IGSF23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)9.09528866
2angiotensin maturation (GO:0002003)8.56646664
3negative regulation of fibrinolysis (GO:0051918)7.70633123
4regulation of fibrinolysis (GO:0051917)7.05816341
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.97728756
6L-phenylalanine catabolic process (GO:0006559)6.97728756
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.43104075
8L-phenylalanine metabolic process (GO:0006558)6.43104075
9phenylpropanoid metabolic process (GO:0009698)6.25279722
10vitamin A metabolic process (GO:0006776)6.22610317
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03600089
12peptidyl-glutamic acid carboxylation (GO:0017187)6.03268586
13protein carboxylation (GO:0018214)6.03268586
14regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.92133674
15cellular glucuronidation (GO:0052695)5.87532305
16regulation of protein activation cascade (GO:2000257)5.78585214
17positive regulation of triglyceride lipase activity (GO:0061365)5.67719463
18positive regulation of lipoprotein lipase activity (GO:0051006)5.67719463
19uronic acid metabolic process (GO:0006063)5.64928251
20glucuronate metabolic process (GO:0019585)5.64928251
21serine family amino acid catabolic process (GO:0009071)5.62964207
22epoxygenase P450 pathway (GO:0019373)5.60473621
23fibrinolysis (GO:0042730)5.57317101
24phospholipid efflux (GO:0033700)5.38049471
25regulation of cholesterol esterification (GO:0010872)5.36483734
26digestion (GO:0007586)5.31958885
27regulation of triglyceride catabolic process (GO:0010896)5.24152967
28exogenous drug catabolic process (GO:0042738)5.10454815
29regulation of complement activation (GO:0030449)5.08017333
30drug catabolic process (GO:0042737)5.02626488
31regulation of lipoprotein particle clearance (GO:0010984)5.01103903
32negative regulation of lipase activity (GO:0060192)5.00784146
33glycine metabolic process (GO:0006544)4.97447731
34plasma lipoprotein particle assembly (GO:0034377)4.93656254
35digestive system process (GO:0022600)4.92788185
36blood coagulation, intrinsic pathway (GO:0007597)4.81069936
37complement activation, alternative pathway (GO:0006957)4.80895916
38bile acid metabolic process (GO:0008206)4.74680549
39protein-lipid complex assembly (GO:0065005)4.69152966
40regulation of plasminogen activation (GO:0010755)4.67786030
41flavonoid metabolic process (GO:0009812)4.67130632
42bile acid biosynthetic process (GO:0006699)4.65867146
43plasma lipoprotein particle clearance (GO:0034381)4.65150825
44oxidative demethylation (GO:0070989)4.61090152
45negative regulation of fatty acid biosynthetic process (GO:0045717)4.54062346
46negative regulation of blood coagulation (GO:0030195)4.44379082
47negative regulation of hemostasis (GO:1900047)4.44379082
48aromatic amino acid family catabolic process (GO:0009074)4.42928050
49adhesion of symbiont to host cell (GO:0044650)4.42848831
50virion attachment to host cell (GO:0019062)4.42848831
51intestinal epithelial cell development (GO:0060576)4.36299784
52heme transport (GO:0015886)4.35119932
53actin filament depolymerization (GO:0030042)4.28973859
54modified amino acid transport (GO:0072337)4.26372921
55lipoprotein metabolic process (GO:0042157)4.25799498
56serine family amino acid metabolic process (GO:0009069)4.23340832
57alkaloid metabolic process (GO:0009820)4.22409947
58cholesterol efflux (GO:0033344)4.21081578
59bundle of His cell to Purkinje myocyte communication (GO:0086069)4.16324055
60purine nucleotide salvage (GO:0032261)4.15029897
61drug transmembrane transport (GO:0006855)4.14570612
62negative regulation of coagulation (GO:0050819)4.08893226
63hormone catabolic process (GO:0042447)4.08355655
64regulation of bile acid biosynthetic process (GO:0070857)4.06022138
65daunorubicin metabolic process (GO:0044597)4.02688885
66polyketide metabolic process (GO:0030638)4.02688885
67doxorubicin metabolic process (GO:0044598)4.02688885
68proline metabolic process (GO:0006560)4.02461007
69peptide catabolic process (GO:0043171)4.02282743
70negative regulation of sterol transport (GO:0032372)3.98550239
71negative regulation of cholesterol transport (GO:0032375)3.98550239
72negative regulation of wound healing (GO:0061045)3.94337051
73diacylglycerol metabolic process (GO:0046339)3.88760473
74glucose 6-phosphate metabolic process (GO:0051156)3.85267311
75reverse cholesterol transport (GO:0043691)3.84521894
76omega-hydroxylase P450 pathway (GO:0097267)3.84122897
77very-low-density lipoprotein particle assembly (GO:0034379)3.84049761
78cholesterol homeostasis (GO:0042632)3.78910674
79sterol homeostasis (GO:0055092)3.74219890
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.73723498
81positive regulation of blood coagulation (GO:0030194)3.71401539
82positive regulation of hemostasis (GO:1900048)3.71401539
83positive regulation of fatty acid biosynthetic process (GO:0045723)3.71141514
84negative regulation of protein activation cascade (GO:2000258)3.70204107
85sterol transport (GO:0015918)3.67908564
86cholesterol transport (GO:0030301)3.67908564
87steroid catabolic process (GO:0006706)3.62756174
88adhesion of symbiont to host (GO:0044406)3.62646616
89high-density lipoprotein particle remodeling (GO:0034375)3.60785709
90plasma lipoprotein particle remodeling (GO:0034369)3.60338787
91protein-lipid complex remodeling (GO:0034368)3.60338787
92macromolecular complex remodeling (GO:0034367)3.60338787
93positive regulation of lipid catabolic process (GO:0050996)3.59419950
94aminoglycoside antibiotic metabolic process (GO:0030647)3.58329962
95protein activation cascade (GO:0072376)3.57124147
96arginine metabolic process (GO:0006525)3.56245238
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.56204574
98purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.56204574
99low-density lipoprotein particle remodeling (GO:0034374)3.55394437
100drug transport (GO:0015893)3.50890567
101serine family amino acid biosynthetic process (GO:0009070)3.49240385
102negative regulation of thymocyte apoptotic process (GO:0070244)3.46374952
103positive regulation of coagulation (GO:0050820)3.46318295
104fat-soluble vitamin biosynthetic process (GO:0042362)3.45308733
105UDP-N-acetylglucosamine metabolic process (GO:0006047)3.45229796
106negative regulation of digestive system process (GO:0060457)3.43558081
107positive regulation of T cell differentiation in thymus (GO:0033089)3.42241064
108aldehyde catabolic process (GO:0046185)3.42078515
109amino-acid betaine metabolic process (GO:0006577)3.36784217
110positive regulation of triglyceride metabolic process (GO:0090208)3.30287313
111response to hydroperoxide (GO:0033194)3.29302159
112acetyl-CoA metabolic process (GO:0006084)3.28774833
113tyrosine metabolic process (GO:0006570)3.28431349
114plasma lipoprotein particle organization (GO:0071827)3.27953223
115sulfate transmembrane transport (GO:1902358)3.27659424
116acute-phase response (GO:0006953)3.25700234
117urea metabolic process (GO:0019627)3.24905778
118urea cycle (GO:0000050)3.24905778
119protein-lipid complex subunit organization (GO:0071825)3.24416026
120positive regulation of cellular amine metabolic process (GO:0033240)3.23504557
121sulfation (GO:0051923)3.20566439
122maintenance of gastrointestinal epithelium (GO:0030277)3.20055460
123transcytosis (GO:0045056)3.19323209
124bile acid and bile salt transport (GO:0015721)3.15330232
125regulation of Golgi to plasma membrane protein transport (GO:0042996)3.15141674
126cellular response to hepatocyte growth factor stimulus (GO:0035729)3.13064170
127response to hepatocyte growth factor (GO:0035728)3.13064170
128nucleotide salvage (GO:0043173)3.11235093
129innate immune response in mucosa (GO:0002227)3.07274146
130regulation of cholesterol homeostasis (GO:2000188)3.06253339
131peptide hormone processing (GO:0016486)3.06093684
132drinking behavior (GO:0042756)3.02912528
133NADH metabolic process (GO:0006734)3.00398466
134regulation of digestive system process (GO:0044058)2.96263305
135sulfur compound transport (GO:0072348)2.95346328
136cysteine metabolic process (GO:0006534)2.91748836
137lipoprotein transport (GO:0042953)2.91213962
138purine nucleobase biosynthetic process (GO:0009113)2.88752273
139nitrogen cycle metabolic process (GO:0071941)2.88220106
140trophectodermal cell differentiation (GO:0001829)2.84618675
141phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82131727
142hepatocyte apoptotic process (GO:0097284)2.77637997
143sulfate transport (GO:0008272)2.77225655
144thyroid hormone metabolic process (GO:0042403)2.76300096
145regulation of RIG-I signaling pathway (GO:0039535)2.75750590
146mucosal immune response (GO:0002385)2.74272563
147homocysteine metabolic process (GO:0050667)2.73529924
148regulation of cytokine secretion involved in immune response (GO:0002739)2.71349011
149drug metabolic process (GO:0017144)2.70650334
150mucosal-associated lymphoid tissue development (GO:0048537)2.69564155
151Peyers patch development (GO:0048541)2.69564155
152oligosaccharide catabolic process (GO:0009313)2.69486074
153regulation of sterol transport (GO:0032371)2.68751123
154regulation of cholesterol transport (GO:0032374)2.68751123
155L-alpha-amino acid transmembrane transport (GO:1902475)2.68540481
156acylglycerol homeostasis (GO:0055090)2.65456371
157triglyceride homeostasis (GO:0070328)2.65456371
158regulation of lipoprotein metabolic process (GO:0050746)2.64809905
159COPII vesicle coating (GO:0048208)2.64540928
160proline biosynthetic process (GO:0006561)2.64285796
161purine deoxyribonucleotide catabolic process (GO:0009155)2.62698028
162transepithelial transport (GO:0070633)2.60860481
163intestinal cholesterol absorption (GO:0030299)11.8332706
164intestinal absorption (GO:0050892)11.5643065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.50900973
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.81293205
3E2F7_22180533_ChIP-Seq_HELA_Human3.56736918
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.55883027
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.21135887
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07718267
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.02004291
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.90068126
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.72968401
10GATA4_25053715_ChIP-Seq_YYC3_Human2.63373908
11GATA6_25053715_ChIP-Seq_YYC3_Human2.58505511
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42460639
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.34669321
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.25102150
15* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24935644
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16329520
17AR_21909140_ChIP-Seq_LNCAP_Human2.14799121
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.06974817
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88491771
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.87028976
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86516772
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83872391
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81170465
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80586898
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80396324
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76935918
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72128876
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70026623
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67697498
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62303093
31ATF3_27146783_Chip-Seq_COLON_Human1.57641545
32SOX2_20726797_ChIP-Seq_SW620_Human1.55183178
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53116215
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53032514
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50677081
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50446156
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42737433
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40848314
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39380327
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38599514
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36499375
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36340737
43HNFA_21074721_ChIP-Seq_CACO-2_Human1.35518203
44EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.35442287
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34192892
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.33216823
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33156582
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31600773
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30096851
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28384326
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25802916
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24253536
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23125347
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22802103
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.21967795
56SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20501117
57CEBPB_22108803_ChIP-Seq_LS180_Human1.20374141
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20081965
59MYC_22102868_ChIP-Seq_BL_Human1.19945250
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19905080
61PHF8_20622853_ChIP-Seq_HELA_Human1.19731435
62ER_23166858_ChIP-Seq_MCF-7_Human1.18167636
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18079874
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.17870865
65HNF4A_19822575_ChIP-Seq_HepG2_Human1.17269295
66RACK7_27058665_Chip-Seq_MCF-7_Human1.16429089
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.15930480
68RBPJ_21746931_ChIP-Seq_IB4_Human1.15584747
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.13650869
70GATA1_22025678_ChIP-Seq_K562_Human1.13049340
71UTX_26944678_Chip-Seq_JUKART_Human1.12806815
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12493300
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12483052
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11029892
75CBP_20019798_ChIP-Seq_JUKART_Human1.11029892
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10860013
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09423700
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.09020896
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08300676
80ETV1_20927104_ChIP-Seq_GIST48_Human1.07706736
81RAC3_21632823_ChIP-Seq_H3396_Human1.07354012
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07214539
83KAP1_27257070_Chip-Seq_ESCs_Mouse1.05842019
84TP53_18474530_ChIP-ChIP_U2OS_Human1.05451380
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05444581
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05194982
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.03919315
88NFYA_21822215_ChIP-Seq_K562_Human1.03828960
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03047577
90SOX2_21211035_ChIP-Seq_LN229_Human1.03020730
91CTCF_27219007_Chip-Seq_Bcells_Human1.02795230
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02671924
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.02364600
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02116970
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02046973
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00765206
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98559755
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98121730
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98051734
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.96834165
101P53_21459846_ChIP-Seq_SAOS-2_Human0.96141032
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95840506
103PHF8_20622854_ChIP-Seq_HELA_Human0.95699215
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93939388
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93218756
106MYC_19829295_ChIP-Seq_ESCs_Human0.93133604
107BCOR_27268052_Chip-Seq_Bcells_Human0.93066411
108MYC_18940864_ChIP-ChIP_HL60_Human0.92902027
109P68_20966046_ChIP-Seq_HELA_Human0.92611466
110BCL6_27268052_Chip-Seq_Bcells_Human0.92273693
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92048949
112ERA_21632823_ChIP-Seq_H3396_Human0.91778158
113ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91761286
114KLF5_25053715_ChIP-Seq_YYC3_Human0.91642191
115SA1_27219007_Chip-Seq_Bcells_Human0.91254891
116KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91200133
117FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90947000
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90321702
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.90168723
120SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88986112
121ERG_20517297_ChIP-Seq_VCAP_Human0.88905698
122NFYB_21822215_ChIP-Seq_K562_Human0.87737011
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87269838
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87245896
125GATA2_19941826_ChIP-Seq_K562_Human0.86712275
126TAF2_19829295_ChIP-Seq_ESCs_Human0.86571635
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86255234
128NANOG_20526341_ChIP-Seq_ESCs_Human0.86184776
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85503449
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85454630
131NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85186586
132ELF5_23300383_ChIP-Seq_T47D_Human0.85057628
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84788166
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84539294
135AR_20517297_ChIP-Seq_VCAP_Human0.84395205
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.83847682
137OCT4_20526341_ChIP-Seq_ESCs_Human0.83442847
138CREB1_26743006_Chip-Seq_LNCaP_Human0.82927141
139CTCF_20526341_ChIP-Seq_ESCs_Human0.82289948
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82216151
141CJUN_26792858_Chip-Seq_BT549_Human0.82180049
142RUNX1_22412390_ChIP-Seq_EML_Mouse0.81925904
143NANOG_19829295_ChIP-Seq_ESCs_Human0.81686547
144SOX2_19829295_ChIP-Seq_ESCs_Human0.81686547
145NCOR_22424771_ChIP-Seq_293T_Human0.81647794
146SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80801787
147GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79993877
148MAF_26560356_Chip-Seq_TH1_Human0.79789792
149MYB_26560356_Chip-Seq_TH1_Human0.79625798
150STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.79192725
151GATA3_21878914_ChIP-Seq_MCF-7_Human0.78649091
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.78584362
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77699837
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77262173
155P300_27268052_Chip-Seq_Bcells_Human0.77194634
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77047863
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.77047863
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76805672
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.76298651
160LXR_22292898_ChIP-Seq_THP-1_Human0.76293381
161P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76284668
162MYB_26560356_Chip-Seq_TH2_Human0.76217839
163TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75828801
164ESR2_21235772_ChIP-Seq_MCF-7_Human0.75719583
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75549851
166CDX2_22108803_ChIP-Seq_LS180_Human0.75345825
167FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75109170
168TP63_23658742_ChIP-Seq_EP156T_Human0.75065064
169GATA3_21867929_ChIP-Seq_CD8_Mouse0.75010654
170SMC4_20622854_ChIP-Seq_HELA_Human0.74965994
171CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74824554
172MAF_26560356_Chip-Seq_TH2_Human0.74012449
173FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.73870869
174POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.73822753
175NFE2_27457419_Chip-Seq_LIVER_Mouse0.73652003
176TRIM28_21343339_ChIP-Seq_HEK293_Human0.73387723
177MYC_18358816_ChIP-ChIP_MESCs_Mouse0.72761717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.37542080
2MP0001666_abnormal_nutrient_absorption6.18331453
3MP0002139_abnormal_hepatobiliary_system4.14182460
4MP0009840_abnormal_foam_cell4.13565451
5MP0003195_calcinosis3.88625607
6MP0010234_abnormal_vibrissa_follicle3.51784886
7MP0005085_abnormal_gallbladder_physiolo3.42857978
8MP0002876_abnormal_thyroid_physiology3.34992216
9MP0004264_abnormal_extraembryonic_tissu3.09336051
10MP0003252_abnormal_bile_duct2.94693833
11MP0005365_abnormal_bile_salt2.75938191
12MP0008875_abnormal_xenobiotic_pharmacok2.58334219
13MP0003183_abnormal_peptide_metabolism2.49285946
14MP0003866_abnormal_defecation2.44369950
15MP0001873_stomach_inflammation2.36530841
16MP0010329_abnormal_lipoprotein_level2.35457599
17MP0003806_abnormal_nucleotide_metabolis2.33242626
18MP0003693_abnormal_embryo_hatching2.32964674
19MP0005410_abnormal_fertilization2.28844037
20MP0003718_maternal_effect2.19876341
21MP0000462_abnormal_digestive_system2.14259868
22MP0000490_abnormal_crypts_of2.13930037
23MP0010155_abnormal_intestine_physiology1.92960158
24MP0005670_abnormal_white_adipose1.83158673
25MP0005451_abnormal_body_composition1.82609642
26MP0005084_abnormal_gallbladder_morpholo1.79609959
27MP0009697_abnormal_copulation1.62679151
28MP0001663_abnormal_digestive_system1.60354843
29MP0004019_abnormal_vitamin_homeostasis1.58648611
30MP0001664_abnormal_digestion1.53556901
31MP0000477_abnormal_intestine_morphology1.53328350
32MP0003763_abnormal_thymus_physiology1.52355743
33MP0010352_gastrointestinal_tract_polyps1.49147995
34MP0005381_digestive/alimentary_phenotyp1.46630970
35MP0002822_catalepsy1.40712323
36MP0004147_increased_porphyrin_level1.32889491
37MP0004957_abnormal_blastocyst_morpholog1.29874677
38MP0003868_abnormal_feces_composition1.29712580
39MP0003879_abnormal_hair_cell1.21621738
40MP0000609_abnormal_liver_physiology1.21116360
41MP0003705_abnormal_hypodermis_morpholog1.20368651
42MP0000537_abnormal_urethra_morphology1.19379349
43MP0003300_gastrointestinal_ulcer1.18085057
44MP0005332_abnormal_amino_acid1.16580197
45MP0003191_abnormal_cellular_cholesterol1.13220147
46MP0005448_abnormal_energy_balance1.07383781
47MP0008004_abnormal_stomach_pH1.06821171
48MP0002796_impaired_skin_barrier1.06314291
49MP0001849_ear_inflammation1.04004534
50MP0003878_abnormal_ear_physiology1.03671810
51MP0005377_hearing/vestibular/ear_phenot1.03671810
52MP0005083_abnormal_biliary_tract1.03535880
53MP0009643_abnormal_urine_homeostasis1.02382944
54MP0001764_abnormal_homeostasis1.02113947
55MP0003638_abnormal_response/metabolism_1.01272479
56MP0004947_skin_inflammation0.98053853
57MP0002118_abnormal_lipid_homeostasis0.97322232
58MP0005584_abnormal_enzyme/coenzyme_acti0.95581277
59MP0009379_abnormal_foot_pigmentation0.90111284
60MP0009333_abnormal_splenocyte_physiolog0.89558928
61MP0003186_abnormal_redox_activity0.88695429
62MP0000538_abnormal_urinary_bladder0.88161748
63MP0005058_abnormal_lysosome_morphology0.87780378
64MP0003315_abnormal_perineum_morphology0.86207504
65MP0002089_abnormal_postnatal_growth/wei0.81845863
66MP0000470_abnormal_stomach_morphology0.79652130
67MP0005266_abnormal_metabolism0.79347829
68MP0003077_abnormal_cell_cycle0.79023843
69MP0001730_embryonic_growth_arrest0.77972287
70MP0003453_abnormal_keratinocyte_physiol0.77556425
71MP0001915_intracranial_hemorrhage0.77308416
72MP0008469_abnormal_protein_level0.76659058
73MP0005501_abnormal_skin_physiology0.76054452
74MP0009384_cardiac_valve_regurgitation0.74773870
75MP0004043_abnormal_pH_regulation0.73584808
76MP0006054_spinal_hemorrhage0.73126704
77MP0005319_abnormal_enzyme/_coenzyme0.72755801
78MP0009765_abnormal_xenobiotic_induced0.72294149
79MP0005395_other_phenotype0.72251974
80MP0002254_reproductive_system_inflammat0.71703975
81MP0005023_abnormal_wound_healing0.70772780
82MP0002098_abnormal_vibrissa_morphology0.70144446
83MP0005220_abnormal_exocrine_pancreas0.69712958
84MP0000604_amyloidosis0.69590957
85MP0002277_abnormal_respiratory_mucosa0.69147063
86MP0003111_abnormal_nucleus_morphology0.68497757
87MP0002138_abnormal_hepatobiliary_system0.68413519
88MP0004272_abnormal_basement_membrane0.67431700
89MP0001845_abnormal_inflammatory_respons0.65781064
90MP0009115_abnormal_fat_cell0.65760645
91MP0002928_abnormal_bile_duct0.64995569
92MP0005408_hypopigmentation0.64650896
93MP0005187_abnormal_penis_morphology0.64392429
94MP0003698_abnormal_male_reproductive0.62329748
95MP0000598_abnormal_liver_morphology0.61629507
96MP0009053_abnormal_anal_canal0.61096390
97MP0008872_abnormal_physiological_respon0.60282082
98MP0002971_abnormal_brown_adipose0.58428913
99MP0010678_abnormal_skin_adnexa0.58319838
100MP0002405_respiratory_system_inflammati0.57944509
101MP0001216_abnormal_epidermal_layer0.57640215
102MP0000249_abnormal_blood_vessel0.54903445
103MP0010307_abnormal_tumor_latency0.54390557
104MP0003959_abnormal_lean_body0.54019559
105MP0002136_abnormal_kidney_physiology0.52801741
106MP0001929_abnormal_gametogenesis0.51985376
107MP0005310_abnormal_salivary_gland0.51252516
108MP0010094_abnormal_chromosome_stability0.50341446
109MP0009642_abnormal_blood_homeostasis0.49849129
110MP0005645_abnormal_hypothalamus_physiol0.49496757
111MP0002168_other_aberrant_phenotype0.49381193
112MP0005636_abnormal_mineral_homeostasis0.49102311
113MP0002132_abnormal_respiratory_system0.48967608
114MP0005464_abnormal_platelet_physiology0.48704631
115MP0003011_delayed_dark_adaptation0.48444461
116MP0002078_abnormal_glucose_homeostasis0.47990294
117MP0005376_homeostasis/metabolism_phenot0.47730332
118MP0000613_abnormal_salivary_gland0.47049305
119MP0002722_abnormal_immune_system0.46758264
120MP0001986_abnormal_taste_sensitivity0.46257801
121MP0003119_abnormal_digestive_system0.46185583
122MP0005164_abnormal_response_to0.46146659
123MP0000579_abnormal_nail_morphology0.45630215
124MP0003950_abnormal_plasma_membrane0.45240444
125MP0003656_abnormal_erythrocyte_physiolo0.45203138
126MP0000467_abnormal_esophagus_morphology0.44925082
127MP0002019_abnormal_tumor_incidence0.44329573
128MP0002161_abnormal_fertility/fecundity0.44120148
129MP0002086_abnormal_extraembryonic_tissu0.43716973
130MP0009785_altered_susceptibility_to0.43679710
131MP0003953_abnormal_hormone_level0.40554445
132MP0000003_abnormal_adipose_tissue0.39176632
133MP0002282_abnormal_trachea_morphology0.37792514
134MP0006036_abnormal_mitochondrial_physio0.37749606
135MP0004883_abnormal_blood_vessel0.37432398
136MP0005166_decreased_susceptibility_to0.37420241
137MP0001661_extended_life_span0.36977215
138MP0002938_white_spotting0.33663689
139MP0000678_abnormal_parathyroid_gland0.33187451
140MP0005535_abnormal_body_temperature0.32356798
141MP0003690_abnormal_glial_cell0.31594841
142MP0008874_decreased_physiological_sensi0.31573393
143MP0005551_abnormal_eye_electrophysiolog0.31379410
144MP0002970_abnormal_white_adipose0.30039742
145MP0010386_abnormal_urinary_bladder0.29645227
146MP0001756_abnormal_urination0.29565523
147MP0009763_increased_sensitivity_to0.29347330
148MP0005334_abnormal_fat_pad0.28165712
149MP0003172_abnormal_lysosome_physiology0.28122655
150MP0005167_abnormal_blood-brain_barrier0.27729633
151MP0010368_abnormal_lymphatic_system0.26001103
152MP0000566_synostosis0.25679578
153MP0006082_CNS_inflammation0.24827417
154MP0001324_abnormal_eye_pigmentation0.24596261
155MP0004233_abnormal_muscle_weight0.24100341

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.98156142
2Ileus (HP:0002595)6.92147459
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.70518584
4Hypobetalipoproteinemia (HP:0003563)6.39357165
5Acanthocytosis (HP:0001927)5.71510872
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.65347175
7Autoimmune thrombocytopenia (HP:0001973)5.49883347
8Malnutrition (HP:0004395)5.30911484
9Hyperlipoproteinemia (HP:0010980)5.26831871
10Joint hemorrhage (HP:0005261)5.14103896
11Complement deficiency (HP:0004431)5.11854541
12Hypoalphalipoproteinemia (HP:0003233)4.89090597
13Autoimmune hemolytic anemia (HP:0001890)4.43659280
14Right ventricular cardiomyopathy (HP:0011663)4.41925178
15Conjugated hyperbilirubinemia (HP:0002908)4.37482037
16Fat malabsorption (HP:0002630)4.33004035
17Systemic lupus erythematosus (HP:0002725)4.23199902
18Abnormality of the common coagulation pathway (HP:0010990)4.19017028
19Severe combined immunodeficiency (HP:0004430)4.15424433
20Combined immunodeficiency (HP:0005387)4.13511648
21Glomerulonephritis (HP:0000099)4.13229933
22Abnormality of complement system (HP:0005339)4.11120462
23Spontaneous abortion (HP:0005268)3.88224444
24Increased IgE level (HP:0003212)3.84363557
25Hydroxyprolinuria (HP:0003080)3.77218452
26Abnormality of proline metabolism (HP:0010907)3.77218452
27Hypolipoproteinemia (HP:0010981)3.73956008
28Chronic diarrhea (HP:0002028)3.71703383
29Generalized aminoaciduria (HP:0002909)3.55907581
30Poikilocytosis (HP:0004447)3.51080078
31Hyperglycinuria (HP:0003108)3.40375461
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.31491449
33Pigmentary retinal degeneration (HP:0001146)3.27329518
34B lymphocytopenia (HP:0010976)3.25163748
35Abnormality of B cell number (HP:0010975)3.25163748
36Osteomalacia (HP:0002749)3.23725288
37Mesangial abnormality (HP:0001966)3.21211211
38Intrahepatic cholestasis (HP:0001406)3.20916835
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.17253107
40Nephritis (HP:0000123)3.13469004
41Gingival bleeding (HP:0000225)3.07568619
42Abnormality of sulfur amino acid metabolism (HP:0004339)3.07240863
43Cupped ribs (HP:0000887)3.07007371
44Glycosuria (HP:0003076)3.05807962
45Abnormality of urine glucose concentration (HP:0011016)3.05807962
46Abnormality of the vitamin B12 metabolism (HP:0004341)3.03363489
47Widely patent fontanelles and sutures (HP:0004492)2.97565870
48Pustule (HP:0200039)2.97347678
49Villous atrophy (HP:0011473)2.92079756
50Abnormality of small intestinal villus morphology (HP:0011472)2.92079756
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.90625979
52Chronic hepatic failure (HP:0100626)2.88588221
53Rickets (HP:0002748)2.79516349
54Abnormality of vitamin B metabolism (HP:0004340)2.79453840
55Delayed CNS myelination (HP:0002188)2.77719973
56Hemorrhage of the eye (HP:0011885)2.75495877
57Menorrhagia (HP:0000132)2.73829188
58Abnormal biliary tract morphology (HP:0012440)2.70326478
59Hypercholesterolemia (HP:0003124)2.68982973
60Dehydration (HP:0001944)2.68357398
61Increased mean platelet volume (HP:0011877)2.66896927
62Abnormality of vitamin metabolism (HP:0100508)2.66736055
63Xanthomatosis (HP:0000991)2.66143192
64Sensorimotor neuropathy (HP:0007141)2.65184283
65Hyperglycinemia (HP:0002154)2.65060283
66Potter facies (HP:0002009)2.64376742
67Facial shape deformation (HP:0011334)2.64376742
68Gastrointestinal dysmotility (HP:0002579)2.60373450
69Abnormality of methionine metabolism (HP:0010901)2.52957334
70Abdominal distention (HP:0003270)2.52711415
71Abnormal platelet volume (HP:0011876)2.52059815
72Thyroiditis (HP:0100646)2.52057293
73Asymmetric septal hypertrophy (HP:0001670)2.52033600
74Abnormality of carpal bone ossification (HP:0006257)2.50281014
75Recurrent gram-negative bacterial infections (HP:0005420)2.46772618
76Abnormal gallbladder physiology (HP:0012438)2.46109638
77Cholecystitis (HP:0001082)2.46109638
78Abnormality of glycine metabolism (HP:0010895)2.45199568
79Abnormality of serine family amino acid metabolism (HP:0010894)2.45199568
80Bile duct proliferation (HP:0001408)2.44377634
81Abnormal biliary tract physiology (HP:0012439)2.44377634
82Male infertility (HP:0003251)2.42084231
83Elevated alkaline phosphatase (HP:0003155)2.38521963
84Hyperammonemia (HP:0001987)2.32589472
85Megaloblastic anemia (HP:0001889)2.31368276
86Abnormality of alkaline phosphatase activity (HP:0004379)2.29865894
87Abnormal enzyme/coenzyme activity (HP:0012379)2.27419477
88Abnormality of eosinophils (HP:0001879)2.27378173
89Proximal tubulopathy (HP:0000114)2.25190111
90Granulocytopenia (HP:0001913)2.23818733
91Abnormal pupillary function (HP:0007686)2.23812577
92Vascular calcification (HP:0004934)2.22658168
93Metabolic acidosis (HP:0001942)2.22486813
94Abnormality of purine metabolism (HP:0004352)2.22193779
95Biliary tract neoplasm (HP:0100574)2.18398278
96Hyperphosphaturia (HP:0003109)2.18204786
97Woolly hair (HP:0002224)2.17068636
98Abnormality of nucleobase metabolism (HP:0010932)2.16699057
99Abnormality of serum amino acid levels (HP:0003112)2.15586849
100Reticulocytosis (HP:0001923)2.14663461
101Nausea (HP:0002018)2.12314448
102Cheilitis (HP:0100825)2.11860432
103Abnormality of the gastric mucosa (HP:0004295)2.10056167
104Eosinophilia (HP:0001880)2.09801076
105Wide cranial sutures (HP:0010537)2.08304047
106Amyloidosis (HP:0011034)2.06293739
107Abnormality of pyrimidine metabolism (HP:0004353)2.05709613
108Pulmonary embolism (HP:0002204)2.04035990
109Nephrolithiasis (HP:0000787)2.02577656
110Thrombophlebitis (HP:0004418)2.00571636
111Deep venous thrombosis (HP:0002625)10.2174994
112Abnormal glucose tolerance (HP:0001952)1.99920502
113Cardiovascular calcification (HP:0011915)1.98060991
114Breast hypoplasia (HP:0003187)1.95917507
115Goiter (HP:0000853)1.95203575
116Purpura (HP:0000979)1.95087592
117Spastic paraparesis (HP:0002313)1.94816843
118Micronodular cirrhosis (HP:0001413)1.94604966
119Retinal atrophy (HP:0001105)1.92576316
120Abnormal hand bone ossification (HP:0010660)1.89298017
121Abnormality of the intrinsic pathway (HP:0010989)1.88564264
122Pancreatitis (HP:0001733)1.88350101
123Cholelithiasis (HP:0001081)1.88324798
124Polycythemia (HP:0001901)1.86837218
125Palpitations (HP:0001962)1.86380933
126Rectal prolapse (HP:0002035)1.85721827
127Epidermoid cyst (HP:0200040)1.84556257
128Abnormal gallbladder morphology (HP:0012437)1.84344068
129Hyperbilirubinemia (HP:0002904)1.83779273
130Abnormality of fatty-acid metabolism (HP:0004359)1.83671164
131Hyperuricemia (HP:0002149)1.83293206
132Increased purine levels (HP:0004368)1.83293206
133Abnormal ossification of hand bones (HP:0005921)1.81743969
134Microretrognathia (HP:0000308)1.79640300
135Hypophosphatemic rickets (HP:0004912)1.79220040
136Steatorrhea (HP:0002570)1.77355408
137Milia (HP:0001056)1.76640725
138Vacuolated lymphocytes (HP:0001922)1.75269232
139Syncope (HP:0001279)1.75051713
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75003031
141Confusion (HP:0001289)1.73890542
142Congenital sensorineural hearing impairment (HP:0008527)1.72818502
143Abnormal urine phosphate concentration (HP:0012599)1.72600668
144Reduced antithrombin III activity (HP:0001976)1.71556273
145Mitral stenosis (HP:0001718)1.71075508
146Tubulointerstitial nephritis (HP:0001970)1.70400100
147Focal segmental glomerulosclerosis (HP:0000097)1.70185270
148Irritability (HP:0000737)1.69693921
149Abnormality of the 1st metacarpal (HP:0010009)1.68582501
150Late onset (HP:0003584)1.68168491
151Abnormality of reticulocytes (HP:0004312)1.67310162
152Abnormality of the fingertips (HP:0001211)1.66578824
153Recurrent viral infections (HP:0004429)1.65139456
154Esophageal varix (HP:0002040)1.64546920
155Flat acetabular roof (HP:0003180)1.59078315
156Neoplasm of the rectum (HP:0100743)1.57018655
157Exocrine pancreatic insufficiency (HP:0001738)1.56611296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG8.56518160
2MST44.37333166
3FRK3.91109264
4MUSK3.42791546
5INSRR3.26945223
6LMTK23.23027900
7MST1R3.21583050
8GRK63.13733587
9NME12.97769108
10EPHA22.89316192
11BRD42.66340976
12STK102.65017797
13MAP3K122.59960877
14PRKG22.55699572
15MAP3K102.42603331
16TTK2.33287388
17TESK22.26957479
18PNCK2.25263337
19PDK22.10820829
20EEF2K2.02645301
21PDPK12.01712741
22ERN11.99771951
23MAP4K11.93688859
24MAPKAPK31.83080805
25PLK21.82516600
26PDK11.77865009
27NUAK11.77830125
28MAP2K21.76498929
29LATS11.65696739
30RPS6KB21.65335784
31STK38L1.63474411
32ERBB41.58120200
33MAP3K81.57349905
34TAOK11.51530205
35TAOK31.45135636
36PTK61.45072622
37RIPK11.42352490
38STK381.38389800
39AKT31.35959961
40MAP3K111.25625560
41FGFR31.19056325
42MAP2K61.17620743
43BRAF1.16945827
44PLK41.09721335
45BCKDK1.09549714
46STK241.09094967
47MAP3K131.07238983
48CAMK1G1.06169103
49PKN21.06167031
50FGFR41.06137719
51ZAP701.05514776
52MAP3K61.05129565
53AURKB1.04553154
54PRKCI1.02416481
55MET1.02320215
56NEK61.01702766
57EIF2AK11.00869871
58MAPK150.98846532
59TESK10.97775244
60STK30.96139656
61TYK20.95146344
62DDR20.91437063
63NEK20.88788708
64MAP2K30.88010794
65NLK0.86254639
66CASK0.86227113
67CDK120.85751109
68MAP3K70.84786335
69BUB10.84759806
70LRRK20.84078381
71KSR20.83163182
72PBK0.83134969
73ACVR1B0.82722389
74PRKACG0.82611593
75PRKCG0.80965396
76MELK0.80460908
77TXK0.79561093
78JAK30.78914085
79TBK10.77588406
80MAPK110.75870140
81NME20.74344291
82PRKAA20.71861846
83TIE10.69246304
84PRKCZ0.68947886
85CDC70.66746303
86PLK10.66444055
87EIF2AK30.65881717
88MAP3K30.65339536
89IKBKE0.64917297
90KDR0.64706184
91CDK70.62175910
92PAK40.60039578
93ITK0.58756784
94CDK90.55887861
95SGK4940.53525197
96SGK2230.53525197
97STK40.52519360
98PTK20.52269678
99MAP3K20.51007708
100DYRK1B0.50208926
101PRKG10.49803054
102EPHB20.49716860
103ABL20.49543414
104PIM10.49024099
105WNK40.47442611
106SGK10.46733052
107CHUK0.45644959
108CHEK20.45182161
109CDK40.43722511
110CSNK1D0.43573707
111RAF10.42571099
112PDGFRA0.42324570
113PRKCQ0.41787127
114NEK90.37726588
115NEK10.37516208
116LATS20.36287083
117MAP3K10.36066059
118PTK2B0.36014449
119ARAF0.34171288
120FGFR10.34017609
121PRKACB0.33523951
122ICK0.33451870
123PRKACA0.33426506
124PRKAA10.32699019
125IRAK30.32694313
126PRKCA0.32692457
127CSK0.32370117
128ERBB20.31761404
129TGFBR20.31589432
130MAP3K90.31354637
131PIM20.30956241
132SGK20.30483503
133RPS6KA40.30476567
134LCK0.30078292
135SGK30.29460234
136MAPKAPK20.28700294
137WEE10.28398361
138IGF1R0.28066539
139PAK10.26302893
140BMX0.26176738
141TYRO30.26036920
142FGFR20.25900739
143WNK10.25875439
144PIK3CA0.25803796
145MYLK0.24711202
146RPS6KA10.24174745
147GRK10.23640300
148PRKCB0.23046258
149MAP2K10.22798047
150JAK10.20070994
151CSNK1A10.18948701
152SRC0.16746533
153RPS6KA30.16100444
154TAOK20.14368868
155CSNK2A20.14343784
156NTRK30.14149354

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.42952202
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.46052794
3Vitamin digestion and absorption_Homo sapiens_hsa049773.92196998
4Renin-angiotensin system_Homo sapiens_hsa046143.75265271
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44053989
6Complement and coagulation cascades_Homo sapiens_hsa046103.43885766
7Mineral absorption_Homo sapiens_hsa049783.02922854
8Folate biosynthesis_Homo sapiens_hsa007903.00173698
9Galactose metabolism_Homo sapiens_hsa000522.66579231
10Phenylalanine metabolism_Homo sapiens_hsa003602.66347655
11Caffeine metabolism_Homo sapiens_hsa002322.34631845
12Starch and sucrose metabolism_Homo sapiens_hsa005002.30923515
13Protein digestion and absorption_Homo sapiens_hsa049742.20086738
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17555325
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.16061470
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.08444917
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05040575
18Fructose and mannose metabolism_Homo sapiens_hsa000511.87212557
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66919097
20Butanoate metabolism_Homo sapiens_hsa006501.65819255
21Bile secretion_Homo sapiens_hsa049761.64672595
22Glutathione metabolism_Homo sapiens_hsa004801.58799961
23Histidine metabolism_Homo sapiens_hsa003401.58239458
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56416851
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53332785
26Glycerolipid metabolism_Homo sapiens_hsa005611.50897981
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49899260
28Arginine biosynthesis_Homo sapiens_hsa002201.45320217
29Sulfur metabolism_Homo sapiens_hsa009201.36302614
30Tyrosine metabolism_Homo sapiens_hsa003501.36095127
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35107323
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30826087
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27559490
34Tryptophan metabolism_Homo sapiens_hsa003801.26749960
35Linoleic acid metabolism_Homo sapiens_hsa005911.20624974
36Fatty acid degradation_Homo sapiens_hsa000711.17637615
37PPAR signaling pathway_Homo sapiens_hsa033201.17000506
38Arginine and proline metabolism_Homo sapiens_hsa003301.16534576
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14791049
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12418920
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.08222817
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08112228
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07889390
44Fatty acid biosynthesis_Homo sapiens_hsa000611.02179615
45Pentose phosphate pathway_Homo sapiens_hsa000300.97729748
46Biosynthesis of amino acids_Homo sapiens_hsa012300.97487230
47Pancreatic secretion_Homo sapiens_hsa049720.97255668
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96828369
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93022736
50Pyruvate metabolism_Homo sapiens_hsa006200.92875928
51Sulfur relay system_Homo sapiens_hsa041220.90279519
52Carbon metabolism_Homo sapiens_hsa012000.88688385
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84980394
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84502580
55Staphylococcus aureus infection_Homo sapiens_hsa051500.83812873
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83693859
57Selenocompound metabolism_Homo sapiens_hsa004500.83610843
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.80174291
59Primary immunodeficiency_Homo sapiens_hsa053400.79376837
60ABC transporters_Homo sapiens_hsa020100.79217404
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79121664
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76598151
63Arachidonic acid metabolism_Homo sapiens_hsa005900.75422131
64Chemical carcinogenesis_Homo sapiens_hsa052040.75010319
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.74255329
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72584708
67beta-Alanine metabolism_Homo sapiens_hsa004100.72396612
68Nitrogen metabolism_Homo sapiens_hsa009100.70713823
69Sphingolipid metabolism_Homo sapiens_hsa006000.65899989
70Fatty acid elongation_Homo sapiens_hsa000620.64753393
71Vitamin B6 metabolism_Homo sapiens_hsa007500.63727755
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61822127
73Retinol metabolism_Homo sapiens_hsa008300.58770481
74Thyroid cancer_Homo sapiens_hsa052160.52727226
75One carbon pool by folate_Homo sapiens_hsa006700.52268148
76DNA replication_Homo sapiens_hsa030300.47892039
77Peroxisome_Homo sapiens_hsa041460.45455588
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44873663
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.44723267
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.44708025
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.44642136
82Lysine degradation_Homo sapiens_hsa003100.43579656
83Ether lipid metabolism_Homo sapiens_hsa005650.43281306
84Pyrimidine metabolism_Homo sapiens_hsa002400.41087500
85Metabolic pathways_Homo sapiens_hsa011000.38950370
86Purine metabolism_Homo sapiens_hsa002300.35059929
87p53 signaling pathway_Homo sapiens_hsa041150.34623202
88Thyroid hormone synthesis_Homo sapiens_hsa049180.33292292
89Mismatch repair_Homo sapiens_hsa034300.33155932
90Tight junction_Homo sapiens_hsa045300.33067705
91Ribosome_Homo sapiens_hsa030100.30441336
92Prion diseases_Homo sapiens_hsa050200.29088094
93Hepatitis C_Homo sapiens_hsa051600.27397236
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27322132
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.26728025
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25845643
97Cell cycle_Homo sapiens_hsa041100.25088840
98RNA degradation_Homo sapiens_hsa030180.25008515
99Propanoate metabolism_Homo sapiens_hsa006400.22372622
100Adherens junction_Homo sapiens_hsa045200.19717980
101Influenza A_Homo sapiens_hsa051640.18766427
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17927650
103Steroid biosynthesis_Homo sapiens_hsa001000.17448544
104Fatty acid metabolism_Homo sapiens_hsa012120.17397704
105Bladder cancer_Homo sapiens_hsa052190.17043452
106Hematopoietic cell lineage_Homo sapiens_hsa046400.15149860
107Insulin resistance_Homo sapiens_hsa049310.14212330
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.14138391
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12957315
110African trypanosomiasis_Homo sapiens_hsa051430.12384191
111Apoptosis_Homo sapiens_hsa042100.10941800
112Base excision repair_Homo sapiens_hsa034100.10142716
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.09927046
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09908823
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.09407249
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09173245
117T cell receptor signaling pathway_Homo sapiens_hsa046600.09168842
118Herpes simplex infection_Homo sapiens_hsa051680.08706879
119VEGF signaling pathway_Homo sapiens_hsa043700.06921513
120Other glycan degradation_Homo sapiens_hsa005110.06537684
121Pertussis_Homo sapiens_hsa051330.03180546
122Glucagon signaling pathway_Homo sapiens_hsa049220.01671989
123Amoebiasis_Homo sapiens_hsa05146-0.2154128
124Inositol phosphate metabolism_Homo sapiens_hsa00562-0.2022499
125AMPK signaling pathway_Homo sapiens_hsa04152-0.1801741
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1366032
127Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1343641
128ECM-receptor interaction_Homo sapiens_hsa04512-0.1315621
129Type II diabetes mellitus_Homo sapiens_hsa04930-0.0536619
130N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0498719
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0119100
132Serotonergic synapse_Homo sapiens_hsa04726-0.0074680

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