IGLC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* complement activation (GO:0006956)9.98973023
2antigen processing and presentation of endogenous antigen (GO:0019883)8.92843071
3B cell receptor signaling pathway (GO:0050853)8.21940636
4positive regulation of respiratory burst (GO:0060267)8.11053403
5glomerular filtration (GO:0003094)6.87234256
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.81483507
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.81483507
8* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00026.59294798
9* Fc-gamma receptor signaling pathway (GO:0038094)6.59294798
10* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)6.59294798
11negative regulation of glucose import (GO:0046325)6.55807233
12* Fc receptor mediated stimulatory signaling pathway (GO:0002431)6.49917847
13* protein activation cascade (GO:0072376)6.32769804
14renal filtration (GO:0097205)6.21601023
15regulation of B cell receptor signaling pathway (GO:0050855)6.09098960
16* humoral immune response (GO:0006959)5.99377125
17negative regulation of B cell proliferation (GO:0030889)5.85595266
18cytidine deamination (GO:0009972)5.79163731
19cytidine metabolic process (GO:0046087)5.79163731
20cytidine catabolic process (GO:0006216)5.79163731
21signal peptide processing (GO:0006465)5.59231213
22retina homeostasis (GO:0001895)5.57214539
23cellular response to zinc ion (GO:0071294)5.50652553
24regulation of respiratory burst (GO:0060263)5.47699879
25regulation of B cell proliferation (GO:0030888)5.39645278
26negative regulation of glucose transport (GO:0010829)5.36684183
27regulation of B cell differentiation (GO:0045577)5.33698291
28positive regulation of B cell differentiation (GO:0045579)5.29007646
29regulation of glucose import in response to insulin stimulus (GO:2001273)5.04633828
30B cell proliferation (GO:0042100)4.98825857
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.98724730
32* immune response-activating cell surface receptor signaling pathway (GO:0002429)4.88004748
33positive regulation of gamma-delta T cell activation (GO:0046645)4.81015066
34regulation of cellular extravasation (GO:0002691)4.68428137
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.45928815
36regulation of antigen processing and presentation (GO:0002577)4.32435037
37detection of bacterium (GO:0016045)4.28800895
38mature B cell differentiation (GO:0002335)4.28657632
39pyrimidine ribonucleoside catabolic process (GO:0046133)4.27971036
40somatic diversification of immune receptors via somatic mutation (GO:0002566)4.25857852
41somatic hypermutation of immunoglobulin genes (GO:0016446)4.25857852
42positive regulation of immunoglobulin production (GO:0002639)4.16511359
43detection of other organism (GO:0098543)4.11607410
44regulation of interferon-beta biosynthetic process (GO:0045357)4.00826369
45regulation of B cell apoptotic process (GO:0002902)3.94293432
46regulation of B cell activation (GO:0050864)3.86578566
47regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.84343471
48angiotensin maturation (GO:0002003)3.80788263
49respiratory burst (GO:0045730)3.79937144
50negative regulation of cell killing (GO:0031342)3.74425736
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74425736
52antigen receptor-mediated signaling pathway (GO:0050851)3.69575903
53mature B cell differentiation involved in immune response (GO:0002313)3.67715592
54positive thymic T cell selection (GO:0045059)3.67438135
55B cell homeostasis (GO:0001782)3.67367746
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.65320547
57negative thymic T cell selection (GO:0045060)3.62869756
58positive regulation of Rap GTPase activity (GO:0032854)3.62393805
59positive regulation of pseudopodium assembly (GO:0031274)3.61713470
60regulation of gamma-delta T cell differentiation (GO:0045586)3.61163226
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.54707265
62regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.52104538
63cellular response to type I interferon (GO:0071357)3.49112293
64type I interferon signaling pathway (GO:0060337)3.49112293
65B cell activation (GO:0042113)3.48198850
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.47911098
67response to type I interferon (GO:0034340)3.47500635
68positive regulation of Cdc42 GTPase activity (GO:0043089)3.46282041
69positive regulation of B cell proliferation (GO:0030890)3.44141005
70* immune response-activating signal transduction (GO:0002757)3.43415321
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.39325981
72antimicrobial humoral response (GO:0019730)3.38242068
73negative regulation of B cell apoptotic process (GO:0002903)3.37477513
74B cell mediated immunity (GO:0019724)3.36270944
75regulation of interleukin-12 biosynthetic process (GO:0045075)3.35386543
76regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.33952401
77antibacterial humoral response (GO:0019731)3.32757662
78natural killer cell mediated immunity (GO:0002228)3.30130356
79natural killer cell mediated cytotoxicity (GO:0042267)3.30130356
80negative T cell selection (GO:0043383)3.29514721
81regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.27473097
82regulation of gamma-delta T cell activation (GO:0046643)3.22659111
83regulation of pseudopodium assembly (GO:0031272)3.21879344
84positive regulation of B cell activation (GO:0050871)3.20164223
85immunoglobulin mediated immune response (GO:0016064)3.18683150
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17634210
87cellular response to interferon-gamma (GO:0071346)3.16621741
88* immune response-regulating cell surface receptor signaling pathway (GO:0002768)3.16620698
89positive regulation of macrophage cytokine production (GO:0060907)3.13175427
90regulation of immunoglobulin production (GO:0002637)3.12699550
91thymic T cell selection (GO:0045061)3.11250792
92negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10938439
93chronic inflammatory response (GO:0002544)3.10743462
94germinal center formation (GO:0002467)3.09841548
95* activation of immune response (GO:0002253)3.09010819
96negative regulation of B cell activation (GO:0050869)3.08945926
97regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.07762836
98L-fucose catabolic process (GO:0042355)3.04694544
99fucose catabolic process (GO:0019317)3.04694544
100L-fucose metabolic process (GO:0042354)3.04694544
101defense response to protozoan (GO:0042832)3.04299948
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.02334375
103positive regulation by symbiont of host defense response (GO:0052509)2.99738789
104modulation by symbiont of host defense response (GO:0052031)2.99738789
105modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99738789
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99738789
107positive regulation by organism of defense response of other organism involved in symbiotic interact2.99738789
108modulation by symbiont of host immune response (GO:0052553)2.99738789
109response to interferon-gamma (GO:0034341)2.99095235
110detection of external biotic stimulus (GO:0098581)2.98898759
111regulation of Rap GTPase activity (GO:0032317)2.98879447
112dendritic cell chemotaxis (GO:0002407)2.98641684
113interferon-gamma-mediated signaling pathway (GO:0060333)2.98567262
114lymphocyte homeostasis (GO:0002260)2.97138098
115T cell selection (GO:0045058)2.94093369
116B cell activation involved in immune response (GO:0002312)2.93546407
117NIK/NF-kappaB signaling (GO:0038061)2.93271089
118peptide catabolic process (GO:0043171)2.89859108
119positive regulation of protein homooligomerization (GO:0032464)2.89005871
120chaperone mediated protein folding requiring cofactor (GO:0051085)2.88964559
121myeloid dendritic cell differentiation (GO:0043011)2.86423865
122positive regulation of production of molecular mediator of immune response (GO:0002702)2.84335943
123* Fc receptor signaling pathway (GO:0038093)2.83788136
124adhesion of symbiont to host cell (GO:0044650)2.83702697
125virion attachment to host cell (GO:0019062)2.83702697
126T-helper 1 type immune response (GO:0042088)2.83528975
127negative regulation of cellular response to insulin stimulus (GO:1900077)2.81247253
128* Fc-epsilon receptor signaling pathway (GO:0038095)2.81057009
129surfactant homeostasis (GO:0043129)2.80245840
130macrophage activation involved in immune response (GO:0002281)2.80183491
131eosinophil chemotaxis (GO:0048245)2.79527894
132positive regulation of T cell migration (GO:2000406)2.79500062
133response to interleukin-15 (GO:0070672)2.79355336
134regulation of alpha-beta T cell proliferation (GO:0046640)2.78735450
135regulation of integrin activation (GO:0033623)2.78710216
136positive regulation of antigen processing and presentation (GO:0002579)2.78140703
137T cell costimulation (GO:0031295)2.78083550
138positive regulation of gene expression, epigenetic (GO:0045815)2.77323877
139phenylpropanoid metabolic process (GO:0009698)2.76799320
140lymphocyte proliferation (GO:0046651)2.75275336
141positive regulation of granulocyte chemotaxis (GO:0071624)2.74709216
142production of molecular mediator of immune response (GO:0002440)2.74185010
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73883832
144lymphocyte costimulation (GO:0031294)2.73877727
145maintenance of gastrointestinal epithelium (GO:0030277)2.73047333
146I-kappaB phosphorylation (GO:0007252)2.72556128
147regulation of T cell migration (GO:2000404)2.69735804
148antigen processing and presentation via MHC class Ib (GO:0002475)2.67162486
149regulation of T cell tolerance induction (GO:0002664)2.65126783
150myeloid dendritic cell activation (GO:0001773)2.63732318
151regulation of guanylate cyclase activity (GO:0031282)2.62844354
152positive regulation of neutrophil migration (GO:1902624)2.60026787
153positive regulation of neutrophil chemotaxis (GO:0090023)2.60026787
154intestinal absorption (GO:0050892)2.58285341
155eosinophil migration (GO:0072677)2.56695261
156GDP-mannose metabolic process (GO:0019673)2.51957422
157positive regulation of lymphocyte migration (GO:2000403)2.51659686
158production of molecular mediator involved in inflammatory response (GO:0002532)2.51397921
159detection of biotic stimulus (GO:0009595)2.51302398
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50682807
161defense response to Gram-negative bacterium (GO:0050829)2.45750902
162dendritic cell migration (GO:0036336)2.45335643
163regulation of T-helper 1 cell differentiation (GO:0045625)2.44995655
164adhesion of symbiont to host (GO:0044406)2.41514509
165protein-chromophore linkage (GO:0018298)2.40177442
166interferon-gamma secretion (GO:0072643)2.40054298
167response to nitric oxide (GO:0071731)2.39053727
168* complement activation, classical pathway (GO:0006958)13.2088654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.86516949
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.24402978
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.13443140
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.07724976
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.50829712
6MYC_22102868_ChIP-Seq_BL_Human4.44018448
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.28264985
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.74884283
9E2F7_22180533_ChIP-Seq_HELA_Human3.59715910
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.39488643
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24493846
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08368495
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89849578
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84642634
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.80643600
16VDR_21846776_ChIP-Seq_THP-1_Human2.79444242
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.55887765
18RUNX_20019798_ChIP-Seq_JUKART_Human2.47316644
19MAF_26560356_Chip-Seq_TH1_Human2.43968871
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42146029
21MYB_26560356_Chip-Seq_TH1_Human2.31463012
22MYB_26560356_Chip-Seq_TH2_Human2.30905366
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26995477
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22783642
25CDX2_20551321_ChIP-Seq_CACO-2_Human2.12581210
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09794550
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04795021
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99864703
29UTX_26944678_Chip-Seq_JUKART_Human1.97134608
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95507575
31SPI1_23547873_ChIP-Seq_NB4_Human1.93638689
32VDR_24763502_ChIP-Seq_THP-1_Human1.90853542
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88347056
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.86725473
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82305382
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81977380
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80629296
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79430122
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75253473
40PU.1_20513432_ChIP-Seq_Bcells_Mouse1.74675771
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74032453
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73213570
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68665640
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.65029507
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64514898
46CIITA_25753668_ChIP-Seq_RAJI_Human1.61812504
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58472646
48SCL_19346495_ChIP-Seq_HPC-7_Human1.57522774
49CLOCK_20551151_ChIP-Seq_293T_Human1.56109105
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54856071
51GATA3_27048872_Chip-Seq_THYMUS_Human1.52605097
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50798307
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50463819
54TCF7_22412390_ChIP-Seq_EML_Mouse1.48654318
55MAF_26560356_Chip-Seq_TH2_Human1.48265247
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.47802878
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.47426777
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46692442
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44705669
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42547685
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41623813
62EGR1_19032775_ChIP-ChIP_M12_Human1.38445279
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38080625
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36824008
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36594615
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36554710
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36112532
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35673503
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34717640
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34174817
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33930280
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33692121
73RACK7_27058665_Chip-Seq_MCF-7_Human1.33240086
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30398952
75SOX2_20726797_ChIP-Seq_SW620_Human1.28345845
76SPI1_23127762_ChIP-Seq_K562_Human1.26732742
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.26724236
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.26251554
79GATA3_26560356_Chip-Seq_TH2_Human1.25127870
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24080608
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20343379
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.19267431
83KDM2B_26808549_Chip-Seq_DND41_Human1.18965916
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18112854
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17166312
86GATA6_25053715_ChIP-Seq_YYC3_Human1.16400578
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16019386
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15541869
89VDR_23849224_ChIP-Seq_CD4+_Human1.15032057
90FOXP3_21729870_ChIP-Seq_TREG_Human1.14673632
91BCOR_27268052_Chip-Seq_Bcells_Human1.14126175
92GATA4_25053715_ChIP-Seq_YYC3_Human1.13481419
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12394132
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12009234
95KDM5A_27292631_Chip-Seq_BREAST_Human1.10589826
96GATA1_19941826_ChIP-Seq_K562_Human1.09111338
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08745826
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.08152516
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07845784
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.06572355
101GATA1_22025678_ChIP-Seq_K562_Human1.06508246
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06332230
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05786661
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05093399
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04561767
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03308152
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.03141433
108EST1_17652178_ChIP-ChIP_JURKAT_Human1.01103701
109E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01063064
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00814143
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99586548
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99029597
113GABP_17652178_ChIP-ChIP_JURKAT_Human0.99005561
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96911947
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96902149
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96673786
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.96561131
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.95694797
119VDR_24787735_ChIP-Seq_THP-1_Human0.95662768
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95262410
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94837197
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94505045
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94483643
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.93377335
125BCL6_27268052_Chip-Seq_Bcells_Human0.93351488
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92409100
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90581751
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90108848
129P300_27268052_Chip-Seq_Bcells_Human0.90004993
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88421538
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88346922
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87701292
133FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86796130
134PU_27001747_Chip-Seq_BMDM_Mouse0.85963443
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84720026
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84480473
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84469511
138LXR_22292898_ChIP-Seq_THP-1_Human0.83038016
139GATA3_26560356_Chip-Seq_TH1_Human0.82867725
140KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82653966
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82520444
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.81267930
143STAT1_20625510_ChIP-Seq_HELA_Human0.81091413
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79028104
145CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78887396
146CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78040576
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76285412
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75736697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.57171560
2MP0001800_abnormal_humoral_immune5.20862644
3MP0001790_abnormal_immune_system4.64323185
4MP0005387_immune_system_phenotype4.64323185
5MP0003724_increased_susceptibility_to4.08912325
6MP0002452_abnormal_antigen_presenting3.88118625
7MP0003303_peritoneal_inflammation3.87542748
8MP0005671_abnormal_response_to3.71370236
9MP0000685_abnormal_immune_system3.53520483
10MP0002723_abnormal_immune_serum3.25345117
11MP0002420_abnormal_adaptive_immunity3.16537117
12MP0005000_abnormal_immune_tolerance3.10657278
13MP0001819_abnormal_immune_cell3.08378444
14MP0002398_abnormal_bone_marrow2.93729005
15MP0000716_abnormal_immune_system2.77965188
16MP0000689_abnormal_spleen_morphology2.62563895
17MP0002138_abnormal_hepatobiliary_system2.49953934
18MP0005025_abnormal_response_to2.34716167
19MP0002148_abnormal_hypersensitivity_rea2.32149755
20MP0002166_altered_tumor_susceptibility2.31837332
21MP0002429_abnormal_blood_cell2.30197095
22MP0003763_abnormal_thymus_physiology2.21491164
23MP0010234_abnormal_vibrissa_follicle2.20104348
24MP0002722_abnormal_immune_system2.13394535
25MP0005166_decreased_susceptibility_to2.01831600
26MP0002419_abnormal_innate_immunity1.96356551
27MP0003300_gastrointestinal_ulcer1.95674359
28MP0005360_urolithiasis1.91244119
29MP0004782_abnormal_surfactant_physiolog1.90219248
30MP0009785_altered_susceptibility_to1.89362315
31MP0004264_abnormal_extraembryonic_tissu1.87600195
32MP0001879_abnormal_lymphatic_vessel1.86619454
33MP0005275_abnormal_skin_tensile1.86429583
34MP0006054_spinal_hemorrhage1.82588111
35MP0001845_abnormal_inflammatory_respons1.81371197
36MP0002139_abnormal_hepatobiliary_system1.77684708
37MP0002006_tumorigenesis1.74787973
38MP0004858_abnormal_nervous_system1.70819289
39MP0003436_decreased_susceptibility_to1.70429003
40MP0005310_abnormal_salivary_gland1.69772520
41MP0004947_skin_inflammation1.69236739
42MP0010155_abnormal_intestine_physiology1.64445546
43MP0002405_respiratory_system_inflammati1.61677013
44MP0009840_abnormal_foam_cell1.55478262
45MP0003693_abnormal_embryo_hatching1.55015605
46MP0002796_impaired_skin_barrier1.53584614
47MP0004510_myositis1.52803209
48MP0009333_abnormal_splenocyte_physiolog1.52635750
49MP0003191_abnormal_cellular_cholesterol1.50917481
50MP0002933_joint_inflammation1.45932396
51MP0001666_abnormal_nutrient_absorption1.44125090
52MP0001853_heart_inflammation1.43863666
53MP0001873_stomach_inflammation1.41899108
54MP0000703_abnormal_thymus_morphology1.39257272
55MP0008438_abnormal_cutaneous_collagen1.35264107
56MP0003866_abnormal_defecation1.33357035
57MP0002396_abnormal_hematopoietic_system1.25787581
58MP0002019_abnormal_tumor_incidence1.25417760
59MP0003448_altered_tumor_morphology1.25173663
60MP0008004_abnormal_stomach_pH1.24433933
61MP0003075_altered_response_to1.23141862
62MP0000490_abnormal_crypts_of1.12060263
63MP0005085_abnormal_gallbladder_physiolo1.11879655
64MP0000604_amyloidosis1.09967174
65MP0005464_abnormal_platelet_physiology1.07815391
66MP0000465_gastrointestinal_hemorrhage1.06618176
67MP0002136_abnormal_kidney_physiology1.04306776
68MP0000343_altered_response_to1.04285694
69MP0006082_CNS_inflammation1.04086730
70MP0002998_abnormal_bone_remodeling1.01771943
71MP0005409_darkened_coat_color1.00710357
72MP0003183_abnormal_peptide_metabolism0.99574030
73MP0003453_abnormal_keratinocyte_physiol0.98922709
74MP0010094_abnormal_chromosome_stability0.97863835
75MP0005503_abnormal_tendon_morphology0.97106287
76MP0001664_abnormal_digestion0.97045038
77MP0008057_abnormal_DNA_replication0.94871562
78MP0005390_skeleton_phenotype0.91115634
79MP0001851_eye_inflammation0.90966295
80MP0000249_abnormal_blood_vessel0.90868752
81MP0009278_abnormal_bone_marrow0.89927479
82MP0008469_abnormal_protein_level0.89004417
83MP0004808_abnormal_hematopoietic_stem0.88893935
84MP0003329_amyloid_beta_deposits0.87856389
85MP0008260_abnormal_autophagy0.87404249
86MP0003077_abnormal_cell_cycle0.86401914
87MP0004019_abnormal_vitamin_homeostasis0.86242537
88MP0009379_abnormal_foot_pigmentation0.86164362
89MP0003279_aneurysm0.84022110
90MP0001958_emphysema0.82699811
91MP0010352_gastrointestinal_tract_polyps0.82148058
92MP0005365_abnormal_bile_salt0.81839321
93MP0002277_abnormal_respiratory_mucosa0.81187628
94MP0005164_abnormal_response_to0.80420308
95MP0000003_abnormal_adipose_tissue0.78894311
96MP0001216_abnormal_epidermal_layer0.78602753
97MP0005584_abnormal_enzyme/coenzyme_acti0.76956792
98MP0005165_increased_susceptibility_to0.75930835
99MP0003806_abnormal_nucleotide_metabolis0.74479904
100MP0001663_abnormal_digestive_system0.73476414
101MP0004957_abnormal_blastocyst_morpholog0.72553677
102MP0003045_fibrosis0.72155850
103MP0000678_abnormal_parathyroid_gland0.72065134
104MP0003868_abnormal_feces_composition0.71324557
105MP0002133_abnormal_respiratory_system0.70437674
106MP0002693_abnormal_pancreas_physiology0.70010942
107MP0001191_abnormal_skin_condition0.69954971
108MP0005451_abnormal_body_composition0.66405663
109MP0003656_abnormal_erythrocyte_physiolo0.62164063
110MP0005397_hematopoietic_system_phenotyp0.61491635
111MP0001545_abnormal_hematopoietic_system0.61491635
112MP0000609_abnormal_liver_physiology0.61302019
113MP0002083_premature_death0.59985771
114MP0002168_other_aberrant_phenotype0.59747000
115MP0005023_abnormal_wound_healing0.54338973
116MP0005076_abnormal_cell_differentiation0.53989495
117MP0009643_abnormal_urine_homeostasis0.53597511
118MP0002876_abnormal_thyroid_physiology0.53595388
119MP0001533_abnormal_skeleton_physiology0.53508314
120MP0001919_abnormal_reproductive_system0.52638702
121MP0000477_abnormal_intestine_morphology0.51739787
122MP0000350_abnormal_cell_proliferation0.50436941
123MP0005058_abnormal_lysosome_morphology0.48857738
124MP0000013_abnormal_adipose_tissue0.48797624
125MP0009764_decreased_sensitivity_to0.48612233
126MP0000313_abnormal_cell_death0.48610919
127MP0001944_abnormal_pancreas_morphology0.46596815
128MP0009763_increased_sensitivity_to0.45711711
129MP0001730_embryonic_growth_arrest0.44909278
130MP0009931_abnormal_skin_appearance0.44624744
131MP0005621_abnormal_cell_physiology0.44420904
132MP0003195_calcinosis0.42906817
133MP0003828_pulmonary_edema0.40910411
134MP0002169_no_abnormal_phenotype0.39810764
135MP0002873_normal_phenotype0.39531830
136MP0008874_decreased_physiological_sensi0.39388313
137MP0003091_abnormal_cell_migration0.38765459
138MP0000858_altered_metastatic_potential0.38596960
139MP0000639_abnormal_adrenal_gland0.37512010
140MP0002909_abnormal_adrenal_gland0.36463878
141MP0002135_abnormal_kidney_morphology0.35427457
142MP0005381_digestive/alimentary_phenotyp0.35316127
143MP0003943_abnormal_hepatobiliary_system0.35281452

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)7.76098517
2Recurrent sinusitis (HP:0011108)7.58005093
3Gastrointestinal stroma tumor (HP:0100723)7.46089919
4Abnormality of B cell number (HP:0010975)7.04640812
5B lymphocytopenia (HP:0010976)7.04640812
6Colitis (HP:0002583)6.96615396
7Cellulitis (HP:0100658)6.91818473
8Systemic lupus erythematosus (HP:0002725)6.33001565
9Papilloma (HP:0012740)6.14523030
10Verrucae (HP:0200043)6.14523030
11IgM deficiency (HP:0002850)5.86446328
12Recurrent pneumonia (HP:0006532)5.42040136
13Inflammation of the large intestine (HP:0002037)5.32254269
14Recurrent viral infections (HP:0004429)5.30970386
15Chronic sinusitis (HP:0011109)5.28389264
16Meningitis (HP:0001287)5.20678978
17Malnutrition (HP:0004395)5.09761547
18Gastrointestinal inflammation (HP:0004386)5.07591127
19Recurrent lower respiratory tract infections (HP:0002783)4.80406763
20Emphysema (HP:0002097)4.59973423
21Bronchitis (HP:0012387)4.59849710
22Osteomyelitis (HP:0002754)4.35163923
23Chronic otitis media (HP:0000389)4.33124044
24Recurrent otitis media (HP:0000403)4.29064622
25Prostate neoplasm (HP:0100787)4.23955279
26Lymphopenia (HP:0001888)4.17102716
27IgA deficiency (HP:0002720)4.16092446
28Abnormality of cells of the lymphoid lineage (HP:0012140)4.02189019
29Abnormality of complement system (HP:0005339)3.96295077
30IgG deficiency (HP:0004315)3.78724126
31Vasculitis (HP:0002633)3.74402877
32Glomerulonephritis (HP:0000099)3.74119379
33Complement deficiency (HP:0004431)3.66469984
34Panhypogammaglobulinemia (HP:0003139)3.64467166
35Sepsis (HP:0100806)3.61346404
36Thyroiditis (HP:0100646)3.50607113
37Restrictive lung disease (HP:0002091)3.50026899
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.44320697
39Skin rash (HP:0000988)3.33067176
40Abnormality of the prostate (HP:0008775)3.32510358
41Interstitial pulmonary disease (HP:0006530)3.28111845
42Abnormality of T cell physiology (HP:0011840)3.25672294
43Recurrent abscess formation (HP:0002722)3.21633754
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13984640
45Nephritis (HP:0000123)3.07698576
46Premature loss of primary teeth (HP:0006323)3.06048783
47Recurrent bacterial skin infections (HP:0005406)3.00259325
48Elevated erythrocyte sedimentation rate (HP:0003565)2.96161136
49Spontaneous hematomas (HP:0007420)2.93774307
50Recurrent fungal infections (HP:0002841)2.92101941
51Abnormality of T cells (HP:0002843)2.83099595
52Gastrointestinal infarctions (HP:0005244)2.78692246
53Leukopenia (HP:0001882)2.73165399
54Gingivitis (HP:0000230)2.72343502
55Alopecia of scalp (HP:0002293)2.63172092
56Recurrent skin infections (HP:0001581)2.55610752
57Neutropenia (HP:0001875)2.53112820
58Nasal polyposis (HP:0100582)2.51933382
59Small epiphyses (HP:0010585)2.50611842
60Mediastinal lymphadenopathy (HP:0100721)2.49989268
61Orchitis (HP:0100796)2.47548871
62Autoimmune thrombocytopenia (HP:0001973)2.47064558
63Lymphoma (HP:0002665)2.44986623
64Recurrent cutaneous fungal infections (HP:0011370)2.43846521
65Chronic mucocutaneous candidiasis (HP:0002728)2.43846521
66Hemoptysis (HP:0002105)2.41988678
67Leukocytosis (HP:0001974)2.41555766
68Thrombocytosis (HP:0001894)2.39008228
69Hyperactive renin-angiotensin system (HP:0000841)2.38657927
70Eczematoid dermatitis (HP:0000976)2.37237793
71Abnormality of T cell number (HP:0011839)2.35677664
72Myositis (HP:0100614)2.35455194
73Skin ulcer (HP:0200042)2.35445835
74Mitral stenosis (HP:0001718)2.34625219
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30933985
76Pulmonary infiltrates (HP:0002113)2.25104350
77Bronchiectasis (HP:0002110)2.22612906
78T lymphocytopenia (HP:0005403)2.20736754
79Basal cell carcinoma (HP:0002671)2.16347108
80Erythema (HP:0010783)2.15484613
81Right ventricular cardiomyopathy (HP:0011663)2.15186347
82Purpura (HP:0000979)2.10682385
83Ileus (HP:0002595)2.10143875
84Abnormality of the nasal mucosa (HP:0000433)2.09578569
85Viral hepatitis (HP:0006562)2.07693504
86Hemorrhage of the eye (HP:0011885)2.06707733
87Chest pain (HP:0100749)2.01806605
88Arthralgia (HP:0002829)2.00476189
89Recurrent gram-negative bacterial infections (HP:0005420)2.00228783
90Polycythemia (HP:0001901)2.00184418
91Agammaglobulinemia (HP:0004432)10.7239896
92Combined immunodeficiency (HP:0005387)1.98917894
93Urticaria (HP:0001025)1.97612981
94Decreased circulating renin level (HP:0003351)1.94946719
95Retrobulbar optic neuritis (HP:0100654)1.93684404
96Optic neuritis (HP:0100653)1.93684404
97Abnormal hair laboratory examination (HP:0003328)1.93207752
98Pustule (HP:0200039)1.92988737
99Hypermelanotic macule (HP:0001034)1.92273500
100Encephalitis (HP:0002383)1.91818134
101Dehydration (HP:0001944)1.90528548
102Segmental peripheral demyelination/remyelination (HP:0003481)1.89786897
103Ankyloglossia (HP:0010296)1.89522840
104Abnormality of male internal genitalia (HP:0000022)1.89332641
105Obstructive lung disease (HP:0006536)1.89024178
106Chronic obstructive pulmonary disease (HP:0006510)1.89024178
107Palmoplantar hyperkeratosis (HP:0000972)1.85861245
108Abnormality of the pleura (HP:0002103)1.85393381
109Alkalosis (HP:0001948)1.85128970
110Neoplasm of the lung (HP:0100526)1.82424204
111Squamous cell carcinoma (HP:0002860)1.82311395
112Abnormality of the fingertips (HP:0001211)1.81050019
113Increased IgM level (HP:0003496)1.80979125
114Keratoconjunctivitis sicca (HP:0001097)1.80192403
115Increased IgE level (HP:0003212)1.78393111
116Plantar hyperkeratosis (HP:0007556)1.77896153
117Hypergammaglobulinemia (HP:0010702)1.73833813
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73682940
119Chronic diarrhea (HP:0002028)1.72469984
120Severe combined immunodeficiency (HP:0004430)1.72188767
121Abnormality of macrophages (HP:0004311)1.71615664
122Teleangiectasia of the skin (HP:0100585)1.69245503
123Xerostomia (HP:0000217)1.68569672
124Onycholysis (HP:0001806)1.65619072
125Flattened epiphyses (HP:0003071)1.58550503
126Eosinophilia (HP:0001880)1.56957763
127Hypertensive crisis (HP:0100735)1.56515955
128External ear malformation (HP:0008572)1.55522785
129Acrocyanosis (HP:0001063)1.55286560
130Petechiae (HP:0000967)1.51256923
131Abnormality of small intestinal villus morphology (HP:0011472)1.49957357
132Villous atrophy (HP:0011473)1.49957357
133Vacuolated lymphocytes (HP:0001922)1.49138489
134Microcytic anemia (HP:0001935)1.47000728
135Myocardial infarction (HP:0001658)1.46424931
136Hypoplasia of the thymus (HP:0000778)1.44347479
137Irregular vertebral endplates (HP:0003301)1.40987658
138Stomatitis (HP:0010280)1.40821365
139Mucosal telangiectasiae (HP:0100579)1.39331010
140Fatigue (HP:0012378)1.35697812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.48063133
2ERN15.87396947
3MST1R3.12601072
4CSF1R3.05768575
5GRK63.04160635
6SYK3.00437892
7NME22.77950694
8PRPF4B2.77947461
9MAP3K132.74050371
10BLK2.73099703
11MAP3K102.42126411
12MAP3K142.41372595
13RIPK42.38801802
14RIPK12.35822387
15TBK12.31395778
16BTK2.27120112
17EPHA32.18840177
18TYK22.17783449
19KIT2.02559312
20LYN1.93526464
21EPHB11.88801018
22EIF2AK31.78508010
23STK101.69973180
24IRAK41.56734927
25IRAK31.56099453
26LRRK21.51993521
27SIK21.47150775
28MST41.44649064
29MAP3K11.43909206
30IKBKE1.43622921
31PRKCH1.34061274
32JAK11.32120245
33HCK1.29974496
34NEK21.28426625
35ACVR1B1.25630758
36TAOK31.25139576
37IKBKB1.21961012
38PIK3CA1.21649612
39ITK1.21581032
40PRKCQ1.20674556
41SMG11.18925206
42EPHA21.16149973
43PRKG21.13660370
44TEC1.12284874
45TXK1.11819480
46JAK31.11581527
47MAP3K91.11362826
48PTK61.02023046
49IRAK11.01236845
50ARAF1.01084728
51FES1.00988337
52LCK1.00861682
53MATK1.00376479
54EEF2K0.99560334
55CSK0.98797933
56PIM10.95244934
57PDGFRA0.93115063
58GRK10.93008986
59MAP3K30.92314591
60MET0.90021169
61EIF2AK10.86906074
62FER0.86160801
63PRKCI0.85666432
64DDR20.85125648
65TESK20.84688485
66PKN20.81906181
67TAOK10.81489969
68STK240.80646512
69SIK30.79491346
70CLK10.77530398
71FGFR30.75827149
72MAP3K110.75528287
73HIPK20.74725401
74RPS6KA40.74348081
75NEK90.72595846
76PDPK10.72193850
77MARK30.71624728
78ZAP700.70758466
79EPHB20.70691415
80MAP2K20.69989704
81NLK0.69583957
82FRK0.69571830
83TGFBR20.67604036
84BUB10.67598229
85CHUK0.65786548
86BCKDK0.62474081
87SIK10.60682114
88YES10.60078920
89CCNB10.58363550
90RET0.56639828
91FGFR40.54943705
92MAP3K20.54770540
93FYN0.51624305
94MYLK0.48963364
95PRKCD0.48360096
96PRKD20.47483124
97KSR20.47139605
98TESK10.46432678
99ABL10.46053801
100DMPK0.46023848
101KDR0.45651411
102CDK60.44718837
103MAPK120.44507823
104MAP3K60.43461830
105PDK10.43456784
106MAPK70.43298663
107TGFBR10.42238200
108CDK90.41372349
109INSR0.40877992
110LMTK20.40839569
111ALK0.40790118
112MAP3K80.40768884
113CDC42BPA0.40676239
114RAF10.40528751
115PRKD10.39670510
116BMPR20.39564211
117MAP2K30.39440718
118PAK40.38409799
119MAP3K120.37106880
120PIK3CG0.36906136
121MAP2K10.36267287
122CDK120.35812098
123TAOK20.35232538
124MAPK110.34847160
125BMX0.33840796
126MAP3K70.33238049
127CSNK1A1L0.33233821
128PDK20.33190753
129SRC0.33149383
130CDK40.33099296
131CSNK1G30.31728375
132MAP2K60.31093599
133OXSR10.30528235
134MELK0.28941870
135MOS0.26603004
136PKN10.25606794
137CSNK1G10.24769340
138TLK10.24195858
139FGR0.23617165
140CHEK20.21135139
141MAPK40.20841395
142EGFR0.19930430
143MAPKAPK20.19890339
144JAK20.17502153
145TRIB30.16013049
146TNK20.15405282
147CSNK1G20.14456535
148CHEK10.14028691

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.88131034
2Intestinal immune network for IgA production_Homo sapiens_hsa046726.69786314
3B cell receptor signaling pathway_Homo sapiens_hsa046625.47894988
4Protein export_Homo sapiens_hsa030603.57317347
5Type I diabetes mellitus_Homo sapiens_hsa049402.79055467
6Antigen processing and presentation_Homo sapiens_hsa046122.59181937
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.47743430
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.47200143
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.28965038
10Base excision repair_Homo sapiens_hsa034102.08514359
11Hematopoietic cell lineage_Homo sapiens_hsa046401.91626574
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88128232
13N-Glycan biosynthesis_Homo sapiens_hsa005101.86612180
14Non-homologous end-joining_Homo sapiens_hsa034501.74422153
15Leishmaniasis_Homo sapiens_hsa051401.71559982
16DNA replication_Homo sapiens_hsa030301.68559875
17Osteoclast differentiation_Homo sapiens_hsa043801.68269476
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61144262
19Fat digestion and absorption_Homo sapiens_hsa049751.58197453
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48438248
21Rheumatoid arthritis_Homo sapiens_hsa053231.45075031
22Renin-angiotensin system_Homo sapiens_hsa046141.43667013
23T cell receptor signaling pathway_Homo sapiens_hsa046601.42224244
24Arginine biosynthesis_Homo sapiens_hsa002201.38432130
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36438303
26Mismatch repair_Homo sapiens_hsa034301.34828237
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33972536
28Fructose and mannose metabolism_Homo sapiens_hsa000511.33650827
29Sulfur metabolism_Homo sapiens_hsa009201.20857114
30Tuberculosis_Homo sapiens_hsa051521.15651100
31Asthma_Homo sapiens_hsa053101.14919594
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13995096
33Other glycan degradation_Homo sapiens_hsa005111.10598350
34Phagosome_Homo sapiens_hsa041451.09025442
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07500646
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07072115
37Herpes simplex infection_Homo sapiens_hsa051681.05051814
38Measles_Homo sapiens_hsa051621.04971225
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03142251
40Ribosome_Homo sapiens_hsa030101.03080565
41Complement and coagulation cascades_Homo sapiens_hsa046101.02866923
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.02728636
43Chemokine signaling pathway_Homo sapiens_hsa040621.02474505
44Allograft rejection_Homo sapiens_hsa053301.01601974
45Protein digestion and absorption_Homo sapiens_hsa049740.98519239
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97832154
47Homologous recombination_Homo sapiens_hsa034400.93862278
48Malaria_Homo sapiens_hsa051440.93609732
49Epstein-Barr virus infection_Homo sapiens_hsa051690.91830473
50Mineral absorption_Homo sapiens_hsa049780.90649240
51Viral myocarditis_Homo sapiens_hsa054160.88755054
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88524504
53Hepatitis B_Homo sapiens_hsa051610.83929075
54Arachidonic acid metabolism_Homo sapiens_hsa005900.83774711
55Vitamin digestion and absorption_Homo sapiens_hsa049770.83046984
56Proteasome_Homo sapiens_hsa030500.81014802
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80266224
58Toxoplasmosis_Homo sapiens_hsa051450.77504141
59Shigellosis_Homo sapiens_hsa051310.76432084
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76095460
61Non-small cell lung cancer_Homo sapiens_hsa052230.75202763
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74348797
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72572815
64HTLV-I infection_Homo sapiens_hsa051660.71181458
65Histidine metabolism_Homo sapiens_hsa003400.70821329
66Apoptosis_Homo sapiens_hsa042100.70721053
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70307767
68Pertussis_Homo sapiens_hsa051330.70115337
69Galactose metabolism_Homo sapiens_hsa000520.69904693
70Influenza A_Homo sapiens_hsa051640.65243536
71Legionellosis_Homo sapiens_hsa051340.64250570
72Linoleic acid metabolism_Homo sapiens_hsa005910.64224652
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.62038385
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61624988
75African trypanosomiasis_Homo sapiens_hsa051430.61211027
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60953997
77Viral carcinogenesis_Homo sapiens_hsa052030.60279147
78Pancreatic secretion_Homo sapiens_hsa049720.59090799
79Platelet activation_Homo sapiens_hsa046110.58995478
80Pancreatic cancer_Homo sapiens_hsa052120.58854242
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.58654176
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.57844579
83Amoebiasis_Homo sapiens_hsa051460.57682343
84Starch and sucrose metabolism_Homo sapiens_hsa005000.54391517
85VEGF signaling pathway_Homo sapiens_hsa043700.54142617
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52975255
87PPAR signaling pathway_Homo sapiens_hsa033200.50042402
88Autoimmune thyroid disease_Homo sapiens_hsa053200.49819582
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48704741
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48608354
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46893208
92Prion diseases_Homo sapiens_hsa050200.46310614
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43520908
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42534116
95Nucleotide excision repair_Homo sapiens_hsa034200.42410914
96Ether lipid metabolism_Homo sapiens_hsa005650.42221855
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41214671
98p53 signaling pathway_Homo sapiens_hsa041150.40240606
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39924036
100Acute myeloid leukemia_Homo sapiens_hsa052210.39555071
101Sulfur relay system_Homo sapiens_hsa041220.39496141
102Retinol metabolism_Homo sapiens_hsa008300.37687772
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37613210
104Folate biosynthesis_Homo sapiens_hsa007900.37181253
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37093280
106Arginine and proline metabolism_Homo sapiens_hsa003300.37007326
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36191417
108TNF signaling pathway_Homo sapiens_hsa046680.34121354
109Staphylococcus aureus infection_Homo sapiens_hsa051500.33866706
110Chronic myeloid leukemia_Homo sapiens_hsa052200.32896129
111Spliceosome_Homo sapiens_hsa030400.32231731
112Bile secretion_Homo sapiens_hsa049760.31572422
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30877753
114Graft-versus-host disease_Homo sapiens_hsa053320.30326298
115Fatty acid degradation_Homo sapiens_hsa000710.30210146
116Long-term potentiation_Homo sapiens_hsa047200.29461987
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29183013
118Small cell lung cancer_Homo sapiens_hsa052220.28886649
119Glycerolipid metabolism_Homo sapiens_hsa005610.28052919
120Hepatitis C_Homo sapiens_hsa051600.27597881
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27541231
122Prolactin signaling pathway_Homo sapiens_hsa049170.27312283
123Phenylalanine metabolism_Homo sapiens_hsa003600.26162343
124GnRH signaling pathway_Homo sapiens_hsa049120.24784006
125HIF-1 signaling pathway_Homo sapiens_hsa040660.24715712
126Caffeine metabolism_Homo sapiens_hsa002320.24579982
127Chemical carcinogenesis_Homo sapiens_hsa052040.23630306
128Pyrimidine metabolism_Homo sapiens_hsa002400.22049718
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.22045112
130Thyroid hormone synthesis_Homo sapiens_hsa049180.21584926
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20687884
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20262025
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19816513
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19198737
135Systemic lupus erythematosus_Homo sapiens_hsa053220.18283989
136MAPK signaling pathway_Homo sapiens_hsa040100.18229753
137Inositol phosphate metabolism_Homo sapiens_hsa005620.15150021
138MicroRNAs in cancer_Homo sapiens_hsa052060.13948527
139Salmonella infection_Homo sapiens_hsa051320.13643555
140Insulin resistance_Homo sapiens_hsa049310.13619094
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13469324
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.12100466
143Lysosome_Homo sapiens_hsa041420.11551802
144Vibrio cholerae infection_Homo sapiens_hsa051100.10351200
145Glioma_Homo sapiens_hsa052140.10190975

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