IGLON5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.73106559
2locomotory exploration behavior (GO:0035641)5.70796180
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57656151
4vocalization behavior (GO:0071625)5.34657847
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23494832
6response to pheromone (GO:0019236)5.22317474
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11195404
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09217055
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.02435794
10presynaptic membrane assembly (GO:0097105)4.92784938
11regulation of synaptic vesicle exocytosis (GO:2000300)4.77164906
12regulation of glutamate receptor signaling pathway (GO:1900449)4.71786346
13presynaptic membrane organization (GO:0097090)4.70065414
14layer formation in cerebral cortex (GO:0021819)4.66391229
15protein localization to synapse (GO:0035418)4.57428125
16synaptic vesicle exocytosis (GO:0016079)4.52176736
17glutamate secretion (GO:0014047)4.38956459
18dendritic spine morphogenesis (GO:0060997)4.38394747
19exploration behavior (GO:0035640)4.32900519
20neuron cell-cell adhesion (GO:0007158)4.31793642
21nucleobase catabolic process (GO:0046113)4.25362450
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.24876559
23regulation of synaptic vesicle transport (GO:1902803)4.15790335
24neurotransmitter secretion (GO:0007269)4.10940480
25establishment of mitochondrion localization (GO:0051654)4.08884819
26gamma-aminobutyric acid transport (GO:0015812)3.95299390
27glycine transport (GO:0015816)3.93361256
28postsynaptic membrane organization (GO:0001941)3.92550328
29regulation of synapse structural plasticity (GO:0051823)3.86783221
30synaptic transmission, glutamatergic (GO:0035249)3.81238463
31dendrite morphogenesis (GO:0048813)3.80455969
32proline transport (GO:0015824)3.78140585
33regulation of neuronal synaptic plasticity (GO:0048168)3.77907904
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76504128
35cell migration in hindbrain (GO:0021535)3.70190431
36axonal fasciculation (GO:0007413)3.68909353
37glutamate receptor signaling pathway (GO:0007215)3.68880996
38neuron recognition (GO:0008038)3.68838833
39cellular potassium ion homeostasis (GO:0030007)3.67947736
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64020165
41cerebellar Purkinje cell differentiation (GO:0021702)3.63990294
42establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.62286533
43mitochondrion transport along microtubule (GO:0047497)3.62286533
44synaptic vesicle endocytosis (GO:0048488)3.58880074
45auditory behavior (GO:0031223)3.58000485
46central nervous system projection neuron axonogenesis (GO:0021952)3.56787159
47neurotransmitter-gated ion channel clustering (GO:0072578)3.55472074
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53250412
49neuron-neuron synaptic transmission (GO:0007270)3.45663996
50response to auditory stimulus (GO:0010996)3.45098980
51neuronal action potential propagation (GO:0019227)3.43172054
52positive regulation of synapse maturation (GO:0090129)3.42548100
53long-term memory (GO:0007616)3.41416933
54sodium ion export (GO:0071436)3.37219622
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.32995069
56cell communication by electrical coupling (GO:0010644)3.32737823
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29740540
58neurotransmitter transport (GO:0006836)3.29437339
59positive regulation of membrane potential (GO:0045838)3.24319410
60regulation of neurotransmitter secretion (GO:0046928)3.22116640
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20357151
62neuromuscular process controlling balance (GO:0050885)3.19411198
63regulation of vesicle fusion (GO:0031338)3.17918604
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11800178
65axon extension (GO:0048675)3.11472035
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10376769
67transmission of nerve impulse (GO:0019226)3.10003168
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09296650
69dendritic spine organization (GO:0097061)3.08967365
70cerebellar granule cell differentiation (GO:0021707)3.08868006
71axon extension involved in axon guidance (GO:0048846)3.08412784
72neuron projection extension involved in neuron projection guidance (GO:1902284)3.08412784
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07772717
74innervation (GO:0060384)3.04742955
75positive regulation of dendritic spine development (GO:0060999)3.03240563
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03109126
77regulation of postsynaptic membrane potential (GO:0060078)3.02385951
78membrane hyperpolarization (GO:0060081)2.99285709
79neuronal ion channel clustering (GO:0045161)2.98562523
80regulation of posttranscriptional gene silencing (GO:0060147)2.98453479
81regulation of gene silencing by miRNA (GO:0060964)2.98453479
82regulation of gene silencing by RNA (GO:0060966)2.98453479
83pyrimidine nucleobase catabolic process (GO:0006208)2.98266659
84planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96934298
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96501847
86synapse assembly (GO:0007416)2.96317649
87neuromuscular synaptic transmission (GO:0007274)2.95835685
88regulation of neurotransmitter levels (GO:0001505)2.95284045
89spinal cord development (GO:0021510)2.95221082
90regulation of neurotransmitter transport (GO:0051588)2.93977061
91cerebellar Purkinje cell layer development (GO:0021680)2.93577608
92activation of protein kinase A activity (GO:0034199)2.92853985
93positive regulation of neurotransmitter secretion (GO:0001956)2.92239995
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91011675
95regulation of synapse maturation (GO:0090128)2.89371045
96regulation of synaptic plasticity (GO:0048167)2.88694383
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87218503
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.87164604
99membrane depolarization during action potential (GO:0086010)2.86853757
100neuron projection extension (GO:1990138)2.86689437
101L-amino acid import (GO:0043092)2.86069942
102synapse organization (GO:0050808)2.85142792
103positive regulation of neurotransmitter transport (GO:0051590)2.83960559
104paraxial mesoderm development (GO:0048339)2.82400525
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81365083
106positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80959847
107neuromuscular process controlling posture (GO:0050884)2.79550200
108learning (GO:0007612)2.79221341
109alanine transport (GO:0032328)2.79108332
110establishment of nucleus localization (GO:0040023)2.78905291
111positive regulation of synapse assembly (GO:0051965)2.78844156
112adult walking behavior (GO:0007628)2.76692789
113potassium ion homeostasis (GO:0055075)2.76010739
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.75752129
115negative regulation of microtubule polymerization (GO:0031115)2.75227510
116regulation of dendritic spine morphogenesis (GO:0061001)2.75024993
117neuromuscular process (GO:0050905)2.74825998
118regulation of ARF protein signal transduction (GO:0032012)2.73514807
119cerebral cortex radially oriented cell migration (GO:0021799)2.72681553
120regulation of synapse assembly (GO:0051963)2.72428583
121membrane depolarization (GO:0051899)2.72148929
122regulation of respiratory system process (GO:0044065)2.72073502
123mechanosensory behavior (GO:0007638)2.71660789
124prepulse inhibition (GO:0060134)2.71162807
125histone arginine methylation (GO:0034969)2.69800489
126amino acid import (GO:0043090)2.69785039
127convergent extension (GO:0060026)2.69776124
128negative regulation of axonogenesis (GO:0050771)2.67725941
129apical protein localization (GO:0045176)2.67458118
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66563031
131neurofilament cytoskeleton organization (GO:0060052)2.65783364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63013479
2GBX2_23144817_ChIP-Seq_PC3_Human3.19251902
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03822641
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93020924
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89894344
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85358694
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85358694
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.71475060
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70769043
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59278995
11DROSHA_22980978_ChIP-Seq_HELA_Human2.58046301
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50032729
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.49511178
14REST_21632747_ChIP-Seq_MESCs_Mouse2.45868696
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39653152
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39354045
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39337945
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.38071878
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.37803467
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35963486
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35918612
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23790294
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22737141
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16152259
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13650690
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.99931843
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.88295775
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83245761
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82007547
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71717319
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70681303
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66204719
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61184499
34AR_21572438_ChIP-Seq_LNCaP_Human1.60977512
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54069071
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.52045816
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50378321
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.50366118
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50195217
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.49498205
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.43940659
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41922745
43SMAD4_21799915_ChIP-Seq_A2780_Human1.39805393
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38112704
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38112704
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38112704
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.38062212
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29472655
49KDM2B_26808549_Chip-Seq_K562_Human1.29368709
50CTCF_27219007_Chip-Seq_Bcells_Human1.29004180
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27192619
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.27008043
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23748846
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23021441
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22847296
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22600031
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22043201
58AR_19668381_ChIP-Seq_PC3_Human1.21999786
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.20248760
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19816315
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19592404
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19027770
63RNF2_27304074_Chip-Seq_NSC_Mouse1.18793947
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16777822
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15479340
66ZNF274_21170338_ChIP-Seq_K562_Hela1.15256384
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.14400497
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14287702
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14044911
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12843156
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12676150
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11425444
73POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10930263
74P300_19829295_ChIP-Seq_ESCs_Human1.10851547
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.10498596
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09947314
77AR_25329375_ChIP-Seq_VCAP_Human1.09682709
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.09340946
79STAT3_23295773_ChIP-Seq_U87_Human1.08819419
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08658944
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08363647
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08311246
83IGF1R_20145208_ChIP-Seq_DFB_Human1.06726731
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05896177
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05820232
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05745412
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04896514
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04575914
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01993418
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.01364788
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00997173
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.00715937
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00442442
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.00370676
95AHR_22903824_ChIP-Seq_MCF-7_Human0.99403475
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98347935
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98327597
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97270248
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96076884
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95920908
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95732567
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95183651
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95121345
104TCF4_23295773_ChIP-Seq_U87_Human0.95029362
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94457454
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94457454
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93699043
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93464483
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.93376931
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93362554
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93360322
112TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92717347
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.90611746
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88571143
115RUNX2_22187159_ChIP-Seq_PCA_Human0.88344493
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87783717
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87326321
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87248370
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86947423
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86852270
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85818560
122TAF15_26573619_Chip-Seq_HEK293_Human0.85386261
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.84804799
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84325985
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84145821
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.83639711
127TP53_18474530_ChIP-ChIP_U2OS_Human0.82938460
128SOX3_22085726_ChIP-Seq_NPCs_Mouse0.82484202
129POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.82398005
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81448774
131PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81362256
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81135588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.92040079
2MP0003880_abnormal_central_pattern4.01959836
3MP0003635_abnormal_synaptic_transmissio3.74348988
4MP0005423_abnormal_somatic_nervous3.65276909
5MP0004270_analgesia3.13961998
6MP0009046_muscle_twitch3.03272400
7MP0002063_abnormal_learning/memory/cond2.97088060
8MP0000569_abnormal_digit_pigmentation2.90380354
9MP0009745_abnormal_behavioral_response2.85682904
10MP0002064_seizures2.70610310
11MP0002734_abnormal_mechanical_nocicepti2.54500402
12MP0001968_abnormal_touch/_nociception2.53015435
13MP0001486_abnormal_startle_reflex2.50711922
14MP0002572_abnormal_emotion/affect_behav2.43101601
15MP0003136_yellow_coat_color2.42781622
16MP0000778_abnormal_nervous_system2.37060368
17MP0000566_synostosis2.15864624
18MP0002272_abnormal_nervous_system2.13975001
19MP0004858_abnormal_nervous_system2.13517249
20MP0002184_abnormal_innervation2.12739894
21MP0002735_abnormal_chemical_nociception1.98891618
22MP0005645_abnormal_hypothalamus_physiol1.95985872
23MP0002733_abnormal_thermal_nociception1.93768763
24MP0009780_abnormal_chondrocyte_physiolo1.91303816
25MP0002557_abnormal_social/conspecific_i1.88940612
26MP0003787_abnormal_imprinting1.88339723
27MP0001501_abnormal_sleep_pattern1.87553087
28MP0008569_lethality_at_weaning1.85934562
29MP0004811_abnormal_neuron_physiology1.85489679
30MP0006276_abnormal_autonomic_nervous1.85290959
31MP0002736_abnormal_nociception_after1.82876145
32MP0002067_abnormal_sensory_capabilities1.81799848
33MP0001970_abnormal_pain_threshold1.81241771
34MP0004885_abnormal_endolymph1.77551633
35MP0005646_abnormal_pituitary_gland1.77304296
36MP0000955_abnormal_spinal_cord1.75412415
37MP0001440_abnormal_grooming_behavior1.74847107
38MP0003122_maternal_imprinting1.72600549
39MP0003123_paternal_imprinting1.64786941
40MP0002882_abnormal_neuron_morphology1.56165524
41MP0010030_abnormal_orbit_morphology1.55521190
42MP0001502_abnormal_circadian_rhythm1.48606288
43MP0005386_behavior/neurological_phenoty1.48413369
44MP0004924_abnormal_behavior1.48413369
45MP0003878_abnormal_ear_physiology1.46793495
46MP0005377_hearing/vestibular/ear_phenot1.46793495
47MP0001984_abnormal_olfaction1.39840804
48MP0004133_heterotaxia1.38428753
49MP0003879_abnormal_hair_cell1.38253694
50MP0005551_abnormal_eye_electrophysiolog1.37947263
51MP0002066_abnormal_motor_capabilities/c1.33479068
52MP0008877_abnormal_DNA_methylation1.28237476
53MP0003119_abnormal_digestive_system1.26924090
54MP0002909_abnormal_adrenal_gland1.26656466
55MP0004742_abnormal_vestibular_system1.26221480
56MP0002152_abnormal_brain_morphology1.25809822
57MP0004142_abnormal_muscle_tone1.25407852
58MP0005257_abnormal_intraocular_pressure1.24450495
59MP0005623_abnormal_meninges_morphology1.22553523
60MP0000579_abnormal_nail_morphology1.21821316
61MP0005394_taste/olfaction_phenotype1.19557866
62MP0005499_abnormal_olfactory_system1.19557866
63MP0003633_abnormal_nervous_system1.16531322
64MP0002249_abnormal_larynx_morphology1.15654930
65MP0002822_catalepsy1.15492931
66MP0003890_abnormal_embryonic-extraembry1.14369345
67MP0003329_amyloid_beta_deposits1.12047963
68MP0001529_abnormal_vocalization1.10591640
69MP0006292_abnormal_olfactory_placode1.08020125
70MP0000537_abnormal_urethra_morphology1.07638742
71MP0002638_abnormal_pupillary_reflex1.06233457
72MP0001177_atelectasis1.05505958
73MP0003631_nervous_system_phenotype1.01211664
74MP0010386_abnormal_urinary_bladder1.00328865
75MP0001299_abnormal_eye_distance/1.00018138
76MP0005171_absent_coat_pigmentation1.00001753
77MP0000631_abnormal_neuroendocrine_gland0.99638132
78MP0003634_abnormal_glial_cell0.99545135
79MP0002752_abnormal_somatic_nervous0.99258720
80MP0003937_abnormal_limbs/digits/tail_de0.98953442
81MP0001293_anophthalmia0.98438953
82MP0003283_abnormal_digestive_organ0.98326521
83MP0003942_abnormal_urinary_system0.98014895
84MP0002229_neurodegeneration0.94397552
85MP0002233_abnormal_nose_morphology0.93666624
86MP0009672_abnormal_birth_weight0.92984829
87MP0005248_abnormal_Harderian_gland0.92907464
88MP0001188_hyperpigmentation0.92863242
89MP0002938_white_spotting0.91066683
90MP0003861_abnormal_nervous_system0.88323783
91MP0002089_abnormal_postnatal_growth/wei0.87946450
92MP0009053_abnormal_anal_canal0.87820016
93MP0002653_abnormal_ependyma_morphology0.87561158
94MP0004145_abnormal_muscle_electrophysio0.87455231
95MP0000428_abnormal_craniofacial_morphol0.86278860
96MP0003385_abnormal_body_wall0.85420228
97MP0002069_abnormal_eating/drinking_beha0.85129506
98MP0000534_abnormal_ureter_morphology0.84801642
99MP0003690_abnormal_glial_cell0.84173813
100MP0003632_abnormal_nervous_system0.83783980
101MP0001963_abnormal_hearing_physiology0.83710191
102MP0003567_abnormal_fetal_cardiomyocyte0.82190635
103MP0005253_abnormal_eye_physiology0.81726305
104MP0002116_abnormal_craniofacial_bone0.80503241
105MP0003172_abnormal_lysosome_physiology0.77433648
106MP0002697_abnormal_eye_size0.77181030
107MP0002090_abnormal_vision0.74740560
108MP0006072_abnormal_retinal_apoptosis0.73729453
109MP0001348_abnormal_lacrimal_gland0.73427950
110MP0004233_abnormal_muscle_weight0.71409352
111MP0003121_genomic_imprinting0.71361371
112MP0008789_abnormal_olfactory_epithelium0.70882841
113MP0005187_abnormal_penis_morphology0.68237104
114MP0002102_abnormal_ear_morphology0.68026221
115MP0001485_abnormal_pinna_reflex0.67868182
116MP0000920_abnormal_myelination0.66065321
117MP0000026_abnormal_inner_ear0.65982858
118MP0004085_abnormal_heartbeat0.64210594
119MP0008961_abnormal_basal_metabolism0.61419583
120MP0005195_abnormal_posterior_eye0.61138907
121MP0003938_abnormal_ear_development0.60183667
122MP0002081_perinatal_lethality0.58999646
123MP0000049_abnormal_middle_ear0.58262286
124MP0010769_abnormal_survival0.58088288
125MP0001905_abnormal_dopamine_level0.57867869
126MP0010770_preweaning_lethality0.56483747
127MP0002082_postnatal_lethality0.56483747

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.27401819
2Focal motor seizures (HP:0011153)5.24452805
3Focal seizures (HP:0007359)4.48014878
4Progressive cerebellar ataxia (HP:0002073)4.35410537
5Epileptic encephalopathy (HP:0200134)3.95639161
6Febrile seizures (HP:0002373)3.86238418
7Visual hallucinations (HP:0002367)3.83349726
8Supranuclear gaze palsy (HP:0000605)3.77579229
9Action tremor (HP:0002345)3.70244319
10Genetic anticipation (HP:0003743)3.35430563
11Mutism (HP:0002300)3.33676856
12Turricephaly (HP:0000262)3.12860992
13Ankle clonus (HP:0011448)3.11331789
14Atonic seizures (HP:0010819)3.02270778
15Broad-based gait (HP:0002136)2.90141624
16Generalized tonic-clonic seizures (HP:0002069)2.89840148
17Poor eye contact (HP:0000817)2.88949380
18Abnormality of the labia minora (HP:0012880)2.85208696
19Hepatoblastoma (HP:0002884)2.82185606
20Absence seizures (HP:0002121)2.76967729
21Hemiparesis (HP:0001269)2.75612909
22Drooling (HP:0002307)2.72665389
23Excessive salivation (HP:0003781)2.72665389
24Diplopia (HP:0000651)2.68788230
25Abnormality of binocular vision (HP:0011514)2.68788230
26Abnormal social behavior (HP:0012433)2.65060546
27Impaired social interactions (HP:0000735)2.65060546
28Urinary bladder sphincter dysfunction (HP:0002839)2.60628315
29Septo-optic dysplasia (HP:0100842)2.58367524
30Depression (HP:0000716)2.57288381
31Abnormal eating behavior (HP:0100738)2.56758228
32Torticollis (HP:0000473)2.52262634
33Postural instability (HP:0002172)2.52076577
34Gaze-evoked nystagmus (HP:0000640)2.49540350
35Trigonocephaly (HP:0000243)2.49146408
36Agitation (HP:0000713)2.47429449
37Dysdiadochokinesis (HP:0002075)2.46469329
38Dialeptic seizures (HP:0011146)2.45931154
39Hemiplegia (HP:0002301)2.45666933
40Insomnia (HP:0100785)2.39858290
41Truncal ataxia (HP:0002078)2.32794951
42Hyperventilation (HP:0002883)2.31122025
43Stereotypic behavior (HP:0000733)2.29751295
44Megalencephaly (HP:0001355)2.29658265
45Impaired vibration sensation in the lower limbs (HP:0002166)2.29261666
46Limb dystonia (HP:0002451)2.28877729
47Cutaneous syndactyly (HP:0012725)2.28493856
48Progressive inability to walk (HP:0002505)2.27968027
49Cortical dysplasia (HP:0002539)2.26713618
50Hyperacusis (HP:0010780)2.24622213
51High anterior hairline (HP:0009890)2.23333063
52Pointed chin (HP:0000307)2.22148745
53Bronchomalacia (HP:0002780)2.21987799
54Elfin facies (HP:0004428)2.16632551
55Focal dystonia (HP:0004373)2.15434654
56Polyphagia (HP:0002591)2.15272305
57Anxiety (HP:0000739)2.15009054
58Vitreoretinal degeneration (HP:0000655)2.14904871
59Inappropriate behavior (HP:0000719)2.14842673
60Central scotoma (HP:0000603)2.14541660
61Dysmetria (HP:0001310)2.13509675
62Absent speech (HP:0001344)2.12649512
63Abnormality of the corticospinal tract (HP:0002492)2.12022288
64Coronal craniosynostosis (HP:0004440)2.11745472
65Obstructive sleep apnea (HP:0002870)2.08817290
66Aqueductal stenosis (HP:0002410)2.08191028
67Cerebral inclusion bodies (HP:0100314)2.07874412
68Papilledema (HP:0001085)2.07630836
69Abnormality of the aortic arch (HP:0012303)2.06316097
70Annular pancreas (HP:0001734)2.05813802
71Abnormal hair whorl (HP:0010721)2.05772694
72Absent septum pellucidum (HP:0001331)2.04255383
73Impaired smooth pursuit (HP:0007772)2.03874361
74Choanal stenosis (HP:0000452)2.03664326
75Abnormality of the lower motor neuron (HP:0002366)2.03538579
76Amblyopia (HP:0000646)2.02691275
77Congenital stationary night blindness (HP:0007642)2.02659905
78Fetal akinesia sequence (HP:0001989)2.01320793
79Abnormality of the diencephalon (HP:0010662)2.00245124
80Lower limb amyotrophy (HP:0007210)1.99757622
81Urinary urgency (HP:0000012)1.98323392
82Short 4th metacarpal (HP:0010044)1.98143576
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98143576
84Anophthalmia (HP:0000528)1.97927436
85Spastic gait (HP:0002064)1.95941960
86Rib fusion (HP:0000902)1.95474418
87Craniofacial dystonia (HP:0012179)1.94165631
88Macroorchidism (HP:0000053)1.92883346
89Renal duplication (HP:0000075)1.92673489
90Broad metatarsal (HP:0001783)1.92239268
91Abnormality of ocular smooth pursuit (HP:0000617)1.90574273
92Lower limb muscle weakness (HP:0007340)1.90472632
93Broad thumb (HP:0011304)1.89763380
94Shallow orbits (HP:0000586)1.89539010
95Epileptiform EEG discharges (HP:0011182)1.88670766
96EEG with generalized epileptiform discharges (HP:0011198)1.88374528
97Overriding aorta (HP:0002623)1.88078369
98Status epilepticus (HP:0002133)1.86080523
99Renovascular hypertension (HP:0100817)1.84693040
100Generalized hypotonia (HP:0001290)1.83271127
101Abnormality of the septum pellucidum (HP:0007375)1.82890285
102Bradykinesia (HP:0002067)1.82727553
103Split foot (HP:0001839)1.82058076
104Flat cornea (HP:0007720)1.82003324
105Myelomeningocele (HP:0002475)1.81559382
106Hypsarrhythmia (HP:0002521)1.80108544
107Amyotrophic lateral sclerosis (HP:0007354)1.79324813
108Abnormality of the 4th metacarpal (HP:0010012)1.79019883
109Aplasia involving bones of the extremities (HP:0009825)1.78967513
110Aplasia involving bones of the upper limbs (HP:0009823)1.78967513
111Aplasia of the phalanges of the hand (HP:0009802)1.78967513
112Failure to thrive in infancy (HP:0001531)1.78934861
113Akinesia (HP:0002304)1.78025984
114Optic nerve hypoplasia (HP:0000609)1.77761967
115Spinal canal stenosis (HP:0003416)1.77652177
116Abnormality of salivation (HP:0100755)1.77161567
117Broad finger (HP:0001500)1.76835189
118Humeroradial synostosis (HP:0003041)1.76268741
119Synostosis involving the elbow (HP:0003938)1.76268741
120Hypoventilation (HP:0002791)1.75398625
121Pachygyria (HP:0001302)1.74672109
122Partial agenesis of the corpus callosum (HP:0001338)1.74329682
123Broad phalanges of the hand (HP:0009768)1.74203466
124Intention tremor (HP:0002080)1.74044686
125Cutaneous finger syndactyly (HP:0010554)1.73854291
126Neurofibrillary tangles (HP:0002185)1.73653465
127Termporal pattern (HP:0011008)1.73434346
128Insidious onset (HP:0003587)1.73434346
129Arnold-Chiari malformation (HP:0002308)1.73141719
130Narrow nasal bridge (HP:0000446)1.72642035
131Renal hypoplasia (HP:0000089)1.71053483
132Neoplasm of the heart (HP:0100544)1.69974922
133Sacral dimple (HP:0000960)1.68884058
134Sleep apnea (HP:0010535)1.68094711
135Apathy (HP:0000741)1.67236599
136Oligodactyly (HP:0012165)1.66331995
137Lissencephaly (HP:0001339)1.65818938
138Open mouth (HP:0000194)1.65777098
139Morphological abnormality of the middle ear (HP:0008609)1.64158925
140Broad long bones (HP:0005622)1.63256751
141Lower limb asymmetry (HP:0100559)1.62631950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.86914734
2NTRK33.81094588
3MAP3K93.13102527
4EPHA42.70544369
5MAP3K42.65707483
6MINK12.60905001
7SIK22.58023168
8PAK62.55745110
9MAP2K72.54305744
10NTRK22.32984600
11FGFR22.21949056
12PRKD32.11345887
13DAPK21.92911426
14CAMKK11.86363789
15LATS21.85077898
16MAPK131.78797927
17TNIK1.70077570
18STK381.67056000
19SIK31.60695944
20CASK1.57088551
21KSR11.53610119
22PHKG11.52214905
23PHKG21.52214905
24EPHB21.49688674
25CDK51.44598250
26MAP2K41.44000032
27PRPF4B1.38738914
28PLK21.31168747
29UHMK11.27369873
30MAP3K101.22201170
31PRKCG1.20876256
32NTRK11.20314493
33ERBB31.19146969
34CAMK1D1.17853857
35ALK1.14134188
36BCR1.11853432
37TAOK11.11560193
38MAP3K121.08005070
39MARK21.07543169
40EEF2K1.05450090
41KSR21.05102463
42PRKCH1.03559197
43WNK31.02781689
44LMTK21.01663328
45RIPK11.01559694
46WNK10.99315306
47SGK4940.98805903
48SGK2230.98805903
49GRK50.95584551
50TYRO30.93154033
51RIPK40.90841595
52CAMK1G0.90212187
53DYRK1A0.89387378
54MKNK10.89153384
55CDK180.89023342
56CDK150.88725706
57STK110.87598437
58SGK20.87176532
59SGK30.85711209
60CDC42BPA0.83364735
61PAK30.83180030
62DYRK20.82422880
63CDK140.80571610
64CAMK10.80401702
65DDR20.76541768
66CAMKK20.76201099
67CDK11A0.75547072
68CSNK1G20.75418288
69MKNK20.74938785
70SIK10.73688752
71RET0.72192483
72DYRK30.72187284
73DAPK10.71521702
74NEK60.70952542
75FES0.69121987
76PRKCZ0.68888626
77CAMK2A0.67921220
78CDC70.67757783
79BRD40.67035350
80CDK190.66905984
81ICK0.66342878
82FGFR10.63937326
83SGK10.63262753
84PKN10.62786455
85FGFR40.60958878
86ERBB20.60041881
87PNCK0.58639232
88CSNK1G30.58637429
89CSNK1E0.58147828
90PDGFRA0.57766295
91CAMK2B0.53982627
92FYN0.53316879
93TNK20.52733016
94ARAF0.52055120
95PASK0.51977353
96PRKCE0.50716747
97CAMK40.50638030
98CSNK1G10.50504172
99CSNK1D0.49063617
100RPS6KA20.48655416
101RPS6KA30.48409582
102DYRK1B0.48045342
103ROCK10.47479928
104BMX0.44956140
105OXSR10.44832921
106MAPK100.44516390
107CSNK1A1L0.44239165
108MAPK80.43686849
109PRKDC0.43074481
110ROCK20.42973937
111MAP3K20.42669749
112LATS10.40290111
113TAOK20.40128764
114BRAF0.39608334
115PINK10.37498006
116LIMK10.37262327
117BRSK10.35559299
118FER0.35138300
119PRKCB0.34938867
120MAPK90.34934316
121PRKAA10.34868098
122GSK3B0.34364144
123ADRBK10.34265108
124STK38L0.33279373
125SRC0.32815408
126PRKG10.32629910
127CDK120.31574112
128CSNK1A10.30859833

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43330514
2Synaptic vesicle cycle_Homo sapiens_hsa047213.17041138
3GABAergic synapse_Homo sapiens_hsa047272.53511001
4Circadian entrainment_Homo sapiens_hsa047132.36715696
5Olfactory transduction_Homo sapiens_hsa047402.36350653
6Glutamatergic synapse_Homo sapiens_hsa047242.34223880
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29929120
8Morphine addiction_Homo sapiens_hsa050322.28663639
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95321248
10Long-term potentiation_Homo sapiens_hsa047201.94062404
11Dopaminergic synapse_Homo sapiens_hsa047281.82917860
12Cholinergic synapse_Homo sapiens_hsa047251.79804770
13Salivary secretion_Homo sapiens_hsa049701.77556503
14Amphetamine addiction_Homo sapiens_hsa050311.76651263
15Insulin secretion_Homo sapiens_hsa049111.75464150
16Axon guidance_Homo sapiens_hsa043601.66128316
17Taste transduction_Homo sapiens_hsa047421.61071214
18Phototransduction_Homo sapiens_hsa047441.56962382
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55539748
20Gastric acid secretion_Homo sapiens_hsa049711.53379302
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50820065
22Cocaine addiction_Homo sapiens_hsa050301.46928234
23Serotonergic synapse_Homo sapiens_hsa047261.46641496
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43377976
25Long-term depression_Homo sapiens_hsa047301.42087489
26Oxytocin signaling pathway_Homo sapiens_hsa049211.40297319
27Type II diabetes mellitus_Homo sapiens_hsa049301.40212880
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36749555
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33893381
30Calcium signaling pathway_Homo sapiens_hsa040201.31115270
31Gap junction_Homo sapiens_hsa045401.29627089
32Renin secretion_Homo sapiens_hsa049241.28933443
33GnRH signaling pathway_Homo sapiens_hsa049121.22308375
34Glioma_Homo sapiens_hsa052141.20896675
35cAMP signaling pathway_Homo sapiens_hsa040241.15661180
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15368308
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14636482
38ErbB signaling pathway_Homo sapiens_hsa040121.13739536
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10063364
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05901314
41Estrogen signaling pathway_Homo sapiens_hsa049151.05771999
42Melanogenesis_Homo sapiens_hsa049161.02901218
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01273057
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.93206942
45Tight junction_Homo sapiens_hsa045300.92290860
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92233376
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90231696
48Endometrial cancer_Homo sapiens_hsa052130.88962425
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87043581
50Dilated cardiomyopathy_Homo sapiens_hsa054140.87026108
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86410215
52Collecting duct acid secretion_Homo sapiens_hsa049660.85737720
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84946203
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84173213
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.83624885
56MAPK signaling pathway_Homo sapiens_hsa040100.83192517
57Steroid biosynthesis_Homo sapiens_hsa001000.82978422
58Notch signaling pathway_Homo sapiens_hsa043300.81834226
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81547524
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79330370
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78111003
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77477950
63Dorso-ventral axis formation_Homo sapiens_hsa043200.77413842
64Adherens junction_Homo sapiens_hsa045200.77348097
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76986151
66Choline metabolism in cancer_Homo sapiens_hsa052310.76223321
67Wnt signaling pathway_Homo sapiens_hsa043100.73839059
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72003905
69Colorectal cancer_Homo sapiens_hsa052100.71735802
70Ras signaling pathway_Homo sapiens_hsa040140.71722542
71mTOR signaling pathway_Homo sapiens_hsa041500.71501727
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71410228
73Rap1 signaling pathway_Homo sapiens_hsa040150.71221951
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.70420916
75Type I diabetes mellitus_Homo sapiens_hsa049400.64151907
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63231836
77Renal cell carcinoma_Homo sapiens_hsa052110.62550920
78mRNA surveillance pathway_Homo sapiens_hsa030150.61297446
79Endocytosis_Homo sapiens_hsa041440.60939164
80Hedgehog signaling pathway_Homo sapiens_hsa043400.60689003
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59994785
82Pancreatic secretion_Homo sapiens_hsa049720.59335891
83Bile secretion_Homo sapiens_hsa049760.58775035
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.58692053
85Vibrio cholerae infection_Homo sapiens_hsa051100.57701058
86Oocyte meiosis_Homo sapiens_hsa041140.57366789
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57292071
88Vitamin B6 metabolism_Homo sapiens_hsa007500.56802143
89Non-small cell lung cancer_Homo sapiens_hsa052230.56607628
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56493671
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56107312
92Hippo signaling pathway_Homo sapiens_hsa043900.55685939
93Basal cell carcinoma_Homo sapiens_hsa052170.55573532
94Thyroid hormone synthesis_Homo sapiens_hsa049180.55421899
95Chemokine signaling pathway_Homo sapiens_hsa040620.55070519
96Protein digestion and absorption_Homo sapiens_hsa049740.52910846
97Ovarian steroidogenesis_Homo sapiens_hsa049130.52183848
98VEGF signaling pathway_Homo sapiens_hsa043700.51741479
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51700097
100Nitrogen metabolism_Homo sapiens_hsa009100.51458713
101Glucagon signaling pathway_Homo sapiens_hsa049220.51144297
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50831291
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50092066
104Melanoma_Homo sapiens_hsa052180.49898820
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49065647
106Lysine degradation_Homo sapiens_hsa003100.48148041
107Prion diseases_Homo sapiens_hsa050200.47791989
108AMPK signaling pathway_Homo sapiens_hsa041520.47106408
109Inositol phosphate metabolism_Homo sapiens_hsa005620.45189619
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44874559
111Cardiac muscle contraction_Homo sapiens_hsa042600.44399501
112Circadian rhythm_Homo sapiens_hsa047100.44163874
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44062626
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43334248
115Insulin signaling pathway_Homo sapiens_hsa049100.42914824
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42427269
117Alcoholism_Homo sapiens_hsa050340.41528454
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41269371
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.40725430
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40497281
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40188045
122Biosynthesis of amino acids_Homo sapiens_hsa012300.36943426
123Arginine and proline metabolism_Homo sapiens_hsa003300.31760892

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