IGSF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transmission of nerve impulse (GO:0051969)6.87901593
2negative regulation of neurological system process (GO:0031645)5.77868218
3aggressive behavior (GO:0002118)5.32965177
4cellular ketone body metabolic process (GO:0046950)4.81097428
5positive regulation of amino acid transport (GO:0051957)4.69410392
6negative regulation of cell size (GO:0045792)4.33657107
7RNA destabilization (GO:0050779)4.20974497
8ketone body metabolic process (GO:1902224)4.20895117
9regulation of female receptivity (GO:0045924)4.07868013
10xenobiotic catabolic process (GO:0042178)3.97941581
11negative regulation of protein oligomerization (GO:0032460)3.82146517
12response to pheromone (GO:0019236)3.67807941
13maternal behavior (GO:0042711)3.55229277
14regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.52048027
15positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.52048027
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.47493582
17parental behavior (GO:0060746)3.46578584
18nitric oxide mediated signal transduction (GO:0007263)3.44665765
19positive regulation of calcium ion import (GO:0090280)3.41540726
20regulation of hexokinase activity (GO:1903299)3.38021503
21regulation of glucokinase activity (GO:0033131)3.38021503
22nitric oxide biosynthetic process (GO:0006809)3.36985991
23Golgi to endosome transport (GO:0006895)3.35227306
24female mating behavior (GO:0060180)3.31452045
25interkinetic nuclear migration (GO:0022027)3.30603968
26zinc ion transmembrane transport (GO:0071577)3.28326342
27phosphatidylethanolamine biosynthetic process (GO:0006646)3.13323645
28sperm motility (GO:0030317)3.09333760
29zinc ion homeostasis (GO:0055069)2.99625430
30positive regulation of amine transport (GO:0051954)2.99001374
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98118893
32seminiferous tubule development (GO:0072520)2.94744194
33definitive hemopoiesis (GO:0060216)2.93930121
34mitochondrial calcium ion transport (GO:0006851)2.93295101
35regulation of skeletal muscle contraction (GO:0014819)2.92177822
36protein targeting to Golgi (GO:0000042)2.86972572
37insulin secretion (GO:0030073)2.86190979
38response to nitrosative stress (GO:0051409)2.85368315
39establishment of protein localization to Golgi (GO:0072600)2.84787256
40relaxation of cardiac muscle (GO:0055119)2.81380932
41regulation of glutamate secretion (GO:0014048)2.80293493
42regulation of type B pancreatic cell apoptotic process (GO:2000674)2.77126705
43regulation of feeding behavior (GO:0060259)2.75584757
44retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73471013
45fusion of sperm to egg plasma membrane (GO:0007342)2.71812687
46actin nucleation (GO:0045010)2.70340347
47phosphatidylethanolamine metabolic process (GO:0046337)2.69497028
48peptide hormone processing (GO:0016486)2.67470352
49regulation of vacuole organization (GO:0044088)2.66810962
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64553606
51acrosome reaction (GO:0007340)2.64477304
52cellular zinc ion homeostasis (GO:0006882)2.61848379
53sodium-independent organic anion transport (GO:0043252)2.61104339
54positive regulation of granulocyte differentiation (GO:0030854)2.58419061
55coenzyme catabolic process (GO:0009109)2.58015367
56positive regulation of mRNA catabolic process (GO:0061014)2.57542507
57axoneme assembly (GO:0035082)2.57081495
58protein K11-linked deubiquitination (GO:0035871)2.56558395
59Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56028003
60peroxisome fission (GO:0016559)2.54186075
61positive regulation of insulin secretion (GO:0032024)2.53929943
62drinking behavior (GO:0042756)2.53929153
63endocrine pancreas development (GO:0031018)2.53876583
64lactate metabolic process (GO:0006089)2.53275300
65positive regulation of peptide hormone secretion (GO:0090277)2.52445207
66negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51027253
67chemosensory behavior (GO:0007635)2.50753004
68organic cation transport (GO:0015695)2.50250393
69positive regulation of vascular permeability (GO:0043117)2.49329039
70positive regulation of organic acid transport (GO:0032892)2.48971352
71glycerophospholipid catabolic process (GO:0046475)2.48834098
72negative regulation of appetite (GO:0032099)2.48548455
73negative regulation of response to food (GO:0032096)2.48548455
74plasma membrane fusion (GO:0045026)2.45182402
75positive regulation of peptide secretion (GO:0002793)2.44296510
76dentate gyrus development (GO:0021542)2.43546519
77neuromuscular process controlling posture (GO:0050884)2.42317680
78calcium ion-dependent exocytosis (GO:0017156)2.42078104
79regulation of gamma-delta T cell differentiation (GO:0045586)2.41628240
80platelet dense granule organization (GO:0060155)2.40450913
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.39456225
82metallo-sulfur cluster assembly (GO:0031163)2.37925351
83iron-sulfur cluster assembly (GO:0016226)2.37925351
84regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.37773778
85protein polyglutamylation (GO:0018095)2.36573712
86keratinization (GO:0031424)2.35942637
87estrogen biosynthetic process (GO:0006703)2.34708140
88negative regulation of cation channel activity (GO:2001258)2.34571745
89inositol phosphate catabolic process (GO:0071545)2.32373610
90positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31799730
91epithelial cell fate commitment (GO:0072148)2.31584502
92peptidyl-threonine dephosphorylation (GO:0035970)2.31244756
93protein localization to Golgi apparatus (GO:0034067)2.30995052
94regulation of neurotransmitter uptake (GO:0051580)2.30901937
95phosphatidylserine acyl-chain remodeling (GO:0036150)2.30892646
96calcium ion import (GO:0070509)2.30865139
97intra-Golgi vesicle-mediated transport (GO:0006891)2.30307532
98protein lipidation (GO:0006497)2.30257105
99auditory receptor cell stereocilium organization (GO:0060088)2.30058074
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.30019807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.45952767
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.02833827
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39852491
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.30296449
5GBX2_23144817_ChIP-Seq_PC3_Human2.25878775
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08964894
7ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94778037
8IGF1R_20145208_ChIP-Seq_DFB_Human1.82814123
9IRF8_22096565_ChIP-ChIP_GC-B_Human1.78584812
10TAF15_26573619_Chip-Seq_HEK293_Human1.78108133
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75210002
12HTT_18923047_ChIP-ChIP_STHdh_Human1.74181570
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65178874
14DROSHA_22980978_ChIP-Seq_HELA_Human1.64846298
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61360625
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58946384
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57066260
18CBP_20019798_ChIP-Seq_JUKART_Human1.56618656
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56618656
20BCAT_22108803_ChIP-Seq_LS180_Human1.53756411
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48396433
22SCL_19346495_ChIP-Seq_HPC-7_Human1.46857817
23SMAD4_21799915_ChIP-Seq_A2780_Human1.45084326
24FUS_26573619_Chip-Seq_HEK293_Human1.44183161
25REST_21632747_ChIP-Seq_MESCs_Mouse1.42223436
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40305127
27* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.40156151
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40075374
29ZNF274_21170338_ChIP-Seq_K562_Hela1.38167321
30MYC_19829295_ChIP-Seq_ESCs_Human1.37914852
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30012317
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.29543961
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29543961
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29218110
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27756130
36VDR_22108803_ChIP-Seq_LS180_Human1.27410859
37P300_19829295_ChIP-Seq_ESCs_Human1.24516006
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22898195
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20888828
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.20000542
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19915234
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19915234
43ER_23166858_ChIP-Seq_MCF-7_Human1.19364760
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19064208
45AR_25329375_ChIP-Seq_VCAP_Human1.18248612
46CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16978944
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15247890
48STAT3_23295773_ChIP-Seq_U87_Human1.13887169
49NANOG_20526341_ChIP-Seq_ESCs_Human1.13689076
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.13257206
51TCF4_23295773_ChIP-Seq_U87_Human1.13174864
52TP53_22573176_ChIP-Seq_HFKS_Human1.11390404
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.10049591
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09472023
55GATA3_26560356_Chip-Seq_TH2_Human1.09451320
56* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07749758
57NCOR_22424771_ChIP-Seq_293T_Human1.07163795
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07126718
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06818918
60AR_20517297_ChIP-Seq_VCAP_Human1.06176659
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.05916429
62SOX2_19829295_ChIP-Seq_ESCs_Human1.03905255
63NANOG_19829295_ChIP-Seq_ESCs_Human1.03905255
64TCF4_22108803_ChIP-Seq_LS180_Human1.03073193
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.03004516
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02635041
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.02383748
68ERA_21632823_ChIP-Seq_H3396_Human1.01844698
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.01232196
70* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01058319
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.00701913
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00566535
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00028022
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99397544
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99366002
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98172541
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96150011
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96103148
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95995763
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95171215
81SMAD4_21741376_ChIP-Seq_EPCs_Human0.94524814
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94399954
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93689841
84ERG_20517297_ChIP-Seq_VCAP_Human0.92778008
85STAT1_17558387_ChIP-Seq_HELA_Human0.92733037
86GATA3_26560356_Chip-Seq_TH1_Human0.92432871
87SMRT_27268052_Chip-Seq_Bcells_Human0.92019823
88MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92001360
89STAT3_18555785_Chip-Seq_ESCs_Mouse0.91489588
90* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91195609
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91118126
92CDX2_22108803_ChIP-Seq_LS180_Human0.90942001
93NFYB_21822215_ChIP-Seq_K562_Human0.90865396
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.89898250
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.89436693
96P300_27268052_Chip-Seq_Bcells_Human0.89260420
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89137613
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88900182
99GATA3_27048872_Chip-Seq_THYMUS_Human0.88774906
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88455162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.73762321
2MP0003195_calcinosis3.56942348
3MP0002822_catalepsy3.25255222
4MP0002837_dystrophic_cardiac_calcinosis3.10068400
5MP0005646_abnormal_pituitary_gland2.79633196
6MP0003787_abnormal_imprinting2.74472788
7MP0002638_abnormal_pupillary_reflex2.34929269
8MP0005410_abnormal_fertilization2.33252932
9MP0002693_abnormal_pancreas_physiology2.21662613
10MP0009046_muscle_twitch2.19198756
11MP0008877_abnormal_DNA_methylation2.16782858
12MP0008004_abnormal_stomach_pH2.05005103
13MP0004043_abnormal_pH_regulation1.98606062
14MP0003122_maternal_imprinting1.83188311
15MP0009840_abnormal_foam_cell1.82499499
16MP0006072_abnormal_retinal_apoptosis1.76784802
17MP0005379_endocrine/exocrine_gland_phen1.65939099
18MP0001968_abnormal_touch/_nociception1.65801657
19MP0008872_abnormal_physiological_respon1.64748000
20MP0005084_abnormal_gallbladder_morpholo1.63856577
21MP0010386_abnormal_urinary_bladder1.59019131
22MP0001986_abnormal_taste_sensitivity1.58415631
23MP0000013_abnormal_adipose_tissue1.48911846
24MP0005058_abnormal_lysosome_morphology1.46107775
25MP0009278_abnormal_bone_marrow1.43075382
26MP0002909_abnormal_adrenal_gland1.42591795
27MP0000465_gastrointestinal_hemorrhage1.42425714
28MP0001944_abnormal_pancreas_morphology1.41442668
29MP0009745_abnormal_behavioral_response1.39118322
30MP0003879_abnormal_hair_cell1.36778753
31MP0001545_abnormal_hematopoietic_system1.35265668
32MP0005397_hematopoietic_system_phenotyp1.35265668
33MP0002653_abnormal_ependyma_morphology1.33176193
34MP0005464_abnormal_platelet_physiology1.32461650
35MP0002277_abnormal_respiratory_mucosa1.29732204
36MP0002064_seizures1.29728103
37MP0002166_altered_tumor_susceptibility1.28650675
38MP0002078_abnormal_glucose_homeostasis1.27926185
39MP0002733_abnormal_thermal_nociception1.24486223
40MP0001970_abnormal_pain_threshold1.22992155
41MP0000569_abnormal_digit_pigmentation1.22687008
42MP0010234_abnormal_vibrissa_follicle1.22054266
43MP0001501_abnormal_sleep_pattern1.21590826
44MP0004085_abnormal_heartbeat1.21065027
45MP0005167_abnormal_blood-brain_barrier1.20314610
46MP0005448_abnormal_energy_balance1.19811472
47MP0004885_abnormal_endolymph1.19291901
48MP0005671_abnormal_response_to1.18483510
49MP0002272_abnormal_nervous_system1.15746476
50MP0003011_delayed_dark_adaptation1.12500610
51MP0000516_abnormal_urinary_system1.10735015
52MP0005367_renal/urinary_system_phenotyp1.10735015
53MP0001756_abnormal_urination1.10676932
54MP0003878_abnormal_ear_physiology1.09321101
55MP0005377_hearing/vestibular/ear_phenot1.09321101
56MP0002572_abnormal_emotion/affect_behav1.08269084
57MP0005253_abnormal_eye_physiology1.06522087
58MP0005551_abnormal_eye_electrophysiolog1.06168460
59MP0001486_abnormal_startle_reflex1.03882816
60MP0001984_abnormal_olfaction1.03588743
61MP0000230_abnormal_systemic_arterial1.03121718
62MP0005535_abnormal_body_temperature1.02903400
63MP0001502_abnormal_circadian_rhythm1.02677659
64MP0003698_abnormal_male_reproductive1.01242635
65MP0001765_abnormal_ion_homeostasis0.99590470
66MP0003953_abnormal_hormone_level0.98705823
67MP0006036_abnormal_mitochondrial_physio0.94361020
68MP0003633_abnormal_nervous_system0.93704191
69MP0002928_abnormal_bile_duct0.92712565
70MP0006276_abnormal_autonomic_nervous0.92075100
71MP0006082_CNS_inflammation0.91955477
72MP0005636_abnormal_mineral_homeostasis0.89654564
73MP0010329_abnormal_lipoprotein_level0.89169085
74MP0002229_neurodegeneration0.88768086
75MP0005220_abnormal_exocrine_pancreas0.86490862
76MP0001905_abnormal_dopamine_level0.85240893
77MP0004142_abnormal_muscle_tone0.85182115
78MP0005387_immune_system_phenotype0.83579610
79MP0001790_abnormal_immune_system0.83579610
80MP0002557_abnormal_social/conspecific_i0.81285057
81MP0002118_abnormal_lipid_homeostasis0.80293773
82MP0005451_abnormal_body_composition0.78212973
83MP0003283_abnormal_digestive_organ0.78136501
84MP0009643_abnormal_urine_homeostasis0.77405965
85MP0001929_abnormal_gametogenesis0.76776766
86MP0004742_abnormal_vestibular_system0.76656131
87MP0001485_abnormal_pinna_reflex0.75066081
88MP0003635_abnormal_synaptic_transmissio0.74071025
89MP0002067_abnormal_sensory_capabilities0.73817046
90MP0001664_abnormal_digestion0.73021157
91MP0005332_abnormal_amino_acid0.70717577
92MP0005174_abnormal_tail_pigmentation0.70363590
93MP0005075_abnormal_melanosome_morpholog0.70041546
94MP0002132_abnormal_respiratory_system0.69963319
95MP0005310_abnormal_salivary_gland0.69470675
96MP0010678_abnormal_skin_adnexa0.69455383
97MP0003121_genomic_imprinting0.69426835
98MP0002971_abnormal_brown_adipose0.69391544
99MP0002090_abnormal_vision0.69332074
100MP0001873_stomach_inflammation0.68788603

Predicted human phenotypes

RankGene SetZ-score
1Ketoacidosis (HP:0001993)5.69315515
2Large for gestational age (HP:0001520)4.59573863
3Ketosis (HP:0001946)3.95531285
4Hypoglycemic seizures (HP:0002173)3.79573974
5Abnormal rod and cone electroretinograms (HP:0008323)3.75115597
6Insulin-resistant diabetes mellitus (HP:0000831)3.50779234
7Hypothermia (HP:0002045)3.41392430
8Increased circulating renin level (HP:0000848)3.32192898
9Abnormal drinking behavior (HP:0030082)3.18375938
10Polydipsia (HP:0001959)3.18375938
11Hyperinsulinemic hypoglycemia (HP:0000825)3.09618206
12Hypoglycemic coma (HP:0001325)2.96377347
13Hyperglycemia (HP:0003074)2.92303665
14Stomatitis (HP:0010280)2.80967870
15Decreased circulating renin level (HP:0003351)2.77952163
16Vacuolated lymphocytes (HP:0001922)2.51467653
17Polyuria (HP:0000103)2.49250263
18Progressive cerebellar ataxia (HP:0002073)2.49176781
19Failure to thrive in infancy (HP:0001531)2.44383405
20Methylmalonic aciduria (HP:0012120)2.42614110
21Metaphyseal dysplasia (HP:0100255)2.41371907
22Increased CSF protein (HP:0002922)2.37817839
23Tubulointerstitial nephritis (HP:0001970)2.36631082
24Hyperthyroidism (HP:0000836)2.35193872
25Congenital stationary night blindness (HP:0007642)2.31712760
26Hypokalemia (HP:0002900)2.29907627
27Abnormality of macular pigmentation (HP:0008002)2.29305099
28Attenuation of retinal blood vessels (HP:0007843)2.28147995
29Hypomagnesemia (HP:0002917)2.25940846
30Febrile seizures (HP:0002373)2.25357068
31Abnormality of renin-angiotensin system (HP:0000847)2.24129565
32Methylmalonic acidemia (HP:0002912)2.23246698
33Hyperventilation (HP:0002883)2.22474162
34Abnormality of potassium homeostasis (HP:0011042)2.19889108
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14706413
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13511708
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.12430421
38Calf muscle hypertrophy (HP:0008981)2.11577566
39Congenital malformation of the right heart (HP:0011723)2.10165677
40Double outlet right ventricle (HP:0001719)2.10165677
41Gaze-evoked nystagmus (HP:0000640)2.09656479
42Poor suck (HP:0002033)2.08303397
43Abnormal urine output (HP:0012590)2.08073603
44Intestinal atresia (HP:0011100)2.07601081
45Dysautonomia (HP:0002459)2.06922047
46Polyphagia (HP:0002591)2.06028451
47Bony spicule pigmentary retinopathy (HP:0007737)2.04404884
48Conjunctival hamartoma (HP:0100780)2.04326609
49Symptomatic seizures (HP:0011145)2.00974203
50Congenital sensorineural hearing impairment (HP:0008527)1.97228732
51Abnormality of the renal cortex (HP:0011035)1.96965578
52Abnormality of liposaccharide metabolism (HP:0010968)1.96485725
53Abnormality of glycosphingolipid metabolism (HP:0004343)1.96485725
54Abnormality of glycolipid metabolism (HP:0010969)1.96485725
55Increased neuronal autofluorescent lipopigment (HP:0002074)1.96092945
56Abnormality of endocrine pancreas physiology (HP:0012093)1.93298532
57Abnormality of the pancreatic islet cells (HP:0006476)1.93298532
58Increased cerebral lipofuscin (HP:0011813)1.90835298
59EEG with generalized epileptiform discharges (HP:0011198)1.90629057
60Hyperkalemia (HP:0002153)1.90508559
61Abnormality of vitamin B metabolism (HP:0004340)1.89952217
62Menstrual irregularities (HP:0000858)1.89138019
63Abnormality of renal excretion (HP:0011036)1.88565580
64Postural tremor (HP:0002174)1.87011794
65Epileptiform EEG discharges (HP:0011182)1.86466546
66Abolished electroretinogram (ERG) (HP:0000550)1.85936229
67Hematochezia (HP:0002573)1.83104243
68Asymmetric septal hypertrophy (HP:0001670)1.81278254
69Muscle hypertrophy of the lower extremities (HP:0008968)1.81144743
70Oligomenorrhea (HP:0000876)1.80736997
71Tachypnea (HP:0002789)1.80271476
72Neoplasm of the adrenal cortex (HP:0100641)1.79036298
73Abnormal eating behavior (HP:0100738)1.78869616
74Abnormality of the fovea (HP:0000493)1.78853492
75Hypsarrhythmia (HP:0002521)1.78324318
76Type I diabetes mellitus (HP:0100651)1.78211806
77Hemiparesis (HP:0001269)1.77512474
78Testicular neoplasm (HP:0010788)1.75342122
79Renal cortical cysts (HP:0000803)1.73780574
80Gait imbalance (HP:0002141)1.73509807
81Neuroendocrine neoplasm (HP:0100634)1.71392898
82Abnormality of fatty-acid metabolism (HP:0004359)1.70191102
83Aqueductal stenosis (HP:0002410)1.69242897
84Fair hair (HP:0002286)1.69011027
85Palmoplantar hyperkeratosis (HP:0000972)1.68326658
86Elevated erythrocyte sedimentation rate (HP:0003565)1.67872919
87Congenital primary aphakia (HP:0007707)1.67630532
88Episodic fever (HP:0001954)1.67503545
89Hyperaldosteronism (HP:0000859)1.66833501
90Impaired smooth pursuit (HP:0007772)1.65572756
91Generalized aminoaciduria (HP:0002909)1.65335633
92Sensory axonal neuropathy (HP:0003390)1.64795179
93Progressive microcephaly (HP:0000253)1.63528453
94Bradycardia (HP:0001662)1.63019998
95Resting tremor (HP:0002322)1.62888136
96Prolonged bleeding time (HP:0003010)1.62314390
97Dicarboxylic aciduria (HP:0003215)1.61673114
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61673114
99Basal ganglia calcification (HP:0002135)1.61450335
100Medial flaring of the eyebrow (HP:0010747)1.60633829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.61027065
2TESK13.18996421
3MAP3K112.77922256
4MAP4K22.61307127
5DAPK22.48328124
6MAP4K12.42842643
7PIK3CG2.35464026
8TNK22.15986852
9TXK2.13161968
10TAOK32.11796056
11MAP3K21.91818547
12TRPM71.74179067
13GRK11.54755458
14PHKG11.53736848
15PHKG21.53736848
16BLK1.53192225
17TESK21.50682165
18INSRR1.46581606
19PRKG21.42522075
20HIPK21.41762405
21FGFR21.41600246
22MAPKAPK31.38522692
23MAP3K131.34747393
24PINK11.33239910
25STK381.28285427
26LIMK11.25678318
27NTRK31.25436838
28CAMKK21.22634501
29MST41.20782156
30CSNK1G11.20416523
31ZAK1.18575442
32PIM21.11264207
33FES1.09409336
34PRKD21.08201621
35OXSR11.06872956
36DYRK1B1.06173146
37CSNK1G31.06021510
38MAP2K61.02380961
39NLK1.01369252
40CSNK1G20.98904215
41TEC0.97296415
42MAP3K10.96794469
43ADRBK20.96339939
44STK390.95814498
45FGFR30.95104828
46MAP2K70.94337668
47PDK10.93973777
48PNCK0.93567365
49PRKCE0.91754361
50KDR0.88155165
51MAP3K70.86490534
52OBSCN0.85465833
53PRKAA20.85201492
54CAMK10.85153558
55NUAK10.84413271
56ARAF0.84072417
57ITK0.83722395
58FER0.83245895
59MAP3K90.82628873
60CSNK1A1L0.82450595
61MAP2K20.80186574
62BTK0.80160330
63AKT30.78559975
64MAPK130.77708571
65PTK2B0.76976275
66PRKCG0.76773432
67PDPK10.73817139
68VRK10.73116639
69BRD40.66521534
70TLK10.66035123
71ABL20.64171871
72SYK0.63693481
73GRK50.63564110
74PLK20.62885508
75STK110.61148817
76MAPK150.59458976
77CDK30.58835178
78PRKCQ0.56836145
79PRKAA10.56835083
80CSNK1A10.56020165
81CAMK1D0.55652715
82JAK30.54302707
83BMPR20.52628923
84MAPKAPK50.52343405
85CAMK1G0.51474367
86ERBB30.50899083
87FGR0.48876783
88DAPK30.48300701
89IKBKB0.47759050
90PLK40.47348655
91RPS6KA50.46284688
92RPS6KB10.45846742
93MAPK110.45157105
94CSNK1D0.44969522
95PRKD10.43923017
96MAP3K40.43791336
97PRKCA0.43727228
98PRKG10.41547270
99PIM10.41346727
100PASK0.40915586

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.40489374
2Butanoate metabolism_Homo sapiens_hsa006503.13933484
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85644800
4Insulin secretion_Homo sapiens_hsa049112.32752122
5Regulation of autophagy_Homo sapiens_hsa041402.31514897
6Circadian rhythm_Homo sapiens_hsa047102.23615267
7Olfactory transduction_Homo sapiens_hsa047402.22346953
8Phototransduction_Homo sapiens_hsa047442.12755871
9Type I diabetes mellitus_Homo sapiens_hsa049402.01796358
10Renin secretion_Homo sapiens_hsa049241.80673613
11Fatty acid elongation_Homo sapiens_hsa000621.80649719
12Circadian entrainment_Homo sapiens_hsa047131.75564309
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65805844
14Peroxisome_Homo sapiens_hsa041461.57670659
15Synaptic vesicle cycle_Homo sapiens_hsa047211.55525411
16ABC transporters_Homo sapiens_hsa020101.53260623
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.52829611
18Salivary secretion_Homo sapiens_hsa049701.50879673
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50821598
20Collecting duct acid secretion_Homo sapiens_hsa049661.49051275
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.37369711
22Caffeine metabolism_Homo sapiens_hsa002321.34733622
23Lysosome_Homo sapiens_hsa041421.31025978
24Ether lipid metabolism_Homo sapiens_hsa005651.29111129
25Primary immunodeficiency_Homo sapiens_hsa053401.29081549
26Nitrogen metabolism_Homo sapiens_hsa009101.28107165
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24804977
28Oxidative phosphorylation_Homo sapiens_hsa001901.21584530
29Amphetamine addiction_Homo sapiens_hsa050311.19817970
30Sphingolipid metabolism_Homo sapiens_hsa006001.19574320
31Nicotine addiction_Homo sapiens_hsa050331.18449515
32Tryptophan metabolism_Homo sapiens_hsa003801.17168737
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15351555
34Linoleic acid metabolism_Homo sapiens_hsa005911.12828715
35GABAergic synapse_Homo sapiens_hsa047271.11679999
36Morphine addiction_Homo sapiens_hsa050321.10306506
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08224827
38Long-term depression_Homo sapiens_hsa047301.08015206
39Type II diabetes mellitus_Homo sapiens_hsa049301.07766820
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07097332
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06083606
42Taste transduction_Homo sapiens_hsa047421.03628272
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01188075
44Gastric acid secretion_Homo sapiens_hsa049710.97494460
45Glucagon signaling pathway_Homo sapiens_hsa049220.97402498
46Arachidonic acid metabolism_Homo sapiens_hsa005900.93497230
47Vitamin B6 metabolism_Homo sapiens_hsa007500.91215442
48Other glycan degradation_Homo sapiens_hsa005110.90366798
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88590663
50Glutamatergic synapse_Homo sapiens_hsa047240.87708248
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87531378
52Serotonergic synapse_Homo sapiens_hsa047260.87199131
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86817683
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86683907
55Dorso-ventral axis formation_Homo sapiens_hsa043200.84322934
56Ovarian steroidogenesis_Homo sapiens_hsa049130.82777314
57Inositol phosphate metabolism_Homo sapiens_hsa005620.81957421
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81101412
59Chemical carcinogenesis_Homo sapiens_hsa052040.80904636
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80763240
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80602478
62Oxytocin signaling pathway_Homo sapiens_hsa049210.79005113
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.78938269
64Dopaminergic synapse_Homo sapiens_hsa047280.77471799
65Antigen processing and presentation_Homo sapiens_hsa046120.76840465
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.76242850
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72553293
68Mineral absorption_Homo sapiens_hsa049780.71386432
69Fructose and mannose metabolism_Homo sapiens_hsa000510.70733529
70Calcium signaling pathway_Homo sapiens_hsa040200.70351012
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69784409
72Fatty acid degradation_Homo sapiens_hsa000710.69276380
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68437241
74cAMP signaling pathway_Homo sapiens_hsa040240.67373328
75Pancreatic secretion_Homo sapiens_hsa049720.63350606
76Fatty acid metabolism_Homo sapiens_hsa012120.62561491
77Rheumatoid arthritis_Homo sapiens_hsa053230.61545890
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61095794
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60617759
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59667736
81Platelet activation_Homo sapiens_hsa046110.58306545
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.55297573
83Long-term potentiation_Homo sapiens_hsa047200.52293356
84Propanoate metabolism_Homo sapiens_hsa006400.50019541
85Vibrio cholerae infection_Homo sapiens_hsa051100.49339101
86Retinol metabolism_Homo sapiens_hsa008300.48029541
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.46491577
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44870029
89Arginine biosynthesis_Homo sapiens_hsa002200.42384315
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41796032
91Alzheimers disease_Homo sapiens_hsa050100.41747075
92Parkinsons disease_Homo sapiens_hsa050120.41387671
93Glutathione metabolism_Homo sapiens_hsa004800.40965555
94Asthma_Homo sapiens_hsa053100.37607406
95Glycerolipid metabolism_Homo sapiens_hsa005610.36189009
96GnRH signaling pathway_Homo sapiens_hsa049120.35121473
97Autoimmune thyroid disease_Homo sapiens_hsa053200.33558157
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32401688
99Protein export_Homo sapiens_hsa030600.32126995
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31908510

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