IGLV2-14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, classical pathway (GO:0006958)9.80120535
2complement activation (GO:0006956)7.62861947
3positive regulation of respiratory burst (GO:0060267)7.01629569
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.80590658
5glomerular filtration (GO:0003094)5.75793134
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.70640963
7regulation of glucose import in response to insulin stimulus (GO:2001273)5.67019089
8protein activation cascade (GO:0072376)5.53978528
9antigen processing and presentation of endogenous antigen (GO:0019883)5.32590847
10renal filtration (GO:0097205)5.19483894
11Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.91813470
12immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.91813470
13Fc-gamma receptor signaling pathway (GO:0038094)4.91813470
14Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.88072594
15regulation of respiratory burst (GO:0060263)4.78379239
16humoral immune response (GO:0006959)4.66290904
17antibacterial humoral response (GO:0019731)4.54676188
18antimicrobial humoral response (GO:0019730)4.53160016
19regulation of cellular extravasation (GO:0002691)4.36657535
20T cell migration (GO:0072678)4.25116645
21COPI coating of Golgi vesicle (GO:0048205)3.84533990
22Golgi transport vesicle coating (GO:0048200)3.84533990
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65914546
24virion attachment to host cell (GO:0019062)3.62379655
25adhesion of symbiont to host cell (GO:0044650)3.62379655
26apoptotic cell clearance (GO:0043277)3.56646131
27adhesion of symbiont to host (GO:0044406)3.51621246
28leukocyte tethering or rolling (GO:0050901)3.42778001
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40780323
30detection of bacterium (GO:0016045)3.33156699
31germinal center formation (GO:0002467)3.29894324
32GDP-mannose metabolic process (GO:0019673)3.27972300
33retina homeostasis (GO:0001895)3.25207772
34detection of other organism (GO:0098543)3.22815528
35regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.21709460
36immune response-activating cell surface receptor signaling pathway (GO:0002429)3.20471142
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17189525
38lymphocyte migration (GO:0072676)3.11380501
39mannose metabolic process (GO:0006013)3.08098936
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03941048
41positive regulation of gamma-delta T cell activation (GO:0046645)2.99326770
42peptide catabolic process (GO:0043171)2.97947045
43angiotensin maturation (GO:0002003)2.96434362
44mitochondrion distribution (GO:0048311)2.94928498
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90537726
46negative regulation of cell killing (GO:0031342)2.90537726
47interferon-gamma-mediated signaling pathway (GO:0060333)2.86251214
48production of molecular mediator of immune response (GO:0002440)2.85923418
49cellular response to type I interferon (GO:0071357)2.85520090
50type I interferon signaling pathway (GO:0060337)2.85520090
51response to type I interferon (GO:0034340)2.84999110
52regulation of necrotic cell death (GO:0010939)2.84846912
53ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.84763282
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84704658
55immunoglobulin mediated immune response (GO:0016064)2.83972892
56regulation of antigen processing and presentation (GO:0002577)2.83900028
57NIK/NF-kappaB signaling (GO:0038061)2.82835549
58negative regulation of myotube differentiation (GO:0010832)2.82428828
59negative regulation of glucose import (GO:0046325)2.82337353
60antigen processing and presentation via MHC class Ib (GO:0002475)2.82266307
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.80756406
62positive regulation of nuclease activity (GO:0032075)2.80207342
63positive regulation of antigen processing and presentation (GO:0002579)2.79908808
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78243235
65regulation of integrin activation (GO:0033623)2.76256393
66endoplasmic reticulum unfolded protein response (GO:0030968)2.75981206
67mitochondrial calcium ion transport (GO:0006851)2.74701375
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71015247
69maintenance of gastrointestinal epithelium (GO:0030277)2.70554713
70NADH metabolic process (GO:0006734)2.67085377
71protein retention in ER lumen (GO:0006621)2.64176625
72dendritic cell chemotaxis (GO:0002407)2.59322304
73cellular response to unfolded protein (GO:0034620)2.58556421
74regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58155737
75regulation of nuclease activity (GO:0032069)2.57675843
76regulation of interferon-beta biosynthetic process (GO:0045357)2.55671895
77ER-nucleus signaling pathway (GO:0006984)2.53550275
78B cell homeostasis (GO:0001782)2.53344219
79negative T cell selection (GO:0043383)2.53167574
80immune response-activating signal transduction (GO:0002757)2.52896078
81detection of external biotic stimulus (GO:0098581)2.52588857
82B cell receptor signaling pathway (GO:0050853)2.52035847
83response to endoplasmic reticulum stress (GO:0034976)2.50857760
84regulation of necroptotic process (GO:0060544)2.50732337
85negative thymic T cell selection (GO:0045060)2.50035113
86respiratory burst (GO:0045730)2.49940165
87intestinal absorption (GO:0050892)2.49662430
88cellular response to interferon-gamma (GO:0071346)2.48263822
89myeloid dendritic cell differentiation (GO:0043011)2.47327376
90activation of immune response (GO:0002253)2.43856496
91thymic T cell selection (GO:0045061)2.41497317
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41138177
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.41138177
94modulation by symbiont of host immune response (GO:0052553)2.41138177
95positive regulation by symbiont of host defense response (GO:0052509)2.41138177
96modulation by symbiont of host defense response (GO:0052031)2.41138177
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41138177
98positive regulation of immunoglobulin production (GO:0002639)2.40713624
99response to interferon-gamma (GO:0034341)2.38050018
100mature B cell differentiation involved in immune response (GO:0002313)2.37617958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.74244921
2MYC_22102868_ChIP-Seq_BL_Human3.58985498
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.41125039
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21874895
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.84069379
6VDR_21846776_ChIP-Seq_THP-1_Human2.63885282
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62487033
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60269907
9LXR_22292898_ChIP-Seq_THP-1_Human2.53444225
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53354766
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49948634
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.45480897
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.26085183
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97582609
15STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97490890
16VDR_24763502_ChIP-Seq_THP-1_Human1.96597463
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91009415
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86929172
19MAF_26560356_Chip-Seq_TH1_Human1.86839484
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86567500
21TCF7_22412390_ChIP-Seq_EML_Mouse1.84097353
22CLOCK_20551151_ChIP-Seq_293T_Human1.83305644
23UTX_26944678_Chip-Seq_JUKART_Human1.79949001
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79932172
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78569276
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78003420
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.73754377
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70202632
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.69796067
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68730877
31MYB_26560356_Chip-Seq_TH2_Human1.67522036
32RACK7_27058665_Chip-Seq_MCF-7_Human1.67166443
33E2F7_22180533_ChIP-Seq_HELA_Human1.63983651
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63485713
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63177682
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.60320267
37MYB_26560356_Chip-Seq_TH1_Human1.59504686
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.58335397
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.56711840
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56345793
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55283667
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54810338
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53586769
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52362694
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44993736
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44722985
47MAF_26560356_Chip-Seq_TH2_Human1.42617603
48KDM2B_26808549_Chip-Seq_DND41_Human1.41892732
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40237797
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39969070
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39488429
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39185210
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38570880
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36396491
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.34681300
56NCOR1_26117541_ChIP-Seq_K562_Human1.32320133
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32301126
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.30157492
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27298387
60SPI1_23547873_ChIP-Seq_NB4_Human1.25987290
61RUNX_20019798_ChIP-Seq_JUKART_Human1.25732913
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25325709
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25172997
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24972685
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24806427
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21840275
67SCL_19346495_ChIP-Seq_HPC-7_Human1.21080291
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19890631
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19678360
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19597951
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19483540
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17464418
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16672895
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16246065
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16131062
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12944595
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.12641443
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11741413
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11576704
80SPI1_23127762_ChIP-Seq_K562_Human1.09557047
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08895165
82GATA1_19941826_ChIP-Seq_K562_Human1.07584112
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07521056
84ETS1_21867929_ChIP-Seq_TH2_Mouse1.07206377
85BCOR_27268052_Chip-Seq_Bcells_Human1.07124353
86BCL6_27268052_Chip-Seq_Bcells_Human1.06879848
87SMC4_20622854_ChIP-Seq_HELA_Human1.06742742
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.06288782
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06224494
90EGR1_19032775_ChIP-ChIP_M12_Human1.04789830
91P68_20966046_ChIP-Seq_HELA_Human1.04392494
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03813289
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02238111
94CIITA_25753668_ChIP-Seq_RAJI_Human1.01671306
95GATA6_25053715_ChIP-Seq_YYC3_Human1.01375173
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00306007
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99323249
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99157341
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.98982064
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97165757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.47270098
2MP0000685_abnormal_immune_system3.77833022
3MP0001835_abnormal_antigen_presentation3.52927178
4MP0003303_peritoneal_inflammation3.31511568
5MP0005387_immune_system_phenotype2.88590241
6MP0001790_abnormal_immune_system2.88590241
7MP0010155_abnormal_intestine_physiology2.82738649
8MP0003724_increased_susceptibility_to2.72279834
9MP0003436_decreased_susceptibility_to2.62403340
10MP0004264_abnormal_extraembryonic_tissu2.55923710
11MP0005025_abnormal_response_to2.33522721
12MP0001800_abnormal_humoral_immune2.29135170
13MP0003300_gastrointestinal_ulcer2.26978801
14MP0008438_abnormal_cutaneous_collagen2.26962913
15MP0005671_abnormal_response_to2.16883162
16MP0009333_abnormal_splenocyte_physiolog2.15803968
17MP0003763_abnormal_thymus_physiology2.08723376
18MP0005000_abnormal_immune_tolerance2.05089797
19MP0002166_altered_tumor_susceptibility2.02768223
20MP0002396_abnormal_hematopoietic_system2.00939203
21MP0004043_abnormal_pH_regulation1.94899386
22MP0003866_abnormal_defecation1.86155468
23MP0002148_abnormal_hypersensitivity_rea1.83251973
24MP0002452_abnormal_antigen_presenting1.82299247
25MP0004782_abnormal_surfactant_physiolog1.81708483
26MP0009785_altered_susceptibility_to1.79771918
27MP0002420_abnormal_adaptive_immunity1.79134514
28MP0001819_abnormal_immune_cell1.78846952
29MP0002723_abnormal_immune_serum1.78449470
30MP0004858_abnormal_nervous_system1.76618919
31MP0005166_decreased_susceptibility_to1.75718032
32MP0004947_skin_inflammation1.72556485
33MP0009840_abnormal_foam_cell1.71312333
34MP0005451_abnormal_body_composition1.65205320
35MP0001873_stomach_inflammation1.64922391
36MP0002139_abnormal_hepatobiliary_system1.64525523
37MP0001845_abnormal_inflammatory_respons1.62678163
38MP0002419_abnormal_innate_immunity1.58485833
39MP0000465_gastrointestinal_hemorrhage1.52813533
40MP0002796_impaired_skin_barrier1.52531748
41MP0002933_joint_inflammation1.51794728
42MP0005058_abnormal_lysosome_morphology1.48074833
43MP0002398_abnormal_bone_marrow1.46700659
44MP0001663_abnormal_digestive_system1.46185649
45MP0000716_abnormal_immune_system1.45904847
46MP0005360_urolithiasis1.45825381
47MP0008004_abnormal_stomach_pH1.43450425
48MP0001533_abnormal_skeleton_physiology1.42599999
49MP0003183_abnormal_peptide_metabolism1.41208831
50MP0000490_abnormal_crypts_of1.39674261
51MP0000858_altered_metastatic_potential1.39392345
52MP0005310_abnormal_salivary_gland1.37636825
53MP0010352_gastrointestinal_tract_polyps1.36177421
54MP0002006_tumorigenesis1.33095841
55MP0003191_abnormal_cellular_cholesterol1.31511312
56MP0002429_abnormal_blood_cell1.23656705
57MP0005275_abnormal_skin_tensile1.22528325
58MP0002877_abnormal_melanocyte_morpholog1.21204027
59MP0005464_abnormal_platelet_physiology1.20842944
60MP0002138_abnormal_hepatobiliary_system1.19531132
61MP0008260_abnormal_autophagy1.17150906
62MP0000477_abnormal_intestine_morphology1.13189020
63MP0003453_abnormal_keratinocyte_physiol1.11897405
64MP0005381_digestive/alimentary_phenotyp1.11825306
65MP0006082_CNS_inflammation1.11655084
66MP0002722_abnormal_immune_system1.11616646
67MP0002405_respiratory_system_inflammati1.11212976
68MP0005023_abnormal_wound_healing1.09064204
69MP0003075_altered_response_to1.07334250
70MP0001666_abnormal_nutrient_absorption1.07100113
71MP0003448_altered_tumor_morphology0.99737515
72MP0003329_amyloid_beta_deposits0.97095991
73MP0005409_darkened_coat_color0.95913845
74MP0002098_abnormal_vibrissa_morphology0.95896947
75MP0000689_abnormal_spleen_morphology0.94660830
76MP0003045_fibrosis0.93982740
77MP0002009_preneoplasia0.91666407
78MP0000343_altered_response_to0.90235868
79MP0009643_abnormal_urine_homeostasis0.88763959
80MP0001664_abnormal_digestion0.87726662
81MP0000678_abnormal_parathyroid_gland0.87387523
82MP0000604_amyloidosis0.85804787
83MP0003705_abnormal_hypodermis_morpholog0.85590143
84MP0002998_abnormal_bone_remodeling0.84601792
85MP0001853_heart_inflammation0.84435984
86MP0000681_abnormal_thyroid_gland0.83789595
87MP0000703_abnormal_thymus_morphology0.82639717
88MP0008469_abnormal_protein_level0.81391110
89MP0009278_abnormal_bone_marrow0.80065107
90MP0002060_abnormal_skin_morphology0.79499924
91MP0001765_abnormal_ion_homeostasis0.77308321
92MP0003868_abnormal_feces_composition0.72042230
93MP0002136_abnormal_kidney_physiology0.70177493
94MP0001216_abnormal_epidermal_layer0.68063879
95MP0005501_abnormal_skin_physiology0.67857908
96MP0010307_abnormal_tumor_latency0.67835117
97MP0001849_ear_inflammation0.67346842
98MP0003795_abnormal_bone_structure0.66843982
99MP0005085_abnormal_gallbladder_physiolo0.65758295
100MP0009931_abnormal_skin_appearance0.65376787

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.43058463
2Decreased circulating renin level (HP:0003351)4.78144512
3Systemic lupus erythematosus (HP:0002725)4.59942677
4Malnutrition (HP:0004395)3.97606371
5Eczematoid dermatitis (HP:0000976)3.93111680
6Gastrointestinal stroma tumor (HP:0100723)3.54968406
7Abnormality of macrophages (HP:0004311)3.52631677
8Increased IgE level (HP:0003212)3.36524361
9Recurrent bronchitis (HP:0002837)3.27222250
10Nuclear cataract (HP:0100018)3.24518124
11Abnormality of complement system (HP:0005339)3.22949580
12Premature loss of primary teeth (HP:0006323)3.18765741
13Vasculitis (HP:0002633)3.18335954
14Alkalosis (HP:0001948)3.08887136
15Colitis (HP:0002583)3.04780823
16Abnormality of renin-angiotensin system (HP:0000847)2.98203138
17Abnormality of cells of the lymphoid lineage (HP:0012140)2.97107746
18Prostate neoplasm (HP:0100787)2.95576000
19Meningitis (HP:0001287)2.93006155
20Spontaneous hematomas (HP:0007420)2.89329250
21Agammaglobulinemia (HP:0004432)2.85958191
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.83905606
23Urticaria (HP:0001025)2.82605617
24Chronic diarrhea (HP:0002028)2.82592468
25Cellulitis (HP:0100658)2.82029019
26Gastrointestinal inflammation (HP:0004386)2.77192913
27Emphysema (HP:0002097)2.76714084
28Glomerulonephritis (HP:0000099)2.75742632
29Complement deficiency (HP:0004431)2.75078169
30Hyperkalemia (HP:0002153)2.73353769
31Inflammation of the large intestine (HP:0002037)2.72774291
32Abnormality of B cell number (HP:0010975)2.71747770
33Recurrent viral infections (HP:0004429)2.71031531
34Abnormality of small intestinal villus morphology (HP:0011472)2.70803699
35Villous atrophy (HP:0011473)2.70803699
36Bronchitis (HP:0012387)2.70253519
37IgM deficiency (HP:0002850)2.65860427
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63469420
39Hypokalemic alkalosis (HP:0001949)2.56013753
40Skin rash (HP:0000988)2.54005752
41Recurrent bacterial skin infections (HP:0005406)2.51620587
42Osteomyelitis (HP:0002754)2.50453012
43Nephritis (HP:0000123)2.49877509
44Zonular cataract (HP:0010920)2.49874586
45Abnormality of chloride homeostasis (HP:0011422)2.48902498
46Abnormality of T cell physiology (HP:0011840)2.43819700
47Recurrent abscess formation (HP:0002722)2.41303082
48J-shaped sella turcica (HP:0002680)2.36996966
49Chronic obstructive pulmonary disease (HP:0006510)2.34854875
50Obstructive lung disease (HP:0006536)2.34854875
51Hyperaldosteronism (HP:0000859)2.34779154
52Flat acetabular roof (HP:0003180)2.27517621
53Hyponatremia (HP:0002902)2.23750864
54Right ventricular cardiomyopathy (HP:0011663)2.23575536
55Ankyloglossia (HP:0010296)2.22920056
56Abnormality of the prostate (HP:0008775)2.21887030
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21593283
58Abnormality of the nasal mucosa (HP:0000433)2.21592321
59IgA deficiency (HP:0002720)2.20391391
60Recurrent pneumonia (HP:0006532)2.20374274
61Abnormal gallbladder physiology (HP:0012438)2.17835016
62Cholecystitis (HP:0001082)2.17835016
63Hemorrhage of the eye (HP:0011885)2.14390683
64Pustule (HP:0200039)2.14200576
65Mediastinal lymphadenopathy (HP:0100721)2.14031546
66Ileus (HP:0002595)2.13735115
67Gingivitis (HP:0000230)2.10657042
68Recurrent sinusitis (HP:0011108)2.08635002
69Gastrointestinal infarctions (HP:0005244)2.08081541
70Ridged nail (HP:0001807)2.06490135
71Papilloma (HP:0012740)2.06410252
72Verrucae (HP:0200043)2.06410252
73Lymphopenia (HP:0001888)2.02994207
74Recurrent lower respiratory tract infections (HP:0002783)2.00737080
75Hypotension (HP:0002615)2.00574017
76Renal salt wasting (HP:0000127)1.99836101
77Segmental peripheral demyelination/remyelination (HP:0003481)1.98266956
78Growth hormone excess (HP:0000845)1.95212155
79Rhabdomyolysis (HP:0003201)1.94826544
80Hypergammaglobulinemia (HP:0010702)1.94265182
81Abnormality of glycolipid metabolism (HP:0010969)1.93898767
82Abnormality of liposaccharide metabolism (HP:0010968)1.93898767
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.93898767
84Cerebral aneurysm (HP:0004944)1.90808442
85Abdominal distention (HP:0003270)1.90409860
86B lymphocytopenia (HP:0010976)1.89000534
87Autoimmune hemolytic anemia (HP:0001890)1.88475748
88Autoimmune thrombocytopenia (HP:0001973)1.87771527
89Chronic bronchitis (HP:0004469)1.87389911
90Recurrent gram-negative bacterial infections (HP:0005420)1.86831683
91Restrictive lung disease (HP:0002091)1.85801392
92Esophageal neoplasm (HP:0100751)1.83856206
93Neoplasm of head and neck (HP:0012288)1.83856206
94Metaphyseal cupping (HP:0003021)1.82998113
95Polycythemia (HP:0001901)1.81874514
96Orchitis (HP:0100796)1.81491090
97Sepsis (HP:0100806)1.80965206
98Onycholysis (HP:0001806)1.78742004
99Abnormality of T cells (HP:0002843)1.78271041
100Abnormality of sodium homeostasis (HP:0010931)1.77538037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.94293819
2PRPF4B4.51517221
3MAP3K103.41601142
4MAP4K12.89823310
5FGFR42.46966580
6IRAK32.37752779
7TYK22.35852511
8MST1R2.18698853
9SMG12.18665935
10PKN22.11504806
11TAOK32.10549569
12TRIB31.99104125
13RIPK11.80478455
14IRAK41.77925318
15RIPK41.67563860
16GRK61.59044893
17BLK1.57915607
18MAP3K131.51004619
19EEF2K1.41607132
20SIK11.40781623
21IKBKE1.38845097
22KSR21.35148987
23MAP3K11.30390434
24PTK21.27317640
25FGFR31.27273186
26TBK11.20148928
27JAK31.16930673
28CDC42BPA1.15680225
29MAP3K141.13541820
30STK241.11096599
31ZAP701.08401930
32JAK11.07312822
33LMTK21.01296681
34TESK20.99280806
35ITK0.97616988
36ICK0.96565954
37IRAK10.96409862
38JAK20.95487763
39MAPK110.94172588
40FES0.93869243
41SYK0.93678677
42IRAK20.89403920
43MAP3K30.89031461
44PDGFRA0.88830001
45BTK0.88609292
46PIK3CA0.85356819
47HCK0.83059822
48CDK60.82835784
49LYN0.82707908
50FLT30.81414411
51ARAF0.80253899
52EPHA30.77869989
53MAP2K30.76155586
54MAP3K20.75193878
55PDPK10.73261996
56SIK30.72005379
57PAK40.70432626
58PTK60.70058378
59EPHB10.69696399
60MAP2K60.68210459
61MET0.66017003
62PDK10.65342622
63HIPK20.65187024
64CDK120.65074292
65YES10.61988987
66MAP2K20.60173440
67TAOK20.58357462
68CDK40.58065087
69PRKG20.57560055
70TNK20.57273584
71TESK10.57250189
72MAPKAPK30.55626156
73RET0.55460348
74MAPK70.55289260
75MAPK120.55076044
76MAP3K80.53939714
77CSK0.52206122
78LRRK20.51051766
79MARK20.49275778
80TAOK10.48878904
81RAF10.47624518
82PDK20.47401953
83MAPKAPK20.47052394
84LCK0.46993310
85EIF2AK30.46752683
86CSF1R0.45715285
87MAPK40.44406018
88PRKD20.42357290
89SIK20.42161378
90NME20.42050278
91BRAF0.40504863
92RPS6KB20.40006020
93PIM20.38614540
94PIM10.38268946
95KIT0.37979526
96IKBKB0.37219073
97SCYL20.37040570
98STK40.36658617
99MAP3K110.34782958
100FYN0.33234057

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.14074721
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.03402823
3Staphylococcus aureus infection_Homo sapiens_hsa051502.97207449
4Allograft rejection_Homo sapiens_hsa053302.88859879
5Autoimmune thyroid disease_Homo sapiens_hsa053202.76139870
6Asthma_Homo sapiens_hsa053102.67155630
7Graft-versus-host disease_Homo sapiens_hsa053322.61450710
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47537605
9Antigen processing and presentation_Homo sapiens_hsa046122.14096052
10Type I diabetes mellitus_Homo sapiens_hsa049402.13427556
11Leishmaniasis_Homo sapiens_hsa051402.11543709
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06285593
13Fructose and mannose metabolism_Homo sapiens_hsa000512.03626846
14Arginine biosynthesis_Homo sapiens_hsa002201.98189168
15Primary immunodeficiency_Homo sapiens_hsa053401.95105923
16Viral myocarditis_Homo sapiens_hsa054161.78777587
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78129848
18Other glycan degradation_Homo sapiens_hsa005111.66555071
19N-Glycan biosynthesis_Homo sapiens_hsa005101.54434874
20B cell receptor signaling pathway_Homo sapiens_hsa046621.45630857
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40077287
22Influenza A_Homo sapiens_hsa051641.37394877
23Toxoplasmosis_Homo sapiens_hsa051451.35226908
24Pertussis_Homo sapiens_hsa051331.33602891
25Renin-angiotensin system_Homo sapiens_hsa046141.30388931
26Fat digestion and absorption_Homo sapiens_hsa049751.24979146
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24577724
28Acute myeloid leukemia_Homo sapiens_hsa052211.23216821
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22218552
30Tuberculosis_Homo sapiens_hsa051521.19238733
31Osteoclast differentiation_Homo sapiens_hsa043801.17390854
32Herpes simplex infection_Homo sapiens_hsa051681.13251569
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.08005450
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07606095
35Measles_Homo sapiens_hsa051621.00551470
36Galactose metabolism_Homo sapiens_hsa000521.00492950
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99487647
38Hematopoietic cell lineage_Homo sapiens_hsa046400.92370597
39Prion diseases_Homo sapiens_hsa050200.92171762
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91296877
41Chemokine signaling pathway_Homo sapiens_hsa040620.91266511
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90075406
43Non-small cell lung cancer_Homo sapiens_hsa052230.87184359
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83620505
45Sulfur metabolism_Homo sapiens_hsa009200.82637800
46Rheumatoid arthritis_Homo sapiens_hsa053230.81589435
47Hepatitis C_Homo sapiens_hsa051600.81402707
48Pentose phosphate pathway_Homo sapiens_hsa000300.79835235
49HIF-1 signaling pathway_Homo sapiens_hsa040660.78038106
50Chronic myeloid leukemia_Homo sapiens_hsa052200.77250381
51Phagosome_Homo sapiens_hsa041450.75974590
52Apoptosis_Homo sapiens_hsa042100.75874465
53Hepatitis B_Homo sapiens_hsa051610.72776158
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.72123817
55TNF signaling pathway_Homo sapiens_hsa046680.71499793
56Mineral absorption_Homo sapiens_hsa049780.69002625
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68484339
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66001863
59Pancreatic secretion_Homo sapiens_hsa049720.65994271
60Biosynthesis of amino acids_Homo sapiens_hsa012300.65354583
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64195242
62Vibrio cholerae infection_Homo sapiens_hsa051100.63377936
63Thyroid hormone synthesis_Homo sapiens_hsa049180.63030480
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.62088530
65Complement and coagulation cascades_Homo sapiens_hsa046100.61815734
66T cell receptor signaling pathway_Homo sapiens_hsa046600.61537615
67Vitamin digestion and absorption_Homo sapiens_hsa049770.60009455
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58712989
69Bladder cancer_Homo sapiens_hsa052190.57787913
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57551286
71Epstein-Barr virus infection_Homo sapiens_hsa051690.56852661
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.56604163
73Arginine and proline metabolism_Homo sapiens_hsa003300.56179260
74Protein digestion and absorption_Homo sapiens_hsa049740.56046338
75HTLV-I infection_Homo sapiens_hsa051660.55843841
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55113309
77VEGF signaling pathway_Homo sapiens_hsa043700.54877151
78Pancreatic cancer_Homo sapiens_hsa052120.53999786
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53484754
80Starch and sucrose metabolism_Homo sapiens_hsa005000.53263419
81African trypanosomiasis_Homo sapiens_hsa051430.49828633
82Malaria_Homo sapiens_hsa051440.49670990
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.48564835
84Arachidonic acid metabolism_Homo sapiens_hsa005900.47530209
85GnRH signaling pathway_Homo sapiens_hsa049120.47347369
86Legionellosis_Homo sapiens_hsa051340.45735533
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.42101628
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40936209
89Carbon metabolism_Homo sapiens_hsa012000.39938154
90Bile secretion_Homo sapiens_hsa049760.39282868
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39092153
92Lysosome_Homo sapiens_hsa041420.38432242
93Prolactin signaling pathway_Homo sapiens_hsa049170.37897097
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.33758685
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33256567
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32772292
97Thyroid cancer_Homo sapiens_hsa052160.32116003
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32095088
99Amoebiasis_Homo sapiens_hsa051460.31867881
100Caffeine metabolism_Homo sapiens_hsa002320.31334488

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