IK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.57733736
2cilium movement (GO:0003341)8.98613054
3motile cilium assembly (GO:0044458)8.60695478
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.44616560
5epithelial cilium movement (GO:0003351)8.25954967
6axoneme assembly (GO:0035082)6.20331926
7regulation of cilium movement (GO:0003352)5.13370626
8mitotic sister chromatid cohesion (GO:0007064)4.97941328
9left/right pattern formation (GO:0060972)4.85483208
10intraciliary transport (GO:0042073)4.65563731
11centriole assembly (GO:0098534)4.63036048
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.47303051
13ventricular system development (GO:0021591)4.27981716
14protein localization to cilium (GO:0061512)3.95948025
15positive regulation of cell cycle checkpoint (GO:1901978)3.91813714
16left/right axis specification (GO:0070986)3.89354048
17cilium organization (GO:0044782)3.84254872
18primary alcohol catabolic process (GO:0034310)3.80653358
19tolerance induction (GO:0002507)3.76661481
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.73911659
21regulation of mitotic spindle checkpoint (GO:1903504)3.73911659
22centriole replication (GO:0007099)3.69213717
23cilium assembly (GO:0042384)3.68145085
24diterpenoid biosynthetic process (GO:0016102)3.66481778
25regulation of autophagic vacuole assembly (GO:2000785)3.64196001
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60033065
27pyrimidine-containing compound transmembrane transport (GO:0072531)3.44036638
28regulation of DNA endoreduplication (GO:0032875)3.41097603
29microtubule bundle formation (GO:0001578)3.35756405
30nuclear pore organization (GO:0006999)3.33004311
31terpenoid biosynthetic process (GO:0016114)3.32093670
32rRNA catabolic process (GO:0016075)3.30650536
33pore complex assembly (GO:0046931)3.28471965
34Golgi transport vesicle coating (GO:0048200)3.27408652
35COPI coating of Golgi vesicle (GO:0048205)3.27408652
36DNA unwinding involved in DNA replication (GO:0006268)3.24201433
37vitamin transmembrane transport (GO:0035461)3.23083809
38establishment of integrated proviral latency (GO:0075713)3.23041266
39nuclear pore complex assembly (GO:0051292)3.21627083
40sister chromatid segregation (GO:0000819)3.20763330
41DNA topological change (GO:0006265)3.17817396
42regulation of vacuole organization (GO:0044088)3.16453679
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13756737
44mitotic chromosome condensation (GO:0007076)3.11902612
45ATP synthesis coupled proton transport (GO:0015986)3.09877046
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09877046
47regulation of RNA export from nucleus (GO:0046831)3.08794214
48positive regulation of interferon-alpha production (GO:0032727)3.08083428
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07191545
50nucleoside diphosphate phosphorylation (GO:0006165)3.05818866
51response to xenobiotic stimulus (GO:0009410)3.05210442
52establishment of chromosome localization (GO:0051303)3.00699671
53alternative mRNA splicing, via spliceosome (GO:0000380)2.99728630
54metaphase plate congression (GO:0051310)2.98995940
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97003798
56microtubule depolymerization (GO:0007019)2.96801279
57cilium morphogenesis (GO:0060271)2.95881609
58regulation of microtubule-based movement (GO:0060632)2.95647684
59intra-S DNA damage checkpoint (GO:0031573)2.94748174
60mitotic metaphase plate congression (GO:0007080)2.94604871
61regulation of centriole replication (GO:0046599)2.93826863
62regulation of interferon-alpha production (GO:0032647)2.93448045
63purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.92760733
64modulation by symbiont of host immune response (GO:0052553)2.91649601
65positive regulation by symbiont of host defense response (GO:0052509)2.91649601
66modulation by symbiont of host defense response (GO:0052031)2.91649601
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91649601
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91649601
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.91649601
70proteasome assembly (GO:0043248)2.90041358
71microtubule-based movement (GO:0007018)2.88570073
72regulation of interleukin-13 production (GO:0032656)2.88561670
73regulation of nucleobase-containing compound transport (GO:0032239)2.88517664
74mitotic sister chromatid segregation (GO:0000070)2.88450998
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86264173
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86264173
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.86264173
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86233873
79negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85990028
80negative regulation of B cell mediated immunity (GO:0002713)2.85990028
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83984490
82negative regulation of T cell differentiation in thymus (GO:0033085)2.83815161
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83100341
84ethanol metabolic process (GO:0006067)2.83067588
85eosinophil chemotaxis (GO:0048245)2.81728951
86regulation of cellular amino acid metabolic process (GO:0006521)2.79914683
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78109814
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78109814
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78094237
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78094237
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78094237
92regulation of spindle organization (GO:0090224)2.77770081
93ribosome assembly (GO:0042255)2.77024676
94regulation of interferon-beta biosynthetic process (GO:0045357)2.76850660
95electron transport chain (GO:0022900)2.76536715
96DNA ligation (GO:0006266)2.76282529
97histone H2A acetylation (GO:0043968)2.75219866
98negative regulation of histone methylation (GO:0031061)2.74354325
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72846096
100respiratory electron transport chain (GO:0022904)2.71386405
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71303548
102negative regulation of ligase activity (GO:0051352)2.71303548
103signal transduction involved in DNA damage checkpoint (GO:0072422)2.70782580
104signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70782580
105cellular component assembly involved in morphogenesis (GO:0010927)2.70350755
106ATP-dependent chromatin remodeling (GO:0043044)2.70283817
107regulation of spindle checkpoint (GO:0090231)2.68840222
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68344245
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.68277434
110glucocorticoid receptor signaling pathway (GO:0042921)2.68028928
111DNA catabolic process, exonucleolytic (GO:0000738)2.67909175
112positive regulation of tolerance induction (GO:0002645)2.65305684
113mitotic nuclear envelope disassembly (GO:0007077)2.64672048
114regulation of interleukin-5 production (GO:0032674)2.64378326
115regulation of centrosome duplication (GO:0010824)2.63007360
116positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.62926146
117regulation of mitotic spindle organization (GO:0060236)2.62858940
118positive regulation of ligase activity (GO:0051351)2.62001974
119NLS-bearing protein import into nucleus (GO:0006607)2.61628630
120spliceosomal snRNP assembly (GO:0000387)2.60086199
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.59976303
122mRNA splicing, via spliceosome (GO:0000398)2.59976303
123neutrophil activation involved in immune response (GO:0002283)2.59943528
124ribosome biogenesis (GO:0042254)2.59235551
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59107815
126protein refolding (GO:0042026)2.58398234
127RNA splicing, via transesterification reactions (GO:0000375)2.56319273
128regulation of translational termination (GO:0006449)2.55938804
129rRNA modification (GO:0000154)2.55674440
130DNA deamination (GO:0045006)2.55027507
131formation of translation preinitiation complex (GO:0001731)2.54765192
132regulation of centrosome cycle (GO:0046605)2.54554177
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53836820
134attachment of spindle microtubules to kinetochore (GO:0008608)2.53490298
135regulation of T cell tolerance induction (GO:0002664)2.53049704
136regulation of NFAT protein import into nucleus (GO:0051532)2.52259431
137regulation of histone H3-K9 methylation (GO:0051570)2.52211489
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.51964469
139mRNA stabilization (GO:0048255)2.51693367
140RNA stabilization (GO:0043489)2.51693367
141regulation of sister chromatid cohesion (GO:0007063)2.50395234
142monoubiquitinated protein deubiquitination (GO:0035520)2.50231984
143negative regulation of RNA splicing (GO:0033119)2.50162748
144DNA replication-independent nucleosome organization (GO:0034724)2.49686283
145DNA replication-independent nucleosome assembly (GO:0006336)2.49686283
146ubiquinone biosynthetic process (GO:0006744)2.49392021
147sister chromatid cohesion (GO:0007062)2.49240489
148histamine secretion (GO:0001821)2.48308175
149regulation of DNA damage checkpoint (GO:2000001)2.47998069
150establishment of viral latency (GO:0019043)2.47786033
151eosinophil migration (GO:0072677)2.47448596
152regulation of MHC class II biosynthetic process (GO:0045346)2.46841146
153CENP-A containing nucleosome assembly (GO:0034080)2.45742763
154nuclear envelope disassembly (GO:0051081)2.45683393
155membrane disassembly (GO:0030397)2.45683393
156regulation of cell cycle checkpoint (GO:1901976)2.45478533
157protein localization to kinetochore (GO:0034501)2.45272404
158antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45270137
159cell projection assembly (GO:0030031)2.45006843
160positive regulation of chromosome segregation (GO:0051984)2.42843264
161DNA strand elongation involved in DNA replication (GO:0006271)2.42803706
162regulation of germinal center formation (GO:0002634)2.41784811
163aldehyde catabolic process (GO:0046185)2.41079484
164histone exchange (GO:0043486)2.40366715
165negative regulation of chromatin modification (GO:1903309)2.39323112
166kinetochore organization (GO:0051383)2.39177095
167cellular response to interferon-alpha (GO:0035457)2.39058879
168deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.38114161
1693-UTR-mediated mRNA stabilization (GO:0070935)2.37170411
170regulation of mitochondrial translation (GO:0070129)2.36258031
171telomere maintenance via semi-conservative replication (GO:0032201)2.36191873
172protein-cofactor linkage (GO:0018065)2.34812120
173tRNA aminoacylation for protein translation (GO:0006418)2.34657318
174positive regulation of histone H3-K4 methylation (GO:0051571)2.32802174
175mismatch repair (GO:0006298)2.32459605
176corticosteroid receptor signaling pathway (GO:0031958)2.32420692
177negative regulation of histone modification (GO:0031057)2.32173344
178DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.31779213
179Arp2/3 complex-mediated actin nucleation (GO:0034314)2.29850855
180negative regulation of histone acetylation (GO:0035067)2.28500063
181regulation of tolerance induction (GO:0002643)2.27424731
182regulation of mitotic metaphase/anaphase transition (GO:0030071)2.26263463
183mitotic spindle organization (GO:0007052)2.25172819
184protein localization to chromosome, centromeric region (GO:0071459)2.24946372
185positive regulation of RNA splicing (GO:0033120)2.24163435
186mitotic recombination (GO:0006312)2.23187482
187chromosome segregation (GO:0007059)2.23166381
188regulation of fibroblast apoptotic process (GO:2000269)2.21391782
189spindle assembly checkpoint (GO:0071173)2.20932789
190response to peptidoglycan (GO:0032494)2.20930952
191postreplication repair (GO:0006301)2.20659242
192resolution of meiotic recombination intermediates (GO:0000712)2.19178230
193axonemal dynein complex assembly (GO:0070286)12.1619314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98196588
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.14881531
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.11872717
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.88323807
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.48322488
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46839933
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.01265132
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96241748
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.80425949
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69189622
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.56352293
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47671207
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45098878
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42881275
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42670122
16* EST1_17652178_ChIP-ChIP_JURKAT_Human2.39602370
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.29435459
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27429032
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22964010
20* GABP_17652178_ChIP-ChIP_JURKAT_Human2.22612009
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.22448377
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16052177
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.14192371
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.13128206
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03688883
26* ELK1_19687146_ChIP-ChIP_HELA_Human2.03135562
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00843261
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99093995
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97563477
30MYC_22102868_ChIP-Seq_BL_Human1.95696788
31CIITA_25753668_ChIP-Seq_RAJI_Human1.89644946
32VDR_23849224_ChIP-Seq_CD4+_Human1.87709110
33* XRN2_22483619_ChIP-Seq_HELA_Human1.86790034
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82989907
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.82907886
36* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79711337
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78967946
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78775006
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77458261
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.76936481
41SPI1_23547873_ChIP-Seq_NB4_Human1.70417628
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.68679839
43FOXP3_21729870_ChIP-Seq_TREG_Human1.67258023
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66150525
45* YY1_21170310_ChIP-Seq_MESCs_Mouse1.66112306
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65672311
47AR_21909140_ChIP-Seq_LNCAP_Human1.63282444
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62988015
49KDM5A_27292631_Chip-Seq_BREAST_Human1.62501336
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59000066
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58757937
52DCP1A_22483619_ChIP-Seq_HELA_Human1.58665836
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58277451
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58061477
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54314620
56TTF2_22483619_ChIP-Seq_HELA_Human1.54058106
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51117125
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50869760
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49017800
60MYB_26560356_Chip-Seq_TH2_Human1.48388769
61* IRF8_27001747_Chip-Seq_BMDM_Mouse1.48169096
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.47479690
63TFEB_21752829_ChIP-Seq_HELA_Human1.46698092
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45621633
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44874297
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44599057
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44424604
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43471693
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40781805
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38953014
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38514279
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36646611
73MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30529918
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30208684
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30174602
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29942995
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28710099
78GABP_19822575_ChIP-Seq_HepG2_Human1.26154118
79* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25601657
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25223276
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24628432
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21163084
83STAT1_20625510_ChIP-Seq_HELA_Human1.20951607
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20437109
85MYC_18940864_ChIP-ChIP_HL60_Human1.19476533
86* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19351650
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18384398
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16862443
89ELF5_23300383_ChIP-Seq_T47D_Human1.15742406
90VDR_22108803_ChIP-Seq_LS180_Human1.14846651
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14485668
92IGF1R_20145208_ChIP-Seq_DFB_Human1.14432901
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13108741
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.11374931
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10621393
96SCL_19346495_ChIP-Seq_HPC-7_Human1.08999197
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08696581
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08388591
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07816505
100STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05646263
101EWS_26573619_Chip-Seq_HEK293_Human1.05259244
102VDR_21846776_ChIP-Seq_THP-1_Human1.03260207
103MYB_26560356_Chip-Seq_TH1_Human1.02786954
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02514204
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99976575
106VDR_24763502_ChIP-Seq_THP-1_Human0.98972353
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98709209
108GATA3_26560356_Chip-Seq_TH2_Human0.94508621
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94174647
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93848392
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93021585
112ZNF274_21170338_ChIP-Seq_K562_Hela0.92363364
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91728569
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91351281
115UTX_26944678_Chip-Seq_JUKART_Human0.89737103
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.88040558
117* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86839764
118GATA3_27048872_Chip-Seq_THYMUS_Human0.85836756
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83952073
120* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83148442
121BP1_19119308_ChIP-ChIP_Hs578T_Human0.82748748
122MAF_26560356_Chip-Seq_TH2_Human0.82631404
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81814291
124P300_27268052_Chip-Seq_Bcells_Human0.80977594
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80972712
126CHD1_26751641_Chip-Seq_LNCaP_Human0.80358896
127TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78875084
128TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78531748
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78481105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.39208345
2MP0003806_abnormal_nucleotide_metabolis4.37328278
3MP0000569_abnormal_digit_pigmentation4.21751750
4MP0008875_abnormal_xenobiotic_pharmacok3.77887809
5MP0003122_maternal_imprinting3.10922602
6MP0008057_abnormal_DNA_replication2.91376473
7MP0010094_abnormal_chromosome_stability2.90379807
8MP0003077_abnormal_cell_cycle2.82905179
9MP0003693_abnormal_embryo_hatching2.81572879
10MP0003121_genomic_imprinting2.81430032
11MP0008877_abnormal_DNA_methylation2.79523331
12MP0006036_abnormal_mitochondrial_physio2.69930334
13MP0003787_abnormal_imprinting2.64383758
14MP0003656_abnormal_erythrocyte_physiolo2.59853972
15MP0002277_abnormal_respiratory_mucosa2.56901115
16MP0002396_abnormal_hematopoietic_system2.51423627
17MP0001835_abnormal_antigen_presentation2.50139613
18MP0003786_premature_aging2.36034208
19MP0008007_abnormal_cellular_replicative2.20328202
20MP0001984_abnormal_olfaction2.16698242
21MP0008058_abnormal_DNA_repair2.15602861
22MP0008789_abnormal_olfactory_epithelium2.15258350
23MP0003183_abnormal_peptide_metabolism2.15104474
24MP0004147_increased_porphyrin_level2.06848898
25MP0004957_abnormal_blastocyst_morpholog2.04780620
26MP0003111_abnormal_nucleus_morphology1.95916945
27MP0002160_abnormal_reproductive_system1.90931901
28MP0008995_early_reproductive_senescence1.90554521
29MP0006035_abnormal_mitochondrial_morpho1.85027435
30MP0005076_abnormal_cell_differentiation1.72238004
31MP0004808_abnormal_hematopoietic_stem1.68624687
32MP0004043_abnormal_pH_regulation1.67334451
33MP0003436_decreased_susceptibility_to1.64033109
34MP0005671_abnormal_response_to1.62416991
35MP0006054_spinal_hemorrhage1.59148866
36MP0005000_abnormal_immune_tolerance1.58987987
37MP0001800_abnormal_humoral_immune1.57340708
38MP0005083_abnormal_biliary_tract1.57298780
39MP0002148_abnormal_hypersensitivity_rea1.56119546
40MP0002452_abnormal_antigen_presenting1.54855287
41MP0003123_paternal_imprinting1.53616835
42MP0001730_embryonic_growth_arrest1.52125879
43MP0003866_abnormal_defecation1.50973676
44MP0003718_maternal_effect1.50050187
45MP0002398_abnormal_bone_marrow1.49288343
46MP0005394_taste/olfaction_phenotype1.46117445
47MP0005499_abnormal_olfactory_system1.46117445
48MP0010030_abnormal_orbit_morphology1.42018966
49MP0000350_abnormal_cell_proliferation1.41949283
50MP0000358_abnormal_cell_content/1.36135447
51MP0002419_abnormal_innate_immunity1.35237366
52MP0005025_abnormal_response_to1.34324056
53MP0002420_abnormal_adaptive_immunity1.34298435
54MP0003172_abnormal_lysosome_physiology1.33852833
55MP0001819_abnormal_immune_cell1.33367106
56MP0002723_abnormal_immune_serum1.33027681
57MP0001853_heart_inflammation1.29811164
58MP0005636_abnormal_mineral_homeostasis1.29461858
59MP0006082_CNS_inflammation1.27575575
60MP0005389_reproductive_system_phenotype1.25992860
61MP0003698_abnormal_male_reproductive1.25973229
62MP0003890_abnormal_embryonic-extraembry1.25620096
63MP0009785_altered_susceptibility_to1.23562993
64MP0005408_hypopigmentation1.22075150
65MP0005058_abnormal_lysosome_morphology1.21522265
66MP0005387_immune_system_phenotype1.20008335
67MP0001790_abnormal_immune_system1.20008335
68MP0002405_respiratory_system_inflammati1.18040645
69MP0008932_abnormal_embryonic_tissue1.18034233
70MP0000716_abnormal_immune_system1.17186987
71MP0001346_abnormal_lacrimal_gland1.16663033
72MP0010307_abnormal_tumor_latency1.16198820
73MP0009333_abnormal_splenocyte_physiolog1.15603426
74MP0010155_abnormal_intestine_physiology1.15313017
75MP0005075_abnormal_melanosome_morpholog1.13371308
76MP0000703_abnormal_thymus_morphology1.13162040
77MP0002102_abnormal_ear_morphology1.11552579
78MP0000689_abnormal_spleen_morphology1.10751202
79MP0001727_abnormal_embryo_implantation1.10679532
80MP0000313_abnormal_cell_death1.10418013
81MP0002429_abnormal_blood_cell1.09758049
82MP0002006_tumorigenesis1.09706604
83MP0000733_abnormal_muscle_development1.09531251
84MP0001697_abnormal_embryo_size1.08748501
85MP0002234_abnormal_pharynx_morphology1.04089693
86MP0005248_abnormal_Harderian_gland1.03114694
87MP0003984_embryonic_growth_retardation1.03007322
88MP0002084_abnormal_developmental_patter1.01764250
89MP0002088_abnormal_embryonic_growth/wei1.00358878
90MP0002722_abnormal_immune_system0.99199449
91MP0001533_abnormal_skeleton_physiology0.98989287
92MP0005397_hematopoietic_system_phenotyp0.96198200
93MP0001545_abnormal_hematopoietic_system0.96198200
94MP0010352_gastrointestinal_tract_polyps0.96129418
95MP0000490_abnormal_crypts_of0.95785109
96MP0001145_abnormal_male_reproductive0.95644254
97MP0000685_abnormal_immune_system0.94476539
98MP0001672_abnormal_embryogenesis/_devel0.94060332
99MP0005380_embryogenesis_phenotype0.94060332
100MP0003303_peritoneal_inflammation0.93083101
101MP0004133_heterotaxia0.92980148
102MP0000678_abnormal_parathyroid_gland0.92387967
103MP0003448_altered_tumor_morphology0.91716392
104MP0003763_abnormal_thymus_physiology0.90122865
105MP0001293_anophthalmia0.89873778
106MP0005174_abnormal_tail_pigmentation0.88728503
107MP0001915_intracranial_hemorrhage0.88416060
108MP0002019_abnormal_tumor_incidence0.87922676
109MP0002085_abnormal_embryonic_tissue0.87460883
110MP0002080_prenatal_lethality0.87236225
111MP0000015_abnormal_ear_pigmentation0.87087544
112MP0002653_abnormal_ependyma_morphology0.87066415
113MP0000427_abnormal_hair_cycle0.86194605
114MP0005253_abnormal_eye_physiology0.86022860
115MP0004197_abnormal_fetal_growth/weight/0.85542465
116MP0000653_abnormal_sex_gland0.83604067
117MP0002166_altered_tumor_susceptibility0.81550567
118MP0009697_abnormal_copulation0.80719770
119MP0001845_abnormal_inflammatory_respons0.80280913
120MP0004381_abnormal_hair_follicle0.80278938
121MP0005310_abnormal_salivary_gland0.79313536
122MP0002210_abnormal_sex_determination0.79308763
123MP0001765_abnormal_ion_homeostasis0.78545210
124MP0003221_abnormal_cardiomyocyte_apopto0.77825304
125MP0004510_myositis0.77263161
126MP0005464_abnormal_platelet_physiology0.76764481
127MP0005384_cellular_phenotype0.75576680
128MP0005395_other_phenotype0.74575895
129MP0008873_increased_physiological_sensi0.73175577
130MP0002638_abnormal_pupillary_reflex0.73124917
131MP0000383_abnormal_hair_follicle0.72080331
132MP0002095_abnormal_skin_pigmentation0.71897527
133MP0000428_abnormal_craniofacial_morphol0.71581579
134MP0004264_abnormal_extraembryonic_tissu0.70913733
135MP0002909_abnormal_adrenal_gland0.70478614
136MP0002086_abnormal_extraembryonic_tissu0.69542612
137MP0002282_abnormal_trachea_morphology0.69238459
138MP0001529_abnormal_vocalization0.69137784
139MP0005623_abnormal_meninges_morphology0.69019582
140MP0005621_abnormal_cell_physiology0.68114913
141MP0001764_abnormal_homeostasis0.67100818
142MP0006072_abnormal_retinal_apoptosis0.66505457
143MP0009763_increased_sensitivity_to0.66128886
144MP0002161_abnormal_fertility/fecundity0.65842678
145MP0001929_abnormal_gametogenesis0.65571373
146MP0002938_white_spotting0.64908604
147MP0003186_abnormal_redox_activity0.64902600
148MP0005197_abnormal_uvea_morphology0.64655549

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.29482849
2Abnormal respiratory epithelium morphology (HP:0012253)9.29482849
3Abnormal respiratory motile cilium physiology (HP:0012261)9.10761179
4Dynein arm defect of respiratory motile cilia (HP:0012255)9.06848763
5Absent/shortened dynein arms (HP:0200106)9.06848763
6Abnormal ciliary motility (HP:0012262)8.84315132
7Rhinitis (HP:0012384)8.36844005
8Chronic bronchitis (HP:0004469)6.58275976
9Bronchiectasis (HP:0002110)6.36965127
10Nasal polyposis (HP:0100582)5.93958412
11Volvulus (HP:0002580)5.31688018
12Abnormality of the nasal mucosa (HP:0000433)4.77263974
13Chronic sinusitis (HP:0011109)3.90937967
14Bronchitis (HP:0012387)3.89059301
15Recurrent sinusitis (HP:0011108)3.86679340
16Infertility (HP:0000789)3.58293868
17Agnosia (HP:0010524)3.40645343
18Occipital encephalocele (HP:0002085)3.35349676
19Recurrent otitis media (HP:0000403)3.29167737
20Chronic otitis media (HP:0000389)3.27490657
21Degeneration of anterior horn cells (HP:0002398)3.12952453
22Abnormality of the anterior horn cell (HP:0006802)3.12952453
23Recurrent abscess formation (HP:0002722)3.10781879
24Male infertility (HP:0003251)3.08234651
25Papillary thyroid carcinoma (HP:0002895)3.02879730
26Increased nuchal translucency (HP:0010880)3.01035624
27Deep philtrum (HP:0002002)2.96340885
28Optic nerve coloboma (HP:0000588)2.69903984
29Tubular atrophy (HP:0000092)2.60340925
30Arterial tortuosity (HP:0005116)2.56976678
31Pancreatic fibrosis (HP:0100732)2.53290495
32Recurrent bacterial skin infections (HP:0005406)2.46450787
33Eczematoid dermatitis (HP:0000976)2.44530135
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.43235685
35Deviation of the thumb (HP:0009603)2.43235137
36Atelectasis (HP:0100750)2.38945157
37True hermaphroditism (HP:0010459)2.34452745
38Nephronophthisis (HP:0000090)2.31392589
39Proximal placement of thumb (HP:0009623)2.30964713
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29487198
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29487198
42Pancreatic cysts (HP:0001737)2.29485726
43Mediastinal lymphadenopathy (HP:0100721)2.28244434
44Trigonocephaly (HP:0000243)2.28233751
45Postaxial foot polydactyly (HP:0001830)2.24763452
46Broad palm (HP:0001169)2.24261876
47Optic neuritis (HP:0100653)2.23708871
48Retrobulbar optic neuritis (HP:0100654)2.23708871
49Disinhibition (HP:0000734)2.23643086
50Myositis (HP:0100614)2.23592084
51Amaurosis fugax (HP:0100576)2.21614612
52Acute necrotizing encephalopathy (HP:0006965)2.20292480
53Recurrent viral infections (HP:0004429)2.19733707
54Cutis marmorata (HP:0000965)2.17925703
55Vascular tortuosity (HP:0004948)2.15880258
56Long eyelashes (HP:0000527)2.15633206
57Abnormality of the fingertips (HP:0001211)2.14872232
58Abnormal mitochondria in muscle tissue (HP:0008316)2.14193719
59Abnormality of the labia minora (HP:0012880)2.13814375
60Medial flaring of the eyebrow (HP:0010747)2.13797516
61Mitochondrial inheritance (HP:0001427)2.12609302
62Anencephaly (HP:0002323)2.11061749
63Tubulointerstitial nephritis (HP:0001970)2.07735495
64Oculomotor apraxia (HP:0000657)2.05595999
65Failure to thrive in infancy (HP:0001531)2.05192978
66Increased cerebral lipofuscin (HP:0011813)2.01009145
67Abnormal hair whorl (HP:0010721)2.00493325
68Male pseudohermaphroditism (HP:0000037)2.00179764
69Narrow palate (HP:0000189)1.99699115
70Hepatocellular necrosis (HP:0001404)1.99289886
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97243453
72Short 4th metacarpal (HP:0010044)1.97243453
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96831315
74Increased CSF lactate (HP:0002490)1.95252968
75Increased neuronal autofluorescent lipopigment (HP:0002074)1.95159647
76Acute myeloid leukemia (HP:0004808)1.93204875
77Hyperactive renin-angiotensin system (HP:0000841)1.90805634
78Orchitis (HP:0100796)1.90550991
79Long clavicles (HP:0000890)1.90025798
80Prominent nose (HP:0000448)1.88304083
81Birth length less than 3rd percentile (HP:0003561)1.88217265
82Molar tooth sign on MRI (HP:0002419)1.87364425
83Abnormality of midbrain morphology (HP:0002418)1.87364425
84Sclerocornea (HP:0000647)1.87113284
85Thin upper lip vermilion (HP:0000219)1.86955624
86Abnormality of the renal medulla (HP:0100957)1.86709948
87Absent frontal sinuses (HP:0002688)1.86031432
88Abnormality of the intervertebral disk (HP:0005108)1.85627157
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85343698
90Papilledema (HP:0001085)1.83730902
913-Methylglutaconic aciduria (HP:0003535)1.83444052
92Selective tooth agenesis (HP:0001592)1.83403013
93Congenital hepatic fibrosis (HP:0002612)1.83364443
94Furrowed tongue (HP:0000221)1.82845171
95Thyroid carcinoma (HP:0002890)1.81944536
96Progressive macrocephaly (HP:0004481)1.81898988
97Cystic liver disease (HP:0006706)1.81588837
98Upper motor neuron abnormality (HP:0002127)1.81238660
99Congenital primary aphakia (HP:0007707)1.80415471
100Hepatic necrosis (HP:0002605)1.79313921
101Neoplasm of the oral cavity (HP:0100649)1.78139905
102Truncal obesity (HP:0001956)1.77341788
103Medulloblastoma (HP:0002885)1.76996103
104Bicuspid aortic valve (HP:0001647)1.76408495
105Cutaneous melanoma (HP:0012056)1.75625717
106Hypoplastic labia majora (HP:0000059)1.73901888
107Inappropriate behavior (HP:0000719)1.73690191
108Basal ganglia calcification (HP:0002135)1.73196539
109Severe combined immunodeficiency (HP:0004430)1.71854618
110Cellulitis (HP:0100658)1.71754185
111Acute encephalopathy (HP:0006846)1.71715623
112Urethral obstruction (HP:0000796)1.71511789
113Abnormality of cells of the erythroid lineage (HP:0012130)1.70829444
114Elevated erythrocyte sedimentation rate (HP:0003565)1.70792718
115Recurrent gram-negative bacterial infections (HP:0005420)1.70320779
116Asplenia (HP:0001746)1.69236612
117High pitched voice (HP:0001620)1.68557681
118Abnormal number of erythroid precursors (HP:0012131)1.67145996
119Abnormality of the labia majora (HP:0012881)1.66647381
120Abnormality of the renal cortex (HP:0011035)1.66578969
121Aseptic necrosis (HP:0010885)1.64747084
122Gait imbalance (HP:0002141)1.63471274
123Obstructive lung disease (HP:0006536)1.63317471
124Chronic obstructive pulmonary disease (HP:0006510)1.63317471
125Spinal cord lesions (HP:0100561)1.62751258
126Syringomyelia (HP:0003396)1.62751258
127Broad thumb (HP:0011304)1.62053008
128Obsessive-compulsive behavior (HP:0000722)1.62019920
129Myelodysplasia (HP:0002863)1.61944315
130Systemic lupus erythematosus (HP:0002725)1.61328636
131Increased intramyocellular lipid droplets (HP:0012240)1.60924400
132Prostate neoplasm (HP:0100787)1.60163729
133Osteomyelitis (HP:0002754)1.59612882
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.59522268
135Increased hepatocellular lipid droplets (HP:0006565)1.58075165
136Exercise intolerance (HP:0003546)1.58024601
137Slender long bone (HP:0003100)1.57717278
138Blepharitis (HP:0000498)1.57088064
139Ectopic kidney (HP:0000086)1.56932570
140IgM deficiency (HP:0002850)1.56754660
141Low anterior hairline (HP:0000294)1.56582255
142Chronic hepatic failure (HP:0100626)1.56310852
143Thick eyebrow (HP:0000574)1.56267008
144Growth hormone deficiency (HP:0000824)1.55058489
145Sloping forehead (HP:0000340)1.53556027
146Patellar aplasia (HP:0006443)1.53157175
147Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.52859837
148Lipid accumulation in hepatocytes (HP:0006561)1.52732748
149Recurrent bronchitis (HP:0002837)1.52653341
150Pendular nystagmus (HP:0012043)1.52286090
151Abnormal biliary tract physiology (HP:0012439)1.51823164
152Bile duct proliferation (HP:0001408)1.51823164
153Short philtrum (HP:0000322)1.50886238
154Increased serum lactate (HP:0002151)1.50355408
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50235247
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.49754076
157Combined immunodeficiency (HP:0005387)1.49032702
158Colon cancer (HP:0003003)1.48862068
159Cerebral edema (HP:0002181)1.47237328
160Aplastic anemia (HP:0001915)1.46849245
161Postaxial hand polydactyly (HP:0001162)1.45210839
162Nephrogenic diabetes insipidus (HP:0009806)1.44664298
163Nephropathy (HP:0000112)1.42685672
164Preaxial hand polydactyly (HP:0001177)1.42505262
165Increased muscle lipid content (HP:0009058)1.41902151
166Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.41419735
167Spinal muscular atrophy (HP:0007269)1.37330774
168Median cleft lip (HP:0000161)1.33906289
169Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.33672876
170Respiratory failure (HP:0002878)1.30785043
171Carpal bone hypoplasia (HP:0001498)1.30004155
172Lactic acidosis (HP:0003128)1.29551324
173Panhypogammaglobulinemia (HP:0003139)1.28581758
174Optic disc pallor (HP:0000543)1.26997397
175Abnormality of the heme biosynthetic pathway (HP:0010472)1.25898739
176Renal cortical cysts (HP:0000803)1.22549930
177Cerebral hypomyelination (HP:0006808)1.20532894
178Abnormal rod and cone electroretinograms (HP:0008323)1.20472323
179Premature ovarian failure (HP:0008209)1.19601664
180Multicystic kidney dysplasia (HP:0000003)1.17204918
181Aplasia/hypoplasia of the uterus (HP:0008684)1.17131221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.87500032
2SIK34.52833159
3CDC73.77017892
4VRK23.67451706
5STK163.05261571
6IRAK42.74146931
7NEK12.71270464
8NME12.45954595
9PBK2.39956157
10TSSK62.38171910
11CDK122.34529432
12MAP3K102.33452101
13ACVR1B2.27768006
14PASK2.25260397
15MAP4K22.17704424
16ATR2.09873922
17ERBB32.03546366
18TAOK31.89552571
19TGFBR11.73726886
20NEK21.73025615
21PLK31.71953957
22BUB11.67454999
23TLK11.66978829
24TYK21.55831332
25MAP4K11.47478695
26BCR1.47040385
27MARK31.46327204
28TBK11.45125001
29KIT1.42815311
30MKNK11.40852610
31CDK61.39696032
32RIPK41.36753966
33MAP3K121.32015633
34NME21.31967938
35EPHA21.31875921
36PNCK1.26209096
37MST41.23816790
38BRD41.21669165
39EEF2K1.19201272
40CHUK1.16565139
41PLK41.16333797
42STK101.12699194
43RPS6KA41.11984828
44TXK1.09226288
45MAPKAPK31.08712265
46TEC1.08541501
47STK31.07729048
48CLK11.07520810
49BTK1.06983473
50CHEK11.06336968
51LRRK21.05824079
52SMG11.04817558
53BRSK21.02452533
54CDK81.00883899
55CAMK1G0.99926862
56PINK10.99185292
57NUAK10.99007328
58TESK10.97967434
59RPS6KB20.97498115
60ATM0.95213870
61CCNB10.94287946
62SIK20.90998126
63PLK10.90542752
64IKBKE0.90388322
65MAP3K130.88130603
66ZAK0.87022119
67SRPK10.86482459
68CSK0.86409508
69DYRK30.86208237
70PRKCI0.85248193
71TESK20.84329786
72AURKA0.83711717
73PLK20.83015517
74AURKB0.82428750
75PDK20.81571123
76PAK40.80072986
77ZAP700.79706162
78TTK0.79469269
79JAK10.79267717
80EIF2AK30.79038658
81CDK190.78077413
82EIF2AK10.77599637
83ALK0.77149833
84CDK20.77019378
85PIM10.76511991
86JAK30.75624680
87YES10.75479009
88ITK0.74691263
89CSF1R0.74377281
90CDK10.74356412
91IRAK20.73234411
92BCKDK0.72252618
93CAMK1D0.70486608
94PIM20.70269381
95SCYL20.68041586
96STK240.65165602
97BRSK10.64420124
98IRAK30.64168708
99PRKCQ0.64147567
100ERN10.63403793
101CSNK2A20.62840775
102EPHA30.62752510
103RPS6KA50.62507321
104SYK0.62495903
105CDK40.62434223
106WEE10.61231486
107VRK10.60978287
108PTK2B0.60949204
109KDR0.60722011
110RIPK10.60695990
111MAPKAPK20.59916175
112WNK10.58076838
113MAP2K70.56486331
114CDK70.54839201
115TRPM70.53852796
116CSNK2A10.52512271
117FGFR10.51587112
118MAPK140.50417438
119ILK0.50029025
120MAPKAPK50.49658586
121GRK60.48854358
122LCK0.46514497
123ADRBK20.46288795
124UHMK10.45492571
125PRKDC0.45463213
126CSNK1E0.43520447
127BMPR1B0.42722227
128STK40.42524650
129CHEK20.42007010
130MAPK80.41997751
131NEK90.41125860
132IKBKB0.40361209
133PKN20.40306823
134MAPK90.39695334
135IRAK10.38920952
136EGFR0.37841703
137AKT10.37637690
138LYN0.37453608
139MAP3K80.36672866
140PAK10.34239451
141NLK0.30101867
142MST1R0.29873149
143RPS6KB10.25653439
144CAMKK20.25320671
145CDK90.25008379
146WNK40.25002698

Predicted pathways (KEGG)

RankGene SetZ-score
1Huntingtons disease_Homo sapiens_hsa050162.98676894
2Spliceosome_Homo sapiens_hsa030402.71346916
3Oxidative phosphorylation_Homo sapiens_hsa001902.66665561
4DNA replication_Homo sapiens_hsa030302.37843743
5Proteasome_Homo sapiens_hsa030502.27292868
6Parkinsons disease_Homo sapiens_hsa050122.25320097
7Mismatch repair_Homo sapiens_hsa034302.20832982
8Cell cycle_Homo sapiens_hsa041102.15391162
9RNA transport_Homo sapiens_hsa030132.11959730
10Non-homologous end-joining_Homo sapiens_hsa034502.09608333
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.04126506
12Leishmaniasis_Homo sapiens_hsa051401.98897508
13Antigen processing and presentation_Homo sapiens_hsa046121.91490949
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88205911
15Base excision repair_Homo sapiens_hsa034101.83649751
16Type I diabetes mellitus_Homo sapiens_hsa049401.79703861
17Legionellosis_Homo sapiens_hsa051341.79227816
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62026692
19Chemical carcinogenesis_Homo sapiens_hsa052041.60594405
20mRNA surveillance pathway_Homo sapiens_hsa030151.59697465
21Epstein-Barr virus infection_Homo sapiens_hsa051691.59611552
22Protein export_Homo sapiens_hsa030601.59546339
23Homologous recombination_Homo sapiens_hsa034401.57906413
24Phenylalanine metabolism_Homo sapiens_hsa003601.55183217
25Allograft rejection_Homo sapiens_hsa053301.53829666
26Measles_Homo sapiens_hsa051621.52115763
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51404635
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45723675
29Alzheimers disease_Homo sapiens_hsa050101.42186498
30Herpes simplex infection_Homo sapiens_hsa051681.40836517
31Osteoclast differentiation_Homo sapiens_hsa043801.39240314
32Basal transcription factors_Homo sapiens_hsa030221.37097265
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.33751761
34Glutathione metabolism_Homo sapiens_hsa004801.32624258
35Tyrosine metabolism_Homo sapiens_hsa003501.30679061
36RNA degradation_Homo sapiens_hsa030181.29776993
37Viral myocarditis_Homo sapiens_hsa054161.29403685
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28172719
39Phagosome_Homo sapiens_hsa041451.27992191
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27985902
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27252482
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27008731
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.25057255
44Hepatitis B_Homo sapiens_hsa051611.24210312
45Caffeine metabolism_Homo sapiens_hsa002321.23293482
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23129837
47Graft-versus-host disease_Homo sapiens_hsa053321.22565866
48B cell receptor signaling pathway_Homo sapiens_hsa046621.22012877
49Tuberculosis_Homo sapiens_hsa051521.21901197
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21005230
51Pertussis_Homo sapiens_hsa051331.18893190
52Purine metabolism_Homo sapiens_hsa002301.18303746
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16066075
54Salmonella infection_Homo sapiens_hsa051321.13894278
55Influenza A_Homo sapiens_hsa051641.12197767
56Rheumatoid arthritis_Homo sapiens_hsa053231.11991201
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11384134
58Nucleotide excision repair_Homo sapiens_hsa034201.10363735
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09394942
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04950720
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04560068
62HTLV-I infection_Homo sapiens_hsa051661.04285181
63Chronic myeloid leukemia_Homo sapiens_hsa052201.02754827
64Lysosome_Homo sapiens_hsa041421.02751772
65beta-Alanine metabolism_Homo sapiens_hsa004101.01372236
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00998874
67Viral carcinogenesis_Homo sapiens_hsa052031.00290690
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96289819
69Colorectal cancer_Homo sapiens_hsa052100.96020123
70Asthma_Homo sapiens_hsa053100.93629588
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92315682
72Toxoplasmosis_Homo sapiens_hsa051450.91601972
73Shigellosis_Homo sapiens_hsa051310.91265466
74Primary immunodeficiency_Homo sapiens_hsa053400.90869156
75Propanoate metabolism_Homo sapiens_hsa006400.89802540
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89692108
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88985005
78Histidine metabolism_Homo sapiens_hsa003400.88978710
79Regulation of autophagy_Homo sapiens_hsa041400.87637395
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87593714
81Pancreatic cancer_Homo sapiens_hsa052120.87341571
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86847360
83Pyruvate metabolism_Homo sapiens_hsa006200.86383193
84Selenocompound metabolism_Homo sapiens_hsa004500.84897006
85Chemokine signaling pathway_Homo sapiens_hsa040620.83494438
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83151372
87Oocyte meiosis_Homo sapiens_hsa041140.82289369
88RNA polymerase_Homo sapiens_hsa030200.82045861
89Hematopoietic cell lineage_Homo sapiens_hsa046400.81428157
90p53 signaling pathway_Homo sapiens_hsa041150.81085077
91One carbon pool by folate_Homo sapiens_hsa006700.79695972
92Apoptosis_Homo sapiens_hsa042100.79165614
93Circadian rhythm_Homo sapiens_hsa047100.78308231
94Peroxisome_Homo sapiens_hsa041460.75040900
95Butanoate metabolism_Homo sapiens_hsa006500.74890861
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73458184
97T cell receptor signaling pathway_Homo sapiens_hsa046600.69838974
98Autoimmune thyroid disease_Homo sapiens_hsa053200.69313075
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.68826973
100Malaria_Homo sapiens_hsa051440.67123006
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66821241
102Vibrio cholerae infection_Homo sapiens_hsa051100.65564183
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.65248160
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63775798
105Notch signaling pathway_Homo sapiens_hsa043300.63551943
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63181265
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63112958
108Endocytosis_Homo sapiens_hsa041440.61902407
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60616205
110Olfactory transduction_Homo sapiens_hsa047400.60278501
111Fanconi anemia pathway_Homo sapiens_hsa034600.59770426
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58896136
113Adherens junction_Homo sapiens_hsa045200.57702019
114N-Glycan biosynthesis_Homo sapiens_hsa005100.57380783
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.57060095
116Prostate cancer_Homo sapiens_hsa052150.56574200
117Metabolic pathways_Homo sapiens_hsa011000.54489680
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53929075
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.53708821
120Pyrimidine metabolism_Homo sapiens_hsa002400.53191315
121TNF signaling pathway_Homo sapiens_hsa046680.52854790
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52495649
123MicroRNAs in cancer_Homo sapiens_hsa052060.51465041
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51098234
125Retinol metabolism_Homo sapiens_hsa008300.51080886
126Proteoglycans in cancer_Homo sapiens_hsa052050.49688581
127Renal cell carcinoma_Homo sapiens_hsa052110.49320404
128Staphylococcus aureus infection_Homo sapiens_hsa051500.46101948
129Carbon metabolism_Homo sapiens_hsa012000.45736643
130Hepatitis C_Homo sapiens_hsa051600.45634225
131HIF-1 signaling pathway_Homo sapiens_hsa040660.44799428
132Collecting duct acid secretion_Homo sapiens_hsa049660.43816054
133Non-small cell lung cancer_Homo sapiens_hsa052230.43342989
134Pathways in cancer_Homo sapiens_hsa052000.42539181
135Ribosome_Homo sapiens_hsa030100.41838806
136Small cell lung cancer_Homo sapiens_hsa052220.41121065
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37939442
138Cardiac muscle contraction_Homo sapiens_hsa042600.37627656
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.36905997
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34048503
141Phototransduction_Homo sapiens_hsa047440.33389499
142Fructose and mannose metabolism_Homo sapiens_hsa000510.32269873
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29077978
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26713051
145Fatty acid elongation_Homo sapiens_hsa000620.20493007
146Pentose phosphate pathway_Homo sapiens_hsa000300.18040253
147Biosynthesis of amino acids_Homo sapiens_hsa012300.15874152
148Linoleic acid metabolism_Homo sapiens_hsa005910.15472215

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