IGKV4-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* complement activation, classical pathway (GO:0006958)9.17075161
2positive regulation of respiratory burst (GO:0060267)7.33935318
3* complement activation (GO:0006956)7.25895460
4glomerular filtration (GO:0003094)6.54833706
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.34800780
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.31118029
7antigen processing and presentation of endogenous antigen (GO:0019883)6.21003314
8renal filtration (GO:0097205)5.88669749
9regulation of respiratory burst (GO:0060263)5.44253516
10* protein activation cascade (GO:0072376)5.32352374
11antibacterial humoral response (GO:0019731)5.24337123
12antimicrobial humoral response (GO:0019730)5.19825157
13* humoral immune response (GO:0006959)4.76780068
14regulation of dendritic cell antigen processing and presentation (GO:0002604)4.75554207
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64336385
16* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.46470408
17* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.46470408
18* Fc-gamma receptor signaling pathway (GO:0038094)4.46470408
19regulation of cellular extravasation (GO:0002691)4.46410825
20* Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.44091803
21immunoglobulin mediated immune response (GO:0016064)4.26053885
22positive regulation of antigen processing and presentation (GO:0002579)3.98716608
23regulation of antigen processing and presentation (GO:0002577)3.97791246
24detection of bacterium (GO:0016045)3.91701612
25interferon-gamma-mediated signaling pathway (GO:0060333)3.87775245
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.78725718
27detection of other organism (GO:0098543)3.77453899
28negative regulation of cell killing (GO:0031342)3.76584767
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76584767
30retina homeostasis (GO:0001895)3.61781401
31cellular response to type I interferon (GO:0071357)3.58018808
32type I interferon signaling pathway (GO:0060337)3.58018808
33response to type I interferon (GO:0034340)3.55667081
34germinal center formation (GO:0002467)3.53920574
35angiotensin maturation (GO:0002003)3.52407253
36positive regulation of gamma-delta T cell activation (GO:0046645)3.47020395
37positive regulation of pseudopodium assembly (GO:0031274)3.35933091
38B cell mediated immunity (GO:0019724)3.29581347
39* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.25149963
40positive regulation of B cell differentiation (GO:0045579)3.21138343
41B cell receptor signaling pathway (GO:0050853)3.20585402
42negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.12833019
43cellular response to interferon-gamma (GO:0071346)3.06417429
44positive regulation of Cdc42 GTPase activity (GO:0043089)2.98708864
45NIK/NF-kappaB signaling (GO:0038061)2.97822503
46regulation of pseudopodium assembly (GO:0031272)2.97775061
47response to interleukin-15 (GO:0070672)2.97001501
48dendritic cell chemotaxis (GO:0002407)2.93695841
49peptide catabolic process (GO:0043171)2.86254992
50response to interferon-gamma (GO:0034341)2.86054969
51T-helper 1 type immune response (GO:0042088)2.85475439
52cellular response to interleukin-15 (GO:0071350)2.85236889
53detection of external biotic stimulus (GO:0098581)2.84542607
54chronic inflammatory response (GO:0002544)2.83983670
55positive thymic T cell selection (GO:0045059)2.83423329
56regulation of B cell receptor signaling pathway (GO:0050855)2.79262174
57production of molecular mediator of immune response (GO:0002440)2.78507730
58regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.76732749
59surfactant homeostasis (GO:0043129)2.76203723
60regulation of integrin activation (GO:0033623)2.75493735
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74617078
62adhesion of symbiont to host cell (GO:0044650)2.74271011
63virion attachment to host cell (GO:0019062)2.74271011
64regulation of T cell tolerance induction (GO:0002664)2.72474410
65regulation of vitamin metabolic process (GO:0030656)2.70745428
66regulation of guanylate cyclase activity (GO:0031282)2.69904960
67T cell costimulation (GO:0031295)2.63348262
68positive regulation of granulocyte chemotaxis (GO:0071624)2.60787543
69chaperone mediated protein folding requiring cofactor (GO:0051085)2.60629647
70interferon-gamma secretion (GO:0072643)2.60083729
71myeloid dendritic cell differentiation (GO:0043011)2.59499383
72lymphocyte costimulation (GO:0031294)2.59275991
73maintenance of gastrointestinal epithelium (GO:0030277)2.58534496
74intestinal absorption (GO:0050892)2.58347971
75mature B cell differentiation involved in immune response (GO:0002313)2.57495999
76positive regulation of neutrophil chemotaxis (GO:0090023)2.55943372
77positive regulation of neutrophil migration (GO:1902624)2.55943372
78regulation of gamma-delta T cell activation (GO:0046643)2.55747159
79* immune response-activating signal transduction (GO:0002757)2.53514713
80* activation of immune response (GO:0002253)2.52074573
81regulation of B cell differentiation (GO:0045577)2.51591458
82glycosphingolipid catabolic process (GO:0046479)2.50514790
83protein-chromophore linkage (GO:0018298)2.47912056
84regulation of tolerance induction (GO:0002643)2.47810221
85myeloid dendritic cell activation (GO:0001773)2.45503648
86regulation of regulatory T cell differentiation (GO:0045589)2.43598514
87dendritic cell migration (GO:0036336)2.43409971
88negative regulation of myotube differentiation (GO:0010832)2.41565904
89antigen processing and presentation via MHC class Ib (GO:0002475)2.41559842
90negative regulation of innate immune response (GO:0045824)2.41529282
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39536835
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39536835
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.39536835
94modulation by symbiont of host immune response (GO:0052553)2.39536835
95positive regulation by symbiont of host defense response (GO:0052509)2.39536835
96modulation by symbiont of host defense response (GO:0052031)2.39536835
97defense response to protozoan (GO:0042832)2.35912750
98regulation of necrotic cell death (GO:0010939)2.35893472
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35764788
100detection of biotic stimulus (GO:0009595)2.35602003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.15301170
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.13228194
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.77509857
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.30361406
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.22856831
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.00983173
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95923595
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74629120
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.40741632
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25381346
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23541440
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.20657744
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09206021
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05853734
15E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03067065
16STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96888447
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94784273
18RUNX_20019798_ChIP-Seq_JUKART_Human1.92182458
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85520924
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75054290
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74881757
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.73047559
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72601104
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69807673
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67192971
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64762185
27MYC_22102868_ChIP-Seq_BL_Human1.64350476
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64120200
29MYB_26560356_Chip-Seq_TH2_Human1.63763607
30VDR_24763502_ChIP-Seq_THP-1_Human1.59265052
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.58828845
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56753315
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55337959
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52895883
35MYB_26560356_Chip-Seq_TH1_Human1.45278981
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44992603
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43327337
38SOX2_20726797_ChIP-Seq_SW620_Human1.41862148
39MAF_26560356_Chip-Seq_TH1_Human1.38917556
40LXR_22292898_ChIP-Seq_THP-1_Human1.36178223
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34654385
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.33544550
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32995923
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32375450
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.31268962
46VDR_21846776_ChIP-Seq_THP-1_Human1.30982812
47EGR1_19032775_ChIP-ChIP_M12_Human1.28344805
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26730878
49CLOCK_20551151_ChIP-Seq_293T_Human1.26308654
50SPI1_23127762_ChIP-Seq_K562_Human1.26133779
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25410362
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24545968
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24513245
54SPI1_23547873_ChIP-Seq_NB4_Human1.24482174
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24226373
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24210386
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.23276766
58VDR_24787735_ChIP-Seq_THP-1_Human1.23180675
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22575799
60GATA4_25053715_ChIP-Seq_YYC3_Human1.20193168
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.19611212
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.16838071
63SCL_19346495_ChIP-Seq_HPC-7_Human1.16282201
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15118009
65TCF7_22412390_ChIP-Seq_EML_Mouse1.14681483
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.13762091
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13372257
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13275844
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12829041
70UTX_26944678_Chip-Seq_JUKART_Human1.12783562
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09479458
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07018642
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05055010
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04316890
75GATA1_19941826_ChIP-Seq_K562_Human1.04156235
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03437226
77GATA6_25053715_ChIP-Seq_YYC3_Human1.02218747
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01609382
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01113029
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00903017
81GATA1_22025678_ChIP-Seq_K562_Human1.00460539
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99947054
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99191924
84GATA3_27048872_Chip-Seq_THYMUS_Human0.98388170
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.98064793
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97244849
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.97221033
88GATA2_19941826_ChIP-Seq_K562_Human0.92804535
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91998430
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91752983
91RACK7_27058665_Chip-Seq_MCF-7_Human0.91194454
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90778772
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90416799
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90244599
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.87642160
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86260739
97BCOR_27268052_Chip-Seq_Bcells_Human0.83935487
98RUNX1_27514584_Chip-Seq_MCF-7_Human0.83036774
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81860501
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.81226189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.79249172
2MP0001835_abnormal_antigen_presentation3.67927324
3MP0003303_peritoneal_inflammation3.62035139
4MP0000685_abnormal_immune_system3.36157490
5MP0005387_immune_system_phenotype3.33284450
6MP0001790_abnormal_immune_system3.33284450
7MP0010155_abnormal_intestine_physiology3.00980623
8MP0003436_decreased_susceptibility_to3.00554501
9MP0001800_abnormal_humoral_immune2.88206599
10MP0010234_abnormal_vibrissa_follicle2.78607776
11MP0005671_abnormal_response_to2.67843548
12MP0004264_abnormal_extraembryonic_tissu2.57206393
13MP0005025_abnormal_response_to2.47422573
14MP0005000_abnormal_immune_tolerance2.42504484
15MP0009785_altered_susceptibility_to2.40212851
16MP0002452_abnormal_antigen_presenting2.18127303
17MP0002148_abnormal_hypersensitivity_rea2.14478593
18MP0003866_abnormal_defecation2.09190438
19MP0002166_altered_tumor_susceptibility2.04890007
20MP0003300_gastrointestinal_ulcer2.03987316
21MP0002723_abnormal_immune_serum2.03938351
22MP0005275_abnormal_skin_tensile1.94963675
23MP0001819_abnormal_immune_cell1.92894511
24MP0002420_abnormal_adaptive_immunity1.91876057
25MP0000465_gastrointestinal_hemorrhage1.90333307
26MP0003183_abnormal_peptide_metabolism1.86873083
27MP0002138_abnormal_hepatobiliary_system1.80896813
28MP0002419_abnormal_innate_immunity1.79425406
29MP0004947_skin_inflammation1.77884898
30MP0010352_gastrointestinal_tract_polyps1.76615215
31MP0001533_abnormal_skeleton_physiology1.74386445
32MP0003763_abnormal_thymus_physiology1.73924831
33MP0005166_decreased_susceptibility_to1.73067798
34MP0001845_abnormal_inflammatory_respons1.71533455
35MP0001873_stomach_inflammation1.71305055
36MP0002139_abnormal_hepatobiliary_system1.69154479
37MP0005360_urolithiasis1.60260096
38MP0009333_abnormal_splenocyte_physiolog1.59643890
39MP0004782_abnormal_surfactant_physiolog1.57587945
40MP0002006_tumorigenesis1.46413276
41MP0000716_abnormal_immune_system1.45532064
42MP0001663_abnormal_digestive_system1.44753731
43MP0006082_CNS_inflammation1.44401882
44MP0001666_abnormal_nutrient_absorption1.36947875
45MP0005310_abnormal_salivary_gland1.34696463
46MP0002398_abnormal_bone_marrow1.33318581
47MP0005085_abnormal_gallbladder_physiolo1.29888146
48MP0003448_altered_tumor_morphology1.27756532
49MP0008438_abnormal_cutaneous_collagen1.23495396
50MP0003191_abnormal_cellular_cholesterol1.20287402
51MP0003075_altered_response_to1.19971966
52MP0005503_abnormal_tendon_morphology1.18873555
53MP0004858_abnormal_nervous_system1.17890172
54MP0002796_impaired_skin_barrier1.17858505
55MP0005464_abnormal_platelet_physiology1.16796214
56MP0008260_abnormal_autophagy1.16687076
57MP0002429_abnormal_blood_cell1.15685608
58MP0005409_darkened_coat_color1.14931938
59MP0000477_abnormal_intestine_morphology1.12763266
60MP0008004_abnormal_stomach_pH1.11048477
61MP0000490_abnormal_crypts_of1.09954963
62MP0005023_abnormal_wound_healing1.09569492
63MP0009764_decreased_sensitivity_to1.07611900
64MP0005381_digestive/alimentary_phenotyp1.05020193
65MP0002998_abnormal_bone_remodeling1.04817729
66MP0003045_fibrosis1.04688929
67MP0002933_joint_inflammation1.04622123
68MP0002405_respiratory_system_inflammati1.04199197
69MP0008469_abnormal_protein_level1.03323601
70MP0009840_abnormal_foam_cell1.03278915
71MP0000689_abnormal_spleen_morphology1.02060767
72MP0005365_abnormal_bile_salt1.01910995
73MP0000604_amyloidosis1.01740783
74MP0000249_abnormal_blood_vessel1.01728036
75MP0001879_abnormal_lymphatic_vessel1.01226709
76MP0000858_altered_metastatic_potential0.99915346
77MP0002722_abnormal_immune_system0.98329154
78MP0000343_altered_response_to0.97947516
79MP0004019_abnormal_vitamin_homeostasis0.96364668
80MP0005451_abnormal_body_composition0.95659107
81MP0003453_abnormal_keratinocyte_physiol0.95312334
82MP0002136_abnormal_kidney_physiology0.94227691
83MP0005165_increased_susceptibility_to0.92402121
84MP0001851_eye_inflammation0.88869288
85MP0003279_aneurysm0.87236609
86MP0003868_abnormal_feces_composition0.85851938
87MP0009643_abnormal_urine_homeostasis0.82764697
88MP0005390_skeleton_phenotype0.81569754
89MP0001664_abnormal_digestion0.80728558
90MP0009278_abnormal_bone_marrow0.77556411
91MP0003091_abnormal_cell_migration0.74935382
92MP0005164_abnormal_response_to0.74714869
93MP0001958_emphysema0.74138119
94MP0003329_amyloid_beta_deposits0.73627438
95MP0003828_pulmonary_edema0.72813707
96MP0002876_abnormal_thyroid_physiology0.71458889
97MP0002098_abnormal_vibrissa_morphology0.70008836
98MP0003011_delayed_dark_adaptation0.68313290
99MP0003566_abnormal_cell_adhesion0.67279068
100MP0002396_abnormal_hematopoietic_system0.67221922

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.49317989
2Agammaglobulinemia (HP:0004432)5.67012213
3Eczematoid dermatitis (HP:0000976)4.49798047
4Recurrent bronchitis (HP:0002837)4.43655510
5Malnutrition (HP:0004395)4.28570711
6Gastrointestinal stroma tumor (HP:0100723)4.22691273
7Prostate neoplasm (HP:0100787)4.18190996
8Cellulitis (HP:0100658)4.14099316
9Abnormality of macrophages (HP:0004311)4.09772281
10Glomerulonephritis (HP:0000099)3.98350256
11Abnormality of complement system (HP:0005339)3.96467900
12Chronic diarrhea (HP:0002028)3.91787649
13Colitis (HP:0002583)3.88517146
14Vasculitis (HP:0002633)3.85100131
15Complement deficiency (HP:0004431)3.76337438
16Meningitis (HP:0001287)3.62312803
17Recurrent sinusitis (HP:0011108)3.44928401
18Osteomyelitis (HP:0002754)3.43491907
19Abnormality of the prostate (HP:0008775)3.31046105
20Emphysema (HP:0002097)3.26666254
21Chronic sinusitis (HP:0011109)3.24697018
22Skin rash (HP:0000988)3.24275921
23Recurrent pneumonia (HP:0006532)3.23618557
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.23228675
25Nephritis (HP:0000123)3.22335569
26Inflammation of the large intestine (HP:0002037)3.14855802
27Recurrent bacterial skin infections (HP:0005406)3.05577165
28Spontaneous hematomas (HP:0007420)3.04680048
29Gastrointestinal inflammation (HP:0004386)2.97042352
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.96419049
31Verrucae (HP:0200043)2.94417089
32Papilloma (HP:0012740)2.94417089
33Increased IgE level (HP:0003212)2.90371350
34Abnormality of B cell number (HP:0010975)2.89685662
35Recurrent abscess formation (HP:0002722)2.84186341
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.80091951
37Alopecia of scalp (HP:0002293)2.79680250
38Chronic otitis media (HP:0000389)2.79363921
39Gastrointestinal infarctions (HP:0005244)2.77652468
40Recurrent lower respiratory tract infections (HP:0002783)2.75145389
41Abnormality of the nasal mucosa (HP:0000433)2.71826422
42Recurrent viral infections (HP:0004429)2.68628684
43Obstructive lung disease (HP:0006536)2.57484357
44Chronic obstructive pulmonary disease (HP:0006510)2.57484357
45Bronchitis (HP:0012387)2.56583972
46Sepsis (HP:0100806)2.56012913
47Gingivitis (HP:0000230)2.55404635
48Premature loss of primary teeth (HP:0006323)2.50791981
49Hemoptysis (HP:0002105)2.49321528
50Leukocytosis (HP:0001974)2.49309764
51Orchitis (HP:0100796)2.47797758
52Myositis (HP:0100614)2.46402411
53B lymphocytopenia (HP:0010976)2.44246908
54Urticaria (HP:0001025)2.43863928
55Lymphopenia (HP:0001888)2.43242943
56Elevated erythrocyte sedimentation rate (HP:0003565)2.41989753
57Hyperactive renin-angiotensin system (HP:0000841)2.39995364
58Pulmonary infiltrates (HP:0002113)2.39854086
59Mediastinal lymphadenopathy (HP:0100721)2.39177157
60Recurrent gram-negative bacterial infections (HP:0005420)2.35628173
61Restrictive lung disease (HP:0002091)2.34114606
62Pustule (HP:0200039)2.32696291
63Abnormality of small intestinal villus morphology (HP:0011472)2.27969656
64Villous atrophy (HP:0011473)2.27969656
65Recurrent fungal infections (HP:0002841)2.27235909
66Skin ulcer (HP:0200042)2.21872950
67Decreased circulating renin level (HP:0003351)2.21435237
68Hemorrhage of the eye (HP:0011885)2.19946317
69Hematochezia (HP:0002573)2.16477428
70Recurrent skin infections (HP:0001581)2.15467828
71Nasal polyposis (HP:0100582)2.13588183
72Segmental peripheral demyelination/remyelination (HP:0003481)2.11639413
73Right ventricular cardiomyopathy (HP:0011663)2.11291207
74Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10578795
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07730003
76Recurrent otitis media (HP:0000403)2.04412251
77Persistence of primary teeth (HP:0006335)2.02750607
78Ileus (HP:0002595)2.02367943
79Abnormality of T cell physiology (HP:0011840)2.02238355
80Purpura (HP:0000979)2.02140114
81Panhypogammaglobulinemia (HP:0003139)2.01763971
82Recurrent cutaneous fungal infections (HP:0011370)2.00976235
83Chronic mucocutaneous candidiasis (HP:0002728)2.00976235
84Retrobulbar optic neuritis (HP:0100654)2.00921354
85Optic neuritis (HP:0100653)2.00921354
86Dehydration (HP:0001944)1.92546123
87IgM deficiency (HP:0002850)1.92164979
88Interstitial pulmonary disease (HP:0006530)1.91925476
89Thyroiditis (HP:0100646)1.91916809
90Chest pain (HP:0100749)1.91183490
91Flat acetabular roof (HP:0003180)1.90851665
92Hypergammaglobulinemia (HP:0010702)1.88848462
93IgA deficiency (HP:0002720)1.87480996
94Neoplasm of the lung (HP:0100526)1.87279444
95Conjunctival telangiectasia (HP:0000524)1.87105030
96Metabolic alkalosis (HP:0200114)1.86463978
97Encephalitis (HP:0002383)1.85886954
98Nausea (HP:0002018)1.85202188
99Abnormality of male internal genitalia (HP:0000022)1.85144119
100Autoimmune thrombocytopenia (HP:0001973)1.83716261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.31215425
2PDK23.97308038
3TYK23.42209823
4MAP4K13.21611140
5TESK23.05334246
6FGFR42.80357308
7BLK2.73336101
8RIPK42.60066365
9MST1R2.53969623
10JAK12.13159665
11RIPK12.11057030
12PRPF4B2.01261942
13JAK31.99058159
14MAP3K141.97896933
15EPHA31.92920983
16KIT1.87852162
17IRAK41.83805425
18IKBKE1.75368709
19FGFR31.68496400
20ACVR1B1.63765451
21CDC42BPA1.58912951
22SYK1.58890765
23EPHB11.52929480
24TBK11.51516520
25MAP3K101.49453213
26MAPKAPK31.46844337
27SIK31.43121401
28ZAP701.37428063
29CSK1.33853059
30CSF1R1.30556445
31MAPK71.30109343
32IRAK11.26820339
33BTK1.26179953
34MAP3K131.23751462
35LYN1.18556462
36GRK61.17523086
37HCK1.17128134
38FES1.13594989
39PIK3CA1.11964301
40TGFBR21.11142372
41BMPR21.09541049
42MAP3K10.99760589
43JAK20.99603801
44NEK60.98079020
45PRKG20.94652208
46MST40.94088112
47STK240.93499235
48GRK10.91543385
49PDGFRA0.91218618
50TXK0.90381481
51MATK0.88228648
52MAPK120.86493952
53PDPK10.85178491
54EPHA20.85155892
55MAP2K20.84863943
56MET0.80271361
57DDR20.79546791
58SMG10.79442879
59TRIB30.78103545
60EPHB20.76934330
61PKN20.75915496
62FER0.74006736
63LCK0.73859713
64IKBKB0.71336668
65HIPK20.69594525
66LRRK20.68150426
67NLK0.67833977
68PDK10.65868315
69PTK60.64977670
70MAPK110.64945424
71MYLK0.61909172
72ITK0.59654078
73FYN0.58133661
74CDK60.57477427
75FGR0.51376371
76TAOK10.49163800
77MAP3K30.47465621
78MAPKAPK20.47310313
79RET0.47001846
80MAP3K110.46139129
81KDR0.44977243
82TGFBR10.44933183
83PRKCQ0.43389794
84SIK10.38696560
85EIF2AK30.38530323
86IGF1R0.37753044
87YES10.37412222
88TEC0.35262955
89ABL10.34646185
90BMX0.34438699
91MAP3K20.34064775
92MAP2K30.33715171
93SIK20.33420292
94PDGFRB0.31685876
95PRKCD0.30455225
96OXSR10.30297817
97SRC0.29503411
98STK390.28160083
99TNK20.27935295
100PRKD20.26054496

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.88300344
2Staphylococcus aureus infection_Homo sapiens_hsa051503.70053997
3Allograft rejection_Homo sapiens_hsa053303.57024846
4Autoimmune thyroid disease_Homo sapiens_hsa053203.31366355
5Graft-versus-host disease_Homo sapiens_hsa053323.31218516
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.17601149
7Type I diabetes mellitus_Homo sapiens_hsa049402.77221896
8Leishmaniasis_Homo sapiens_hsa051402.54716688
9Antigen processing and presentation_Homo sapiens_hsa046122.42461409
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41507536
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.30565077
12Primary immunodeficiency_Homo sapiens_hsa053402.25273890
13Viral myocarditis_Homo sapiens_hsa054162.05877762
14B cell receptor signaling pathway_Homo sapiens_hsa046621.75085722
15Toxoplasmosis_Homo sapiens_hsa051451.63894690
16Pertussis_Homo sapiens_hsa051331.48376621
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47750313
18Hematopoietic cell lineage_Homo sapiens_hsa046401.46852282
19Osteoclast differentiation_Homo sapiens_hsa043801.46737165
20Tuberculosis_Homo sapiens_hsa051521.46674798
21Influenza A_Homo sapiens_hsa051641.42818360
22Systemic lupus erythematosus_Homo sapiens_hsa053221.42094983
23Renin-angiotensin system_Homo sapiens_hsa046141.41834232
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.40717485
25Fat digestion and absorption_Homo sapiens_hsa049751.38200109
26Sulfur metabolism_Homo sapiens_hsa009201.35663554
27Rheumatoid arthritis_Homo sapiens_hsa053231.33874560
28Herpes simplex infection_Homo sapiens_hsa051681.14713617
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06451918
30Other glycan degradation_Homo sapiens_hsa005111.05529796
31Complement and coagulation cascades_Homo sapiens_hsa046101.04714227
32Arginine biosynthesis_Homo sapiens_hsa002201.04056850
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03808881
34Chemokine signaling pathway_Homo sapiens_hsa040621.02663689
35Phagosome_Homo sapiens_hsa041451.02449047
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97209639
37Malaria_Homo sapiens_hsa051440.93918890
38Hepatitis C_Homo sapiens_hsa051600.91526742
39TNF signaling pathway_Homo sapiens_hsa046680.90683101
40Fructose and mannose metabolism_Homo sapiens_hsa000510.89129557
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88325724
42Protein digestion and absorption_Homo sapiens_hsa049740.86680317
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85014690
44Arachidonic acid metabolism_Homo sapiens_hsa005900.83601279
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83292226
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83107534
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.81722794
48Mineral absorption_Homo sapiens_hsa049780.79654935
49African trypanosomiasis_Homo sapiens_hsa051430.79469666
50Measles_Homo sapiens_hsa051620.79243007
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74638109
52Vitamin digestion and absorption_Homo sapiens_hsa049770.73131967
53Galactose metabolism_Homo sapiens_hsa000520.72389656
54PPAR signaling pathway_Homo sapiens_hsa033200.70531163
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.70441056
56Linoleic acid metabolism_Homo sapiens_hsa005910.69622762
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69405688
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67927834
59Histidine metabolism_Homo sapiens_hsa003400.66573211
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65716067
61Caffeine metabolism_Homo sapiens_hsa002320.65592213
62Ether lipid metabolism_Homo sapiens_hsa005650.60387697
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59146347
64Amoebiasis_Homo sapiens_hsa051460.56598294
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56338175
66Retinol metabolism_Homo sapiens_hsa008300.56294916
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56074970
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54816223
69Pancreatic secretion_Homo sapiens_hsa049720.53288629
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52849129
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.51943420
72Acute myeloid leukemia_Homo sapiens_hsa052210.51279327
73Starch and sucrose metabolism_Homo sapiens_hsa005000.51112453
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48384031
75Legionellosis_Homo sapiens_hsa051340.48056811
76Apoptosis_Homo sapiens_hsa042100.47352866
77Pancreatic cancer_Homo sapiens_hsa052120.46259967
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44320633
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43799639
80HTLV-I infection_Homo sapiens_hsa051660.43436781
81Lysosome_Homo sapiens_hsa041420.42542661
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42234897
83Hepatitis B_Homo sapiens_hsa051610.41498719
84Glycerolipid metabolism_Homo sapiens_hsa005610.40997163
85Platelet activation_Homo sapiens_hsa046110.40930420
86T cell receptor signaling pathway_Homo sapiens_hsa046600.39395448
87Epstein-Barr virus infection_Homo sapiens_hsa051690.38539146
88Salmonella infection_Homo sapiens_hsa051320.35224402
89Viral carcinogenesis_Homo sapiens_hsa052030.33757111
90Nitrogen metabolism_Homo sapiens_hsa009100.32071958
91Prion diseases_Homo sapiens_hsa050200.31111886
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.30755820
93VEGF signaling pathway_Homo sapiens_hsa043700.29316603
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29261473
95Bile secretion_Homo sapiens_hsa049760.29091677
96Prolactin signaling pathway_Homo sapiens_hsa049170.28603212
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28580583
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28396400
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.27772851
100Thyroid hormone synthesis_Homo sapiens_hsa049180.25161846

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