IGSF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.66882659
2axon ensheathment in central nervous system (GO:0032291)5.66882659
3synaptic vesicle maturation (GO:0016188)5.26751363
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19387856
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53964346
6synaptic vesicle exocytosis (GO:0016079)4.46545096
7locomotory exploration behavior (GO:0035641)4.41203592
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.40217342
9regulation of synaptic vesicle exocytosis (GO:2000300)4.18377851
10regulation of ARF protein signal transduction (GO:0032012)4.18281964
11glutamate secretion (GO:0014047)4.13691446
12neuronal action potential propagation (GO:0019227)4.08640498
13neuron cell-cell adhesion (GO:0007158)4.00962309
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99201462
15myelination (GO:0042552)3.96296572
16ensheathment of neurons (GO:0007272)3.95149165
17axon ensheathment (GO:0008366)3.95149165
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90717471
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.87537900
20regulation of neuronal synaptic plasticity (GO:0048168)3.85710316
21vocalization behavior (GO:0071625)3.85578990
22layer formation in cerebral cortex (GO:0021819)3.84834140
23dendritic spine morphogenesis (GO:0060997)3.83908222
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79269918
25neuronal ion channel clustering (GO:0045161)3.77774739
26protein localization to synapse (GO:0035418)3.72066496
27transmission of nerve impulse (GO:0019226)3.71696136
28cell communication by electrical coupling (GO:0010644)3.68174279
29regulation of glutamate receptor signaling pathway (GO:1900449)3.63124760
30L-amino acid import (GO:0043092)3.62606972
31regulation of synapse maturation (GO:0090128)3.60084664
32negative regulation of neurotransmitter secretion (GO:0046929)3.59613071
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59404399
34regulation of synaptic vesicle transport (GO:1902803)3.55148090
35sodium ion export (GO:0071436)3.54198645
36regulation of neurotransmitter levels (GO:0001505)3.54043984
37cellular potassium ion homeostasis (GO:0030007)3.51433297
38synaptic transmission, glutamatergic (GO:0035249)3.47472214
39regulation of synapse structural plasticity (GO:0051823)3.47203400
40adult walking behavior (GO:0007628)3.46984582
41positive regulation of neurotransmitter secretion (GO:0001956)3.46733395
42neuron recognition (GO:0008038)3.45460053
43mating behavior (GO:0007617)3.44711988
44axonal fasciculation (GO:0007413)3.43131474
45cellular sodium ion homeostasis (GO:0006883)3.43060848
46glutamate receptor signaling pathway (GO:0007215)3.42390858
47negative regulation of neurotransmitter transport (GO:0051589)3.42144275
48postsynaptic membrane organization (GO:0001941)3.41626945
49gamma-aminobutyric acid transport (GO:0015812)3.39859763
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.39321080
51exploration behavior (GO:0035640)3.35161164
52positive regulation of neurotransmitter transport (GO:0051590)3.31958328
53presynaptic membrane organization (GO:0097090)3.31004832
54nerve growth factor signaling pathway (GO:0038180)3.26740469
55long-chain fatty acid biosynthetic process (GO:0042759)3.26416917
56neurotransmitter secretion (GO:0007269)3.26099382
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.26055635
58cerebellar granule cell differentiation (GO:0021707)3.23795504
59synaptic vesicle docking involved in exocytosis (GO:0016081)3.23608850
60neuron-neuron synaptic transmission (GO:0007270)3.22239613
61dendrite morphogenesis (GO:0048813)3.22196113
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21816038
63acidic amino acid transport (GO:0015800)3.19555678
64positive regulation of membrane potential (GO:0045838)3.19134521
65regulation of dendritic spine morphogenesis (GO:0061001)3.17827616
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.14455559
67long-term memory (GO:0007616)3.12761106
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.09769965
69synaptic vesicle endocytosis (GO:0048488)3.08968710
70neuromuscular process controlling posture (GO:0050884)3.08949649
71negative regulation of axonogenesis (GO:0050771)3.08501781
72regulation of synaptic plasticity (GO:0048167)3.08150458
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05334486
74neuromuscular process controlling balance (GO:0050885)3.04387916
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03743717
76dicarboxylic acid transport (GO:0006835)3.01644775
77glycine transport (GO:0015816)3.00655999
78amino acid import (GO:0043090)3.00500539
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.99887087
80presynaptic membrane assembly (GO:0097105)2.99264969
81positive regulation of dendritic spine morphogenesis (GO:0061003)2.98457593
82negative regulation of dendrite morphogenesis (GO:0050774)2.94961428
83regulation of postsynaptic membrane potential (GO:0060078)2.94783582
84dendritic spine organization (GO:0097061)2.90146321
85establishment of mitochondrion localization (GO:0051654)2.89125319
86response to auditory stimulus (GO:0010996)2.87984785
87regulation of neurotransmitter secretion (GO:0046928)2.87388696
88signal complex assembly (GO:0007172)2.86727840
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85210280
90regulation of dendritic spine development (GO:0060998)2.84979602
91cerebellar Purkinje cell differentiation (GO:0021702)2.84515242
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84069837
93membrane hyperpolarization (GO:0060081)2.83821844
94L-glutamate transport (GO:0015813)2.83501210
95oligodendrocyte differentiation (GO:0048709)2.83093915
96positive regulation of dendritic spine development (GO:0060999)2.82248758
97protein retention in ER lumen (GO:0006621)2.81501624
98cell communication involved in cardiac conduction (GO:0086065)2.81204602
99neurotransmitter-gated ion channel clustering (GO:0072578)2.81101281
100regulation of synaptic transmission (GO:0050804)2.80987988
101long-term synaptic potentiation (GO:0060291)2.80891729
102cerebellar Purkinje cell layer development (GO:0021680)2.80152856
103neurotransmitter transport (GO:0006836)2.79564901
104regulation of vesicle fusion (GO:0031338)2.78514871
105cell migration in hindbrain (GO:0021535)2.77015805
106apical protein localization (GO:0045176)2.76479304
107regulation of voltage-gated calcium channel activity (GO:1901385)2.76303006
108negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75404742
109establishment of synaptic vesicle localization (GO:0097480)2.74644340
110synaptic vesicle transport (GO:0048489)2.74644340
111myelin maintenance (GO:0043217)2.69887193
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68945571
113proline transport (GO:0015824)2.68395910
114potassium ion homeostasis (GO:0055075)2.68332501
115regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68261782
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68122645
117organelle transport along microtubule (GO:0072384)2.67074152
118regulation of neurotransmitter transport (GO:0051588)2.66712182
119negative regulation of amino acid transport (GO:0051956)2.66409993
120positive regulation of dendrite development (GO:1900006)2.66400947
121activation of protein kinase A activity (GO:0034199)2.65790612
122potassium ion import (GO:0010107)2.65722627
123auditory behavior (GO:0031223)2.65667513
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.65604659
125positive regulation of synapse maturation (GO:0090129)2.65443534
126fatty acid elongation (GO:0030497)2.64528686
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64124679
128neuromuscular process (GO:0050905)2.60657629
129vesicle docking involved in exocytosis (GO:0006904)2.58317287
130dopamine receptor signaling pathway (GO:0007212)2.56609159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55573471
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09198520
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07969222
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01935896
5GBX2_23144817_ChIP-Seq_PC3_Human2.96553322
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84169977
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84169977
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.75898571
9DROSHA_22980978_ChIP-Seq_HELA_Human2.71758376
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.71384565
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66395531
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65223324
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54729899
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54069481
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52430088
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51469339
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.49360236
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.45499533
19REST_21632747_ChIP-Seq_MESCs_Mouse2.41905761
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.34708622
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31084593
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.30018342
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20161550
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19501926
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.12479882
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99089516
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.95634540
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94692940
29* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91746768
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86315606
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.85317323
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72181806
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68561774
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65751084
35AR_21572438_ChIP-Seq_LNCaP_Human1.65305195
36SMC4_20622854_ChIP-Seq_HELA_Human1.64647762
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64310697
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63567831
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61462417
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.58137416
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55917933
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54813532
43P68_20966046_ChIP-Seq_HELA_Human1.52139973
44KDM2B_26808549_Chip-Seq_K562_Human1.51292494
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50024270
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48449441
47* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45399750
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43558486
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42110104
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41904617
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40864138
52* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40418563
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.40182342
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.40174344
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40109672
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39498203
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.39184279
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38507515
59* CREB1_26743006_Chip-Seq_LNCaP_Human1.37338521
60* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36387591
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31700440
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30205996
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27059861
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26315292
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26004087
66* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23614490
67* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23545487
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23291859
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21056736
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20659395
71* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19451466
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19090948
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16351782
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16249245
75* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14777084
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14125939
77OCT4_19829295_ChIP-Seq_ESCs_Human1.13499008
78* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12820062
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12152241
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11220915
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10725830
82SA1_27219007_Chip-Seq_Bcells_Human1.09692555
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09038796
84SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08985554
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.08409134
86CTCF_27219007_Chip-Seq_Bcells_Human1.07651855
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.06141212
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04211159
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04203499
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.03481460
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03202809
92VDR_21846776_ChIP-Seq_THP-1_Human1.03028461
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02693279
94ZNF274_21170338_ChIP-Seq_K562_Hela1.02640412
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01573324
96* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01002099
97EGR1_19032775_ChIP-ChIP_M12_Human1.00458659
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00357049
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00013574
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.99941400
101AR_19668381_ChIP-Seq_PC3_Human0.99663952
102SMAD4_21799915_ChIP-Seq_A2780_Human0.99385481
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98824582
104CLOCK_20551151_ChIP-Seq_293T_Human0.98603310
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97914855
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97868425
107* LXR_22292898_ChIP-Seq_THP-1_Human0.97522804
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96980321
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95862031
110TAF15_26573619_Chip-Seq_HEK293_Human0.95587096
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94629812
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.94380960
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94262380
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94154739
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93633581
116* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93592899
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93529816
118ZNF263_19887448_ChIP-Seq_K562_Human0.92535609
119* TP63_22573176_ChIP-Seq_HFKS_Human0.92054316
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.91504635
121AHR_22903824_ChIP-Seq_MCF-7_Human0.88552773
122STAT3_23295773_ChIP-Seq_U87_Human0.88266449
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.87100359
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.85277511
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83755573
126TRIM28_21343339_ChIP-Seq_HEK293_Human0.83656436
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.83611124
128* KDM2B_26808549_Chip-Seq_DND41_Human0.83539040
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.81018850
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80803996
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.80558603
132* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80443470
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80217365
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79868719
135* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79012520
136ER_23166858_ChIP-Seq_MCF-7_Human0.78817802
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78170517
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.77501275
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74951039
140TCF4_23295773_ChIP-Seq_U87_Human0.74909454
141P300_19829295_ChIP-Seq_ESCs_Human0.74679197
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74667948
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.74519736
144KLF4_19829295_ChIP-Seq_ESCs_Human0.74312277
145AR_25329375_ChIP-Seq_VCAP_Human0.74216036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31211463
2MP0003880_abnormal_central_pattern4.46096036
3MP0004270_analgesia3.78549591
4MP0003635_abnormal_synaptic_transmissio3.71515561
5MP0002064_seizures3.24160753
6MP0009745_abnormal_behavioral_response3.09349598
7MP0009046_muscle_twitch2.92907125
8MP0000920_abnormal_myelination2.91562530
9MP0002063_abnormal_learning/memory/cond2.88874408
10MP0003329_amyloid_beta_deposits2.81232871
11MP0002272_abnormal_nervous_system2.69253999
12MP0005423_abnormal_somatic_nervous2.68079346
13MP0001486_abnormal_startle_reflex2.51763061
14MP0002572_abnormal_emotion/affect_behav2.43146812
15MP0002734_abnormal_mechanical_nocicepti2.35026832
16MP0004885_abnormal_endolymph2.27417863
17MP0000778_abnormal_nervous_system2.19402466
18MP0001968_abnormal_touch/_nociception2.12410067
19MP0003690_abnormal_glial_cell2.07259284
20MP0004858_abnormal_nervous_system2.04280384
21MP0001501_abnormal_sleep_pattern2.00188214
22MP0002822_catalepsy1.99938994
23MP0001440_abnormal_grooming_behavior1.88175300
24MP0003634_abnormal_glial_cell1.87607058
25MP0008569_lethality_at_weaning1.86517134
26MP0002733_abnormal_thermal_nociception1.81957126
27MP0000955_abnormal_spinal_cord1.79910136
28MP0001905_abnormal_dopamine_level1.78033808
29MP0001529_abnormal_vocalization1.77194447
30MP0001970_abnormal_pain_threshold1.76593069
31MP0004811_abnormal_neuron_physiology1.72041229
32MP0002735_abnormal_chemical_nociception1.70893436
33MP0002067_abnormal_sensory_capabilities1.70890044
34MP0002882_abnormal_neuron_morphology1.64541406
35MP0002736_abnormal_nociception_after1.64526316
36MP0000604_amyloidosis1.63905044
37MP0002184_abnormal_innervation1.60120581
38MP0004142_abnormal_muscle_tone1.58556283
39MP0003123_paternal_imprinting1.58301884
40MP0005171_absent_coat_pigmentation1.52843347
41MP0004924_abnormal_behavior1.52468413
42MP0005386_behavior/neurological_phenoty1.52468413
43MP0001984_abnormal_olfaction1.52291135
44MP0000579_abnormal_nail_morphology1.51694456
45MP0002066_abnormal_motor_capabilities/c1.49569505
46MP0003632_abnormal_nervous_system1.48019432
47MP0002089_abnormal_postnatal_growth/wei1.41921452
48MP0002229_neurodegeneration1.41249076
49MP0008260_abnormal_autophagy1.40604499
50MP0003075_altered_response_to1.40475725
51MP0003633_abnormal_nervous_system1.38667597
52MP0003705_abnormal_hypodermis_morpholog1.37281269
53MP0002557_abnormal_social/conspecific_i1.36918337
54MP0003631_nervous_system_phenotype1.35430521
55MP0004742_abnormal_vestibular_system1.33012295
56MP0001849_ear_inflammation1.27250457
57MP0002909_abnormal_adrenal_gland1.26164537
58MP0009780_abnormal_chondrocyte_physiolo1.26115494
59MP0001502_abnormal_circadian_rhythm1.24239628
60MP0001485_abnormal_pinna_reflex1.23605967
61MP0003172_abnormal_lysosome_physiology1.18836935
62MP0002152_abnormal_brain_morphology1.18220717
63MP0005645_abnormal_hypothalamus_physiol1.17461881
64MP0005623_abnormal_meninges_morphology1.09112585
65MP0002090_abnormal_vision1.07973994
66MP0009840_abnormal_foam_cell1.04233463
67MP0003879_abnormal_hair_cell1.02289795
68MP0005058_abnormal_lysosome_morphology1.01379356
69MP0001299_abnormal_eye_distance/1.01072614
70MP0002653_abnormal_ependyma_morphology0.99258181
71MP0005646_abnormal_pituitary_gland0.98543895
72MP0006276_abnormal_autonomic_nervous0.96285325
73MP0000566_synostosis0.95258438
74MP0002752_abnormal_somatic_nervous0.93365469
75MP0005551_abnormal_eye_electrophysiolog0.90240869
76MP0001963_abnormal_hearing_physiology0.88248492
77MP0001348_abnormal_lacrimal_gland0.87857908
78MP0004381_abnormal_hair_follicle0.87061941
79MP0003787_abnormal_imprinting0.82170335
80MP0002069_abnormal_eating/drinking_beha0.82116422
81MP0001177_atelectasis0.79266775
82MP0010234_abnormal_vibrissa_follicle0.79121011
83MP0000747_muscle_weakness0.77371282
84MP0000678_abnormal_parathyroid_gland0.77060025
85MP0008874_decreased_physiological_sensi0.74710681
86MP0003283_abnormal_digestive_organ0.73742278
87MP0003122_maternal_imprinting0.73057171
88MP0005535_abnormal_body_temperature0.71635762
89MP0005166_decreased_susceptibility_to0.70678564
90MP0000751_myopathy0.70080739
91MP0002249_abnormal_larynx_morphology0.69508400
92MP0005499_abnormal_olfactory_system0.68201515
93MP0005394_taste/olfaction_phenotype0.68201515
94MP0003861_abnormal_nervous_system0.65442742
95MP0004510_myositis0.64949879
96MP0003137_abnormal_impulse_conducting0.63081811
97MP0001943_abnormal_respiration0.61984570
98MP0004145_abnormal_muscle_electrophysio0.61594279
99MP0003183_abnormal_peptide_metabolism0.61315003
100MP0009672_abnormal_birth_weight0.60993393
101MP0000631_abnormal_neuroendocrine_gland0.60685828
102MP0001188_hyperpigmentation0.59332324
103MP0005410_abnormal_fertilization0.57511427
104MP0001346_abnormal_lacrimal_gland0.56926526
105MP0000013_abnormal_adipose_tissue0.56517105
106MP0010678_abnormal_skin_adnexa0.56372432
107MP0003453_abnormal_keratinocyte_physiol0.55623804
108MP0008961_abnormal_basal_metabolism0.55137500
109MP0003191_abnormal_cellular_cholesterol0.54733120
110MP0005409_darkened_coat_color0.53855456
111MP0005167_abnormal_blood-brain_barrier0.52459595
112MP0004085_abnormal_heartbeat0.51785634
113MP0000026_abnormal_inner_ear0.51488780
114MP0010769_abnormal_survival0.51458613
115MP0000681_abnormal_thyroid_gland0.51424304
116MP0000569_abnormal_digit_pigmentation0.49793034
117MP0005195_abnormal_posterior_eye0.48711322
118MP0010386_abnormal_urinary_bladder0.48139886
119MP0005257_abnormal_intraocular_pressure0.47929155
120MP0003303_peritoneal_inflammation0.47750755
121MP0010768_mortality/aging0.44431806
122MP0004947_skin_inflammation0.42621978
123MP0002873_normal_phenotype0.42608517
124MP0003956_abnormal_body_size0.41824073

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.19943471
2Neurofibrillary tangles (HP:0002185)5.36890716
3Supranuclear gaze palsy (HP:0000605)5.15641042
4Focal motor seizures (HP:0011153)5.01518633
5Cerebral inclusion bodies (HP:0100314)4.52510942
6Focal seizures (HP:0007359)4.18429155
7Visual hallucinations (HP:0002367)3.92675262
8Action tremor (HP:0002345)3.82411650
9Obstructive sleep apnea (HP:0002870)3.79942952
10Atonic seizures (HP:0010819)3.69473764
11Dysmetria (HP:0001310)3.63818851
12Ankle clonus (HP:0011448)3.58872777
13Intention tremor (HP:0002080)3.58183720
14Epileptic encephalopathy (HP:0200134)3.56440074
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.55104728
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.55104728
17Spastic gait (HP:0002064)3.54853703
18Abnormality of the corticospinal tract (HP:0002492)3.40173165
19Annular pancreas (HP:0001734)3.36814651
20Megalencephaly (HP:0001355)3.29973508
21Peripheral hypomyelination (HP:0007182)3.16955416
22Sensory axonal neuropathy (HP:0003390)3.14025555
23Absence seizures (HP:0002121)3.10286046
24Upper limb amyotrophy (HP:0009129)3.05053582
25Distal upper limb amyotrophy (HP:0007149)3.05053582
26Dialeptic seizures (HP:0011146)2.99132086
27Akinesia (HP:0002304)2.95653391
28Hand muscle atrophy (HP:0009130)2.90970592
29Insidious onset (HP:0003587)2.89819534
30Termporal pattern (HP:0011008)2.89819534
31Progressive cerebellar ataxia (HP:0002073)2.88415822
32Tetraplegia (HP:0002445)2.86623592
33Generalized tonic-clonic seizures (HP:0002069)2.74648666
34Abnormal eating behavior (HP:0100738)2.69439939
35Dysdiadochokinesis (HP:0002075)2.68247598
36Mutism (HP:0002300)2.67407433
37Scanning speech (HP:0002168)2.66085081
38Depression (HP:0000716)2.64620158
39Neuronal loss in central nervous system (HP:0002529)2.60127774
40Postural instability (HP:0002172)2.57417723
41Truncal ataxia (HP:0002078)2.55594533
42Gaze-evoked nystagmus (HP:0000640)2.52125266
43Lower limb muscle weakness (HP:0007340)2.47888539
44Delusions (HP:0000746)2.46868918
45Onion bulb formation (HP:0003383)2.46055223
46Urinary urgency (HP:0000012)2.44535453
47Pheochromocytoma (HP:0002666)2.42519563
48Urinary bladder sphincter dysfunction (HP:0002839)2.40901738
49Cerebral aneurysm (HP:0004944)2.40670589
50Anxiety (HP:0000739)2.37900451
51Thickened helices (HP:0000391)2.35951183
52Torticollis (HP:0000473)2.32341156
53Lower limb amyotrophy (HP:0007210)2.32078928
54Slow saccadic eye movements (HP:0000514)2.30637105
55Hyperacusis (HP:0010780)2.29807660
56Broad-based gait (HP:0002136)2.28861427
57Impaired vibration sensation in the lower limbs (HP:0002166)2.27591853
58Insomnia (HP:0100785)2.26570989
59Progressive inability to walk (HP:0002505)2.24672195
60Cerebral hypomyelination (HP:0006808)2.23349340
61Febrile seizures (HP:0002373)2.23328738
62Abnormal gallbladder physiology (HP:0012438)2.22921873
63Cholecystitis (HP:0001082)2.22921873
64Ocular albinism (HP:0001107)2.22083208
65Retinal dysplasia (HP:0007973)2.19589729
66Aplasia involving bones of the upper limbs (HP:0009823)2.18465425
67Aplasia of the phalanges of the hand (HP:0009802)2.18465425
68Aplasia involving bones of the extremities (HP:0009825)2.18465425
69Sleep apnea (HP:0010535)2.17661817
70Amblyopia (HP:0000646)2.15991911
71Status epilepticus (HP:0002133)2.14984978
72Hemiparesis (HP:0001269)2.13737871
73Clumsiness (HP:0002312)2.12647112
74Generalized myoclonic seizures (HP:0002123)2.11755561
75Apathy (HP:0000741)2.11121745
76Shallow orbits (HP:0000586)2.11120283
77Diplopia (HP:0000651)2.10937737
78Abnormality of binocular vision (HP:0011514)2.10937737
79Rapidly progressive (HP:0003678)2.10027667
80Spastic tetraparesis (HP:0001285)2.09397943
81Neuroendocrine neoplasm (HP:0100634)2.08601810
82Stridor (HP:0010307)2.07510355
83Poor eye contact (HP:0000817)2.07312124
84Iris hypopigmentation (HP:0007730)2.06939530
85Dementia (HP:0000726)2.05148601
86Increased cerebral lipofuscin (HP:0011813)2.03983669
87Focal dystonia (HP:0004373)2.03798449
88Alacrima (HP:0000522)2.03537957
89Papilledema (HP:0001085)1.99732102
90Clonus (HP:0002169)1.99067218
91Heterochromia iridis (HP:0001100)1.98095323
92Achilles tendon contracture (HP:0001771)1.98035392
93Loss of speech (HP:0002371)1.97769363
94Pointed chin (HP:0000307)1.95420674
95Abnormality of saccadic eye movements (HP:0000570)1.95064031
96Rigidity (HP:0002063)1.93744862
97Abnormality of the lower motor neuron (HP:0002366)1.91646885
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.91112142
99Abnormality of glycolipid metabolism (HP:0010969)1.91112142
100Abnormality of liposaccharide metabolism (HP:0010968)1.91112142
101Lower limb asymmetry (HP:0100559)1.91043667
102Stereotypic behavior (HP:0000733)1.90176281
103Abnormality of the periventricular white matter (HP:0002518)1.89443787
104Abnormal social behavior (HP:0012433)1.89102754
105Impaired social interactions (HP:0000735)1.89102754
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88931712
107Drooling (HP:0002307)1.88542811
108Excessive salivation (HP:0003781)1.88542811
109Spinal canal stenosis (HP:0003416)1.87375235
110Diminished motivation (HP:0000745)1.87329929
111Hammertoe (HP:0001765)1.85473299
112Craniofacial dystonia (HP:0012179)1.85409961
113Abnormality of the Achilles tendon (HP:0005109)1.84793642
114Anteriorly placed anus (HP:0001545)1.84382385
115Psychosis (HP:0000709)1.83142241
116Increased circulating renin level (HP:0000848)1.83070797
117Overriding aorta (HP:0002623)1.81728412
118Growth hormone excess (HP:0000845)1.81205663
119Hemiplegia (HP:0002301)1.80626334
120Deep venous thrombosis (HP:0002625)1.76837492
121Choreoathetosis (HP:0001266)1.76766183
122Foot dorsiflexor weakness (HP:0009027)1.76668709
123Bronchomalacia (HP:0002780)1.76194972
124Limb dystonia (HP:0002451)1.76126504
125J-shaped sella turcica (HP:0002680)1.76006812
126Dysostosis multiplex (HP:0000943)1.75846943
127Turricephaly (HP:0000262)1.75705011
128Axonal loss (HP:0003447)1.75580559
129Impaired smooth pursuit (HP:0007772)1.74825462
130Distal sensory impairment (HP:0002936)1.74757329
131Epileptiform EEG discharges (HP:0011182)1.73651831
132Bradykinesia (HP:0002067)1.73107963
133Urinary incontinence (HP:0000020)1.72767385
134Nuclear cataract (HP:0100018)1.72650345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.63778452
2EPHA43.47576962
3STK392.86906216
4NTRK32.83296905
5PAK62.81914914
6CDK192.55995925
7OXSR12.45852103
8PRPF4B2.43638237
9NTRK12.39454063
10KSR22.29090002
11TRIB32.17029060
12MARK12.03157808
13ARAF1.90612454
14MINK11.89999198
15DAPK21.87447703
16ICK1.86798443
17UHMK11.82781197
18NTRK21.82749995
19BCR1.82508681
20MAP3K131.74059278
21TYRO31.69157899
22EPHB11.63934637
23PRKD31.63481135
24LATS21.62895882
25CDK51.57713123
26TNIK1.53797834
27TESK11.49993946
28CAMKK11.47437800
29MAP3K111.46086308
30KSR11.45686586
31MAP3K41.34792684
32FGR1.33263669
33LIMK11.29462763
34CAMK2B1.28006587
35FGFR21.26730916
36CDK141.24147450
37CDK151.22011353
38CDK181.20526343
39WNK11.19044129
40MET1.16312125
41SIK11.13801092
42PKN11.11384785
43PAK31.09246874
44WNK41.08150655
45CDK11A1.07419771
46ROCK21.06780971
47RIPK41.06112762
48CSNK1G21.06085625
49PNCK1.05925587
50ERN11.04608574
51BMX1.04015045
52FGFR41.03662820
53FES1.02998453
54NEK61.01354088
55SIK20.99404710
56SMG10.96558825
57LMTK20.96426670
58CSNK1G30.96289196
59MARK20.94049365
60CAMK2D0.93875337
61GRK50.92335207
62DDR20.91998982
63CAMK2A0.91389359
64PRKCH0.90340410
65MAPKAPK50.86884051
66CSNK1A1L0.86284468
67STK110.85669509
68MAPK120.84881496
69ALK0.82332291
70SGK2230.81787864
71SGK4940.81787864
72PHKG20.81587312
73PHKG10.81587312
74CAMK2G0.80552309
75TAOK20.80409292
76PDGFRA0.79444354
77PLK20.77372754
78EEF2K0.75825735
79PRKCG0.74533979
80PDPK10.72958338
81FYN0.70950842
82MAP3K20.70252466
83BRAF0.68668234
84RET0.67923901
85RAF10.67850849
86MAP2K70.67418700
87RPS6KA20.63841754
88PTK2B0.62074613
89CAMK1G0.60953892
90CAMKK20.60890175
91SGK30.59910913
92DAPK10.59823401
93CASK0.59584637
94MAP2K40.59035400
95PRKG20.57148037
96PTK20.56581265
97TAOK10.54631836
98CAMK10.53759838
99MOS0.53716677
100PDK10.52727264
101PRKD20.52457482
102CSNK1G10.51336437
103BRSK10.51274583
104MAP3K10.50224725
105DAPK30.48870831
106CAMK40.48197840
107DYRK1A0.47714742
108TNK20.46937152
109MAPK130.45803520
110RIPK10.44997463
111PRKCZ0.43157030
112MAPK100.42842367
113CDC42BPA0.41322787
114ERBB20.39758821
115PRKCE0.39580086
116SRC0.39424626
117CLK10.39410736
118SGK10.39117406
119HIPK20.38958667
120PBK0.37738974
121PRKD10.37638821
122STK380.37058622
123PRKCQ0.36755143
124MAPK40.36477060
125IRAK20.36459619
126TESK20.36292211
127MAPK70.35744343
128RPS6KA30.35076860
129CDK120.35045955
130DYRK1B0.35030176
131MAP2K60.33321336

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.02987098
2Nicotine addiction_Homo sapiens_hsa050332.73576806
3Olfactory transduction_Homo sapiens_hsa047402.64268756
4GABAergic synapse_Homo sapiens_hsa047272.56638771
5Circadian entrainment_Homo sapiens_hsa047132.40191567
6Glutamatergic synapse_Homo sapiens_hsa047242.36774832
7Morphine addiction_Homo sapiens_hsa050322.30466910
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29113538
9Long-term potentiation_Homo sapiens_hsa047202.03307782
10Salivary secretion_Homo sapiens_hsa049701.94125688
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88571653
12Dopaminergic synapse_Homo sapiens_hsa047281.86582242
13Amphetamine addiction_Homo sapiens_hsa050311.79843535
14Axon guidance_Homo sapiens_hsa043601.74336811
15Cholinergic synapse_Homo sapiens_hsa047251.72754439
16Gastric acid secretion_Homo sapiens_hsa049711.68089987
17Collecting duct acid secretion_Homo sapiens_hsa049661.65558268
18Serotonergic synapse_Homo sapiens_hsa047261.64341235
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60099341
20Long-term depression_Homo sapiens_hsa047301.59523774
21Cocaine addiction_Homo sapiens_hsa050301.58726230
22Insulin secretion_Homo sapiens_hsa049111.56558592
23Vitamin B6 metabolism_Homo sapiens_hsa007501.56089269
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55831800
25Vibrio cholerae infection_Homo sapiens_hsa051101.46727585
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44889087
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41295930
28Oxytocin signaling pathway_Homo sapiens_hsa049211.37010185
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28576805
30Gap junction_Homo sapiens_hsa045401.28240332
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25432074
32GnRH signaling pathway_Homo sapiens_hsa049121.25082933
33Renin secretion_Homo sapiens_hsa049241.23425789
34Calcium signaling pathway_Homo sapiens_hsa040201.19963202
35ErbB signaling pathway_Homo sapiens_hsa040121.19649886
36Bile secretion_Homo sapiens_hsa049761.19080648
37Taste transduction_Homo sapiens_hsa047421.17354787
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16056762
39cAMP signaling pathway_Homo sapiens_hsa040241.15201237
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.15085671
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15078682
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14107994
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11980991
44Estrogen signaling pathway_Homo sapiens_hsa049151.06646545
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05603142
46Renal cell carcinoma_Homo sapiens_hsa052111.03620661
47Glioma_Homo sapiens_hsa052141.03388405
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.99694472
49Endocytosis_Homo sapiens_hsa041440.99000309
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98709187
51Dorso-ventral axis formation_Homo sapiens_hsa043200.98137798
52Arginine biosynthesis_Homo sapiens_hsa002200.98135777
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97490924
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93702588
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93461192
56Melanogenesis_Homo sapiens_hsa049160.93034659
57Lysosome_Homo sapiens_hsa041420.92331812
58Arginine and proline metabolism_Homo sapiens_hsa003300.91713164
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91462695
60Ether lipid metabolism_Homo sapiens_hsa005650.88937806
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.88371088
62Histidine metabolism_Homo sapiens_hsa003400.88194106
63Type II diabetes mellitus_Homo sapiens_hsa049300.85452592
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84906657
65Pancreatic secretion_Homo sapiens_hsa049720.84468299
66Steroid biosynthesis_Homo sapiens_hsa001000.84146278
67VEGF signaling pathway_Homo sapiens_hsa043700.79318734
68Cardiac muscle contraction_Homo sapiens_hsa042600.78084896
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77165721
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76913721
71Ras signaling pathway_Homo sapiens_hsa040140.76399801
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76151046
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75885221
74Biosynthesis of amino acids_Homo sapiens_hsa012300.75728169
75MAPK signaling pathway_Homo sapiens_hsa040100.75001535
76Other glycan degradation_Homo sapiens_hsa005110.73965276
77Rheumatoid arthritis_Homo sapiens_hsa053230.72919779
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72437636
79Alcoholism_Homo sapiens_hsa050340.70873720
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.69348437
81Choline metabolism in cancer_Homo sapiens_hsa052310.69298008
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.67802265
83Chemokine signaling pathway_Homo sapiens_hsa040620.67697588
84Dilated cardiomyopathy_Homo sapiens_hsa054140.67697527
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66533072
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.65383110
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64906916
88Thyroid hormone synthesis_Homo sapiens_hsa049180.62676889
89Phagosome_Homo sapiens_hsa041450.62669749
90Prion diseases_Homo sapiens_hsa050200.62519574
91Phenylalanine metabolism_Homo sapiens_hsa003600.61876473
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61764902
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61158862
94Insulin signaling pathway_Homo sapiens_hsa049100.60161664
95Glucagon signaling pathway_Homo sapiens_hsa049220.59568125
96Rap1 signaling pathway_Homo sapiens_hsa040150.59464153
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56475714
98Oocyte meiosis_Homo sapiens_hsa041140.55468909
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55436326
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55064173
101Salmonella infection_Homo sapiens_hsa051320.54391713
102Fructose and mannose metabolism_Homo sapiens_hsa000510.53466049
103Notch signaling pathway_Homo sapiens_hsa043300.52551284
104Sphingolipid metabolism_Homo sapiens_hsa006000.51871261
105Nitrogen metabolism_Homo sapiens_hsa009100.51811071
106Phototransduction_Homo sapiens_hsa047440.51075615
107Tight junction_Homo sapiens_hsa045300.50207676
108Endometrial cancer_Homo sapiens_hsa052130.49800469
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46818044
110Non-small cell lung cancer_Homo sapiens_hsa052230.46074045
111Inositol phosphate metabolism_Homo sapiens_hsa005620.46021761
112AMPK signaling pathway_Homo sapiens_hsa041520.45575590
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43749955
114mTOR signaling pathway_Homo sapiens_hsa041500.42068981
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41821718
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41378341
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40266346
118Pentose phosphate pathway_Homo sapiens_hsa000300.40233989
119Type I diabetes mellitus_Homo sapiens_hsa049400.40019706
120Fatty acid elongation_Homo sapiens_hsa000620.39863299
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39335402
122Ovarian steroidogenesis_Homo sapiens_hsa049130.38871733
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38788477
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38394272
125Alzheimers disease_Homo sapiens_hsa050100.37092032
126HIF-1 signaling pathway_Homo sapiens_hsa040660.36972326
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36182296
128Amoebiasis_Homo sapiens_hsa051460.35331504
129Carbon metabolism_Homo sapiens_hsa012000.35269666
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35204467
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34968499
132Wnt signaling pathway_Homo sapiens_hsa043100.34725529

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