IGSF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.69708814
2desmosome organization (GO:0002934)5.25750488
3limb bud formation (GO:0060174)4.83732129
4neuron cell-cell adhesion (GO:0007158)4.57561515
5sympathetic nervous system development (GO:0048485)4.42540120
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.26950296
7negative regulation of axon extension involved in axon guidance (GO:0048843)4.12086928
8cell migration in hindbrain (GO:0021535)4.07892672
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06231358
10axonal fasciculation (GO:0007413)4.03074093
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.95295271
12dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.88670420
13neuron recognition (GO:0008038)3.87864439
14regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.82044087
15ear development (GO:0043583)3.81510404
16negative regulation of axon guidance (GO:1902668)3.81336137
17apical protein localization (GO:0045176)3.77347804
18cranial nerve morphogenesis (GO:0021602)3.74376638
19presynaptic membrane assembly (GO:0097105)3.69418208
20negative regulation of keratinocyte proliferation (GO:0010839)3.58909244
21positive regulation of synapse assembly (GO:0051965)3.58713082
22central nervous system projection neuron axonogenesis (GO:0021952)3.58263500
23semaphorin-plexin signaling pathway (GO:0071526)3.56686932
24regulation of water loss via skin (GO:0033561)3.55649526
25cerebral cortex radially oriented cell migration (GO:0021799)3.53496310
26pyrimidine nucleobase catabolic process (GO:0006208)3.50273169
27establishment of tissue polarity (GO:0007164)3.41566376
28establishment of planar polarity (GO:0001736)3.41566376
29facial nerve structural organization (GO:0021612)3.41170530
30postsynaptic membrane organization (GO:0001941)3.39649677
31regulation of axon extension involved in axon guidance (GO:0048841)3.38618589
32gonadal mesoderm development (GO:0007506)3.31742481
33paraxial mesoderm development (GO:0048339)3.27487040
34regulation of axon guidance (GO:1902667)3.27364352
35regulation of cardioblast differentiation (GO:0051890)3.26326807
36asymmetric protein localization (GO:0008105)3.24956600
37polarized epithelial cell differentiation (GO:0030859)3.23570960
38retinal ganglion cell axon guidance (GO:0031290)3.23061383
39establishment of skin barrier (GO:0061436)3.22647211
40gap junction assembly (GO:0016264)3.20525921
41presynaptic membrane organization (GO:0097090)3.18616497
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.16429833
43epithelial cell-cell adhesion (GO:0090136)3.12655980
44layer formation in cerebral cortex (GO:0021819)3.11627226
45lateral sprouting from an epithelium (GO:0060601)3.11492542
46dendritic spine morphogenesis (GO:0060997)3.07249042
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.05629613
48regulation of establishment of planar polarity (GO:0090175)3.01966794
49intestinal epithelial cell development (GO:0060576)2.99707007
50regulation of synapse assembly (GO:0051963)2.98446843
51melanin biosynthetic process (GO:0042438)2.96523538
52cranial nerve structural organization (GO:0021604)2.92977755
53central nervous system neuron axonogenesis (GO:0021955)2.92411579
54negative regulation of axon extension (GO:0030517)2.92264324
55generation of neurons (GO:0048699)2.90347777
56epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90064398
57vocalization behavior (GO:0071625)2.86984253
58spinal cord development (GO:0021510)2.86923990
59neuron projection extension involved in neuron projection guidance (GO:1902284)2.83489125
60axon extension involved in axon guidance (GO:0048846)2.83489125
61convergent extension (GO:0060026)2.82680940
62axon extension (GO:0048675)2.82642953
63ectodermal placode formation (GO:0060788)2.81212588
64regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81100470
65microtubule depolymerization (GO:0007019)2.78420264
66negative regulation of cell fate specification (GO:0009996)2.77862203
67establishment of monopolar cell polarity (GO:0061162)2.77685381
68establishment or maintenance of monopolar cell polarity (GO:0061339)2.77685381
69embryonic retina morphogenesis in camera-type eye (GO:0060059)2.77080772
70branching involved in salivary gland morphogenesis (GO:0060445)2.75552610
71dendrite development (GO:0016358)2.74429676
72establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.73588745
73establishment of apical/basal cell polarity (GO:0035089)2.73378020
74cell-substrate junction assembly (GO:0007044)2.72831143
75cell surface receptor signaling pathway involved in heart development (GO:0061311)2.72608436
76neurofilament cytoskeleton organization (GO:0060052)2.72432168
77negative regulation of microtubule polymerization (GO:0031115)2.72071715
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71312203
79melanin metabolic process (GO:0006582)2.70214185
80hippocampus development (GO:0021766)2.69509880
81metanephric mesenchyme development (GO:0072075)2.67697706
82cardiac right ventricle morphogenesis (GO:0003215)2.67018584
83neuronal action potential (GO:0019228)2.66064274
84short-term memory (GO:0007614)2.64027804
85regulation of pigment cell differentiation (GO:0050932)2.63935766
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.62346238
87Golgi transport vesicle coating (GO:0048200)2.62228985
88COPI coating of Golgi vesicle (GO:0048205)2.62228985
89kidney morphogenesis (GO:0060993)2.61280790
90neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.60922887
91negative regulation of chondrocyte differentiation (GO:0032331)2.59745830
92non-canonical Wnt signaling pathway (GO:0035567)2.58073182
93negative regulation of cell fate commitment (GO:0010454)2.56656192
94endocardial cushion morphogenesis (GO:0003203)2.56303634
95atrial cardiac muscle cell action potential (GO:0086014)2.55780617
96enteric nervous system development (GO:0048484)2.55567923
97surfactant homeostasis (GO:0043129)2.54988771
98nucleobase catabolic process (GO:0046113)2.54846251
99kidney mesenchyme development (GO:0072074)2.54723157
100regulation of NFAT protein import into nucleus (GO:0051532)2.54707770
101cornea development in camera-type eye (GO:0061303)2.53664271
102ectoderm development (GO:0007398)2.53302996
103dendrite morphogenesis (GO:0048813)2.52460816
104head development (GO:0060322)2.50432517
105mating behavior (GO:0007617)2.50250716
106positive regulation of protein depolymerization (GO:1901881)2.49895673
107embryonic camera-type eye morphogenesis (GO:0048596)2.49762302
108mesenchyme morphogenesis (GO:0072132)2.47209480
109embryonic eye morphogenesis (GO:0048048)2.46601512
110establishment or maintenance of apical/basal cell polarity (GO:0035088)2.46190238
111establishment or maintenance of bipolar cell polarity (GO:0061245)2.46190238
112eyelid development in camera-type eye (GO:0061029)2.46085219
113G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.45723194
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45678382
115negative chemotaxis (GO:0050919)2.45390778
116regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.44772736
117eye morphogenesis (GO:0048592)2.44765137
118body morphogenesis (GO:0010171)2.44562625
119regulation of keratinocyte proliferation (GO:0010837)2.44371003
120adherens junction organization (GO:0034332)2.43964486
121ganglion development (GO:0061548)2.43440172
122ephrin receptor signaling pathway (GO:0048013)2.42817728
123forebrain neuron development (GO:0021884)2.42771460
124branching involved in mammary gland duct morphogenesis (GO:0060444)2.42258329
125regulation of collateral sprouting (GO:0048670)2.41891764
126regulation of synapse organization (GO:0050807)2.41085489
127establishment of mitochondrion localization (GO:0051654)2.40358222
128glomerulus development (GO:0032835)2.40118500
129multicellular organismal water homeostasis (GO:0050891)2.39065533
130cell proliferation in forebrain (GO:0021846)2.38801222
131maternal placenta development (GO:0001893)2.38719381
132cardiac ventricle formation (GO:0003211)2.38383458
133protein neddylation (GO:0045116)2.37787249
134cardiac chamber formation (GO:0003207)2.37352243
135adherens junction assembly (GO:0034333)2.37212893
136retina layer formation (GO:0010842)2.36270567
137protein retention in ER lumen (GO:0006621)2.36041167
138cerebral cortex cell migration (GO:0021795)2.35830374
139notochord development (GO:0030903)2.35732038
140regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.34820321
141regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.34683783
142embryonic body morphogenesis (GO:0010172)2.34571838
143mesenchymal to epithelial transition (GO:0060231)2.34083342
144morphogenesis of an epithelial sheet (GO:0002011)2.34062794
145negative regulation of catenin import into nucleus (GO:0035414)2.33515536
146anatomical structure arrangement (GO:0048532)2.33353262
147camera-type eye morphogenesis (GO:0048593)2.32849343
148cell communication involved in cardiac conduction (GO:0086065)2.32139700
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32064024
150chemical homeostasis within a tissue (GO:0048875)2.31680103
151heart valve morphogenesis (GO:0003179)2.30856099
152bone trabecula formation (GO:0060346)2.28826404
153embryonic digestive tract morphogenesis (GO:0048557)2.28781543
154neuron projection extension (GO:1990138)2.28591409
155embryonic forelimb morphogenesis (GO:0035115)2.28186626
156positive regulation of keratinocyte differentiation (GO:0045618)2.28073127
157prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.27669551
158negative regulation of striated muscle cell apoptotic process (GO:0010664)2.27593909
159microtubule polymerization or depolymerization (GO:0031109)2.27094509
160negative regulation of axonogenesis (GO:0050771)2.26785597
161axonogenesis (GO:0007409)2.26437342
162positive regulation of actin filament depolymerization (GO:0030836)2.26078445
163cell differentiation involved in kidney development (GO:0061005)2.26033736
164regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.24614900
165insulin-like growth factor receptor signaling pathway (GO:0048009)2.24232732
166inner ear receptor stereocilium organization (GO:0060122)2.24171261
167transmission of nerve impulse (GO:0019226)2.23592513
168regulation of catenin import into nucleus (GO:0035412)2.23345920
169secondary metabolite biosynthetic process (GO:0044550)2.23293310
170peripheral nervous system neuron development (GO:0048935)2.23006609
171negative regulation of dendrite morphogenesis (GO:0050774)2.22886018
172regulation of fatty acid beta-oxidation (GO:0031998)2.22606362
173keratinocyte development (GO:0003334)2.22515170
174female gonad development (GO:0008585)2.22185436
175protein localization to synapse (GO:0035418)2.21978160
176olfactory bulb development (GO:0021772)2.20417581
177chaperone-mediated protein transport (GO:0072321)2.20192342
178regulation of respiratory system process (GO:0044065)2.19231292
179intraciliary transport (GO:0042073)2.19054275
180positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.18807728
181cranial nerve development (GO:0021545)2.18126761
182regulation of extent of cell growth (GO:0061387)2.18002039
183negative regulation of dendrite development (GO:2000171)2.17328425
184histone H2B ubiquitination (GO:0033523)2.16313360
185neural crest cell development (GO:0014032)2.16042848
186forelimb morphogenesis (GO:0035136)2.15392401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.41826457
2EZH2_22144423_ChIP-Seq_EOC_Human5.66523064
3GBX2_23144817_ChIP-Seq_PC3_Human3.14071815
4ESR1_15608294_ChIP-ChIP_MCF-7_Human2.96792786
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.89742399
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82287051
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.75075021
8ZNF263_19887448_ChIP-Seq_K562_Human2.59564023
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56683028
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.52049927
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.50191881
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.42677830
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41803439
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40804620
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40546720
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40546720
17* ESR1_20079471_ChIP-ChIP_T-47D_Human2.37828075
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35175294
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.33518424
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28859417
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26259918
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26045296
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24355283
24TAF15_26573619_Chip-Seq_HEK293_Human2.20061708
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14380983
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.11581539
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11344410
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10448039
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10236963
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07249183
31POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06330114
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05957033
33RNF2_27304074_Chip-Seq_NSC_Mouse2.05219779
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.04979331
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04129864
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02673787
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02588495
38* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01614737
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.98611552
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97774531
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.91804176
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90739054
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90359215
44AR_21572438_ChIP-Seq_LNCaP_Human1.85454646
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85337846
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81859974
47FUS_26573619_Chip-Seq_HEK293_Human1.79457912
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78170022
49P300_19829295_ChIP-Seq_ESCs_Human1.72740503
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72019491
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71607539
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69155536
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67350923
54* RUNX1_27514584_Chip-Seq_MCF-7_Human1.65600677
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.65312209
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.63723444
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61537696
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59361416
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57108822
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56633965
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.54644618
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53815931
63VDR_22108803_ChIP-Seq_LS180_Human1.52886763
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52609501
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.51150882
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50732895
67KDM2B_26808549_Chip-Seq_K562_Human1.49534169
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48473447
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45518521
70CLOCK_20551151_ChIP-Seq_293T_Human1.43929312
71ZNF274_21170338_ChIP-Seq_K562_Hela1.43493828
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43241063
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43241063
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41997333
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40793927
76SMAD4_21799915_ChIP-Seq_A2780_Human1.40231417
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39616345
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39260366
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.38163197
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38155536
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38038468
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.37371109
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36606057
84EWS_26573619_Chip-Seq_HEK293_Human1.36257443
85REST_21632747_ChIP-Seq_MESCs_Mouse1.35192887
86IGF1R_20145208_ChIP-Seq_DFB_Human1.33878612
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.33034484
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28245782
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.27154993
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27130983
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.27060489
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27042727
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.25390990
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24194389
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21365173
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.20846096
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20200488
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.19602452
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19023532
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18671817
101ER_23166858_ChIP-Seq_MCF-7_Human1.18060882
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17974251
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17822516
104* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15858795
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14905142
106RUNX2_22187159_ChIP-Seq_PCA_Human1.14889231
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.14889056
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13509278
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13149555
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11209519
111TP53_18474530_ChIP-ChIP_U2OS_Human1.11014688
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08989243
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07587684
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06606529
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06567773
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06538835
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06529871
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.06140011
119AR_25329375_ChIP-Seq_VCAP_Human1.05101259
120AR_21909140_ChIP-Seq_LNCAP_Human1.04410780
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03719423
122SOX2_16153702_ChIP-ChIP_HESCs_Human1.03053843
123* SOX9_26525672_Chip-Seq_HEART_Mouse1.02679888
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02588028
125E2F7_22180533_ChIP-Seq_HELA_Human1.02501019
126STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01926988
127* AHR_22903824_ChIP-Seq_MCF-7_Human1.01868494
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01707928
129PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00963658
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00048213
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00030118
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99325942
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99170087
134STAT3_23295773_ChIP-Seq_U87_Human0.99070155
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98629179
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98556336
137* ARNT_22903824_ChIP-Seq_MCF-7_Human0.98257856
138JUN_21703547_ChIP-Seq_K562_Human0.98078221
139* ISL1_27105846_Chip-Seq_CPCs_Mouse0.97947234
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.97327511
141* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96972495
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95868726
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95868726
144* KLF5_25053715_ChIP-Seq_YYC3_Human0.95635291
145CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95568741
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95435653
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95207479
148* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95027061
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95010017
150* REST_18959480_ChIP-ChIP_MESCs_Mouse0.94951921
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.94869152
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94829543
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.94753297
154RARB_27405468_Chip-Seq_BRAIN_Mouse0.93681440
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91636310
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91467953
157TET1_21490601_ChIP-Seq_MESCs_Mouse0.91455269
158* GATA3_24758297_ChIP-Seq_MCF-7_Human0.91319234
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91303561
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90860334
161FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90468129
162NANOG_21062744_ChIP-ChIP_HESCs_Human0.90366310
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90365469
164* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87929807
165* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83240188
166* CREB1_26743006_Chip-Seq_LNCaP_Human0.83158492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.09347822
2MP0003880_abnormal_central_pattern2.80610558
3MP0000778_abnormal_nervous_system2.53016085
4MP0000566_synostosis2.52311219
5MP0006276_abnormal_autonomic_nervous2.51570702
6MP0002796_impaired_skin_barrier2.49971262
7MP0003705_abnormal_hypodermis_morpholog2.48097669
8MP0004270_analgesia2.39033186
9MP0003941_abnormal_skin_development2.32575849
10MP0004264_abnormal_extraembryonic_tissu2.32230515
11MP0009379_abnormal_foot_pigmentation2.30065155
12MP0005257_abnormal_intraocular_pressure2.22011716
13MP0003385_abnormal_body_wall2.20560934
14MP0004381_abnormal_hair_follicle2.18830913
15MP0002938_white_spotting2.17676927
16MP0008789_abnormal_olfactory_epithelium2.17215571
17MP0003122_maternal_imprinting2.11991313
18MP0001188_hyperpigmentation2.11959375
19MP0002102_abnormal_ear_morphology2.10427256
20MP0002184_abnormal_innervation2.06872508
21MP0002098_abnormal_vibrissa_morphology2.03341012
22MP0002751_abnormal_autonomic_nervous1.98000632
23MP0005423_abnormal_somatic_nervous1.97652146
24MP0010678_abnormal_skin_adnexa1.96389417
25MP0002735_abnormal_chemical_nociception1.92782586
26MP0009250_abnormal_appendicular_skeleto1.92057136
27MP0000383_abnormal_hair_follicle1.89439009
28MP0010030_abnormal_orbit_morphology1.87583640
29MP0006292_abnormal_olfactory_placode1.86872900
30MP0002734_abnormal_mechanical_nocicepti1.84535822
31MP0000049_abnormal_middle_ear1.82630576
32MP0001968_abnormal_touch/_nociception1.79683538
33MP0001849_ear_inflammation1.79446218
34MP0003136_yellow_coat_color1.74774891
35MP0003938_abnormal_ear_development1.68329914
36MP0003937_abnormal_limbs/digits/tail_de1.67348219
37MP0005501_abnormal_skin_physiology1.63052064
38MP0005499_abnormal_olfactory_system1.61874077
39MP0005394_taste/olfaction_phenotype1.61874077
40MP0005171_absent_coat_pigmentation1.61240215
41MP0005409_darkened_coat_color1.60157538
42MP0000537_abnormal_urethra_morphology1.56331684
43MP0000467_abnormal_esophagus_morphology1.56296111
44MP0000377_abnormal_hair_follicle1.54052185
45MP0005275_abnormal_skin_tensile1.53804474
46MP0003121_genomic_imprinting1.52464269
47MP0002697_abnormal_eye_size1.51848720
48MP0002822_catalepsy1.51169392
49MP0002249_abnormal_larynx_morphology1.49338898
50MP0002877_abnormal_melanocyte_morpholog1.48626842
51MP0001984_abnormal_olfaction1.47836045
52MP0003755_abnormal_palate_morphology1.46568039
53MP0003942_abnormal_urinary_system1.45658846
54MP0005503_abnormal_tendon_morphology1.45119320
55MP0003635_abnormal_synaptic_transmissio1.41277657
56MP0003315_abnormal_perineum_morphology1.38797642
57MP0000372_irregular_coat_pigmentation1.37724248
58MP0002736_abnormal_nociception_after1.37676137
59MP0001529_abnormal_vocalization1.36666581
60MP0002233_abnormal_nose_morphology1.35555581
61MP0000631_abnormal_neuroendocrine_gland1.34281308
62MP0002060_abnormal_skin_morphology1.31354771
63MP0001486_abnormal_startle_reflex1.30558312
64MP0001905_abnormal_dopamine_level1.30409225
65MP0005076_abnormal_cell_differentiation1.30040946
66MP0009053_abnormal_anal_canal1.29392860
67MP0001485_abnormal_pinna_reflex1.27268686
68MP0003861_abnormal_nervous_system1.26926931
69MP0009780_abnormal_chondrocyte_physiolo1.26006617
70MP0003453_abnormal_keratinocyte_physiol1.23027658
71MP0000026_abnormal_inner_ear1.22824947
72MP0009672_abnormal_birth_weight1.22043459
73MP0002272_abnormal_nervous_system1.21124777
74MP0002733_abnormal_thermal_nociception1.20517054
75MP0002752_abnormal_somatic_nervous1.20099960
76MP0002177_abnormal_outer_ear1.19060941
77MP0002572_abnormal_emotion/affect_behav1.18867221
78MP0000427_abnormal_hair_cycle1.18423496
79MP0002116_abnormal_craniofacial_bone1.17671425
80MP0004858_abnormal_nervous_system1.17370884
81MP0004782_abnormal_surfactant_physiolog1.16790965
82MP0001299_abnormal_eye_distance/1.16272892
83MP0004859_abnormal_synaptic_plasticity1.16230651
84MP0004742_abnormal_vestibular_system1.15892579
85MP0000534_abnormal_ureter_morphology1.15886543
86MP0002882_abnormal_neuron_morphology1.15603889
87MP0002063_abnormal_learning/memory/cond1.15453445
88MP0002067_abnormal_sensory_capabilities1.13194653
89MP0003787_abnormal_imprinting1.13141994
90MP0000762_abnormal_tongue_morphology1.12849557
91MP0004134_abnormal_chest_morphology1.12506197
92MP0001216_abnormal_epidermal_layer1.12070518
93MP0000955_abnormal_spinal_cord1.10971053
94MP0010771_integument_phenotype1.10696556
95MP0001970_abnormal_pain_threshold1.09844818
96MP0003566_abnormal_cell_adhesion1.09299903
97MP0002557_abnormal_social/conspecific_i1.09202627
98MP0000647_abnormal_sebaceous_gland1.05572393
99MP0005623_abnormal_meninges_morphology1.03393901
100MP0009745_abnormal_behavioral_response1.03390656
101MP0005377_hearing/vestibular/ear_phenot1.03309699
102MP0003878_abnormal_ear_physiology1.03309699
103MP0002152_abnormal_brain_morphology1.03056837
104MP0003115_abnormal_respiratory_system1.02865729
105MP0003890_abnormal_embryonic-extraembry1.02072777
106MP0003935_abnormal_craniofacial_develop1.01974896
107MP0000627_abnormal_mammary_gland1.01477687
108MP0002282_abnormal_trachea_morphology0.97853950
109MP0009384_cardiac_valve_regurgitation0.96502807
110MP0002932_abnormal_joint_morphology0.96451058
111MP0004145_abnormal_muscle_electrophysio0.94739944
112MP0009046_muscle_twitch0.94031118
113MP0002089_abnormal_postnatal_growth/wei0.93855430
114MP0001963_abnormal_hearing_physiology0.93469510
115MP0002092_abnormal_eye_morphology0.93222228
116MP0000751_myopathy0.92976819
117MP0005187_abnormal_penis_morphology0.92581168
118MP0000015_abnormal_ear_pigmentation0.91344897
119MP0005248_abnormal_Harderian_gland0.91079342
120MP0005367_renal/urinary_system_phenotyp0.91017362
121MP0000516_abnormal_urinary_system0.91017362
122MP0001286_abnormal_eye_development0.90565472
123MP0009703_decreased_birth_body0.90536992
124MP0004272_abnormal_basement_membrane0.89652692
125MP0002111_abnormal_tail_morphology0.89000099
126MP0003123_paternal_imprinting0.88904827
127MP0002909_abnormal_adrenal_gland0.88761295
128MP0002085_abnormal_embryonic_tissue0.87941994
129MP0002084_abnormal_developmental_patter0.87548983
130MP0002114_abnormal_axial_skeleton0.87306299
131MP0005197_abnormal_uvea_morphology0.87183550
132MP0001340_abnormal_eyelid_morphology0.87097620
133MP0000462_abnormal_digestive_system0.86056660
134MP0004885_abnormal_endolymph0.85558156
135MP0000432_abnormal_head_morphology0.85465629
136MP0004233_abnormal_muscle_weight0.85376520
137MP0001346_abnormal_lacrimal_gland0.85181231
138MP0005075_abnormal_melanosome_morpholog0.84943549
139MP0002064_seizures0.84924022
140MP0002081_perinatal_lethality0.84743105
141MP0000579_abnormal_nail_morphology0.84669828
142MP0000428_abnormal_craniofacial_morphol0.83729880
143MP0005408_hypopigmentation0.83237012
144MP0006072_abnormal_retinal_apoptosis0.82298819
145MP0000538_abnormal_urinary_bladder0.81834741
146MP0001293_anophthalmia0.81352748
147MP0003119_abnormal_digestive_system0.81173328
148MP0002109_abnormal_limb_morphology0.79678573
149MP0004811_abnormal_neuron_physiology0.79502046
150MP0005645_abnormal_hypothalamus_physiol0.79479810
151MP0001177_atelectasis0.79431715
152MP0002075_abnormal_coat/hair_pigmentati0.79406387
153MP0008932_abnormal_embryonic_tissue0.78836325
154MP0001186_pigmentation_phenotype0.76635138

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)3.70036434
2Atrophic scars (HP:0001075)3.66940411
3Right ventricular cardiomyopathy (HP:0011663)3.42399095
4Fragile nails (HP:0001808)3.25107518
5Hyperacusis (HP:0010780)3.12416227
6Milia (HP:0001056)3.10678312
7Ulnar claw (HP:0001178)2.93217130
8Hypothermia (HP:0002045)2.85796446
9Abnormality of the labia minora (HP:0012880)2.83968864
10Pili torti (HP:0003777)2.83717944
11Abnormality of the phalanges of the hallux (HP:0010057)2.77266983
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74518030
13Short 4th metacarpal (HP:0010044)2.74518030
14Limb dystonia (HP:0002451)2.68696743
15Onycholysis (HP:0001806)2.62588887
16Facial hemangioma (HP:0000329)2.59026562
17Adrenal hypoplasia (HP:0000835)2.57555838
18Plantar hyperkeratosis (HP:0007556)2.51097286
19Morphological abnormality of the middle ear (HP:0008609)2.48848865
20Microglossia (HP:0000171)2.40999805
21Septate vagina (HP:0001153)2.39027420
22Midline defect of the nose (HP:0004122)2.34624914
23Overriding aorta (HP:0002623)2.33478188
24Aplasia involving bones of the upper limbs (HP:0009823)2.31827373
25Aplasia of the phalanges of the hand (HP:0009802)2.31827373
26Aplasia involving bones of the extremities (HP:0009825)2.31827373
27Pterygium (HP:0001059)2.30545833
28Cutaneous finger syndactyly (HP:0010554)2.29009717
29Alacrima (HP:0000522)2.25353652
30Turricephaly (HP:0000262)2.23527145
31Germ cell neoplasia (HP:0100728)2.23125586
32Febrile seizures (HP:0002373)2.22685176
33Hepatoblastoma (HP:0002884)2.19831097
34Abnormality of the aortic arch (HP:0012303)2.17607454
35Alopecia of scalp (HP:0002293)2.17309195
36Shawl scrotum (HP:0000049)2.16336054
37Abnormal hair whorl (HP:0010721)2.16271226
38Parakeratosis (HP:0001036)2.15810567
39Absent eyelashes (HP:0000561)2.14867554
40Selective tooth agenesis (HP:0001592)2.13895412
41Abnormality of the corticospinal tract (HP:0002492)2.13395631
42Decreased lacrimation (HP:0000633)2.12522258
43Narrow nasal bridge (HP:0000446)2.08958834
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.07422061
45Hypotrichosis (HP:0001006)2.05757236
46Vertebral arch anomaly (HP:0008438)2.05146215
47Elfin facies (HP:0004428)2.03916751
48Renovascular hypertension (HP:0100817)2.03430465
49Atonic seizures (HP:0010819)2.02441740
50Hypopigmentation of the fundus (HP:0007894)2.01896040
51High anterior hairline (HP:0009890)2.01499767
52Insomnia (HP:0100785)2.00093809
53Abnormality of the salivary glands (HP:0010286)1.99174303
54Aplasia/Hypoplasia of the sternum (HP:0006714)1.98258284
55Curly hair (HP:0002212)1.98222238
56Advanced eruption of teeth (HP:0006288)1.98004643
57Abnormality of the nasolacrimal system (HP:0000614)1.96650346
58Progressive cerebellar ataxia (HP:0002073)1.95224659
59Back pain (HP:0003418)1.95146405
60Myelomeningocele (HP:0002475)1.95001658
61Abnormality of the lacrimal duct (HP:0011481)1.94953334
62Abnormality of the 4th metacarpal (HP:0010012)1.94535638
63Steppage gait (HP:0003376)1.93193334
64Degeneration of the lateral corticospinal tracts (HP:0002314)1.92569830
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92569830
66Cutaneous syndactyly (HP:0012725)1.92456277
67Focal motor seizures (HP:0011153)1.91226217
68Gait imbalance (HP:0002141)1.91075035
69Hypoplastic left heart (HP:0004383)1.90248042
70Renal hypoplasia (HP:0000089)1.89534949
71Ulnar bowing (HP:0003031)1.88646380
72Blue irides (HP:0000635)1.86222556
73Flat acetabular roof (HP:0003180)1.85935072
74Abnormality of incisor morphology (HP:0011063)1.84766838
75Absent frontal sinuses (HP:0002688)1.83925365
76Abnormal hair laboratory examination (HP:0003328)1.83249208
77Fragile skin (HP:0001030)1.82720054
78Nail dystrophy (HP:0008404)1.82128279
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81666322
80Genital tract atresia (HP:0001827)1.80897530
81Insidious onset (HP:0003587)1.80650971
82Termporal pattern (HP:0011008)1.80650971
83Thick nail (HP:0001805)1.80536681
84Shallow orbits (HP:0000586)1.80399149
85Abnormality of the dental root (HP:0006486)1.80364173
86Taurodontia (HP:0000679)1.80364173
87Abnormality of permanent molar morphology (HP:0011071)1.80364173
88Hypoplastic labia majora (HP:0000059)1.79284884
89Nasolacrimal duct obstruction (HP:0000579)1.79116698
90Heterochromia iridis (HP:0001100)1.79108689
91Buphthalmos (HP:0000557)1.78999946
92Coronal craniosynostosis (HP:0004440)1.78221679
93Concave nail (HP:0001598)1.77363442
94Bladder diverticulum (HP:0000015)1.76120720
95Arnold-Chiari malformation (HP:0002308)1.74785762
96Increased nuchal translucency (HP:0010880)1.74128932
97Lip pit (HP:0100267)1.74006850
98Vaginal atresia (HP:0000148)1.73747268
99Thin bony cortex (HP:0002753)1.73661260
100Renal duplication (HP:0000075)1.73369362
101Wrist flexion contracture (HP:0001239)1.73291172
102Esophageal atresia (HP:0002032)1.71345306
103Hypoplasia of dental enamel (HP:0006297)1.71222957
104Palmoplantar hyperkeratosis (HP:0000972)1.68893416
105Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68468463
106Hypoplasia of the brainstem (HP:0002365)1.68468463
107Embryonal renal neoplasm (HP:0011794)1.68159296
108Myokymia (HP:0002411)1.68013129
109Medial flaring of the eyebrow (HP:0010747)1.67711193
110Papillary thyroid carcinoma (HP:0002895)1.67697856
111Exostoses (HP:0100777)1.67337994
112Abnormality of the gastric mucosa (HP:0004295)1.66904986
113Bronchomalacia (HP:0002780)1.66534216
114Ridged nail (HP:0001807)1.65538449
115Atrioventricular canal defect (HP:0006695)1.65178554
116Intellectual disability, moderate (HP:0002342)1.65149378
117White forelock (HP:0002211)1.63862631
118Sleep apnea (HP:0010535)1.63705253
119Palmar hyperkeratosis (HP:0010765)1.63586809
120Deviation of the thumb (HP:0009603)1.63386064
121Nephroblastoma (Wilms tumor) (HP:0002667)1.63097521
122Asymmetry of the thorax (HP:0001555)1.63007587
123Hypoplastic heart (HP:0001961)1.62933918
124Abnormal lung lobation (HP:0002101)1.62841826
125Bicornuate uterus (HP:0000813)1.62772098
126Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62484122
127Abnormality of the parietal bone (HP:0002696)1.62000624
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.61840571
129Abnormality of dentin (HP:0010299)1.61564694
130Partial duplication of the phalanx of hand (HP:0009999)1.60942515
131Abnormality of molar (HP:0011077)1.60930616
132Abnormality of molar morphology (HP:0011070)1.60930616
133Hallux valgus (HP:0001822)1.60912456
134Fibular aplasia (HP:0002990)1.60391323
135Macroorchidism (HP:0000053)1.60385425
136Supernumerary spleens (HP:0009799)1.60318063
137Abnormality of the labia majora (HP:0012881)1.59848442
138Ankyloglossia (HP:0010296)1.59048722
139Hypoplastic pelvis (HP:0008839)1.59028646
140Tracheomalacia (HP:0002779)1.58912230
141Short tibia (HP:0005736)1.58792747
142Woolly hair (HP:0002224)1.58299419
143Deviation of the hallux (HP:0010051)1.58205724
144Broad-based gait (HP:0002136)1.57973504
145Exotropia (HP:0000577)1.57943590
146Abnormality of the pubic bones (HP:0003172)1.57816214
147Abnormality of the axillary hair (HP:0100134)1.57505469
148Abnormality of secondary sexual hair (HP:0009888)1.57505469
149Patellar dislocation (HP:0002999)1.57401676
150Long nose (HP:0003189)1.57138450
151Anophthalmia (HP:0000528)1.56088633
152Fetal akinesia sequence (HP:0001989)1.56076815
153Abnormality of the distal phalanges of the toes (HP:0010182)1.55978649
154Focal seizures (HP:0007359)1.55978469
155Preaxial foot polydactyly (HP:0001841)1.55890217
156J-shaped sella turcica (HP:0002680)1.55441610
157Breast carcinoma (HP:0003002)1.55350577
158Broad ribs (HP:0000885)1.55116426
159Leiomyosarcoma (HP:0100243)1.54875662
160Uterine leiomyosarcoma (HP:0002891)1.54875662
161Cerebral inclusion bodies (HP:0100314)1.53800165
162Abnormality of the septum pellucidum (HP:0007375)1.53715651
163Atelectasis (HP:0100750)1.53292072
164Drooling (HP:0002307)1.53178324
165Excessive salivation (HP:0003781)1.53178324
166Humeroradial synostosis (HP:0003041)1.53043198
167Synostosis involving the elbow (HP:0003938)1.53043198
168Natal tooth (HP:0000695)1.52067283
169Sclerocornea (HP:0000647)1.50800267
170Absent septum pellucidum (HP:0001331)1.49606788
171Absent eyebrow (HP:0002223)1.49527178
172Nonprogressive disorder (HP:0003680)1.49466510
173Bifid tongue (HP:0010297)1.49043471
174Anencephaly (HP:0002323)1.49003798
175Complete atrioventricular canal defect (HP:0001674)1.48859832
176Aplasia/Hypoplasia of the patella (HP:0006498)1.47777106
177Choanal stenosis (HP:0000452)1.47751156
178Preaxial hand polydactyly (HP:0001177)1.47701796
179Renal dysplasia (HP:0000110)1.47557126
180Aplasia cutis congenita (HP:0001057)1.47370340
181Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.47310436
182Patellar aplasia (HP:0006443)1.45893232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.92006551
2TRIB34.73647863
3MARK14.40611925
4MUSK3.78164126
5PKN23.66374404
6MAPK133.45842285
7EPHA23.15650800
8DYRK22.85524481
9SIK12.55669584
10EEF2K2.54581960
11TNIK2.43005229
12MKNK22.30674707
13MKNK12.14112341
14SRPK12.11806482
15MAP2K72.10048243
16NTRK22.07508406
17ICK2.00846831
18CDK121.96409195
19RPS6KB21.89970459
20RIPK11.88838573
21MAP3K101.76728814
22MAPKAPK31.75978943
23FGFR21.64730894
24PDGFRA1.63345010
25UHMK11.62941666
26PNCK1.62216111
27MAP3K41.62068617
28LIMK11.60821064
29EPHB21.60586613
30TYRO31.60213747
31ERBB31.57969649
32SMG11.53897200
33FGFR41.52136274
34MST1R1.50435058
35MET1.49840073
36CSNK1G31.41887274
37PLK21.41874849
38MAP3K91.38679585
39SCYL21.34248090
40NTRK31.34007770
41AKT31.33737057
42PHKG11.29030209
43PHKG21.29030209
44LATS21.28921458
45EPHA31.28035484
46STK391.27884505
47BMPR1B1.27833104
48PTK21.27212660
49CSNK1G11.26656924
50YES11.23993443
51PTK61.23308506
52PAK41.20117519
53MTOR1.16850968
54PKN11.15852230
55CSNK1A1L1.14777292
56BCR1.14507537
57BRD41.13693616
58RET1.13298773
59NEK61.13169586
60DDR21.11298932
61CSNK1G21.10559297
62MINK11.05994401
63STK241.02012026
64SGK4940.99702034
65SGK2230.99702034
66LMTK20.97672627
67PIK3CA0.95313696
68PRPF4B0.95280192
69DYRK1A0.95191267
70CAMK1G0.92611122
71ERBB40.88912292
72ILK0.87804194
73LATS10.87778561
74SGK20.85760292
75ROCK10.84455856
76ARAF0.83504434
77PRKCE0.83128939
78FGFR10.81118661
79CAMK2B0.80734349
80SIK20.80335580
81CDK70.80239782
82BRAF0.79926873
83EIF2AK20.79549244
84GRK70.79380067
85DMPK0.78148833
86ERBB20.76044174
87ADRBK10.75478326
88WEE10.75453520
89CAMK2A0.74902893
90CDK80.73178459
91STK38L0.73177001
92RPS6KB10.72270995
93GRK50.72093798
94ADRBK20.69632660
95EPHA40.69096862
96MAP2K20.67440253
97FGR0.66938108
98PLK30.66887903
99KSR10.66563459
100NTRK10.66440582
101RPS6KA20.66205995
102TTK0.64501565
103MAP3K20.64350288
104PBK0.64168402
105CDK30.63118312
106VRK10.61792134
107ROCK20.61265557
108AKT20.61092760
109CDK50.59561989
110CAMK1D0.59416029
111PRKCI0.59137279
112WNK30.58499770
113IRAK20.57476235
114PRKCG0.57222756
115OXSR10.56154906
116PRKD30.55422911
117NUAK10.55239124
118CDK140.55180536
119STK160.54868581
120PLK40.54601712
121PAK30.51851885
122TSSK60.51802710
123TESK10.51670330
124MAP3K60.50974481
125FER0.49745684
126PRKCZ0.49240663
127CDK180.49127350
128RPS6KA10.47019057
129PDGFRB0.46884249
130CDK150.46208759
131CSNK1E0.46064525
132WNK40.46037514
133BMPR20.46013416
134AURKA0.44840675
135RPS6KA40.44190094
136TLK10.44003133
137MAPK90.43774118
138RPS6KL10.42907058
139RPS6KC10.42907058
140CDK11A0.42123893
141MAP3K120.41926639
142PIM20.41895440
143TRIM280.41664997
144KSR20.41467014
145TTN0.41356757
146MAP2K40.40872372
147CHUK0.39995567
148PRKACA0.38987223
149MYLK0.38981690
150MAPKAPK50.37652757
151MARK20.37551688
152NLK0.37131248
153CAMK40.36692689
154PRKG10.36560516
155MATK0.35704506
156PAK60.35602728
157NME10.35367393
158CHEK20.34874582
159LRRK20.34504183
160GSK3B0.31949427
161SGK30.31856950

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.61065966
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44662453
3Nicotine addiction_Homo sapiens_hsa050332.27440788
4Thyroid cancer_Homo sapiens_hsa052162.13262273
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08181835
6Oxidative phosphorylation_Homo sapiens_hsa001902.03560751
7Hedgehog signaling pathway_Homo sapiens_hsa043401.98416488
8Basal cell carcinoma_Homo sapiens_hsa052171.95380691
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94975618
10Central carbon metabolism in cancer_Homo sapiens_hsa052301.92818065
11Parkinsons disease_Homo sapiens_hsa050121.83111668
12Serotonergic synapse_Homo sapiens_hsa047261.78300806
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.67421459
14Olfactory transduction_Homo sapiens_hsa047401.65906600
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63780463
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59034132
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57230896
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57107708
19Glutamatergic synapse_Homo sapiens_hsa047241.54008985
20Huntingtons disease_Homo sapiens_hsa050161.53982173
21Alzheimers disease_Homo sapiens_hsa050101.51582194
22Wnt signaling pathway_Homo sapiens_hsa043101.45635843
23Cardiac muscle contraction_Homo sapiens_hsa042601.45582485
24Taste transduction_Homo sapiens_hsa047421.45503216
25Dopaminergic synapse_Homo sapiens_hsa047281.44831635
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39758730
27Cholinergic synapse_Homo sapiens_hsa047251.35834267
28Phototransduction_Homo sapiens_hsa047441.35831366
29Long-term depression_Homo sapiens_hsa047301.35796665
30Small cell lung cancer_Homo sapiens_hsa052221.34101307
31Basal transcription factors_Homo sapiens_hsa030221.29341416
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28872038
33Melanogenesis_Homo sapiens_hsa049161.26739269
34Circadian entrainment_Homo sapiens_hsa047131.24257757
35Estrogen signaling pathway_Homo sapiens_hsa049151.23047991
36Hippo signaling pathway_Homo sapiens_hsa043901.22295185
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21604302
38Chronic myeloid leukemia_Homo sapiens_hsa052201.21316980
39Morphine addiction_Homo sapiens_hsa050321.20901603
40GABAergic synapse_Homo sapiens_hsa047271.20452127
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20249390
42Colorectal cancer_Homo sapiens_hsa052101.15159728
43AMPK signaling pathway_Homo sapiens_hsa041521.14279766
44Gap junction_Homo sapiens_hsa045401.13913903
45Proteoglycans in cancer_Homo sapiens_hsa052051.13233539
46Steroid biosynthesis_Homo sapiens_hsa001001.10614570
47Bladder cancer_Homo sapiens_hsa052191.09783264
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08266291
49Insulin signaling pathway_Homo sapiens_hsa049101.08029804
50VEGF signaling pathway_Homo sapiens_hsa043701.07389762
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06408344
52Melanoma_Homo sapiens_hsa052181.05569577
53Synaptic vesicle cycle_Homo sapiens_hsa047211.04927206
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03625704
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02953921
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02874925
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02048321
58ErbB signaling pathway_Homo sapiens_hsa040121.01399251
59Non-small cell lung cancer_Homo sapiens_hsa052231.00083523
60RNA polymerase_Homo sapiens_hsa030201.00010428
61ECM-receptor interaction_Homo sapiens_hsa045120.99678568
62Lysine degradation_Homo sapiens_hsa003100.99215905
63Cocaine addiction_Homo sapiens_hsa050300.98672545
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97830933
65Dilated cardiomyopathy_Homo sapiens_hsa054140.95363790
66Endometrial cancer_Homo sapiens_hsa052130.94975807
67Proteasome_Homo sapiens_hsa030500.94785471
68Ether lipid metabolism_Homo sapiens_hsa005650.94551435
69Tight junction_Homo sapiens_hsa045300.94044205
70Collecting duct acid secretion_Homo sapiens_hsa049660.93351543
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91805142
72Amphetamine addiction_Homo sapiens_hsa050310.91265953
73Choline metabolism in cancer_Homo sapiens_hsa052310.90583225
74Prolactin signaling pathway_Homo sapiens_hsa049170.89601540
75Alcoholism_Homo sapiens_hsa050340.89575315
76Ribosome_Homo sapiens_hsa030100.89424544
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88995111
78Ras signaling pathway_Homo sapiens_hsa040140.88508392
79mTOR signaling pathway_Homo sapiens_hsa041500.87307730
80Oocyte meiosis_Homo sapiens_hsa041140.87131931
81Spliceosome_Homo sapiens_hsa030400.86944177
82TGF-beta signaling pathway_Homo sapiens_hsa043500.85480357
83Ovarian steroidogenesis_Homo sapiens_hsa049130.85160648
84Long-term potentiation_Homo sapiens_hsa047200.84744490
85GnRH signaling pathway_Homo sapiens_hsa049120.81872531
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.81598867
87Pancreatic cancer_Homo sapiens_hsa052120.81138532
88MicroRNAs in cancer_Homo sapiens_hsa052060.80769213
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80578010
90Amoebiasis_Homo sapiens_hsa051460.80143180
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79580798
92Pathways in cancer_Homo sapiens_hsa052000.79467130
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78299226
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78125032
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76512145
96Renal cell carcinoma_Homo sapiens_hsa052110.76421933
97Inositol phosphate metabolism_Homo sapiens_hsa005620.76321404
98Biosynthesis of amino acids_Homo sapiens_hsa012300.76304331
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75338660
100Calcium signaling pathway_Homo sapiens_hsa040200.73657918
101Prostate cancer_Homo sapiens_hsa052150.73469605
102mRNA surveillance pathway_Homo sapiens_hsa030150.72786850
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.72429017
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72399869
105Galactose metabolism_Homo sapiens_hsa000520.70875386
106Oxytocin signaling pathway_Homo sapiens_hsa049210.70618904
107Bile secretion_Homo sapiens_hsa049760.70345813
108Renin secretion_Homo sapiens_hsa049240.70217611
109Fructose and mannose metabolism_Homo sapiens_hsa000510.70119594
110RNA degradation_Homo sapiens_hsa030180.69710988
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67394288
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66178805
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66007312
114Thyroid hormone synthesis_Homo sapiens_hsa049180.65792089
115Insulin secretion_Homo sapiens_hsa049110.65547449
116Prion diseases_Homo sapiens_hsa050200.64726853
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.63350546
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63272300
119Vibrio cholerae infection_Homo sapiens_hsa051100.62759733
120Rap1 signaling pathway_Homo sapiens_hsa040150.62591530
121Adherens junction_Homo sapiens_hsa045200.62128793
122Cell cycle_Homo sapiens_hsa041100.60875279
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.60589580
124Fanconi anemia pathway_Homo sapiens_hsa034600.60557631
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60452956
126Focal adhesion_Homo sapiens_hsa045100.58960734
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58361932
128Dorso-ventral axis formation_Homo sapiens_hsa043200.58055662
129N-Glycan biosynthesis_Homo sapiens_hsa005100.57615238
130Glucagon signaling pathway_Homo sapiens_hsa049220.56910474
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56420825
132MAPK signaling pathway_Homo sapiens_hsa040100.56253045
133Acute myeloid leukemia_Homo sapiens_hsa052210.56213747
134Sphingolipid metabolism_Homo sapiens_hsa006000.56198303
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55216568
136Notch signaling pathway_Homo sapiens_hsa043300.55202656
137Pentose phosphate pathway_Homo sapiens_hsa000300.54816807
138cAMP signaling pathway_Homo sapiens_hsa040240.52127807
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51528043
140Viral myocarditis_Homo sapiens_hsa054160.51380805
141Salivary secretion_Homo sapiens_hsa049700.50166313
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50016522
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49444935
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49414368
145Protein digestion and absorption_Homo sapiens_hsa049740.49332412
146Glioma_Homo sapiens_hsa052140.48150337
147Type II diabetes mellitus_Homo sapiens_hsa049300.47651358

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