IGSF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.01503585
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.91475788
3synaptic vesicle maturation (GO:0016188)5.83740081
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82093411
5protein localization to synapse (GO:0035418)5.74968068
6locomotory exploration behavior (GO:0035641)5.56837899
7vocalization behavior (GO:0071625)5.29993970
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26511029
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15845910
10layer formation in cerebral cortex (GO:0021819)5.10862121
11neuron cell-cell adhesion (GO:0007158)5.03675342
12regulation of synaptic vesicle exocytosis (GO:2000300)5.01003207
13response to pheromone (GO:0019236)4.98243628
14glutamate secretion (GO:0014047)4.98036087
15cellular potassium ion homeostasis (GO:0030007)4.87673394
16exploration behavior (GO:0035640)4.86955267
17positive regulation of synapse maturation (GO:0090129)4.81623111
18neuronal ion channel clustering (GO:0045161)4.73610379
19regulation of glutamate receptor signaling pathway (GO:1900449)4.45906988
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.34857413
21regulation of synaptic vesicle transport (GO:1902803)4.33918845
22presynaptic membrane organization (GO:0097090)4.32401046
23neurotransmitter secretion (GO:0007269)4.27902410
24neurotransmitter-gated ion channel clustering (GO:0072578)4.26093833
25central nervous system myelination (GO:0022010)4.21158430
26axon ensheathment in central nervous system (GO:0032291)4.21158430
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.20678910
28sodium ion export (GO:0071436)4.20016260
29glutamate receptor signaling pathway (GO:0007215)4.16518122
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.13863655
31regulation of synapse structural plasticity (GO:0051823)4.12572598
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.10352205
33synaptic vesicle endocytosis (GO:0048488)4.07804063
34synaptic transmission, glutamatergic (GO:0035249)4.01642556
35gamma-aminobutyric acid signaling pathway (GO:0007214)4.01133534
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99770769
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86834597
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79976312
39regulation of neuronal synaptic plasticity (GO:0048168)3.79609764
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.79154137
41neuron-neuron synaptic transmission (GO:0007270)3.77867570
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.73716826
43presynaptic membrane assembly (GO:0097105)3.72410952
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69378786
45dendritic spine morphogenesis (GO:0060997)3.68368411
46innervation (GO:0060384)3.66487482
47regulation of synapse maturation (GO:0090128)3.66234678
48establishment of mitochondrion localization (GO:0051654)3.64711675
49cell communication by electrical coupling (GO:0010644)3.62587239
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62052099
51long-term synaptic potentiation (GO:0060291)3.61650338
52neuron recognition (GO:0008038)3.60732525
53L-amino acid import (GO:0043092)3.60564999
54dendrite morphogenesis (GO:0048813)3.59628959
55postsynaptic membrane organization (GO:0001941)3.59555426
56regulation of vesicle fusion (GO:0031338)3.59371205
57long-term memory (GO:0007616)3.56973121
58response to auditory stimulus (GO:0010996)3.56867413
59potassium ion homeostasis (GO:0055075)3.53709143
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.53622212
61positive regulation of membrane potential (GO:0045838)3.52850803
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.52497068
63neuronal action potential propagation (GO:0019227)3.51079435
64regulation of neurotransmitter secretion (GO:0046928)3.50109637
65potassium ion import (GO:0010107)3.50079030
66neurotransmitter transport (GO:0006836)3.49643539
67positive regulation of neurotransmitter transport (GO:0051590)3.47337293
68auditory behavior (GO:0031223)3.43957239
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43477502
70adult walking behavior (GO:0007628)3.40404519
71mechanosensory behavior (GO:0007638)3.39079177
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38870402
73regulation of postsynaptic membrane potential (GO:0060078)3.37427181
74mating behavior (GO:0007617)3.35607608
75proline transport (GO:0015824)3.34766723
76prepulse inhibition (GO:0060134)3.34482697
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31488362
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30525279
79cerebellar Purkinje cell differentiation (GO:0021702)3.29960840
80synapse assembly (GO:0007416)3.29614650
81regulation of dendritic spine morphogenesis (GO:0061001)3.28085915
82cell migration in hindbrain (GO:0021535)3.27917917
83regulation of dendritic spine development (GO:0060998)3.27749076
84gamma-aminobutyric acid transport (GO:0015812)3.27407477
85cell differentiation in hindbrain (GO:0021533)3.27072350
86axonal fasciculation (GO:0007413)3.26600259
87transmission of nerve impulse (GO:0019226)3.26472562
88membrane hyperpolarization (GO:0060081)3.24784188
89neuromuscular synaptic transmission (GO:0007274)3.24081901
90cerebellar granule cell differentiation (GO:0021707)3.24074940
91regulation of neurotransmitter transport (GO:0051588)3.23291094
92amino acid import (GO:0043090)3.21484724
93positive regulation of neurotransmitter secretion (GO:0001956)3.19709846
94neuromuscular process controlling posture (GO:0050884)3.19579886
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.17971910
96mitochondrion transport along microtubule (GO:0047497)3.17971910
97negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17538391
98regulation of synaptic plasticity (GO:0048167)3.17179988
99activation of protein kinase A activity (GO:0034199)3.15935725
100regulation of neurotransmitter levels (GO:0001505)3.15338878
101establishment of synaptic vesicle localization (GO:0097480)3.14887135
102synaptic vesicle transport (GO:0048489)3.14887135
103neuromuscular process controlling balance (GO:0050885)3.12168753
104positive regulation of potassium ion transmembrane transport (GO:1901381)3.11841626
105positive regulation of dendritic spine development (GO:0060999)3.11365746
106regulation of voltage-gated calcium channel activity (GO:1901385)3.10774115
107cellular sodium ion homeostasis (GO:0006883)3.10048390
108pyrimidine nucleobase catabolic process (GO:0006208)3.09301105
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08725657
110negative regulation of microtubule polymerization (GO:0031115)3.08034526
111striatum development (GO:0021756)3.07894908
112chemosensory behavior (GO:0007635)3.04567316
113glycine transport (GO:0015816)3.03937631
114regulation of synaptic transmission (GO:0050804)3.02021901
115cerebellar Purkinje cell layer development (GO:0021680)3.01929978
116dendritic spine organization (GO:0097061)3.00715692
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00453471
118membrane depolarization during action potential (GO:0086010)3.00196711
119learning (GO:0007612)2.99495374
120synapse organization (GO:0050808)2.98563637
121membrane depolarization (GO:0051899)2.97585379
122positive regulation of synaptic transmission (GO:0050806)2.96183297
123retinal rod cell development (GO:0046548)2.95457822
124axon cargo transport (GO:0008088)2.95407071
125behavioral fear response (GO:0001662)2.92036227
126behavioral defense response (GO:0002209)2.92036227
127synaptic transmission (GO:0007268)2.92008645
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.91580590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.53575150
2GBX2_23144817_ChIP-Seq_PC3_Human3.27513982
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21550591
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19353075
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06973285
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.98625745
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83243494
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76152114
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76152114
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75369203
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.75298052
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63451432
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59542385
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.58000758
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57147107
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.53500047
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50849165
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49408742
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.45464888
20* DROSHA_22980978_ChIP-Seq_HELA_Human2.44307372
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.42388889
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.38817352
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38392074
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.36948515
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26410162
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21960470
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20219714
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11302963
29AR_21572438_ChIP-Seq_LNCaP_Human2.09403050
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84485496
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72804345
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69569624
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62191322
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.61892794
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55904446
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53928179
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51574259
38* RING1B_27294783_Chip-Seq_ESCs_Mouse1.49905368
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49364162
40IGF1R_20145208_ChIP-Seq_DFB_Human1.48400840
41ZNF274_21170338_ChIP-Seq_K562_Hela1.47700254
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46480372
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.46422966
44TAF15_26573619_Chip-Seq_HEK293_Human1.45663019
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.44936105
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39745468
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34113339
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29322056
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.29190396
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29069750
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27063650
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25507083
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25217431
54RNF2_27304074_Chip-Seq_NSC_Mouse1.25086842
55P300_19829295_ChIP-Seq_ESCs_Human1.24380313
56* SMAD3_21741376_ChIP-Seq_EPCs_Human1.23858455
57* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23221503
58AR_19668381_ChIP-Seq_PC3_Human1.23143072
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22613618
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22463757
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19570245
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18842042
63* AR_25329375_ChIP-Seq_VCAP_Human1.18350187
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12721602
65KDM2B_26808549_Chip-Seq_K562_Human1.10678050
66STAT3_23295773_ChIP-Seq_U87_Human1.10288523
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09311712
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08042234
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07950519
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07767272
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07177969
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05867214
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05836358
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05640188
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.05209954
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04395008
77* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04253106
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03657756
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01472303
80* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00431328
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99818254
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97749824
83* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97717763
84* TCF4_23295773_ChIP-Seq_U87_Human0.97709501
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.95930082
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.95921068
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95379588
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95379588
89CTCF_27219007_Chip-Seq_Bcells_Human0.94576679
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94536825
91OCT4_19829295_ChIP-Seq_ESCs_Human0.92984483
92* TP53_20018659_ChIP-ChIP_R1E_Mouse0.90102873
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89036772
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88179616
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86407714
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86005392
97FUS_26573619_Chip-Seq_HEK293_Human0.85567017
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84736385
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.84651430
100RUNX2_22187159_ChIP-Seq_PCA_Human0.84561022
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.84496919
102* SMAD3_21741376_ChIP-Seq_HESCs_Human0.84003908
103VDR_22108803_ChIP-Seq_LS180_Human0.83860642
104* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83414923
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.83088119
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82229983
107* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82131947
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81948742
109* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81844063
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81273267
111* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80708874
112* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80211169
113DPY_21335234_ChIP-Seq_ESCs_Mouse0.77353999
114SOX9_26525672_Chip-Seq_HEART_Mouse0.76612600
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.73111354
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72931259
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72735848
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71587821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49822701
2MP0003880_abnormal_central_pattern4.30115520
3MP0003635_abnormal_synaptic_transmissio3.82822527
4MP0004270_analgesia3.49535595
5MP0002063_abnormal_learning/memory/cond3.12279080
6MP0005423_abnormal_somatic_nervous3.04568707
7MP0009745_abnormal_behavioral_response2.98455285
8MP0009046_muscle_twitch2.95831221
9MP0002064_seizures2.83666121
10MP0002734_abnormal_mechanical_nocicepti2.76605594
11MP0001968_abnormal_touch/_nociception2.72946952
12MP0001486_abnormal_startle_reflex2.59529016
13MP0002572_abnormal_emotion/affect_behav2.58271905
14MP0003123_paternal_imprinting2.42564845
15MP0002272_abnormal_nervous_system2.38716062
16MP0005551_abnormal_eye_electrophysiolog2.36423307
17MP0001984_abnormal_olfaction2.35502920
18MP0002184_abnormal_innervation2.23253247
19MP0002736_abnormal_nociception_after2.16640520
20MP0002735_abnormal_chemical_nociception2.09666423
21MP0000778_abnormal_nervous_system2.06955863
22MP0002067_abnormal_sensory_capabilities2.06942576
23MP0001502_abnormal_circadian_rhythm2.03956267
24MP0001440_abnormal_grooming_behavior2.03579486
25MP0002733_abnormal_thermal_nociception1.95303651
26MP0008569_lethality_at_weaning1.92537601
27MP0006276_abnormal_autonomic_nervous1.91931810
28MP0005645_abnormal_hypothalamus_physiol1.89304108
29MP0001970_abnormal_pain_threshold1.88225773
30MP0002557_abnormal_social/conspecific_i1.84759464
31MP0002822_catalepsy1.82927769
32MP0002909_abnormal_adrenal_gland1.80006749
33MP0006072_abnormal_retinal_apoptosis1.79985456
34MP0003329_amyloid_beta_deposits1.79890115
35MP0001501_abnormal_sleep_pattern1.76804642
36MP0004858_abnormal_nervous_system1.73242727
37MP0000955_abnormal_spinal_cord1.73073473
38MP0004811_abnormal_neuron_physiology1.72484745
39MP0002882_abnormal_neuron_morphology1.64368816
40MP0002090_abnormal_vision1.63819344
41MP0009780_abnormal_chondrocyte_physiolo1.63733809
42MP0003879_abnormal_hair_cell1.61523232
43MP0005386_behavior/neurological_phenoty1.59839081
44MP0004924_abnormal_behavior1.59839081
45MP0008877_abnormal_DNA_methylation1.59698332
46MP0002638_abnormal_pupillary_reflex1.49188378
47MP0004885_abnormal_endolymph1.45950532
48MP0004142_abnormal_muscle_tone1.42968595
49MP0003121_genomic_imprinting1.42951088
50MP0010386_abnormal_urinary_bladder1.41287553
51MP0001529_abnormal_vocalization1.41146822
52MP0002066_abnormal_motor_capabilities/c1.40113158
53MP0006292_abnormal_olfactory_placode1.39369939
54MP0005499_abnormal_olfactory_system1.39092653
55MP0005394_taste/olfaction_phenotype1.39092653
56MP0005646_abnormal_pituitary_gland1.35013780
57MP0001485_abnormal_pinna_reflex1.31012175
58MP0005253_abnormal_eye_physiology1.28943329
59MP0000631_abnormal_neuroendocrine_gland1.26788601
60MP0002152_abnormal_brain_morphology1.26504322
61MP0003690_abnormal_glial_cell1.24973930
62MP0004233_abnormal_muscle_weight1.23766494
63MP0002229_neurodegeneration1.21918912
64MP0002752_abnormal_somatic_nervous1.18945797
65MP0004742_abnormal_vestibular_system1.16080742
66MP0001986_abnormal_taste_sensitivity1.15599210
67MP0003633_abnormal_nervous_system1.14923981
68MP0003122_maternal_imprinting1.13039020
69MP0002653_abnormal_ependyma_morphology1.08704167
70MP0004145_abnormal_muscle_electrophysio1.08532459
71MP0003631_nervous_system_phenotype1.03505407
72MP0003634_abnormal_glial_cell1.03453182
73MP0003787_abnormal_imprinting1.00587019
74MP0001188_hyperpigmentation1.00167794
75MP0002069_abnormal_eating/drinking_beha0.99980703
76MP0005195_abnormal_posterior_eye0.98697652
77MP0001905_abnormal_dopamine_level0.97142638
78MP0000751_myopathy0.94878739
79MP0008961_abnormal_basal_metabolism0.94507540
80MP0008789_abnormal_olfactory_epithelium0.94187482
81MP0003183_abnormal_peptide_metabolism0.92939554
82MP0000013_abnormal_adipose_tissue0.91825972
83MP0003632_abnormal_nervous_system0.86931373
84MP0001963_abnormal_hearing_physiology0.84262300
85MP0004215_abnormal_myocardial_fiber0.81146493
86MP0003861_abnormal_nervous_system0.80543479
87MP0008872_abnormal_physiological_respon0.78524903
88MP0003137_abnormal_impulse_conducting0.78188822
89MP0004133_heterotaxia0.75031895
90MP0002234_abnormal_pharynx_morphology0.74560937
91MP0005535_abnormal_body_temperature0.73487151
92MP0003938_abnormal_ear_development0.73449934
93MP0004085_abnormal_heartbeat0.72995933
94MP0005187_abnormal_penis_morphology0.72566072
95MP0004147_increased_porphyrin_level0.71110674
96MP0003172_abnormal_lysosome_physiology0.71049374
97MP0003283_abnormal_digestive_organ0.70796280
98MP0002751_abnormal_autonomic_nervous0.70595480
99MP0000604_amyloidosis0.68119036
100MP0004130_abnormal_muscle_cell0.64939153
101MP0001177_atelectasis0.64606880
102MP0005167_abnormal_blood-brain_barrier0.64077179
103MP0001299_abnormal_eye_distance/0.61003604
104MP0000026_abnormal_inner_ear0.60713448
105MP0008874_decreased_physiological_sensi0.59386320
106MP0000534_abnormal_ureter_morphology0.57876266
107MP0001943_abnormal_respiration0.57342885
108MP0010769_abnormal_survival0.56320745
109MP0000920_abnormal_myelination0.56273702
110MP0010770_preweaning_lethality0.55353101
111MP0002082_postnatal_lethality0.55353101
112MP0000569_abnormal_digit_pigmentation0.52803583
113MP0010768_mortality/aging0.52766773
114MP0001348_abnormal_lacrimal_gland0.50634554

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.20847802
2Focal motor seizures (HP:0011153)5.31093160
3Epileptic encephalopathy (HP:0200134)5.06435590
4Visual hallucinations (HP:0002367)5.04623910
5Focal seizures (HP:0007359)4.61743248
6Progressive cerebellar ataxia (HP:0002073)4.58507720
7Febrile seizures (HP:0002373)4.04366257
8Congenital stationary night blindness (HP:0007642)3.91120051
9Action tremor (HP:0002345)3.81835339
10Supranuclear gaze palsy (HP:0000605)3.77119841
11Absence seizures (HP:0002121)3.75828715
12Mutism (HP:0002300)3.57718002
13Atonic seizures (HP:0010819)3.42863996
14Generalized tonic-clonic seizures (HP:0002069)3.40936717
15Central scotoma (HP:0000603)3.39056730
16Depression (HP:0000716)3.36634969
17Ankle clonus (HP:0011448)3.36241406
18Dysdiadochokinesis (HP:0002075)3.33948381
19Hemiparesis (HP:0001269)3.30590959
20Cerebral hypomyelination (HP:0006808)3.29763370
21Dialeptic seizures (HP:0011146)3.28907188
22Broad-based gait (HP:0002136)3.06410117
23Anxiety (HP:0000739)3.00459040
24Megalencephaly (HP:0001355)2.96459179
25Sleep apnea (HP:0010535)2.95235100
26Abnormality of macular pigmentation (HP:0008002)2.94577623
27EEG with generalized epileptiform discharges (HP:0011198)2.92576316
28Epileptiform EEG discharges (HP:0011182)2.91910110
29Gaze-evoked nystagmus (HP:0000640)2.88943193
30Truncal ataxia (HP:0002078)2.87052034
31Neurofibrillary tangles (HP:0002185)2.81919422
32Excessive salivation (HP:0003781)2.81501220
33Drooling (HP:0002307)2.81501220
34Annular pancreas (HP:0001734)2.81443252
35Obstructive sleep apnea (HP:0002870)2.78601248
36Poor eye contact (HP:0000817)2.74955405
37Abnormal eating behavior (HP:0100738)2.74252480
38Polyphagia (HP:0002591)2.69905562
39Scotoma (HP:0000575)2.68764764
40Limb dystonia (HP:0002451)2.67695596
41Hyperventilation (HP:0002883)2.67232892
42Cerebral inclusion bodies (HP:0100314)2.66427975
43Abnormality of the lower motor neuron (HP:0002366)2.65882032
44Postural instability (HP:0002172)2.64951390
45Dysmetria (HP:0001310)2.64653528
46Urinary bladder sphincter dysfunction (HP:0002839)2.64086127
47Impaired vibration sensation in the lower limbs (HP:0002166)2.63677280
48Hypsarrhythmia (HP:0002521)2.58625229
49Peripheral hypomyelination (HP:0007182)2.58619136
50Amblyopia (HP:0000646)2.48836081
51Torticollis (HP:0000473)2.46516634
52Genetic anticipation (HP:0003743)2.45337404
53Impaired social interactions (HP:0000735)2.44619645
54Abnormal social behavior (HP:0012433)2.44619645
55Hemiplegia (HP:0002301)2.43987490
56Spastic gait (HP:0002064)2.39883257
57Bradykinesia (HP:0002067)2.33932175
58Absent speech (HP:0001344)2.33817768
59Impaired smooth pursuit (HP:0007772)2.33312185
60Urinary urgency (HP:0000012)2.29264466
61Abnormality of binocular vision (HP:0011514)2.29145809
62Diplopia (HP:0000651)2.29145809
63Tetraplegia (HP:0002445)2.28677822
64CNS hypomyelination (HP:0003429)2.27217626
65Septo-optic dysplasia (HP:0100842)2.26857240
66Scanning speech (HP:0002168)2.26186460
67Hepatoblastoma (HP:0002884)2.23819848
68Focal dystonia (HP:0004373)2.22414084
69Gait imbalance (HP:0002141)2.21710652
70Pheochromocytoma (HP:0002666)2.20206940
71Abnormality of the labia minora (HP:0012880)2.16359261
72Intention tremor (HP:0002080)2.13486725
73Impaired vibratory sensation (HP:0002495)2.13455126
74Ventricular fibrillation (HP:0001663)2.12868302
75Abnormality of ocular smooth pursuit (HP:0000617)2.11592036
76Abnormality of the corticospinal tract (HP:0002492)2.06635369
77Lower limb muscle weakness (HP:0007340)2.05551854
78Stereotypic behavior (HP:0000733)2.05334073
79Agitation (HP:0000713)2.05193745
80Insomnia (HP:0100785)2.04524192
81Apathy (HP:0000741)2.04117965
82Amyotrophic lateral sclerosis (HP:0007354)2.03807936
83Papilledema (HP:0001085)2.03000965
84Delusions (HP:0000746)2.02909780
85Abnormal rod and cone electroretinograms (HP:0008323)2.02467957
86Spastic tetraplegia (HP:0002510)2.01171933
87Craniofacial dystonia (HP:0012179)2.01139211
88Clonus (HP:0002169)2.00467068
89Fetal akinesia sequence (HP:0001989)1.98952943
90Neuronal loss in central nervous system (HP:0002529)1.98781171
91Progressive inability to walk (HP:0002505)1.98737836
92Specific learning disability (HP:0001328)1.94771755
93Status epilepticus (HP:0002133)1.93716839
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.93295082
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93295082
96Generalized myoclonic seizures (HP:0002123)1.92408381
97Morphological abnormality of the pyramidal tract (HP:0002062)1.88799787
98Poor suck (HP:0002033)1.86608160
99Hypoventilation (HP:0002791)1.86096518
100Pointed chin (HP:0000307)1.85799696
101Incomplete penetrance (HP:0003829)1.85279542
102Gait ataxia (HP:0002066)1.84586513
103Diminished motivation (HP:0000745)1.83397636
104Retinal dysplasia (HP:0007973)1.82775757
105Akinesia (HP:0002304)1.82177107
106Neuroendocrine neoplasm (HP:0100634)1.82174538
107Inability to walk (HP:0002540)1.81004271
108Failure to thrive in infancy (HP:0001531)1.80812765
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80569311
110Choreoathetosis (HP:0001266)1.80421807
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79995405
112Hypoplasia of the brainstem (HP:0002365)1.79995405
113Dysmetric saccades (HP:0000641)1.79425211
114Prolonged QT interval (HP:0001657)1.77612068
115Inappropriate behavior (HP:0000719)1.77416334
116Decreased central vision (HP:0007663)1.77287651
117Severe visual impairment (HP:0001141)1.75267140
118Lissencephaly (HP:0001339)1.74742810
119Spastic tetraparesis (HP:0001285)1.74740169
120Hypoplasia of the corpus callosum (HP:0002079)1.73520328
121Abnormal EKG (HP:0003115)1.72903482
122Abnormality of salivation (HP:0100755)1.72846053
123Thickened helices (HP:0000391)1.65863289
124Rigidity (HP:0002063)1.63095279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.36518297
2MAP3K93.56741723
3EPHA43.45992581
4NTRK33.23507053
5MINK13.03544314
6MAP3K42.88124957
7PAK62.76849811
8NTRK22.52671724
9MAP2K72.30501180
10PHKG22.30438033
11PHKG12.30438033
12DAPK22.20162058
13CASK2.17824033
14PRKD31.82433290
15KSR11.71215990
16KSR21.66892329
17MAPK131.61586820
18PRPF4B1.59729759
19NTRK11.59509606
20WNK31.59033395
21MAP2K41.58968084
22MAP3K121.56279850
23CAMKK11.54765396
24CDK51.48494614
25RIPK41.42719788
26TNIK1.41149516
27UHMK11.37422742
28STK381.32788060
29DAPK11.32506036
30PNCK1.28658589
31GRK51.26418728
32PLK21.25237320
33DYRK1A1.23774314
34TYRO31.22330106
35SIK21.19993255
36PRKCG1.18978002
37CDK191.11679703
38NEK11.05681826
39LMTK21.05395693
40CDK181.05298246
41RIPK11.04166833
42CAMKK21.04012924
43CDK141.03784283
44CDK151.02985691
45CAMK1D1.00046689
46FES0.96204853
47LATS20.94500215
48NME10.94316076
49PAK30.92787230
50CDK11A0.91295052
51SGK4940.91037444
52SGK2230.91037444
53PINK10.88214383
54CAMK2A0.85184158
55TAOK10.81637220
56STK110.78969109
57DYRK20.78724403
58ERBB30.77272838
59CAMK10.72546874
60CSNK1G20.72446957
61ARAF0.69176972
62FGFR20.68701355
63MAP3K20.68701015
64MARK20.67838345
65BRAF0.67773333
66RET0.67566047
67CAMK40.65996413
68PRKCZ0.65631803
69BMPR20.64964363
70CSNK1G30.63920572
71CSNK1A1L0.61375524
72CAMK2G0.61290461
73MAP3K130.57664387
74MAP3K110.57644454
75SGK10.57285935
76PRKCH0.54342980
77CAMK2B0.53333734
78SGK20.53254296
79DAPK30.52087170
80RAF10.48035804
81RPS6KA30.47894775
82PRKCE0.47793798
83MAPK100.47395632
84CDC42BPA0.47032931
85TNK20.46518734
86TAOK20.46180244
87ICK0.45735898
88CSNK1G10.45485466
89CAMK2D0.45137315
90CAMK1G0.44672472
91FER0.44375527
92ALK0.44037980
93CSNK1E0.43399332
94PKN10.43384573
95NEK60.42720171
96DMPK0.42700372
97PRKACA0.42409581
98BRSK10.41778891
99SIK30.41732152
100CDK30.40949951
101OXSR10.40730213
102STK160.40566526
103IRAK20.40232811
104PDK10.39720820
105CCNB10.39671104
106PRKCA0.39317700
107BCR0.39237486
108FRK0.38259811
109PRKG10.38089527
110FYN0.37645672
111MAP3K60.36916885
112CSNK1A10.36879496
113LIMK10.36869114
114MAPK80.36857500
115RPS6KA20.36360173
116MAP2K10.36100424
117CSNK1D0.35780219
118ROCK20.34044375
119SGK30.33593082
120PRKCB0.32634032
121MAPK90.32520886
122TRIM280.32300450
123MAPK120.31938958
124ERBB20.30202133
125PRKAA10.30078226
126GSK3B0.29977868

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.24218940
2Synaptic vesicle cycle_Homo sapiens_hsa047213.70626974
3GABAergic synapse_Homo sapiens_hsa047273.11155664
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95981838
5Morphine addiction_Homo sapiens_hsa050322.80633866
6Circadian entrainment_Homo sapiens_hsa047132.77600615
7Glutamatergic synapse_Homo sapiens_hsa047242.60783615
8Olfactory transduction_Homo sapiens_hsa047402.49589035
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42263732
10Insulin secretion_Homo sapiens_hsa049112.23094886
11Long-term potentiation_Homo sapiens_hsa047202.19550996
12Dopaminergic synapse_Homo sapiens_hsa047282.18526931
13Amphetamine addiction_Homo sapiens_hsa050312.15204212
14Salivary secretion_Homo sapiens_hsa049702.09764043
15Cholinergic synapse_Homo sapiens_hsa047252.03693138
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77160085
17Taste transduction_Homo sapiens_hsa047421.75007982
18Serotonergic synapse_Homo sapiens_hsa047261.71752458
19Gastric acid secretion_Homo sapiens_hsa049711.70882847
20Renin secretion_Homo sapiens_hsa049241.69713296
21Cocaine addiction_Homo sapiens_hsa050301.63722954
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63130933
23Oxytocin signaling pathway_Homo sapiens_hsa049211.59629303
24Long-term depression_Homo sapiens_hsa047301.55531703
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49689926
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46972006
27Collecting duct acid secretion_Homo sapiens_hsa049661.46812563
28Gap junction_Homo sapiens_hsa045401.42625079
29Calcium signaling pathway_Homo sapiens_hsa040201.42081269
30GnRH signaling pathway_Homo sapiens_hsa049121.31241648
31Vitamin B6 metabolism_Homo sapiens_hsa007501.29857365
32Phototransduction_Homo sapiens_hsa047441.29268868
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26771579
34Cardiac muscle contraction_Homo sapiens_hsa042601.24198819
35Axon guidance_Homo sapiens_hsa043601.23776572
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22065610
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17654435
38cAMP signaling pathway_Homo sapiens_hsa040241.13571339
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08791999
40Type II diabetes mellitus_Homo sapiens_hsa049301.07756000
41Estrogen signaling pathway_Homo sapiens_hsa049151.07202985
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06035772
43Circadian rhythm_Homo sapiens_hsa047101.05234114
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97664426
45Vibrio cholerae infection_Homo sapiens_hsa051100.97301643
46Melanogenesis_Homo sapiens_hsa049160.94573105
47Glioma_Homo sapiens_hsa052140.92935173
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92905549
49ErbB signaling pathway_Homo sapiens_hsa040120.91242319
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90281412
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84296075
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.82325279
53Pancreatic secretion_Homo sapiens_hsa049720.81380488
54Oocyte meiosis_Homo sapiens_hsa041140.77969053
55Thyroid hormone synthesis_Homo sapiens_hsa049180.75624987
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.72888486
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72630878
58Alcoholism_Homo sapiens_hsa050340.71107955
59Dilated cardiomyopathy_Homo sapiens_hsa054140.70730772
60Glucagon signaling pathway_Homo sapiens_hsa049220.67190067
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63923215
62Choline metabolism in cancer_Homo sapiens_hsa052310.63764565
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62882571
64MAPK signaling pathway_Homo sapiens_hsa040100.61710426
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60883505
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54216968
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54145322
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52472987
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51597246
70mTOR signaling pathway_Homo sapiens_hsa041500.50943821
71Ras signaling pathway_Homo sapiens_hsa040140.50844548
72Renal cell carcinoma_Homo sapiens_hsa052110.48979165
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.48119944
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.47526202
75Wnt signaling pathway_Homo sapiens_hsa043100.45932111
76Endometrial cancer_Homo sapiens_hsa052130.45812621
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45169677
78Alzheimers disease_Homo sapiens_hsa050100.44768411
79VEGF signaling pathway_Homo sapiens_hsa043700.44217841
80Prion diseases_Homo sapiens_hsa050200.43837211
81Bile secretion_Homo sapiens_hsa049760.41220798
82Endocytosis_Homo sapiens_hsa041440.40730471
83Dorso-ventral axis formation_Homo sapiens_hsa043200.40678135
84Rap1 signaling pathway_Homo sapiens_hsa040150.40148873
85Inositol phosphate metabolism_Homo sapiens_hsa005620.39399951
86Arginine and proline metabolism_Homo sapiens_hsa003300.39285406
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37673309
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.37309321
89Insulin signaling pathway_Homo sapiens_hsa049100.37033161
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36189147
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36182646
92Colorectal cancer_Homo sapiens_hsa052100.34984601
93Nitrogen metabolism_Homo sapiens_hsa009100.34403341
94Huntingtons disease_Homo sapiens_hsa050160.32231871
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31882542
96Type I diabetes mellitus_Homo sapiens_hsa049400.31003857
97Butanoate metabolism_Homo sapiens_hsa006500.30986435
98Hedgehog signaling pathway_Homo sapiens_hsa043400.30862188
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29758939
100Hippo signaling pathway_Homo sapiens_hsa043900.29296276
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27015798
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26869439
103Fatty acid biosynthesis_Homo sapiens_hsa000610.26493248
104Ovarian steroidogenesis_Homo sapiens_hsa049130.26269599
105Regulation of autophagy_Homo sapiens_hsa041400.26099441
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26084596
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26063956
108Oxidative phosphorylation_Homo sapiens_hsa001900.25931859
109Parkinsons disease_Homo sapiens_hsa050120.24224015
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24057677
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23500215
112Mineral absorption_Homo sapiens_hsa049780.21625730
113Ether lipid metabolism_Homo sapiens_hsa005650.20898557
114Tight junction_Homo sapiens_hsa045300.20488129
115beta-Alanine metabolism_Homo sapiens_hsa004100.18350558

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