IGSF9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57548944
2synaptic vesicle maturation (GO:0016188)5.30450672
3locomotory exploration behavior (GO:0035641)5.23745300
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.19301788
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01594265
6vocalization behavior (GO:0071625)4.86953490
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.76068895
8synaptic vesicle exocytosis (GO:0016079)4.52234397
9response to pheromone (GO:0019236)4.50090732
10glutamate secretion (GO:0014047)4.28098766
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27985862
12layer formation in cerebral cortex (GO:0021819)4.27929999
13positive regulation of synapse maturation (GO:0090129)4.15718242
14regulation of synaptic vesicle exocytosis (GO:2000300)4.08860566
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05001666
16cellular potassium ion homeostasis (GO:0030007)4.04432728
17cerebellar Purkinje cell differentiation (GO:0021702)4.03411108
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.99640213
19dendritic spine morphogenesis (GO:0060997)3.94787374
20regulation of NFAT protein import into nucleus (GO:0051532)3.94379312
21* regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92400112
22regulation of glutamate receptor signaling pathway (GO:1900449)3.90760558
23neuronal action potential propagation (GO:0019227)3.89507154
24synaptic transmission, glutamatergic (GO:0035249)3.88759934
25establishment of nucleus localization (GO:0040023)3.87088844
26innervation (GO:0060384)3.84373769
27protein localization to synapse (GO:0035418)3.82940994
28neurotransmitter secretion (GO:0007269)3.81705606
29cell communication by electrical coupling (GO:0010644)3.79162274
30sodium ion export (GO:0071436)3.78041568
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73934372
32glutamate receptor signaling pathway (GO:0007215)3.73019995
33exploration behavior (GO:0035640)3.71646261
34regulation of synapse structural plasticity (GO:0051823)3.71598674
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70715181
36neuron cell-cell adhesion (GO:0007158)3.65261195
37neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.64714476
38cerebellar granule cell differentiation (GO:0021707)3.62197575
39regulation of neuronal synaptic plasticity (GO:0048168)3.59038114
40neuromuscular process controlling balance (GO:0050885)3.51952218
41neuron-neuron synaptic transmission (GO:0007270)3.48830047
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44272171
43proline transport (GO:0015824)3.42471036
44regulation of synaptic vesicle transport (GO:1902803)3.41500284
45gamma-aminobutyric acid transport (GO:0015812)3.40748354
46cell migration in hindbrain (GO:0021535)3.38693792
47long-term memory (GO:0007616)3.35275841
48positive regulation of membrane potential (GO:0045838)3.29572798
49neurotransmitter-gated ion channel clustering (GO:0072578)3.25613389
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23669826
51dendrite morphogenesis (GO:0048813)3.18604991
52axonal fasciculation (GO:0007413)3.16780176
53neural tube development (GO:0021915)3.15552013
54membrane depolarization during action potential (GO:0086010)3.15049075
55regulation of dendritic spine morphogenesis (GO:0061001)3.14973336
56synaptic vesicle endocytosis (GO:0048488)3.14089355
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.14016305
58prepulse inhibition (GO:0060134)3.10663697
59* regulation of postsynaptic membrane potential (GO:0060078)3.10042422
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09720964
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.09019847
62histone H3-K36 demethylation (GO:0070544)3.08360503
63cardiac myofibril assembly (GO:0055003)3.07196792
64auditory behavior (GO:0031223)3.05893919
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.05788410
66neuron recognition (GO:0008038)3.00867147
67presynaptic membrane assembly (GO:0097105)2.99569784
68neuromuscular process controlling posture (GO:0050884)2.98999600
69* membrane hyperpolarization (GO:0060081)2.98589697
70regulation of synapse maturation (GO:0090128)2.97828206
71cell differentiation in hindbrain (GO:0021533)2.97453086
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96952228
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.96533757
74dendritic spine organization (GO:0097061)2.96359714
75negative regulation of histone methylation (GO:0031061)2.93332257
76embryonic retina morphogenesis in camera-type eye (GO:0060059)2.92437019
77postsynaptic membrane organization (GO:0001941)2.91151737
78regulation of synaptic plasticity (GO:0048167)2.90970560
79negative regulation of myotube differentiation (GO:0010832)2.90622682
80cell communication involved in cardiac conduction (GO:0086065)2.90615451
81regulation of neurotransmitter secretion (GO:0046928)2.89331221
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89286245
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89177008
84adult heart development (GO:0007512)2.88022346
85neurotransmitter transport (GO:0006836)2.88017160
86activation of protein kinase A activity (GO:0034199)2.86873321
87synapse assembly (GO:0007416)2.86243088
88neuromuscular process (GO:0050905)2.85238197
89cardiac muscle hypertrophy (GO:0003300)2.84592449
90potassium ion homeostasis (GO:0055075)2.82812146
91chemosensory behavior (GO:0007635)2.82570014
92myelination in peripheral nervous system (GO:0022011)2.81993284
93peripheral nervous system axon ensheathment (GO:0032292)2.81993284
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.80676699
95transmission of nerve impulse (GO:0019226)2.79924837
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79823051
97pre-miRNA processing (GO:0031054)2.79429743
98membrane depolarization (GO:0051899)2.78391562
99response to auditory stimulus (GO:0010996)2.76102824
100negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.75347190
101cardiac muscle contraction (GO:0060048)2.74059172
102adherens junction assembly (GO:0034333)2.72677366
103cochlea development (GO:0090102)2.72355524
104regulation of actin filament-based movement (GO:1903115)2.70886948
105neuronal ion channel clustering (GO:0045161)2.70762548
106presynaptic membrane organization (GO:0097090)2.69122508
107synapse organization (GO:0050808)2.67905213
108regulation of neurotransmitter transport (GO:0051588)2.65742122
109striated muscle hypertrophy (GO:0014897)2.64995738
110regulation of neurotransmitter levels (GO:0001505)2.64955569
111vesicle transport along microtubule (GO:0047496)2.63445407
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63161203
113negative regulation of translation, ncRNA-mediated (GO:0040033)2.63161203
114regulation of translation, ncRNA-mediated (GO:0045974)2.63161203
115nucleus localization (GO:0051647)2.62794080
116semaphorin-plexin signaling pathway (GO:0071526)2.62789387
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62175007
118positive regulation of dendritic spine development (GO:0060999)2.61381531
119organelle transport along microtubule (GO:0072384)2.61082713
120long-term synaptic potentiation (GO:0060291)2.59066367
121cardiac muscle adaptation (GO:0014887)2.58955546
122cardiac muscle hypertrophy in response to stress (GO:0014898)2.58955546
123muscle hypertrophy in response to stress (GO:0003299)2.58955546
124central nervous system projection neuron axonogenesis (GO:0021952)2.58874602
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.58747125
126learning (GO:0007612)2.58170416
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58126050
128cell-substrate adherens junction assembly (GO:0007045)2.58120745
129focal adhesion assembly (GO:0048041)2.58120745
130myofibril assembly (GO:0030239)2.57399586
131histone H3-K9 demethylation (GO:0033169)2.57158771
132chromatin silencing (GO:0006342)2.55384262
133response to inactivity (GO:0014854)2.51909664
134paraxial mesoderm development (GO:0048339)2.51090380
135embryonic camera-type eye morphogenesis (GO:0048596)2.50726863
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50178569
137spinal cord development (GO:0021510)2.50107801
138regulation of gene silencing by RNA (GO:0060966)2.47826145
139regulation of posttranscriptional gene silencing (GO:0060147)2.47826145
140regulation of gene silencing by miRNA (GO:0060964)2.47826145
141positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.47234515
142apoptotic process involved in morphogenesis (GO:0060561)2.46071237
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45963106
144regulation of cardiac muscle cell contraction (GO:0086004)2.43796156
145sarcomere organization (GO:0045214)2.43752107
146histone lysine demethylation (GO:0070076)2.43513484
147enteric nervous system development (GO:0048484)2.41108193
148establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.40009302
149mitochondrion transport along microtubule (GO:0047497)2.40009302
150heart morphogenesis (GO:0003007)2.39803906
151adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.38970056
152dopamine receptor signaling pathway (GO:0007212)2.37782769
153coronary vasculature morphogenesis (GO:0060977)2.37356953
154cellular response to catecholamine stimulus (GO:0071870)2.34066713
155cellular response to monoamine stimulus (GO:0071868)2.34066713
156regulation of ARF protein signal transduction (GO:0032012)2.33971388
157amino acid import (GO:0043090)2.32596306
158positive regulation of gene expression, epigenetic (GO:0045815)2.32285994
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31923198
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.31539556
161L-amino acid import (GO:0043092)2.29773721
162ventricular trabecula myocardium morphogenesis (GO:0003222)2.29229250
163establishment of mitochondrion localization (GO:0051654)2.27705552
164histone H3-K4 methylation (GO:0051568)2.26587382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45080992
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.60588434
3GBX2_23144817_ChIP-Seq_PC3_Human3.21436625
4DROSHA_22980978_ChIP-Seq_HELA_Human2.81804203
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.74555493
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.55399287
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50066812
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.49521551
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44513551
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39793916
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39379120
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27364570
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19302494
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19302494
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17553474
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15559692
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10085184
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.04371011
19REST_18959480_ChIP-ChIP_MESCs_Mouse1.99531651
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.96109524
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.95637005
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91151698
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88714798
24KDM2B_26808549_Chip-Seq_DND41_Human1.88271071
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84569458
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83230243
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82106325
28TCF7_22412390_ChIP-Seq_EML_Mouse1.81321787
29MYC_22102868_ChIP-Seq_BL_Human1.78194503
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.76228995
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75473051
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75466898
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74490937
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73821190
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73045229
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.71344700
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70302877
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.69731433
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.69669366
40* KDM2B_26808549_Chip-Seq_JURKAT_Human1.68803157
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67168264
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65773836
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60543401
44* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60139277
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58575495
46* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54923279
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51288902
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49077818
49AR_19668381_ChIP-Seq_PC3_Human1.47380674
50ZNF274_21170338_ChIP-Seq_K562_Hela1.44153518
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43754190
52AR_21572438_ChIP-Seq_LNCaP_Human1.43530448
53SMAD4_21799915_ChIP-Seq_A2780_Human1.42959404
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.42678251
55KDM2B_26808549_Chip-Seq_K562_Human1.40202639
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39806549
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36616616
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36607106
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36607106
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36607106
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36332039
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.33904005
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.33247175
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31951060
65STAT3_23295773_ChIP-Seq_U87_Human1.31495548
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31001725
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29622490
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29454602
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28020216
70* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27927483
71* CTCF_27219007_Chip-Seq_Bcells_Human1.26330449
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.25915885
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25394789
74TP53_16413492_ChIP-PET_HCT116_Human1.22305874
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21638555
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21003973
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20830031
78* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20489142
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20132966
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19747066
81* LXR_22292898_ChIP-Seq_THP-1_Human1.19644803
82AHR_22903824_ChIP-Seq_MCF-7_Human1.19343186
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19205703
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18465556
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.17155697
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16452957
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16251605
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15774428
89NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14677812
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14278702
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14143519
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.13488700
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13231078
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13119342
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12730404
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.12522786
97PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10995295
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.09654142
99CREB1_26743006_Chip-Seq_LNCaP_Human1.09549990
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09006644
101SMC4_20622854_ChIP-Seq_HELA_Human1.08980429
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08142198
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07184968
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06931685
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06613798
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.06180664
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06154592
108TCF4_23295773_ChIP-Seq_U87_Human1.05026608
109TP53_23651856_ChIP-Seq_MEFs_Mouse1.04584007
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.03821263
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02270103
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.01918944
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.01918944
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01665631
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01284931
116* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98968923
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98857474
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.98293916
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97197235
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.96982009
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96929925
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96413967
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96327668
124RACK7_27058665_Chip-Seq_MCF-7_Human0.95289207
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94562686
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94215311
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93411213
128POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92716303
129SMAD_19615063_ChIP-ChIP_OVARY_Human0.91988416
130* ISL1_27105846_Chip-Seq_CPCs_Mouse0.91645363
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91588114
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.91251414
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90837342
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89840796
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89486551
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89407975
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89149960
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89149960
139TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88647104
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.88646309
141AR_25329375_ChIP-Seq_VCAP_Human0.87841975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.33597989
2MP0003635_abnormal_synaptic_transmissio3.44146965
3MP0004270_analgesia3.39496450
4MP0009046_muscle_twitch3.09971237
5MP0003880_abnormal_central_pattern2.72184269
6MP0002063_abnormal_learning/memory/cond2.64012798
7MP0003283_abnormal_digestive_organ2.59990412
8MP0004858_abnormal_nervous_system2.56451210
9MP0009745_abnormal_behavioral_response2.49646042
10MP0005423_abnormal_somatic_nervous2.46657487
11MP0002064_seizures2.43865605
12MP0002734_abnormal_mechanical_nocicepti2.37126899
13MP0005670_abnormal_white_adipose2.25053551
14MP0002009_preneoplasia2.20973431
15MP0002572_abnormal_emotion/affect_behav2.20971379
16MP0002272_abnormal_nervous_system2.15643062
17MP0001486_abnormal_startle_reflex2.13645375
18MP0001968_abnormal_touch/_nociception2.08969136
19MP0000778_abnormal_nervous_system1.95880068
20MP0000579_abnormal_nail_morphology1.92506309
21MP0002184_abnormal_innervation1.90863276
22MP0004084_abnormal_cardiac_muscle1.90069080
23MP0000569_abnormal_digit_pigmentation1.89791369
24MP0009780_abnormal_chondrocyte_physiolo1.77309284
25MP0002822_catalepsy1.70564507
26MP0002735_abnormal_chemical_nociception1.68963325
27MP0002249_abnormal_larynx_morphology1.68473661
28MP0002067_abnormal_sensory_capabilities1.68169598
29MP0004036_abnormal_muscle_relaxation1.67914780
30MP0004811_abnormal_neuron_physiology1.67787518
31MP0004145_abnormal_muscle_electrophysio1.66708521
32MP0003879_abnormal_hair_cell1.65140757
33MP0000955_abnormal_spinal_cord1.64275811
34MP0004233_abnormal_muscle_weight1.62948707
35MP0008569_lethality_at_weaning1.62267497
36MP0005409_darkened_coat_color1.60336632
37MP0008057_abnormal_DNA_replication1.57858576
38MP0010630_abnormal_cardiac_muscle1.57557094
39MP0002733_abnormal_thermal_nociception1.56066498
40MP0004885_abnormal_endolymph1.55602349
41MP0000566_synostosis1.55365195
42MP0002557_abnormal_social/conspecific_i1.55198850
43MP0003122_maternal_imprinting1.52168048
44MP0003705_abnormal_hypodermis_morpholog1.52044169
45MP0004510_myositis1.49663786
46MP0002909_abnormal_adrenal_gland1.45366490
47MP0001970_abnormal_pain_threshold1.44027633
48MP0006138_congestive_heart_failure1.43496417
49MP0004087_abnormal_muscle_fiber1.41258249
50MP0009672_abnormal_birth_weight1.40844479
51MP0005623_abnormal_meninges_morphology1.40381930
52MP0005386_behavior/neurological_phenoty1.39640786
53MP0004924_abnormal_behavior1.39640786
54MP0001440_abnormal_grooming_behavior1.39177324
55MP0004130_abnormal_muscle_cell1.38977696
56MP0001849_ear_inflammation1.35989862
57MP0001501_abnormal_sleep_pattern1.35901777
58MP0002882_abnormal_neuron_morphology1.33696710
59MP0002152_abnormal_brain_morphology1.28179424
60MP0002736_abnormal_nociception_after1.27949769
61MP0009278_abnormal_bone_marrow1.27600018
62MP0003890_abnormal_embryonic-extraembry1.27249339
63MP0003787_abnormal_imprinting1.25103939
64MP0005666_abnormal_adipose_tissue1.24651536
65MP0001299_abnormal_eye_distance/1.24480828
66MP0002653_abnormal_ependyma_morphology1.23817895
67MP0002066_abnormal_motor_capabilities/c1.22733573
68MP0003119_abnormal_digestive_system1.20155429
69MP0003045_fibrosis1.19513348
70MP0005645_abnormal_hypothalamus_physiol1.18565593
71MP0000537_abnormal_urethra_morphology1.18249391
72MP0003632_abnormal_nervous_system1.16550470
73MP0000751_myopathy1.16504426
74MP0003567_abnormal_fetal_cardiomyocyte1.13979829
75MP0003861_abnormal_nervous_system1.10850455
76MP0000428_abnormal_craniofacial_morphol1.08944735
77MP0000747_muscle_weakness1.07574875
78MP0004133_heterotaxia1.07511333
79MP0008961_abnormal_basal_metabolism1.07381699
80MP0004142_abnormal_muscle_tone1.07274222
81MP0003121_genomic_imprinting1.06286795
82MP0001188_hyperpigmentation1.04470434
83MP0003329_amyloid_beta_deposits1.04309147
84MP0005646_abnormal_pituitary_gland1.03550341
85MP0003633_abnormal_nervous_system1.03222638
86MP0003631_nervous_system_phenotype1.01659340
87MP0001984_abnormal_olfaction1.01518070
88MP0002106_abnormal_muscle_physiology1.01507936
89MP0006276_abnormal_autonomic_nervous0.99775727
90MP0001502_abnormal_circadian_rhythm0.98662585
91MP0000733_abnormal_muscle_development0.98027087
92MP0000462_abnormal_digestive_system0.97368891
93MP0003137_abnormal_impulse_conducting0.97226266
94MP0000631_abnormal_neuroendocrine_gland0.94860059
95MP0004185_abnormal_adipocyte_glucose0.92623409
96MP0003123_paternal_imprinting0.92276312
97MP0000759_abnormal_skeletal_muscle0.92167629
98MP0003634_abnormal_glial_cell0.91888070
99MP0005369_muscle_phenotype0.91344605
100MP0002254_reproductive_system_inflammat0.91035257
101MP0009703_decreased_birth_body0.90851722
102MP0001485_abnormal_pinna_reflex0.90434683
103MP0005620_abnormal_muscle_contractility0.89199627
104MP0004381_abnormal_hair_follicle0.88556181
105MP0006072_abnormal_retinal_apoptosis0.88421131
106MP0002234_abnormal_pharynx_morphology0.88319084
107MP0005330_cardiomyopathy0.87253922
108MP0003115_abnormal_respiratory_system0.85699032
109MP0002697_abnormal_eye_size0.85019015
110MP0005499_abnormal_olfactory_system0.84932303
111MP0005394_taste/olfaction_phenotype0.84932303
112MP0002638_abnormal_pupillary_reflex0.84852134
113MP0000432_abnormal_head_morphology0.84847176
114MP0004215_abnormal_myocardial_fiber0.84469193
115MP0002751_abnormal_autonomic_nervous0.84017616
116MP0000534_abnormal_ureter_morphology0.83960409
117MP0000749_muscle_degeneration0.82616333
118MP0004742_abnormal_vestibular_system0.81982105
119MP0003878_abnormal_ear_physiology0.81537258
120MP0005377_hearing/vestibular/ear_phenot0.81537258
121MP0001177_atelectasis0.81282981
122MP0004197_abnormal_fetal_growth/weight/0.81063663
123MP0004085_abnormal_heartbeat0.80669677
124MP0002229_neurodegeneration0.80340652
125MP0001348_abnormal_lacrimal_gland0.78399802
126MP0002089_abnormal_postnatal_growth/wei0.78129207
127MP0005076_abnormal_cell_differentiation0.77983441
128MP0005551_abnormal_eye_electrophysiolog0.77447199
129MP0002752_abnormal_somatic_nervous0.77419815
130MP0005187_abnormal_penis_morphology0.75774819
131MP0002269_muscular_atrophy0.73993126
132MP0006292_abnormal_olfactory_placode0.70755461
133MP0001529_abnormal_vocalization0.70321797
134MP0010769_abnormal_survival0.68305802
135MP0001943_abnormal_respiration0.67604646
136MP0001293_anophthalmia0.67461322
137MP0010386_abnormal_urinary_bladder0.66836768
138MP0010770_preweaning_lethality0.66801647
139MP0002082_postnatal_lethality0.66801647
140MP0010768_mortality/aging0.65191028
141MP0000013_abnormal_adipose_tissue0.65136072
142MP0002081_perinatal_lethality0.64870090
143MP0002069_abnormal_eating/drinking_beha0.64171376

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.67332270
2Myokymia (HP:0002411)4.43003866
3Action tremor (HP:0002345)4.31687940
4Focal seizures (HP:0007359)4.22965278
5Obstructive sleep apnea (HP:0002870)4.19524909
6Progressive cerebellar ataxia (HP:0002073)3.77868552
7Visual hallucinations (HP:0002367)3.65558521
8Epileptic encephalopathy (HP:0200134)3.45441429
9Abnormality of the lower motor neuron (HP:0002366)3.40159751
10Abnormality of the fingertips (HP:0001211)3.13774311
11Genetic anticipation (HP:0003743)3.13654154
12Sudden death (HP:0001699)3.10546594
13Impaired smooth pursuit (HP:0007772)3.06190750
14Gaze-evoked nystagmus (HP:0000640)3.05688329
15Abnormality of the astrocytes (HP:0100707)2.96522965
16Astrocytoma (HP:0009592)2.96522965
17Subaortic stenosis (HP:0001682)2.88908016
18Abnormality of the left ventricular outflow tract (HP:0011103)2.88908016
19Dysdiadochokinesis (HP:0002075)2.87747970
20Febrile seizures (HP:0002373)2.87723262
21Abnormality of the aortic arch (HP:0012303)2.81768206
22Absence seizures (HP:0002121)2.78870537
23Abnormality of ocular smooth pursuit (HP:0000617)2.77218318
24Dysmetric saccades (HP:0000641)2.76226280
25Vertebral arch anomaly (HP:0008438)2.74644864
26Bundle branch block (HP:0011710)2.70115269
27Poor eye contact (HP:0000817)2.68068107
28Hyporeflexia of lower limbs (HP:0002600)2.65976804
29Atonic seizures (HP:0010819)2.62346267
30Broad face (HP:0000283)2.62212122
31Urinary bladder sphincter dysfunction (HP:0002839)2.61263653
32Broad-based gait (HP:0002136)2.58854666
33Hemiparesis (HP:0001269)2.53932339
34Ankle clonus (HP:0011448)2.49654370
35Turricephaly (HP:0000262)2.49439201
36Generalized tonic-clonic seizures (HP:0002069)2.46875765
37Ependymoma (HP:0002888)2.45415679
38Impaired social interactions (HP:0000735)2.44836070
39Abnormal social behavior (HP:0012433)2.44836070
40Bronchomalacia (HP:0002780)2.44541454
41Dialeptic seizures (HP:0011146)2.43632225
42Hemiplegia (HP:0002301)2.39144733
43Pointed chin (HP:0000307)2.38856111
44Truncal ataxia (HP:0002078)2.36600995
45Glioma (HP:0009733)2.34770364
46Depression (HP:0000716)2.34518190
47Impaired vibration sensation in the lower limbs (HP:0002166)2.33076053
48Postural instability (HP:0002172)2.32974639
49Atrial fibrillation (HP:0005110)2.32870521
50Scanning speech (HP:0002168)2.30830796
51Drooling (HP:0002307)2.29812920
52Excessive salivation (HP:0003781)2.29812920
53Epileptiform EEG discharges (HP:0011182)2.29596917
54EEG with generalized epileptiform discharges (HP:0011198)2.25812722
55Syncope (HP:0001279)2.23171389
56Abnormality of the labia minora (HP:0012880)2.22581209
57Dysmetria (HP:0001310)2.22328803
58Laryngomalacia (HP:0001601)2.22285684
59Cerebral aneurysm (HP:0004944)2.19090347
60Trigonocephaly (HP:0000243)2.18016912
61Ventricular tachycardia (HP:0004756)2.17791681
62Narrow palate (HP:0000189)2.14983369
63EMG: neuropathic changes (HP:0003445)2.14257416
64Esophageal atresia (HP:0002032)2.11697129
65Truncal obesity (HP:0001956)2.10544209
66Neoplasm of the oral cavity (HP:0100649)2.09215799
67Skull defect (HP:0001362)2.09132085
68Macroorchidism (HP:0000053)2.09067894
69Supranuclear gaze palsy (HP:0000605)2.08625725
70Urinary urgency (HP:0000012)2.07663904
71Hypsarrhythmia (HP:0002521)2.07030028
72Right ventricular cardiomyopathy (HP:0011663)2.06819246
73Primary atrial arrhythmia (HP:0001692)2.06499115
74Neoplasm of the heart (HP:0100544)2.04833660
75Termporal pattern (HP:0011008)2.04636453
76Insidious onset (HP:0003587)2.04636453
77Annular pancreas (HP:0001734)2.04500134
78Abnormality of the columella (HP:0009929)2.03120841
79High anterior hairline (HP:0009890)2.02874194
80Absent speech (HP:0001344)2.01740005
81Neonatal hypoglycemia (HP:0001998)1.99901535
82Amyotrophic lateral sclerosis (HP:0007354)1.97913473
83Intention tremor (HP:0002080)1.97058924
84Aqueductal stenosis (HP:0002410)1.96813917
85Long eyelashes (HP:0000527)1.95886246
86Abnormality of the corticospinal tract (HP:0002492)1.94955005
87Ankyloglossia (HP:0010296)1.94579914
88Choanal stenosis (HP:0000452)1.93378872
89Atrioventricular block (HP:0001678)1.92213915
90Supraventricular tachycardia (HP:0004755)1.92086621
91Resting tremor (HP:0002322)1.91973738
92Hypoventilation (HP:0002791)1.90686204
93Precocious puberty (HP:0000826)1.89950804
94Broad thumb (HP:0011304)1.88902413
95Amblyopia (HP:0000646)1.88843298
96Sleep apnea (HP:0010535)1.87908757
97Insomnia (HP:0100785)1.87114502
98Supraventricular arrhythmia (HP:0005115)1.86592593
99Abnormality of the ischium (HP:0003174)1.85217027
100Diplopia (HP:0000651)1.83115763
101Abnormality of binocular vision (HP:0011514)1.83115763
102Tracheomalacia (HP:0002779)1.82951188
103Ventricular fibrillation (HP:0001663)1.82689585
104Spastic gait (HP:0002064)1.82550927
105Depressed nasal tip (HP:0000437)1.82335957
106Abnormality of the distal phalanx of the thumb (HP:0009617)1.82089210
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.81675732
108Heart block (HP:0012722)1.81531547
109Cutaneous syndactyly (HP:0012725)1.81472850
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80948842
111Short 4th metacarpal (HP:0010044)1.80948842
112Hypoplastic ischia (HP:0003175)1.78454890
113Obsessive-compulsive behavior (HP:0000722)1.75633707
114Hepatoblastoma (HP:0002884)1.75371579
115Bradykinesia (HP:0002067)1.75323208
116Postural tremor (HP:0002174)1.75137702
117Prolonged QT interval (HP:0001657)1.74828791
118Cutaneous finger syndactyly (HP:0010554)1.74262382
119Alacrima (HP:0000522)1.72608661
120Broad metatarsal (HP:0001783)1.72326658
121Stereotypic behavior (HP:0000733)1.71634489
122Lower limb amyotrophy (HP:0007210)1.70657742
123Hyperacusis (HP:0010780)1.69954199
124Short chin (HP:0000331)1.69528359
125Renal duplication (HP:0000075)1.69508917
126Hammertoe (HP:0001765)1.69401363
127Peripheral hypomyelination (HP:0007182)1.68331420
128Mutism (HP:0002300)1.68095584
129Persistence of primary teeth (HP:0006335)1.67043109
130Abnormality of chromosome segregation (HP:0002916)1.67029814
131Abnormality of the 4th metacarpal (HP:0010012)1.66721624
132Distal lower limb amyotrophy (HP:0008944)1.66396740
133Impaired vibratory sensation (HP:0002495)1.66243846
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65270169
135Distal upper limb amyotrophy (HP:0007149)1.65244422
136Upper limb amyotrophy (HP:0009129)1.65244422
137Spina bifida occulta (HP:0003298)1.64628059
138Clonus (HP:0002169)1.64415032
139Renovascular hypertension (HP:0100817)1.64274545
140Elfin facies (HP:0004428)1.64240186
141Abnormal atrioventricular conduction (HP:0005150)1.63985233
142Hypoplasia of the maxilla (HP:0000327)1.62956657
143Difficulty climbing stairs (HP:0003551)1.62658665
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.61675064
145Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61284046
146Open mouth (HP:0000194)1.60553889
147Selective tooth agenesis (HP:0001592)1.60542676
148Intellectual disability, profound (HP:0002187)1.60362795
149Shallow orbits (HP:0000586)1.59481670
150Abnormal hair whorl (HP:0010721)1.59206188
151Broad finger (HP:0001500)1.58791019
152Sporadic (HP:0003745)1.58390268
153Germ cell neoplasia (HP:0100728)1.58311013
154Dislocated radial head (HP:0003083)1.56982950
155Anxiety (HP:0000739)1.56559530
156Hyperventilation (HP:0002883)1.56306789
157Onion bulb formation (HP:0003383)1.56065660
158Lower limb muscle weakness (HP:0007340)1.55877845
159Agitation (HP:0000713)1.55030089
160Tetraplegia (HP:0002445)1.54888980
161Gait ataxia (HP:0002066)1.54480457
162Abnormal eating behavior (HP:0100738)1.52808889
163Oligodactyly (hands) (HP:0001180)1.52713739
164Urethral obstruction (HP:0000796)1.52217197
165Sacral dimple (HP:0000960)1.52204033
166Shawl scrotum (HP:0000049)1.52154429
167Difficulty running (HP:0009046)1.51519970
168Attention deficit hyperactivity disorder (HP:0007018)1.51240854
169Hand muscle atrophy (HP:0009130)1.51159349
170Anophthalmia (HP:0000528)1.50802462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.79189536
2MAP3K93.74113582
3EEF2K3.18044473
4TRIB32.99875993
5MAP3K42.99452735
6MARK12.93819870
7EPHA42.83363747
8PAK62.39864311
9PRKD32.38794354
10NTRK22.34357406
11MAP3K102.33627432
12MINK12.32239556
13TTN2.30225505
14DAPK22.19780685
15SMG12.10873305
16KSR12.07332330
17INSRR2.03136510
18PNCK1.98584994
19NTRK11.93974170
20RIPK11.88066982
21FGFR41.87040744
22FGFR21.80551367
23CDK121.73626689
24TYRO31.70601108
25CAMKK11.63695157
26MAP2K71.56314581
27STK381.53554868
28MAP2K41.53298094
29KSR21.52680217
30CAMK1G1.46020605
31DAPK11.42674709
32MAP3K71.42143098
33SIK11.40107428
34PRPF4B1.38691304
35LATS21.38550594
36ICK1.33100277
37ALK1.30152040
38CDK51.29820879
39SCYL21.23997503
40SIK21.20990066
41CAMKK21.20964854
42TNK21.20551932
43NEK11.19401713
44MAPK131.11098550
45CDC42BPA1.08190811
46WNK31.06298729
47AKT31.03999492
48MARK21.01595698
49TNIK0.97156808
50PAK30.93617660
51CDK180.90948760
52CDK150.90676564
53UHMK10.88916321
54STK110.88126090
55FGFR30.87255067
56TAOK10.86513853
57PRKCG0.86321438
58PDGFRB0.86228057
59PASK0.85935468
60PHKG20.85052029
61PHKG10.85052029
62CAMK1D0.84529521
63NLK0.84289265
64CDK140.84165910
65SGK20.83042577
66CASK0.82233744
67RPS6KA20.81919986
68RET0.80526314
69CAMK40.79841052
70EPHB10.78964753
71SGK2230.78835868
72SGK4940.78835868
73WNK10.78563394
74SGK30.78007072
75CAMK10.77833412
76PKN20.77418421
77CDK11A0.77107586
78DMPK0.76022237
79PLK20.75858268
80MAP3K20.74743861
81RPS6KL10.72805432
82RPS6KC10.72805432
83EPHA20.72268192
84GRK50.72247570
85PTK20.71085897
86SGK10.70948913
87ERBB20.69833459
88PRKCH0.69293284
89RPS6KA30.66437394
90DYRK1A0.65556130
91CAMK2B0.64720546
92PDGFRA0.63996489
93BRD40.63972371
94MAPK100.63007519
95RPS6KA60.62791464
96CAMK2A0.61720355
97MTOR0.61114021
98RPS6KA10.60875925
99LMTK20.60106872
100LATS10.58311911
101HIPK20.57622112
102DYRK20.56679409
103OBSCN0.56585705
104CSNK1E0.55854919
105CDK190.52157855
106GSK3B0.51219804
107PRKDC0.49960053
108MAPK120.49880797
109CSNK1D0.49640519
110PRKD20.49023201
111DDR20.46353990
112BCR0.46324117
113CDC70.45394371
114FER0.44109918
115SIK30.44101707
116MAPK80.43981893
117ROCK20.43735679
118ITK0.43629680
119NEK60.41081176
120MAPK150.40570637
121EPHA30.40183984
122PRKAA10.39642750
123FYN0.39590074
124DAPK30.39449650
125CDK20.38962203
126FGFR10.38719746
127MAPK90.38508957
128BMX0.38443656
129CAMK2D0.38292696
130PRKCZ0.38218417
131CHEK10.38033586
132AKT10.37938249
133PRKCB0.37727338
134ROCK10.37291629
135MYLK0.37233060
136CDK10.36579439
137EPHB20.36259017
138MAP3K60.34737993
139PAK20.34445306
140MELK0.33888085
141PRKD10.33083015

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39858507
2Synaptic vesicle cycle_Homo sapiens_hsa047212.79962171
3Circadian entrainment_Homo sapiens_hsa047132.55195470
4Long-term potentiation_Homo sapiens_hsa047202.44210948
5GABAergic synapse_Homo sapiens_hsa047272.40399395
6Glutamatergic synapse_Homo sapiens_hsa047242.37575170
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33096274
8Insulin secretion_Homo sapiens_hsa049112.20611310
9Morphine addiction_Homo sapiens_hsa050322.17134754
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15982288
11Amphetamine addiction_Homo sapiens_hsa050312.10524423
12Olfactory transduction_Homo sapiens_hsa047402.09083074
13Salivary secretion_Homo sapiens_hsa049702.00081898
14Notch signaling pathway_Homo sapiens_hsa043301.92745946
15Dopaminergic synapse_Homo sapiens_hsa047281.91950791
16Taste transduction_Homo sapiens_hsa047421.78284795
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77905775
18Cholinergic synapse_Homo sapiens_hsa047251.74741926
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73862903
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68203768
21Type II diabetes mellitus_Homo sapiens_hsa049301.63860651
22Gastric acid secretion_Homo sapiens_hsa049711.56982832
23Lysine degradation_Homo sapiens_hsa003101.56108486
24Long-term depression_Homo sapiens_hsa047301.55771667
25Oxytocin signaling pathway_Homo sapiens_hsa049211.54898425
26Renin secretion_Homo sapiens_hsa049241.46427038
27Cocaine addiction_Homo sapiens_hsa050301.45649692
28Calcium signaling pathway_Homo sapiens_hsa040201.44522437
29Gap junction_Homo sapiens_hsa045401.42361309
30Axon guidance_Homo sapiens_hsa043601.34898696
31Serotonergic synapse_Homo sapiens_hsa047261.34865973
32GnRH signaling pathway_Homo sapiens_hsa049121.34818015
33Dilated cardiomyopathy_Homo sapiens_hsa054141.29483932
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28807466
35cAMP signaling pathway_Homo sapiens_hsa040241.26156094
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23360786
37Estrogen signaling pathway_Homo sapiens_hsa049151.21974755
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20829775
39Chronic myeloid leukemia_Homo sapiens_hsa052201.20825560
40Oocyte meiosis_Homo sapiens_hsa041141.19477369
41Melanogenesis_Homo sapiens_hsa049161.17269157
42Glioma_Homo sapiens_hsa052141.15046288
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12356868
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10977900
45ErbB signaling pathway_Homo sapiens_hsa040121.10524748
46AMPK signaling pathway_Homo sapiens_hsa041521.10168834
47Alcoholism_Homo sapiens_hsa050341.09168317
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07099672
49T cell receptor signaling pathway_Homo sapiens_hsa046601.06930471
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06715038
51Prostate cancer_Homo sapiens_hsa052151.06434640
52Dorso-ventral axis formation_Homo sapiens_hsa043201.00181876
53mTOR signaling pathway_Homo sapiens_hsa041500.99383890
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97639211
55Hedgehog signaling pathway_Homo sapiens_hsa043400.93738756
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.93412413
57Thyroid cancer_Homo sapiens_hsa052160.91328599
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90848160
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90720210
60Vitamin B6 metabolism_Homo sapiens_hsa007500.89515374
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89014094
62Acute myeloid leukemia_Homo sapiens_hsa052210.88621811
63Hippo signaling pathway_Homo sapiens_hsa043900.88135845
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.86780756
65Thyroid hormone synthesis_Homo sapiens_hsa049180.86739160
66Wnt signaling pathway_Homo sapiens_hsa043100.85387473
67Pancreatic secretion_Homo sapiens_hsa049720.84080910
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82005563
69Basal cell carcinoma_Homo sapiens_hsa052170.81297467
70Prolactin signaling pathway_Homo sapiens_hsa049170.79970736
71Cardiac muscle contraction_Homo sapiens_hsa042600.79699699
72MAPK signaling pathway_Homo sapiens_hsa040100.77902580
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.74638730
74Circadian rhythm_Homo sapiens_hsa047100.74140918
75Endometrial cancer_Homo sapiens_hsa052130.73990599
76Choline metabolism in cancer_Homo sapiens_hsa052310.73430102
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71471013
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71442255
79Tight junction_Homo sapiens_hsa045300.71029993
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69874417
81Rap1 signaling pathway_Homo sapiens_hsa040150.69757960
82Pancreatic cancer_Homo sapiens_hsa052120.67255020
83Glucagon signaling pathway_Homo sapiens_hsa049220.66282332
84FoxO signaling pathway_Homo sapiens_hsa040680.65491847
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64862852
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64678708
87Colorectal cancer_Homo sapiens_hsa052100.63887764
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63813912
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62623107
90Nitrogen metabolism_Homo sapiens_hsa009100.62357782
91Insulin resistance_Homo sapiens_hsa049310.61666680
92Inositol phosphate metabolism_Homo sapiens_hsa005620.61481903
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61151411
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60555775
95Pathways in cancer_Homo sapiens_hsa052000.58844734
96Prion diseases_Homo sapiens_hsa050200.58260465
97ECM-receptor interaction_Homo sapiens_hsa045120.57572579
98Renal cell carcinoma_Homo sapiens_hsa052110.56462516
99Adherens junction_Homo sapiens_hsa045200.55360743
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53848808
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.53614456
102Insulin signaling pathway_Homo sapiens_hsa049100.52529803
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52496992
104Proteoglycans in cancer_Homo sapiens_hsa052050.51435392
105VEGF signaling pathway_Homo sapiens_hsa043700.50744562
106Ras signaling pathway_Homo sapiens_hsa040140.50667864
107Non-small cell lung cancer_Homo sapiens_hsa052230.46831360
108MicroRNAs in cancer_Homo sapiens_hsa052060.46369196
109Vibrio cholerae infection_Homo sapiens_hsa051100.45231371
110mRNA surveillance pathway_Homo sapiens_hsa030150.43521324
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42856154
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42608873
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.42315983
114Collecting duct acid secretion_Homo sapiens_hsa049660.42115245
115Endocytosis_Homo sapiens_hsa041440.42012763
116Focal adhesion_Homo sapiens_hsa045100.40855482
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40697412
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38971092
119Phototransduction_Homo sapiens_hsa047440.38932549

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