IHH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to leptin stimulus (GO:0044320)8.21784297
2oocyte development (GO:0048599)7.60085223
3sex determination (GO:0007530)7.21654709
43-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)7.10775612
5purine ribonucleoside bisphosphate metabolic process (GO:0034035)7.10775612
6response to leptin (GO:0044321)6.72946247
7sulfate transmembrane transport (GO:1902358)6.33232519
8cellular ketone body metabolic process (GO:0046950)5.93719652
9flavonoid metabolic process (GO:0009812)5.92522937
10activin receptor signaling pathway (GO:0032924)5.89202540
11intestinal absorption (GO:0050892)5.70724040
12sulfate transport (GO:0008272)5.33681819
13sulfur amino acid catabolic process (GO:0000098)5.31745243
14ketone body metabolic process (GO:1902224)5.12666770
15endothelial cell chemotaxis (GO:0035767)4.89774555
16cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.86374361
17negative regulation of macrophage differentiation (GO:0045650)4.85620082
18bile acid and bile salt transport (GO:0015721)4.80751237
19phosphate ion transmembrane transport (GO:0035435)4.74807818
20negative regulation of cytokine biosynthetic process (GO:0042036)4.69338960
21regulation of guanylate cyclase activity (GO:0031282)4.68902809
22drug transmembrane transport (GO:0006855)4.64363997
23regulation of cholesterol homeostasis (GO:2000188)4.63476610
24negative regulation of sterol transport (GO:0032372)4.58496098
25negative regulation of cholesterol transport (GO:0032375)4.58496098
26cellular glucuronidation (GO:0052695)4.57505528
27ovarian follicle development (GO:0001541)4.39594248
28sulfur compound transport (GO:0072348)4.37217682
29intestinal cholesterol absorption (GO:0030299)4.35707919
30phosphate ion transport (GO:0006817)4.29268501
31atrioventricular valve morphogenesis (GO:0003181)4.28930718
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.28332947
33glucuronate metabolic process (GO:0019585)4.24385996
34uronic acid metabolic process (GO:0006063)4.24385996
35regulation of cardioblast differentiation (GO:0051890)4.18553666
36hemoglobin metabolic process (GO:0020027)4.17335762
37renal system process involved in regulation of blood volume (GO:0001977)4.16200550
38negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.14607066
39purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.12987623
40ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.12987623
41nucleoside bisphosphate biosynthetic process (GO:0033866)4.12987623
42cellular response to gonadotropin stimulus (GO:0071371)4.12035623
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.10209382
44drug catabolic process (GO:0042737)4.05303116
45drug transport (GO:0015893)4.04438088
46glucocorticoid biosynthetic process (GO:0006704)4.03388004
47actin filament depolymerization (GO:0030042)4.03310875
48negative regulation of insulin secretion (GO:0046676)4.02571323
49cytidine metabolic process (GO:0046087)4.02282679
50cytidine catabolic process (GO:0006216)4.02282679
51cytidine deamination (GO:0009972)4.02282679
52urea cycle (GO:0000050)3.96434711
53male sex determination (GO:0030238)3.93213955
54gonadal mesoderm development (GO:0007506)3.92384757
55cardiac right ventricle morphogenesis (GO:0003215)3.88544922
56endocardial cushion development (GO:0003197)3.86026535
57Leydig cell differentiation (GO:0033327)3.81691934
58urea metabolic process (GO:0019627)3.80476473
59negative regulation of peptide hormone secretion (GO:0090278)3.78816750
60negative regulation of protein tyrosine kinase activity (GO:0061099)3.78536070
61UDP-N-acetylglucosamine metabolic process (GO:0006047)3.77832082
62NADH metabolic process (GO:0006734)3.71575101
63nucleoside bisphosphate metabolic process (GO:0033865)3.71105823
64purine nucleoside bisphosphate metabolic process (GO:0034032)3.71105823
65ribonucleoside bisphosphate metabolic process (GO:0033875)3.71105823
66regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.69892102
67endocrine process (GO:0050886)3.69892102
68regulation of systemic arterial blood pressure by hormone (GO:0001990)3.69892102
69positive regulation of guanylate cyclase activity (GO:0031284)3.68516984
70ovulation cycle process (GO:0022602)3.67712452
71negative regulation of peptide secretion (GO:0002792)3.66881240
72calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.66675433
73ethanol oxidation (GO:0006069)3.66570957
74regulation of bile acid biosynthetic process (GO:0070857)3.66285735
75estrogen biosynthetic process (GO:0006703)3.65577699
76intestinal epithelial cell development (GO:0060576)3.64377311
77adhesion of symbiont to host (GO:0044406)3.61955345
78regulation of endocrine process (GO:0044060)3.60056632
79angiotensin maturation (GO:0002003)3.59837069
80cysteine metabolic process (GO:0006534)3.57973277
81negative regulation of macroautophagy (GO:0016242)3.56592601
82negative regulation of keratinocyte proliferation (GO:0010839)3.55166069
83anatomical structure regression (GO:0060033)3.54789206
84nucleotide-sugar biosynthetic process (GO:0009226)3.52921985
85protein retention in ER lumen (GO:0006621)3.51438230
86regulation of transforming growth factor beta2 production (GO:0032909)3.51176903
87lysine catabolic process (GO:0006554)3.49284589
88lysine metabolic process (GO:0006553)3.49284589
89embryonic foregut morphogenesis (GO:0048617)3.48440674
90regulation of vitamin metabolic process (GO:0030656)3.47085703
91sulfation (GO:0051923)3.44947724
92epoxygenase P450 pathway (GO:0019373)3.43407512
93renal absorption (GO:0070293)3.39962282
94sex differentiation (GO:0007548)3.38242049
95alkaloid metabolic process (GO:0009820)3.36343179
96desmosome organization (GO:0002934)3.35736971
97urogenital system development (GO:0001655)3.35690236
98nitrogen cycle metabolic process (GO:0071941)3.35271189
99regulation of systemic arterial blood pressure (GO:0003073)3.32671061
100positive regulation of fatty acid beta-oxidation (GO:0032000)3.32206858
101positive regulation of reproductive process (GO:2000243)3.30080887
102homocysteine metabolic process (GO:0050667)3.29629015
103urate metabolic process (GO:0046415)3.29268705
104modified amino acid transport (GO:0072337)3.28681629
105exogenous drug catabolic process (GO:0042738)3.27444073
106phosphatidylcholine biosynthetic process (GO:0006656)3.26690388
107short-chain fatty acid metabolic process (GO:0046459)3.23981829
108galactose metabolic process (GO:0006012)3.22913869
109sterol homeostasis (GO:0055092)3.21514489
110regulation of autophagic vacuole assembly (GO:2000785)3.20885116
111cholesterol homeostasis (GO:0042632)3.20440918
112basement membrane organization (GO:0071711)3.20391260
113fructose metabolic process (GO:0006000)3.19882655
114gap junction assembly (GO:0016264)3.18650230
115renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.18301086
116response to hepatocyte growth factor (GO:0035728)3.16765524
117cellular response to hepatocyte growth factor stimulus (GO:0035729)3.16765524
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16697294
119phospholipid homeostasis (GO:0055091)3.15465798
120response to follicle-stimulating hormone (GO:0032354)3.14918650
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13164374
122drug metabolic process (GO:0017144)3.12002300
123glutathione metabolic process (GO:0006749)3.10339425
124vitamin transmembrane transport (GO:0035461)3.03770997
125maintenance of gastrointestinal epithelium (GO:0030277)3.00404639
126vitamin A metabolic process (GO:0006776)3.00081140
127nucleoside diphosphate biosynthetic process (GO:0009133)2.96410592
128glutathione derivative metabolic process (GO:1901685)2.96215993
129glutathione derivative biosynthetic process (GO:1901687)2.96215993
130galactose catabolic process (GO:0019388)2.95231990
131cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.94045840
132SMAD protein signal transduction (GO:0060395)2.93732095
133positive regulation of respiratory burst (GO:0060267)2.92693759
134pyrimidine ribonucleoside catabolic process (GO:0046133)2.92383837
135glyoxylate metabolic process (GO:0046487)2.92381502
136auditory receptor cell differentiation (GO:0042491)2.91879367
137steroid hormone mediated signaling pathway (GO:0043401)2.90983750
138* embryonic eye morphogenesis (GO:0048048)2.90597186
139ethanol metabolic process (GO:0006067)2.90289892
140neurotransmitter biosynthetic process (GO:0042136)2.90286384
141very-low-density lipoprotein particle assembly (GO:0034379)2.89681281
142protein neddylation (GO:0045116)2.88563733
143lipoprotein metabolic process (GO:0042157)2.87194699
144establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.86009726
145fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85252782
146negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.84767693
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.84570398
148digestive system process (GO:0022600)2.84455712
149negative regulation of hormone secretion (GO:0046888)2.82223781
150receptor guanylyl cyclase signaling pathway (GO:0007168)2.82041865
151arginine metabolic process (GO:0006525)2.81912112
152fat-soluble vitamin biosynthetic process (GO:0042362)2.81097447
153response to food (GO:0032094)2.81094691
154regulation of cGMP biosynthetic process (GO:0030826)2.80690739
155citrulline metabolic process (GO:0000052)2.80364623
156cardiac muscle hypertrophy in response to stress (GO:0014898)2.80257180
157muscle hypertrophy in response to stress (GO:0003299)2.80257180
158cardiac muscle adaptation (GO:0014887)2.80257180
159cGMP-mediated signaling (GO:0019934)2.79573678
160regulation of sterol transport (GO:0032371)2.78346223
161regulation of cholesterol transport (GO:0032374)2.78346223
162positive regulation of male gonad development (GO:2000020)2.77744418
163ATP synthesis coupled proton transport (GO:0015986)2.77419198
164energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77419198
165glutamine family amino acid biosynthetic process (GO:0009084)2.77248414
166glucose 6-phosphate metabolic process (GO:0051156)2.75051278
167regulation of cholesterol storage (GO:0010885)2.74883541
168positive regulation of prostaglandin secretion (GO:0032308)2.74750348
169pyrimidine-containing compound transmembrane transport (GO:0072531)2.74602667
170proline biosynthetic process (GO:0006561)2.74133967
171sphingomyelin metabolic process (GO:0006684)2.73836179
172hormone catabolic process (GO:0042447)2.71678470
173positive regulation of epidermal cell differentiation (GO:0045606)2.70946527
174female gonad development (GO:0008585)2.70644225
175vitamin transport (GO:0051180)2.69452847
176positive regulation of lipoprotein lipase activity (GO:0051006)2.68682637
177positive regulation of triglyceride lipase activity (GO:0061365)2.68682637
178regulation of gonadotropin secretion (GO:0032276)15.5248974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.73355249
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.73921536
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.93627296
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.52191793
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.51899540
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.46777447
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27008848
8* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.16314615
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.04292838
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.77133632
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.57113176
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.49644222
13SOX2_20726797_ChIP-Seq_SW620_Human2.34845694
14* GATA4_25053715_ChIP-Seq_YYC3_Human2.30756358
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28891994
16* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27415451
17ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.27031376
18NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.26375307
19GATA6_25053715_ChIP-Seq_YYC3_Human2.16572882
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11035019
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93874486
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90039146
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86538418
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81895343
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.81855371
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71051763
27CLOCK_20551151_ChIP-Seq_293T_Human1.70597884
28RACK7_27058665_Chip-Seq_MCF-7_Human1.70221456
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69190141
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66123411
31AR_21909140_ChIP-Seq_LNCAP_Human1.65847993
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64782977
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.63278607
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.62925644
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61371908
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.61209422
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60829003
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58570123
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58123688
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54803560
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52985027
42VDR_22108803_ChIP-Seq_LS180_Human1.50931718
43* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.49191992
44KDM2B_26808549_Chip-Seq_K562_Human1.48021678
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.47095492
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46222214
47EGR1_19032775_ChIP-ChIP_M12_Human1.41341540
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40856656
49DROSHA_22980978_ChIP-Seq_HELA_Human1.40789492
50LXR_22292898_ChIP-Seq_THP-1_Human1.38806767
51KLF5_25053715_ChIP-Seq_YYC3_Human1.33003172
52ATF3_27146783_Chip-Seq_COLON_Human1.32538969
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.32074509
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31835306
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30413525
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.30126105
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29370499
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28578298
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27632909
60CREB1_26743006_Chip-Seq_LNCaP_Human1.26958700
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23546769
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22937185
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22406808
64FOXA1_25552417_ChIP-Seq_VCAP_Human1.22178753
65* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21375408
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20838953
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20604292
68* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19686902
69* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19686902
70CTCF_27219007_Chip-Seq_Bcells_Human1.19189086
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17779586
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.17504415
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16988741
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16589839
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15641832
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14803272
77HNF4A_19822575_ChIP-Seq_HepG2_Human1.13470408
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12825732
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12804898
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.12590229
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10863991
82* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10366996
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09700398
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09614226
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09524505
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09109209
87* EZH2_27294783_Chip-Seq_ESCs_Mouse1.05856572
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05657757
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04849557
90GATA3_24758297_ChIP-Seq_MCF-7_Human1.00873832
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99169556
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98492667
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98328518
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.98192318
95* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98179414
96SMC4_20622854_ChIP-Seq_HELA_Human0.98004188
97GATA2_19941826_ChIP-Seq_K562_Human0.97569630
98FOXA2_19822575_ChIP-Seq_HepG2_Human0.96504728
99POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96150138
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95686343
101TCF7_22412390_ChIP-Seq_EML_Mouse0.95382768
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95133883
103MYC_27129775_Chip-Seq_CORNEA_Mouse0.94739599
104* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94514728
105GATA1_19941826_ChIP-Seq_K562_Human0.94419003
106TP63_22573176_ChIP-Seq_HFKS_Human0.94219284
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94189637
108* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94047111
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93694660
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92662718
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92609368
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92601285
113FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92444782
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92348833
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92274270
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92237444
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92131790
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91944048
119TAF2_19829295_ChIP-Seq_ESCs_Human0.91869310
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91635390
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91381656
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.90740988
123MYC_19915707_ChIP-ChIP_AK7_Human0.90465383
124RXR_22108803_ChIP-Seq_LS180_Human0.89681270
125* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89138808
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87035765
127* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86054219
128ZNF263_19887448_ChIP-Seq_K562_Human0.84029581
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83020312
130NANOG_20526341_ChIP-Seq_ESCs_Human0.82875212
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82573356
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82573356
133SA1_27219007_Chip-Seq_Bcells_Human0.82297551
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.82290891
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.82251914
136BCOR_27268052_Chip-Seq_Bcells_Human0.80135914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.79680695
2MP0005360_urolithiasis5.73772948
3MP0005377_hearing/vestibular/ear_phenot5.36160439
4MP0003878_abnormal_ear_physiology5.36160439
5MP0010234_abnormal_vibrissa_follicle4.62384982
6MP0008875_abnormal_xenobiotic_pharmacok3.88052234
7MP0002139_abnormal_hepatobiliary_system3.86645904
8MP0001666_abnormal_nutrient_absorption3.71600425
9MP0005167_abnormal_blood-brain_barrier3.41058539
10MP0005085_abnormal_gallbladder_physiolo2.80392860
11MP0004019_abnormal_vitamin_homeostasis2.75354829
12MP0003011_delayed_dark_adaptation2.59511071
13MP0003315_abnormal_perineum_morphology2.48801225
14MP0004264_abnormal_extraembryonic_tissu2.31196683
15MP0003045_fibrosis2.28667119
16MP0004145_abnormal_muscle_electrophysio2.27753736
17MP0008995_early_reproductive_senescence2.25087764
18MP0004043_abnormal_pH_regulation2.24410947
19MP0004233_abnormal_muscle_weight2.20338570
20MP0005365_abnormal_bile_salt2.16957275
21MP0000566_synostosis2.14081535
22MP0003191_abnormal_cellular_cholesterol2.04571545
23MP0001661_extended_life_span1.98963769
24MP0009643_abnormal_urine_homeostasis1.90592277
25MP0003866_abnormal_defecation1.84888414
26* MP0000462_abnormal_digestive_system1.81835370
27MP0001765_abnormal_ion_homeostasis1.81352726
28MP0003183_abnormal_peptide_metabolism1.77546233
29MP0003252_abnormal_bile_duct1.75820921
30MP0005409_darkened_coat_color1.75799535
31MP0009384_cardiac_valve_regurgitation1.75450788
32MP0001881_abnormal_mammary_gland1.70209593
33MP0005084_abnormal_gallbladder_morpholo1.67494540
34MP0003806_abnormal_nucleotide_metabolis1.67178515
35MP0001851_eye_inflammation1.66834376
36MP0002234_abnormal_pharynx_morphology1.65038076
37MP0010329_abnormal_lipoprotein_level1.64299173
38MP0009840_abnormal_foam_cell1.62091163
39MP0003705_abnormal_hypodermis_morpholog1.61467481
40MP0000537_abnormal_urethra_morphology1.56562851
41MP0009053_abnormal_anal_canal1.56319986
42MP0005636_abnormal_mineral_homeostasis1.56037199
43MP0002009_preneoplasia1.55265146
44MP0001873_stomach_inflammation1.54827861
45MP0005332_abnormal_amino_acid1.51429791
46MP0001663_abnormal_digestive_system1.50675679
47MP0002168_other_aberrant_phenotype1.50431436
48MP0002138_abnormal_hepatobiliary_system1.45099659
49MP0004782_abnormal_surfactant_physiolog1.44096999
50MP0002909_abnormal_adrenal_gland1.42820829
51MP0000538_abnormal_urinary_bladder1.42144374
52MP0001756_abnormal_urination1.39240973
53MP0009379_abnormal_foot_pigmentation1.39187969
54* MP0005381_digestive/alimentary_phenotyp1.38269453
55MP0005647_abnormal_sex_gland1.37102630
56* MP0000477_abnormal_intestine_morphology1.28946776
57MP0002796_impaired_skin_barrier1.28220902
58MP0010368_abnormal_lymphatic_system1.24647071
59MP0009780_abnormal_chondrocyte_physiolo1.24400088
60MP0005395_other_phenotype1.24148378
61MP0006138_congestive_heart_failure1.21545095
62MP0002166_altered_tumor_susceptibility1.21511763
63MP0005076_abnormal_cell_differentiation1.20638247
64MP0001664_abnormal_digestion1.18392847
65MP0005670_abnormal_white_adipose1.17475321
66MP0005451_abnormal_body_composition1.17380252
67MP0000678_abnormal_parathyroid_gland1.15838280
68MP0008438_abnormal_cutaneous_collagen1.13164573
69MP0010352_gastrointestinal_tract_polyps1.12575790
70MP0010155_abnormal_intestine_physiology1.11989584
71MP0002136_abnormal_kidney_physiology1.11506020
72MP0000762_abnormal_tongue_morphology1.10157270
73MP0004272_abnormal_basement_membrane1.07749991
74* MP0000163_abnormal_cartilage_morphology1.05311030
75MP0003195_calcinosis1.03148094
76MP0000490_abnormal_crypts_of1.02200929
77MP0005058_abnormal_lysosome_morphology1.02190916
78MP0000013_abnormal_adipose_tissue1.00347468
79MP0002118_abnormal_lipid_homeostasis0.99670511
80MP0004134_abnormal_chest_morphology0.99666753
81MP0002282_abnormal_trachea_morphology0.92379402
82MP0003567_abnormal_fetal_cardiomyocyte0.89918849
83MP0003953_abnormal_hormone_level0.87215103
84MP0002089_abnormal_postnatal_growth/wei0.85575942
85MP0002092_abnormal_eye_morphology0.85366141
86MP0000627_abnormal_mammary_gland0.84056289
87MP0005623_abnormal_meninges_morphology0.83492823
88MP0003566_abnormal_cell_adhesion0.83363044
89MP0000609_abnormal_liver_physiology0.82374229
90MP0003279_aneurysm0.80795311
91MP0001340_abnormal_eyelid_morphology0.80320295
92MP0001764_abnormal_homeostasis0.79927313
93* MP0002896_abnormal_bone_mineralization0.78840134
94MP0002098_abnormal_vibrissa_morphology0.78333512
95MP0003718_maternal_effect0.77566462
96MP0002006_tumorigenesis0.76637191
97* MP0002115_abnormal_skeleton_extremities0.75821180
98MP0003868_abnormal_feces_composition0.73260907
99MP0003941_abnormal_skin_development0.71941609
100MP0004484_altered_response_of0.71806017
101MP0004947_skin_inflammation0.71367958
102MP0005584_abnormal_enzyme/coenzyme_acti0.71349071
103MP0008004_abnormal_stomach_pH0.69332559
104MP0003300_gastrointestinal_ulcer0.67022464
105MP0005166_decreased_susceptibility_to0.66302673
106MP0005319_abnormal_enzyme/_coenzyme0.66013868
107MP0003828_pulmonary_edema0.65800573
108MP0004858_abnormal_nervous_system0.64441237
109MP0001849_ear_inflammation0.62497180
110MP0003632_abnormal_nervous_system0.62355194
111MP0003646_muscle_fatigue0.61625030
112MP0002254_reproductive_system_inflammat0.61208694
113MP0005501_abnormal_skin_physiology0.59127756
114MP0001529_abnormal_vocalization0.58244021
115MP0004185_abnormal_adipocyte_glucose0.57406744
116MP0000470_abnormal_stomach_morphology0.56761816
117MP0002127_abnormal_cardiovascular_syste0.56476778
118* MP0002113_abnormal_skeleton_development0.55989118
119* MP0003283_abnormal_digestive_organ0.55471006
120MP0001485_abnormal_pinna_reflex0.55015599
121MP0002933_joint_inflammation0.54713315
122MP0000613_abnormal_salivary_gland0.54533575
123MP0009697_abnormal_copulation0.53615987
124MP0002998_abnormal_bone_remodeling0.52507356
125MP0008873_increased_physiological_sensi0.52441864
126MP0010678_abnormal_skin_adnexa0.51465076
127MP0003329_amyloid_beta_deposits0.51025889
128MP0004147_increased_porphyrin_level0.50934318
129MP0001216_abnormal_epidermal_layer0.50324349
130MP0000230_abnormal_systemic_arterial0.48290614
131MP0000467_abnormal_esophagus_morphology0.47078271
132MP0009642_abnormal_blood_homeostasis0.44931094
133MP0005666_abnormal_adipose_tissue0.44900419
134MP0005310_abnormal_salivary_gland0.44678623
135* MP0003795_abnormal_bone_structure0.44194477
136MP0003879_abnormal_hair_cell0.43360679
137MP0005367_renal/urinary_system_phenotyp0.42802443
138MP0000516_abnormal_urinary_system0.42802443
139MP0003385_abnormal_body_wall0.42796699
140MP0003119_abnormal_digestive_system0.42314474
141MP0003638_abnormal_response/metabolism_0.41671493
142MP0005083_abnormal_biliary_tract0.41453820
143MP0003453_abnormal_keratinocyte_physiol0.40393280

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.00897179
2Flat acetabular roof (HP:0003180)7.53704973
3Neonatal short-limb short stature (HP:0008921)6.74648415
4Irregular epiphyses (HP:0010582)6.74240774
5Flat capital femoral epiphysis (HP:0003370)6.34108179
6Abnormal tarsal ossification (HP:0008369)6.28962067
7Flattened epiphyses (HP:0003071)4.89203879
8Hypoplasia of the uterus (HP:0000013)4.83681247
9Sex reversal (HP:0012245)4.68294272
10Abnormal sex determination (HP:0012244)4.68294272
11Premature ovarian failure (HP:0008209)4.67975497
12Nausea (HP:0002018)4.53968544
13Spinal cord compression (HP:0002176)4.50284628
14Menstrual irregularities (HP:0000858)4.45152007
15Abnormal vertebral ossification (HP:0100569)4.45074644
16Vertebral clefting (HP:0008428)4.41100604
17Abnormal foot bone ossification (HP:0010675)4.28973276
18Metaphyseal cupping (HP:0003021)4.22962743
19Osteomalacia (HP:0002749)4.12447778
20Delayed epiphyseal ossification (HP:0002663)4.10750723
21Decreased circulating renin level (HP:0003351)4.04373885
22Abnormal cartilage morphology (HP:0002763)4.04136579
23Breech presentation (HP:0001623)3.85748009
24Testicular neoplasm (HP:0010788)3.80244397
25Hip contracture (HP:0003273)3.79010554
26Germ cell neoplasia (HP:0100728)3.75277417
27Abnormality of male internal genitalia (HP:0000022)3.73690981
28* Cupped ribs (HP:0000887)3.73220641
29Protrusio acetabuli (HP:0003179)3.70043190
30Ileus (HP:0002595)3.61181533
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56381293
32Metabolic alkalosis (HP:0200114)3.53721413
33Epiphyseal dysplasia (HP:0002656)3.53487531
34Abdominal distention (HP:0003270)3.51499825
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.49766691
36Hemorrhage of the eye (HP:0011885)3.46094908
37Male infertility (HP:0003251)3.43544888
38Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.37646465
39Vertebral hypoplasia (HP:0008417)3.37646465
40Hyperpituitarism (HP:0010514)3.28602491
41* Abnormality of carpal bone ossification (HP:0006257)3.28219037
42Hyperactive renin-angiotensin system (HP:0000841)3.27423995
43* Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.27289878
44Aplasia/hypoplasia of the uterus (HP:0008684)3.15782646
45Visceral angiomatosis (HP:0100761)3.10857275
46Limited hip movement (HP:0008800)3.10367445
47Right ventricular cardiomyopathy (HP:0011663)2.99559259
48Secondary amenorrhea (HP:0000869)2.97317400
49Wrist flexion contracture (HP:0001239)2.97048911
50Posterior subcapsular cataract (HP:0007787)2.89174791
51Hemangiomatosis (HP:0007461)2.85153435
52Abnormality of chloride homeostasis (HP:0011422)2.82083174
53* Abnormality of the epiphysis of the femoral head (HP:0010574)2.79122823
54Neonatal death (HP:0003811)2.78895033
55* Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.76190761
56* Abnormality of femoral epiphyses (HP:0006499)2.76190761
57Large earlobe (HP:0009748)2.75197639
58Beaking of vertebral bodies (HP:0004568)2.74794366
59* Short middle phalanx of finger (HP:0005819)2.71849857
60Congenital sensorineural hearing impairment (HP:0008527)2.66400111
61* Abnormality of the distal phalanx of the thumb (HP:0009617)2.65022395
62Hyperaldosteronism (HP:0000859)2.64537524
63Abnormality of proline metabolism (HP:0010907)2.63919000
64Hydroxyprolinuria (HP:0003080)2.63919000
65Gout (HP:0001997)2.62405542
66Male pseudohermaphroditism (HP:0000037)2.61534439
67Osteoarthritis (HP:0002758)2.60893869
68* Genu varum (HP:0002970)2.60464916
69Stillbirth (HP:0003826)2.59386661
70Limited elbow extension (HP:0001377)2.54395586
71* Lumbar hyperlordosis (HP:0002938)2.53768170
72* Aplasia/hypoplasia of the femur (HP:0005613)2.53401191
73* Abnormal ossification of hand bones (HP:0005921)2.51851547
74Small epiphyses (HP:0010585)2.47969756
75* Symphalangism affecting the phalanges of the hand (HP:0009773)2.47916968
76* Abnormal hand bone ossification (HP:0010660)2.47480995
77Hyperglycinuria (HP:0003108)2.46303577
78* Abnormality of the femoral head (HP:0003368)2.45723028
79Platyspondyly (HP:0000926)2.44530013
80Metaphyseal irregularity (HP:0003025)2.44509735
81Hyperuricemia (HP:0002149)2.42277354
82Increased purine levels (HP:0004368)2.42277354
83Tracheal stenosis (HP:0002777)2.42112063
84Hypokalemia (HP:0002900)2.41776525
85Primary amenorrhea (HP:0000786)2.40334281
86Pili torti (HP:0003777)2.38509943
87Hypophosphatemic rickets (HP:0004912)2.38281219
88Abnormality of the vitamin B12 metabolism (HP:0004341)2.37468214
89Azoospermia (HP:0000027)2.35641120
90Malnutrition (HP:0004395)2.34599934
91Hyperphosphaturia (HP:0003109)2.31613393
92Intrahepatic cholestasis (HP:0001406)2.30167745
93Trismus (HP:0000211)2.29380547
94Infertility (HP:0000789)2.28119870
95Abnormality of purine metabolism (HP:0004352)2.26954672
96Abnormality of the acetabulum (HP:0003170)2.24607860
97Abnormality of vitamin metabolism (HP:0100508)2.22414847
98Hoarse voice (HP:0001609)2.21872992
99Abnormality of vitamin B metabolism (HP:0004340)2.21523038
100Protuberant abdomen (HP:0001538)2.19384716
101Proximal placement of thumb (HP:0009623)2.14867507
102Pigmentary retinal degeneration (HP:0001146)2.13608155
103Enlarged epiphyses (HP:0010580)2.12314292
104Septate vagina (HP:0001153)2.10975364
105Tibial bowing (HP:0002982)2.10363975
106Deviation of the thumb (HP:0009603)2.06692657
107Ventricular fibrillation (HP:0001663)2.05949170
108Glycosuria (HP:0003076)2.05010972
109Abnormality of urine glucose concentration (HP:0011016)2.05010972
110Shawl scrotum (HP:0000049)2.04646109
111Hyponatremia (HP:0002902)2.04006135
112Abnormality of renin-angiotensin system (HP:0000847)2.03699145
113Wormian bones (HP:0002645)2.03196295
114Vitreoretinal degeneration (HP:0000655)2.02699060
115Alkalosis (HP:0001948)2.02093603
116Flat face (HP:0012368)2.01065262
117Gonadotropin excess (HP:0000837)10.1138321
118Abnormal urine phosphate concentration (HP:0012599)1.99512708
119Abnormality of potassium homeostasis (HP:0011042)1.99475600
120Back pain (HP:0003418)1.99420647
121Metaphyseal dysplasia (HP:0100255)1.97797016
122* Coxa vara (HP:0002812)1.96574029
123Overgrowth (HP:0001548)1.94561317
124Hypoplastic ischia (HP:0003175)1.92536866
125Sandal gap (HP:0001852)1.91988937
126Systemic lupus erythematosus (HP:0002725)1.91308006
127Carpal bone hypoplasia (HP:0001498)1.91124325
128* Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.90820178
129Xanthomatosis (HP:0000991)1.87714112
130Hypobetalipoproteinemia (HP:0003563)1.87639716
131Late onset (HP:0003584)1.86200588
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85545196
133Abnormality of magnesium homeostasis (HP:0004921)1.85250173
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85005853
135Abnormal hair laboratory examination (HP:0003328)1.84641792
136* Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.84242462
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83648016
138Hypomagnesemia (HP:0002917)1.83215431
139Widely patent fontanelles and sutures (HP:0004492)1.82125351
140Rickets (HP:0002748)1.81289782
141Bone pain (HP:0002653)1.81171147
142* Hypoplastic ilia (HP:0000946)1.79480665
143Barrel-shaped chest (HP:0001552)1.78710390
144Wide cranial sutures (HP:0010537)1.78346295
145Villous atrophy (HP:0011473)1.77770683
146Abnormality of small intestinal villus morphology (HP:0011472)1.77770683
147Hypophosphatemia (HP:0002148)1.77275024
148Gastrointestinal dysmotility (HP:0002579)1.77224067
149High anterior hairline (HP:0009890)1.76887870
150Fat malabsorption (HP:0002630)1.76338292
151Hip dysplasia (HP:0001385)1.75621172
152Abnormal delivery (HP:0001787)1.75568720
153Rectal prolapse (HP:0002035)1.75325650
154Abnormality of calcium-phosphate metabolism (HP:0100530)1.71917859
155Arachnodactyly (HP:0001166)1.71723902
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70504779
157Nephrolithiasis (HP:0000787)1.69622732
158Primary adrenal insufficiency (HP:0008207)1.68168620
159Chronic diarrhea (HP:0002028)1.64596832
160Abnormality of alkaline phosphatase activity (HP:0004379)1.64112550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK38.42278003
2MST1R7.52674056
3PRPF4B6.79816256
4TAOK24.02825745
5EPHB23.99976559
6PIK3CA3.53202373
7ACVR1B3.28875664
8MAP2K22.72603050
9MET2.68780176
10WNK42.23876625
11RIPK12.21490008
12MAP3K122.18209059
13GRK62.17573248
14PRKG22.10887558
15MST41.98795384
16FRK1.94793611
17TAOK11.60817837
18EEF2K1.57534217
19DDR21.54804512
20SMG11.52685751
21LMTK21.50507085
22WNK31.48715866
23PTK61.45043026
24TNK21.42580875
25OXSR11.38226981
26KSR21.37581962
27CAMK1D1.31476079
28MAP3K21.26033433
29NME11.20479062
30PAK41.12043035
31CDK41.11394871
32CDK71.07633489
33EPHA21.04144952
34ARAF1.02257787
35MAP2K11.01782696
36ERN11.00675200
37PTK20.99086327
38RPS6KA20.98015975
39MAP3K110.97198138
40TESK10.92190903
41ICK0.87487886
42EPHB10.87128351
43TBK10.85574300
44MYLK0.83752077
45NME20.83496906
46RPS6KL10.81262166
47RPS6KC10.81262166
48CAMK1G0.79803068
49BCKDK0.79693811
50PIM20.78303893
51BRAF0.76760797
52CDC42BPA0.74271941
53PDPK10.72972820
54MAP3K90.72938989
55RIPK40.72061995
56ERBB40.71207735
57ERBB20.69839353
58MAP3K80.67936254
59RPS6KA60.67084573
60CAMK2D0.66144620
61PRKCI0.65721478
62MAP3K10.63465334
63RPS6KA50.63193147
64STK240.62451680
65MAP4K10.61659377
66CDK90.60773202
67MATK0.60109661
68NLK0.57990999
69PDGFRA0.57162348
70FER0.56667698
71STK390.56062874
72STK380.55759108
73KDR0.55179205
74PKN20.53076795
75MTOR0.51790506
76SIK10.50903686
77MAP2K60.50591253
78TIE10.50082975
79NEK10.48872883
80LATS10.48853077
81PDK10.48515109
82IRAK30.48209234
83FGFR40.46775822
84STK38L0.46520599
85MAP3K70.46135947
86MAP3K30.46130833
87DAPK30.45985463
88TESK20.44990205
89CSK0.44185153
90PDK20.43911572
91CSF1R0.42503864
92MAP3K100.41470448
93FGFR30.40080901
94PRKD30.38574946
95DMPK0.37643517
96MAPK110.36653411
97PTK2B0.35801817
98SRC0.35610893
99PRKCA0.34988621
100CDK30.34797574
101AKT30.30272135
102GRK10.29929315
103DYRK1B0.29747410
104PRKAA20.28299858
105STK110.25178462
106ROCK10.24606846
107CAMK2B0.24598361
108RPS6KA10.24304588
109CDK80.23972900
110LRRK20.23697832
111CAMK2G0.23439324
112STK100.23314451
113TRIB30.22787142
114TTN0.22708130
115AURKB0.22287746
116MAP3K140.21709292
117MAP3K130.21091453
118MELK0.20737756
119LIMK10.20648357
120FGFR10.20026065
121MAPK30.20010199
122GSK3A0.19815979
123MARK20.19240788
124TYRO30.19011142
125NEK20.18959833
126PRKCZ0.18666153
127RET0.18389674
128INSRR0.18108428
129TTK0.17384198
130PAK10.16998725
131IGF1R0.16161018
132MAPK10.16144916
133TGFBR10.15915077
134PRKACG0.15200066
135FGR0.14910113
136PRKCD0.14190347
137LATS20.14064275
138PRKD20.13335401
139PRKAA10.12912471

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009207.65010069
2Sulfur relay system_Homo sapiens_hsa041223.72058270
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14446138
4Mineral absorption_Homo sapiens_hsa049782.92915201
5Fat digestion and absorption_Homo sapiens_hsa049752.81551479
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59951263
7Butanoate metabolism_Homo sapiens_hsa006502.37743146
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11704732
9Bile secretion_Homo sapiens_hsa049762.05858742
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04425713
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02440132
12TGF-beta signaling pathway_Homo sapiens_hsa043501.91087362
13Vitamin digestion and absorption_Homo sapiens_hsa049771.80185669
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78017703
15Fructose and mannose metabolism_Homo sapiens_hsa000511.77640885
16Galactose metabolism_Homo sapiens_hsa000521.55777692
17Fatty acid degradation_Homo sapiens_hsa000711.53512671
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51748737
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51088569
20Tryptophan metabolism_Homo sapiens_hsa003801.47353317
21Protein digestion and absorption_Homo sapiens_hsa049741.47345924
22Renin-angiotensin system_Homo sapiens_hsa046141.45068643
23PPAR signaling pathway_Homo sapiens_hsa033201.44827697
24Starch and sucrose metabolism_Homo sapiens_hsa005001.43768995
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.43249203
26Oxidative phosphorylation_Homo sapiens_hsa001901.42253498
27Histidine metabolism_Homo sapiens_hsa003401.39171096
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34222470
29Chemical carcinogenesis_Homo sapiens_hsa052041.32753145
30Glutathione metabolism_Homo sapiens_hsa004801.29454510
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27121650
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26443864
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.26375272
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20859067
35Nitrogen metabolism_Homo sapiens_hsa009101.20220740
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11109801
37Fatty acid biosynthesis_Homo sapiens_hsa000611.09494329
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04349023
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.03714447
40Folate biosynthesis_Homo sapiens_hsa007901.03273324
41Parkinsons disease_Homo sapiens_hsa050121.02481601
42Carbon metabolism_Homo sapiens_hsa012001.01144088
43Glycerolipid metabolism_Homo sapiens_hsa005611.00647616
44Arginine biosynthesis_Homo sapiens_hsa002200.98844933
45Propanoate metabolism_Homo sapiens_hsa006400.98499289
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.97540982
47Linoleic acid metabolism_Homo sapiens_hsa005910.97537156
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96933617
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93017561
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92904212
51Pyruvate metabolism_Homo sapiens_hsa006200.92561729
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91925712
53Steroid biosynthesis_Homo sapiens_hsa001000.90425669
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88695643
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87266228
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.85910053
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84940620
58Alzheimers disease_Homo sapiens_hsa050100.84928611
59Selenocompound metabolism_Homo sapiens_hsa004500.84678604
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84247122
61Fatty acid metabolism_Homo sapiens_hsa012120.84124212
62Arginine and proline metabolism_Homo sapiens_hsa003300.81620195
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77688229
64Caffeine metabolism_Homo sapiens_hsa002320.77453314
65Peroxisome_Homo sapiens_hsa041460.77295650
66Pentose phosphate pathway_Homo sapiens_hsa000300.73932317
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.72324517
68Retinol metabolism_Homo sapiens_hsa008300.67478900
69beta-Alanine metabolism_Homo sapiens_hsa004100.67116122
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65187010
71Cardiac muscle contraction_Homo sapiens_hsa042600.62113240
72ECM-receptor interaction_Homo sapiens_hsa045120.60075466
73Arachidonic acid metabolism_Homo sapiens_hsa005900.59560751
74Tight junction_Homo sapiens_hsa045300.56699978
75Sphingolipid metabolism_Homo sapiens_hsa006000.54136139
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51811957
77Metabolic pathways_Homo sapiens_hsa011000.51706033
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.51559229
79Thyroid hormone synthesis_Homo sapiens_hsa049180.48904827
80Huntingtons disease_Homo sapiens_hsa050160.48650809
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48010867
82Pancreatic secretion_Homo sapiens_hsa049720.47728378
83Biosynthesis of amino acids_Homo sapiens_hsa012300.47162075
84Prion diseases_Homo sapiens_hsa050200.46496960
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46125994
86Phenylalanine metabolism_Homo sapiens_hsa003600.45136532
87Salivary secretion_Homo sapiens_hsa049700.44949652
88Cocaine addiction_Homo sapiens_hsa050300.42365927
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38670903
90ABC transporters_Homo sapiens_hsa020100.37607086
91Bladder cancer_Homo sapiens_hsa052190.35549818
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35333612
93Fatty acid elongation_Homo sapiens_hsa000620.33194172
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30654715
95Thyroid cancer_Homo sapiens_hsa052160.29770063
96AMPK signaling pathway_Homo sapiens_hsa041520.29380435
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28299523
98Glucagon signaling pathway_Homo sapiens_hsa049220.26392345
99Insulin resistance_Homo sapiens_hsa049310.25985743
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25400118
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.25232736
102Renin secretion_Homo sapiens_hsa049240.23501134
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.23439716
104Lysine degradation_Homo sapiens_hsa003100.23195781
105Notch signaling pathway_Homo sapiens_hsa043300.23012922
106Ovarian steroidogenesis_Homo sapiens_hsa049130.22963536
107Hepatitis C_Homo sapiens_hsa051600.22868032
108Ether lipid metabolism_Homo sapiens_hsa005650.22759047
109GnRH signaling pathway_Homo sapiens_hsa049120.22532495
110Other glycan degradation_Homo sapiens_hsa005110.21974788
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21022912
112Tyrosine metabolism_Homo sapiens_hsa003500.20530106
113Insulin signaling pathway_Homo sapiens_hsa049100.19610351
114Amoebiasis_Homo sapiens_hsa051460.18496128
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17425758
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16432775
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15767001
118Adherens junction_Homo sapiens_hsa045200.15580541
119Gastric acid secretion_Homo sapiens_hsa049710.15362801
120Complement and coagulation cascades_Homo sapiens_hsa046100.14844045
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.14803332
122Choline metabolism in cancer_Homo sapiens_hsa052310.04869777

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