IGLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)7.98753821
2V(D)J recombination (GO:0033151)7.97962511
3purine deoxyribonucleotide catabolic process (GO:0009155)7.79258526
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.69338922
5deoxyribonucleotide catabolic process (GO:0009264)6.44066412
6positive regulation by host of viral transcription (GO:0043923)6.35183080
7purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)6.21532972
8regulation of histone H3-K9 methylation (GO:0051570)6.12436157
9deoxyribose phosphate catabolic process (GO:0046386)6.08920783
10DNA unwinding involved in DNA replication (GO:0006268)5.86406437
11purine deoxyribonucleotide metabolic process (GO:0009151)5.68384868
12purine nucleotide salvage (GO:0032261)5.65703825
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.62208608
14autophagic vacuole fusion (GO:0000046)5.57409998
15deoxyribonucleoside triphosphate metabolic process (GO:0009200)5.53852255
16B cell receptor signaling pathway (GO:0050853)5.35371482
17protein localization to kinetochore (GO:0034501)5.33548633
18nucleotide salvage (GO:0043173)5.31663082
19regulation of B cell apoptotic process (GO:0002902)5.19819866
20negative regulation of histone methylation (GO:0031061)5.14467656
21protein-DNA complex disassembly (GO:0032986)5.09519779
22nucleosome disassembly (GO:0006337)5.09519779
23positive regulation of B cell differentiation (GO:0045579)5.06957046
24natural killer cell differentiation (GO:0001779)5.02988662
25modulation of growth of symbiont involved in interaction with host (GO:0044144)4.99995145
26regulation of growth of symbiont in host (GO:0044126)4.99995145
27negative regulation of growth of symbiont in host (GO:0044130)4.99995145
28negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.99995145
29cellular hyperosmotic response (GO:0071474)4.93932980
302-deoxyribonucleotide metabolic process (GO:0009394)4.88568772
31DNA topological change (GO:0006265)4.79597960
32L-serine transport (GO:0015825)4.78767810
33pyrimidine nucleotide catabolic process (GO:0006244)4.70553567
34serine transport (GO:0032329)4.68585812
35lens fiber cell development (GO:0070307)4.66383288
36negative regulation of thymocyte apoptotic process (GO:0070244)4.61260161
37protein localization to chromosome, centromeric region (GO:0071459)4.61041904
38deoxyribose phosphate metabolic process (GO:0019692)4.58935280
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.55406111
40organelle membrane fusion (GO:0090174)4.53896672
41positive regulation of granulocyte differentiation (GO:0030854)4.50872783
42sister chromatid segregation (GO:0000819)4.43898021
43mitotic sister chromatid cohesion (GO:0007064)4.41606814
44regulation of NFAT protein import into nucleus (GO:0051532)4.36531184
45vesicle targeting (GO:0006903)4.33328934
46mature B cell differentiation involved in immune response (GO:0002313)4.25698715
47mucosal-associated lymphoid tissue development (GO:0048537)4.20850711
48Peyers patch development (GO:0048541)4.20850711
49positive regulation of histone deacetylation (GO:0031065)4.17736925
50B cell proliferation (GO:0042100)4.17716149
51tachykinin receptor signaling pathway (GO:0007217)4.17496013
52T cell lineage commitment (GO:0002360)4.17376073
53negative regulation of phagocytosis (GO:0050765)4.11866064
54deoxyribonucleotide metabolic process (GO:0009262)4.09447476
55killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.08468150
56disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.08468150
57ribosomal small subunit assembly (GO:0000028)4.07342047
58somatic diversification of immune receptors via germline recombination within a single locus (GO:0004.04420821
59somatic cell DNA recombination (GO:0016444)4.04420821
60mitotic sister chromatid segregation (GO:0000070)4.02036019
61base-excision repair, AP site formation (GO:0006285)3.99595388
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.92162197
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.90333578
64phosphatidylglycerol biosynthetic process (GO:0006655)3.87631610
65DNA strand elongation involved in DNA replication (GO:0006271)3.86065378
66regulation of mitochondrial translation (GO:0070129)3.85618939
67positive regulation of chromosome segregation (GO:0051984)3.83280217
68establishment of integrated proviral latency (GO:0075713)3.82165000
69regulation of chemokine biosynthetic process (GO:0045073)3.80696923
70positive regulation of vascular permeability (GO:0043117)3.73697649
71positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.70962724
72somatic diversification of immune receptors (GO:0002200)3.70470992
73regulation of germinal center formation (GO:0002634)3.67104326
74negative regulation of RNA splicing (GO:0033119)3.66280373
75DNA strand elongation (GO:0022616)3.65988125
76histamine secretion (GO:0001821)3.65243962
77regulation of penile erection (GO:0060405)3.64546950
78regulation of DNA endoreduplication (GO:0032875)3.64465454
79negative regulation of cell size (GO:0045792)3.64412596
80regulation of granulocyte differentiation (GO:0030852)3.64407102
81DNA ligation (GO:0006266)3.63468905
82telomere maintenance via semi-conservative replication (GO:0032201)3.62603537
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62509648
84viral transcription (GO:0019083)3.59634896
85protein complex biogenesis (GO:0070271)3.58365216
86immunoglobulin mediated immune response (GO:0016064)3.58268052
87lipopolysaccharide biosynthetic process (GO:0009103)3.57374263
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56566108
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.56566108
90NADH dehydrogenase complex assembly (GO:0010257)3.56566108
91mannosylation (GO:0097502)3.55733222
92mitotic chromosome condensation (GO:0007076)3.55621748
93modulation by host of symbiont transcription (GO:0052472)3.54547618
94modulation by host of viral transcription (GO:0043921)3.54547618
95response to vitamin E (GO:0033197)3.53381733
96negative regulation of gene expression, epigenetic (GO:0045814)3.50911838
97positive regulation of mitotic sister chromatid separation (GO:1901970)3.48981642
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48981642
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48981642
100negative regulation of lymphocyte apoptotic process (GO:0070229)3.48458037
101mitochondrial respiratory chain complex assembly (GO:0033108)3.47039191
102UV protection (GO:0009650)3.46955376
103negative regulation of bone resorption (GO:0045779)3.45439596
104cellular extravasation (GO:0045123)3.44339445
105mitotic recombination (GO:0006312)3.44303437
106positive regulation of gamma-delta T cell activation (GO:0046645)3.42963344
107mitochondrial calcium ion transport (GO:0006851)3.42705467
108translational termination (GO:0006415)3.38551343
109positive regulation of lamellipodium assembly (GO:0010592)3.36959281
110cellular response to interferon-beta (GO:0035458)3.35875991
111purine-containing compound salvage (GO:0043101)3.34845508
112chromatin silencing (GO:0006342)3.34166557
113positive regulation of histone H3-K4 methylation (GO:0051571)3.32484164
114pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.32122780
115positive regulation of megakaryocyte differentiation (GO:0045654)3.31542805
116protein localization to chromosome (GO:0034502)3.30569696
117regulation of histone methylation (GO:0031060)3.29675034
118T cell homeostasis (GO:0043029)3.28240687
119iron-sulfur cluster assembly (GO:0016226)3.27931798
120metallo-sulfur cluster assembly (GO:0031163)3.27931798
121pyrimidine-containing compound salvage (GO:0008655)3.27918151
122pyrimidine nucleoside salvage (GO:0043097)3.27918151
123pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.27736578
124modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.27283879
125alternative mRNA splicing, via spliceosome (GO:0000380)3.23309746
126positive regulation of Rap GTPase activity (GO:0032854)3.23177215
127ATP-dependent chromatin remodeling (GO:0043044)3.22988238
128negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22517839
129translesion synthesis (GO:0019985)3.22127851
130positive regulation of transcription regulatory region DNA binding (GO:2000679)3.21211831
131telomere maintenance via recombination (GO:0000722)3.20521822
132B cell differentiation (GO:0030183)3.18884906
133chaperone mediated protein folding requiring cofactor (GO:0051085)3.18741564
134deoxyribose phosphate biosynthetic process (GO:0046385)3.17374710
1352-deoxyribonucleotide biosynthetic process (GO:0009265)3.17374710
136pseudouridine synthesis (GO:0001522)3.16559121
137lipopolysaccharide metabolic process (GO:0008653)3.16504012
138cGMP-mediated signaling (GO:0019934)3.16426560
139positive regulation of protein deacetylation (GO:0090312)3.14823940
140translational elongation (GO:0006414)3.14312415
141nucleotide-excision repair, DNA gap filling (GO:0006297)3.13220078
142DNA duplex unwinding (GO:0032508)3.11112845
143negative regulation of granulocyte differentiation (GO:0030853)3.10430516
144DNA geometric change (GO:0032392)3.08322152
145antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07872439
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07872439
147regulation of B cell differentiation (GO:0045577)3.06614321
148cytochrome complex assembly (GO:0017004)3.05892896
149protein complex disassembly (GO:0043241)3.05023987
150adaptation of signaling pathway (GO:0023058)3.04292828
151positive regulation of gene expression, epigenetic (GO:0045815)3.03262123
152neutrophil mediated immunity (GO:0002446)3.02565762
153regulation of extracellular matrix disassembly (GO:0010715)3.01462091
154hepatocyte apoptotic process (GO:0097284)3.01031579
155establishment of viral latency (GO:0019043)3.00723397
156determination of adult lifespan (GO:0008340)3.00042446
157mature B cell differentiation (GO:0002335)2.97103329
158nucleoside salvage (GO:0043174)2.96978876
159purine nucleobase biosynthetic process (GO:0009113)2.96227233
160positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.95836869
161DNA deamination (GO:0045006)2.93998779
162nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93946412
163negative regulation of myeloid cell apoptotic process (GO:0033033)2.92572997
164positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91530324
165mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90782831
166chaperone-mediated protein transport (GO:0072321)2.90092693
167seminiferous tubule development (GO:0072520)2.89459091
168negative regulation of multicellular organism growth (GO:0040015)2.84816555
169B cell mediated immunity (GO:0019724)2.83718386
170mast cell degranulation (GO:0043303)2.83489170
171mast cell activation involved in immune response (GO:0002279)2.83489170
172reactive oxygen species biosynthetic process (GO:1903409)2.82318917
173histamine transport (GO:0051608)2.81384089
174negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.80851812
175lymphocyte homeostasis (GO:0002260)2.80524111
176ribosomal small subunit biogenesis (GO:0042274)2.80209887
177negative regulation of mRNA processing (GO:0050686)2.79446593
178DNA replication initiation (GO:0006270)2.78565003
179positive regulation of prostaglandin secretion (GO:0032308)2.74439945
180response to interferon-beta (GO:0035456)2.73636089
181fucose catabolic process (GO:0019317)2.72422331
182L-fucose metabolic process (GO:0042354)2.72422331
183L-fucose catabolic process (GO:0042355)2.72422331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.34038568
2MYC_22102868_ChIP-Seq_BL_Human4.77817849
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.99044984
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76829954
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37001530
6VDR_21846776_ChIP-Seq_THP-1_Human3.32287190
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13193576
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05586136
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.90650094
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69054828
11SCL_19346495_ChIP-Seq_HPC-7_Human2.53674503
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.51169807
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46143252
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45208355
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43081647
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33704344
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29656631
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28938497
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23114890
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19956238
21CIITA_25753668_ChIP-Seq_RAJI_Human2.17356136
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16398839
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16257971
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.14643185
25* UTX_26944678_Chip-Seq_JUKART_Human2.07506834
26VDR_24763502_ChIP-Seq_THP-1_Human2.07219076
27TCF7_22412390_ChIP-Seq_EML_Mouse2.00376041
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.00324058
29E2F7_22180533_ChIP-Seq_HELA_Human10.7582903
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.99462433
31MYB_26560356_Chip-Seq_TH2_Human1.97637481
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93871862
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92188265
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.91596030
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89251144
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89020807
37MAF_26560356_Chip-Seq_TH1_Human1.88856750
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88730740
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.86908329
40MYB_26560356_Chip-Seq_TH1_Human1.84651448
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83864512
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75547154
43GABP_19822575_ChIP-Seq_HepG2_Human1.72652999
44RUNX_20019798_ChIP-Seq_JUKART_Human1.72185028
45AR_21909140_ChIP-Seq_LNCAP_Human1.71875326
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70883819
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66861024
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63453227
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62515048
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61096169
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60098983
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59907785
53* KDM2B_26808549_Chip-Seq_DND41_Human1.59053238
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.58988439
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58437710
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.58357028
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57822302
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57307660
59BCL6_27268052_Chip-Seq_Bcells_Human1.56011782
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.53644063
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52532867
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51777127
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.51083636
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51039749
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48468804
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45596403
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43565912
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43130521
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42325894
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41021654
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39747290
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39194648
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38859454
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.34102702
75XRN2_22483619_ChIP-Seq_HELA_Human1.33963004
76SPI1_23127762_ChIP-Seq_K562_Human1.33679762
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30810993
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.29580328
79SPI1_23547873_ChIP-Seq_NB4_Human1.28702831
80P68_20966046_ChIP-Seq_HELA_Human1.27228596
81P300_27268052_Chip-Seq_Bcells_Human1.27063738
82MAF_26560356_Chip-Seq_TH2_Human1.25350433
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25322461
84FOXP3_21729870_ChIP-Seq_TREG_Human1.23566325
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22928059
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22914594
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22409747
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22029155
89BCOR_27268052_Chip-Seq_Bcells_Human1.21681331
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20684331
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20585674
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20152128
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18119726
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.17796768
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.16170967
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.15148296
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14138500
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12468553
99KDM5A_27292631_Chip-Seq_BREAST_Human1.12067022
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11960566
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11469228
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11233521
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11032409
104SPI1_20517297_ChIP-Seq_HL60_Human1.11021911
105TTF2_22483619_ChIP-Seq_HELA_Human1.09699102
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09555162
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09166431
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08431413
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07996028
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06734136
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06388675
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06349353
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05948398
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04227608
115E2F1_20622854_ChIP-Seq_HELA_Human1.04223304
116PHF8_20622854_ChIP-Seq_HELA_Human1.03122239
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01043527
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00742595
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00339776
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99977750
121IRF8_27001747_Chip-Seq_BMDM_Mouse0.99894030
122DCP1A_22483619_ChIP-Seq_HELA_Human0.99770225
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99273145
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.98054335
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97683150
126GATA3_27048872_Chip-Seq_THYMUS_Human0.95723650
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95142190
128VDR_23849224_ChIP-Seq_CD4+_Human0.95140467
129NCOR1_26117541_ChIP-Seq_K562_Human0.92755906
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92482828
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91436757
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89132984
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86363849
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86118345
135EZH2_22144423_ChIP-Seq_EOC_Human0.85548734
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84325973
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82394810
138* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82019132
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80091760
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79779025
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.78426584
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77535051
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75920544
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74624381
145LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74525605
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73386711
147GATA1_22025678_ChIP-Seq_K562_Human0.72296103
148PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71782626
149CHD1_26751641_Chip-Seq_LNCaP_Human0.71637043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.63419675
2MP0009697_abnormal_copulation4.52612854
3MP0002396_abnormal_hematopoietic_system3.68109412
4MP0010094_abnormal_chromosome_stability3.67639112
5MP0004808_abnormal_hematopoietic_stem3.10339313
6* MP0001800_abnormal_humoral_immune2.99858424
7MP0000685_abnormal_immune_system2.94758295
8MP0005645_abnormal_hypothalamus_physiol2.68248490
9MP0005397_hematopoietic_system_phenotyp2.66735308
10MP0001545_abnormal_hematopoietic_system2.66735308
11* MP0002398_abnormal_bone_marrow2.64766833
12MP0009379_abnormal_foot_pigmentation2.52181164
13MP0003111_abnormal_nucleus_morphology2.51172908
14MP0000372_irregular_coat_pigmentation2.49803027
15MP0008057_abnormal_DNA_replication2.48987200
16MP0003693_abnormal_embryo_hatching2.42934759
17MP0000703_abnormal_thymus_morphology2.42927678
18MP0003077_abnormal_cell_cycle2.42174337
19MP0005075_abnormal_melanosome_morpholog2.36869560
20* MP0000689_abnormal_spleen_morphology2.34401346
21* MP0002452_abnormal_antigen_presenting2.28918321
22MP0004233_abnormal_muscle_weight2.23156715
23MP0002653_abnormal_ependyma_morphology2.20027027
24* MP0002722_abnormal_immune_system2.19865196
25MP0005387_immune_system_phenotype2.15202234
26MP0001790_abnormal_immune_system2.15202234
27MP0002148_abnormal_hypersensitivity_rea2.14263823
28MP0006036_abnormal_mitochondrial_physio2.13228945
29MP0004957_abnormal_blastocyst_morpholog2.12549483
30* MP0000716_abnormal_immune_system2.10156701
31MP0010307_abnormal_tumor_latency2.10023883
32MP0005671_abnormal_response_to2.05453517
33MP0010352_gastrointestinal_tract_polyps2.02410014
34* MP0002420_abnormal_adaptive_immunity1.95880321
35MP0003646_muscle_fatigue1.95855224
36MP0003303_peritoneal_inflammation1.95804215
37MP0009785_altered_susceptibility_to1.94690059
38* MP0001819_abnormal_immune_cell1.92966297
39* MP0002723_abnormal_immune_serum1.91392699
40MP0000490_abnormal_crypts_of1.89424962
41MP0002019_abnormal_tumor_incidence1.85266246
42MP0004147_increased_porphyrin_level1.84076044
43* MP0002429_abnormal_blood_cell1.78054203
44MP0003300_gastrointestinal_ulcer1.76854180
45MP0004947_skin_inflammation1.74959713
46MP0003436_decreased_susceptibility_to1.73480115
47MP0001835_abnormal_antigen_presentation1.69889003
48MP0005220_abnormal_exocrine_pancreas1.68187106
49MP0002166_altered_tumor_susceptibility1.67132979
50MP0003763_abnormal_thymus_physiology1.64791882
51MP0006054_spinal_hemorrhage1.62546689
52MP0003806_abnormal_nucleotide_metabolis1.60829689
53MP0005451_abnormal_body_composition1.60232564
54MP0005000_abnormal_immune_tolerance1.56026579
55MP0002822_catalepsy1.54677455
56MP0005076_abnormal_cell_differentiation1.47282991
57MP0005464_abnormal_platelet_physiology1.45841438
58MP0005266_abnormal_metabolism1.42609141
59MP0001661_extended_life_span1.41438101
60MP0003252_abnormal_bile_duct1.41266532
61MP0008877_abnormal_DNA_methylation1.39826797
62MP0001853_heart_inflammation1.39225966
63MP0001730_embryonic_growth_arrest1.39076240
64MP0003183_abnormal_peptide_metabolism1.38386745
65MP0010234_abnormal_vibrissa_follicle1.37946036
66MP0010155_abnormal_intestine_physiology1.37864863
67MP0003718_maternal_effect1.37431328
68MP0008058_abnormal_DNA_repair1.36105060
69MP0008007_abnormal_cellular_replicative1.35262225
70MP0000350_abnormal_cell_proliferation1.35015180
71MP0005058_abnormal_lysosome_morphology1.34330303
72MP0009333_abnormal_splenocyte_physiolog1.31431887
73MP0008961_abnormal_basal_metabolism1.30681993
74MP0006035_abnormal_mitochondrial_morpho1.29233425
75MP0008873_increased_physiological_sensi1.27366510
76MP0009764_decreased_sensitivity_to1.25445727
77MP0001764_abnormal_homeostasis1.23933266
78MP0002405_respiratory_system_inflammati1.23770374
79MP0003186_abnormal_redox_activity1.21926147
80MP0005025_abnormal_response_to1.21151337
81MP0002876_abnormal_thyroid_physiology1.20797879
82MP0000462_abnormal_digestive_system1.20393175
83MP0009780_abnormal_chondrocyte_physiolo1.15491593
84MP0005084_abnormal_gallbladder_morpholo1.14977729
85MP0008469_abnormal_protein_level1.12534438
86MP0004185_abnormal_adipocyte_glucose1.12392899
87MP0000427_abnormal_hair_cycle1.11402987
88MP0003191_abnormal_cellular_cholesterol1.09254616
89MP0003786_premature_aging1.08030718
90MP0002006_tumorigenesis1.00980156
91MP0000358_abnormal_cell_content/1.00755307
92MP0000313_abnormal_cell_death1.00464244
93MP0009840_abnormal_foam_cell0.98650517
94MP0009765_abnormal_xenobiotic_induced0.98072334
95MP0005376_homeostasis/metabolism_phenot0.97193744
96MP0001879_abnormal_lymphatic_vessel0.95356994
97MP0002419_abnormal_innate_immunity0.94019366
98MP0001873_stomach_inflammation0.92737654
99MP0002970_abnormal_white_adipose0.91408988
100MP0008875_abnormal_xenobiotic_pharmacok0.90051534
101MP0001881_abnormal_mammary_gland0.89147596
102MP0003984_embryonic_growth_retardation0.88396694
103MP0005166_decreased_susceptibility_to0.87736735
104MP0002060_abnormal_skin_morphology0.87047967
105MP0001915_intracranial_hemorrhage0.86811055
106MP0001727_abnormal_embryo_implantation0.85873336
107MP0008872_abnormal_physiological_respon0.84416972
108MP0003638_abnormal_response/metabolism_0.84032222
109MP0002080_prenatal_lethality0.83918995
110MP0005380_embryogenesis_phenotype0.83200207
111MP0001672_abnormal_embryogenesis/_devel0.83200207
112MP0009763_increased_sensitivity_to0.82897783
113MP0004782_abnormal_surfactant_physiolog0.82561364
114MP0002088_abnormal_embryonic_growth/wei0.82206172
115MP0000681_abnormal_thyroid_gland0.81615867
116MP0005319_abnormal_enzyme/_coenzyme0.78630145
117MP0005584_abnormal_enzyme/coenzyme_acti0.78574235
118MP0000858_altered_metastatic_potential0.78502364
119MP0002132_abnormal_respiratory_system0.78336263
120MP0005501_abnormal_skin_physiology0.78331487
121MP0001845_abnormal_inflammatory_respons0.77894464
122MP0005174_abnormal_tail_pigmentation0.75885075
123MP0003075_altered_response_to0.73772535
124MP0001533_abnormal_skeleton_physiology0.73269043
125MP0009931_abnormal_skin_appearance0.72820217
126MP0002160_abnormal_reproductive_system0.72688252
127MP0004197_abnormal_fetal_growth/weight/0.72189076
128MP0000477_abnormal_intestine_morphology0.70544086
129MP0001697_abnormal_embryo_size0.69087350
130MP0000377_abnormal_hair_follicle0.68874334
131MP0008932_abnormal_embryonic_tissue0.68570677
132MP0003866_abnormal_defecation0.68501215
133MP0003943_abnormal_hepatobiliary_system0.66972790
134MP0001905_abnormal_dopamine_level0.66574459
135MP0000465_gastrointestinal_hemorrhage0.66226172
136MP0003566_abnormal_cell_adhesion0.65374696
137MP0003787_abnormal_imprinting0.65132288
138MP0001663_abnormal_digestive_system0.64030139
139MP0002086_abnormal_extraembryonic_tissu0.63931993
140MP0008995_early_reproductive_senescence0.63204606
141MP0008874_decreased_physiological_sensi0.63010133
142MP0008770_decreased_survivor_rate0.62325206
143MP0002083_premature_death0.57464908
144MP0009672_abnormal_birth_weight0.55942852
145MP0005621_abnormal_cell_physiology0.55642191

Predicted human phenotypes

RankGene SetZ-score
1* Agammaglobulinemia (HP:0004432)8.12756666
2Thyroiditis (HP:0100646)7.75881057
3* Cellulitis (HP:0100658)7.52648983
4B lymphocytopenia (HP:0010976)7.09823125
5Abnormality of B cell number (HP:0010975)7.09823125
6* Verrucae (HP:0200043)6.56075010
7* Papilloma (HP:0012740)6.56075010
8Panhypogammaglobulinemia (HP:0003139)5.85137581
9Severe combined immunodeficiency (HP:0004430)5.48346292
10Hypoplasia of the thymus (HP:0000778)5.43143672
11Chronic sinusitis (HP:0011109)5.17341145
12Small epiphyses (HP:0010585)4.98289019
13Combined immunodeficiency (HP:0005387)4.94479590
14Recurrent viral infections (HP:0004429)4.49478698
15Vertebral arch anomaly (HP:0008438)4.47627539
16Abnormality of the intervertebral disk (HP:0005108)4.41898530
17* Meningitis (HP:0001287)4.25158952
18Recurrent bronchitis (HP:0002837)4.08928246
19Increased IgE level (HP:0003212)4.04944139
20* Sepsis (HP:0100806)3.98546999
21* Osteomyelitis (HP:0002754)3.97909236
22Acute necrotizing encephalopathy (HP:0006965)3.96410338
23Abnormal mitochondria in muscle tissue (HP:0008316)3.94919248
24T lymphocytopenia (HP:0005403)3.94877255
25Type I transferrin isoform profile (HP:0003642)3.85108141
26Elevated erythrocyte sedimentation rate (HP:0003565)3.77883975
27Hypoproteinemia (HP:0003075)3.75968508
28Autoimmune hemolytic anemia (HP:0001890)3.70893437
29Abnormality of T cell number (HP:0011839)3.64952088
30Mitochondrial inheritance (HP:0001427)3.63121034
31Hypoplasia of the capital femoral epiphysis (HP:0003090)3.58832529
32Acute encephalopathy (HP:0006846)3.42324088
33Hepatocellular necrosis (HP:0001404)3.39381066
34Mesangial abnormality (HP:0001966)3.22596741
35IgM deficiency (HP:0002850)3.17738336
36Eosinophilia (HP:0001880)3.17593835
37Microvesicular hepatic steatosis (HP:0001414)3.16677560
38Abnormality of the fingertips (HP:0001211)3.13931672
39Progressive macrocephaly (HP:0004481)3.13796067
40Increased CSF lactate (HP:0002490)3.13668315
41Recurrent otitis media (HP:0000403)3.11767280
42Hepatic necrosis (HP:0002605)3.09632535
43Cerebral palsy (HP:0100021)3.06903958
44Hypergammaglobulinemia (HP:0010702)3.03733706
45Flattened epiphyses (HP:0003071)3.01870396
46Aplasia/Hypoplasia of the thymus (HP:0010515)2.99498285
47Autoimmune thrombocytopenia (HP:0001973)2.96203970
48Ulnar bowing (HP:0003031)2.88546513
49Recurrent fungal infections (HP:0002841)2.86528105
50Chronic otitis media (HP:0000389)2.85896349
51Cutaneous melanoma (HP:0012056)2.85311808
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.85301822
53Absent epiphyses (HP:0010577)2.85301822
54Gastrointestinal inflammation (HP:0004386)2.83883001
55Mitral stenosis (HP:0001718)2.82678773
56Long eyelashes (HP:0000527)2.78992252
57Abnormality of T cells (HP:0002843)2.76980715
58Obstructive lung disease (HP:0006536)2.75671176
59Chronic obstructive pulmonary disease (HP:0006510)2.75671176
60Volvulus (HP:0002580)2.75501754
61Abnormality of the thymus (HP:0000777)2.73013386
62Dicarboxylic aciduria (HP:0003215)2.71999485
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71999485
64Granulocytopenia (HP:0001913)2.71647109
65Abnormal protein glycosylation (HP:0012346)2.70821486
66Abnormal glycosylation (HP:0012345)2.70821486
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70821486
68Abnormal protein N-linked glycosylation (HP:0012347)2.70821486
69Cerebral edema (HP:0002181)2.69628812
70Cutis marmorata (HP:0000965)2.69098728
71Abnormality of the prostate (HP:0008775)2.68935838
72Colitis (HP:0002583)2.68286224
73Increased intramyocellular lipid droplets (HP:0012240)2.60387030
74Acute lymphatic leukemia (HP:0006721)2.60284852
75IgG deficiency (HP:0004315)2.57559583
76Multiple enchondromatosis (HP:0005701)2.53427949
77Inflammation of the large intestine (HP:0002037)2.52644189
78* Skin rash (HP:0000988)2.47833635
79Increased muscle lipid content (HP:0009058)2.46756589
80Abnormality of eosinophils (HP:0001879)2.41911497
81Reticulocytopenia (HP:0001896)2.39946310
82Arthropathy (HP:0003040)2.38360315
83Erythroderma (HP:0001019)2.38357588
84Lactic acidosis (HP:0003128)2.37220223
85* Recurrent pneumonia (HP:0006532)2.34610789
86Progressive microcephaly (HP:0000253)2.31731809
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30724677
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30724677
89Patellar aplasia (HP:0006443)2.27134439
90Limited elbow extension (HP:0001377)2.26000969
91Exercise intolerance (HP:0003546)2.23940739
92Chronic mucocutaneous candidiasis (HP:0002728)2.16950169
93Recurrent cutaneous fungal infections (HP:0011370)2.16950169
94Bronchitis (HP:0012387)2.14894909
95Progressive muscle weakness (HP:0003323)2.14777360
96Neutropenia (HP:0001875)2.11305793
97Respiratory failure (HP:0002878)2.10150276
98Irregular vertebral endplates (HP:0003301)2.08923062
99* Recurrent lower respiratory tract infections (HP:0002783)2.08840451
100Reduced antithrombin III activity (HP:0001976)2.06606347
101Lymphoma (HP:0002665)2.06445642
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04921057
103Ankyloglossia (HP:0010296)2.04609404
104Abnormality of cells of the lymphoid lineage (HP:0012140)2.04232253
105Aplasia/Hypoplasia of the patella (HP:0006498)2.03585497
106Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03582267
107Hypertensive crisis (HP:0100735)2.02214125
108Cupped ribs (HP:0000887)2.00621820
109Vertebral clefting (HP:0008428)1.99847546
110Mediastinal lymphadenopathy (HP:0100721)1.99826845
111Large eyes (HP:0001090)1.98992795
112Lymphopenia (HP:0001888)1.97920191
113Increased serum lactate (HP:0002151)1.95767127
114Recurrent sinusitis (HP:0011108)1.95696791
1153-Methylglutaconic aciduria (HP:0003535)1.93547538
116Ragged-red muscle fibers (HP:0003200)1.93475134
117Abnormality of the tricuspid valve (HP:0001702)1.91612026
118Sparse scalp hair (HP:0002209)1.91350787
119Petechiae (HP:0000967)1.91269048
120Abnormality of T cell physiology (HP:0011840)1.88259371
121Abnormality of endocrine pancreas physiology (HP:0012093)1.86859941
122Abnormality of the pancreatic islet cells (HP:0006476)1.86859941
123Neoplasm of the adrenal gland (HP:0100631)1.86654850
124Neoplasm of the adrenal cortex (HP:0100641)1.86228591
125Emotional lability (HP:0000712)1.86011082
126Villous atrophy (HP:0011473)1.83763434
127Abnormality of small intestinal villus morphology (HP:0011472)1.83763434
128Increased hepatocellular lipid droplets (HP:0006565)1.82891937
129Severe visual impairment (HP:0001141)1.82717032
130Abnormality of the pleura (HP:0002103)1.80530809
131Lipid accumulation in hepatocytes (HP:0006561)1.80003765
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79482683
133Hyperthyroidism (HP:0000836)1.79133960
134Thrombocytosis (HP:0001894)1.78889815
135Prostate neoplasm (HP:0100787)1.78698855
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77738241
137Abnormality of chromosome segregation (HP:0002916)1.77314356
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.74847995
139Abnormality of the parathyroid morphology (HP:0011766)1.74772653
140Increased nuchal translucency (HP:0010880)1.74187955
141Barrel-shaped chest (HP:0001552)1.72212784
142Asymmetry of the thorax (HP:0001555)1.71860666
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71091203
144Metaphyseal cupping (HP:0003021)1.69755517
145Optic disc pallor (HP:0000543)1.68452119
146Thoracic kyphosis (HP:0002942)1.67671813
147Prolonged bleeding time (HP:0003010)1.67022320
148Enlarged penis (HP:0000040)1.66981936
149Increased density of long bones (HP:0006392)1.66367990
150Leukocytosis (HP:0001974)1.65713255
151Prolonged neonatal jaundice (HP:0006579)1.65596209
152Abnormality of cells of the erythroid lineage (HP:0012130)1.65372728
153Opisthotonus (HP:0002179)1.65152103
154Lethargy (HP:0001254)1.64943048
155Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.64893227
156* Skin ulcer (HP:0200042)1.63177565
157Abnormal number of erythroid precursors (HP:0012131)1.61790892
158Abnormality of subcutaneous fat tissue (HP:0001001)1.61717539
159* Dehydration (HP:0001944)1.61394081
160Spontaneous hematomas (HP:0007420)1.61281342
161* External ear malformation (HP:0008572)1.60983392
162Bowed forearm bones (HP:0003956)1.57930447
163Bowing of the arm (HP:0006488)1.57930447
164Macroorchidism (HP:0000053)1.57897498
165Aortic regurgitation (HP:0001659)1.57329799
166Slow-growing hair (HP:0002217)1.57257698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K108.19043263
2VRK26.08297791
3EEF2K6.05643566
4KDR4.75313999
5BCKDK4.15659053
6KIT3.50204541
7ERN13.10614958
8PIM22.96216379
9NUAK12.94144351
10ARAF2.81844408
11NEK22.51358940
12SIK22.49090012
13NME22.35969528
14PKN22.24055246
15RPS6KB22.10823973
16TESK12.07194922
17GRK62.05281406
18STK101.95616839
19CLK11.93665550
20CDC71.91373178
21MAP4K11.88868385
22STK41.88705054
23FGFR21.81483150
24TBK11.79870273
25SYK1.73102832
26CDK41.68280763
27MAP3K111.66607020
28NLK1.62717152
29CDK121.61213285
30TAOK31.57123967
31ZAK1.52678395
32FRK1.52622376
33MAPK121.50714986
34MAPK111.48755110
35BTK1.46865597
36BUB11.46331567
37FES1.43711538
38ABL21.43147083
39LRRK21.36051710
40MAPKAPK31.28011545
41SCYL21.25510742
42CSF1R1.25012934
43LIMK11.24041921
44TRIB31.19510278
45TESK21.12172753
46CDK81.12042697
47PIK3CG1.09841335
48MAPK41.08413302
49PASK1.07260428
50MAP4K21.02887969
51HCK1.00773179
52RIPK40.99896892
53SIK10.99612352
54TLK10.98279503
55PBK0.95274249
56IKBKE0.92123896
57PIM10.92110061
58MAP3K70.91885039
59HIPK20.91071313
60MAPK130.89729196
61CDK60.88608255
62DAPK10.88269831
63MAPKAPK50.87398073
64WEE10.86884743
65BMPR20.86187206
66RPS6KB10.84718949
67TTK0.80291057
68MAP3K80.79032754
69UHMK10.77962332
70FGFR30.77895203
71PLK40.76229564
72BMPR1B0.72649034
73ATR0.72402226
74CDK190.70894256
75RPS6KA50.68639181
76DYRK20.65961470
77LYN0.65131657
78TGFBR10.64573195
79CCNB10.63121705
80SRPK10.62692084
81MELK0.61962084
82TRPM70.61672301
83RAF10.59089409
84AURKB0.58664309
85BRD40.57830261
86MARK20.54961664
87BRSK10.53719672
88DYRK1B0.53669731
89FLT30.53206525
90CHEK10.53146808
91CDK90.51310439
92INSRR0.50706680
93CDK20.49921424
94CDK140.49381540
95TYK20.48636448
96BRAF0.48370394
97TNK20.48080968
98MAPKAPK20.47522493
99ITK0.46887281
100IKBKB0.46275585
101EIF2AK30.45750308
102LCK0.44444558
103STK30.44023690
104CDK70.43784393
105DYRK30.41999886
106MST40.41479158
107NEK10.40972038
108CSNK2A20.40503365
109PRKCH0.39869397
110MTOR0.39515738
111PRKCQ0.38939352
112PLK10.38294781
113MARK30.37860991
114CDK150.37532592
115VRK10.37386214
116TRIM280.37018578
117ATM0.36810023
118CDK11A0.36256928
119PTK60.35822908
120CSNK1D0.35696848
121ZAP700.35686028
122CDK180.35468881
123CHEK20.34767838
124CSNK2A10.33235267
125MATK0.33022635
126MKNK10.32755058
127AURKA0.32249316
128ICK0.32059175
129GRK70.31957415
130CDK10.31755573
131TAF10.31081234
132TXK0.30461957
133ALK0.28494313
134MAPK70.27047607
135STK160.27032461
136PDK10.27022633
137PIK3CA0.26981083
138RPS6KL10.26847812
139RPS6KC10.26847812
140PLK30.26510001
141RPS6KA40.26293128
142GRK50.26066320
143TEC0.25736683
144BLK0.25103918
145PRKCI0.24792896
146MAPK140.24470836
147JAK30.24021367
148CAMK2G0.18556243
149OBSCN0.17720311
150MAPK30.16966785
151PRKD10.15791973
152IRAK30.13615818
153AKT10.13022140
154MAP2K30.12677814
155PRKDC0.12127180

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053405.71284338
2B cell receptor signaling pathway_Homo sapiens_hsa046624.19632484
3DNA replication_Homo sapiens_hsa030303.79859774
4Non-homologous end-joining_Homo sapiens_hsa034503.48309861
5Base excision repair_Homo sapiens_hsa034103.04653324
6Mismatch repair_Homo sapiens_hsa034303.01725736
7Proteasome_Homo sapiens_hsa030502.78721674
8Asthma_Homo sapiens_hsa053102.52214254
9Cell cycle_Homo sapiens_hsa041102.46623428
10Oxidative phosphorylation_Homo sapiens_hsa001902.45976704
11Parkinsons disease_Homo sapiens_hsa050122.43157832
12Sulfur relay system_Homo sapiens_hsa041222.43062029
13SNARE interactions in vesicular transport_Homo sapiens_hsa041302.21199540
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17919705
15RNA polymerase_Homo sapiens_hsa030202.16989859
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08427032
17Ribosome_Homo sapiens_hsa030102.02127374
18Spliceosome_Homo sapiens_hsa030401.92481110
19Non-small cell lung cancer_Homo sapiens_hsa052231.84878862
20Chronic myeloid leukemia_Homo sapiens_hsa052201.78375223
21Glioma_Homo sapiens_hsa052141.72880374
22Homologous recombination_Homo sapiens_hsa034401.70258814
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69698072
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62990722
25Allograft rejection_Homo sapiens_hsa053301.61330719
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59843711
27Huntingtons disease_Homo sapiens_hsa050161.53689054
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.51968199
29One carbon pool by folate_Homo sapiens_hsa006701.46964022
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45206293
31Autoimmune thyroid disease_Homo sapiens_hsa053201.42828999
32Alzheimers disease_Homo sapiens_hsa050101.42374401
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41345147
34Acute myeloid leukemia_Homo sapiens_hsa052211.41064505
35Renin-angiotensin system_Homo sapiens_hsa046141.40927139
36mRNA surveillance pathway_Homo sapiens_hsa030151.31380591
37Systemic lupus erythematosus_Homo sapiens_hsa053221.30852447
38Graft-versus-host disease_Homo sapiens_hsa053321.30779938
39mTOR signaling pathway_Homo sapiens_hsa041501.30627467
40Fatty acid elongation_Homo sapiens_hsa000621.29872831
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27814157
42Olfactory transduction_Homo sapiens_hsa047401.26467636
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26395564
44Osteoclast differentiation_Homo sapiens_hsa043801.25336397
45Viral carcinogenesis_Homo sapiens_hsa052031.24180314
46Nucleotide excision repair_Homo sapiens_hsa034201.22430333
47Type I diabetes mellitus_Homo sapiens_hsa049401.21479050
48p53 signaling pathway_Homo sapiens_hsa041151.20168507
49Glutathione metabolism_Homo sapiens_hsa004801.18540762
50Peroxisome_Homo sapiens_hsa041461.16003539
51RNA transport_Homo sapiens_hsa030131.13041132
52MicroRNAs in cancer_Homo sapiens_hsa052061.12371374
53Colorectal cancer_Homo sapiens_hsa052101.12029695
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11733531
55Pancreatic cancer_Homo sapiens_hsa052121.08707272
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07812028
57Protein export_Homo sapiens_hsa030601.04340042
58HTLV-I infection_Homo sapiens_hsa051661.03302358
59FoxO signaling pathway_Homo sapiens_hsa040681.03077279
60Hepatitis B_Homo sapiens_hsa051611.02954016
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02448093
62Sulfur metabolism_Homo sapiens_hsa009201.01296238
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01122241
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99563004
65Staphylococcus aureus infection_Homo sapiens_hsa051500.94957154
66Inositol phosphate metabolism_Homo sapiens_hsa005620.92390040
67Phototransduction_Homo sapiens_hsa047440.92270304
68Measles_Homo sapiens_hsa051620.91498102
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91131434
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.90428406
71Alcoholism_Homo sapiens_hsa050340.90060367
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89693463
73Fanconi anemia pathway_Homo sapiens_hsa034600.88285186
74Lysine degradation_Homo sapiens_hsa003100.86871660
75Prostate cancer_Homo sapiens_hsa052150.86440118
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.85348379
77Small cell lung cancer_Homo sapiens_hsa052220.85252968
78HIF-1 signaling pathway_Homo sapiens_hsa040660.84934637
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83565797
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83020041
81Herpes simplex infection_Homo sapiens_hsa051680.82973239
82Pentose phosphate pathway_Homo sapiens_hsa000300.82011849
83Phenylalanine metabolism_Homo sapiens_hsa003600.81211782
84VEGF signaling pathway_Homo sapiens_hsa043700.81110819
85Epstein-Barr virus infection_Homo sapiens_hsa051690.79938542
86Platelet activation_Homo sapiens_hsa046110.79783414
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.79371402
88Shigellosis_Homo sapiens_hsa051310.78245105
89Pyrimidine metabolism_Homo sapiens_hsa002400.78065732
90Cardiac muscle contraction_Homo sapiens_hsa042600.77838130
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77281433
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77133518
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76200949
94ErbB signaling pathway_Homo sapiens_hsa040120.75639249
95Apoptosis_Homo sapiens_hsa042100.74294287
96Fatty acid metabolism_Homo sapiens_hsa012120.73327663
97Type II diabetes mellitus_Homo sapiens_hsa049300.72758469
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71127570
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70865347
100Oocyte meiosis_Homo sapiens_hsa041140.70369947
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69737222
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.68978871
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.68866087
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.68773192
105Leishmaniasis_Homo sapiens_hsa051400.68537484
106Insulin resistance_Homo sapiens_hsa049310.68403507
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68354911
108Metabolic pathways_Homo sapiens_hsa011000.67234869
109Caffeine metabolism_Homo sapiens_hsa002320.67126496
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66824472
111Endometrial cancer_Homo sapiens_hsa052130.65385897
112Tyrosine metabolism_Homo sapiens_hsa003500.65128049
113N-Glycan biosynthesis_Homo sapiens_hsa005100.64619110
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64256664
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61508577
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.61315775
117RNA degradation_Homo sapiens_hsa030180.58549342
118Chemokine signaling pathway_Homo sapiens_hsa040620.56789199
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55614210
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55586808
121Carbon metabolism_Homo sapiens_hsa012000.54061798
122Butanoate metabolism_Homo sapiens_hsa006500.53775811
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52586780
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52351089
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.52081717
126Antigen processing and presentation_Homo sapiens_hsa046120.51414320
127Viral myocarditis_Homo sapiens_hsa054160.49397083
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48015054
129T cell receptor signaling pathway_Homo sapiens_hsa046600.47363434
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47223385
131Choline metabolism in cancer_Homo sapiens_hsa052310.46062957
132AMPK signaling pathway_Homo sapiens_hsa041520.45667242
133Thyroid cancer_Homo sapiens_hsa052160.45408621
134Tryptophan metabolism_Homo sapiens_hsa003800.45120794
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45076504
136Proteoglycans in cancer_Homo sapiens_hsa052050.43932647
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.43819972
138Rheumatoid arthritis_Homo sapiens_hsa053230.43798366
139Selenocompound metabolism_Homo sapiens_hsa004500.43750053
140Fatty acid degradation_Homo sapiens_hsa000710.43677589
141Tuberculosis_Homo sapiens_hsa051520.43428846
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.42578270
143Ether lipid metabolism_Homo sapiens_hsa005650.41871805
144Folate biosynthesis_Homo sapiens_hsa007900.41151764
145Renal cell carcinoma_Homo sapiens_hsa052110.39370826
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39277277
147Arachidonic acid metabolism_Homo sapiens_hsa005900.38758771
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.38093266
149Insulin signaling pathway_Homo sapiens_hsa049100.36851473
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35953763
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35907008
152Influenza A_Homo sapiens_hsa051640.35198346
153Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34249050
154Hematopoietic cell lineage_Homo sapiens_hsa046400.31881525
155Toxoplasmosis_Homo sapiens_hsa051450.31703897
156Long-term potentiation_Homo sapiens_hsa047200.31327703
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30970816
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.30781018
159Purine metabolism_Homo sapiens_hsa002300.30162366
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29964570
161Pathways in cancer_Homo sapiens_hsa052000.29080645
162Pertussis_Homo sapiens_hsa051330.28926930
163Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28680895
164Regulation of autophagy_Homo sapiens_hsa041400.27138039
165Chemical carcinogenesis_Homo sapiens_hsa052040.24752675

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