
57MP0002796_impaired_skin_barrier1.21903724
58MP0005381_digestive/alimentary_phenotyp1.20248924
59MP0003075_altered_response_to1.19531179
60MP0002398_abnormal_bone_marrow1.14556652
61MP0002998_abnormal_bone_remodeling1.14256874
62MP0003868_abnormal_feces_composition1.13658116
63MP0000604_amyloidosis1.11106868
64MP0001664_abnormal_digestion1.09487204
65MP0000858_altered_metastatic_potential1.09357290
66MP0005464_abnormal_platelet_physiology1.09320501
67MP0003045_fibrosis1.08976943
68MP0002405_respiratory_system_inflammati1.06555727
69MP0005365_abnormal_bile_salt1.03650068
70MP0000343_altered_response_to1.03347264
71MP0008469_abnormal_protein_level1.02816081
72MP0005451_abnormal_body_composition1.01219569
73MP0003453_abnormal_keratinocyte_physiol1.00464246
74MP0005409_darkened_coat_color0.99601353
75MP0003279_aneurysm0.98990045
76MP0002429_abnormal_blood_cell0.97851334
77MP0002009_preneoplasia0.94265094
78MP0002933_joint_inflammation0.92463671
79MP0003566_abnormal_cell_adhesion0.91848100
80MP0009764_decreased_sensitivity_to0.91412754
81MP0005390_skeleton_phenotype0.90988238
82MP0001851_eye_inflammation0.89210206
83MP0005164_abnormal_response_to0.88680143
84MP0000681_abnormal_thyroid_gland0.88183071
85MP0003329_amyloid_beta_deposits0.87846965
86MP0000249_abnormal_blood_vessel0.87825431
87MP0005058_abnormal_lysosome_morphology0.87691259
88MP0010678_abnormal_skin_adnexa0.87576319
89MP0000678_abnormal_parathyroid_gland0.87214956
90MP0009643_abnormal_urine_homeostasis0.87078068
91MP0002722_abnormal_immune_system0.85902932
92MP0000689_abnormal_spleen_morphology0.84021914
93MP0003091_abnormal_cell_migration0.83924324
94MP0005165_increased_susceptibility_to0.83272258
95MP0002896_abnormal_bone_mineralization0.82374044
96MP0003828_pulmonary_edema0.81744916
97MP0002876_abnormal_thyroid_physiology0.80462256
98MP0004019_abnormal_vitamin_homeostasis0.80016104
99MP0002136_abnormal_kidney_physiology0.79615272
100MP0001216_abnormal_epidermal_layer0.78110112

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.18103113
2Prostate neoplasm (HP:0100787)5.39874331
3Abnormality of macrophages (HP:0004311)4.61170679
4Eczematoid dermatitis (HP:0000976)4.46238443
5Malnutrition (HP:0004395)4.42993227
6Abnormality of complement system (HP:0005339)4.01259416
7Abnormality of the prostate (HP:0008775)3.89949574
8Glomerulonephritis (HP:0000099)3.79420894
9Complement deficiency (HP:0004431)3.77138379
10Vasculitis (HP:0002633)3.68602800
11Hyperactive renin-angiotensin system (HP:0000841)3.49407730
12Agammaglobulinemia (HP:0004432)3.48167670
13Recurrent bronchitis (HP:0002837)3.39444446
14Gastrointestinal stroma tumor (HP:0100723)3.38118141
15Colitis (HP:0002583)3.32316486
16Nephritis (HP:0000123)3.14200052
17Chronic diarrhea (HP:0002028)3.07931712
18Spontaneous hematomas (HP:0007420)3.01079995
19Abnormality of cells of the lymphoid lineage (HP:0012140)2.99327596
20Premature loss of primary teeth (HP:0006323)2.97702351
21Gastrointestinal infarctions (HP:0005244)2.91373917
22Recurrent bacterial skin infections (HP:0005406)2.91039256
23Cellulitis (HP:0100658)2.89222997
24Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88065718
25Inflammation of the large intestine (HP:0002037)2.87881339
26Alopecia of scalp (HP:0002293)2.86385851
27Skin rash (HP:0000988)2.86002149
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.85849219
29Meningitis (HP:0001287)2.85249358
30Increased IgE level (HP:0003212)2.76157752
31Abnormality of small intestinal villus morphology (HP:0011472)2.75030297
32Villous atrophy (HP:0011473)2.75030297
33Gastrointestinal inflammation (HP:0004386)2.74768875
34Gingivitis (HP:0000230)2.74100815
35Recurrent abscess formation (HP:0002722)2.72412039
36Osteomyelitis (HP:0002754)2.71285458
37Leukocytosis (HP:0001974)2.69443078
38Decreased circulating renin level (HP:0003351)2.68084339
39Right ventricular cardiomyopathy (HP:0011663)2.67310874
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59932021
41Urticaria (HP:0001025)2.54858649
42Chronic otitis media (HP:0000389)2.54327187
43Recurrent viral infections (HP:0004429)2.52892924
44Abnormality of B cell number (HP:0010975)2.48880567
45Emphysema (HP:0002097)2.48555679
46Abnormality of the nasal mucosa (HP:0000433)2.47485980
47Hemoptysis (HP:0002105)2.36626722
48Abnormal hair laboratory examination (HP:0003328)2.36077827
49Interstitial pulmonary disease (HP:0006530)2.34017318
50Myositis (HP:0100614)2.26517634
51Orchitis (HP:0100796)2.23715769
52Flat acetabular roof (HP:0003180)2.23553303
53Pili torti (HP:0003777)2.22624241
54Abnormality of male internal genitalia (HP:0000022)2.22454784
55Recurrent gram-negative bacterial infections (HP:0005420)2.18220515
56Mediastinal lymphadenopathy (HP:0100721)2.17079652
57Recurrent sinusitis (HP:0011108)2.17039734
58Abnormality of renin-angiotensin system (HP:0000847)2.16325166
59Neoplasm of the lung (HP:0100526)2.15874255
60Bronchitis (HP:0012387)2.15237438
61Pulmonary infiltrates (HP:0002113)2.13758621
62Metabolic alkalosis (HP:0200114)2.12337105
63Obstructive lung disease (HP:0006536)2.10720799
64Chronic obstructive pulmonary disease (HP:0006510)2.10720799
65Recurrent skin infections (HP:0001581)2.09614320
66Xerostomia (HP:0000217)2.09323761
67Recurrent fungal infections (HP:0002841)2.08282048
68Alkalosis (HP:0001948)2.05954984
69Hemorrhage of the eye (HP:0011885)2.04006390
70Periodontitis (HP:0000704)2.03054714
71Ileus (HP:0002595)2.02707957
72Hypergammaglobulinemia (HP:0010702)2.01724667
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.01227914
74Osteolytic defects of the hand bones (HP:0009699)2.01227914
75Pustule (HP:0200039)1.99899454
76Metaphyseal cupping (HP:0003021)1.99185493
77Skin ulcer (HP:0200042)1.98743082
78Restrictive lung disease (HP:0002091)1.98130267
79Elevated erythrocyte sedimentation rate (HP:0003565)1.96875194
80Recurrent pneumonia (HP:0006532)1.96133880
81Chronic mucocutaneous candidiasis (HP:0002728)1.94674108
82Recurrent cutaneous fungal infections (HP:0011370)1.94674108
83Segmental peripheral demyelination/remyelination (HP:0003481)1.94407410
84Ankyloglossia (HP:0010296)1.94282847
85Autoimmune hemolytic anemia (HP:0001890)1.94039543
86Purpura (HP:0000979)1.93757559
87B lymphocytopenia (HP:0010976)1.90111599
88Thick nail (HP:0001805)1.89898584
89Hypermelanotic macule (HP:0001034)1.89441088
90Recurrent lower respiratory tract infections (HP:0002783)1.89217905
91Panhypogammaglobulinemia (HP:0003139)1.89030438
92Nasal polyposis (HP:0100582)1.85381280
93Fragile skin (HP:0001030)1.85176877
94Hematochezia (HP:0002573)1.84947137
95Neoplasm of the respiratory system (HP:0100606)1.84678592
96Chest pain (HP:0100749)1.84235034
97Verrucae (HP:0200043)1.83252091
98Papilloma (HP:0012740)1.83252091
99Abnormality of T cell physiology (HP:0011840)1.82490915
100Atrophic scars (HP:0001075)1.82129168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.17099726
2TYK23.43509549
3MST1R3.38223141
4MAP4K13.12511534
5FGFR43.09990253
6PRPF4B2.76054667
7RIPK12.64660904
8RIPK42.57814320
9BLK2.46776096
10EPHA32.42835067
11JAK12.06841013
12MAP3K102.05003238
13EPHB11.97873979
14FGFR31.87788255
15ACVR1B1.87590967
16MAP3K141.86183440
17CDC42BPA1.82352078
18KIT1.73343514
19JAK31.67380591
20IKBKE1.61846050
21ZAP701.51837479
22PIK3CA1.50551371
23CSK1.41342446
24MAP3K11.36171877
25STK241.34939463
26GRK61.34349584
27IRAK41.30750395
28FES1.30492274
29EPHA21.29851229
30JAK21.25466310
31TBK11.24196134
32PDGFRA1.23691936
33MET1.20864406
34LYN1.14725505
35SYK1.13175884
36NLK1.13060193
37IRAK11.12022838
38PRKG21.08388388
39MAP3K131.08112112
40TXK1.05865771
41FER1.04073193
42BTK1.02949466
43SIK31.02750416
44TGFBR10.98700555
45MATK0.96502899
46TRIB30.93634911
47PTK60.91035528
48PKN20.90454330
49BMPR20.90042860
50TGFBR20.86321835
51CSF1R0.86102399
52YES10.85538261
53DDR20.82740673
54EPHB20.77939534
55HCK0.75983976
56TAOK10.75481884
57MAPK70.75336949
58STK390.74113610
59RET0.73561988
60MYLK0.73280314
61PDPK10.68267806
62CDK60.67961805
63LRRK20.65931953
64LMTK20.64585519
65KSR20.64299538
66LCK0.64096738
67MAP3K20.63815883
68MAPK110.63442523
69MAP3K30.63189367
70IKBKB0.62578468
71OXSR10.62003818
72MAP3K60.61701102
73FGR0.60502837
74DMPK0.58844800
75FYN0.55116653
76SMG10.54977760
77PDK10.53895492
78ITK0.53361620
79HIPK20.52573642
80TESK20.52429412
81EIF2AK30.52122851
82TAOK30.51034190
83PDGFRB0.50245265
84MAPKAPK20.50019068
85PDK20.47591235
86MAP2K30.47517458
87MAP2K20.46273091
88PAK40.45866937
89NEK90.41549034
90TEC0.41263297
91TESK10.38403757
92IRAK30.36204020
93MAP3K120.32725296
94PRKCQ0.32548818
95ABL10.30426929
96BMX0.30369582
97IGF1R0.29384188
98PRKCD0.28231492
99SRC0.28012473
100MELK0.27779701

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.69974987
2Asthma_Homo sapiens_hsa053103.53805448
3Allograft rejection_Homo sapiens_hsa053303.17482583
4Autoimmune thyroid disease_Homo sapiens_hsa053203.11405785
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.95299464
6Graft-versus-host disease_Homo sapiens_hsa053322.95225956
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.72304480
8Leishmaniasis_Homo sapiens_hsa051402.44372780
9Type I diabetes mellitus_Homo sapiens_hsa049402.42649446
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21573686
11Antigen processing and presentation_Homo sapiens_hsa046122.19105779
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10257087
13Viral myocarditis_Homo sapiens_hsa054161.85276988
14Renin-angiotensin system_Homo sapiens_hsa046141.58217960
15Pertussis_Homo sapiens_hsa051331.55546615
16Toxoplasmosis_Homo sapiens_hsa051451.54660663
17Primary immunodeficiency_Homo sapiens_hsa053401.52935183
18Arginine biosynthesis_Homo sapiens_hsa002201.52174928
19Sulfur metabolism_Homo sapiens_hsa009201.50741517
20Fat digestion and absorption_Homo sapiens_hsa049751.46396071
21B cell receptor signaling pathway_Homo sapiens_hsa046621.37777297
22Influenza A_Homo sapiens_hsa051641.36968757
23Osteoclast differentiation_Homo sapiens_hsa043801.34866679
24Tuberculosis_Homo sapiens_hsa051521.34816807
25Hematopoietic cell lineage_Homo sapiens_hsa046401.33867541
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31160169
27Other glycan degradation_Homo sapiens_hsa005111.30088260
28Rheumatoid arthritis_Homo sapiens_hsa053231.21374473
29Complement and coagulation cascades_Homo sapiens_hsa046101.15117574
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.11909760
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10306101
32Protein digestion and absorption_Homo sapiens_hsa049741.10011823
33Herpes simplex infection_Homo sapiens_hsa051681.08419220
34Mineral absorption_Homo sapiens_hsa049781.06431738
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05694861
36Fructose and mannose metabolism_Homo sapiens_hsa000511.05654827
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02787569
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00774193
39Phagosome_Homo sapiens_hsa041451.00222030
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99601318
41Hepatitis C_Homo sapiens_hsa051600.99034637
42Chemokine signaling pathway_Homo sapiens_hsa040620.94649770
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.93282224
44TNF signaling pathway_Homo sapiens_hsa046680.92191657
45Malaria_Homo sapiens_hsa051440.90173611
46Histidine metabolism_Homo sapiens_hsa003400.89731114
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.86632335
48Caffeine metabolism_Homo sapiens_hsa002320.86271143
49Starch and sucrose metabolism_Homo sapiens_hsa005000.83855196
50Measles_Homo sapiens_hsa051620.82667492
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82028533
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81219360
53African trypanosomiasis_Homo sapiens_hsa051430.80355988
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79046645
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76508973
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74635100
57Pancreatic secretion_Homo sapiens_hsa049720.73856553
58Arachidonic acid metabolism_Homo sapiens_hsa005900.72968750
59Systemic lupus erythematosus_Homo sapiens_hsa053220.71828470
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66975087
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.65928765
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65517349
63Amoebiasis_Homo sapiens_hsa051460.65457269
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63779229
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.63400242
66Retinol metabolism_Homo sapiens_hsa008300.63092004
67Acute myeloid leukemia_Homo sapiens_hsa052210.60851969
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60677218
69Vitamin digestion and absorption_Homo sapiens_hsa049770.58765008
70Galactose metabolism_Homo sapiens_hsa000520.53586476
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53514241
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52854332
73Pancreatic cancer_Homo sapiens_hsa052120.52786631
74PPAR signaling pathway_Homo sapiens_hsa033200.49876588
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49768447
76Apoptosis_Homo sapiens_hsa042100.48162278
77Linoleic acid metabolism_Homo sapiens_hsa005910.47821140
78Chemical carcinogenesis_Homo sapiens_hsa052040.47535682
79Lysosome_Homo sapiens_hsa041420.46481872
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46339224
81Thyroid hormone synthesis_Homo sapiens_hsa049180.46249619
82Arginine and proline metabolism_Homo sapiens_hsa003300.45732345
83Hepatitis B_Homo sapiens_hsa051610.45668401
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44627453
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44256077
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42286986
87Nitrogen metabolism_Homo sapiens_hsa009100.41451572
88Salmonella infection_Homo sapiens_hsa051320.40526154
89Fatty acid degradation_Homo sapiens_hsa000710.39476094
90Ether lipid metabolism_Homo sapiens_hsa005650.39092208
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38064283
92T cell receptor signaling pathway_Homo sapiens_hsa046600.37880312
93HTLV-I infection_Homo sapiens_hsa051660.37525159
94Prolactin signaling pathway_Homo sapiens_hsa049170.37236114
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37164892
96Platelet activation_Homo sapiens_hsa046110.36878083
97Prion diseases_Homo sapiens_hsa050200.35960159
98Bile secretion_Homo sapiens_hsa049760.35891348
99Chronic myeloid leukemia_Homo sapiens_hsa052200.33867018
100Sphingolipid metabolism_Homo sapiens_hsa006000.27556676

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