IGLC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* complement activation (GO:0006956)9.76266211
2antigen processing and presentation of endogenous antigen (GO:0019883)9.01522072
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.80120753
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.80120753
5negative regulation of glucose import (GO:0046325)7.69180033
6B cell receptor signaling pathway (GO:0050853)7.47250905
7signal peptide processing (GO:0006465)6.93859275
8negative regulation of B cell proliferation (GO:0030889)6.36171610
9positive regulation of respiratory burst (GO:0060267)6.35314706
10* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)6.33859053
11* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00026.33859053
12* Fc-gamma receptor signaling pathway (GO:0038094)6.33859053
13* Fc receptor mediated stimulatory signaling pathway (GO:0002431)6.25123213
14* protein activation cascade (GO:0072376)6.24429797
15negative regulation of glucose transport (GO:0010829)6.23608790
16regulation of glucose import in response to insulin stimulus (GO:2001273)5.93602851
17* humoral immune response (GO:0006959)5.87490085
18regulation of B cell proliferation (GO:0030888)5.55514650
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.54754378
20regulation of B cell receptor signaling pathway (GO:0050855)5.47108884
21positive regulation of B cell differentiation (GO:0045579)5.41011467
22regulation of B cell differentiation (GO:0045577)5.30199824
23retina homeostasis (GO:0001895)5.23346376
24mesoderm development (GO:0007498)5.15942828
25cellular response to zinc ion (GO:0071294)4.77473908
26* immune response-activating cell surface receptor signaling pathway (GO:0002429)4.68447600
27glomerular filtration (GO:0003094)4.67897489
28N-acetylneuraminate metabolic process (GO:0006054)4.56969478
29mesenchyme development (GO:0060485)4.55858176
30mature B cell differentiation (GO:0002335)4.55265258
31positive regulation of gamma-delta T cell activation (GO:0046645)4.53156379
32B cell proliferation (GO:0042100)4.51495892
33regulation of respiratory burst (GO:0060263)4.39939688
34positive regulation of immunoglobulin production (GO:0002639)4.34745927
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.34070809
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.28069066
37regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.23512988
38renal filtration (GO:0097205)4.17981654
39regulation of interferon-beta biosynthetic process (GO:0045357)4.13108074
40positive regulation of Rap GTPase activity (GO:0032854)4.09632966
41antimicrobial humoral response (GO:0019730)4.09458240
42L-fucose metabolic process (GO:0042354)4.08688721
43L-fucose catabolic process (GO:0042355)4.08688721
44fucose catabolic process (GO:0019317)4.08688721
45respiratory burst (GO:0045730)4.01979741
46gonadal mesoderm development (GO:0007506)37.3605667
47antibacterial humoral response (GO:0019731)3.95224374
48mature B cell differentiation involved in immune response (GO:0002313)3.94839881
49regulation of B cell activation (GO:0050864)3.88922862
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.76081898
51apoptotic cell clearance (GO:0043277)3.75506460
52regulation of B cell apoptotic process (GO:0002902)3.73262366
53B cell homeostasis (GO:0001782)3.73188047
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70481697
55regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.69118309
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.63586184
57exocrine pancreas development (GO:0031017)3.61132493
58antigen receptor-mediated signaling pathway (GO:0050851)3.52871036
59cytidine catabolic process (GO:0006216)3.42819314
60cytidine deamination (GO:0009972)3.42819314
61cytidine metabolic process (GO:0046087)3.42819314
62regulation of Rap GTPase activity (GO:0032317)3.41482100
63* immune response-activating signal transduction (GO:0002757)3.39815893
64regulation of gamma-delta T cell differentiation (GO:0045586)3.38232811
65endoplasmic reticulum unfolded protein response (GO:0030968)3.37920076
66regulation of cellular extravasation (GO:0002691)3.37601797
67regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.34256636
68natural killer cell mediated immunity (GO:0002228)3.33886175
69natural killer cell mediated cytotoxicity (GO:0042267)3.33886175
70activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.32097439
71protein N-linked glycosylation via asparagine (GO:0018279)3.28437222
72negative regulation of cellular response to insulin stimulus (GO:1900077)3.26632191
73cellular response to antibiotic (GO:0071236)3.25710515
74positive regulation of nuclease activity (GO:0032075)3.25365552
75B cell activation (GO:0042113)3.25313217
76peptidyl-asparagine modification (GO:0018196)3.24880343
77positive regulation of B cell proliferation (GO:0030890)3.24136489
78regulation of immunoglobulin production (GO:0002637)3.23651308
79negative regulation of B cell activation (GO:0050869)3.23570233
80cellular response to unfolded protein (GO:0034620)3.22771813
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21831255
82positive regulation of antigen processing and presentation (GO:0002579)3.21638253
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20085849
84NADH metabolic process (GO:0006734)3.18034849
85regulation of nuclease activity (GO:0032069)3.17120003
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15404406
87cellular response to type I interferon (GO:0071357)3.12831037
88type I interferon signaling pathway (GO:0060337)3.12831037
89regulation of antigen processing and presentation (GO:0002577)3.10977077
90response to type I interferon (GO:0034340)3.10294583
91defense response to Gram-negative bacterium (GO:0050829)3.09438675
92positive regulation of B cell activation (GO:0050871)3.09368212
93defense response to protozoan (GO:0042832)3.07808635
94* activation of immune response (GO:0002253)3.06761922
95negative T cell selection (GO:0043383)3.06243809
96response to endoplasmic reticulum stress (GO:0034976)3.05506865
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05426595
98somatic hypermutation of immunoglobulin genes (GO:0016446)3.05299303
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05299303
100negative thymic T cell selection (GO:0045060)3.04795682
101immunoglobulin mediated immune response (GO:0016064)3.04769685
102phenylpropanoid metabolic process (GO:0009698)3.04672206
103Golgi transport vesicle coating (GO:0048200)3.03806405
104COPI coating of Golgi vesicle (GO:0048205)3.03806405
105positive thymic T cell selection (GO:0045059)3.03480523
106I-kappaB phosphorylation (GO:0007252)3.03362051
107cellular response to topologically incorrect protein (GO:0035967)3.01288352
108regulation of gamma-delta T cell activation (GO:0046643)3.00935582
109* immune response-regulating cell surface receptor signaling pathway (GO:0002768)3.00681305
110protein N-linked glycosylation (GO:0006487)3.00025199
111negative regulation of B cell apoptotic process (GO:0002903)2.96454404
112negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.95003747
113lymphocyte homeostasis (GO:0002260)2.93557677
114ER-nucleus signaling pathway (GO:0006984)2.92798958
115positive regulation of Rho protein signal transduction (GO:0035025)2.90930277
116interferon-gamma-mediated signaling pathway (GO:0060333)2.90470276
117positive regulation of production of molecular mediator of immune response (GO:0002702)2.89416969
118nucleosome assembly (GO:0006334)2.85309952
119NIK/NF-kappaB signaling (GO:0038061)2.84142764
120germinal center formation (GO:0002467)2.81036256
121detection of bacterium (GO:0016045)2.74801290
122B cell mediated immunity (GO:0019724)2.72248273
123T cell migration (GO:0072678)2.71414491
124sex differentiation (GO:0007548)2.70061312
125positive regulation of pseudopodium assembly (GO:0031274)2.69151439
126regulation of alpha-beta T cell proliferation (GO:0046640)2.67252173
127thymic T cell selection (GO:0045061)2.66653542
128regulation of isotype switching to IgG isotypes (GO:0048302)2.65693719
129myeloid dendritic cell differentiation (GO:0043011)2.62727843
130dendritic cell chemotaxis (GO:0002407)2.59123864
131cellular response to interferon-gamma (GO:0071346)2.58737671
132detection of other organism (GO:0098543)2.56289829
133angiotensin maturation (GO:0002003)2.56244715
134positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.54374618
135positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50446422
136T cell costimulation (GO:0031295)2.47629684
137chaperone mediated protein folding requiring cofactor (GO:0051085)2.47568969
138keratinization (GO:0031424)2.47178171
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45297913
140lymphocyte costimulation (GO:0031294)2.43714838
141response to interferon-gamma (GO:0034341)2.43656839
142myeloid dendritic cell activation (GO:0001773)2.42332189
143regulation of pseudopodium assembly (GO:0031272)2.38032841
144negative regulation of viral release from host cell (GO:1902187)2.36115485
145regulation of inflammatory response to antigenic stimulus (GO:0002861)2.32445578
146midgut development (GO:0007494)2.30711247
147regulation of viral release from host cell (GO:1902186)2.30461166
148regulation of type I interferon-mediated signaling pathway (GO:0060338)2.29357065
149positive regulation of granulocyte chemotaxis (GO:0071624)2.28906304
150cytokine biosynthetic process (GO:0042089)2.26836830
151negative regulation of cell killing (GO:0031342)2.26708286
152negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26708286
153response to nitric oxide (GO:0071731)2.25620658
154regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.24833404
155protein-DNA complex assembly (GO:0065004)2.23878290
156regulation of interleukin-2 biosynthetic process (GO:0045076)2.23768189
157peptide catabolic process (GO:0043171)2.20649834
158T cell selection (GO:0045058)2.20031695
159protein-chromophore linkage (GO:0018298)2.16939878
160organ or tissue specific immune response (GO:0002251)2.15635776
161nucleosome organization (GO:0034728)2.15547926
162positive regulation of T cell migration (GO:2000406)2.15494240
163negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.12510086
164dendritic cell migration (GO:0036336)2.11686830
165antigen processing and presentation via MHC class Ib (GO:0002475)2.11343291
166lymphocyte migration (GO:0072676)2.10834308
167regulation of T cell migration (GO:2000404)2.10606832
168production of molecular mediator of immune response (GO:0002440)2.06427839
169positive regulation of lymphocyte migration (GO:2000403)2.06239210
170GDP-mannose metabolic process (GO:0019673)2.06186079
171* complement activation, classical pathway (GO:0006958)12.8816330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.40221815
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.41694797
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.06152674
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.61946019
5MYC_22102868_ChIP-Seq_BL_Human4.39849931
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.05893133
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.84177850
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.54543620
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.45708218
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44347191
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00366491
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.92308621
13VDR_21846776_ChIP-Seq_THP-1_Human2.89406109
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.86980959
15RUNX_20019798_ChIP-Seq_JUKART_Human2.68372947
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.65851512
17E2F7_22180533_ChIP-Seq_HELA_Human2.50054938
18MAF_26560356_Chip-Seq_TH1_Human2.49653149
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.40122585
20MYB_26560356_Chip-Seq_TH2_Human2.38572896
21MYB_26560356_Chip-Seq_TH1_Human2.36174007
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35622254
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30417034
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21696827
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16606003
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11147680
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07641704
28UTX_26944678_Chip-Seq_JUKART_Human2.01278907
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99840909
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99408377
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93129203
32SPI1_23547873_ChIP-Seq_NB4_Human1.92117436
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89965064
34VDR_24763502_ChIP-Seq_THP-1_Human1.89313471
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85912134
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83861872
37PU.1_20513432_ChIP-Seq_Bcells_Mouse1.82805804
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81276345
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73636610
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73080103
41TCF7_22412390_ChIP-Seq_EML_Mouse1.60430282
42SCL_19346495_ChIP-Seq_HPC-7_Human1.59143317
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58831694
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58355677
45GATA3_27048872_Chip-Seq_THYMUS_Human1.55695987
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53880070
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53435552
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.53040101
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50890418
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49518184
51MAF_26560356_Chip-Seq_TH2_Human1.47520746
52CIITA_25753668_ChIP-Seq_RAJI_Human1.46101342
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.42698009
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37307274
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37086510
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35998848
57KDM2B_26808549_Chip-Seq_DND41_Human1.35141820
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34929083
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32965452
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30900559
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28410252
62GATA3_26560356_Chip-Seq_TH2_Human1.27705678
63SPI1_23127762_ChIP-Seq_K562_Human1.24377669
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23556168
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20421682
66RACK7_27058665_Chip-Seq_MCF-7_Human1.20067390
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15786034
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15401558
69BCOR_27268052_Chip-Seq_Bcells_Human1.15047936
70KDM5A_27292631_Chip-Seq_BREAST_Human1.13775146
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13202930
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12456308
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.11767900
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11371616
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08674739
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.08053100
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06584060
78SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.05200333
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04278341
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04061008
81GATA1_22025678_ChIP-Seq_K562_Human1.02488359
82VDR_23849224_ChIP-Seq_CD4+_Human1.01331544
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00346302
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00147029
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99922908
86FOXP3_21729870_ChIP-Seq_TREG_Human0.99634443
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99434713
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99351913
89TFEB_21752829_ChIP-Seq_HELA_Human0.99064849
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98869073
91MYC_18555785_ChIP-Seq_MESCs_Mouse0.98436426
92GATA6_25053715_ChIP-Seq_YYC3_Human0.98414759
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96602264
94BCL6_27268052_Chip-Seq_Bcells_Human0.96365532
95CLOCK_20551151_ChIP-Seq_293T_Human0.96326255
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96233227
97NCOR1_26117541_ChIP-Seq_K562_Human0.95933506
98AR_21909140_ChIP-Seq_LNCAP_Human0.95636334
99RXR_22158963_ChIP-Seq_LIVER_Mouse0.94497279
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94154085
101FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93007349
102P300_27268052_Chip-Seq_Bcells_Human0.92794728
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92764512
104LXR_22292898_ChIP-Seq_THP-1_Human0.92625731
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91237368
106GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91155572
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90724224
108CTCF_26484167_Chip-Seq_Bcells_Mouse0.90456927
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90282836
110PU_27001747_Chip-Seq_BMDM_Mouse0.90026148
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89019444
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88036131
113STAT1_20625510_ChIP-Seq_HELA_Human0.87623770
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87187700
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86973918
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85672373
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85428797
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84589823
119FOXM1_23109430_ChIP-Seq_U2OS_Human0.84435864
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84153693
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83865408
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81104539
123GATA3_26560356_Chip-Seq_TH1_Human0.80866862
124IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80758028
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80509956
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79041397
127SPI1_20517297_ChIP-Seq_HL60_Human0.77717901
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77208813
129SMAD_19615063_ChIP-ChIP_OVARY_Human0.77106085
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.75742795
131RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75029408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.46670199
2MP0001800_abnormal_humoral_immune5.04255557
3MP0005387_immune_system_phenotype4.54219767
4MP0001790_abnormal_immune_system4.54219767
5MP0003303_peritoneal_inflammation4.22125487
6MP0002452_abnormal_antigen_presenting3.78670772
7MP0005671_abnormal_response_to3.69517968
8MP0002723_abnormal_immune_serum3.18882823
9MP0000685_abnormal_immune_system3.17656898
10MP0005000_abnormal_immune_tolerance3.07979934
11MP0002420_abnormal_adaptive_immunity3.06830051
12MP0001819_abnormal_immune_cell3.00060531
13MP0002398_abnormal_bone_marrow2.83458326
14MP0004264_abnormal_extraembryonic_tissu2.80225542
15MP0000716_abnormal_immune_system2.71193591
16MP0003724_increased_susceptibility_to2.68433068
17MP0010234_abnormal_vibrissa_follicle2.59285652
18MP0000689_abnormal_spleen_morphology2.56794939
19MP0005025_abnormal_response_to2.44214121
20MP0002166_altered_tumor_susceptibility2.29767123
21MP0001879_abnormal_lymphatic_vessel2.28320728
22MP0002429_abnormal_blood_cell2.24389366
23MP0002148_abnormal_hypersensitivity_rea2.23180213
24MP0003300_gastrointestinal_ulcer2.12522260
25MP0002722_abnormal_immune_system2.04530505
26MP0003763_abnormal_thymus_physiology2.01568945
27MP0002419_abnormal_innate_immunity2.00909720
28MP0003436_decreased_susceptibility_to2.00694602
29MP0009785_altered_susceptibility_to1.99240096
30MP0001348_abnormal_lacrimal_gland1.89062467
31MP0008438_abnormal_cutaneous_collagen1.87762774
32MP0002796_impaired_skin_barrier1.86605112
33MP0001845_abnormal_inflammatory_respons1.84793548
34MP0005275_abnormal_skin_tensile1.77951001
35MP0002138_abnormal_hepatobiliary_system1.76550674
36MP0010155_abnormal_intestine_physiology1.74637643
37MP0002006_tumorigenesis1.72451062
38MP0009333_abnormal_splenocyte_physiolog1.60369722
39MP0001853_heart_inflammation1.57857698
40MP0006054_spinal_hemorrhage1.57734171
41MP0002405_respiratory_system_inflammati1.57271786
42MP0004947_skin_inflammation1.53472669
43MP0005166_decreased_susceptibility_to1.47788705
44MP0005310_abnormal_salivary_gland1.47554867
45MP0002933_joint_inflammation1.46467854
46MP0004510_myositis1.42152945
47MP0005360_urolithiasis1.35756146
48MP0000703_abnormal_thymus_morphology1.35149405
49MP0003693_abnormal_embryo_hatching1.32823547
50MP0004782_abnormal_surfactant_physiolog1.32337813
51MP0001666_abnormal_nutrient_absorption1.22075942
52MP0002139_abnormal_hepatobiliary_system1.20473218
53MP0001873_stomach_inflammation1.20188601
54MP0002396_abnormal_hematopoietic_system1.20049266
55MP0003866_abnormal_defecation1.19592553
56MP0002019_abnormal_tumor_incidence1.19149137
57MP0000490_abnormal_crypts_of1.18777943
58MP0004043_abnormal_pH_regulation1.15322952
59MP0003183_abnormal_peptide_metabolism1.15110907
60MP0005381_digestive/alimentary_phenotyp1.12409810
61MP0005464_abnormal_platelet_physiology1.08834678
62MP0003806_abnormal_nucleotide_metabolis1.03820868
63MP0000465_gastrointestinal_hemorrhage1.02639952
64MP0002136_abnormal_kidney_physiology1.01712129
65MP0003868_abnormal_feces_composition1.00276491
66MP0006082_CNS_inflammation0.97245165
67MP0004808_abnormal_hematopoietic_stem0.95206956
68MP0008469_abnormal_protein_level0.91040847
69MP0003075_altered_response_to0.90866213
70MP0003195_calcinosis0.86522950
71MP0001851_eye_inflammation0.85639202
72MP0008004_abnormal_stomach_pH0.84506276
73MP0003453_abnormal_keratinocyte_physiol0.84471476
74MP0005085_abnormal_gallbladder_physiolo0.83725401
75MP0005501_abnormal_skin_physiology0.82767331
76MP0000343_altered_response_to0.82472138
77MP0005584_abnormal_enzyme/coenzyme_acti0.81857011
78MP0001545_abnormal_hematopoietic_system0.81494109
79MP0005397_hematopoietic_system_phenotyp0.81494109
80MP0002168_other_aberrant_phenotype0.79753573
81MP0002693_abnormal_pancreas_physiology0.78579084
82MP0001216_abnormal_epidermal_layer0.78423399
83MP0002060_abnormal_skin_morphology0.77896962
84MP0001191_abnormal_skin_condition0.76938821
85MP0003656_abnormal_erythrocyte_physiolo0.74951504
86MP0003448_altered_tumor_morphology0.74701155
87MP0001533_abnormal_skeleton_physiology0.73575630
88MP0005171_absent_coat_pigmentation0.72341732
89MP0004957_abnormal_blastocyst_morpholog0.72121639
90MP0005076_abnormal_cell_differentiation0.71845401
91MP0000003_abnormal_adipose_tissue0.71142414
92MP0004858_abnormal_nervous_system0.69612480
93MP0005165_increased_susceptibility_to0.69573459
94MP0003045_fibrosis0.69152343
95MP0001663_abnormal_digestive_system0.69090148
96MP0001664_abnormal_digestion0.67581492
97MP0010307_abnormal_tumor_latency0.67153414
98MP0000609_abnormal_liver_physiology0.66891791
99MP0008057_abnormal_DNA_replication0.66482679
100MP0003795_abnormal_bone_structure0.64335142
101MP0005503_abnormal_tendon_morphology0.63378456
102MP0003828_pulmonary_edema0.63090999
103MP0003943_abnormal_hepatobiliary_system0.63010571
104MP0003172_abnormal_lysosome_physiology0.61603320
105MP0005058_abnormal_lysosome_morphology0.61315651
106MP0005451_abnormal_body_composition0.61193472
107MP0003077_abnormal_cell_cycle0.60997031
108MP0010352_gastrointestinal_tract_polyps0.60430491
109MP0001919_abnormal_reproductive_system0.60246802
110MP0001944_abnormal_pancreas_morphology0.60204755
111MP0009764_decreased_sensitivity_to0.58324387
112MP0000858_altered_metastatic_potential0.58043850
113MP0005023_abnormal_wound_healing0.57922354
114MP0003191_abnormal_cellular_cholesterol0.56514096
115MP0000477_abnormal_intestine_morphology0.55921218
116MP0002083_premature_death0.55646376
117MP0002877_abnormal_melanocyte_morpholog0.54851797
118MP0009931_abnormal_skin_appearance0.51944087
119MP0005388_respiratory_system_phenotype0.48896396
120MP0002133_abnormal_respiratory_system0.48896396
121MP0009643_abnormal_urine_homeostasis0.48715126
122MP0000639_abnormal_adrenal_gland0.47421654
123MP0005621_abnormal_cell_physiology0.45759749
124MP0009840_abnormal_foam_cell0.45736357
125MP0000350_abnormal_cell_proliferation0.44895952
126MP0009763_increased_sensitivity_to0.43681486
127MP0003091_abnormal_cell_migration0.43600059
128MP0000733_abnormal_muscle_development0.43088634
129MP0002998_abnormal_bone_remodeling0.42213718
130MP0000313_abnormal_cell_death0.41559221
131MP0009278_abnormal_bone_marrow0.41317868
132MP0002909_abnormal_adrenal_gland0.39330218
133MP0008874_decreased_physiological_sensi0.37994433
134MP0003186_abnormal_redox_activity0.37143099
135MP0005174_abnormal_tail_pigmentation0.36625169

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)7.60027582
2Abnormality of B cell number (HP:0010975)7.60027582
3Colitis (HP:0002583)7.54545522
4Recurrent sinusitis (HP:0011108)7.47277349
5Recurrent bronchitis (HP:0002837)7.34911730
6Cellulitis (HP:0100658)6.83179680
7Gastrointestinal stroma tumor (HP:0100723)6.56990316
8Papilloma (HP:0012740)5.99954181
9Verrucae (HP:0200043)5.99954181
10IgM deficiency (HP:0002850)5.81438775
11Inflammation of the large intestine (HP:0002037)5.81154872
12Gastrointestinal inflammation (HP:0004386)5.51457367
13Recurrent viral infections (HP:0004429)5.36130141
14Recurrent pneumonia (HP:0006532)5.25508991
15Meningitis (HP:0001287)5.12979706
16Chronic sinusitis (HP:0011109)5.00836721
17Systemic lupus erythematosus (HP:0002725)4.69443704
18Chronic otitis media (HP:0000389)4.47488989
19Recurrent lower respiratory tract infections (HP:0002783)4.43899027
20Bronchitis (HP:0012387)4.37574389
21Emphysema (HP:0002097)4.30981607
22Osteomyelitis (HP:0002754)4.25036964
23Recurrent otitis media (HP:0000403)4.17785269
24Prostate neoplasm (HP:0100787)3.83654668
25Lymphopenia (HP:0001888)3.66575303
26Interstitial pulmonary disease (HP:0006530)3.64219623
27IgA deficiency (HP:0002720)3.60329748
28Malnutrition (HP:0004395)3.55049468
29Sepsis (HP:0100806)3.49195451
30Abnormality of cells of the lymphoid lineage (HP:0012140)3.48611814
31Skin rash (HP:0000988)3.48021658
32Vasculitis (HP:0002633)3.39332636
33Abnormality of small intestinal villus morphology (HP:0011472)3.34848512
34Villous atrophy (HP:0011473)3.34848512
35Elevated erythrocyte sedimentation rate (HP:0003565)3.32563829
36Hyperactive renin-angiotensin system (HP:0000841)3.24684541
37Restrictive lung disease (HP:0002091)3.23318595
38Recurrent abscess formation (HP:0002722)3.21588772
39Onycholysis (HP:0001806)3.19626930
40IgG deficiency (HP:0004315)3.07959424
41Abnormality of T cell physiology (HP:0011840)3.05275319
42Thyroiditis (HP:0100646)2.99734143
43Panhypogammaglobulinemia (HP:0003139)2.98779434
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.97989900
45Abnormality of the prostate (HP:0008775)2.96997515
46Abnormality of complement system (HP:0005339)2.88780716
47Dry hair (HP:0011359)2.85017225
48Recurrent bacterial skin infections (HP:0005406)2.84724033
49Basal cell carcinoma (HP:0002671)2.81025469
50Erythema (HP:0010783)2.80527645
51Decreased circulating renin level (HP:0003351)2.78934353
52Nasal polyposis (HP:0100582)2.76474455
53Autoimmune hemolytic anemia (HP:0001890)2.71217349
54Recurrent fungal infections (HP:0002841)2.64491298
55Myositis (HP:0100614)2.61970560
56Complement deficiency (HP:0004431)2.60528620
57Abnormality of glycolipid metabolism (HP:0010969)2.58923334
58Abnormality of liposaccharide metabolism (HP:0010968)2.58923334
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.58923334
60Leukopenia (HP:0001882)2.56121633
61Ankyloglossia (HP:0010296)2.55720218
62Alopecia of scalp (HP:0002293)2.55132411
63Abnormality of T cells (HP:0002843)2.54643429
64Glomerulonephritis (HP:0000099)2.49440766
65Mediastinal lymphadenopathy (HP:0100721)2.47504345
66Bronchiectasis (HP:0002110)2.47079380
67Small epiphyses (HP:0010585)2.46686956
68Plantar hyperkeratosis (HP:0007556)2.45998212
69Squamous cell carcinoma (HP:0002860)2.45517901
70Neutropenia (HP:0001875)2.44456986
71Thrombocytosis (HP:0001894)2.44335194
72Dysostosis multiplex (HP:0000943)2.44160528
73Urticaria (HP:0001025)2.43987968
74Palmoplantar hyperkeratosis (HP:0000972)2.42032836
75Eczematoid dermatitis (HP:0000976)2.40230206
76Recurrent skin infections (HP:0001581)2.35243522
77Mitral stenosis (HP:0001718)2.32130602
78Skin ulcer (HP:0200042)2.29125368
79Abnormality of the nasal mucosa (HP:0000433)2.29048954
80Oral leukoplakia (HP:0002745)2.28947148
81Conical tooth (HP:0000698)2.28112491
82Increased cerebral lipofuscin (HP:0011813)2.26593507
83Neonatal death (HP:0003811)2.20352188
84Palmar hyperkeratosis (HP:0010765)2.19284863
85Abnormal tarsal ossification (HP:0008369)2.18271998
86Pulmonary infiltrates (HP:0002113)2.16049353
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.15487419
88Gastrointestinal infarctions (HP:0005244)2.13092290
89Nephritis (HP:0000123)2.12673859
90Alkalosis (HP:0001948)2.11813181
91Recurrent gram-negative bacterial infections (HP:0005420)2.11021485
92Lymphoma (HP:0002665)2.10693991
93Vertebral compression fractures (HP:0002953)2.10689515
94Abnormality of glutamine family amino acid metabolism (HP:0010902)2.09502747
95Chronic mucocutaneous candidiasis (HP:0002728)2.08351131
96Recurrent cutaneous fungal infections (HP:0011370)2.08351131
97Abnormality of oral frenula (HP:0000190)2.07664611
98Abnormality of incisor morphology (HP:0011063)2.05220147
99Increased IgM level (HP:0003496)2.03770298
100Abnormality of macrophages (HP:0004311)2.01851075
101Premature loss of primary teeth (HP:0006323)2.01648338
102Osteolytic defects of the hand bones (HP:0009699)2.01502576
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.01502576
104Agammaglobulinemia (HP:0004432)10.3525761
105Obstructive lung disease (HP:0006536)1.99970664
106Chronic obstructive pulmonary disease (HP:0006510)1.99970664
107Increased IgE level (HP:0003212)1.95642369
108Pustule (HP:0200039)1.95443273
109Ileus (HP:0002595)1.93877699
110Right ventricular cardiomyopathy (HP:0011663)1.93174256
111Thick nail (HP:0001805)1.92397880
112Ridged nail (HP:0001807)1.91515001
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91375154
114Rhabdomyolysis (HP:0003201)1.91130880
115Viral hepatitis (HP:0006562)1.88373910
116Spontaneous hematomas (HP:0007420)1.87343747
117Arthralgia (HP:0002829)1.86203301
118Abnormality of T cell number (HP:0011839)1.85896533
119Myocardial infarction (HP:0001658)1.85763870
120Teleangiectasia of the skin (HP:0100585)1.84997114
121Annular pancreas (HP:0001734)1.84713699
122Encephalitis (HP:0002383)1.84038277
123Hypergammaglobulinemia (HP:0010702)1.83779151
124Dehydration (HP:0001944)1.83269562
125T lymphocytopenia (HP:0005403)1.80657449
126Autoimmune thrombocytopenia (HP:0001973)1.75554066
127Abnormality of the fingertips (HP:0001211)1.74301391
128Vacuolated lymphocytes (HP:0001922)1.71391201
129Flattened epiphyses (HP:0003071)1.66071083
130Microcytic anemia (HP:0001935)1.63874565
131External ear malformation (HP:0008572)1.61951231
132Stomatitis (HP:0010280)1.61124715
133Blepharitis (HP:0000498)1.61039318
134Fatigue (HP:0012378)1.60483634
135Chronic diarrhea (HP:0002028)1.58838872
136Petechiae (HP:0000967)1.54857126
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.51209773
138Retrobulbar optic neuritis (HP:0100654)1.48678064
139Optic neuritis (HP:0100653)1.48678064
140Irregular vertebral endplates (HP:0003301)1.38355218
141Acrocyanosis (HP:0001063)1.36670533
142Combined immunodeficiency (HP:0005387)1.34908939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.50087549
2MAP4K15.83585824
3PRPF4B4.85467359
4NME23.76864899
5SMG13.32093078
6CSF1R2.96531171
7GRK62.92228041
8MAP3K132.77605229
9SYK2.69350340
10TAF12.65988524
11TBK12.59544163
12MAP3K142.53797121
13TYK22.52880058
14RIPK42.47163784
15BLK2.36411796
16VRK22.32184934
17MAP3K102.26302519
18BTK2.11329273
19EIF2AK31.88035197
20IKBKE1.73814156
21IRAK31.69002359
22LYN1.67635838
23KIT1.67616175
24IRAK41.62657523
25MST1R1.57295514
26STK101.50503155
27SIK21.44327091
28MAP3K91.43997289
29TAOK31.43713329
30TAOK21.36687650
31IKBKB1.36205151
32JAK11.35586981
33LRRK21.34521453
34HCK1.33398123
35MAP3K11.26384757
36JAK31.24986145
37ARAF1.22112633
38MST41.15991996
39RIPK11.15631905
40TEC1.11792244
41EEF2K1.08665380
42ITK1.07189779
43BUB11.05167207
44STK241.01601998
45PRKCH0.97449832
46MAP2K30.96567440
47FES0.96161716
48NEK20.96079421
49IRAK10.95874041
50CSK0.95801420
51HIPK20.93881492
52LCK0.92775664
53PRKCQ0.92442506
54PIM10.91341537
55BRAF0.91053265
56MATK0.90271594
57KSR20.88241292
58GRK10.87638532
59SCYL20.87559808
60TGFBR20.86304401
61FRK0.82994896
62PDK20.82469190
63BCKDK0.79930543
64PDPK10.78454925
65NEK90.75779668
66NME10.74286611
67SIK30.73376898
68FGFR30.71598925
69CHUK0.70903529
70RPS6KA40.70790520
71ZAP700.69092763
72RAF10.68941628
73MAP3K20.68067543
74OXSR10.67323371
75SIK10.64927612
76NEK10.62493203
77MARK30.61498282
78MAP3K30.61233434
79MELK0.60714600
80CDK190.60499889
81PDK10.58086741
82BMPR20.54883484
83MAPKAPK50.51791807
84CLK10.51692658
85EPHB10.50145368
86PRKD20.49265935
87FGFR40.48929232
88ABL10.48928337
89MAPK70.47751568
90PIK3CG0.46103801
91MAP2K20.45854716
92ALK0.44575216
93TESK20.44485280
94FYN0.43235873
95CDK90.42544181
96MAP3K70.41402515
97PAK40.40796840
98MOS0.40260072
99IRAK20.40014919
100GRK50.39980540
101PKN20.39761436
102ACVR1B0.39686026
103PRKCD0.38967927
104PRKD10.38575551
105DAPK10.37727327
106MAPK120.37679367
107MAP3K80.37679112
108TXK0.37467791
109AKT20.37444402
110MAPKAPK30.36792841
111INSR0.36594823
112PRKCI0.36437283
113CDK120.34201557
114PRKG20.34186884
115FGR0.30885697
116PIK3CA0.30506183
117LMTK20.30391498
118MAPK110.30156850
119ICK0.29759999
120JAK20.28739814
121PKN10.28179295
122EIF2AK10.27014742
123TNK20.25208476
124EGFR0.24792671
125EIF2AK20.24301997
126CDK70.22967863
127MAPK40.22816992
128CDK40.21885504
129CCNB10.20570991
130CDC42BPA0.20294014
131MARK20.19917579
132CSNK1A1L0.19440104
133TRIB30.17891343
134CHEK20.16957221
135EPHA30.16392778
136KSR10.15946342
137MAPKAPK20.15438094
138BRD40.13668226
139MAPK30.13524678

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046726.75644067
2Primary immunodeficiency_Homo sapiens_hsa053405.98240038
3B cell receptor signaling pathway_Homo sapiens_hsa046625.23172398
4Protein export_Homo sapiens_hsa030604.48325738
5Graft-versus-host disease_Homo sapiens_hsa053323.73562178
6Type I diabetes mellitus_Homo sapiens_hsa049403.13257769
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.10507794
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.62949274
9Antigen processing and presentation_Homo sapiens_hsa046122.47763810
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.45254076
11N-Glycan biosynthesis_Homo sapiens_hsa005102.34032962
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09686375
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.87377339
14Leishmaniasis_Homo sapiens_hsa051401.84203159
15Hematopoietic cell lineage_Homo sapiens_hsa046401.81006914
16Osteoclast differentiation_Homo sapiens_hsa043801.78911449
17Rheumatoid arthritis_Homo sapiens_hsa053231.68071277
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60485558
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59319666
20T cell receptor signaling pathway_Homo sapiens_hsa046601.45130443
21Base excision repair_Homo sapiens_hsa034101.36761728
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36560534
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32229953
24Sulfur metabolism_Homo sapiens_hsa009201.30709293
25Other glycan degradation_Homo sapiens_hsa005111.29554690
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23815988
27Renin-angiotensin system_Homo sapiens_hsa046141.23292826
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21614376
29Measles_Homo sapiens_hsa051621.15584415
30Non-homologous end-joining_Homo sapiens_hsa034501.15579580
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15563169
32Tuberculosis_Homo sapiens_hsa051521.14589510
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13757993
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12647078
35Asthma_Homo sapiens_hsa053101.12419184
36Fructose and mannose metabolism_Homo sapiens_hsa000511.11906480
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.10368283
38Herpes simplex infection_Homo sapiens_hsa051681.07428053
39Chemokine signaling pathway_Homo sapiens_hsa040621.05594397
40Malaria_Homo sapiens_hsa051441.04389191
41Hepatitis B_Homo sapiens_hsa051611.03650340
42Phagosome_Homo sapiens_hsa041451.00276273
43Arginine biosynthesis_Homo sapiens_hsa002201.00060290
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97469522
45Systemic lupus erythematosus_Homo sapiens_hsa053220.95851482
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90577107
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89824578
48Epstein-Barr virus infection_Homo sapiens_hsa051690.86410492
49Toxoplasmosis_Homo sapiens_hsa051450.85008831
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84962526
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84762816
52Fat digestion and absorption_Homo sapiens_hsa049750.81987428
53Vitamin B6 metabolism_Homo sapiens_hsa007500.80376321
54Non-small cell lung cancer_Homo sapiens_hsa052230.78117930
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.77640954
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76639017
57Allograft rejection_Homo sapiens_hsa053300.76593437
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75536619
59HTLV-I infection_Homo sapiens_hsa051660.75414055
60Viral myocarditis_Homo sapiens_hsa054160.74816059
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.74111557
62DNA replication_Homo sapiens_hsa030300.73950885
63Pertussis_Homo sapiens_hsa051330.73175599
64Influenza A_Homo sapiens_hsa051640.72952816
65Apoptosis_Homo sapiens_hsa042100.72058910
66Legionellosis_Homo sapiens_hsa051340.71936217
67Prion diseases_Homo sapiens_hsa050200.68623339
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67639181
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66044747
70Shigellosis_Homo sapiens_hsa051310.64808013
71Pancreatic cancer_Homo sapiens_hsa052120.61018735
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60231497
73VEGF signaling pathway_Homo sapiens_hsa043700.60194851
74Ribosome_Homo sapiens_hsa030100.60042242
75Viral carcinogenesis_Homo sapiens_hsa052030.59454098
76Staphylococcus aureus infection_Homo sapiens_hsa051500.59342002
77Platelet activation_Homo sapiens_hsa046110.59234733
78Bladder cancer_Homo sapiens_hsa052190.58590040
79Acute myeloid leukemia_Homo sapiens_hsa052210.57267653
80Sulfur relay system_Homo sapiens_hsa041220.55948884
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53637789
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53483914
83TNF signaling pathway_Homo sapiens_hsa046680.51978756
84Folate biosynthesis_Homo sapiens_hsa007900.48836226
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48361755
86Long-term potentiation_Homo sapiens_hsa047200.47788904
87Galactose metabolism_Homo sapiens_hsa000520.47433625
88Chronic myeloid leukemia_Homo sapiens_hsa052200.47075998
89Carbon metabolism_Homo sapiens_hsa012000.45148820
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44583953
91Thyroid hormone synthesis_Homo sapiens_hsa049180.44561779
92Caffeine metabolism_Homo sapiens_hsa002320.43750812
93African trypanosomiasis_Homo sapiens_hsa051430.43748342
94Hepatitis C_Homo sapiens_hsa051600.43707610
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.42477204
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41783017
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41336755
98Phenylalanine metabolism_Homo sapiens_hsa003600.37806910
99Mineral absorption_Homo sapiens_hsa049780.37698392
100Biosynthesis of amino acids_Homo sapiens_hsa012300.37397230
101Autoimmune thyroid disease_Homo sapiens_hsa053200.35410331
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35297962
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34981440
104Mismatch repair_Homo sapiens_hsa034300.33024118
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31477065
106p53 signaling pathway_Homo sapiens_hsa041150.30637245
107Arachidonic acid metabolism_Homo sapiens_hsa005900.30277533
108Small cell lung cancer_Homo sapiens_hsa052220.29701241
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27942498
110Vibrio cholerae infection_Homo sapiens_hsa051100.26910744
111Prostate cancer_Homo sapiens_hsa052150.26748345
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25587036
113HIF-1 signaling pathway_Homo sapiens_hsa040660.25049161
114Insulin resistance_Homo sapiens_hsa049310.23737019
115Starch and sucrose metabolism_Homo sapiens_hsa005000.23489615
116MAPK signaling pathway_Homo sapiens_hsa040100.22816550
117Proteasome_Homo sapiens_hsa030500.22703886
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22502775
119Thyroid cancer_Homo sapiens_hsa052160.22234062
120Glioma_Homo sapiens_hsa052140.22058585
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21505889
122Lysosome_Homo sapiens_hsa041420.21355327
123MicroRNAs in cancer_Homo sapiens_hsa052060.20829469
124Complement and coagulation cascades_Homo sapiens_hsa046100.20782323
125Regulation of autophagy_Homo sapiens_hsa041400.20171847
126Pentose phosphate pathway_Homo sapiens_hsa000300.19998722
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19603331
128Pancreatic secretion_Homo sapiens_hsa049720.19286088
129Inositol phosphate metabolism_Homo sapiens_hsa005620.18984372
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18452722
131Homologous recombination_Homo sapiens_hsa034400.18069214
132Proteoglycans in cancer_Homo sapiens_hsa052050.14293580
133Renal cell carcinoma_Homo sapiens_hsa052110.13095313
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10642675
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.10161564
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08449514
137Histidine metabolism_Homo sapiens_hsa003400.07632845

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