IGSF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.17901696
2synapsis (GO:0007129)8.78981439
3DNA methylation involved in gamete generation (GO:0043046)7.58183958
4L-phenylalanine catabolic process (GO:0006559)6.69683576
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.69683576
6chromosome organization involved in meiosis (GO:0070192)6.48958973
7L-phenylalanine metabolic process (GO:0006558)6.47699840
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.47699840
9regulation of meiosis I (GO:0060631)6.37239070
10male meiosis I (GO:0007141)6.04188781
11aromatic amino acid family catabolic process (GO:0009074)6.01808140
12cysteine metabolic process (GO:0006534)5.80550746
13male meiosis (GO:0007140)5.78047641
14meiotic chromosome segregation (GO:0045132)5.65548218
15sulfur amino acid catabolic process (GO:0000098)5.50435963
16indole-containing compound catabolic process (GO:0042436)5.44074338
17indolalkylamine catabolic process (GO:0046218)5.44074338
18tryptophan catabolic process (GO:0006569)5.44074338
19glyoxylate metabolic process (GO:0046487)5.29901018
20kynurenine metabolic process (GO:0070189)5.26063560
21resolution of meiotic recombination intermediates (GO:0000712)5.25701583
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.21779689
23cellular ketone body metabolic process (GO:0046950)5.20891358
24tryptophan metabolic process (GO:0006568)5.15462076
25synaptonemal complex assembly (GO:0007130)5.11401894
26homocysteine metabolic process (GO:0050667)5.00986527
27bile acid biosynthetic process (GO:0006699)4.92568447
28lysine catabolic process (GO:0006554)4.90120505
29lysine metabolic process (GO:0006553)4.90120505
30meiosis I (GO:0007127)4.83991773
31bile acid and bile salt transport (GO:0015721)4.78298408
32urea cycle (GO:0000050)4.76420229
33urea metabolic process (GO:0019627)4.76420229
34meiotic nuclear division (GO:0007126)4.75940344
35gene silencing by RNA (GO:0031047)4.73796780
36alpha-linolenic acid metabolic process (GO:0036109)4.72666539
37synaptonemal complex organization (GO:0070193)4.66902349
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.63039296
39drug transmembrane transport (GO:0006855)4.56158454
40flavonoid metabolic process (GO:0009812)4.55565313
41high-density lipoprotein particle remodeling (GO:0034375)4.54570529
42serine family amino acid catabolic process (GO:0009071)4.50665034
43ketone body metabolic process (GO:1902224)4.50413506
44bile acid metabolic process (GO:0008206)4.50209272
45drug catabolic process (GO:0042737)4.49684030
46DNA synthesis involved in DNA repair (GO:0000731)4.42208946
47aromatic amino acid family metabolic process (GO:0009072)4.40035998
48nitrogen cycle metabolic process (GO:0071941)4.39727702
49cellular glucuronidation (GO:0052695)4.29830369
50meiotic cell cycle process (GO:1903046)4.27806129
51amino-acid betaine metabolic process (GO:0006577)4.27690338
52oxidative demethylation (GO:0070989)4.26858447
53sister chromatid cohesion (GO:0007062)4.26598727
54meiotic cell cycle (GO:0051321)4.25704718
55negative regulation of fibrinolysis (GO:0051918)4.25232537
56regulation of triglyceride catabolic process (GO:0010896)4.24486101
57negative regulation of cholesterol transport (GO:0032375)4.22914062
58negative regulation of sterol transport (GO:0032372)4.22914062
59protein carboxylation (GO:0018214)4.21406438
60peptidyl-glutamic acid carboxylation (GO:0017187)4.21406438
61intestinal cholesterol absorption (GO:0030299)4.20545780
62complement activation, alternative pathway (GO:0006957)4.16402453
63reverse cholesterol transport (GO:0043691)4.13902420
64alpha-amino acid catabolic process (GO:1901606)4.12522540
65acylglycerol homeostasis (GO:0055090)4.11542736
66triglyceride homeostasis (GO:0070328)4.11542736
67reciprocal meiotic recombination (GO:0007131)4.10073811
68reciprocal DNA recombination (GO:0035825)4.10073811
69urate metabolic process (GO:0046415)4.09830267
70regulation of cholesterol esterification (GO:0010872)4.08863696
71regulation of protein activation cascade (GO:2000257)4.06287072
72regulation of fibrinolysis (GO:0051917)4.05438624
73regulation of bile acid biosynthetic process (GO:0070857)4.03571667
74protein-lipid complex remodeling (GO:0034368)4.02939015
75macromolecular complex remodeling (GO:0034367)4.02939015
76plasma lipoprotein particle remodeling (GO:0034369)4.02939015
77cellular modified amino acid catabolic process (GO:0042219)4.01602096
78phospholipid efflux (GO:0033700)4.01226989
79cellular amino acid catabolic process (GO:0009063)3.97219577
80glucuronate metabolic process (GO:0019585)3.95635518
81uronic acid metabolic process (GO:0006063)3.95635518
82ethanol oxidation (GO:0006069)3.92912396
83tyrosine metabolic process (GO:0006570)3.90573302
84indolalkylamine metabolic process (GO:0006586)3.88725604
85serine family amino acid metabolic process (GO:0009069)3.87630238
86glutamate metabolic process (GO:0006536)3.85662045
87short-chain fatty acid metabolic process (GO:0046459)3.85595758
88response to nitrosative stress (GO:0051409)3.85287654
89benzene-containing compound metabolic process (GO:0042537)3.84565814
90exogenous drug catabolic process (GO:0042738)3.83415550
91drug transport (GO:0015893)3.80954463
92regulation of complement activation (GO:0030449)3.80438781
93intestinal absorption (GO:0050892)3.78927659
94regulation of cholesterol homeostasis (GO:2000188)3.76117609
95aldehyde catabolic process (GO:0046185)3.75229217
96positive regulation of meiosis (GO:0045836)3.74723171
97monoubiquitinated protein deubiquitination (GO:0035520)3.71511775
98cellular biogenic amine catabolic process (GO:0042402)3.69798358
99amine catabolic process (GO:0009310)3.69798358
100coenzyme catabolic process (GO:0009109)3.64279657
101drug metabolic process (GO:0017144)3.62080894
102fatty acid oxidation (GO:0019395)3.60655283
103regulation of DNA endoreduplication (GO:0032875)3.59381663
104cholesterol efflux (GO:0033344)3.57769393
105fatty acid beta-oxidation (GO:0006635)3.57593411
106plasma lipoprotein particle assembly (GO:0034377)3.55859033
107organic acid catabolic process (GO:0016054)3.55560060
108carboxylic acid catabolic process (GO:0046395)3.55560060
109cholesterol homeostasis (GO:0042632)3.54848482
110lipid oxidation (GO:0034440)3.53549918
111aspartate family amino acid catabolic process (GO:0009068)3.53223850
112positive regulation of meiotic cell cycle (GO:0051446)3.52990851
113serine family amino acid biosynthetic process (GO:0009070)3.52812041
114sterol homeostasis (GO:0055092)3.52064558
115glycine metabolic process (GO:0006544)3.51601785
116positive regulation of lipoprotein lipase activity (GO:0051006)3.51053514
117positive regulation of triglyceride lipase activity (GO:0061365)3.51053514
118plasma lipoprotein particle clearance (GO:0034381)3.47124797
119DNA alkylation (GO:0006305)3.45322924
120DNA methylation (GO:0006306)3.45322924
121DNA double-strand break processing (GO:0000729)3.42479559
122monocarboxylic acid catabolic process (GO:0072329)3.39241072
123fatty acid catabolic process (GO:0009062)3.38689730
124fructose metabolic process (GO:0006000)3.38679220
125valine metabolic process (GO:0006573)3.38638705
126very-low-density lipoprotein particle assembly (GO:0034379)3.36904183
127lipoprotein metabolic process (GO:0042157)3.34902093
128phospholipid homeostasis (GO:0055091)3.33188166
129negative regulation of DNA-dependent DNA replication (GO:2000104)3.26461140
130somatic hypermutation of immunoglobulin genes (GO:0016446)3.25394644
131somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25394644
132mitotic sister chromatid cohesion (GO:0007064)3.17071218
133DNA methylation or demethylation (GO:0044728)3.15407170
134gonadal mesoderm development (GO:0007506)3.02107575
135DNA catabolic process, exonucleolytic (GO:0000738)3.00350641
136histone H2A acetylation (GO:0043968)2.99010422
137cilium or flagellum-dependent cell motility (GO:0001539)2.98906505
138pre-miRNA processing (GO:0031054)2.97413623
139protein K11-linked deubiquitination (GO:0035871)2.96583246
140histone mRNA catabolic process (GO:0071044)2.95756648
141female gamete generation (GO:0007292)2.95202068
142centriole replication (GO:0007099)2.92779398
143regulation of posttranscriptional gene silencing (GO:0060147)2.92762680
144regulation of gene silencing by miRNA (GO:0060964)2.92762680
145regulation of gene silencing by RNA (GO:0060966)2.92762680
146mitotic spindle checkpoint (GO:0071174)2.91973708
147interkinetic nuclear migration (GO:0022027)2.91609411
148gene silencing (GO:0016458)2.87954592
149histone exchange (GO:0043486)2.87420763
150intra-S DNA damage checkpoint (GO:0031573)2.86264034
151chromatin remodeling at centromere (GO:0031055)2.85493321
152sex differentiation (GO:0007548)2.85431735
153proteasome assembly (GO:0043248)2.81780304
154CENP-A containing nucleosome assembly (GO:0034080)2.78778546
155microtubule anchoring (GO:0034453)2.78762537
156spindle checkpoint (GO:0031577)2.75205577
157DNA modification (GO:0006304)2.75095610
158attachment of spindle microtubules to kinetochore (GO:0008608)2.72397910
159mitotic spindle assembly checkpoint (GO:0007094)2.70411575
160negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68803735
161negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68803735
162negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68803735
163negative regulation of mitotic sister chromatid separation (GO:2000816)2.68803735
164negative regulation of sister chromatid segregation (GO:0033046)2.68803735
165photoreceptor cell maintenance (GO:0045494)2.68272288
166negative regulation of chromosome segregation (GO:0051985)2.65673029
167spindle assembly checkpoint (GO:0071173)2.64201187
168histone H3-K36 demethylation (GO:0070544)2.61525373
169double-strand break repair via nonhomologous end joining (GO:0006303)2.60055266
170non-recombinational repair (GO:0000726)2.60055266
171double-strand break repair via homologous recombination (GO:0000724)2.59978905
172recombinational repair (GO:0000725)2.57704341
173regulation of mitotic sister chromatid separation (GO:0010965)2.57265059
174regulation of mitotic sister chromatid segregation (GO:0033047)2.57265059
175regulation of sister chromatid segregation (GO:0033045)2.57265059
176binding of sperm to zona pellucida (GO:0007339)2.56103803
177fertilization (GO:0009566)2.55392405
178oogenesis (GO:0048477)2.55391310
179protein K48-linked deubiquitination (GO:0071108)2.55110074
180metaphase plate congression (GO:0051310)2.54472577
181regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54363298
182regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54363298
183detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52208659
184histone H4-K12 acetylation (GO:0043983)2.51761932
185regulation of centriole replication (GO:0046599)2.51577761
186spermatid development (GO:0007286)2.50929817
187negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.50744791
188centriole assembly (GO:0098534)2.48942482
189signal peptide processing (GO:0006465)2.48387507
190mitotic metaphase plate congression (GO:0007080)2.48201377
191response to misfolded protein (GO:0051788)2.46021962
192regulation of meiotic cell cycle (GO:0051445)2.42587405
193nuclear pore organization (GO:0006999)2.38786956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.38206311
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.54780399
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.83649291
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.77043764
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74314838
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.47422905
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.29924112
8IGF1R_20145208_ChIP-Seq_DFB_Human4.08788317
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.58635664
10VDR_22108803_ChIP-Seq_LS180_Human3.40840996
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.21665220
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.10385479
13ZNF274_21170338_ChIP-Seq_K562_Hela2.87177966
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.63043029
15EZH2_22144423_ChIP-Seq_EOC_Human2.61973638
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57725746
17GBX2_23144817_ChIP-Seq_PC3_Human2.56070874
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52344901
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29785626
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.22862006
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10414679
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05775254
23FUS_26573619_Chip-Seq_HEK293_Human2.01851776
24CLOCK_20551151_ChIP-Seq_293T_Human2.00197922
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2833323
26ER_23166858_ChIP-Seq_MCF-7_Human1.99718679
27TAF15_26573619_Chip-Seq_HEK293_Human1.99696544
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97696543
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97178041
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96170672
31P300_19829295_ChIP-Seq_ESCs_Human1.91972147
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91699644
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88281192
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85061354
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84729039
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84569247
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.83008417
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82204534
39GATA4_25053715_ChIP-Seq_YYC3_Human1.80869027
40STAT3_23295773_ChIP-Seq_U87_Human1.79952794
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79266604
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.77311045
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76047527
44EWS_26573619_Chip-Seq_HEK293_Human1.75435183
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.73410358
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73097866
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70090268
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69534793
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.67650852
50E2F7_22180533_ChIP-Seq_HELA_Human1.66362711
51* TCF4_23295773_ChIP-Seq_U87_Human1.59783815
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.57676944
53SMAD4_21799915_ChIP-Seq_A2780_Human1.52448300
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51497588
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.50939892
56HNF4A_19822575_ChIP-Seq_HepG2_Human1.50732544
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50215507
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49290675
59BCAT_22108803_ChIP-Seq_LS180_Human1.49230343
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47959235
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46739439
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45191921
63GATA1_22025678_ChIP-Seq_K562_Human1.44917626
64* RUNX2_22187159_ChIP-Seq_PCA_Human1.42775001
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.40143746
66ELK1_19687146_ChIP-ChIP_HELA_Human1.39036760
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39036308
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38636839
69CBP_20019798_ChIP-Seq_JUKART_Human1.38636839
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38374175
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37504944
72GATA6_25053715_ChIP-Seq_YYC3_Human1.36611650
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33985138
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33239034
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.32015342
76SOX2_20726797_ChIP-Seq_SW620_Human1.30906241
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29023222
78TP53_22573176_ChIP-Seq_HFKS_Human1.28945198
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27169054
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26554900
81AR_25329375_ChIP-Seq_VCAP_Human1.22731509
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22400445
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.21914076
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21628159
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21494523
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21494523
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.19987850
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19449835
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19216973
90AR_21572438_ChIP-Seq_LNCaP_Human1.19196968
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17423187
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16922868
93TCF4_22108803_ChIP-Seq_LS180_Human1.16471285
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.16269612
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16244919
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15889265
97HTT_18923047_ChIP-ChIP_STHdh_Human1.14158795
98RNF2_27304074_Chip-Seq_NSC_Mouse1.13306050
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.13030804
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.12442653
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12442653
102VDR_23849224_ChIP-Seq_CD4+_Human1.11785452
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10668638
104SOX2_19829295_ChIP-Seq_ESCs_Human1.10482713
105NANOG_19829295_ChIP-Seq_ESCs_Human1.10482713
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.09899429
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08477151
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08271355
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07846577
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07065439
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.06836943
112IRF1_19129219_ChIP-ChIP_H3396_Human1.06662820
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05477209
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.05163327
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04278236
116HOXB7_26014856_ChIP-Seq_BT474_Human1.03783017
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.03342239
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02907156
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99202145
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.98786139
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98661278
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98585583
123TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98181733
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97220792
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96899225
126FOXP3_21729870_ChIP-Seq_TREG_Human0.96571028
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96524170
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.96386820
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94493999
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94372834
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93927693
132FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93900594
133* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93252875
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92603622
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91702877
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91040358
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.90897160
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90800375
139NFE2_27457419_Chip-Seq_LIVER_Mouse0.89697616
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89230043
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88689760
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.88485489
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88176621
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87936842
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87384191
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86836054
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.85930776
148ZNF263_19887448_ChIP-Seq_K562_Human0.84746717
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.83779128
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79752727
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78692705
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78584099
153RACK7_27058665_Chip-Seq_MCF-7_Human0.78094699
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78064562
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78064562
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77502207
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75747695
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75588217
159IRF8_22096565_ChIP-ChIP_GC-B_Human0.72650620
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71892998
161ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70647203
162KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70602719
163PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69895280
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.69537967
165SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68539088
166LXR_22292898_ChIP-Seq_THP-1_Human0.68165734
167RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67984175
168KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67370506
169EGR1_19032775_ChIP-ChIP_M12_Human0.66683323
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65041732
171FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64594351
172KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64052492
173GATA2_19941826_ChIP-Seq_K562_Human0.63118110
174CDX2_22108803_ChIP-Seq_LS180_Human0.63112954
175AR_20517297_ChIP-Seq_VCAP_Human0.61587047
176ATF3_27146783_Chip-Seq_COLON_Human0.60958374
177MYC_19915707_ChIP-ChIP_AK7_Human0.60113293
178SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.59445226
179PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58685085
180GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57879227
181RARB_24833708_ChIP-Seq_LIVER_Mouse0.57316893
182* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57166738
183TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56724288
184SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56174267
185CEBPB_22108803_ChIP-Seq_LS180_Human0.55977916
186GATA2_21666600_ChIP-Seq_HMVEC_Human0.54128745
187P63_26484246_Chip-Seq_KERATINOCYTES_Human0.53542133
188RUNX1_27514584_Chip-Seq_MCF-7_Human0.53299677
189CREB1_26743006_Chip-Seq_LNCaP_Human0.53245347
190CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.53093797
191GATA1_19941826_ChIP-Seq_K562_Human0.52991100
192ESET_19884257_ChIP-Seq_ESCs_Mouse0.52295265
193* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.51928565
194* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.51750443
195SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51432902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.60367195
2MP0005360_urolithiasis7.37047030
3MP0005085_abnormal_gallbladder_physiolo5.73994721
4MP0005365_abnormal_bile_salt5.47423999
5MP0008877_abnormal_DNA_methylation5.02208971
6MP0008875_abnormal_xenobiotic_pharmacok4.76125239
7MP0003252_abnormal_bile_duct3.81728619
8MP0008057_abnormal_DNA_replication3.65198417
9MP0003136_yellow_coat_color3.53484735
10MP0001666_abnormal_nutrient_absorption3.48065695
11MP0003806_abnormal_nucleotide_metabolis3.45796403
12MP0008058_abnormal_DNA_repair3.32841570
13MP0010329_abnormal_lipoprotein_level3.01723112
14MP0005332_abnormal_amino_acid2.87692874
15MP0005083_abnormal_biliary_tract2.77771558
16MP0003195_calcinosis2.73055808
17MP0002138_abnormal_hepatobiliary_system2.67662650
18MP0004019_abnormal_vitamin_homeostasis2.66992304
19MP0006292_abnormal_olfactory_placode2.54678412
20MP0000372_irregular_coat_pigmentation2.51493443
21MP0000569_abnormal_digit_pigmentation2.50086022
22MP0009840_abnormal_foam_cell2.49967110
23MP0003718_maternal_effect2.47313329
24MP0003646_muscle_fatigue2.46164609
25MP0010094_abnormal_chromosome_stability2.43914284
26MP0002210_abnormal_sex_determination2.41492744
27MP0001929_abnormal_gametogenesis2.33388475
28MP0004147_increased_porphyrin_level2.20425158
29MP0003693_abnormal_embryo_hatching2.18198049
30MP0003191_abnormal_cellular_cholesterol2.14037146
31MP0003868_abnormal_feces_composition2.01303124
32MP0009643_abnormal_urine_homeostasis1.97915651
33MP0002837_dystrophic_cardiac_calcinosis1.94118474
34MP0001145_abnormal_male_reproductive1.92731701
35MP0003698_abnormal_male_reproductive1.92509880
36MP0000653_abnormal_sex_gland1.91534091
37MP0002118_abnormal_lipid_homeostasis1.89126215
38MP0008995_early_reproductive_senescence1.84163611
39MP0000609_abnormal_liver_physiology1.82957309
40MP0005174_abnormal_tail_pigmentation1.80759553
41MP0004043_abnormal_pH_regulation1.79246851
42MP0002160_abnormal_reproductive_system1.74578059
43MP0010234_abnormal_vibrissa_follicle1.72436178
44MP0005319_abnormal_enzyme/_coenzyme1.66544546
45MP0002938_white_spotting1.56369341
46MP0005636_abnormal_mineral_homeostasis1.55698900
47MP0005551_abnormal_eye_electrophysiolog1.54145269
48MP0004957_abnormal_blastocyst_morpholog1.48605404
49MP0006276_abnormal_autonomic_nervous1.47698457
50MP0005171_absent_coat_pigmentation1.47222168
51MP0000015_abnormal_ear_pigmentation1.45369065
52MP0003890_abnormal_embryonic-extraembry1.43330321
53MP0002102_abnormal_ear_morphology1.42600848
54MP0005423_abnormal_somatic_nervous1.41406099
55MP0005451_abnormal_body_composition1.41167283
56MP0005084_abnormal_gallbladder_morpholo1.40842900
57MP0001986_abnormal_taste_sensitivity1.40481398
58MP0001764_abnormal_homeostasis1.40263456
59MP0005584_abnormal_enzyme/coenzyme_acti1.38896587
60MP0003077_abnormal_cell_cycle1.38763543
61MP0004264_abnormal_extraembryonic_tissu1.38418444
62MP0002095_abnormal_skin_pigmentation1.31847861
63MP0001756_abnormal_urination1.30310545
64MP0004215_abnormal_myocardial_fiber1.27747737
65MP0005075_abnormal_melanosome_morpholog1.23965476
66MP0004084_abnormal_cardiac_muscle1.23555153
67MP0000383_abnormal_hair_follicle1.23547305
68MP0003186_abnormal_redox_activity1.20991323
69MP0004145_abnormal_muscle_electrophysio1.20532338
70MP0003111_abnormal_nucleus_morphology1.19142035
71MP0005410_abnormal_fertilization1.17979886
72MP0005646_abnormal_pituitary_gland1.16283824
73MP0001765_abnormal_ion_homeostasis1.15330175
74MP0001119_abnormal_female_reproductive1.15262233
75MP0005220_abnormal_exocrine_pancreas1.14670347
76MP0005389_reproductive_system_phenotype1.12368711
77MP0002161_abnormal_fertility/fecundity1.11914661
78MP0003705_abnormal_hypodermis_morpholog1.10841296
79MP0005253_abnormal_eye_physiology1.09256710
80MP0003699_abnormal_female_reproductive1.09121384
81MP0002653_abnormal_ependyma_morphology1.07918841
82MP0008932_abnormal_embryonic_tissue1.05605173
83MP0003937_abnormal_limbs/digits/tail_de1.04374675
84MP0002735_abnormal_chemical_nociception1.04349374
85MP0001324_abnormal_eye_pigmentation1.03477921
86MP0003183_abnormal_peptide_metabolism1.02099764
87MP0000427_abnormal_hair_cycle1.02068221
88MP0003950_abnormal_plasma_membrane1.02000467
89MP0001984_abnormal_olfaction1.00859404
90MP0003300_gastrointestinal_ulcer1.00325667
91MP0002136_abnormal_kidney_physiology0.99933571
92MP0000598_abnormal_liver_morphology0.98672992
93MP0005645_abnormal_hypothalamus_physiol0.97873763
94MP0002822_catalepsy0.97518695
95MP0006072_abnormal_retinal_apoptosis0.97496412
96MP0001529_abnormal_vocalization0.96521918
97MP0008789_abnormal_olfactory_epithelium0.93469056
98MP0001501_abnormal_sleep_pattern0.93325144
99MP0001293_anophthalmia0.92717933
100MP0002876_abnormal_thyroid_physiology0.92494043
101MP0003880_abnormal_central_pattern0.92423756
102MP0005058_abnormal_lysosome_morphology0.91639761
103MP0004782_abnormal_surfactant_physiolog0.91229295
104MP0003941_abnormal_skin_development0.89863114
105MP0000631_abnormal_neuroendocrine_gland0.89678949
106MP0000647_abnormal_sebaceous_gland0.89282892
107MP0005408_hypopigmentation0.88759793
108MP0004036_abnormal_muscle_relaxation0.88148418
109MP0003786_premature_aging0.87388932
110MP0009642_abnormal_blood_homeostasis0.86645672
111MP0005647_abnormal_sex_gland0.85926303
112MP0009764_decreased_sensitivity_to0.85479499
113MP0002084_abnormal_developmental_patter0.85404815
114MP0006054_spinal_hemorrhage0.83978307
115MP0003011_delayed_dark_adaptation0.83570128
116MP0009046_muscle_twitch0.81701929
117MP0009697_abnormal_copulation0.81139494
118MP0002078_abnormal_glucose_homeostasis0.80120554
119MP0001485_abnormal_pinna_reflex0.80111025
120MP0002254_reproductive_system_inflammat0.77128259
121MP0003283_abnormal_digestive_organ0.76876400
122MP0008469_abnormal_protein_level0.76397737
123MP0000538_abnormal_urinary_bladder0.76369514
124MP0002928_abnormal_bile_duct0.74935118
125MP0004233_abnormal_muscle_weight0.74585845
126MP0000462_abnormal_digestive_system0.74349555
127MP0003567_abnormal_fetal_cardiomyocyte0.74240693
128MP0002796_impaired_skin_barrier0.73822577
129MP0002163_abnormal_gland_morphology0.73432536
130MP0003119_abnormal_digestive_system0.72625795
131MP0001486_abnormal_startle_reflex0.72483238
132MP0004142_abnormal_muscle_tone0.72420222
133MP0006036_abnormal_mitochondrial_physio0.72323305
134MP0002736_abnormal_nociception_after0.71875726
135MP0003656_abnormal_erythrocyte_physiolo0.70293170
136MP0002090_abnormal_vision0.70026815
137MP0009765_abnormal_xenobiotic_induced0.69948498
138MP0005167_abnormal_blood-brain_barrier0.69874879
139MP0009745_abnormal_behavioral_response0.69495098
140MP0009763_increased_sensitivity_to0.68630034
141MP0000604_amyloidosis0.68174697
142MP0005380_embryogenesis_phenotype0.68168048
143MP0001672_abnormal_embryogenesis/_devel0.68168048
144MP0005670_abnormal_white_adipose0.67940689
145MP0001664_abnormal_digestion0.67243375
146MP0001873_stomach_inflammation0.66850373
147MP0001730_embryonic_growth_arrest0.66263516
148MP0005376_homeostasis/metabolism_phenot0.65738998
149MP0008004_abnormal_stomach_pH0.65080912
150MP0004133_heterotaxia0.63893048
151MP0008007_abnormal_cellular_replicative0.63749843
152MP0003638_abnormal_response/metabolism_0.63424214
153MP0003878_abnormal_ear_physiology0.61332055
154MP0005377_hearing/vestibular/ear_phenot0.61332055
155MP0003724_increased_susceptibility_to0.59763848
156MP0001663_abnormal_digestive_system0.58851434
157MP0005381_digestive/alimentary_phenotyp0.58166030
158MP0001944_abnormal_pancreas_morphology0.57794055
159MP0005448_abnormal_energy_balance0.56890867
160MP0005334_abnormal_fat_pad0.56797617
161MP0001661_extended_life_span0.56564968
162MP0009053_abnormal_anal_canal0.54913518
163MP0005535_abnormal_body_temperature0.54807003
164MP0000230_abnormal_systemic_arterial0.54784006
165MP0003953_abnormal_hormone_level0.53170461
166MP0005666_abnormal_adipose_tissue0.52621533
167MP0010368_abnormal_lymphatic_system0.51957003
168MP0005266_abnormal_metabolism0.50221695
169MP0009384_cardiac_valve_regurgitation0.50214344
170MP0010155_abnormal_intestine_physiology0.50190841
171MP0002971_abnormal_brown_adipose0.50159005
172MP0008873_increased_physiological_sensi0.49871926
173MP0005166_decreased_susceptibility_to0.49649558
174MP0009780_abnormal_chondrocyte_physiolo0.49472812
175MP0000477_abnormal_intestine_morphology0.49238423
176MP0004130_abnormal_muscle_cell0.43421940
177MP0002135_abnormal_kidney_morphology0.42249771
178MP0008872_abnormal_physiological_respon0.42099863
179MP0001881_abnormal_mammary_gland0.40861123
180MP0002060_abnormal_skin_morphology0.39896418
181MP0003866_abnormal_defecation0.39608576
182MP0006035_abnormal_mitochondrial_morpho0.39055823
183MP0005395_other_phenotype0.39039690
184MP0003959_abnormal_lean_body0.38539811
185MP0002098_abnormal_vibrissa_morphology0.38141613

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.36481415
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23604900
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.73199951
4Deep venous thrombosis (HP:0002625)5.43708539
5Hypobetalipoproteinemia (HP:0003563)5.24540201
6Xanthomatosis (HP:0000991)5.23257975
7Prolonged partial thromboplastin time (HP:0003645)4.67603990
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.66408597
9Hyperglycinuria (HP:0003108)4.24591144
10Gout (HP:0001997)4.20190588
11Hyperammonemia (HP:0001987)4.19426072
12Chromsome breakage (HP:0040012)4.19271007
13Hypoglycemic coma (HP:0001325)4.18709748
14Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18543065
15Hyperlipoproteinemia (HP:0010980)4.09782681
16Fat malabsorption (HP:0002630)4.05503557
17Ketosis (HP:0001946)4.05388581
18Hypolipoproteinemia (HP:0010981)3.98830917
19Complement deficiency (HP:0004431)3.89864853
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.89129387
21Tubulointerstitial nephritis (HP:0001970)3.86923485
22Abnormality of glycine metabolism (HP:0010895)3.84649785
23Abnormality of serine family amino acid metabolism (HP:0010894)3.84649785
24Hyperglycinemia (HP:0002154)3.83855379
25Abnormality of purine metabolism (HP:0004352)3.79245797
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78506956
27Conjugated hyperbilirubinemia (HP:0002908)3.76625523
28Abnormality of fatty-acid metabolism (HP:0004359)3.72572005
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.63343870
30Abnormality of the common coagulation pathway (HP:0010990)3.55050492
31Abnormality of nucleobase metabolism (HP:0010932)3.46745939
32Malnutrition (HP:0004395)3.45635509
33Ketoacidosis (HP:0001993)3.45110073
34Epidermoid cyst (HP:0200040)3.42584574
35Hypoalphalipoproteinemia (HP:0003233)3.41552196
36Joint hemorrhage (HP:0005261)3.39396302
37Abnormality of the intrinsic pathway (HP:0010989)3.33133273
38Gonadotropin excess (HP:0000837)3.16806739
39Hyperuricemia (HP:0002149)3.13784626
40Increased purine levels (HP:0004368)3.13784626
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13498513
42Generalized aminoaciduria (HP:0002909)3.10441657
43Abnormality of methionine metabolism (HP:0010901)3.07848714
44Alkalosis (HP:0001948)3.04248675
45Pancreatic fibrosis (HP:0100732)2.99784998
46Proximal tubulopathy (HP:0000114)2.97448873
47Colon cancer (HP:0003003)2.97244598
48Pancreatic cysts (HP:0001737)2.93974830
49Horizontal nystagmus (HP:0000666)2.93289253
50Central scotoma (HP:0000603)2.91734172
51Metabolic acidosis (HP:0001942)2.90212310
52Steatorrhea (HP:0002570)2.88477858
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88308643
54Dicarboxylic aciduria (HP:0003215)2.88308643
55Hyperbilirubinemia (HP:0002904)2.87663597
56Hyperactive renin-angiotensin system (HP:0000841)2.86093684
57Scotoma (HP:0000575)2.85980042
58Hypercholesterolemia (HP:0003124)2.85743881
59Glycosuria (HP:0003076)2.85658155
60Abnormality of urine glucose concentration (HP:0011016)2.85658155
61Abnormality of pyrimidine metabolism (HP:0004353)2.81746224
62Gaze-evoked nystagmus (HP:0000640)2.81130894
63True hermaphroditism (HP:0010459)2.80910915
64Abnormality of complement system (HP:0005339)2.77415276
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.72725253
66Vascular calcification (HP:0004934)2.72346071
67Delayed CNS myelination (HP:0002188)2.71104975
68Hepatocellular carcinoma (HP:0001402)2.66778763
69Ectopic kidney (HP:0000086)2.66737847
70Hypoglycemic seizures (HP:0002173)2.66048360
71Abnormal lung lobation (HP:0002101)2.65373521
72Lethargy (HP:0001254)2.65185179
73Carpal bone hypoplasia (HP:0001498)2.63183597
74Sensorimotor neuropathy (HP:0007141)2.62983231
75Median cleft lip (HP:0000161)2.61194692
76Supernumerary spleens (HP:0009799)2.60058439
77Volvulus (HP:0002580)2.59547545
78Abnormality of chromosome stability (HP:0003220)2.58284092
79Metabolic alkalosis (HP:0200114)2.57784748
80Genetic anticipation (HP:0003743)2.54447358
81Abnormal biliary tract physiology (HP:0012439)2.52166316
82Bile duct proliferation (HP:0001408)2.52166316
83Hydroxyprolinuria (HP:0003080)2.51486311
84Abnormality of proline metabolism (HP:0010907)2.51486311
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.48945964
86Late onset (HP:0003584)2.47113228
87Abnormality of the renal collecting system (HP:0004742)2.46993743
88Abnormality of serum amino acid levels (HP:0003112)2.45799044
89Type I transferrin isoform profile (HP:0003642)2.45069733
90Chronic hepatic failure (HP:0100626)2.45036600
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.43320123
92Rhabdomyosarcoma (HP:0002859)2.39578542
93Cardiovascular calcification (HP:0011915)2.39418322
94Nephronophthisis (HP:0000090)2.36513955
95Esophageal varix (HP:0002040)2.35153797
96Duplicated collecting system (HP:0000081)2.34801542
97Cystic liver disease (HP:0006706)2.34538452
98Acanthocytosis (HP:0001927)2.33996497
99Abnormality of the labia minora (HP:0012880)2.32906461
100Progressive cerebellar ataxia (HP:0002073)2.31776974
101Irritability (HP:0000737)2.29402517
102Vomiting (HP:0002013)2.28767335
103Symptomatic seizures (HP:0011145)2.28436373
104Abnormality of the renal medulla (HP:0100957)2.28308748
105Rickets (HP:0002748)2.27350727
106Nephroblastoma (Wilms tumor) (HP:0002667)2.27150616
107Abnormality of chloride homeostasis (HP:0011422)2.26559394
108Pancreatitis (HP:0001733)2.26501273
109Ileus (HP:0002595)2.25492081
110Abnormality of alanine metabolism (HP:0010916)2.25209775
111Hyperalaninemia (HP:0003348)2.25209775
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25209775
113Spontaneous abortion (HP:0005268)2.24339271
114Cerebral edema (HP:0002181)2.24061141
115Duodenal stenosis (HP:0100867)2.23055873
116Small intestinal stenosis (HP:0012848)2.23055873
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21358158
118Abnormal protein N-linked glycosylation (HP:0012347)2.21358158
119Abnormal protein glycosylation (HP:0012346)2.21358158
120Abnormal glycosylation (HP:0012345)2.21358158
121Azoospermia (HP:0000027)2.21227260
122Abnormality of midbrain morphology (HP:0002418)2.20902531
123Molar tooth sign on MRI (HP:0002419)2.20902531
124Sloping forehead (HP:0000340)2.20332763
125Hyperinsulinemic hypoglycemia (HP:0000825)2.20310336
126Type II lissencephaly (HP:0007260)2.20236152
127Abnormal enzyme/coenzyme activity (HP:0012379)2.16186466
128Skin nodule (HP:0200036)2.16128561
129Spastic diplegia (HP:0001264)2.15697947
130Hypokalemic alkalosis (HP:0001949)2.15694730
131Enlarged kidneys (HP:0000105)2.13607612
132Embryonal renal neoplasm (HP:0011794)2.12683578
133Meckel diverticulum (HP:0002245)2.11466798
134Preaxial hand polydactyly (HP:0001177)2.09002133
135Sclerocornea (HP:0000647)2.08506822
136Myocardial infarction (HP:0001658)2.08172546
137Abnormal gallbladder physiology (HP:0012438)2.06997637
138Cholecystitis (HP:0001082)2.06997637
139Abnormality of the ileum (HP:0001549)2.05488457
140Small hand (HP:0200055)2.04861947
141Short tibia (HP:0005736)2.04393450
142Right ventricular cardiomyopathy (HP:0011663)2.02088104
143Abnormality of vitamin metabolism (HP:0100508)2.00482313
144Hyperphosphaturia (HP:0003109)1.99751591
145Ependymoma (HP:0002888)1.99705534
146Hyperglycemia (HP:0003074)1.99073323
147Microvesicular hepatic steatosis (HP:0001414)1.98993923
148Abnormality of alkaline phosphatase activity (HP:0004379)1.97892470
149Nephrolithiasis (HP:0000787)1.97840578
150Abnormal cartilage morphology (HP:0002763)1.97417074
151Abnormal gallbladder morphology (HP:0012437)1.96122467
152Neonatal onset (HP:0003623)1.95634522
153Astigmatism (HP:0000483)1.95227422
154Congenital stationary night blindness (HP:0007642)1.93850056
155Postaxial foot polydactyly (HP:0001830)1.93849834
156Anencephaly (HP:0002323)1.93005764
157Congenital hepatic fibrosis (HP:0002612)1.92970572
158Systemic lupus erythematosus (HP:0002725)1.92239733
159Cerebellar dysplasia (HP:0007033)1.92168394
160Renal cortical cysts (HP:0000803)1.91075221
161Abnormality of the duodenum (HP:0002246)1.90995540
162Abdominal distention (HP:0003270)1.89726184
163Attenuation of retinal blood vessels (HP:0007843)1.86929040
164Medial flaring of the eyebrow (HP:0010747)1.86602385
165Retinal dysplasia (HP:0007973)1.86518314
166Abnormality of the nasal septum (HP:0000419)1.86305379
167Abnormality of DNA repair (HP:0003254)1.86061612
168Nausea (HP:0002018)1.86006407
169Cholelithiasis (HP:0001081)1.84358751
170Astrocytoma (HP:0009592)1.84328833
171Abnormality of the astrocytes (HP:0100707)1.84328833
172Elevated alkaline phosphatase (HP:0003155)1.81225840
173Glomerulosclerosis (HP:0000096)1.81059763
174Bicornuate uterus (HP:0000813)1.80582379
175Dynein arm defect of respiratory motile cilia (HP:0012255)1.79730247
176Absent/shortened dynein arms (HP:0200106)1.79730247
177Abnormal spermatogenesis (HP:0008669)1.79352778
178Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78466619
179Absent radius (HP:0003974)1.78102364
180Glioma (HP:0009733)1.77857240
181Birth length less than 3rd percentile (HP:0003561)1.77410423
182Degeneration of the lateral corticospinal tracts (HP:0002314)1.76291381
183Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76291381
184Male pseudohermaphroditism (HP:0000037)1.75280718
185Abnormality of the preputium (HP:0100587)1.74404314
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.74294339
187Bifid tongue (HP:0010297)1.73698209
188Hip dysplasia (HP:0001385)1.73003350
189Tubulointerstitial abnormality (HP:0001969)1.71655207
190Genital tract atresia (HP:0001827)1.70676604
191Acute encephalopathy (HP:0006846)1.66289166
192Abnormal ciliary motility (HP:0012262)1.65260248
193Reticulocytopenia (HP:0001896)1.64503738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.65073600
2BCKDK5.07857139
3FRK4.53314354
4PNCK4.08500636
5ERN14.02195576
6ACVR1B3.03981856
7TTK2.86251052
8TAOK32.78509513
9WNK42.54425550
10FGFR42.53765415
11SIK12.46540357
12MAP3K22.46101778
13PIK3CA2.45503645
14INSRR2.36803883
15MET2.32191012
16CDK192.28716534
17WNK32.27999960
18CDC72.23719283
19LATS12.09845650
20MAP2K21.99260950
21ERBB41.97398100
22PLK41.88549230
23BMPR1B1.88153980
24MAP4K21.80257729
25PBK1.77983015
26PTK61.75754908
27OXSR11.75241917
28TAF11.72393588
29EPHA21.70684388
30CAMK1G1.69856519
31ZAK1.61718407
32MAPK151.60543479
33PIK3CG1.56181259
34NEK11.55836413
35MUSK1.52920430
36WEE11.52505140
37EIF2AK31.46932101
38TSSK61.41892057
39NTRK31.38055195
40PTK2B1.36695868
41MST41.36058396
42KSR21.33649665
43PLK11.31792242
44PKN21.28783459
45NUAK11.28743309
46MKNK21.23930618
47MAP3K41.22970712
48LMTK21.20843544
49STK38L1.19228778
50PLK21.18317155
51TNIK1.17881937
52RIPK11.16289676
53CLK11.12311897
54PTK21.10941858
55CHEK21.09916410
56TRIB31.09619543
57EPHB11.09150461
58ATR1.08634812
59MAP2K11.08266789
60MAPK111.07506202
61BRSK21.06397924
62NME11.05317524
63STK391.04846286
64PLK31.03587826
65MAP3K31.00394043
66FLT30.98658247
67MAP3K70.97649199
68TYK20.96578388
69NEK90.95503809
70NEK60.94704775
71NEK20.91872041
72MAP3K140.89433566
73GRK60.89233875
74SRPK10.88373209
75AKT30.86548496
76MAP2K60.85202136
77PRKG20.83303595
78ATM0.83179136
79ERBB20.81779553
80CDK120.81606006
81ABL20.80388500
82FGFR20.78076947
83PRKAA20.76472619
84JAK20.75741887
85MAP3K10.75664396
86MYLK0.74845464
87MKNK10.74723976
88ADRBK20.74618798
89FGR0.72214310
90CDK30.71544390
91CHEK10.71165434
92NLK0.70975708
93TBK10.69827928
94STK380.69088736
95PINK10.68565305
96VRK10.67956217
97FER0.67894357
98KDR0.66850180
99BUB10.66189975
100EIF2AK10.65834220
101EPHA40.62753246
102STK240.62570182
103IRAK30.62377295
104MAP2K40.62321845
105BRD40.61712489
106TRIM280.61352472
107DYRK1B0.61249533
108GSK3A0.60624903
109STK40.59848755
110WNK10.59543823
111CSK0.55448153
112ADRBK10.53828531
113TIE10.52877668
114PRKCZ0.51858879
115MAP3K100.51035631
116LRRK20.50832589
117DAPK20.49102546
118SGK10.48381284
119PRKAA10.47699101
120GRK10.47178649
121OBSCN0.46823808
122EPHA30.46535933
123JAK10.45475594
124RET0.45055726
125CAMK10.44796786
126CAMK2G0.44354735
127PRKCE0.43996133
128TGFBR20.43801388
129CSNK1G10.42916310
130CDK10.42748017
131DYRK1A0.41096685
132PAK30.40775883
133MAP3K110.40116064
134PRKACG0.39694176
135PRKACB0.38477714
136DYRK30.37894568
137BRSK10.37769062
138BMX0.37633422
139PRKCG0.36782365
140SGK30.36277928
141EPHB20.35851873
142AURKB0.35762397
143SGK4940.35750133
144SGK2230.35750133
145PDK40.35457246
146PDK30.35457246
147CDK60.34813603
148PRKCQ0.34776383
149MAP2K30.34656472
150CDK40.34632599
151CDK20.33635490
152IGF1R0.32959192
153RAF10.32671968
154PRKCI0.32468791
155AKT20.32224965
156SGK20.31983616
157MAP3K80.31802924
158CSNK1G20.31715920
159PDPK10.31316010
160TGFBR10.31237598
161PDK20.30827718
162CAMK1D0.30463138
163TESK20.30448671
164CSNK1D0.30251726
165CSNK1A1L0.30136417
166CSNK1E0.30127688
167PRKCA0.28814322
168IKBKE0.27870901
169STK30.25003383
170EGFR0.23878548
171PAK40.23323607
172FGFR30.22982385
173CDK90.22339501
174MAPK40.21639336
175TESK10.21586431

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62746108
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44101820
3Homologous recombination_Homo sapiens_hsa034403.13887630
4Nitrogen metabolism_Homo sapiens_hsa009102.96907573
5Non-homologous end-joining_Homo sapiens_hsa034502.74879434
6Sulfur metabolism_Homo sapiens_hsa009202.67674813
7Tryptophan metabolism_Homo sapiens_hsa003802.62101236
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60528476
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56858525
10Arginine biosynthesis_Homo sapiens_hsa002202.55540470
11Fanconi anemia pathway_Homo sapiens_hsa034602.53188801
12Fatty acid degradation_Homo sapiens_hsa000712.51032304
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49243547
14Basal transcription factors_Homo sapiens_hsa030222.49169999
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46009850
16Butanoate metabolism_Homo sapiens_hsa006502.42236745
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38026105
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20303949
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20224883
20Mismatch repair_Homo sapiens_hsa034302.19852696
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16292695
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14033256
23Peroxisome_Homo sapiens_hsa041462.01797200
24Base excision repair_Homo sapiens_hsa034102.00034854
25Complement and coagulation cascades_Homo sapiens_hsa046101.99906487
26Propanoate metabolism_Homo sapiens_hsa006401.96078433
27Chemical carcinogenesis_Homo sapiens_hsa052041.95380407
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92826632
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.89052447
30Fat digestion and absorption_Homo sapiens_hsa049751.87112567
31Histidine metabolism_Homo sapiens_hsa003401.86289836
32PPAR signaling pathway_Homo sapiens_hsa033201.85120333
33RNA transport_Homo sapiens_hsa030131.82980774
34Bile secretion_Homo sapiens_hsa049761.81335416
35RNA degradation_Homo sapiens_hsa030181.75254579
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.72363278
37DNA replication_Homo sapiens_hsa030301.68336571
38RNA polymerase_Homo sapiens_hsa030201.67618083
39Fatty acid metabolism_Homo sapiens_hsa012121.66976874
40Caffeine metabolism_Homo sapiens_hsa002321.65414783
41Selenocompound metabolism_Homo sapiens_hsa004501.62598706
42beta-Alanine metabolism_Homo sapiens_hsa004101.61289123
43Cell cycle_Homo sapiens_hsa041101.58220748
44Retinol metabolism_Homo sapiens_hsa008301.53849388
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.51828714
46Starch and sucrose metabolism_Homo sapiens_hsa005001.49715754
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49391078
48Folate biosynthesis_Homo sapiens_hsa007901.47297140
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45860981
50Pyruvate metabolism_Homo sapiens_hsa006201.43512904
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41873162
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40668673
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40408713
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.37417321
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35894519
56Vitamin digestion and absorption_Homo sapiens_hsa049771.34269338
57Phenylalanine metabolism_Homo sapiens_hsa003601.33376129
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33193940
59Phototransduction_Homo sapiens_hsa047441.29921325
60Nicotine addiction_Homo sapiens_hsa050331.25177264
61Dorso-ventral axis formation_Homo sapiens_hsa043201.20286420
62Nucleotide excision repair_Homo sapiens_hsa034201.19909537
63Carbon metabolism_Homo sapiens_hsa012001.19834804
64Tyrosine metabolism_Homo sapiens_hsa003501.18703226
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14048476
66ABC transporters_Homo sapiens_hsa020101.12537129
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08725695
68Fatty acid elongation_Homo sapiens_hsa000621.08594539
69Olfactory transduction_Homo sapiens_hsa047401.08423195
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.07464678
71Glutathione metabolism_Homo sapiens_hsa004801.07380634
72Taste transduction_Homo sapiens_hsa047421.07000840
73Oocyte meiosis_Homo sapiens_hsa041141.06783584
74Staphylococcus aureus infection_Homo sapiens_hsa051501.05894647
75Sulfur relay system_Homo sapiens_hsa041221.04706602
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03802282
77Arginine and proline metabolism_Homo sapiens_hsa003301.01220834
78N-Glycan biosynthesis_Homo sapiens_hsa005100.99887864
79Regulation of autophagy_Homo sapiens_hsa041400.99343350
80Biosynthesis of amino acids_Homo sapiens_hsa012300.97440174
81Steroid biosynthesis_Homo sapiens_hsa001000.94819497
82Huntingtons disease_Homo sapiens_hsa050160.93939056
83Glycerolipid metabolism_Homo sapiens_hsa005610.93579910
84Purine metabolism_Homo sapiens_hsa002300.93119060
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92024078
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91773063
87Circadian rhythm_Homo sapiens_hsa047100.89868321
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84922669
89Pyrimidine metabolism_Homo sapiens_hsa002400.84226893
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82310892
91mRNA surveillance pathway_Homo sapiens_hsa030150.81162974
92Mineral absorption_Homo sapiens_hsa049780.79930077
93Sphingolipid metabolism_Homo sapiens_hsa006000.77495197
94Pentose phosphate pathway_Homo sapiens_hsa000300.77393194
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76915033
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76775872
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74524519
98Fructose and mannose metabolism_Homo sapiens_hsa000510.71695113
99Lysine degradation_Homo sapiens_hsa003100.68928003
100Parkinsons disease_Homo sapiens_hsa050120.63695627
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60611453
102Galactose metabolism_Homo sapiens_hsa000520.59656343
103Ovarian steroidogenesis_Homo sapiens_hsa049130.59125282
104TGF-beta signaling pathway_Homo sapiens_hsa043500.56355503
105Proteasome_Homo sapiens_hsa030500.54961769
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54300057
107Calcium signaling pathway_Homo sapiens_hsa040200.53503973
108Metabolic pathways_Homo sapiens_hsa011000.51129706
109Renin-angiotensin system_Homo sapiens_hsa046140.49665271
110Linoleic acid metabolism_Homo sapiens_hsa005910.49081507
111Spliceosome_Homo sapiens_hsa030400.48879459
112GABAergic synapse_Homo sapiens_hsa047270.40029061
113Protein digestion and absorption_Homo sapiens_hsa049740.37753874
114Vitamin B6 metabolism_Homo sapiens_hsa007500.36129885
115One carbon pool by folate_Homo sapiens_hsa006700.34888761
116p53 signaling pathway_Homo sapiens_hsa041150.34309916
117Fatty acid biosynthesis_Homo sapiens_hsa000610.30956041
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29281498
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23470231
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.22963196
121Insulin resistance_Homo sapiens_hsa049310.18821956
122Prion diseases_Homo sapiens_hsa050200.18277637
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17381406
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16807378
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15825912
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15755255
127Thyroid hormone synthesis_Homo sapiens_hsa049180.15152238
128Arachidonic acid metabolism_Homo sapiens_hsa005900.13428382
129Pancreatic secretion_Homo sapiens_hsa049720.11167722
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.10695779
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10200863
132Protein export_Homo sapiens_hsa030600.09145451
133Bladder cancer_Homo sapiens_hsa052190.05213190
134Other glycan degradation_Homo sapiens_hsa005110.03770799
135Hepatitis C_Homo sapiens_hsa051600.00135903
136Thyroid cancer_Homo sapiens_hsa05216-0.1070077
137Ether lipid metabolism_Homo sapiens_hsa00565-0.0962700
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0699630
139Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0514260
140Glucagon signaling pathway_Homo sapiens_hsa04922-0.0328893
141AMPK signaling pathway_Homo sapiens_hsa04152-0.0262432
142Oxidative phosphorylation_Homo sapiens_hsa00190-0.0086555

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