IGLV1-44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)8.52556461
2positive regulation of respiratory burst (GO:0060267)7.16741426
3protein activation cascade (GO:0072376)6.28646413
4glomerular filtration (GO:0003094)6.06674272
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.91556462
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81707702
7antigen processing and presentation of endogenous antigen (GO:0019883)5.75151028
8renal filtration (GO:0097205)5.49503022
9immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.27852745
10Fc-gamma receptor signaling pathway (GO:0038094)5.27852745
11Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.27852745
12Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.25657659
13humoral immune response (GO:0006959)5.02079265
14regulation of respiratory burst (GO:0060263)4.83754648
15regulation of dendritic cell antigen processing and presentation (GO:0002604)4.62691654
16antimicrobial humoral response (GO:0019730)4.58408654
17antibacterial humoral response (GO:0019731)4.56634821
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47822064
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.45332097
20immunoglobulin mediated immune response (GO:0016064)4.28275083
21regulation of antigen processing and presentation (GO:0002577)4.27380331
22detection of bacterium (GO:0016045)4.19971640
23regulation of cellular extravasation (GO:0002691)4.09316846
24detection of other organism (GO:0098543)4.08956334
25positive regulation of antigen processing and presentation (GO:0002579)3.98209200
26negative regulation of cell killing (GO:0031342)3.94534846
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94534846
28interferon-gamma-mediated signaling pathway (GO:0060333)3.90071876
29production of molecular mediator involved in inflammatory response (GO:0002532)3.78653126
30type I interferon signaling pathway (GO:0060337)3.75534283
31cellular response to type I interferon (GO:0071357)3.75534283
32response to type I interferon (GO:0034340)3.73046072
33positive regulation of gamma-delta T cell activation (GO:0046645)3.57046295
34immune response-activating cell surface receptor signaling pathway (GO:0002429)3.56290938
35retina homeostasis (GO:0001895)3.38710566
36regulation of T-helper 1 cell differentiation (GO:0045625)3.37695726
37germinal center formation (GO:0002467)3.32358876
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.30726411
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29934119
40positive regulation of type 2 immune response (GO:0002830)3.27235629
41positive regulation of chemokine secretion (GO:0090197)3.24538742
42B cell mediated immunity (GO:0019724)3.20610237
43defense response to protozoan (GO:0042832)3.20426600
44positive regulation of pseudopodium assembly (GO:0031274)3.11489884
45dendritic cell chemotaxis (GO:0002407)3.09746085
46cellular response to interferon-gamma (GO:0071346)3.09262814
47regulation of chemokine secretion (GO:0090196)3.09203006
48detection of external biotic stimulus (GO:0098581)3.04638407
49NIK/NF-kappaB signaling (GO:0038061)3.03461658
50angiotensin maturation (GO:0002003)2.98660868
51B cell receptor signaling pathway (GO:0050853)2.97525626
52response to interferon-gamma (GO:0034341)2.91927227
53regulation of B cell receptor signaling pathway (GO:0050855)2.91320249
54myeloid dendritic cell differentiation (GO:0043011)2.84612024
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84004843
56positive regulation by organism of defense response of other organism involved in symbiotic interact2.84004843
57modulation by symbiont of host immune response (GO:0052553)2.84004843
58positive regulation by symbiont of host defense response (GO:0052509)2.84004843
59modulation by symbiont of host defense response (GO:0052031)2.84004843
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84004843
61regulation of T cell tolerance induction (GO:0002664)2.79573035
62regulation of T-helper 2 cell differentiation (GO:0045628)2.79221683
63regulation of pseudopodium assembly (GO:0031272)2.77320253
64immune response-activating signal transduction (GO:0002757)2.77246252
65activation of immune response (GO:0002253)2.73117327
66chronic inflammatory response (GO:0002544)2.72609546
67negative regulation of T-helper cell differentiation (GO:0045623)2.72428138
68negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72428138
69antigen processing and presentation via MHC class Ib (GO:0002475)2.72235756
70positive thymic T cell selection (GO:0045059)2.69318665
71response to protozoan (GO:0001562)2.66198620
72T cell costimulation (GO:0031295)2.65407121
73regulation of gamma-delta T cell activation (GO:0046643)2.65132079
74myeloid dendritic cell activation (GO:0001773)2.63364486
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.62471710
76lymphocyte costimulation (GO:0031294)2.61524302
77macrophage activation involved in immune response (GO:0002281)2.61425019
78dendritic cell migration (GO:0036336)2.60922078
79positive regulation of granulocyte chemotaxis (GO:0071624)2.58908483
80production of molecular mediator of immune response (GO:0002440)2.57139262
81T-helper 1 type immune response (GO:0042088)2.55705831
82detection of biotic stimulus (GO:0009595)2.55492556
83positive regulation of T cell migration (GO:2000406)2.54707782
84peptide catabolic process (GO:0043171)2.53133063
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51822495
86neutrophil activation involved in immune response (GO:0002283)2.50298916
87regulation of T cell migration (GO:2000404)2.49950869
88positive regulation of B cell differentiation (GO:0045579)2.49570290
89virion attachment to host cell (GO:0019062)2.47367078
90adhesion of symbiont to host cell (GO:0044650)2.47367078
91regulation of integrin activation (GO:0033623)2.47046249
92positive regulation of neutrophil chemotaxis (GO:0090023)2.46753286
93positive regulation of neutrophil migration (GO:1902624)2.46753286
94regulation of tolerance induction (GO:0002643)2.46225089
95regulation of type 2 immune response (GO:0002828)2.45943282
96negative regulation of myotube differentiation (GO:0010832)2.45779861
97defense response to Gram-negative bacterium (GO:0050829)2.45739749
98regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.44767227
99regulation of gamma-delta T cell differentiation (GO:0045586)2.44368072
100complement activation, classical pathway (GO:0006958)10.6890517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.11587955
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.77230064
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.65000171
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.27687944
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.04815367
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.97530036
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61149500
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59687514
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.43931289
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31518562
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29636550
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21373494
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16863398
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16085847
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13091600
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09380284
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03195955
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01471161
19VDR_24763502_ChIP-Seq_THP-1_Human1.83085389
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81752465
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.81713878
22VDR_21846776_ChIP-Seq_THP-1_Human1.80934615
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78472069
24RUNX_20019798_ChIP-Seq_JUKART_Human1.75479159
25LXR_22292898_ChIP-Seq_THP-1_Human1.74987280
26MYC_22102868_ChIP-Seq_BL_Human1.74572272
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70689322
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70113323
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66754627
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.63937706
31MAF_26560356_Chip-Seq_TH1_Human1.59294765
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.58879974
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56150558
34MYB_26560356_Chip-Seq_TH2_Human1.55978627
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55065227
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53359018
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52348293
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47897464
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45631260
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45046347
41SPI1_23127762_ChIP-Seq_K562_Human1.44258756
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.41998240
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.41674087
44TCF7_22412390_ChIP-Seq_EML_Mouse1.39681028
45SPI1_23547873_ChIP-Seq_NB4_Human1.38811465
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36457972
47UTX_26944678_Chip-Seq_JUKART_Human1.35444219
48MYB_26560356_Chip-Seq_TH1_Human1.35318873
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32797802
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32705325
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28473518
52VDR_24787735_ChIP-Seq_THP-1_Human1.27754741
53EGR1_19032775_ChIP-ChIP_M12_Human1.27744138
54SOX2_20726797_ChIP-Seq_SW620_Human1.25621323
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.22542275
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22469779
57CLOCK_20551151_ChIP-Seq_293T_Human1.19969261
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19012738
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18892505
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18629617
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17458355
62RACK7_27058665_Chip-Seq_MCF-7_Human1.17319035
63GATA1_19941826_ChIP-Seq_K562_Human1.17065499
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15433372
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.14073378
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.13714185
67SCL_19346495_ChIP-Seq_HPC-7_Human1.11758859
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11604931
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.11219471
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10896633
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10038006
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09188102
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06468951
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.05401544
75KDM2B_26808549_Chip-Seq_DND41_Human1.05383247
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05059973
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04763803
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02678328
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.02622140
80GATA4_25053715_ChIP-Seq_YYC3_Human1.01415025
81BCOR_27268052_Chip-Seq_Bcells_Human1.01069484
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00543120
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00046823
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99764198
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99309860
86BCL6_27268052_Chip-Seq_Bcells_Human0.98949211
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98422891
88LXR_22158963_ChIP-Seq_LIVER_Mouse0.97766811
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97684548
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97542933
91GATA6_25053715_ChIP-Seq_YYC3_Human0.97264435
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96963606
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96674977
94GATA1_22025678_ChIP-Seq_K562_Human0.94219742
95GATA3_27048872_Chip-Seq_THYMUS_Human0.92374455
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92103249
97MAF_26560356_Chip-Seq_TH2_Human0.91514641
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91013426
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90400759
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89378401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.33227360
2MP0001835_abnormal_antigen_presentation3.57741157
3MP0003303_peritoneal_inflammation3.48659334
4MP0001790_abnormal_immune_system3.20008237
5MP0005387_immune_system_phenotype3.20008237
6MP0003436_decreased_susceptibility_to3.18094288
7MP0010234_abnormal_vibrissa_follicle2.96626804
8MP0010155_abnormal_intestine_physiology2.82978008
9MP0001800_abnormal_humoral_immune2.79914080
10MP0000685_abnormal_immune_system2.75598902
11MP0005025_abnormal_response_to2.56289410
12MP0009785_altered_susceptibility_to2.47054161
13MP0005671_abnormal_response_to2.38744227
14MP0005000_abnormal_immune_tolerance2.35959165
15MP0002138_abnormal_hepatobiliary_system2.23102452
16MP0002452_abnormal_antigen_presenting2.22394783
17MP0002148_abnormal_hypersensitivity_rea2.20151673
18MP0003300_gastrointestinal_ulcer2.08856918
19MP0002723_abnormal_immune_serum2.06281374
20MP0000465_gastrointestinal_hemorrhage2.04562687
21MP0005275_abnormal_skin_tensile2.03741886
22MP0001873_stomach_inflammation2.01304160
23MP0002419_abnormal_innate_immunity2.00990327
24MP0001819_abnormal_immune_cell1.98941997
25MP0002420_abnormal_adaptive_immunity1.98511690
26MP0001533_abnormal_skeleton_physiology1.96619229
27MP0003866_abnormal_defecation1.94431459
28MP0005166_decreased_susceptibility_to1.86484295
29MP0004947_skin_inflammation1.82759136
30MP0006082_CNS_inflammation1.81454516
31MP0003183_abnormal_peptide_metabolism1.79528297
32MP0004264_abnormal_extraembryonic_tissu1.77260080
33MP0002166_altered_tumor_susceptibility1.76408317
34MP0001845_abnormal_inflammatory_respons1.71810885
35MP0003763_abnormal_thymus_physiology1.69433344
36MP0003191_abnormal_cellular_cholesterol1.61998904
37MP0005310_abnormal_salivary_gland1.52297203
38MP0008004_abnormal_stomach_pH1.50165529
39MP0010352_gastrointestinal_tract_polyps1.45853773
40MP0000716_abnormal_immune_system1.45845043
41MP0004782_abnormal_surfactant_physiolog1.45428560
42MP0009333_abnormal_splenocyte_physiolog1.45211194
43MP0002139_abnormal_hepatobiliary_system1.44344703
44MP0001663_abnormal_digestive_system1.40451077
45MP0002398_abnormal_bone_marrow1.35275548
46MP0002796_impaired_skin_barrier1.34944919
47MP0002405_respiratory_system_inflammati1.33948494
48MP0004858_abnormal_nervous_system1.33600970
49MP0005503_abnormal_tendon_morphology1.28292788
50MP0003448_altered_tumor_morphology1.27905602
51MP0005464_abnormal_platelet_physiology1.25260161
52MP0009840_abnormal_foam_cell1.23960547
53MP0005023_abnormal_wound_healing1.22101175
54MP0002006_tumorigenesis1.20763014
55MP0002933_joint_inflammation1.20358495
56MP0000858_altered_metastatic_potential1.19357509
57MP0003075_altered_response_to1.19246110
58MP0000490_abnormal_crypts_of1.17733699
59MP0003279_aneurysm1.16953177
60MP0008469_abnormal_protein_level1.15919182
61MP0003045_fibrosis1.14562343
62MP0005360_urolithiasis1.14491968
63MP0000343_altered_response_to1.13438278
64MP0002429_abnormal_blood_cell1.12702607
65MP0008438_abnormal_cutaneous_collagen1.11746683
66MP0000604_amyloidosis1.09781456
67MP0002998_abnormal_bone_remodeling1.05725976
68MP0000689_abnormal_spleen_morphology1.04862431
69MP0001851_eye_inflammation1.03656006
70MP0000477_abnormal_intestine_morphology1.02983693
71MP0002722_abnormal_immune_system1.02371084
72MP0005381_digestive/alimentary_phenotyp1.02104426
73MP0005390_skeleton_phenotype0.99867408
74MP0003453_abnormal_keratinocyte_physiol0.99769315
75MP0000249_abnormal_blood_vessel0.97631748
76MP0005058_abnormal_lysosome_morphology0.96787540
77MP0001666_abnormal_nutrient_absorption0.96560331
78MP0005085_abnormal_gallbladder_physiolo0.95380078
79MP0003091_abnormal_cell_migration0.94092907
80MP0009764_decreased_sensitivity_to0.93744015
81MP0008260_abnormal_autophagy0.92918077
82MP0005164_abnormal_response_to0.89749402
83MP0003828_pulmonary_edema0.89647564
84MP0004510_myositis0.88403052
85MP0003566_abnormal_cell_adhesion0.88372804
86MP0001958_emphysema0.85260887
87MP0002277_abnormal_respiratory_mucosa0.84738683
88MP0001664_abnormal_digestion0.79527105
89MP0002136_abnormal_kidney_physiology0.77255676
90MP0005388_respiratory_system_phenotype0.76864037
91MP0002133_abnormal_respiratory_system0.76864037
92MP0005451_abnormal_body_composition0.76752706
93MP0009278_abnormal_bone_marrow0.76409072
94MP0005409_darkened_coat_color0.74668276
95MP0001216_abnormal_epidermal_layer0.74354275
96MP0003329_amyloid_beta_deposits0.72276956
97MP0005165_increased_susceptibility_to0.71080288
98MP0005365_abnormal_bile_salt0.70992833
99MP0001853_heart_inflammation0.68901056
100MP0002396_abnormal_hematopoietic_system0.68650966

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.58882051
2Abnormality of macrophages (HP:0004311)5.02109392
3Eczematoid dermatitis (HP:0000976)4.96831174
4Prostate neoplasm (HP:0100787)4.94634953
5Malnutrition (HP:0004395)4.32884494
6Agammaglobulinemia (HP:0004432)4.32717180
7Abnormality of complement system (HP:0005339)4.05714964
8Vasculitis (HP:0002633)3.87895106
9Abnormality of the prostate (HP:0008775)3.78002251
10Complement deficiency (HP:0004431)3.76519721
11Glomerulonephritis (HP:0000099)3.76299868
12Colitis (HP:0002583)3.75709699
13Recurrent bronchitis (HP:0002837)3.72335022
14Gastrointestinal stroma tumor (HP:0100723)3.62907073
15Recurrent bacterial skin infections (HP:0005406)3.60101344
16Cellulitis (HP:0100658)3.57623034
17Meningitis (HP:0001287)3.48244138
18Increased IgE level (HP:0003212)3.45150589
19Recurrent abscess formation (HP:0002722)3.41037103
20Inflammation of the large intestine (HP:0002037)3.18195040
21Abnormality of cells of the lymphoid lineage (HP:0012140)3.16364621
22Nephritis (HP:0000123)3.15994500
23Spontaneous hematomas (HP:0007420)3.12864930
24Osteomyelitis (HP:0002754)3.12204729
25Skin rash (HP:0000988)3.10348084
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.07104658
27Gastrointestinal inflammation (HP:0004386)3.06772077
28Gastrointestinal infarctions (HP:0005244)3.00531754
29Premature loss of primary teeth (HP:0006323)2.94881101
30Urticaria (HP:0001025)2.89287485
31Myositis (HP:0100614)2.85127767
32Mediastinal lymphadenopathy (HP:0100721)2.84351607
33Abnormality of B cell number (HP:0010975)2.84079601
34Gingivitis (HP:0000230)2.83727039
35Recurrent sinusitis (HP:0011108)2.79334435
36Emphysema (HP:0002097)2.79057890
37Recurrent gram-negative bacterial infections (HP:0005420)2.77787781
38Recurrent viral infections (HP:0004429)2.75321886
39Orchitis (HP:0100796)2.74363315
40Abnormality of the nasal mucosa (HP:0000433)2.72912417
41Chronic obstructive pulmonary disease (HP:0006510)2.68941403
42Obstructive lung disease (HP:0006536)2.68941403
43Chronic diarrhea (HP:0002028)2.68636390
44Leukocytosis (HP:0001974)2.67028051
45Chronic otitis media (HP:0000389)2.61123333
46Hemoptysis (HP:0002105)2.54620731
47Pustule (HP:0200039)2.53897485
48Recurrent skin infections (HP:0001581)2.53599735
49Papilloma (HP:0012740)2.53512707
50Verrucae (HP:0200043)2.53512707
51Pulmonary infiltrates (HP:0002113)2.49386763
52Elevated erythrocyte sedimentation rate (HP:0003565)2.49002852
53Hyperactive renin-angiotensin system (HP:0000841)2.46309448
54Villous atrophy (HP:0011473)2.46108367
55Abnormality of small intestinal villus morphology (HP:0011472)2.46108367
56Recurrent fungal infections (HP:0002841)2.43968281
57B lymphocytopenia (HP:0010976)2.40688400
58Recurrent pneumonia (HP:0006532)2.36913351
59Restrictive lung disease (HP:0002091)2.27846788
60Hypergammaglobulinemia (HP:0010702)2.27759539
61Abnormality of male internal genitalia (HP:0000022)2.26283161
62Alopecia of scalp (HP:0002293)2.25284903
63Bronchitis (HP:0012387)2.25210760
64Skin ulcer (HP:0200042)2.22639093
65Retrobulbar optic neuritis (HP:0100654)2.22626253
66Optic neuritis (HP:0100653)2.22626253
67Recurrent lower respiratory tract infections (HP:0002783)2.22411815
68Recurrent cutaneous fungal infections (HP:0011370)2.22355274
69Chronic mucocutaneous candidiasis (HP:0002728)2.22355274
70Purpura (HP:0000979)2.20811858
71Panhypogammaglobulinemia (HP:0003139)2.18912098
72Nasal polyposis (HP:0100582)2.16409943
73Lymphopenia (HP:0001888)2.16080184
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15330703
75Sepsis (HP:0100806)2.14393039
76Chest pain (HP:0100749)2.06368354
77Right ventricular cardiomyopathy (HP:0011663)2.05824795
78Increased IgM level (HP:0003496)2.05064719
79Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04228502
80Interstitial pulmonary disease (HP:0006530)2.03792432
81Hematochezia (HP:0002573)2.03548727
82Encephalitis (HP:0002383)1.98848995
83Decreased circulating renin level (HP:0003351)1.98642052
84Hypermelanotic macule (HP:0001034)1.96894189
85Abnormality of the peritoneum (HP:0002585)1.91645191
86Keratoconjunctivitis sicca (HP:0001097)1.91451576
87Neoplasm of the lung (HP:0100526)1.90519315
88IgM deficiency (HP:0002850)1.90194351
89Abnormality of the pleura (HP:0002103)1.89136865
90Thick nail (HP:0001805)1.86629521
91Hemorrhage of the eye (HP:0011885)1.86346151
92Polycythemia (HP:0001901)1.85728690
93Abnormality of T cell physiology (HP:0011840)1.85633361
94Xerostomia (HP:0000217)1.81276483
95Autoimmune hemolytic anemia (HP:0001890)1.80270057
96Metaphyseal cupping (HP:0003021)1.79954450
97Abnormality of T cell number (HP:0011839)1.77489438
98Pulmonary embolism (HP:0002204)1.77346262
99Epistaxis (HP:0000421)1.75485702
100Periodontitis (HP:0000704)1.75243468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.80334816
2MAP4K13.60783568
3RIPK43.47682888
4TYK23.35968798
5BLK3.32376443
6PRPF4B2.79510062
7MST1R2.65920626
8MAP3K102.57098298
9FGFR42.48548539
10RIPK12.33392854
11JAK11.88303709
12EPHB11.88190576
13EPHA31.86949987
14GRK61.83931195
15CDC42BPA1.81204578
16JAK31.74346172
17IKBKE1.73302049
18KIT1.69751750
19CSK1.68879950
20IRAK41.66925099
21ZAP701.62208802
22FES1.61968849
23TBK11.56180339
24FGFR31.47205084
25MAP3K141.44646110
26SYK1.37892668
27MAP3K11.36974925
28TRIB31.30690417
29LYN1.26875951
30SIK31.25436097
31BTK1.22920779
32CSF1R1.21778464
33BMPR21.17902637
34JAK21.12509345
35TAOK11.08285982
36MAP3K31.05150696
37TXK1.04750813
38PIK3CA1.04364989
39TGFBR21.03784630
40ACVR1B1.00425744
41MATK0.99350495
42HCK0.98839518
43MAP3K130.96482477
44SMG10.92490730
45PTK60.91569221
46NLK0.90879023
47FGR0.89847198
48EPHA20.89522122
49IRAK10.85412947
50HIPK20.83805239
51MAP2K30.83719281
52YES10.83672106
53STK240.82739091
54FER0.82700225
55PDGFRA0.80614577
56PRKG20.79669574
57LCK0.79388459
58LRRK20.79290836
59MET0.78300922
60IKBKB0.76296124
61MAPK70.76038976
62EPHB20.70245285
63PRKD20.68999958
64PKN20.68188409
65PDPK10.68036974
66TNK20.67658168
67DDR20.67143583
68FYN0.64294281
69MYLK0.61901255
70MAP3K110.60073894
71RET0.59386399
72TESK20.59013524
73MAP3K60.55332002
74PDK10.54297902
75ITK0.53652983
76MAP2K20.49896472
77MAPK110.49850025
78SIK10.49805483
79MAP3K20.49779844
80MAPKAPK20.48486762
81TGFBR10.45514748
82MARK20.45346936
83IRAK30.44002613
84TEC0.43221479
85KSR20.42791950
86PRKCQ0.41652339
87TESK10.40805156
88DYRK1B0.40597113
89PAK40.40063637
90LMTK20.39002754
91MAPK40.38615637
92MAPK120.38570838
93CDK60.38452811
94BMX0.38136242
95DMPK0.36077301
96PDGFRB0.35644424
97PRKCD0.34161990
98TAOK20.32742785
99MAP2K60.30996562
100ABL10.30863508

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.06041424
2Asthma_Homo sapiens_hsa053103.80229884
3Allograft rejection_Homo sapiens_hsa053303.54178159
4Autoimmune thyroid disease_Homo sapiens_hsa053203.37981597
5Graft-versus-host disease_Homo sapiens_hsa053323.26631508
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.14804691
7Leishmaniasis_Homo sapiens_hsa051402.77837193
8Type I diabetes mellitus_Homo sapiens_hsa049402.68115108
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50953529
10Antigen processing and presentation_Homo sapiens_hsa046122.34616477
11Viral myocarditis_Homo sapiens_hsa054162.09201280
12Primary immunodeficiency_Homo sapiens_hsa053402.01325454
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.85267914
14Toxoplasmosis_Homo sapiens_hsa051451.71735008
15B cell receptor signaling pathway_Homo sapiens_hsa046621.71377733
16Pertussis_Homo sapiens_hsa051331.67552457
17Osteoclast differentiation_Homo sapiens_hsa043801.62972465
18Hematopoietic cell lineage_Homo sapiens_hsa046401.60907683
19Tuberculosis_Homo sapiens_hsa051521.59503348
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57615787
21Influenza A_Homo sapiens_hsa051641.46277687
22Rheumatoid arthritis_Homo sapiens_hsa053231.44846582
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.35805178
24Other glycan degradation_Homo sapiens_hsa005111.32294538
25Herpes simplex infection_Homo sapiens_hsa051681.24395238
26Phagosome_Homo sapiens_hsa041451.21814826
27Complement and coagulation cascades_Homo sapiens_hsa046101.20699026
28Malaria_Homo sapiens_hsa051441.15800555
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13907646
30Chemokine signaling pathway_Homo sapiens_hsa040621.13124433
31Renin-angiotensin system_Homo sapiens_hsa046141.09258237
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03079383
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00761008
34TNF signaling pathway_Homo sapiens_hsa046681.00383347
35Fat digestion and absorption_Homo sapiens_hsa049750.98670171
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.97534968
37Hepatitis C_Homo sapiens_hsa051600.96120334
38Sulfur metabolism_Homo sapiens_hsa009200.95738956
39Measles_Homo sapiens_hsa051620.95435848
40Arginine biosynthesis_Homo sapiens_hsa002200.91954268
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91942562
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88276640
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87137856
44African trypanosomiasis_Homo sapiens_hsa051430.86244520
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.82813773
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80031524
47Fructose and mannose metabolism_Homo sapiens_hsa000510.79408732
48Protein digestion and absorption_Homo sapiens_hsa049740.74358964
49Acute myeloid leukemia_Homo sapiens_hsa052210.73152144
50Mineral absorption_Homo sapiens_hsa049780.71854659
51Systemic lupus erythematosus_Homo sapiens_hsa053220.70905056
52Arachidonic acid metabolism_Homo sapiens_hsa005900.70546296
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68185494
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67753363
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64877322
56Amoebiasis_Homo sapiens_hsa051460.64334851
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60987681
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59961335
59T cell receptor signaling pathway_Homo sapiens_hsa046600.59459955
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59336877
61Lysosome_Homo sapiens_hsa041420.59029686
62Histidine metabolism_Homo sapiens_hsa003400.57784266
63Apoptosis_Homo sapiens_hsa042100.53860913
64Hepatitis B_Homo sapiens_hsa051610.52554376
65Pancreatic secretion_Homo sapiens_hsa049720.51326941
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49646405
67Salmonella infection_Homo sapiens_hsa051320.48188885
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47074695
69HTLV-I infection_Homo sapiens_hsa051660.46596645
70Linoleic acid metabolism_Homo sapiens_hsa005910.44079121
71Epstein-Barr virus infection_Homo sapiens_hsa051690.43630607
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42859024
73Platelet activation_Homo sapiens_hsa046110.42070914
74Caffeine metabolism_Homo sapiens_hsa002320.41914452
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.41435687
76Prion diseases_Homo sapiens_hsa050200.41289858
77Galactose metabolism_Homo sapiens_hsa000520.40999573
78Pancreatic cancer_Homo sapiens_hsa052120.39756430
79Legionellosis_Homo sapiens_hsa051340.38364551
80Notch signaling pathway_Homo sapiens_hsa043300.35279784
81Starch and sucrose metabolism_Homo sapiens_hsa005000.35162875
82Prolactin signaling pathway_Homo sapiens_hsa049170.34913854
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34744800
84Vitamin digestion and absorption_Homo sapiens_hsa049770.34225951
85PPAR signaling pathway_Homo sapiens_hsa033200.33295259
86GnRH signaling pathway_Homo sapiens_hsa049120.33288647
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31461730
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30867426
89VEGF signaling pathway_Homo sapiens_hsa043700.30663377
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30607716
91Chronic myeloid leukemia_Homo sapiens_hsa052200.30546738
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30492531
93Renal cell carcinoma_Homo sapiens_hsa052110.28620992
94Endocytosis_Homo sapiens_hsa041440.28198276
95HIF-1 signaling pathway_Homo sapiens_hsa040660.27620539
96Ether lipid metabolism_Homo sapiens_hsa005650.27616030
97Shigellosis_Homo sapiens_hsa051310.26565682
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25552528
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.24446527
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23513541

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