IGSF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.65357817
2central nervous system myelination (GO:0022010)5.65357817
3L-amino acid import (GO:0043092)4.24318192
4presynaptic membrane assembly (GO:0097105)4.13480847
5C4-dicarboxylate transport (GO:0015740)3.96638515
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93972564
7import into cell (GO:0098657)3.87365605
8retinal cone cell development (GO:0046549)3.81958236
9neuron cell-cell adhesion (GO:0007158)3.76907609
10presynaptic membrane organization (GO:0097090)3.75474912
11locomotory exploration behavior (GO:0035641)3.75130023
12potassium ion import (GO:0010107)3.70480590
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66516710
14postsynaptic membrane organization (GO:0001941)3.61719110
15positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.60612003
16synaptic vesicle maturation (GO:0016188)3.55515050
17negative regulation of synaptic transmission, GABAergic (GO:0032229)3.54741733
18fatty acid elongation (GO:0030497)3.53370755
19amino acid import (GO:0043090)3.41875619
20heparin metabolic process (GO:0030202)3.34114708
21heparin biosynthetic process (GO:0030210)3.34114708
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.21095408
23eye photoreceptor cell differentiation (GO:0001754)3.20948876
24photoreceptor cell differentiation (GO:0046530)3.20948876
25righting reflex (GO:0060013)3.19182891
26myelination (GO:0042552)3.16124756
27gonadal mesoderm development (GO:0007506)3.16065822
28negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14059107
29acidic amino acid transport (GO:0015800)3.13516200
30axonal fasciculation (GO:0007413)3.12274455
31limb bud formation (GO:0060174)3.11112449
32cerebral cortex radially oriented cell migration (GO:0021799)3.10667624
33axon ensheathment (GO:0008366)3.10158317
34ensheathment of neurons (GO:0007272)3.10158317
35synaptic vesicle exocytosis (GO:0016079)3.08580491
36long-chain fatty acid biosynthetic process (GO:0042759)3.07457786
37retina layer formation (GO:0010842)3.06606279
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.05459416
39cellular potassium ion homeostasis (GO:0030007)3.04984363
40neuronal action potential propagation (GO:0019227)3.03558455
41regulation of inositol phosphate biosynthetic process (GO:0010919)2.95516202
42vocalization behavior (GO:0071625)2.94054870
43regulation of short-term neuronal synaptic plasticity (GO:0048172)2.92576658
44melanin biosynthetic process (GO:0042438)2.91827621
45glutamate secretion (GO:0014047)2.90529897
46negative regulation of neurotransmitter transport (GO:0051589)2.89873431
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88518485
48regulation of synaptic vesicle exocytosis (GO:2000300)2.88232026
49transmission of nerve impulse (GO:0019226)2.87420819
50L-glutamate transport (GO:0015813)2.86348873
51exploration behavior (GO:0035640)2.86308995
52oligodendrocyte differentiation (GO:0048709)2.82953431
53glutamate receptor signaling pathway (GO:0007215)2.81698010
54sodium ion export (GO:0071436)2.81418327
55astrocyte differentiation (GO:0048708)2.81404647
56glycosphingolipid biosynthetic process (GO:0006688)2.76437672
57positive regulation of meiosis (GO:0045836)2.75731797
58negative regulation of neurotransmitter secretion (GO:0046929)2.74520465
59gamma-aminobutyric acid transport (GO:0015812)2.74087319
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74061044
61regulation of timing of cell differentiation (GO:0048505)2.73438097
62neuron remodeling (GO:0016322)2.71217421
63positive regulation of cellular amine metabolic process (GO:0033240)2.69942017
64regulation of neuronal synaptic plasticity (GO:0048168)2.69619357
65piRNA metabolic process (GO:0034587)2.69009775
66response to methylmercury (GO:0051597)2.68335787
67proline transport (GO:0015824)2.67843731
68protein localization to synapse (GO:0035418)2.67449325
69negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.67413791
70protein polyglutamylation (GO:0018095)2.65554847
71glycerophospholipid catabolic process (GO:0046475)2.65066939
72regulation of synaptic vesicle transport (GO:1902803)2.64845604
73dermatan sulfate biosynthetic process (GO:0030208)2.64528728
74regulation of neurotransmitter uptake (GO:0051580)2.64023193
75potassium ion homeostasis (GO:0055075)2.59825551
76melanin metabolic process (GO:0006582)2.59032780
77secondary metabolite biosynthetic process (GO:0044550)2.58416847
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57621612
79short-term memory (GO:0007614)2.56594077
80photoreceptor cell maintenance (GO:0045494)2.55908809
81cellular response to epinephrine stimulus (GO:0071872)2.55346514
82positive regulation of meiotic cell cycle (GO:0051446)2.54968205
83response to epinephrine (GO:0071871)2.52863768
84startle response (GO:0001964)2.51947886
85calcium ion-dependent exocytosis (GO:0017156)2.51743585
86neuron recognition (GO:0008038)2.51669913
87cochlea development (GO:0090102)2.50416165
88neurotransmitter secretion (GO:0007269)2.50072076
89reflex (GO:0060004)2.48997242
90cranial nerve morphogenesis (GO:0021602)2.48326574
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.48320805
92regulation of meiosis I (GO:0060631)2.48053460
93dendritic spine morphogenesis (GO:0060997)2.47183394
94negative regulation of protein localization to cell surface (GO:2000009)2.46588859
95auditory behavior (GO:0031223)2.46362593
96positive regulation of protein kinase C signaling (GO:0090037)2.45735477
97polyol transport (GO:0015791)2.45692185
98pyrimidine nucleobase catabolic process (GO:0006208)2.45267841
99chemosensory behavior (GO:0007635)2.44017934
100central nervous system projection neuron axonogenesis (GO:0021952)2.43838939
101cranial nerve development (GO:0021545)2.43156317
102acrosome reaction (GO:0007340)2.42443491
103dermatan sulfate metabolic process (GO:0030205)2.42360865
104alanine transport (GO:0032328)2.41711022
105regulation of pigment cell differentiation (GO:0050932)2.41613214
106peripheral nervous system development (GO:0007422)2.40739943
107membrane depolarization during action potential (GO:0086010)2.40321150
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.40125046
109translesion synthesis (GO:0019985)2.39294600
110positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39233092
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.39044400
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.38540680
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.37894110
114establishment of nucleus localization (GO:0040023)2.37349369
115positive regulation of action potential (GO:0045760)2.37194333
116phosphorelay signal transduction system (GO:0000160)2.36708941
117tongue development (GO:0043586)2.36507038
118DNA methylation involved in gamete generation (GO:0043046)2.36294879
119neurotransmitter transport (GO:0006836)2.36100174
120cerebral cortex neuron differentiation (GO:0021895)2.35888888
121mesenchymal cell differentiation involved in kidney development (GO:0072161)2.34477013
122mesenchymal cell differentiation involved in renal system development (GO:2001012)2.34477013
123peripheral nervous system axon ensheathment (GO:0032292)2.32789974
124myelination in peripheral nervous system (GO:0022011)2.32789974
125neuronal ion channel clustering (GO:0045161)2.31822082
126negative regulation of execution phase of apoptosis (GO:1900118)2.29635326
127organ growth (GO:0035265)2.29619554
128positive regulation of synapse assembly (GO:0051965)2.29577765
129neurotransmitter uptake (GO:0001504)2.29371174
130regulation of rhodopsin mediated signaling pathway (GO:0022400)2.29300011
131neurotransmitter-gated ion channel clustering (GO:0072578)2.27488292
132synaptic transmission, glutamatergic (GO:0035249)2.26198624
133response to auditory stimulus (GO:0010996)2.24531554
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.24255883
135regulation of glutamate receptor signaling pathway (GO:1900449)2.24159497
136regulation of collateral sprouting (GO:0048670)2.24083338
137rhodopsin mediated signaling pathway (GO:0016056)2.23522322
138mechanosensory behavior (GO:0007638)2.22419687
139cyclic nucleotide catabolic process (GO:0009214)2.21137326
140negative regulation of astrocyte differentiation (GO:0048712)2.20999485
141adult walking behavior (GO:0007628)2.19614320
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.18454314
143neuron-neuron synaptic transmission (GO:0007270)2.18418874
144positive regulation of alcohol biosynthetic process (GO:1902932)2.17876216
145calcium ion import (GO:0070509)2.16849621
146glucosamine-containing compound catabolic process (GO:1901072)2.15800038
147mating behavior (GO:0007617)2.15799472
148regulation of development, heterochronic (GO:0040034)2.15051897
149metanephric nephron tubule development (GO:0072234)2.14979975
150metanephric tubule development (GO:0072170)2.14979975
151positive regulation of dendritic spine development (GO:0060999)2.14759681
152regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.13999810
153cranial nerve structural organization (GO:0021604)2.13280252
154nonmotile primary cilium assembly (GO:0035058)2.12827059
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.12443429
156detection of light stimulus involved in sensory perception (GO:0050962)2.07002965
157detection of light stimulus involved in visual perception (GO:0050908)2.07002965
158cerebral cortex cell migration (GO:0021795)2.06767189
159positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.06237399
160nucleotide transmembrane transport (GO:1901679)2.05412625
161positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.04824205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92428486
2GBX2_23144817_ChIP-Seq_PC3_Human3.58345969
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63676105
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43580590
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36839252
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.28519307
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.28350385
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26853003
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25947016
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22797217
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16625992
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16536978
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16536978
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16228063
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15687560
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10063160
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08337106
18TAF15_26573619_Chip-Seq_HEK293_Human2.05554294
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04264378
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.93893952
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87429332
22AR_21572438_ChIP-Seq_LNCaP_Human1.84245399
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.83902094
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79301373
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78506196
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.78354685
27VDR_22108803_ChIP-Seq_LS180_Human1.77656002
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76679880
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75565139
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75073105
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73182389
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.68329131
33* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67373436
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.67139781
35* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65304069
36IGF1R_20145208_ChIP-Seq_DFB_Human1.65104991
37* P300_19829295_ChIP-Seq_ESCs_Human1.64434165
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60989324
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57271918
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56656719
41* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55198674
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51970175
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51016885
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50945989
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50651616
46ZNF274_21170338_ChIP-Seq_K562_Hela1.49827651
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.48968051
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47642070
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.47455305
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46638048
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.46402282
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.43853562
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.42524679
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41905742
55RNF2_27304074_Chip-Seq_NSC_Mouse1.41517720
56DROSHA_22980978_ChIP-Seq_HELA_Human1.40186613
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39060324
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38371648
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37637778
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.35807652
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35639571
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35210764
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35124421
64ER_23166858_ChIP-Seq_MCF-7_Human1.35015134
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.33302033
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31983371
67CBP_20019798_ChIP-Seq_JUKART_Human1.31438611
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31438611
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29940022
70P53_22387025_ChIP-Seq_ESCs_Mouse1.29858634
71* REST_21632747_ChIP-Seq_MESCs_Mouse1.28298519
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.27478554
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.26716987
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26639501
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25208497
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24633278
77* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23339673
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23226247
79BCAT_22108803_ChIP-Seq_LS180_Human1.20934380
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20844296
81P300_18555785_Chip-Seq_ESCs_Mouse1.20423491
82* STAT3_23295773_ChIP-Seq_U87_Human1.19414574
83TP53_18474530_ChIP-ChIP_U2OS_Human1.19351070
84FUS_26573619_Chip-Seq_HEK293_Human1.19145479
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.18432950
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17897224
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.17591035
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.15660895
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15571434
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15453518
91* SMAD3_21741376_ChIP-Seq_ESCs_Human1.15257362
92* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15218893
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14390401
94* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14309829
95* AR_19668381_ChIP-Seq_PC3_Human1.13270040
96RUNX2_22187159_ChIP-Seq_PCA_Human1.12312543
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.11858685
98SOX9_26525672_Chip-Seq_HEART_Mouse1.11181308
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.10394416
100* AR_25329375_ChIP-Seq_VCAP_Human1.10357067
101TCF4_22108803_ChIP-Seq_LS180_Human1.09756431
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.09681242
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09331663
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08840657
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.08724711
106KDM2B_26808549_Chip-Seq_REH_Human1.08715012
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.08693390
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08616225
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.08608431
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08486182
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08486182
112* TCF4_23295773_ChIP-Seq_U87_Human1.07859497
113* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07508814
114* EWS_26573619_Chip-Seq_HEK293_Human1.06908129
115PU1_27457419_Chip-Seq_LIVER_Mouse1.04265920
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.04227598
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04127914
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04026043
119AHR_22903824_ChIP-Seq_MCF-7_Human1.03866721
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03570824
121KLF4_18555785_Chip-Seq_ESCs_Mouse1.01569022
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01101867
123ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00671720
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98918318
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.98049757
126SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97501961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.74743715
2MP0003880_abnormal_central_pattern3.49439098
3MP0005409_darkened_coat_color2.84030603
4MP0001486_abnormal_startle_reflex2.69524040
5MP0002102_abnormal_ear_morphology2.55630442
6MP0004742_abnormal_vestibular_system2.52702187
7MP0000920_abnormal_myelination2.48781124
8MP0005551_abnormal_eye_electrophysiolog2.35161961
9MP0000566_synostosis2.33948905
10MP0000569_abnormal_digit_pigmentation2.32073661
11MP0005423_abnormal_somatic_nervous2.30417604
12MP0001188_hyperpigmentation2.24073516
13MP0006292_abnormal_olfactory_placode2.19836016
14MP0004381_abnormal_hair_follicle2.13320772
15MP0009745_abnormal_behavioral_response2.05696399
16MP0008877_abnormal_DNA_methylation2.02617216
17MP0003690_abnormal_glial_cell2.02188364
18MP0002272_abnormal_nervous_system2.00734056
19MP0004859_abnormal_synaptic_plasticity1.99730438
20MP0002822_catalepsy1.94404614
21MP0002064_seizures1.89287741
22MP0009046_muscle_twitch1.88312366
23MP0003635_abnormal_synaptic_transmissio1.87688783
24MP0005171_absent_coat_pigmentation1.87180071
25MP0004885_abnormal_endolymph1.82271093
26MP0005646_abnormal_pituitary_gland1.81487624
27MP0003011_delayed_dark_adaptation1.77039949
28MP0001968_abnormal_touch/_nociception1.72104904
29MP0003195_calcinosis1.68780592
30MP0004142_abnormal_muscle_tone1.67208251
31MP0004270_analgesia1.65164762
32MP0000372_irregular_coat_pigmentation1.64339936
33MP0002572_abnormal_emotion/affect_behav1.63434823
34MP0002067_abnormal_sensory_capabilities1.62066690
35MP0005248_abnormal_Harderian_gland1.60516486
36MP0008260_abnormal_autophagy1.58522632
37MP0000778_abnormal_nervous_system1.57268318
38MP0005408_hypopigmentation1.57227031
39MP0002876_abnormal_thyroid_physiology1.57219829
40MP0001440_abnormal_grooming_behavior1.56769398
41MP0002095_abnormal_skin_pigmentation1.55384518
42MP0001963_abnormal_hearing_physiology1.53883005
43MP0000026_abnormal_inner_ear1.52063142
44MP0005174_abnormal_tail_pigmentation1.51434198
45MP0005645_abnormal_hypothalamus_physiol1.49091018
46MP0001485_abnormal_pinna_reflex1.48244016
47MP0001986_abnormal_taste_sensitivity1.44004604
48MP0002063_abnormal_learning/memory/cond1.43111934
49MP0003283_abnormal_digestive_organ1.42673877
50MP0005253_abnormal_eye_physiology1.42132409
51MP0005394_taste/olfaction_phenotype1.38778056
52MP0005499_abnormal_olfactory_system1.38778056
53MP0004043_abnormal_pH_regulation1.35827375
54MP0003938_abnormal_ear_development1.35750873
55MP0001661_extended_life_span1.35168408
56MP0000631_abnormal_neuroendocrine_gland1.32096840
57MP0002734_abnormal_mechanical_nocicepti1.30301575
58MP0001905_abnormal_dopamine_level1.29825273
59MP0002249_abnormal_larynx_morphology1.28781891
60MP0002557_abnormal_social/conspecific_i1.28370573
61MP0002735_abnormal_chemical_nociception1.28107021
62MP0003718_maternal_effect1.25001347
63MP0002752_abnormal_somatic_nervous1.25001138
64MP0005075_abnormal_melanosome_morpholog1.24569812
65MP0002229_neurodegeneration1.23671486
66MP0001984_abnormal_olfaction1.23081764
67MP0002139_abnormal_hepatobiliary_system1.23081355
68MP0002736_abnormal_nociception_after1.23066100
69MP0001501_abnormal_sleep_pattern1.20787349
70MP0008789_abnormal_olfactory_epithelium1.20103103
71MP0003634_abnormal_glial_cell1.19853100
72MP0006072_abnormal_retinal_apoptosis1.19326722
73MP0003950_abnormal_plasma_membrane1.18324061
74MP0002909_abnormal_adrenal_gland1.17383424
75MP0001502_abnormal_circadian_rhythm1.16764395
76MP0005195_abnormal_posterior_eye1.15804455
77MP0002882_abnormal_neuron_morphology1.12249846
78MP0005451_abnormal_body_composition1.10575954
79MP0005410_abnormal_fertilization1.10131785
80MP0004924_abnormal_behavior1.09091543
81MP0005386_behavior/neurological_phenoty1.09091543
82MP0009250_abnormal_appendicular_skeleto1.07921475
83MP0003698_abnormal_male_reproductive1.07015641
84MP0005379_endocrine/exocrine_gland_phen1.06340034
85MP0003122_maternal_imprinting1.05853918
86MP0002090_abnormal_vision1.05498863
87MP0005360_urolithiasis1.05286890
88MP0004019_abnormal_vitamin_homeostasis1.04976639
89MP0002653_abnormal_ependyma_morphology1.04679665
90MP0003787_abnormal_imprinting1.03770451
91MP0000462_abnormal_digestive_system1.02685063
92MP0001970_abnormal_pain_threshold1.01955250
93MP0002152_abnormal_brain_morphology0.99414417
94MP0002184_abnormal_innervation0.99171078
95MP0004811_abnormal_neuron_physiology0.99153745
96MP0001929_abnormal_gametogenesis0.98877388
97MP0009780_abnormal_chondrocyte_physiolo0.96959083
98MP0008569_lethality_at_weaning0.96882077
99MP0006276_abnormal_autonomic_nervous0.95051424
100MP0003329_amyloid_beta_deposits0.94474361
101MP0008995_early_reproductive_senescence0.93692110
102MP0005377_hearing/vestibular/ear_phenot0.92190973
103MP0003878_abnormal_ear_physiology0.92190973
104MP0002066_abnormal_motor_capabilities/c0.91760789
105MP0000049_abnormal_middle_ear0.91171535
106MP0001324_abnormal_eye_pigmentation0.89646674
107MP0000955_abnormal_spinal_cord0.88630747
108MP0002733_abnormal_thermal_nociception0.88258732
109MP0002638_abnormal_pupillary_reflex0.87305279
110MP0003879_abnormal_hair_cell0.86711003
111MP0003633_abnormal_nervous_system0.86488155
112MP0001529_abnormal_vocalization0.85489488
113MP0003121_genomic_imprinting0.83979775
114MP0000383_abnormal_hair_follicle0.80886793
115MP0001177_atelectasis0.80683158
116MP0005391_vision/eye_phenotype0.80524695
117MP0010386_abnormal_urinary_bladder0.80030021
118MP0003631_nervous_system_phenotype0.78976727
119MP0002210_abnormal_sex_determination0.78552477
120MP0005647_abnormal_sex_gland0.78221678
121MP0002277_abnormal_respiratory_mucosa0.77836544
122MP0005670_abnormal_white_adipose0.77741123
123MP0005187_abnormal_penis_morphology0.77285588
124MP0003937_abnormal_limbs/digits/tail_de0.77132708
125MP0000427_abnormal_hair_cycle0.76672259
126MP0005595_abnormal_vascular_smooth0.75900900
127MP0003123_paternal_imprinting0.74988752
128MP0008875_abnormal_xenobiotic_pharmacok0.74259710
129MP0003632_abnormal_nervous_system0.72220906
130MP0000015_abnormal_ear_pigmentation0.71839192
131MP0004134_abnormal_chest_morphology0.71195946
132MP0000579_abnormal_nail_morphology0.70133673
133MP0002938_white_spotting0.69852548
134MP0003868_abnormal_feces_composition0.69542938
135MP0000647_abnormal_sebaceous_gland0.68482555

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.75479511
2Dynein arm defect of respiratory motile cilia (HP:0012255)3.72356333
3Absent/shortened dynein arms (HP:0200106)3.72356333
4Septo-optic dysplasia (HP:0100842)3.70564136
5Focal motor seizures (HP:0011153)3.60867759
6Hyperinsulinemic hypoglycemia (HP:0000825)3.37589821
7Decreased central vision (HP:0007663)3.37116888
8Large for gestational age (HP:0001520)3.22138095
9Parakeratosis (HP:0001036)3.15552998
10Abnormal ciliary motility (HP:0012262)3.14419888
11Myokymia (HP:0002411)3.13592948
12Hyperventilation (HP:0002883)3.13152868
13Metabolic alkalosis (HP:0200114)3.12087788
14Abnormal respiratory motile cilium physiology (HP:0012261)3.01965212
15Hypoglycemic seizures (HP:0002173)2.98781492
16Epileptiform EEG discharges (HP:0011182)2.90589268
17Hypomagnesemia (HP:0002917)2.84195524
18Absent septum pellucidum (HP:0001331)2.79760900
19EEG with generalized epileptiform discharges (HP:0011198)2.79643387
20Hypsarrhythmia (HP:0002521)2.79203110
21Intestinal atresia (HP:0011100)2.76983989
22Congenital stationary night blindness (HP:0007642)2.72477823
23Increased circulating renin level (HP:0000848)2.72315072
24Tubulointerstitial nephritis (HP:0001970)2.71139214
25Hypophosphatemic rickets (HP:0004912)2.70389941
26Hypoglycemic coma (HP:0001325)2.68008591
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64352873
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.64352873
29Febrile seizures (HP:0002373)2.63529274
30Neurofibrillary tangles (HP:0002185)2.62671456
31Abnormal respiratory motile cilium morphology (HP:0005938)2.59621500
32Abnormal respiratory epithelium morphology (HP:0012253)2.59621500
33White forelock (HP:0002211)2.59340072
34Pancreatic islet-cell hyperplasia (HP:0004510)2.59175012
35Atonic seizures (HP:0010819)2.55373511
36Retinal dysplasia (HP:0007973)2.55212955
37Hypoplasia of the fovea (HP:0007750)2.54914760
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.54914760
39Dyschromatopsia (HP:0007641)2.52589017
40Patchy hypopigmentation of hair (HP:0011365)2.50113419
41Papillary thyroid carcinoma (HP:0002895)2.45794572
42Prolonged partial thromboplastin time (HP:0003645)2.45489819
43Megalencephaly (HP:0001355)2.39297490
44Optic nerve hypoplasia (HP:0000609)2.38106601
45Neoplasm of the oral cavity (HP:0100649)2.37862799
46Chronic hepatic failure (HP:0100626)2.37006284
47Gastrointestinal atresia (HP:0002589)2.36733081
48Aplasia involving bones of the upper limbs (HP:0009823)2.36194599
49Aplasia of the phalanges of the hand (HP:0009802)2.36194599
50Aplasia involving bones of the extremities (HP:0009825)2.36194599
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35331928
52Attenuation of retinal blood vessels (HP:0007843)2.34459832
53Congenital sensorineural hearing impairment (HP:0008527)2.33961873
54Abnormality of the septum pellucidum (HP:0007375)2.32768627
55Generalized tonic-clonic seizures (HP:0002069)2.30310272
56Oligodactyly (HP:0012165)2.29933998
57Osteomalacia (HP:0002749)2.25745682
58Confusion (HP:0001289)2.25432026
59Hemiplegia (HP:0002301)2.24172660
60Anomalous pulmonary venous return (HP:0010772)2.22319925
61Gaze-evoked nystagmus (HP:0000640)2.22294499
62Oligodactyly (hands) (HP:0001180)2.22233205
63Hyperglycemia (HP:0003074)2.21130416
64Peripheral hypomyelination (HP:0007182)2.20795912
65Abnormality of the labia minora (HP:0012880)2.20253138
66Abnormality of the metopic suture (HP:0005556)2.18675085
67Renal hypoplasia (HP:0000089)2.17501707
68Abnormality of the fovea (HP:0000493)2.17251386
69Abnormality of magnesium homeostasis (HP:0004921)2.16796297
70Aplasia cutis congenita (HP:0001057)2.16519104
71Abolished electroretinogram (ERG) (HP:0000550)2.14651621
72Action tremor (HP:0002345)2.13955623
73Insulin-resistant diabetes mellitus (HP:0000831)2.13881697
74Hypokalemic alkalosis (HP:0001949)2.12670490
75Vitreoretinal degeneration (HP:0000655)2.12259273
76Nephronophthisis (HP:0000090)2.11743963
77Onion bulb formation (HP:0003383)2.11338613
78Gait imbalance (HP:0002141)2.10788202
79Abnormality of the renal medulla (HP:0100957)2.08865248
80Joint hemorrhage (HP:0005261)2.08207013
81Alacrima (HP:0000522)2.07696792
82Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07537864
83Thyroid-stimulating hormone excess (HP:0002925)2.06560162
84Epileptic encephalopathy (HP:0200134)2.06397153
85Abnormality of the axillary hair (HP:0100134)2.05582361
86Abnormality of secondary sexual hair (HP:0009888)2.05582361
87Absent speech (HP:0001344)2.05579994
88Synostosis involving the elbow (HP:0003938)2.05140182
89Humeroradial synostosis (HP:0003041)2.05140182
90Enlarged kidneys (HP:0000105)2.04185898
91Abnormal auditory evoked potentials (HP:0006958)2.03750526
92Prolonged neonatal jaundice (HP:0006579)2.02987068
93Heterochromia iridis (HP:0001100)2.01947131
94Abnormality of the pancreatic islet cells (HP:0006476)2.00549220
95Abnormality of endocrine pancreas physiology (HP:0012093)2.00549220
96Cupped ear (HP:0000378)2.00288874
97Progressive cerebellar ataxia (HP:0002073)1.99587810
98Partial agenesis of the corpus callosum (HP:0001338)1.99172528
99Abnormal rod and cone electroretinograms (HP:0008323)1.96371332
100Hemiparesis (HP:0001269)1.96272020
101Bifid scrotum (HP:0000048)1.95864139
102Medial flaring of the eyebrow (HP:0010747)1.95510867
103Conical tooth (HP:0000698)1.94679655
104Enlarged penis (HP:0000040)1.93740422
105Nasolacrimal duct obstruction (HP:0000579)1.93483772
106Abnormality of the pulmonary veins (HP:0011718)1.92979697
107Increased corneal curvature (HP:0100692)1.92495650
108Keratoconus (HP:0000563)1.92495650
109Abnormality of the astrocytes (HP:0100707)1.92355591
110Astrocytoma (HP:0009592)1.92355591
111Dialeptic seizures (HP:0011146)1.91576198
112Abnormality of midbrain morphology (HP:0002418)1.91281194
113Molar tooth sign on MRI (HP:0002419)1.91281194
114Split foot (HP:0001839)1.91266720
115True hermaphroditism (HP:0010459)1.91157800
116Hypopigmentation of the fundus (HP:0007894)1.90673490
117Dysdiadochokinesis (HP:0002075)1.90174880
118Abnormal eating behavior (HP:0100738)1.88483030
119Abnormal drinking behavior (HP:0030082)1.88098624
120Polydipsia (HP:0001959)1.88098624
121Abnormality of incisor morphology (HP:0011063)1.87681868
122Spastic gait (HP:0002064)1.87313260
123Clumsiness (HP:0002312)1.86684232
124Hypoplastic nipples (HP:0002557)1.86621636
125Aplasia/Hypoplasia of the macula (HP:0008059)1.86188065
126Rhinitis (HP:0012384)1.85291443
127Dysmetria (HP:0001310)1.83463469
128Ocular albinism (HP:0001107)1.83198246
129Postural instability (HP:0002172)1.83074837
130Renal cortical cysts (HP:0000803)1.82073410
131Broad-based gait (HP:0002136)1.81967551
132Slow saccadic eye movements (HP:0000514)1.81223983
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80889984
134Genital tract atresia (HP:0001827)1.80861484
135Mixed hearing impairment (HP:0000410)1.80522426
136Poor eye contact (HP:0000817)1.80141002
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.80023982
138Abnormality of renin-angiotensin system (HP:0000847)1.79964317
139Iris hypopigmentation (HP:0007730)1.79758120
140Congenital primary aphakia (HP:0007707)1.79422056
141Morphological abnormality of the inner ear (HP:0011390)1.78112299
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.78004038
143Abnormality of the corticospinal tract (HP:0002492)1.76961549
144Gonadotropin excess (HP:0000837)1.76595085
145Bell-shaped thorax (HP:0001591)1.76284629
146Decreased lacrimation (HP:0000633)1.76203446
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74867779
148Overfolded helix (HP:0000396)1.74778171
149Abnormality of the diencephalon (HP:0010662)1.74760762
150Polyuria (HP:0000103)1.74337057
151Vascular calcification (HP:0004934)1.74328325
152Glioma (HP:0009733)1.74078439
153Ketoacidosis (HP:0001993)1.73907808
154Blue irides (HP:0000635)1.73005178
155Hyperkalemia (HP:0002153)1.72945711
156Hypoplastic left heart (HP:0004383)1.72634811
157Hyperaldosteronism (HP:0000859)1.72612469
158Short tibia (HP:0005736)1.72532908
159Cerebellar dysplasia (HP:0007033)1.72038658
160Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71907956
161Absence seizures (HP:0002121)1.71656638
162Abnormality of the lacrimal duct (HP:0011481)1.70008540
163Tracheomalacia (HP:0002779)1.69728004
164Tubulointerstitial abnormality (HP:0001969)1.69194381
165Focal seizures (HP:0007359)1.69079481
166Bony spicule pigmentary retinopathy (HP:0007737)1.68879272
167Fibular hypoplasia (HP:0003038)1.68833547
168Pheochromocytoma (HP:0002666)1.68482029
169Status epilepticus (HP:0002133)1.68385383
170Ankle clonus (HP:0011448)1.68191024
171Impaired vibration sensation in the lower limbs (HP:0002166)1.65253024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.73073020
2TNIK4.60799341
3STK393.20509213
4OXSR12.62605378
5BLK2.48731266
6MUSK2.33485936
7INSRR2.28681011
8EPHA42.26102775
9MAP3K92.24851482
10FRK2.22617102
11MKNK22.21675896
12NTRK32.20275267
13PRKD32.10747612
14PKN11.93240925
15WNK41.90223337
16PLK21.87134557
17TYRO31.71744628
18GRK11.71625482
19NEK61.61749512
20EPHB11.61478041
21MAP3K131.59278702
22PRPF4B1.51928641
23ADRBK21.47061573
24MAP2K71.43974372
25PBK1.43965520
26NTRK21.37782874
27PNCK1.36459139
28IRAK21.34562929
29FES1.32257788
30STK161.32191887
31CAMK1G1.29904699
32FGR1.23132168
33IRAK11.19413123
34MAPK131.17997611
35STK38L1.10499725
36WNK11.09196496
37MAPK151.09194158
38SGK2231.06707613
39SGK4941.06707613
40MAP4K21.06150190
41BMPR21.05794549
42MKNK11.04061443
43CDK31.04034171
44CAMK2B1.03196633
45MINK11.02798424
46WNK31.02098671
47RIPK40.99540276
48MAP3K140.98572067
49CAMK2A0.97709291
50PLK40.94898437
51CLK10.92497597
52YES10.89101717
53BCR0.88458177
54GRK70.87427519
55PRKCE0.85848546
56WEE10.85152524
57MARK10.85084416
58CAMK2D0.84290694
59PRKAA20.83529189
60ERBB40.82254768
61MAP2K40.81229942
62NUAK10.80357507
63MARK20.77593185
64MAPKAPK50.77031408
65PTK2B0.75852493
66BMPR1B0.75672227
67SGK30.75462328
68NTRK10.74785911
69PRKCQ0.73571738
70PINK10.73277494
71PRKD20.71979820
72KSR10.71564725
73NLK0.71367043
74ROCK10.70366390
75PHKG20.70256936
76PHKG10.70256936
77EIF2AK20.70230961
78SIK20.67910811
79ERBB20.67095645
80ROCK20.65385208
81CAMK2G0.64765341
82CAMK10.64304410
83PRKG10.63758995
84UHMK10.63680976
85SGK10.62927167
86TAOK30.62285052
87STK30.61239955
88IRAK40.60262422
89BRD40.59963059
90AKT30.58641675
91CAMK1D0.57769247
92PAK30.56407082
93CSNK1A1L0.56335934
94PRKCZ0.55997050
95TAF10.55845804
96PIK3CA0.55561484
97DYRK1A0.54921226
98TRIM280.54629369
99CDK50.54592405
100ARAF0.54240858
101MAP3K40.53843318
102STK380.53144771
103MAPK100.52626551
104CSNK1G10.51536517
105PRKCH0.50810126
106SGK20.50745765
107PRKCG0.50389113
108PRKACA0.48474127
109DMPK0.48137705
110CAMKK10.47822312
111PAK60.47809326
112CAMK40.47323358
113FYN0.45918863
114KSR20.45769664
115LATS10.45471975
116MET0.44981947
117GSK3A0.44798880
118FGFR20.43823698
119TXK0.42997175
120RPS6KA30.42817812
121ADRBK10.42525220
122CDK150.41969481
123DAPK20.41633059
124CDK180.41509441
125CSNK1G20.40590879
126PRKDC0.40039218
127MAPK120.39474103
128PIK3CG0.39390716
129BRSK10.39233419
130MAPK70.39086416
131MAP3K70.37810709
132CSNK1A10.37579667
133CDK11A0.37296112
134TNK20.37111828
135MST1R0.35536705
136DYRK20.35425215
137CSNK1G30.35374169
138CDK140.34821669
139CSNK1D0.34739328
140CDK190.34606130
141STK110.33193766

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.02172298
2Nicotine addiction_Homo sapiens_hsa050332.57692583
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51028897
4Steroid biosynthesis_Homo sapiens_hsa001002.40947399
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20573227
6Fatty acid elongation_Homo sapiens_hsa000622.20503337
7Ether lipid metabolism_Homo sapiens_hsa005651.98670605
8Nitrogen metabolism_Homo sapiens_hsa009101.96843867
9Glutamatergic synapse_Homo sapiens_hsa047241.93584192
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87691482
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75168321
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75126515
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.74469353
14GABAergic synapse_Homo sapiens_hsa047271.71748274
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66961867
16Morphine addiction_Homo sapiens_hsa050321.66652813
17Vitamin digestion and absorption_Homo sapiens_hsa049771.60729418
18Long-term potentiation_Homo sapiens_hsa047201.57298302
19Histidine metabolism_Homo sapiens_hsa003401.54480991
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51922883
21Sphingolipid metabolism_Homo sapiens_hsa006001.50379121
22Serotonergic synapse_Homo sapiens_hsa047261.47911110
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45955926
24Butanoate metabolism_Homo sapiens_hsa006501.45817929
25Taste transduction_Homo sapiens_hsa047421.37900049
26Circadian rhythm_Homo sapiens_hsa047101.35443064
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30437974
28Axon guidance_Homo sapiens_hsa043601.30303826
29Retinol metabolism_Homo sapiens_hsa008301.29140183
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28840700
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26412935
32Type II diabetes mellitus_Homo sapiens_hsa049301.26359273
33Salivary secretion_Homo sapiens_hsa049701.26159727
34Linoleic acid metabolism_Homo sapiens_hsa005911.25706864
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.21944910
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20092387
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20075830
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18941973
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18320210
40Oocyte meiosis_Homo sapiens_hsa041141.14653105
41Circadian entrainment_Homo sapiens_hsa047131.10788863
42Thyroid hormone synthesis_Homo sapiens_hsa049181.02995316
43Regulation of autophagy_Homo sapiens_hsa041401.02243177
44Melanogenesis_Homo sapiens_hsa049161.01161706
45Complement and coagulation cascades_Homo sapiens_hsa046101.00950267
46Sulfur metabolism_Homo sapiens_hsa009200.98818476
47Ovarian steroidogenesis_Homo sapiens_hsa049130.98385288
48Calcium signaling pathway_Homo sapiens_hsa040200.97393752
49Collecting duct acid secretion_Homo sapiens_hsa049660.96956065
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95761379
51Peroxisome_Homo sapiens_hsa041460.95355776
52Fatty acid biosynthesis_Homo sapiens_hsa000610.94331459
53beta-Alanine metabolism_Homo sapiens_hsa004100.93193964
54Cocaine addiction_Homo sapiens_hsa050300.92988352
55Inositol phosphate metabolism_Homo sapiens_hsa005620.92076930
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90786436
57Gap junction_Homo sapiens_hsa045400.90710205
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90439499
59Estrogen signaling pathway_Homo sapiens_hsa049150.90059397
60Gastric acid secretion_Homo sapiens_hsa049710.89738433
61Long-term depression_Homo sapiens_hsa047300.88260593
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86500192
63Arginine and proline metabolism_Homo sapiens_hsa003300.86151499
64Arachidonic acid metabolism_Homo sapiens_hsa005900.85536333
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85108756
66ABC transporters_Homo sapiens_hsa020100.84929495
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84553576
68Bile secretion_Homo sapiens_hsa049760.81128738
69Insulin secretion_Homo sapiens_hsa049110.80865941
70Mineral absorption_Homo sapiens_hsa049780.80695811
71Tryptophan metabolism_Homo sapiens_hsa003800.79720618
72Cholinergic synapse_Homo sapiens_hsa047250.78502541
73cAMP signaling pathway_Homo sapiens_hsa040240.78418967
74Chemical carcinogenesis_Homo sapiens_hsa052040.75908075
75Basal transcription factors_Homo sapiens_hsa030220.75641149
76Fanconi anemia pathway_Homo sapiens_hsa034600.74565299
77Olfactory transduction_Homo sapiens_hsa047400.74437194
78Hedgehog signaling pathway_Homo sapiens_hsa043400.74034845
79Pancreatic secretion_Homo sapiens_hsa049720.73823731
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73578577
81Staphylococcus aureus infection_Homo sapiens_hsa051500.72291911
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71837606
83Renin secretion_Homo sapiens_hsa049240.71622969
84African trypanosomiasis_Homo sapiens_hsa051430.71312145
85Lysine degradation_Homo sapiens_hsa003100.70903624
86Rheumatoid arthritis_Homo sapiens_hsa053230.69275818
87Protein export_Homo sapiens_hsa030600.68142012
88Autoimmune thyroid disease_Homo sapiens_hsa053200.66931703
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66279296
90Amphetamine addiction_Homo sapiens_hsa050310.65577507
91Fatty acid metabolism_Homo sapiens_hsa012120.64820947
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.63972536
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.63324968
94PPAR signaling pathway_Homo sapiens_hsa033200.61985651
95Arginine biosynthesis_Homo sapiens_hsa002200.61785723
96Synaptic vesicle cycle_Homo sapiens_hsa047210.61106958
97Hippo signaling pathway_Homo sapiens_hsa043900.60656961
98Vitamin B6 metabolism_Homo sapiens_hsa007500.60623407
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59822317
100Ras signaling pathway_Homo sapiens_hsa040140.59574334
101Dopaminergic synapse_Homo sapiens_hsa047280.57709088
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56711660
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56478404
104Wnt signaling pathway_Homo sapiens_hsa043100.55806324
105Propanoate metabolism_Homo sapiens_hsa006400.55670443
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54182942
107Glioma_Homo sapiens_hsa052140.54087712
108Dorso-ventral axis formation_Homo sapiens_hsa043200.53927783
109Tyrosine metabolism_Homo sapiens_hsa003500.53729034
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53437023
111Graft-versus-host disease_Homo sapiens_hsa053320.52684646
112ErbB signaling pathway_Homo sapiens_hsa040120.51540277
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51141627
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50629752
115Oxytocin signaling pathway_Homo sapiens_hsa049210.49217499
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49124387
117Cardiac muscle contraction_Homo sapiens_hsa042600.47510659
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.46797110
119Vibrio cholerae infection_Homo sapiens_hsa051100.46623674
120GnRH signaling pathway_Homo sapiens_hsa049120.46531569
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.46413061
122Asthma_Homo sapiens_hsa053100.46078311
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44848462
124Glycerolipid metabolism_Homo sapiens_hsa005610.44736848
125Glucagon signaling pathway_Homo sapiens_hsa049220.43099883
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42281115
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41476753
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39869033
129Non-homologous end-joining_Homo sapiens_hsa034500.39538078
130Choline metabolism in cancer_Homo sapiens_hsa052310.38847001
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38301071
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37231205
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37095169
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36965273
135Homologous recombination_Homo sapiens_hsa034400.36524430
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35952892

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