

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | response to peptidoglycan (GO:0032494) | 6.70359496 |
| 2 | neutrophil activation involved in immune response (GO:0002283) | 6.52622162 |
| 3 | neutrophil mediated immunity (GO:0002446) | 6.41969282 |
| 4 | respiratory burst (GO:0045730) | 6.14323891 |
| 5 | leukocyte aggregation (GO:0070486) | 5.71907653 |
| 6 | reactive oxygen species biosynthetic process (GO:1903409) | 5.69498182 |
| 7 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 5.68057740 |
| 8 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.45205110 |
| 9 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.45205110 |
| 10 | modulation by symbiont of host immune response (GO:0052553) | 5.45205110 |
| 11 | positive regulation by symbiont of host defense response (GO:0052509) | 5.45205110 |
| 12 | modulation by symbiont of host defense response (GO:0052031) | 5.45205110 |
| 13 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.45205110 |
| 14 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.37774482 |
| 15 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 5.22663161 |
| 16 | regulation of growth of symbiont in host (GO:0044126) | 5.22663161 |
| 17 | negative regulation of growth of symbiont in host (GO:0044130) | 5.22663161 |
| 18 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 5.22663161 |
| 19 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.15394350 |
| 20 | negative regulation of cell killing (GO:0031342) | 5.15394350 |
| 21 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 5.03012806 |
| 22 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 5.03012806 |
| 23 | myeloid leukocyte mediated immunity (GO:0002444) | 4.96068682 |
| 24 | hydrogen peroxide biosynthetic process (GO:0050665) | 4.94091112 |
| 25 | regulation of chemokine biosynthetic process (GO:0045073) | 4.91880622 |
| 26 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.80529442 |
| 27 | superoxide anion generation (GO:0042554) | 4.80107992 |
| 28 | granulocyte activation (GO:0036230) | 4.55887275 |
| 29 | macrophage activation involved in immune response (GO:0002281) | 4.48826807 |
| 30 | response to fungus (GO:0009620) | 4.47393947 |
| 31 | neutrophil activation (GO:0042119) | 4.47268969 |
| 32 | immunoglobulin mediated immune response (GO:0016064) | 4.44682826 |
| 33 | detection of bacterium (GO:0016045) | 4.43726639 |
| 34 | leukocyte mediated cytotoxicity (GO:0001909) | 4.42182171 |
| 35 | positive regulation of chemokine biosynthetic process (GO:0045080) | 4.24814630 |
| 36 | cellular response to zinc ion (GO:0071294) | 4.17297071 |
| 37 | positive regulation of mast cell activation (GO:0033005) | 4.17036326 |
| 38 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 4.16285612 |
| 39 | detection of biotic stimulus (GO:0009595) | 4.11274357 |
| 40 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.06062717 |
| 41 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.99344870 |
| 42 | myeloid cell activation involved in immune response (GO:0002275) | 3.98167844 |
| 43 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.95956502 |
| 44 | positive regulation of mast cell degranulation (GO:0043306) | 3.95956502 |
| 45 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.91643786 |
| 46 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.91358709 |
| 47 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.89825961 |
| 48 | response to host immune response (GO:0052572) | 3.89825961 |
| 49 | regulation of gamma-delta T cell activation (GO:0046643) | 3.88026582 |
| 50 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.83614976 |
| 51 | regulation of mast cell activation (GO:0033003) | 3.80981877 |
| 52 | defense response to fungus (GO:0050832) | 3.75826347 |
| 53 | regulation of mast cell degranulation (GO:0043304) | 3.72502035 |
| 54 | disruption of cells of other organism (GO:0044364) | 3.71862746 |
| 55 | killing of cells of other organism (GO:0031640) | 3.71862746 |
| 56 | positive regulation of interferon-alpha production (GO:0032727) | 3.70983492 |
| 57 | cellular extravasation (GO:0045123) | 3.68975309 |
| 58 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.61039338 |
| 59 | regulation of interferon-alpha production (GO:0032647) | 3.52736738 |
| 60 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.49349792 |
| 61 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.48813891 |
| 62 | neutrophil chemotaxis (GO:0030593) | 3.48268553 |
| 63 | defense response to protozoan (GO:0042832) | 3.47987345 |
| 64 | T-helper 1 type immune response (GO:0042088) | 3.46595717 |
| 65 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.46360432 |
| 66 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.46185738 |
| 67 | response to host (GO:0075136) | 3.46185738 |
| 68 | response to host defenses (GO:0052200) | 3.46185738 |
| 69 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.45991162 |
| 70 | response to muramyl dipeptide (GO:0032495) | 3.45186020 |
| 71 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.44185216 |
| 72 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.43148205 |
| 73 | sequestering of metal ion (GO:0051238) | 3.42772925 |
| 74 | negative regulation of interleukin-12 production (GO:0032695) | 3.41510057 |
| 75 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.40609184 |
| 76 | neutrophil migration (GO:1990266) | 3.38565975 |
| 77 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.35545093 |
| 78 | negative regulation of phagocytosis (GO:0050765) | 3.34024619 |
| 79 | macrophage activation (GO:0042116) | 3.31880396 |
| 80 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.29933372 |
| 81 | phagosome maturation (GO:0090382) | 3.29843331 |
| 82 | cell killing (GO:0001906) | 3.29774000 |
| 83 | regulation of leukocyte degranulation (GO:0043300) | 3.29660432 |
| 84 | detection of molecule of bacterial origin (GO:0032490) | 3.29337466 |
| 85 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.29056917 |
| 86 | B cell mediated immunity (GO:0019724) | 3.27693720 |
| 87 | negative regulation of mast cell activation (GO:0033004) | 3.27035480 |
| 88 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.26966542 |
| 89 | negative regulation of T cell mediated immunity (GO:0002710) | 3.26653748 |
| 90 | positive regulation of heat generation (GO:0031652) | 3.26133923 |
| 91 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.25334416 |
| 92 | detection of other organism (GO:0098543) | 3.24291392 |
| 93 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.23377501 |
| 94 | leukotriene metabolic process (GO:0006691) | 3.23089653 |
| 95 | microglial cell activation (GO:0001774) | 3.22599454 |
| 96 | leukocyte degranulation (GO:0043299) | 3.21946097 |
| 97 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.20519093 |
| 98 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.17913666 |
| 99 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.15550573 |
| 100 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.15106774 |
| 101 | regulation of tolerance induction (GO:0002643) | 3.14256528 |
| 102 | regulation of fever generation (GO:0031620) | 3.13988256 |
| 103 | regulation of hypersensitivity (GO:0002883) | 3.12972630 |
| 104 | response to protozoan (GO:0001562) | 3.10439341 |
| 105 | regulation of T cell tolerance induction (GO:0002664) | 3.10400772 |
| 106 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.08895761 |
| 107 | natural killer cell mediated immunity (GO:0002228) | 3.08895761 |
| 108 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.07622113 |
| 109 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.06095464 |
| 110 | lymphocyte chemotaxis (GO:0048247) | 3.03783429 |
| 111 | granulocyte chemotaxis (GO:0071621) | 3.03742633 |
| 112 | type I interferon signaling pathway (GO:0060337) | 3.03305422 |
| 113 | cellular response to type I interferon (GO:0071357) | 3.03305422 |
| 114 | regulation of antigen processing and presentation (GO:0002577) | 3.02839557 |
| 115 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.01213626 |
| 116 | response to type I interferon (GO:0034340) | 3.01033253 |
| 117 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.00904086 |
| 118 | positive regulation of leukocyte degranulation (GO:0043302) | 2.98719372 |
| 119 | detection of external biotic stimulus (GO:0098581) | 2.96629578 |
| 120 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.96176610 |
| 121 | positive regulation of antigen processing and presentation (GO:0002579) | 2.95937774 |
| 122 | myeloid leukocyte activation (GO:0002274) | 2.95812029 |
| 123 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.95728024 |
| 124 | granulocyte migration (GO:0097530) | 2.94659298 |
| 125 | leukocyte mediated immunity (GO:0002443) | 2.92525407 |
| 126 | positive regulation of interferon-beta production (GO:0032728) | 2.92344489 |
| 127 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.87994249 |
| 128 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.85967322 |
| 129 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.85624580 |
| 130 | mast cell activation (GO:0045576) | 2.84467743 |
| 131 | positive regulation of type 2 immune response (GO:0002830) | 2.83491816 |
| 132 | response to interleukin-15 (GO:0070672) | 2.82877102 |
| 133 | cellular response to interferon-gamma (GO:0071346) | 2.82804793 |
| 134 | germinal center formation (GO:0002467) | 2.82689493 |
| 135 | dendritic cell migration (GO:0036336) | 2.82422739 |
| 136 | B cell receptor signaling pathway (GO:0050853) | 2.82196121 |
| 137 | dendritic cell chemotaxis (GO:0002407) | 2.82159241 |
| 138 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.79918501 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.88681894 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 6.78333117 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.64128640 |
| 4 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.36737884 |
| 5 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.26422692 |
| 6 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 4.13894288 |
| 7 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.90693029 |
| 8 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.82677367 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.78087926 |
| 10 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.68067008 |
| 11 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.29206024 |
| 12 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.27485593 |
| 13 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.26639984 |
| 14 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.96984552 |
| 15 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.90523719 |
| 16 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.85145418 |
| 17 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.75896649 |
| 18 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.65215122 |
| 19 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.52257195 |
| 20 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.48534729 |
| 21 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.43270228 |
| 22 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.36292667 |
| 23 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.16271651 |
| 24 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.07687188 |
| 25 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.07253408 |
| 26 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.07221391 |
| 27 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.97387201 |
| 28 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.96973963 |
| 29 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.95153096 |
| 30 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.91856034 |
| 31 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.83660416 |
| 32 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.83189458 |
| 33 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77110919 |
| 34 | * MYB_26560356_Chip-Seq_TH2_Human | 1.74681179 |
| 35 | SPI1_23127762_ChIP-Seq_K562_Human | 1.72622743 |
| 36 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70821399 |
| 37 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.69070749 |
| 38 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.68641529 |
| 39 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.54071627 |
| 40 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.53184313 |
| 41 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.51964991 |
| 42 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.50895049 |
| 43 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.50009776 |
| 44 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.47465960 |
| 45 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.46387273 |
| 46 | MAF_26560356_Chip-Seq_TH1_Human | 1.44393623 |
| 47 | MYB_26560356_Chip-Seq_TH1_Human | 1.42863063 |
| 48 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.42327276 |
| 49 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.40654271 |
| 50 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.36071881 |
| 51 | * SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.35372022 |
| 52 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.34229850 |
| 53 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29036304 |
| 54 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.28120218 |
| 55 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.26851964 |
| 56 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24452634 |
| 57 | GATA3_26560356_Chip-Seq_TH2_Human | 1.22126252 |
| 58 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.19712791 |
| 59 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.17930648 |
| 60 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.16510620 |
| 61 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.12111646 |
| 62 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.11509066 |
| 63 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.09622835 |
| 64 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.09092769 |
| 65 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.08225263 |
| 66 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.07902726 |
| 67 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.06847298 |
| 68 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.05888503 |
| 69 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.05268569 |
| 70 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.04798575 |
| 71 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.01365648 |
| 72 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.00886951 |
| 73 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.97163285 |
| 74 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.96496725 |
| 75 | GATA1_19941826_ChIP-Seq_K562_Human | 0.95660866 |
| 76 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.95457117 |
| 77 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94883342 |
| 78 | GATA1_22025678_ChIP-Seq_K562_Human | 0.92328205 |
| 79 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.91402331 |
| 80 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.91103377 |
| 81 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.91069901 |
| 82 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.89051456 |
| 83 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.87860949 |
| 84 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.86985149 |
| 85 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.86735791 |
| 86 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.85227452 |
| 87 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83270821 |
| 88 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82168430 |
| 89 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.81473460 |
| 90 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.81395897 |
| 91 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.78129250 |
| 92 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.76329506 |
| 93 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.73790242 |
| 94 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.73772350 |
| 95 | MYC_22102868_ChIP-Seq_BL_Human | 0.72015504 |
| 96 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.70973617 |
| 97 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.70191580 |
| 98 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.69904559 |
| 99 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.69837581 |
| 100 | MAF_26560356_Chip-Seq_TH2_Human | 0.69150974 |
| 101 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.66399489 |
| 102 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.65941499 |
| 103 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.65633374 |
| 104 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.64963724 |
| 105 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.64425081 |
| 106 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.63574387 |
| 107 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.63555098 |
| 108 | GATA3_26560356_Chip-Seq_TH1_Human | 0.63086102 |
| 109 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.62261651 |
| 110 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.61683357 |
| 111 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.61534868 |
| 112 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.60459486 |
| 113 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.58889708 |
| 114 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.58878734 |
| 115 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.58733714 |
| 116 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.57678693 |
| 117 | GATA2_19941826_ChIP-Seq_K562_Human | 0.56303097 |
| 118 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.53807082 |
| 119 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.53433434 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003436_decreased_susceptibility_to | 4.50038667 |
| 2 | MP0009785_altered_susceptibility_to | 4.39886620 |
| 3 | MP0001835_abnormal_antigen_presentation | 4.18684198 |
| 4 | MP0002419_abnormal_innate_immunity | 3.74924266 |
| 5 | MP0002148_abnormal_hypersensitivity_rea | 3.62710012 |
| 6 | MP0003303_peritoneal_inflammation | 3.45703132 |
| 7 | MP0005025_abnormal_response_to | 3.25239928 |
| 8 | MP0005000_abnormal_immune_tolerance | 3.22755157 |
| 9 | MP0003724_increased_susceptibility_to | 3.16241348 |
| 10 | MP0006082_CNS_inflammation | 2.63461071 |
| 11 | MP0005058_abnormal_lysosome_morphology | 2.62230211 |
| 12 | MP0002452_abnormal_antigen_presenting | 2.57412884 |
| 13 | MP0003172_abnormal_lysosome_physiology | 2.48009642 |
| 14 | MP0005464_abnormal_platelet_physiology | 2.41069610 |
| 15 | MP0002723_abnormal_immune_serum | 2.40765169 |
| 16 | MP0001533_abnormal_skeleton_physiology | 2.35581632 |
| 17 | MP0005387_immune_system_phenotype | 2.34709888 |
| 18 | MP0001790_abnormal_immune_system | 2.34709888 |
| 19 | MP0001800_abnormal_humoral_immune | 2.32745628 |
| 20 | MP0001819_abnormal_immune_cell | 2.29337818 |
| 21 | MP0002420_abnormal_adaptive_immunity | 2.28471589 |
| 22 | MP0005671_abnormal_response_to | 2.28082934 |
| 23 | MP0002006_tumorigenesis | 2.18597786 |
| 24 | MP0000685_abnormal_immune_system | 2.07090404 |
| 25 | MP0001845_abnormal_inflammatory_respons | 2.02749251 |
| 26 | MP0000343_altered_response_to | 2.01882674 |
| 27 | MP0009764_decreased_sensitivity_to | 2.01538448 |
| 28 | MP0001853_heart_inflammation | 1.97782613 |
| 29 | MP0003075_altered_response_to | 1.95887430 |
| 30 | MP0000858_altered_metastatic_potential | 1.91905776 |
| 31 | MP0003183_abnormal_peptide_metabolism | 1.89041821 |
| 32 | MP0002405_respiratory_system_inflammati | 1.88127399 |
| 33 | MP0003448_altered_tumor_morphology | 1.71010864 |
| 34 | MP0008469_abnormal_protein_level | 1.69399290 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.66449329 |
| 36 | MP0000569_abnormal_digit_pigmentation | 1.66045730 |
| 37 | MP0004947_skin_inflammation | 1.64974508 |
| 38 | MP0002166_altered_tumor_susceptibility | 1.64012072 |
| 39 | MP0009278_abnormal_bone_marrow | 1.63909037 |
| 40 | MP0005167_abnormal_blood-brain_barrier | 1.62232790 |
| 41 | MP0000716_abnormal_immune_system | 1.60922411 |
| 42 | MP0010155_abnormal_intestine_physiology | 1.60735736 |
| 43 | MP0001545_abnormal_hematopoietic_system | 1.50104362 |
| 44 | MP0005397_hematopoietic_system_phenotyp | 1.50104362 |
| 45 | MP0002398_abnormal_bone_marrow | 1.49582939 |
| 46 | MP0003191_abnormal_cellular_cholesterol | 1.47982750 |
| 47 | MP0003186_abnormal_redox_activity | 1.43995684 |
| 48 | MP0005174_abnormal_tail_pigmentation | 1.40886260 |
| 49 | MP0004510_myositis | 1.40121818 |
| 50 | MP0000604_amyloidosis | 1.34025744 |
| 51 | MP0005166_decreased_susceptibility_to | 1.33213365 |
| 52 | MP0002998_abnormal_bone_remodeling | 1.33057947 |
| 53 | MP0002429_abnormal_blood_cell | 1.32072299 |
| 54 | MP0004782_abnormal_surfactant_physiolog | 1.30406002 |
| 55 | MP0005164_abnormal_response_to | 1.27749709 |
| 56 | MP0000689_abnormal_spleen_morphology | 1.26333202 |
| 57 | MP0002396_abnormal_hematopoietic_system | 1.22875401 |
| 58 | MP0005451_abnormal_body_composition | 1.21932851 |
| 59 | MP0003806_abnormal_nucleotide_metabolis | 1.21001303 |
| 60 | MP0002722_abnormal_immune_system | 1.20485549 |
| 61 | MP0003656_abnormal_erythrocyte_physiolo | 1.18938703 |
| 62 | MP0003690_abnormal_glial_cell | 1.14784913 |
| 63 | MP0002132_abnormal_respiratory_system | 1.13136527 |
| 64 | MP0005310_abnormal_salivary_gland | 1.11132462 |
| 65 | MP0003300_gastrointestinal_ulcer | 1.10581898 |
| 66 | MP0009763_increased_sensitivity_to | 1.07886460 |
| 67 | MP0010307_abnormal_tumor_latency | 1.07752124 |
| 68 | MP0000490_abnormal_crypts_of | 1.07042206 |
| 69 | MP0003828_pulmonary_edema | 1.05121262 |
| 70 | MP0001851_eye_inflammation | 1.04562864 |
| 71 | MP0005390_skeleton_phenotype | 1.01496373 |
| 72 | MP0004381_abnormal_hair_follicle | 0.95349929 |
| 73 | MP0000465_gastrointestinal_hemorrhage | 0.93957902 |
| 74 | MP0008004_abnormal_stomach_pH | 0.93928073 |
| 75 | MP0002277_abnormal_respiratory_mucosa | 0.90408416 |
| 76 | MP0000015_abnormal_ear_pigmentation | 0.89432251 |
| 77 | MP0000249_abnormal_blood_vessel | 0.84702794 |
| 78 | MP0005076_abnormal_cell_differentiation | 0.82317507 |
| 79 | MP0004808_abnormal_hematopoietic_stem | 0.82092100 |
| 80 | MP0002933_joint_inflammation | 0.81281436 |
| 81 | MP0009840_abnormal_foam_cell | 0.80860871 |
| 82 | MP0008260_abnormal_autophagy | 0.77255281 |
| 83 | MP0003195_calcinosis | 0.76918991 |
| 84 | MP0005075_abnormal_melanosome_morpholog | 0.76659346 |
| 85 | MP0006054_spinal_hemorrhage | 0.73609835 |
| 86 | MP0004883_abnormal_blood_vessel | 0.73409061 |
| 87 | MP0000371_diluted_coat_color | 0.73190958 |
| 88 | MP0008057_abnormal_DNA_replication | 0.72137015 |
| 89 | MP0003763_abnormal_thymus_physiology | 0.71756113 |
| 90 | MP0008873_increased_physiological_sensi | 0.71191912 |
| 91 | MP0003566_abnormal_cell_adhesion | 0.69931819 |
| 92 | MP0009765_abnormal_xenobiotic_induced | 0.69090318 |
| 93 | MP0003329_amyloid_beta_deposits | 0.68380768 |
| 94 | MP0002332_abnormal_exercise_endurance | 0.66935066 |
| 95 | MP0003866_abnormal_defecation | 0.66258870 |
| 96 | MP0003795_abnormal_bone_structure | 0.65618920 |
| 97 | MP0001663_abnormal_digestive_system | 0.65398401 |
| 98 | MP0002019_abnormal_tumor_incidence | 0.64673372 |
| 99 | MP0003693_abnormal_embryo_hatching | 0.60964344 |
| 100 | MP0000920_abnormal_myelination | 0.60081001 |
| 101 | MP0003045_fibrosis | 0.59388061 |
| 102 | MP0000703_abnormal_thymus_morphology | 0.58896550 |
| 103 | MP0002139_abnormal_hepatobiliary_system | 0.58884905 |
| 104 | MP0008874_decreased_physiological_sensi | 0.58845935 |
| 105 | MP0002138_abnormal_hepatobiliary_system | 0.55533889 |
| 106 | MP0002254_reproductive_system_inflammat | 0.55051191 |
| 107 | MP0004130_abnormal_muscle_cell | 0.54596121 |
| 108 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.52811368 |
| 109 | MP0001986_abnormal_taste_sensitivity | 0.52801396 |
| 110 | MP0005319_abnormal_enzyme/_coenzyme | 0.52699925 |
| 111 | MP0003646_muscle_fatigue | 0.52253144 |
| 112 | MP0005165_increased_susceptibility_to | 0.49602275 |
| 113 | MP0002693_abnormal_pancreas_physiology | 0.49364201 |
| 114 | MP0010352_gastrointestinal_tract_polyps | 0.48809134 |
| 115 | MP0000609_abnormal_liver_physiology | 0.48662695 |
| 116 | MP0005023_abnormal_wound_healing | 0.48123798 |
| 117 | MP0002136_abnormal_kidney_physiology | 0.47733923 |
| 118 | MP0001873_stomach_inflammation | 0.46518657 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 8.48396429 |
| 2 | Eczematoid dermatitis (HP:0000976) | 7.83826796 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 7.74050361 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 6.92464094 |
| 5 | Mediastinal lymphadenopathy (HP:0100721) | 5.53058059 |
| 6 | Chronic obstructive pulmonary disease (HP:0006510) | 5.28286971 |
| 7 | Obstructive lung disease (HP:0006536) | 5.28286971 |
| 8 | Abnormality of macrophages (HP:0004311) | 5.21865313 |
| 9 | Gingivitis (HP:0000230) | 4.79611050 |
| 10 | Recurrent skin infections (HP:0001581) | 4.54496165 |
| 11 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.44414892 |
| 12 | Stomatitis (HP:0010280) | 4.34188007 |
| 13 | Autoimmune thrombocytopenia (HP:0001973) | 4.16893392 |
| 14 | Myositis (HP:0100614) | 4.13257808 |
| 15 | Periodontitis (HP:0000704) | 4.05635899 |
| 16 | Vacuolated lymphocytes (HP:0001922) | 3.97990850 |
| 17 | Recurrent fungal infections (HP:0002841) | 3.75335350 |
| 18 | Systemic lupus erythematosus (HP:0002725) | 3.70507574 |
| 19 | Orchitis (HP:0100796) | 3.69354253 |
| 20 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.55337747 |
| 21 | Increased cerebral lipofuscin (HP:0011813) | 3.53787141 |
| 22 | Retrobulbar optic neuritis (HP:0100654) | 3.35155182 |
| 23 | Optic neuritis (HP:0100653) | 3.35155182 |
| 24 | Cellulitis (HP:0100658) | 3.33080325 |
| 25 | T lymphocytopenia (HP:0005403) | 3.28999502 |
| 26 | Urticaria (HP:0001025) | 3.27574187 |
| 27 | Meningitis (HP:0001287) | 3.25776161 |
| 28 | Encephalitis (HP:0002383) | 3.22557020 |
| 29 | Vasculitis (HP:0002633) | 3.21545764 |
| 30 | Abnormality of T cell number (HP:0011839) | 3.19345542 |
| 31 | Abnormality of the prostate (HP:0008775) | 3.14974429 |
| 32 | Thrombocytosis (HP:0001894) | 3.14600907 |
| 33 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 3.13270689 |
| 34 | Recurrent viral infections (HP:0004429) | 3.11032631 |
| 35 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.05933247 |
| 36 | Eosinophilia (HP:0001880) | 2.97277088 |
| 37 | Agnosia (HP:0010524) | 2.96971056 |
| 38 | Axonal loss (HP:0003447) | 2.96129150 |
| 39 | Pulmonary infiltrates (HP:0002113) | 2.94883226 |
| 40 | Recurrent pneumonia (HP:0006532) | 2.94067084 |
| 41 | Prostate neoplasm (HP:0100787) | 2.93138828 |
| 42 | Basal ganglia calcification (HP:0002135) | 2.92885835 |
| 43 | Pustule (HP:0200039) | 2.91690323 |
| 44 | Leukocytosis (HP:0001974) | 2.91589983 |
| 45 | Loss of speech (HP:0002371) | 2.88916972 |
| 46 | Joint hemorrhage (HP:0005261) | 2.81245599 |
| 47 | Disinhibition (HP:0000734) | 2.79643293 |
| 48 | Spontaneous hematomas (HP:0007420) | 2.79279137 |
| 49 | Osteomyelitis (HP:0002754) | 2.74589867 |
| 50 | Petechiae (HP:0000967) | 2.72727547 |
| 51 | Abnormality of glycolipid metabolism (HP:0010969) | 2.67589294 |
| 52 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.67589294 |
| 53 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.67589294 |
| 54 | Glomerulonephritis (HP:0000099) | 2.65067831 |
| 55 | Granulocytopenia (HP:0001913) | 2.63025505 |
| 56 | Anorexia (HP:0002039) | 2.62729839 |
| 57 | Pulmonary embolism (HP:0002204) | 2.62147189 |
| 58 | Recurrent cutaneous fungal infections (HP:0011370) | 2.60264564 |
| 59 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.60264564 |
| 60 | Interstitial pulmonary disease (HP:0006530) | 2.57588362 |
| 61 | Thick nail (HP:0001805) | 2.56658865 |
| 62 | Hypergammaglobulinemia (HP:0010702) | 2.49277060 |
| 63 | Hemoptysis (HP:0002105) | 2.46831145 |
| 64 | Episodic fever (HP:0001954) | 2.43890750 |
| 65 | Keratoconjunctivitis sicca (HP:0001097) | 2.43336310 |
| 66 | Recurrent lower respiratory tract infections (HP:0002783) | 2.43156198 |
| 67 | Hepatosplenomegaly (HP:0001433) | 2.42858527 |
| 68 | Sepsis (HP:0100806) | 2.42661065 |
| 69 | Dysostosis multiplex (HP:0000943) | 2.41275348 |
| 70 | Purpura (HP:0000979) | 2.34634170 |
| 71 | Prolonged bleeding time (HP:0003010) | 2.33089567 |
| 72 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.32408044 |
| 73 | Abnormality of eosinophils (HP:0001879) | 2.29844152 |
| 74 | Abnormality of the pleura (HP:0002103) | 2.29576534 |
| 75 | Increased IgM level (HP:0003496) | 2.28785440 |
| 76 | Gingival bleeding (HP:0000225) | 2.27572089 |
| 77 | Peritonitis (HP:0002586) | 2.26931534 |
| 78 | Increased IgE level (HP:0003212) | 2.26444168 |
| 79 | Polyneuropathy (HP:0001271) | 2.25979736 |
| 80 | Skin ulcer (HP:0200042) | 2.24655128 |
| 81 | Hypochromic microcytic anemia (HP:0004840) | 2.21210704 |
| 82 | Chest pain (HP:0100749) | 2.21065494 |
| 83 | Keratoconjunctivitis (HP:0001096) | 2.20102398 |
| 84 | Epistaxis (HP:0000421) | 2.20005065 |
| 85 | Mutism (HP:0002300) | 2.18379887 |
| 86 | Papilledema (HP:0001085) | 2.17076459 |
| 87 | Vertigo (HP:0002321) | 2.16084725 |
| 88 | Poor head control (HP:0002421) | 2.14625281 |
| 89 | Mucopolysacchariduria (HP:0008155) | 2.11019516 |
| 90 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.11019516 |
| 91 | Increased serum ferritin (HP:0003281) | 2.10362294 |
| 92 | Gangrene (HP:0100758) | 2.08887357 |
| 93 | Nausea (HP:0002018) | 2.07624429 |
| 94 | Abnormality of T cell physiology (HP:0011840) | 2.07513131 |
| 95 | Hypochromic anemia (HP:0001931) | 2.06736193 |
| 96 | Abnormality of the endocardium (HP:0004306) | 2.03935175 |
| 97 | Myocardial infarction (HP:0001658) | 2.03679454 |
| 98 | Glomerulopathy (HP:0100820) | 2.02543475 |
| 99 | Arterial thrombosis (HP:0004420) | 2.02006457 |
| 100 | Abnormality of iron homeostasis (HP:0011031) | 2.01486477 |
| 101 | Cheilitis (HP:0100825) | 2.01173547 |
| 102 | Inflammation of the large intestine (HP:0002037) | 1.99938957 |
| 103 | Gastrointestinal infarctions (HP:0005244) | 1.99268095 |
| 104 | Reduced antithrombin III activity (HP:0001976) | 1.97816828 |
| 105 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.96242900 |
| 106 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.96242900 |
| 107 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.96242900 |
| 108 | Tetraparesis (HP:0002273) | 1.94948785 |
| 109 | Abnormality of the peritoneum (HP:0002585) | 1.93459285 |
| 110 | Chronic otitis media (HP:0000389) | 1.93278433 |
| 111 | Keratitis (HP:0000491) | 1.90477762 |
| 112 | Abnormality of the pericardium (HP:0001697) | 1.89913516 |
| 113 | Inappropriate behavior (HP:0000719) | 1.87123523 |
| 114 | Restrictive lung disease (HP:0002091) | 1.87036569 |
| 115 | Premature loss of primary teeth (HP:0006323) | 1.86042184 |
| 116 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.84945115 |
| 117 | IgM deficiency (HP:0002850) | 1.82441813 |
| 118 | Pathologic fracture (HP:0002756) | 1.82167892 |
| 119 | Nephritis (HP:0000123) | 1.81388473 |
| 120 | Abnormality of T cells (HP:0002843) | 1.80913785 |
| 121 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.78448699 |
| 122 | Hematochezia (HP:0002573) | 1.77477773 |
| 123 | Amyloidosis (HP:0011034) | 1.77393204 |
| 124 | Chromsome breakage (HP:0040012) | 1.75742966 |
| 125 | Esophageal neoplasm (HP:0100751) | 1.74861463 |
| 126 | Neoplasm of head and neck (HP:0012288) | 1.74861463 |
| 127 | Bone pain (HP:0002653) | 1.73409230 |
| 128 | Neutropenia (HP:0001875) | 1.73085889 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 4.86508620 |
| 2 | IRAK4 | 4.72512672 |
| 3 | BLK | 4.52427786 |
| 4 | MAP3K14 | 4.14916249 |
| 5 | IRAK3 | 3.22534287 |
| 6 | TXK | 2.84906899 |
| 7 | TBK1 | 2.61128479 |
| 8 | MAP4K1 | 2.50799370 |
| 9 | TYK2 | 2.18932374 |
| 10 | ERN1 | 2.13375681 |
| 11 | IKBKE | 2.12452373 |
| 12 | KIT | 1.88821945 |
| 13 | TEC | 1.88621786 |
| 14 | ZAP70 | 1.84852607 |
| 15 | PBK | 1.83994697 |
| 16 | JAK3 | 1.71447216 |
| 17 | BTK | 1.70760188 |
| 18 | CSK | 1.68703573 |
| 19 | IKBKB | 1.62668019 |
| 20 | PIM2 | 1.61372390 |
| 21 | SYK | 1.60001652 |
| 22 | TAOK3 | 1.57518899 |
| 23 | TNK2 | 1.56970403 |
| 24 | CLK1 | 1.55889615 |
| 25 | JAK1 | 1.44034883 |
| 26 | TESK1 | 1.42879243 |
| 27 | HCK | 1.38703031 |
| 28 | FES | 1.38150065 |
| 29 | TAOK1 | 1.37164456 |
| 30 | ACVR1B | 1.35928973 |
| 31 | MAP2K3 | 1.35769322 |
| 32 | LYN | 1.35683137 |
| 33 | MAP3K12 | 1.31945554 |
| 34 | EPHB1 | 1.27195549 |
| 35 | FGR | 1.25995078 |
| 36 | EIF2AK2 | 1.18659694 |
| 37 | CDK19 | 1.16771610 |
| 38 | CSF1R | 1.15151962 |
| 39 | ABL2 | 1.14028430 |
| 40 | TRPM7 | 1.08076531 |
| 41 | ERBB3 | 1.07812123 |
| 42 | NEK9 | 1.05142001 |
| 43 | RPS6KA4 | 1.02792588 |
| 44 | PIM1 | 1.02529767 |
| 45 | LCK | 1.00994472 |
| 46 | YES1 | 1.00405381 |
| 47 | EIF2AK3 | 0.98828987 |
| 48 | CHUK | 0.98339616 |
| 49 | STK10 | 0.97109348 |
| 50 | JAK2 | 0.95883696 |
| 51 | MATK | 0.95000993 |
| 52 | PRKCD | 0.94261501 |
| 53 | TESK2 | 0.92775868 |
| 54 | STK4 | 0.83894211 |
| 55 | MAP3K2 | 0.83867247 |
| 56 | PDK1 | 0.83464651 |
| 57 | FRK | 0.82449134 |
| 58 | ITK | 0.82398600 |
| 59 | DAPK2 | 0.80001245 |
| 60 | KSR2 | 0.76405565 |
| 61 | BRSK2 | 0.74759246 |
| 62 | BMPR2 | 0.72739606 |
| 63 | MAP3K13 | 0.71849782 |
| 64 | MARK3 | 0.70136529 |
| 65 | PDPK1 | 0.69979039 |
| 66 | CAMKK2 | 0.68838881 |
| 67 | TAOK2 | 0.68493096 |
| 68 | MAP2K6 | 0.66581268 |
| 69 | ABL1 | 0.65313363 |
| 70 | RPS6KA6 | 0.63797157 |
| 71 | CDC42BPA | 0.62140896 |
| 72 | PAK4 | 0.61060942 |
| 73 | PTK2B | 0.57571654 |
| 74 | TGFBR2 | 0.57027710 |
| 75 | PIK3CG | 0.56886112 |
| 76 | GRK7 | 0.56806102 |
| 77 | RPS6KL1 | 0.55671372 |
| 78 | RPS6KC1 | 0.55671372 |
| 79 | MAP2K4 | 0.55438304 |
| 80 | NME2 | 0.55320600 |
| 81 | BMX | 0.53215147 |
| 82 | CDK4 | 0.52511829 |
| 83 | EGFR | 0.51704879 |
| 84 | EPHA3 | 0.50913765 |
| 85 | RIPK1 | 0.49511814 |
| 86 | EIF2AK1 | 0.49185635 |
| 87 | MST1R | 0.49040367 |
| 88 | OXSR1 | 0.48449380 |
| 89 | STK11 | 0.48298042 |
| 90 | MAP3K5 | 0.46715995 |
| 91 | MARK2 | 0.45715477 |
| 92 | MAPK12 | 0.45590937 |
| 93 | CDK6 | 0.45134900 |
| 94 | MOS | 0.44353232 |
| 95 | GRK6 | 0.43746721 |
| 96 | CAMKK1 | 0.43123525 |
| 97 | MAPK4 | 0.42416165 |
| 98 | SIK3 | 0.42174522 |
| 99 | IRAK2 | 0.41975649 |
| 100 | RPS6KA2 | 0.41607257 |
| 101 | SGK3 | 0.41262769 |
| 102 | SGK2 | 0.40552638 |
| 103 | PRPF4B | 0.40505185 |
| 104 | ADRBK2 | 0.39692926 |
| 105 | IRAK1 | 0.38955601 |
| 106 | MAPK7 | 0.38835773 |
| 107 | MAP3K11 | 0.38816440 |
| 108 | FYN | 0.37431846 |
| 109 | FGFR3 | 0.36917916 |
| 110 | MAPKAPK2 | 0.36243248 |
| 111 | MAP3K3 | 0.35571843 |
| 112 | PRKCQ | 0.35416104 |
| 113 | ATR | 0.33177129 |
| 114 | TTN | 0.33169788 |
| 115 | MAP3K6 | 0.33079920 |
| 116 | PRKD2 | 0.32718274 |
| 117 | HIPK2 | 0.32698684 |
| 118 | DYRK1B | 0.31195766 |
| 119 | PTK6 | 0.31183566 |
| 120 | KSR1 | 0.29601778 |
| 121 | MST4 | 0.29182216 |
| 122 | PRKG2 | 0.28279323 |
| 123 | WNK1 | 0.28204094 |
| 124 | LRRK2 | 0.27505057 |
| 125 | DAPK1 | 0.25989364 |
| 126 | LIMK1 | 0.25165866 |
| 127 | ZAK | 0.23811297 |
| 128 | MAP3K8 | 0.23548800 |
| 129 | ARAF | 0.22527637 |
| 130 | FLT3 | 0.22262453 |
| 131 | SIK2 | 0.22072229 |
| 132 | MAP3K1 | 0.21211254 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 4.00475212 |
| 2 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.44068470 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.04608625 |
| 4 | Legionellosis_Homo sapiens_hsa05134 | 2.91335832 |
| 5 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.69639391 |
| 6 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.60716203 |
| 7 | Pertussis_Homo sapiens_hsa05133 | 2.59267707 |
| 8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.49294181 |
| 9 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.48824101 |
| 10 | Tuberculosis_Homo sapiens_hsa05152 | 2.41719382 |
| 11 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.41099521 |
| 12 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.27955714 |
| 13 | Malaria_Homo sapiens_hsa05144 | 2.24925777 |
| 14 | Phagosome_Homo sapiens_hsa04145 | 2.17215894 |
| 15 | Asthma_Homo sapiens_hsa05310 | 2.14360114 |
| 16 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.09121703 |
| 17 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.03429764 |
| 18 | Lysosome_Homo sapiens_hsa04142 | 1.99691978 |
| 19 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.96543949 |
| 20 | Salmonella infection_Homo sapiens_hsa05132 | 1.93936549 |
| 21 | Measles_Homo sapiens_hsa05162 | 1.89794439 |
| 22 | Allograft rejection_Homo sapiens_hsa05330 | 1.80700826 |
| 23 | Other glycan degradation_Homo sapiens_hsa00511 | 1.71743141 |
| 24 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.70969466 |
| 25 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.70234012 |
| 26 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.67576392 |
| 27 | Influenza A_Homo sapiens_hsa05164 | 1.63429136 |
| 28 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.60219507 |
| 29 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.60072380 |
| 30 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.57796723 |
| 31 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.54922165 |
| 32 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.53769624 |
| 33 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.51019622 |
| 34 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.34189061 |
| 35 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.33457506 |
| 36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.27408921 |
| 37 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.26632300 |
| 38 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.23591600 |
| 39 | Apoptosis_Homo sapiens_hsa04210 | 1.22439433 |
| 40 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.22277491 |
| 41 | Shigellosis_Homo sapiens_hsa05131 | 1.15758976 |
| 42 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.05512240 |
| 43 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.04646924 |
| 44 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.01984400 |
| 45 | Hepatitis B_Homo sapiens_hsa05161 | 0.93709781 |
| 46 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.92703932 |
| 47 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.88555672 |
| 48 | Amoebiasis_Homo sapiens_hsa05146 | 0.88485711 |
| 49 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.86742871 |
| 50 | Hepatitis C_Homo sapiens_hsa05160 | 0.84697217 |
| 51 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83359967 |
| 52 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73193469 |
| 53 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.73146333 |
| 54 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.71260306 |
| 55 | Viral myocarditis_Homo sapiens_hsa05416 | 0.70951066 |
| 56 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.70907325 |
| 57 | DNA replication_Homo sapiens_hsa03030 | 0.69922603 |
| 58 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.69785589 |
| 59 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.67618839 |
| 60 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.66525298 |
| 61 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.62819695 |
| 62 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.62093402 |
| 63 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.60571775 |
| 64 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58023662 |
| 65 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.57780648 |
| 66 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.57394524 |
| 67 | Platelet activation_Homo sapiens_hsa04611 | 0.55776328 |
| 68 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.54034963 |
| 69 | Prion diseases_Homo sapiens_hsa05020 | 0.53746095 |
| 70 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.50288641 |
| 71 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.50225598 |
| 72 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.49852337 |
| 73 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.49319270 |
| 74 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.46957399 |
| 75 | Base excision repair_Homo sapiens_hsa03410 | 0.46344309 |
| 76 | Endocytosis_Homo sapiens_hsa04144 | 0.43397360 |
| 77 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.42740447 |
| 78 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.42685023 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.42262475 |
| 80 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.41623421 |
| 81 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.41234738 |
| 82 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.40607961 |
| 83 | Homologous recombination_Homo sapiens_hsa03440 | 0.39545510 |
| 84 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.38713476 |
| 85 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.38363392 |
| 86 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.37923359 |
| 87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.37654580 |
| 88 | Galactose metabolism_Homo sapiens_hsa00052 | 0.37347299 |
| 89 | Proteasome_Homo sapiens_hsa03050 | 0.35230148 |
| 90 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.33584613 |
| 91 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.31680076 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.31154623 |
| 93 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29539833 |
| 94 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.29432791 |
| 95 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.28269447 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.27912329 |
| 97 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.26734619 |
| 98 | Protein export_Homo sapiens_hsa03060 | 0.26512207 |
| 99 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.26375675 |
| 100 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.25073163 |
| 101 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.24878616 |
| 102 | Mineral absorption_Homo sapiens_hsa04978 | 0.24675954 |
| 103 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.24330167 |
| 104 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.24247311 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.23938960 |
| 106 | HTLV-I infection_Homo sapiens_hsa05166 | 0.21995596 |
| 107 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.21715434 |
| 108 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.20502084 |
| 109 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.20168704 |
| 110 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.19554733 |
| 111 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.19516074 |
| 112 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.19149255 |
| 113 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.19036015 |
| 114 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.18456020 |
| 115 | Insulin resistance_Homo sapiens_hsa04931 | 0.18188507 |
| 116 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.17679090 |
| 117 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.17274422 |
| 118 | ABC transporters_Homo sapiens_hsa02010 | 0.16089985 |
| 119 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.15710218 |
| 120 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.14720435 |

