IGSF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.07600838
2sperm motility (GO:0030317)5.81646836
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.76161518
4fusion of sperm to egg plasma membrane (GO:0007342)4.67565297
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.55202623
6hemidesmosome assembly (GO:0031581)4.54601983
7microtubule depolymerization (GO:0007019)4.53011816
8sperm capacitation (GO:0048240)4.50763556
9paraxial mesoderm development (GO:0048339)4.43161182
10chromosome condensation (GO:0030261)4.31246979
11intestinal absorption (GO:0050892)4.24574563
12spermatid development (GO:0007286)4.22242102
13single strand break repair (GO:0000012)4.17889003
14DNA packaging (GO:0006323)4.11380004
15establishment of tissue polarity (GO:0007164)4.11343185
16establishment of planar polarity (GO:0001736)4.11343185
17desmosome organization (GO:0002934)4.09551011
18spermatid nucleus differentiation (GO:0007289)3.98990366
19bundle of His cell to Purkinje myocyte communication (GO:0086069)3.82984892
20microtubule severing (GO:0051013)3.76970280
21protein polyglutamylation (GO:0018095)3.73825698
22nucleosome disassembly (GO:0006337)3.71545919
23protein-DNA complex disassembly (GO:0032986)3.71545919
24microtubule polymerization or depolymerization (GO:0031109)3.71311391
25regulation of gene silencing by RNA (GO:0060966)3.68278689
26regulation of posttranscriptional gene silencing (GO:0060147)3.68278689
27regulation of gene silencing by miRNA (GO:0060964)3.68278689
28establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.65373567
29lateral sprouting from an epithelium (GO:0060601)3.61594959
30positive regulation of gastrulation (GO:2000543)3.59135441
31vitamin A metabolic process (GO:0006776)3.55878811
32G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.52785399
33intestinal epithelial cell development (GO:0060576)3.51933334
34sperm-egg recognition (GO:0035036)3.51917335
35negative regulation of cell fate specification (GO:0009996)3.46030878
36epithelial structure maintenance (GO:0010669)3.41567164
37regulation of hippo signaling (GO:0035330)3.41157463
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38842257
39calcium ion-dependent exocytosis (GO:0017156)3.37921999
40regulation of water loss via skin (GO:0033561)3.37840925
41negative regulation of axon extension involved in axon guidance (GO:0048843)3.37823628
42pre-miRNA processing (GO:0031054)3.37593322
43negative regulation of keratinocyte proliferation (GO:0010839)3.37424516
44axonemal dynein complex assembly (GO:0070286)3.37392511
45multicellular organism reproduction (GO:0032504)3.35856448
46trophectodermal cell differentiation (GO:0001829)3.34849452
47head development (GO:0060322)3.34003512
48plasma membrane fusion (GO:0045026)3.33587659
49embryonic foregut morphogenesis (GO:0048617)3.31391783
50intestinal cholesterol absorption (GO:0030299)3.30745189
51pyrimidine nucleobase catabolic process (GO:0006208)3.30663244
52response to pheromone (GO:0019236)3.30539474
53cranial nerve morphogenesis (GO:0021602)3.29222516
54dosage compensation (GO:0007549)3.29009216
55ectoderm development (GO:0007398)3.25964691
56binding of sperm to zona pellucida (GO:0007339)3.25923855
57phosphatidylethanolamine biosynthetic process (GO:0006646)3.25670229
58dorsal/ventral axis specification (GO:0009950)3.22373394
59chromatin silencing (GO:0006342)3.18099323
60gastrulation with mouth forming second (GO:0001702)3.17225356
61outer ear morphogenesis (GO:0042473)3.16974751
62reproduction (GO:0000003)3.16570095
63establishment or maintenance of bipolar cell polarity (GO:0061245)3.16222370
64establishment or maintenance of apical/basal cell polarity (GO:0035088)3.16222370
65sexual reproduction (GO:0019953)3.12711324
66nucleobase catabolic process (GO:0046113)3.10906207
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09919841
68negative regulation of translation, ncRNA-mediated (GO:0040033)3.09919841
69regulation of translation, ncRNA-mediated (GO:0045974)3.09919841
70phosphatidylethanolamine metabolic process (GO:0046337)3.09415699
71regulation of somitogenesis (GO:0014807)3.08451513
72spermatogenesis (GO:0007283)3.08219165
73negative regulation of RNA splicing (GO:0033119)3.07502275
74male gamete generation (GO:0048232)3.06992161
75embryonic camera-type eye development (GO:0031076)3.06568883
76non-canonical Wnt signaling pathway (GO:0035567)3.06263144
77negative regulation of axon guidance (GO:1902668)3.06055384
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.06016624
79negative regulation of catenin import into nucleus (GO:0035414)3.03190505
80establishment of skin barrier (GO:0061436)3.03128433
81hippo signaling (GO:0035329)3.01014868
82regulation of establishment of planar polarity (GO:0090175)3.00656640
83eyelid development in camera-type eye (GO:0061029)3.00491417
84negative regulation of mRNA processing (GO:0050686)2.99681958
85lung-associated mesenchyme development (GO:0060484)2.96593027
86cellular ketone body metabolic process (GO:0046950)2.95829148
87interferon-gamma secretion (GO:0072643)2.95551837
88proximal/distal pattern formation (GO:0009954)2.93463945
89polarized epithelial cell differentiation (GO:0030859)2.92932181
90convergent extension (GO:0060026)2.92175420
91regulation of transforming growth factor beta2 production (GO:0032909)2.91922812
92epithelial cell-cell adhesion (GO:0090136)2.91860637
93endothelial cell chemotaxis (GO:0035767)2.90172978
94cell-cell recognition (GO:0009988)2.88456087
95negative regulation of cell fate commitment (GO:0010454)2.88246650
96glial cell proliferation (GO:0014009)2.87898867
97neuronal ion channel clustering (GO:0045161)2.86090781
98cochlea morphogenesis (GO:0090103)2.84172418
99regulation of cilium movement (GO:0003352)2.83931070
100gamete generation (GO:0007276)2.83538696
101regulation of chromatin binding (GO:0035561)2.79595820
102regulation of NFAT protein import into nucleus (GO:0051532)2.78631705
103epidermal cell differentiation (GO:0009913)2.78578413
104hair cell differentiation (GO:0035315)2.77440253
105establishment of epithelial cell polarity (GO:0090162)2.77104928
106notochord development (GO:0030903)2.75737652
107urogenital system development (GO:0001655)2.75564713
108mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74125259
109respiratory tube development (GO:0030323)2.73515895
110lens fiber cell development (GO:0070307)2.72071648
111positive regulation of Rab GTPase activity (GO:0032851)2.71700367
112regulation of Rab GTPase activity (GO:0032313)2.71700367
113lung epithelium development (GO:0060428)2.70236279
114cilium or flagellum-dependent cell motility (GO:0001539)2.69725134
115kidney morphogenesis (GO:0060993)2.68569173
116establishment of protein localization to Golgi (GO:0072600)2.68140223
117dopaminergic neuron differentiation (GO:0071542)2.67416720
118establishment of apical/basal cell polarity (GO:0035089)2.67346499
119renal system development (GO:0072001)2.66528257
120establishment of monopolar cell polarity (GO:0061162)2.66438505
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.66438505
122cell surface receptor signaling pathway involved in heart development (GO:0061311)2.66164216
123angiotensin maturation (GO:0002003)2.66039298
124post-anal tail morphogenesis (GO:0036342)2.65038994
125maintenance of gastrointestinal epithelium (GO:0030277)2.63623842
126face development (GO:0060324)2.62829757
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.62557841
128axon extension involved in axon guidance (GO:0048846)2.62557841
129regulation of gastrulation (GO:0010470)2.60956391
130regulation of guanylate cyclase activity (GO:0031282)2.60286271
131keratinization (GO:0031424)2.59741157
132cell-cell junction maintenance (GO:0045217)2.58760230
133collecting duct development (GO:0072044)2.58535107
134peptidyl-arginine omega-N-methylation (GO:0035247)2.57302697
135hindlimb morphogenesis (GO:0035137)2.54339217
136semaphorin-plexin signaling pathway (GO:0071526)2.54322966
137centriole replication (GO:0007099)2.54171613
138cellular response to pH (GO:0071467)2.53222262
139peptidyl-arginine N-methylation (GO:0035246)2.52415410
140peptidyl-arginine methylation (GO:0018216)2.52415410
141regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.51890244
142protein targeting to Golgi (GO:0000042)2.51814900
143regulation of cell fate specification (GO:0042659)2.51643148
144ketone body metabolic process (GO:1902224)2.50921954
145keratinocyte differentiation (GO:0030216)2.50530848
146lens morphogenesis in camera-type eye (GO:0002089)2.50474734
147germ cell development (GO:0007281)2.50066011
148hair cycle (GO:0042633)2.49682503
149molting cycle (GO:0042303)2.49682503
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49484942
151cell migration in hindbrain (GO:0021535)2.49261630
152regulation of cardioblast proliferation (GO:0003264)2.49248654
153axonal fasciculation (GO:0007413)2.49050062
154epithelial cilium movement (GO:0003351)2.48447178
155cilium movement (GO:0003341)2.48045380
156histone H3-K9 methylation (GO:0051567)2.47990961
157regulation of ruffle assembly (GO:1900027)2.47513063
158motile cilium assembly (GO:0044458)2.45232170
159response to misfolded protein (GO:0051788)2.44347739
160negative regulation of gene expression, epigenetic (GO:0045814)2.43378478
161dendritic spine organization (GO:0097061)2.42571167
162rRNA methylation (GO:0031167)2.42428523
163single fertilization (GO:0007338)2.38412645
164nonmotile primary cilium assembly (GO:0035058)2.38041180
165retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37549244
166somite rostral/caudal axis specification (GO:0032525)2.37167092
167regulation of neuron migration (GO:2001222)2.36332513
168negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.35194135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.46846074
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.99340385
3TP63_19390658_ChIP-ChIP_HaCaT_Human2.98251312
4* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.93013378
5DROSHA_22980978_ChIP-Seq_HELA_Human2.78435749
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62979536
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50084566
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.48801467
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38409539
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24445001
11* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22916189
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.19145052
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.03220761
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02033970
15TP63_17297297_ChIP-ChIP_HaCaT_Human10.1145268
16E2F7_22180533_ChIP-Seq_HELA_Human1.93296558
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90994553
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83683656
19TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83649899
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83124430
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.82084526
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81485176
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76484998
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76484998
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76484998
26* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73825317
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69943198
28* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67710183
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67579988
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65510326
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.65084694
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64717928
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64717928
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63081525
35SMC4_20622854_ChIP-Seq_HELA_Human1.59155566
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.58482063
37P68_20966046_ChIP-Seq_HELA_Human1.57120238
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56733911
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54219807
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53519051
41* GATA6_25053715_ChIP-Seq_YYC3_Human1.53314208
42KDM2B_26808549_Chip-Seq_K562_Human1.50728786
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.49709376
44* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.49355105
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49216640
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48449608
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.47584975
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47542976
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44855353
50* TP63_22573176_ChIP-Seq_HFKS_Human1.43800814
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.43636349
52REST_21632747_ChIP-Seq_MESCs_Mouse1.43008570
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42201149
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42084424
55ERA_21632823_ChIP-Seq_H3396_Human1.41011575
56E2F1_20622854_ChIP-Seq_HELA_Human1.39195303
57PHF8_20622854_ChIP-Seq_HELA_Human1.38686506
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38576276
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37226408
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34148226
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33042470
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.31647775
63ZNF263_19887448_ChIP-Seq_K562_Human1.31148402
64CREB1_26743006_Chip-Seq_LNCaP_Human1.31100548
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.30345398
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.29987469
67* KLF5_25053715_ChIP-Seq_YYC3_Human1.29502767
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29359814
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28999147
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28573190
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28160910
72RACK7_27058665_Chip-Seq_MCF-7_Human1.28056192
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27464753
74TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27143897
75VDR_22108803_ChIP-Seq_LS180_Human1.26275819
76* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26133796
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25962830
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.25875756
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.25518074
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24866145
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.24380203
82BCL6_27268052_Chip-Seq_Bcells_Human1.24271421
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23738270
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23375773
85CTCF_20526341_ChIP-Seq_ESCs_Human1.22558690
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22037477
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21556277
88BCOR_27268052_Chip-Seq_Bcells_Human1.18646052
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18548483
90* SA1_27219007_Chip-Seq_Bcells_Human1.18462841
91* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18391704
92* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17419134
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17287395
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.17102172
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16608735
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16541873
97* SA1_27219007_Chip-Seq_ERYTHROID_Human1.15760725
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15385769
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15344440
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15175383
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15024927
102POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14926721
103MYC_22102868_ChIP-Seq_BL_Human1.12694936
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.12435936
105FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12276470
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12245679
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11689510
108ZNF274_21170338_ChIP-Seq_K562_Hela1.11033615
109* LXR_22292898_ChIP-Seq_THP-1_Human1.10152795
110NANOG_20526341_ChIP-Seq_ESCs_Human1.09430163
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09220843
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09220843
113EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08845092
114* CTCF_27219007_Chip-Seq_Bcells_Human1.07902083
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07769184
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07749906
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07740627
118REST_18959480_ChIP-ChIP_MESCs_Mouse1.06599942
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.06544645
120OCT4_20526341_ChIP-Seq_ESCs_Human1.05738308
121ATF3_27146783_Chip-Seq_COLON_Human1.05660895
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05478961
123GATA4_25053715_ChIP-Seq_YYC3_Human1.04694814
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04254121
125P53_21459846_ChIP-Seq_SAOS-2_Human1.04128316
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03281869
127SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02575936
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02373419
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.02170404
130RAC3_21632823_ChIP-Seq_H3396_Human1.02148334
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.01789468
132DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01664730
133OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01022644
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00814546
135MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00764864
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00672567
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00316318
138* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00162115
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99980010
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.99447641
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99254311
142* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98724667
143SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98614111
144TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98578143
145OCT4_19829295_ChIP-Seq_ESCs_Human0.98477010
146GATA1_26923725_Chip-Seq_HPCs_Mouse0.98153884
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97908070
148* KDM2B_26808549_Chip-Seq_DND41_Human0.97821438
149AHR_22903824_ChIP-Seq_MCF-7_Human0.96767785
150EED_16625203_ChIP-ChIP_MESCs_Mouse0.96371218
151EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95960445
152RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95960445
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95828260
154MYC_19829295_ChIP-Seq_ESCs_Human0.95386684
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93447397
156TAF2_19829295_ChIP-Seq_ESCs_Human0.92977907
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.90901425
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.90071111
159* TET1_21490601_ChIP-Seq_MESCs_Mouse0.89766442
160P300_27268052_Chip-Seq_Bcells_Human0.86596065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.92479636
2MP0005410_abnormal_fertilization3.81927977
3MP0010030_abnormal_orbit_morphology3.65052749
4MP0010234_abnormal_vibrissa_follicle3.47522369
5MP0002653_abnormal_ependyma_morphology3.16275428
6MP0002822_catalepsy2.72701494
7MP0000566_synostosis2.71904093
8MP0003941_abnormal_skin_development2.58030659
9MP0009053_abnormal_anal_canal2.47217638
10MP0010352_gastrointestinal_tract_polyps2.45484039
11MP0005670_abnormal_white_adipose2.37423786
12MP0001849_ear_inflammation2.33989611
13MP0004264_abnormal_extraembryonic_tissu2.31189407
14MP0008789_abnormal_olfactory_epithelium2.25769958
15MP0003119_abnormal_digestive_system2.21720053
16MP0005076_abnormal_cell_differentiation2.20157333
17MP0000462_abnormal_digestive_system2.19380993
18MP0002796_impaired_skin_barrier2.12196769
19MP0006292_abnormal_olfactory_placode2.05585167
20MP0005377_hearing/vestibular/ear_phenot2.05582075
21MP0003878_abnormal_ear_physiology2.05582075
22MP0003890_abnormal_embryonic-extraembry1.99288531
23MP0002098_abnormal_vibrissa_morphology1.96706957
24MP0003705_abnormal_hypodermis_morpholog1.93384334
25MP0000579_abnormal_nail_morphology1.91773503
26MP0001346_abnormal_lacrimal_gland1.88426756
27MP0002234_abnormal_pharynx_morphology1.88308103
28MP0003315_abnormal_perineum_morphology1.87593759
29MP0003698_abnormal_male_reproductive1.85650972
30MP0002697_abnormal_eye_size1.83576483
31MP0003693_abnormal_embryo_hatching1.79831533
32MP0001188_hyperpigmentation1.75117888
33MP0005394_taste/olfaction_phenotype1.74147265
34MP0005499_abnormal_olfactory_system1.74147265
35MP0000049_abnormal_middle_ear1.72759624
36MP0001485_abnormal_pinna_reflex1.72405999
37MP0003283_abnormal_digestive_organ1.72130598
38MP0003122_maternal_imprinting1.70794404
39MP0002254_reproductive_system_inflammat1.67537381
40MP0003385_abnormal_body_wall1.62724461
41MP0010678_abnormal_skin_adnexa1.55343247
42MP0003937_abnormal_limbs/digits/tail_de1.54361911
43MP0005501_abnormal_skin_physiology1.53725576
44MP0002249_abnormal_larynx_morphology1.52927616
45MP0000762_abnormal_tongue_morphology1.52194988
46MP0000467_abnormal_esophagus_morphology1.50841785
47MP0000778_abnormal_nervous_system1.48728587
48MP0000534_abnormal_ureter_morphology1.47693009
49MP0005248_abnormal_Harderian_gland1.45676834
50MP0002233_abnormal_nose_morphology1.43221345
51MP0001929_abnormal_gametogenesis1.42813245
52MP0006276_abnormal_autonomic_nervous1.41622486
53MP0003121_genomic_imprinting1.41619801
54MP0003011_delayed_dark_adaptation1.40329074
55MP0001286_abnormal_eye_development1.35056475
56MP0000516_abnormal_urinary_system1.34750725
57MP0005367_renal/urinary_system_phenotyp1.34750725
58MP0000383_abnormal_hair_follicle1.34262191
59MP0000538_abnormal_urinary_bladder1.34253839
60MP0003718_maternal_effect1.34156100
61MP0003942_abnormal_urinary_system1.34094159
62MP0003115_abnormal_respiratory_system1.32480756
63MP0005187_abnormal_penis_morphology1.30677447
64MP0001666_abnormal_nutrient_absorption1.29954952
65MP0003755_abnormal_palate_morphology1.29708029
66MP0001348_abnormal_lacrimal_gland1.28941591
67MP0003861_abnormal_nervous_system1.27579946
68MP0003938_abnormal_ear_development1.22989032
69MP0000678_abnormal_parathyroid_gland1.22325625
70MP0002111_abnormal_tail_morphology1.22257917
71MP0001216_abnormal_epidermal_layer1.21719257
72MP0005423_abnormal_somatic_nervous1.21333909
73MP0002085_abnormal_embryonic_tissue1.20854764
74MP0003880_abnormal_central_pattern1.17987023
75MP0003123_paternal_imprinting1.17668818
76MP0002932_abnormal_joint_morphology1.16977643
77MP0002116_abnormal_craniofacial_bone1.16587098
78MP0002084_abnormal_developmental_patter1.16449779
79MP0002282_abnormal_trachea_morphology1.14411887
80MP0001293_anophthalmia1.11785924
81MP0002092_abnormal_eye_morphology1.10181576
82MP0002161_abnormal_fertility/fecundity1.07721757
83MP0004957_abnormal_blastocyst_morpholog1.06746916
84MP0000477_abnormal_intestine_morphology1.06399638
85MP0005645_abnormal_hypothalamus_physiol1.03497055
86MP0000428_abnormal_craniofacial_morphol1.03040446
87MP0002557_abnormal_social/conspecific_i1.02808085
88MP0000432_abnormal_head_morphology1.02490188
89MP0002735_abnormal_chemical_nociception1.01213667
90MP0001730_embryonic_growth_arrest1.00303938
91MP0003935_abnormal_craniofacial_develop1.00241026
92MP0002751_abnormal_autonomic_nervous1.00183664
93MP0001486_abnormal_startle_reflex0.99842737
94MP0003111_abnormal_nucleus_morphology0.99659035
95MP0002184_abnormal_innervation0.98396702
96MP0000955_abnormal_spinal_cord0.98204432
97MP0005083_abnormal_biliary_tract0.96435170
98MP0004197_abnormal_fetal_growth/weight/0.95372710
99MP0000470_abnormal_stomach_morphology0.95312369
100MP0002752_abnormal_somatic_nervous0.94778387
101MP0004742_abnormal_vestibular_system0.94567714
102MP0008995_early_reproductive_senescence0.94351402
103MP0001529_abnormal_vocalization0.94305380
104MP0005391_vision/eye_phenotype0.93087153
105MP0002210_abnormal_sex_determination0.92559973
106MP0006072_abnormal_retinal_apoptosis0.91168010
107MP0005409_darkened_coat_color0.90583593
108MP0000377_abnormal_hair_follicle0.90554552
109MP0000647_abnormal_sebaceous_gland0.89820137
110MP0000569_abnormal_digit_pigmentation0.89754443
111MP0002938_white_spotting0.89594674
112MP0004885_abnormal_endolymph0.88329039
113MP0005551_abnormal_eye_electrophysiolog0.87914762
114MP0001340_abnormal_eyelid_morphology0.87813736
115MP0005253_abnormal_eye_physiology0.86487977
116MP0000026_abnormal_inner_ear0.86239375
117MP0000350_abnormal_cell_proliferation0.86015584
118MP0005380_embryogenesis_phenotype0.85276580
119MP0001672_abnormal_embryogenesis/_devel0.85276580
120MP0002089_abnormal_postnatal_growth/wei0.85262783
121MP0005275_abnormal_skin_tensile0.84398117
122MP0004270_analgesia0.83555047
123MP0000490_abnormal_crypts_of0.83175384
124MP0002177_abnormal_outer_ear0.82989515
125MP0002060_abnormal_skin_morphology0.81661123
126MP0001963_abnormal_hearing_physiology0.81603763
127MP0009250_abnormal_appendicular_skeleto0.81579493
128MP0002277_abnormal_respiratory_mucosa0.81395367
129MP0001765_abnormal_ion_homeostasis0.81000088
130MP0004133_heterotaxia0.80958959
131MP0002734_abnormal_mechanical_nocicepti0.80557470
132MP0000631_abnormal_neuroendocrine_gland0.80313185
133MP0005381_digestive/alimentary_phenotyp0.79166007
134MP0008932_abnormal_embryonic_tissue0.79070359
135MP0000427_abnormal_hair_cycle0.78978132
136MP0004782_abnormal_surfactant_physiolog0.76487566
137MP0002882_abnormal_neuron_morphology0.76259422
138MP0005360_urolithiasis0.76219464
139MP0000653_abnormal_sex_gland0.76104701
140MP0001984_abnormal_olfaction0.76013207
141MP0001145_abnormal_male_reproductive0.75647911
142MP0004019_abnormal_vitamin_homeostasis0.74198607

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)4.24298190
2Short 4th metacarpal (HP:0010044)3.91618993
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.91618993
4Genetic anticipation (HP:0003743)3.88180933
5Fragile nails (HP:0001808)3.56761917
6Severe visual impairment (HP:0001141)3.38191910
7Hypoplastic ischia (HP:0003175)3.35101324
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.33697637
9Right ventricular cardiomyopathy (HP:0011663)3.22934513
10Renal duplication (HP:0000075)3.17588768
11Pili torti (HP:0003777)3.08213253
12Hyperacusis (HP:0010780)3.03309907
13Down-sloping shoulders (HP:0200021)3.02979987
14Tubulointerstitial nephritis (HP:0001970)3.00173750
15Woolly hair (HP:0002224)2.93846655
16Progressive cerebellar ataxia (HP:0002073)2.90598142
17Bony spicule pigmentary retinopathy (HP:0007737)2.84415810
18Esophageal atresia (HP:0002032)2.83291957
19Abnormality of the ischium (HP:0003174)2.81061423
20Chronic hepatic failure (HP:0100626)2.75657241
21Atrophic scars (HP:0001075)2.72271181
22Short phalanx of the thumb (HP:0009660)2.71301621
23Abnormality of the 4th metacarpal (HP:0010012)2.70681427
24Abnormality of the distal phalanx of the thumb (HP:0009617)2.66310581
25Plantar hyperkeratosis (HP:0007556)2.66067570
26Bell-shaped thorax (HP:0001591)2.64765463
27Renal dysplasia (HP:0000110)2.63191337
28Abnormality of the gastric mucosa (HP:0004295)2.62678279
29Elfin facies (HP:0004428)2.57854145
30Amelogenesis imperfecta (HP:0000705)2.52063065
31Onycholysis (HP:0001806)2.50614074
32Abnormality of the pubic bones (HP:0003172)2.49612339
33Absent/shortened dynein arms (HP:0200106)2.46640054
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.46640054
35Abnormality of the parathyroid morphology (HP:0011766)2.40527130
36Impulsivity (HP:0100710)2.37656407
37Nephronophthisis (HP:0000090)2.35817379
38Flattened epiphyses (HP:0003071)2.34869399
39Renovascular hypertension (HP:0100817)2.33229350
40Retinal dysplasia (HP:0007973)2.31318649
41Neoplasm of the heart (HP:0100544)2.28215496
42Hypoplastic labia majora (HP:0000059)2.25858097
43Abnormality of nail color (HP:0100643)2.25660710
44Hyperkalemia (HP:0002153)2.23375476
45Ankyloglossia (HP:0010296)2.21111406
46Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.19902002
47Aplasia cutis congenita (HP:0001057)2.19232040
48Ridged nail (HP:0001807)2.17260326
49Overriding aorta (HP:0002623)2.15962500
50Medulloblastoma (HP:0002885)2.14777756
51Pendular nystagmus (HP:0012043)2.14184552
52Hyperactive renin-angiotensin system (HP:0000841)2.13672085
53Oligodactyly (HP:0012165)2.13393390
54Morphological abnormality of the middle ear (HP:0008609)2.13080882
55Abnormality of the 1st metacarpal (HP:0010009)2.12307828
56Pigmentary retinal degeneration (HP:0001146)2.11702936
57High anterior hairline (HP:0009890)2.11339915
58Abnormality of the labia majora (HP:0012881)2.10274700
59Chronic bronchitis (HP:0004469)2.08571807
60Abnormal respiratory motile cilium morphology (HP:0005938)2.07897152
61Abnormal respiratory epithelium morphology (HP:0012253)2.07897152
62Nuclear cataract (HP:0100018)2.07442848
63Abnormality of the renal medulla (HP:0100957)2.06461216
64Anal stenosis (HP:0002025)2.05799919
65Anophthalmia (HP:0000528)2.03889006
66Abnormality of the aortic arch (HP:0012303)2.03700264
67Abnormality of macular pigmentation (HP:0008002)2.03425530
68Ependymoma (HP:0002888)2.02519437
69Spina bifida occulta (HP:0003298)2.01928175
70Midline defect of the nose (HP:0004122)2.01524424
71Curly hair (HP:0002212)2.01518132
72Depressed nasal tip (HP:0000437)1.99505209
73Increased nuchal translucency (HP:0010880)1.99482929
74Natal tooth (HP:0000695)1.99383971
75Abnormal ciliary motility (HP:0012262)1.99363922
76Gastrointestinal atresia (HP:0002589)1.99318245
77Selective tooth agenesis (HP:0001592)1.99215978
78Labial hypoplasia (HP:0000066)1.98280369
79Lip pit (HP:0100267)1.98266406
80Bilateral microphthalmos (HP:0007633)1.97523277
81Flat capital femoral epiphysis (HP:0003370)1.97454113
82Attenuation of retinal blood vessels (HP:0007843)1.97415441
83Chorioretinal atrophy (HP:0000533)1.95034452
84Zonular cataract (HP:0010920)1.94913510
85Abnormal hair laboratory examination (HP:0003328)1.94657807
86Abnormal respiratory motile cilium physiology (HP:0012261)1.94454963
87Shawl scrotum (HP:0000049)1.93511149
88Flat cornea (HP:0007720)1.92770946
89Bronchomalacia (HP:0002780)1.90973337
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90962661
91Anterior segment dysgenesis (HP:0007700)1.90438649
92Enlarged epiphyses (HP:0010580)1.89180208
93Myokymia (HP:0002411)1.88978932
94Slow-growing hair (HP:0002217)1.88811034
95Abnormality of hair growth rate (HP:0011363)1.88811034
96Gastrointestinal carcinoma (HP:0002672)1.88765005
97Malignant gastrointestinal tract tumors (HP:0006749)1.88765005
98Severe Myopia (HP:0011003)1.88134045
99Anonychia (HP:0001798)1.86901428
100Wide cranial sutures (HP:0010537)1.86879967
101Short 1st metacarpal (HP:0010034)1.86207110
102Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86207110
103Germ cell neoplasia (HP:0100728)1.86070418
104Abnormal number of incisors (HP:0011064)1.85655876
105Shallow orbits (HP:0000586)1.85402011
106Malnutrition (HP:0004395)1.84963637
107Hyperglycinuria (HP:0003108)1.84478195
108Progressive sensorineural hearing impairment (HP:0000408)1.83273965
109Sclerocornea (HP:0000647)1.81456075
110Advanced eruption of teeth (HP:0006288)1.80978829
111Abnormality of the intervertebral disk (HP:0005108)1.80515283
112Fragile skin (HP:0001030)1.80204160
113Abnormality of the labia minora (HP:0012880)1.80103114
114Sprengel anomaly (HP:0000912)1.79639391
115Hypoplastic female external genitalia (HP:0012815)1.78863462
116Unilateral renal agenesis (HP:0000122)1.78628833
117Cutaneous finger syndactyly (HP:0010554)1.77941967
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77316652
119Cystic liver disease (HP:0006706)1.77136781
120Infertility (HP:0000789)1.76521646
121Bicornuate uterus (HP:0000813)1.75931394
122Congenital stationary night blindness (HP:0007642)1.75801175
123Vitreoretinal degeneration (HP:0000655)1.74743406
124Insomnia (HP:0100785)1.74713343
125Trigonocephaly (HP:0000243)1.74591272
126Skull defect (HP:0001362)1.74504643
127Mixed hearing impairment (HP:0000410)1.74227121
128Nail dystrophy (HP:0008404)1.73732389
129Absent eyebrow (HP:0002223)1.73600323
130Absent epiphyses (HP:0010577)1.72967133
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72967133
132Decreased circulating renin level (HP:0003351)1.71823207
133Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.71534134
134Abnormality of abdominal situs (HP:0011620)1.71030862
135Abdominal situs inversus (HP:0003363)1.71030862
136Intestinal atresia (HP:0011100)1.71010933
137Patellar aplasia (HP:0006443)1.70826924
138Pterygium (HP:0001059)1.70671068
139Palmar hyperkeratosis (HP:0010765)1.70163258
140Aplasia/Hypoplasia of the patella (HP:0006498)1.70022771
141Uterine leiomyosarcoma (HP:0002891)1.69559485
142Leiomyosarcoma (HP:0100243)1.69559485
143Palmoplantar hyperkeratosis (HP:0000972)1.68572760
144Long palpebral fissure (HP:0000637)1.68444551
145Widely patent fontanelles and sutures (HP:0004492)1.68423634
146Male infertility (HP:0003251)1.68102292
147Abnormality of the parietal bone (HP:0002696)1.68041688
148Abnormality of the phalanges of the hallux (HP:0010057)1.66929136
149Ureteral stenosis (HP:0000071)1.66186913
150Optic nerve hypoplasia (HP:0000609)1.66135148
151Renal hypoplasia (HP:0000089)1.66084213
152Deviation of the thumb (HP:0009603)1.65734690
153Abnormality of the diencephalon (HP:0010662)1.65519365
154Patellar dislocation (HP:0002999)1.64628333
155Skin tags (HP:0010609)1.63818560
156Anencephaly (HP:0002323)1.63178948
157Tubular atrophy (HP:0000092)1.62567111
158Congenital malformation of the right heart (HP:0011723)1.61793390
159Double outlet right ventricle (HP:0001719)1.61793390
160Sparse scalp hair (HP:0002209)1.60584851
161Abnormality of the labia (HP:0000058)1.59492719
162Abnormality of the astrocytes (HP:0100707)1.59306235
163Astrocytoma (HP:0009592)1.59306235
164Stage 5 chronic kidney disease (HP:0003774)1.58293178
165Hypoplasia of dental enamel (HP:0006297)1.58208456
166Truncal obesity (HP:0001956)1.57401512
167Abnormality of permanent molar morphology (HP:0011071)1.54961115
168Taurodontia (HP:0000679)1.54961115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.70217922
2EPHA24.20178914
3INSRR3.99531019
4MAP3K103.86547768
5MAPK153.07589953
6PLK43.00905483
7MAP4K22.51484598
8BCR2.39595159
9CDK122.29956200
10SIK32.08850089
11MARK12.06729276
12CASK2.01813700
13DDR22.01372137
14ICK1.94794325
15TESK11.91404292
16LATS11.90485016
17PASK1.88293262
18PTK61.87710291
19BRD41.85846673
20MET1.85378559
21KSR11.83809022
22ERBB31.83191479
23MST41.81987989
24ERBB21.81832189
25FER1.81432744
26MAP2K21.75691779
27PDGFRA1.59847657
28PAK41.59732934
29PRKD31.59708888
30RIPK11.56959506
31MATK1.54289383
32PRKCI1.52561726
33RPS6KB21.51834382
34WNK31.50663176
35LMTK21.49618248
36DYRK21.49349992
37MST1R1.48893609
38EEF2K1.48814880
39PNCK1.48603740
40DYRK1B1.45321832
41CAMK1G1.39963525
42DYRK31.38007744
43FGFR11.30272343
44FGFR21.28034824
45NME11.25016400
46TYRO31.24595488
47IRAK21.22672341
48AKT31.19808821
49NEK21.02887369
50PTK21.02478048
51MAP3K91.01287508
52CAMK1D1.00266166
53STK380.94471446
54CDK190.90668993
55CDC70.89769135
56CDK70.89698190
57TTK0.89171046
58MKNK10.87688743
59TNK20.86594045
60CHUK0.85825247
61GRK10.83872699
62MTOR0.83700128
63TRIB30.80627122
64UHMK10.80248329
65NEK60.78524763
66LATS20.77957989
67SRPK10.77620097
68AKT20.76273331
69MUSK0.75983938
70ATR0.75285467
71MARK20.74112168
72LIMK10.73731164
73RPS6KA10.73695617
74RPS6KA20.72146953
75MINK10.71905615
76FGFR40.70907959
77CDK60.69645582
78MAP2K60.68796485
79TSSK60.68649996
80MAP3K40.67711706
81MAP3K80.66335429
82NEK10.65713485
83TGFBR10.64673207
84GRK60.63494086
85AURKB0.62849779
86MAP3K60.62363342
87NTRK20.62217716
88CHEK10.60171833
89MAPKAPK30.58249524
90TESK20.57753995
91TRIM280.57620636
92MAPK80.57533613
93RPS6KA60.57497729
94PRKCZ0.57413153
95NTRK30.56466400
96YES10.55691278
97RPS6KL10.55672930
98RPS6KC10.55672930
99MAP2K10.55447313
100SIK20.55246452
101MAP3K20.54971230
102EPHA40.54050490
103BMX0.53270457
104PAK30.52981270
105EPHA30.52727863
106ERN10.52665658
107CDK40.52364177
108GSK3B0.51718095
109WNK40.51010673
110NUAK10.50358204
111SIK10.50097951
112CDK30.49359995
113ROCK10.49097515
114MAPK90.48407808
115FRK0.47773169
116PRKAA10.47651498
117BMPR1B0.47054782
118CSNK1A10.46907959
119CHEK20.46818045
120MAPK130.46562051
121SMG10.46068592
122CDK20.45569896
123MELK0.44477169
124STK38L0.44469548
125SGK2230.43631758
126SGK4940.43631758
127TNIK0.43332351
128PRKG20.42432246
129CDC42BPA0.41663163
130DMPK0.40826082
131AURKA0.39578507
132CDK10.39394656
133PKN20.39381938
134PLK10.39285413
135PAK20.39218993
136CDK180.38886677
137CSNK1E0.38603438
138NTRK10.38356864
139PAK10.38260949
140PLK30.37309545
141ALK0.37061037
142STK390.36989507
143AKT10.36983499
144ACVR1B0.36786764
145MAP2K70.34430073
146MAPK10.32773966
147OXSR10.32706288
148MAP3K70.32030089

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.16843506
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.14094800
3Fat digestion and absorption_Homo sapiens_hsa049753.01893138
4Hedgehog signaling pathway_Homo sapiens_hsa043402.94448321
5Hippo signaling pathway_Homo sapiens_hsa043902.84466447
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72332255
7Fatty acid biosynthesis_Homo sapiens_hsa000612.48879655
8Phototransduction_Homo sapiens_hsa047442.40555658
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.28777838
10Notch signaling pathway_Homo sapiens_hsa043302.24342441
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.12141277
12Taste transduction_Homo sapiens_hsa047422.06314929
13Adherens junction_Homo sapiens_hsa045202.03360650
14Mineral absorption_Homo sapiens_hsa049782.00200154
15Renin-angiotensin system_Homo sapiens_hsa046141.94575949
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93516211
17Nicotine addiction_Homo sapiens_hsa050331.86599111
18Tight junction_Homo sapiens_hsa045301.86367733
19Axon guidance_Homo sapiens_hsa043601.81142733
20Protein digestion and absorption_Homo sapiens_hsa049741.77274956
21Butanoate metabolism_Homo sapiens_hsa006501.75531927
22Spliceosome_Homo sapiens_hsa030401.73234770
23Phenylalanine metabolism_Homo sapiens_hsa003601.68503175
24Arginine and proline metabolism_Homo sapiens_hsa003301.67772988
25Endometrial cancer_Homo sapiens_hsa052131.65466689
26Wnt signaling pathway_Homo sapiens_hsa043101.60647691
27Retinol metabolism_Homo sapiens_hsa008301.60217462
28Caffeine metabolism_Homo sapiens_hsa002321.55632661
29mRNA surveillance pathway_Homo sapiens_hsa030151.53673580
30Histidine metabolism_Homo sapiens_hsa003401.53357702
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.53014526
32ABC transporters_Homo sapiens_hsa020101.51222313
33Bladder cancer_Homo sapiens_hsa052191.46700533
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45947063
35MicroRNAs in cancer_Homo sapiens_hsa052061.45789627
36Colorectal cancer_Homo sapiens_hsa052101.34485200
37Melanogenesis_Homo sapiens_hsa049161.34423225
38Cocaine addiction_Homo sapiens_hsa050301.33893121
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33172024
40Proteoglycans in cancer_Homo sapiens_hsa052051.32902596
41Small cell lung cancer_Homo sapiens_hsa052221.27349691
42Vitamin digestion and absorption_Homo sapiens_hsa049771.22027043
43Olfactory transduction_Homo sapiens_hsa047401.18598754
44Bile secretion_Homo sapiens_hsa049761.18440865
45Fatty acid degradation_Homo sapiens_hsa000711.16510346
46Thyroid cancer_Homo sapiens_hsa052161.15649773
47Glycerolipid metabolism_Homo sapiens_hsa005611.14289532
48Fatty acid metabolism_Homo sapiens_hsa012121.14103175
49Pathways in cancer_Homo sapiens_hsa052001.13069506
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12741555
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12475340
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11564776
53Chronic myeloid leukemia_Homo sapiens_hsa052201.10922082
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.10857958
55Cell cycle_Homo sapiens_hsa041101.09184575
56Tyrosine metabolism_Homo sapiens_hsa003501.07814367
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07252016
58Viral myocarditis_Homo sapiens_hsa054161.06874724
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06866862
60Steroid biosynthesis_Homo sapiens_hsa001001.05733285
61Chemical carcinogenesis_Homo sapiens_hsa052041.03276802
62Tryptophan metabolism_Homo sapiens_hsa003801.02539817
63TGF-beta signaling pathway_Homo sapiens_hsa043501.00465598
64Serotonergic synapse_Homo sapiens_hsa047261.00303757
65HTLV-I infection_Homo sapiens_hsa051661.00078145
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99716352
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96554540
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.96417501
69Ether lipid metabolism_Homo sapiens_hsa005650.96162252
70Arginine biosynthesis_Homo sapiens_hsa002200.95044034
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94859261
72RNA transport_Homo sapiens_hsa030130.93486696
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92343421
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91502643
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91129338
76Glutamatergic synapse_Homo sapiens_hsa047240.86303109
77p53 signaling pathway_Homo sapiens_hsa041150.85558411
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84399869
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.84243774
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.81633085
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.80682352
82Fanconi anemia pathway_Homo sapiens_hsa034600.80081764
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78334076
84Salmonella infection_Homo sapiens_hsa051320.77479187
85DNA replication_Homo sapiens_hsa030300.77345255
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76670323
87Arachidonic acid metabolism_Homo sapiens_hsa005900.75974988
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75861251
89Insulin secretion_Homo sapiens_hsa049110.75063712
90Morphine addiction_Homo sapiens_hsa050320.74633715
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.73638412
92Dopaminergic synapse_Homo sapiens_hsa047280.73131562
93PPAR signaling pathway_Homo sapiens_hsa033200.72700773
94Fructose and mannose metabolism_Homo sapiens_hsa000510.71334956
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69232880
96Base excision repair_Homo sapiens_hsa034100.68279253
97Apoptosis_Homo sapiens_hsa042100.67530270
98Cholinergic synapse_Homo sapiens_hsa047250.67347620
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67049474
100Lysine degradation_Homo sapiens_hsa003100.66705886
101Circadian entrainment_Homo sapiens_hsa047130.66434579
102ErbB signaling pathway_Homo sapiens_hsa040120.65912476
103TNF signaling pathway_Homo sapiens_hsa046680.65365420
104Galactose metabolism_Homo sapiens_hsa000520.64740948
105GABAergic synapse_Homo sapiens_hsa047270.63982987
106Shigellosis_Homo sapiens_hsa051310.63792146
107Viral carcinogenesis_Homo sapiens_hsa052030.63569940
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.62550082
109Selenocompound metabolism_Homo sapiens_hsa004500.61900637
110Toxoplasmosis_Homo sapiens_hsa051450.61885118
111Estrogen signaling pathway_Homo sapiens_hsa049150.61695490
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60630102
113Sphingolipid metabolism_Homo sapiens_hsa006000.59586731
114Type II diabetes mellitus_Homo sapiens_hsa049300.58901853
115Non-small cell lung cancer_Homo sapiens_hsa052230.58550923
116Influenza A_Homo sapiens_hsa051640.57864093
117VEGF signaling pathway_Homo sapiens_hsa043700.57173119
118mTOR signaling pathway_Homo sapiens_hsa041500.56977219
119Melanoma_Homo sapiens_hsa052180.56692223
120Gap junction_Homo sapiens_hsa045400.55940561
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54753665
122Herpes simplex infection_Homo sapiens_hsa051680.54213355
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53577644
124Sulfur relay system_Homo sapiens_hsa041220.52930924
125ECM-receptor interaction_Homo sapiens_hsa045120.51963509
126AMPK signaling pathway_Homo sapiens_hsa041520.50335662
127Prostate cancer_Homo sapiens_hsa052150.50107194
128Alcoholism_Homo sapiens_hsa050340.49845799
129cAMP signaling pathway_Homo sapiens_hsa040240.49795803
130Mismatch repair_Homo sapiens_hsa034300.49109147
131Renal cell carcinoma_Homo sapiens_hsa052110.48672690
132Choline metabolism in cancer_Homo sapiens_hsa052310.48415489
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.48332688
134Nitrogen metabolism_Homo sapiens_hsa009100.47575323
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47414173
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45147477
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45052599
138Focal adhesion_Homo sapiens_hsa045100.44590249
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43725804
140Amphetamine addiction_Homo sapiens_hsa050310.43480488
141Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42513132
142Hepatitis C_Homo sapiens_hsa051600.42501198
143Biosynthesis of amino acids_Homo sapiens_hsa012300.42446213
144beta-Alanine metabolism_Homo sapiens_hsa004100.42355787
145Long-term depression_Homo sapiens_hsa047300.42200176
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41776139
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41747919
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41016747
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40960475
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39698317
151Epstein-Barr virus infection_Homo sapiens_hsa051690.39425588
152Legionellosis_Homo sapiens_hsa051340.39033396
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38243174
154Rap1 signaling pathway_Homo sapiens_hsa040150.38036411
155Salivary secretion_Homo sapiens_hsa049700.37619659
156Systemic lupus erythematosus_Homo sapiens_hsa053220.37344236
157Amoebiasis_Homo sapiens_hsa051460.37198202
158Pancreatic cancer_Homo sapiens_hsa052120.35959138
159Acute myeloid leukemia_Homo sapiens_hsa052210.34094347
160Linoleic acid metabolism_Homo sapiens_hsa005910.33468405
161Hepatitis B_Homo sapiens_hsa051610.33032592
162Leishmaniasis_Homo sapiens_hsa051400.30094572
163Oocyte meiosis_Homo sapiens_hsa041140.30018260
164Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29234793
165N-Glycan biosynthesis_Homo sapiens_hsa005100.29091415
166Inositol phosphate metabolism_Homo sapiens_hsa005620.27867566
167Insulin resistance_Homo sapiens_hsa049310.26821458

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