IKBKAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)5.55456224
2nuclear pore organization (GO:0006999)5.03673611
3nuclear pore complex assembly (GO:0051292)4.98334028
4negative regulation of fibrinolysis (GO:0051918)4.86664289
5plasma lipoprotein particle assembly (GO:0034377)4.85915920
6DNA unwinding involved in DNA replication (GO:0006268)4.72417565
7pre-miRNA processing (GO:0031054)4.56329366
8Golgi transport vesicle coating (GO:0048200)4.42966474
9COPI coating of Golgi vesicle (GO:0048205)4.42966474
10protein-lipid complex assembly (GO:0065005)4.31439475
11regulation of fibrinolysis (GO:0051917)4.13510899
12protein localization to kinetochore (GO:0034501)4.04866822
13regulation of protein activation cascade (GO:2000257)4.03675588
14intestinal cholesterol absorption (GO:0030299)4.01970395
15regulation of complement activation (GO:0030449)3.94979925
16peptidyl-arginine omega-N-methylation (GO:0035247)3.94333806
17positive regulation of dendritic spine morphogenesis (GO:0061003)3.92807759
18COPII vesicle coating (GO:0048208)3.85979930
19regulation of apoptotic cell clearance (GO:2000425)3.81781833
20DNA replication-dependent nucleosome assembly (GO:0006335)3.78638685
21DNA replication-dependent nucleosome organization (GO:0034723)3.78638685
22protein carboxylation (GO:0018214)3.77553150
23peptidyl-glutamic acid carboxylation (GO:0017187)3.77553150
24peptidyl-arginine methylation (GO:0018216)3.73038681
25peptidyl-arginine N-methylation (GO:0035246)3.73038681
26pore complex assembly (GO:0046931)3.69760731
27mitotic chromosome condensation (GO:0007076)3.69537270
28proline biosynthetic process (GO:0006561)3.69480411
29mitotic nuclear envelope disassembly (GO:0007077)3.68290350
30sister chromatid segregation (GO:0000819)3.59447392
31negative regulation of histone methylation (GO:0031061)3.59248655
32regulation of cholesterol biosynthetic process (GO:0045540)3.59157065
33IMP biosynthetic process (GO:0006188)3.56944079
34membrane disassembly (GO:0030397)3.55576182
35nuclear envelope disassembly (GO:0051081)3.55576182
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51205685
37low-density lipoprotein particle remodeling (GO:0034374)3.48473966
38mitotic metaphase plate congression (GO:0007080)3.43873848
39DNA geometric change (GO:0032392)3.43227816
40DNA duplex unwinding (GO:0032508)3.43120815
41histone arginine methylation (GO:0034969)3.40937489
42regulation of posttranscriptional gene silencing (GO:0060147)3.40062540
43regulation of gene silencing by miRNA (GO:0060964)3.40062540
44regulation of gene silencing by RNA (GO:0060966)3.40062540
45mitotic sister chromatid segregation (GO:0000070)3.34786295
46cholesterol efflux (GO:0033344)3.34174656
47mitotic sister chromatid cohesion (GO:0007064)3.30389989
48positive regulation of hormone biosynthetic process (GO:0046886)3.27991645
49regulation of histone H3-K9 methylation (GO:0051570)3.27270626
50layer formation in cerebral cortex (GO:0021819)3.25399615
51paraxial mesoderm development (GO:0048339)3.23822684
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21754607
53regulation of cholesterol homeostasis (GO:2000188)3.19701110
54DNA replication initiation (GO:0006270)3.19215819
55plasma lipoprotein particle organization (GO:0071827)3.16517802
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14634626
57folic acid-containing compound biosynthetic process (GO:0009396)3.13788960
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.13322272
59kinetochore organization (GO:0051383)3.12325002
60regulation of centriole replication (GO:0046599)3.12129460
61nucleobase biosynthetic process (GO:0046112)3.11567321
62proline metabolic process (GO:0006560)3.11360235
63regulation of spindle organization (GO:0090224)3.11125406
64regulation of cholesterol esterification (GO:0010872)3.10363020
65protein localization to chromosome, centromeric region (GO:0071459)3.10163929
66embryonic retina morphogenesis in camera-type eye (GO:0060059)3.08276227
67metaphase plate congression (GO:0051310)3.08020719
68blood coagulation, intrinsic pathway (GO:0007597)3.07061971
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04464932
70spliceosomal tri-snRNP complex assembly (GO:0000244)3.04420647
71regulation of RNA export from nucleus (GO:0046831)3.01800737
72regulation of translational fidelity (GO:0006450)3.01224680
73plasma lipoprotein particle remodeling (GO:0034369)2.99217814
74protein-lipid complex remodeling (GO:0034368)2.99217814
75macromolecular complex remodeling (GO:0034367)2.99217814
76regulation of helicase activity (GO:0051095)2.98270909
77protein-lipid complex subunit organization (GO:0071825)2.97069930
78negative regulation of protein activation cascade (GO:2000258)2.97049343
79protein retention in ER lumen (GO:0006621)2.96522238
80regulation of sister chromatid cohesion (GO:0007063)2.96425622
81IMP metabolic process (GO:0046040)2.95362888
82somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95220548
83somatic hypermutation of immunoglobulin genes (GO:0016446)2.95220548
84DNA topological change (GO:0006265)2.94561983
85negative regulation of chromosome segregation (GO:0051985)2.93959970
86DNA strand elongation involved in DNA replication (GO:0006271)2.93390266
87peptidyl-lysine dimethylation (GO:0018027)2.91961966
88histone H2A monoubiquitination (GO:0035518)2.91772328
89positive regulation of cell cycle checkpoint (GO:1901978)2.91611756
90spindle assembly checkpoint (GO:0071173)2.91133864
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90767592
92negative regulation of sister chromatid segregation (GO:0033046)2.90767592
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.90767592
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90767592
95vesicle coating (GO:0006901)2.90704076
96regulation of nucleobase-containing compound transport (GO:0032239)2.90160364
97regulation of mitotic spindle organization (GO:0060236)2.89878554
98regulation of centrosome cycle (GO:0046605)2.89002928
99spindle checkpoint (GO:0031577)2.87864347
100dosage compensation (GO:0007549)2.87858717
101mitotic spindle assembly checkpoint (GO:0007094)2.87550110
102chromatin remodeling at centromere (GO:0031055)2.87103323
103regulation of bile acid biosynthetic process (GO:0070857)2.85990998
104mitotic spindle checkpoint (GO:0071174)2.85343944
105heterochromatin organization (GO:0070828)2.84098318
106regulation of chromosome segregation (GO:0051983)2.83771827
107DNA strand elongation (GO:0022616)2.82632361
108DNA replication-independent nucleosome organization (GO:0034724)2.82155677
109DNA replication-independent nucleosome assembly (GO:0006336)2.82155677
110chromatin assembly or disassembly (GO:0006333)2.81857742
111positive regulation of chromosome segregation (GO:0051984)2.81600479
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80780097
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80669623
114positive regulation of hormone metabolic process (GO:0032352)2.79463023
115response to follicle-stimulating hormone (GO:0032354)2.79396645
116CENP-A containing nucleosome assembly (GO:0034080)2.79106578
117chromatin assembly (GO:0031497)2.78581891
118regulation of plasminogen activation (GO:0010755)2.77312713
119negative regulation of DNA repair (GO:0045738)2.76909199
120regulation of mitotic sister chromatid separation (GO:0010965)2.74992165
121regulation of mitotic sister chromatid segregation (GO:0033047)2.74992165
122regulation of sister chromatid segregation (GO:0033045)2.74992165
123negative regulation of RNA splicing (GO:0033119)2.74557273
124dicarboxylic acid biosynthetic process (GO:0043650)2.74317537
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73204109
126DNA conformation change (GO:0071103)2.72661758
127regulation of DNA damage checkpoint (GO:2000001)2.72307118
128attachment of spindle microtubules to kinetochore (GO:0008608)2.72071152
129nuclear envelope organization (GO:0006998)2.70773170
130histone H4-K8 acetylation (GO:0043982)2.70150544
131histone H4-K5 acetylation (GO:0043981)2.70150544
132establishment of chromosome localization (GO:0051303)2.69068566
133histone exchange (GO:0043486)2.68023243
134low-density lipoprotein particle clearance (GO:0034383)2.67698660
135ATP-dependent chromatin remodeling (GO:0043044)2.67553699
136glutamate metabolic process (GO:0006536)2.67161782
137regulation of translational termination (GO:0006449)2.66863278
138mRNA transport (GO:0051028)2.65111926
139regulation of centrosome duplication (GO:0010824)2.63948334
140purine nucleobase biosynthetic process (GO:0009113)2.63377562
141RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.63050517
142mRNA splicing, via spliceosome (GO:0000398)2.63050517
143regulation of telomere maintenance via telomerase (GO:0032210)2.62432542
144formation of translation preinitiation complex (GO:0001731)2.62274413
145negative regulation of histone modification (GO:0031057)2.61821925
146lung epithelium development (GO:0060428)2.56849322
147high-density lipoprotein particle remodeling (GO:0034375)2.54204673
148regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50624139
149plasma lipoprotein particle clearance (GO:0034381)2.49856993
150long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.48379945
151regulation of cholesterol metabolic process (GO:0090181)2.48363935
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47679292
153L-phenylalanine metabolic process (GO:0006558)2.47679292
154intestinal absorption (GO:0050892)2.46701163
155neurotransmitter-gated ion channel clustering (GO:0072578)2.42755378
156stress granule assembly (GO:0034063)2.42111719
157protein export from nucleus (GO:0006611)2.40915197
158positive regulation of nuclease activity (GO:0032075)2.40418146
159activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39900583
160fatty acid homeostasis (GO:0055089)2.38919860
161negative regulation of complement activation (GO:0045916)2.36828128
162C21-steroid hormone metabolic process (GO:0008207)2.36586339
163biotin metabolic process (GO:0006768)2.36468428
164reverse cholesterol transport (GO:0043691)2.33255602
165positive regulation of synapse maturation (GO:0090129)2.32625492
166ribosome assembly (GO:0042255)2.32470283
167chromosome condensation (GO:0030261)2.32347130
1684-hydroxyproline metabolic process (GO:0019471)2.32092691
169G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.30918109
170cholesterol biosynthetic process (GO:0006695)2.30068439
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.29806699
172L-phenylalanine catabolic process (GO:0006559)2.29806699
173positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29638278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.44179614
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.02160694
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10862449
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.79159153
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.36067536
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.21803149
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.13757627
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92635647
9ZNF263_19887448_ChIP-Seq_K562_Human2.83384608
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81477720
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80831570
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.73668375
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73330996
14CLOCK_20551151_ChIP-Seq_293T_Human2.60339026
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48264935
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35996816
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30556151
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.19088462
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16368008
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15131333
21* FOXA2_19822575_ChIP-Seq_HepG2_Human2.11848932
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.10000097
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09636290
24XRN2_22483619_ChIP-Seq_HELA_Human2.03619995
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03097122
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93700704
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93505378
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88834279
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.87432664
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86604561
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83974692
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.82520311
33AR_21909140_ChIP-Seq_LNCAP_Human1.80440220
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76416066
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76066520
36CIITA_25753668_ChIP-Seq_RAJI_Human1.72299840
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69626264
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69155060
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.69000488
40MYC_22102868_ChIP-Seq_BL_Human1.67459562
41SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.65743008
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65530006
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62121641
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.61432818
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60275770
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59533164
47TTF2_22483619_ChIP-Seq_HELA_Human1.56646460
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55466505
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54250461
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53515425
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51317309
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51169975
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49317341
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45800257
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.45611058
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44262604
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43986446
58SOX17_20123909_ChIP-Seq_XEN_Mouse1.41310508
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40519987
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39647091
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39616419
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39380733
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37684597
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.34478589
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33853921
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32432201
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31686497
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.29309732
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29240758
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28016939
71TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.26399716
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26179268
73ELK1_19687146_ChIP-ChIP_HELA_Human1.25474278
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24413606
75KDM5A_27292631_Chip-Seq_BREAST_Human1.23427154
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23052934
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21263794
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21092348
79VDR_23849224_ChIP-Seq_CD4+_Human1.19403027
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18804895
81FOXP3_21729870_ChIP-Seq_TREG_Human1.18475412
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18252963
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17642127
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16851712
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16506757
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16506757
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16506757
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.16243055
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15429230
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15213650
91* GABP_19822575_ChIP-Seq_HepG2_Human1.15193122
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15175597
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13518961
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13291832
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13166696
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12002762
97TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11377635
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.10692274
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09703314
100* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09288823
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08037758
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07402008
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07119881
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.06218380
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05943669
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05920692
107PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05765328
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04078878
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02632540
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02390587
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02137416
112DCP1A_22483619_ChIP-Seq_HELA_Human1.02095351
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01260426
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.01162112
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01160374
116CHD1_26751641_Chip-Seq_LNCaP_Human0.99975708
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99970915
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99438466
119* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98586213
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98260623
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98108730
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97382894
123LXR_22158963_ChIP-Seq_LIVER_Mouse0.97277704
124* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96562985
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96283886
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96072963
127EZH2_22144423_ChIP-Seq_EOC_Human0.95649136
128* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95276358
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95010993
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91141844
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89959919
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87375332
133POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86283206
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86250020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.56030857
2MP0010094_abnormal_chromosome_stability3.12088212
3MP0003111_abnormal_nucleus_morphology3.02594039
4MP0003121_genomic_imprinting2.87106803
5MP0008057_abnormal_DNA_replication2.85747758
6MP0004957_abnormal_blastocyst_morpholog2.79416894
7MP0003077_abnormal_cell_cycle2.67823015
8MP0003693_abnormal_embryo_hatching2.67704991
9MP0010030_abnormal_orbit_morphology2.43913382
10MP0003122_maternal_imprinting2.30518581
11MP0000537_abnormal_urethra_morphology2.29876742
12MP0008877_abnormal_DNA_methylation2.23174762
13MP0003890_abnormal_embryonic-extraembry2.18907476
14MP0008058_abnormal_DNA_repair2.14536519
15MP0001661_extended_life_span2.12750646
16MP0003787_abnormal_imprinting2.12564647
17MP0001915_intracranial_hemorrhage2.11784052
18MP0010352_gastrointestinal_tract_polyps2.00601185
19MP0005409_darkened_coat_color1.96826241
20MP0000569_abnormal_digit_pigmentation1.95752483
21* MP0001730_embryonic_growth_arrest1.89912962
22MP0008932_abnormal_embryonic_tissue1.87507251
23MP0000350_abnormal_cell_proliferation1.83047050
24MP0005076_abnormal_cell_differentiation1.81221547
25MP0008007_abnormal_cellular_replicative1.77944077
26* MP0002084_abnormal_developmental_patter1.77153035
27MP0006292_abnormal_olfactory_placode1.76117253
28MP0002139_abnormal_hepatobiliary_system1.73522433
29MP0004859_abnormal_synaptic_plasticity1.73005984
30MP0003868_abnormal_feces_composition1.71468953
31MP0003119_abnormal_digestive_system1.71262180
32MP0004197_abnormal_fetal_growth/weight/1.67820417
33* MP0002085_abnormal_embryonic_tissue1.65663802
34MP0009053_abnormal_anal_canal1.65029534
35MP0005365_abnormal_bile_salt1.63279712
36MP0005408_hypopigmentation1.61698504
37MP0001293_anophthalmia1.59870148
38MP0001672_abnormal_embryogenesis/_devel1.58303589
39MP0005380_embryogenesis_phenotype1.58303589
40MP0001666_abnormal_nutrient_absorption1.57960310
41* MP0001697_abnormal_embryo_size1.57786065
42MP0009697_abnormal_copulation1.46985302
43* MP0003861_abnormal_nervous_system1.46377745
44MP0002089_abnormal_postnatal_growth/wei1.45942536
45MP0010329_abnormal_lipoprotein_level1.44499086
46MP0003283_abnormal_digestive_organ1.43755205
47MP0010307_abnormal_tumor_latency1.41824834
48MP0003984_embryonic_growth_retardation1.41792574
49MP0002088_abnormal_embryonic_growth/wei1.40307154
50MP0005394_taste/olfaction_phenotype1.37322842
51MP0005499_abnormal_olfactory_system1.37322842
52MP0004272_abnormal_basement_membrane1.36709444
53MP0000428_abnormal_craniofacial_morphol1.36257996
54MP0000778_abnormal_nervous_system1.35176881
55* MP0003937_abnormal_limbs/digits/tail_de1.34175684
56* MP0002080_prenatal_lethality1.32788967
57MP0009780_abnormal_chondrocyte_physiolo1.31791309
58MP0004133_heterotaxia1.30061688
59* MP0002086_abnormal_extraembryonic_tissu1.29506029
60MP0008789_abnormal_olfactory_epithelium1.28492298
61MP0003566_abnormal_cell_adhesion1.26549011
62MP0004233_abnormal_muscle_weight1.24929459
63MP0000639_abnormal_adrenal_gland1.24284713
64MP0003943_abnormal_hepatobiliary_system1.22467473
65MP0005451_abnormal_body_composition1.21129902
66MP0001346_abnormal_lacrimal_gland1.20201144
67MP0003385_abnormal_body_wall1.19776691
68MP0005623_abnormal_meninges_morphology1.19101577
69MP0002909_abnormal_adrenal_gland1.17867817
70MP0003567_abnormal_fetal_cardiomyocyte1.17283897
71MP0002751_abnormal_autonomic_nervous1.16788199
72MP0009703_decreased_birth_body1.13639599
73MP0004264_abnormal_extraembryonic_tissu1.13579609
74MP0003755_abnormal_palate_morphology1.13545804
75MP0002009_preneoplasia1.13294198
76MP0005360_urolithiasis1.12316152
77MP0000566_synostosis1.12058663
78MP0009672_abnormal_birth_weight1.09672799
79MP0001529_abnormal_vocalization1.07964026
80MP0002184_abnormal_innervation1.07436044
81MP0003942_abnormal_urinary_system1.07092760
82MP0003950_abnormal_plasma_membrane1.06311248
83* MP0003935_abnormal_craniofacial_develop1.06200312
84MP0000049_abnormal_middle_ear1.04853600
85MP0002697_abnormal_eye_size1.03245748
86MP0003705_abnormal_hypodermis_morpholog1.03041565
87MP0010368_abnormal_lymphatic_system1.02244958
88MP0003115_abnormal_respiratory_system1.01761396
89MP0003315_abnormal_perineum_morphology1.01574893
90MP0002160_abnormal_reproductive_system1.00146289
91MP0002938_white_spotting0.98806798
92MP0002111_abnormal_tail_morphology0.98690121
93MP0005257_abnormal_intraocular_pressure0.97885858
94MP0008260_abnormal_autophagy0.97628885
95MP0004811_abnormal_neuron_physiology0.96670142
96MP0002081_perinatal_lethality0.96591274
97MP0003938_abnormal_ear_development0.95737603
98MP0005220_abnormal_exocrine_pancreas0.94953623
99MP0002116_abnormal_craniofacial_bone0.94339830
100* MP0002152_abnormal_brain_morphology0.94310750
101MP0001299_abnormal_eye_distance/0.93422907
102MP0002269_muscular_atrophy0.92561753
103MP0001286_abnormal_eye_development0.92395553
104MP0002653_abnormal_ependyma_morphology0.91621699
105MP0005248_abnormal_Harderian_gland0.91363949
106MP0004185_abnormal_adipocyte_glucose0.90431635
107MP0005187_abnormal_penis_morphology0.89956464
108MP0002233_abnormal_nose_morphology0.89626435
109MP0002114_abnormal_axial_skeleton0.89551217
110MP0000631_abnormal_neuroendocrine_gland0.89132801
111MP0003635_abnormal_synaptic_transmissio0.87029420
112MP0004808_abnormal_hematopoietic_stem0.86759254
113MP0000534_abnormal_ureter_morphology0.86199644
114MP0000432_abnormal_head_morphology0.85902856
115MP0002092_abnormal_eye_morphology0.85490664
116MP0010630_abnormal_cardiac_muscle0.82509620
117MP0004270_analgesia0.82419453
118MP0000003_abnormal_adipose_tissue0.82256559
119MP0003329_amyloid_beta_deposits0.81573391
120MP0000955_abnormal_spinal_cord0.81248477
121MP0003221_abnormal_cardiomyocyte_apopto0.81168957
122MP0002932_abnormal_joint_morphology0.79953296
123MP0002234_abnormal_pharynx_morphology0.79591046
124MP0005384_cellular_phenotype0.79456553
125MP0003786_premature_aging0.78685047
126MP0000313_abnormal_cell_death0.77839693
127MP0002063_abnormal_learning/memory/cond0.76900720
128MP0002210_abnormal_sex_determination0.75513794
129MP0002249_abnormal_larynx_morphology0.74277966
130MP0003195_calcinosis0.73508461
131MP0003941_abnormal_skin_development0.73459566
132MP0000733_abnormal_muscle_development0.72497956
133MP0001270_distended_abdomen0.72249822
134MP0003632_abnormal_nervous_system0.71380624
135* MP0002925_abnormal_cardiovascular_devel0.71191781
136MP0001145_abnormal_male_reproductive0.71043126
137MP0000609_abnormal_liver_physiology0.70989281
138MP0000762_abnormal_tongue_morphology0.70755268
139MP0000598_abnormal_liver_morphology0.70460890
140MP0008770_decreased_survivor_rate0.69471046
141MP0010234_abnormal_vibrissa_follicle0.69315262
142MP0006072_abnormal_retinal_apoptosis0.68972979
143MP0002877_abnormal_melanocyte_morpholog0.67640200

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.02856454
2Prolonged partial thromboplastin time (HP:0003645)4.23115512
3Hypobetalipoproteinemia (HP:0003563)4.11999885
4Abnormality of the labia minora (HP:0012880)4.11833161
5Abnormality of the common coagulation pathway (HP:0010990)3.55968009
6Ependymoma (HP:0002888)3.55102229
7Colon cancer (HP:0003003)3.41076204
8Short 4th metacarpal (HP:0010044)3.35035270
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.35035270
10Asymmetry of the thorax (HP:0001555)3.31940519
11Small epiphyses (HP:0010585)3.28839662
12Abnormality of carpal bone ossification (HP:0006257)3.20811532
13Flat acetabular roof (HP:0003180)3.17571328
14Astrocytoma (HP:0009592)3.15657296
15Abnormality of the astrocytes (HP:0100707)3.15657296
16Hypercholesterolemia (HP:0003124)3.09915981
17Overlapping toe (HP:0001845)3.00408096
18Medulloblastoma (HP:0002885)3.00015617
19Abnormality of glycolysis (HP:0004366)2.94492225
20Abnormal tarsal ossification (HP:0008369)2.91529559
21Hypoplasia of the capital femoral epiphysis (HP:0003090)2.89455880
22Acanthocytosis (HP:0001927)2.83474390
23Shoulder girdle muscle weakness (HP:0003547)2.77622687
24Increased serum pyruvate (HP:0003542)2.75978708
25Facial hemangioma (HP:0000329)2.68506082
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.66881554
27Pancreatic islet-cell hyperplasia (HP:0004510)2.63762320
28Joint hemorrhage (HP:0005261)2.63668870
29Pelvic girdle muscle weakness (HP:0003749)2.60992975
30Glioma (HP:0009733)2.57972135
31Renal duplication (HP:0000075)2.56655951
32Abnormal ossification of hand bones (HP:0005921)2.51584481
33Hypolipoproteinemia (HP:0010981)2.47204549
34Abnormal foot bone ossification (HP:0010675)2.45763342
35Abnormal number of incisors (HP:0011064)2.44053120
36Insidious onset (HP:0003587)2.43368243
37Termporal pattern (HP:0011008)2.43368243
38Increased nuchal translucency (HP:0010880)2.43366671
39Absent epiphyses (HP:0010577)2.40327447
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40327447
41Complement deficiency (HP:0004431)2.34390358
42Abnormal hand bone ossification (HP:0010660)2.33988514
43Selective tooth agenesis (HP:0001592)2.33044273
44Abnormality of the 4th metacarpal (HP:0010012)2.31838861
45Epidermoid cyst (HP:0200040)2.31170395
46Abnormality of the musculature of the pelvis (HP:0001469)2.29539603
47Abnormality of the hip-girdle musculature (HP:0001445)2.29539603
48Limited elbow extension (HP:0001377)2.25440824
49Wide nose (HP:0000445)2.24432763
50Diastasis recti (HP:0001540)2.23275749
51Hepatoblastoma (HP:0002884)2.18332153
52Scanning speech (HP:0002168)2.17512701
53Rhabdomyosarcoma (HP:0002859)2.16039261
54Missing ribs (HP:0000921)2.13865841
55Patellar aplasia (HP:0006443)2.11729611
56Spontaneous abortion (HP:0005268)2.11142737
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10382090
58Ankyloglossia (HP:0010296)2.10231337
59Hyperacusis (HP:0010780)2.10143686
60Vaginal fistula (HP:0004320)2.10118561
61Abnormality of the pancreatic islet cells (HP:0006476)2.08337173
62Abnormality of endocrine pancreas physiology (HP:0012093)2.08337173
63Volvulus (HP:0002580)2.07896347
64Shallow orbits (HP:0000586)2.07400650
65Mitral stenosis (HP:0001718)2.07122535
66Menorrhagia (HP:0000132)2.06746090
67Abnormal lung lobation (HP:0002101)2.04977903
68Pointed chin (HP:0000307)2.02303815
69Progressive external ophthalmoplegia (HP:0000590)2.01440136
70Chromsome breakage (HP:0040012)2.00677467
71* Impaired pain sensation (HP:0007328)1.99182418
72* Abnormality of pain sensation (HP:0010832)1.99182418
73Neoplasm of the oral cavity (HP:0100649)1.97407595
74Carpal bone hypoplasia (HP:0001498)1.97350161
75Aplasia/Hypoplasia of the patella (HP:0006498)1.97029230
76Neoplasm of striated muscle (HP:0009728)1.95472978
77Back pain (HP:0003418)1.94703786
78Trigonocephaly (HP:0000243)1.92175939
79Deviation of the thumb (HP:0009603)1.92045843
80Broad thumb (HP:0011304)1.92011571
81Short 1st metacarpal (HP:0010034)1.91372607
82Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.91372607
83Hemorrhage of the eye (HP:0011885)1.91370891
84Abnormality of the lower motor neuron (HP:0002366)1.91223102
85Proximal placement of thumb (HP:0009623)1.90988294
86Renovascular hypertension (HP:0100817)1.88238511
87Epiphyseal dysplasia (HP:0002656)1.88133898
88Hypoglycemic coma (HP:0001325)1.87645781
89Abnormal connection of the cardiac segments (HP:0011545)1.87468186
90Abnormal ventriculo-arterial connection (HP:0011563)1.87468186
91Transposition of the great arteries (HP:0001669)1.87468186
92Vertebral arch anomaly (HP:0008438)1.87027101
93Abnormality of the acetabulum (HP:0003170)1.86597510
94Agnosia (HP:0010524)1.85250724
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84064708
96Increased density of long bones (HP:0006392)1.84042323
97Septate vagina (HP:0001153)1.83699593
98Spinal muscular atrophy (HP:0007269)1.83478477
99Submucous cleft hard palate (HP:0000176)1.83325270
100Atresia of the external auditory canal (HP:0000413)1.82657679
101Gastrointestinal carcinoma (HP:0002672)1.82131246
102Malignant gastrointestinal tract tumors (HP:0006749)1.82131246
103Thyroid carcinoma (HP:0002890)1.81865751
104Protrusio acetabuli (HP:0003179)1.81665996
105Elfin facies (HP:0004428)1.81549890
106Ectopic kidney (HP:0000086)1.81545985
107Meckel diverticulum (HP:0002245)1.79523141
108Abnormality of the metopic suture (HP:0005556)1.79416274
109Irregular epiphyses (HP:0010582)1.78898626
110Atrophy/Degeneration involving motor neurons (HP:0007373)1.78227289
111Abnormality of the anterior horn cell (HP:0006802)1.78224505
112Degeneration of anterior horn cells (HP:0002398)1.78224505
113Benign neoplasm of the central nervous system (HP:0100835)1.76994504
114Cortical dysplasia (HP:0002539)1.76612743
115Oligodactyly (HP:0012165)1.75827182
116Birth length less than 3rd percentile (HP:0003561)1.75813236
117Hypoglycemic seizures (HP:0002173)1.75135963
118Abnormality of chromosome stability (HP:0003220)1.75116259
119Abnormality of the lumbar spine (HP:0100712)1.75055195
120Broad phalanges of the hand (HP:0009768)1.74843179
121Heterotopia (HP:0002282)1.74494497
122Nephroblastoma (Wilms tumor) (HP:0002667)1.74072989
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.74029992
12411 pairs of ribs (HP:0000878)1.73575887
125Amyotrophic lateral sclerosis (HP:0007354)1.73143507
126Cholecystitis (HP:0001082)1.72881066
127Abnormal gallbladder physiology (HP:0012438)1.72881066
128Anal stenosis (HP:0002025)1.72659759
129Xanthomatosis (HP:0000991)1.72658732
130Abnormality of the ileum (HP:0001549)1.72559862
131Obsessive-compulsive behavior (HP:0000722)1.71546055
132Embryonal neoplasm (HP:0002898)1.71393301
133Dislocated radial head (HP:0003083)1.70948949
134Bowel diverticulosis (HP:0005222)1.70786258
135Rhizomelia (HP:0008905)1.70638560
136Abnormality of the diencephalon (HP:0010662)1.70038490
137Absent radius (HP:0003974)1.70035793
138Bifid scrotum (HP:0000048)1.69677901
139Overriding aorta (HP:0002623)1.69583007
140Cupped ribs (HP:0000887)1.69454532
141Papillary thyroid carcinoma (HP:0002895)1.68984697
142Glomerulonephritis (HP:0000099)1.68243834
143Skin nodule (HP:0200036)1.67682951
144Abnormality of the intrinsic pathway (HP:0010989)1.67631036
145Self-mutilation (HP:0000742)1.67563814
146Embryonal renal neoplasm (HP:0011794)1.67470246
147Facial cleft (HP:0002006)1.66971655
148Cafe-au-lait spot (HP:0000957)1.66604326
149Abnormality of the nasal septum (HP:0000419)1.64474869
150Rib fusion (HP:0000902)1.64449622
151Abnormality of the carotid arteries (HP:0005344)1.64257699
152Broad finger (HP:0001500)1.63819751
153Broad palm (HP:0001169)1.62415164
154Abnormality of complement system (HP:0005339)1.61233737
155Absent forearm bone (HP:0003953)1.61002032
156Aplasia involving forearm bones (HP:0009822)1.61002032
157Megalocornea (HP:0000485)1.60999340
158Broad alveolar ridges (HP:0000187)1.60592968
159Intestinal polyposis (HP:0200008)1.60312161
160Dysmetric saccades (HP:0000641)1.60181244
161Basal cell carcinoma (HP:0002671)1.60004052
162Aqueductal stenosis (HP:0002410)1.59918604
163Supernumerary spleens (HP:0009799)1.59472970
164Skull defect (HP:0001362)1.59441926
165Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59215938
166Insomnia (HP:0100785)1.59022758
167Duodenal stenosis (HP:0100867)1.58902063
168Small intestinal stenosis (HP:0012848)1.58902063
169Biliary tract neoplasm (HP:0100574)1.58537518
170Intestinal polyp (HP:0005266)1.58259773
171Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.57349378
172Hypoplastic labia majora (HP:0000059)1.57278477
173Uterine leiomyosarcoma (HP:0002891)1.56311706
174Leiomyosarcoma (HP:0100243)1.56311706
175Neoplasm of the pancreas (HP:0002894)1.55561962
176Long clavicles (HP:0000890)1.55290286
177Abnormality of the calcaneus (HP:0008364)1.55255983
178Malignant neoplasm of the central nervous system (HP:0100836)1.55177454
179Freckling (HP:0001480)1.54491070
180Tracheoesophageal fistula (HP:0002575)1.54228721
181Abnormality of the lacrimal duct (HP:0011481)1.53543942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.36436621
2FGFR43.76951063
3TSSK62.90061120
4NEK12.86645361
5CDK122.83077074
6BUB12.81725871
7WEE12.64002645
8FGFR32.60781449
9PNCK2.51901191
10MARK12.36235155
11KSR12.26182344
12SRPK12.21059362
13NEK22.09540996
14PLK32.00233350
15PASK1.94452079
16TTK1.83975659
17TRIB31.76702885
18MKNK11.75845480
19ALK1.75497494
20WNK41.71662420
21MAP3K41.71501067
22NTRK31.70374509
23EEF2K1.61854621
24PLK11.59938785
25BRD41.59323408
26LATS21.58746531
27ATR1.55363878
28RIPK11.55059517
29SCYL21.54278710
30TLK11.51951345
31CHEK11.43485855
32RPS6KB21.39596502
33MAPKAPK51.38829288
34CHEK21.32122677
35SMG11.28986443
36FGFR21.28973580
37ERBB31.27187704
38PKN21.24380886
39WNK11.22161228
40CAMK1G1.18948026
41AURKB1.18654849
42MAP3K91.15768185
43CAMK1D1.15258905
44MAP3K101.14689090
45PDK21.14678773
46MKNK21.13468554
47CCNB11.12347334
48MINK11.11242122
49CDK71.10424418
50TGFBR11.10402093
51CDK21.07630310
52PBK1.07114738
53ATM1.02893004
54PAK41.02276085
55DAPK11.02233378
56PLK21.00619194
57FGFR10.97081456
58LATS10.96102747
59BRSK10.95677479
60NTRK10.94577257
61CDK10.94253716
62VRK10.92280009
63ACVR1B0.92155789
64AURKA0.91057110
65MAP3K20.90879539
66MTOR0.90221627
67MST1R0.89674266
68MELK0.87683589
69EPHA20.87043421
70BRSK20.85573378
71CSNK1E0.85507050
72CDK40.84340471
73PLK40.83832677
74DYRK30.83749033
75MAP3K80.82413243
76EIF2AK10.79943690
77PRKCI0.76298611
78CSNK1A1L0.75960484
79UHMK10.72881683
80NTRK20.72677430
81NEK60.72030556
82MET0.71669513
83DYRK20.71500135
84SIK20.70706678
85PDGFRA0.69891145
86AKT30.69768156
87PRKDC0.69622287
88MAPK130.69452776
89PRKD30.68932248
90PAK60.65814931
91ERBB40.65205228
92CDK180.64885984
93CDK60.64648945
94STK390.63512506
95DYRK1B0.63233738
96YES10.61523266
97CDK150.61197576
98CSNK1D0.60774298
99CDK140.59121522
100ZAK0.58429826
101TTN0.57955523
102BCR0.57221524
103PRKAA20.56720378
104PRKAA10.55706656
105AKT20.55559886
106PAK20.55057661
107EPHA40.53689399
108CSNK2A20.53578838
109SGK30.53455674
110MAPK140.53342374
111ICK0.53314798
112MAPK110.53144761
113CDK11A0.52595460
114RPS6KB10.52224831
115DAPK20.52049939
116GSK3B0.51293011
117SGK2230.51204140
118SGK4940.51204140
119EIF2AK30.50806444
120PIK3CA0.48703096
121MAP2K70.48611169
122TYRO30.47568218
123PTK20.45787782
124MAPK100.45652841
125PDGFRB0.45608248
126SGK10.45486670
127LIMK10.45436209
128NEK90.43537628
129KSR20.43290666
130CSNK1G30.38856411
131CSNK1G20.38726165
132RAF10.37734487
133WNK30.37477251
134MAPK90.36541132
135MAPK80.36026343
136RET0.32231518

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22779679
2Mismatch repair_Homo sapiens_hsa034303.09635358
3DNA replication_Homo sapiens_hsa030302.98605625
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97535370
5Spliceosome_Homo sapiens_hsa030402.90208301
6RNA transport_Homo sapiens_hsa030132.89400995
7Complement and coagulation cascades_Homo sapiens_hsa046102.61813933
8Steroid biosynthesis_Homo sapiens_hsa001002.60503767
9Cell cycle_Homo sapiens_hsa041102.48029428
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35832911
11mRNA surveillance pathway_Homo sapiens_hsa030152.26225251
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17692516
13One carbon pool by folate_Homo sapiens_hsa006702.17472838
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04843256
15Fatty acid biosynthesis_Homo sapiens_hsa000611.98191338
16Base excision repair_Homo sapiens_hsa034101.94095110
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89696111
18Nucleotide excision repair_Homo sapiens_hsa034201.89175559
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86268812
20Biosynthesis of amino acids_Homo sapiens_hsa012301.84757398
21Homologous recombination_Homo sapiens_hsa034401.78400998
22Oocyte meiosis_Homo sapiens_hsa041141.78060242
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74856755
24Fatty acid metabolism_Homo sapiens_hsa012121.69269295
25Fanconi anemia pathway_Homo sapiens_hsa034601.69006092
26Systemic lupus erythematosus_Homo sapiens_hsa053221.61998758
27Non-homologous end-joining_Homo sapiens_hsa034501.61873397
28RNA polymerase_Homo sapiens_hsa030201.61687893
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61503502
30Vitamin B6 metabolism_Homo sapiens_hsa007501.60507406
31RNA degradation_Homo sapiens_hsa030181.59711356
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59662925
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55967028
34Arginine biosynthesis_Homo sapiens_hsa002201.51217468
35Basal cell carcinoma_Homo sapiens_hsa052171.45918885
36Pyruvate metabolism_Homo sapiens_hsa006201.45478777
37Alcoholism_Homo sapiens_hsa050341.44827059
38Lysine degradation_Homo sapiens_hsa003101.43669103
39Carbon metabolism_Homo sapiens_hsa012001.40534385
40N-Glycan biosynthesis_Homo sapiens_hsa005101.40182695
41Hippo signaling pathway_Homo sapiens_hsa043901.39202647
42Colorectal cancer_Homo sapiens_hsa052101.34806542
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33463241
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33383196
45Hedgehog signaling pathway_Homo sapiens_hsa043401.26565266
46MicroRNAs in cancer_Homo sapiens_hsa052061.25524088
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20626004
48Viral carcinogenesis_Homo sapiens_hsa052031.18210422
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17738236
50mTOR signaling pathway_Homo sapiens_hsa041501.13786774
51Basal transcription factors_Homo sapiens_hsa030221.12459291
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10522869
53p53 signaling pathway_Homo sapiens_hsa041151.08766838
54Fat digestion and absorption_Homo sapiens_hsa049751.06966218
55Wnt signaling pathway_Homo sapiens_hsa043101.06034618
56Long-term potentiation_Homo sapiens_hsa047201.05903279
57Proteasome_Homo sapiens_hsa030501.04325153
58Phenylalanine metabolism_Homo sapiens_hsa003601.02357514
59Propanoate metabolism_Homo sapiens_hsa006401.02291847
60Pyrimidine metabolism_Homo sapiens_hsa002401.02167472
61Nicotine addiction_Homo sapiens_hsa050331.01781948
62Epstein-Barr virus infection_Homo sapiens_hsa051690.98041023
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97034116
64Fatty acid degradation_Homo sapiens_hsa000710.96848417
65HTLV-I infection_Homo sapiens_hsa051660.96355822
66Endometrial cancer_Homo sapiens_hsa052130.96161157
67Ribosome_Homo sapiens_hsa030100.94621407
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.92863455
69TGF-beta signaling pathway_Homo sapiens_hsa043500.90729280
70Glioma_Homo sapiens_hsa052140.85403179
71Axon guidance_Homo sapiens_hsa043600.85357452
72Synaptic vesicle cycle_Homo sapiens_hsa047210.85332486
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85152472
74Thyroid hormone synthesis_Homo sapiens_hsa049180.83144052
75Chronic myeloid leukemia_Homo sapiens_hsa052200.83129487
76Thyroid cancer_Homo sapiens_hsa052160.82728733
77Adherens junction_Homo sapiens_hsa045200.81118903
78Gap junction_Homo sapiens_hsa045400.80680912
79Other glycan degradation_Homo sapiens_hsa005110.79841053
80Vitamin digestion and absorption_Homo sapiens_hsa049770.79542858
81Dopaminergic synapse_Homo sapiens_hsa047280.78083186
82Non-small cell lung cancer_Homo sapiens_hsa052230.77037461
83Arginine and proline metabolism_Homo sapiens_hsa003300.76507030
84Notch signaling pathway_Homo sapiens_hsa043300.76471645
85Prion diseases_Homo sapiens_hsa050200.76214424
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.75738050
87Fatty acid elongation_Homo sapiens_hsa000620.73667870
88AMPK signaling pathway_Homo sapiens_hsa041520.73611718
89Melanogenesis_Homo sapiens_hsa049160.73067763
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.71555354
91Bile secretion_Homo sapiens_hsa049760.71303321
92ErbB signaling pathway_Homo sapiens_hsa040120.70361799
93Estrogen signaling pathway_Homo sapiens_hsa049150.70167614
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69075444
95Proteoglycans in cancer_Homo sapiens_hsa052050.68078538
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67815596
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67155582
98Tight junction_Homo sapiens_hsa045300.66373745
99PPAR signaling pathway_Homo sapiens_hsa033200.66155856
100Amphetamine addiction_Homo sapiens_hsa050310.65461182
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64802448
102Viral myocarditis_Homo sapiens_hsa054160.64326336
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64223598
104Melanoma_Homo sapiens_hsa052180.63725862
105Long-term depression_Homo sapiens_hsa047300.63350955
106Bladder cancer_Homo sapiens_hsa052190.63326852
107ABC transporters_Homo sapiens_hsa020100.63076011
108ECM-receptor interaction_Homo sapiens_hsa045120.62967772
109Histidine metabolism_Homo sapiens_hsa003400.62899510
110Pathways in cancer_Homo sapiens_hsa052000.62103942
111Circadian entrainment_Homo sapiens_hsa047130.60185123
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59802674
113Renal cell carcinoma_Homo sapiens_hsa052110.59109024
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58784892
115Vibrio cholerae infection_Homo sapiens_hsa051100.58312601
116Starch and sucrose metabolism_Homo sapiens_hsa005000.58275280
117Type II diabetes mellitus_Homo sapiens_hsa049300.58217406
118Small cell lung cancer_Homo sapiens_hsa052220.57936716
119Selenocompound metabolism_Homo sapiens_hsa004500.57886484
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57480022
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56491808
122Purine metabolism_Homo sapiens_hsa002300.56345422
123Pentose phosphate pathway_Homo sapiens_hsa000300.54489642
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53857325
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53520839
126HIF-1 signaling pathway_Homo sapiens_hsa040660.53226767
127MAPK signaling pathway_Homo sapiens_hsa040100.51944313
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51146696
129Tyrosine metabolism_Homo sapiens_hsa003500.51121594
130Oxytocin signaling pathway_Homo sapiens_hsa049210.50323809
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49580638
132Prostate cancer_Homo sapiens_hsa052150.49071053
133Choline metabolism in cancer_Homo sapiens_hsa052310.49037630
134Cholinergic synapse_Homo sapiens_hsa047250.48490463
135Glutamatergic synapse_Homo sapiens_hsa047240.47650272
136Focal adhesion_Homo sapiens_hsa045100.47394176
137Inositol phosphate metabolism_Homo sapiens_hsa005620.46804010
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46481213
139Renin-angiotensin system_Homo sapiens_hsa046140.46267260
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45818568
141GnRH signaling pathway_Homo sapiens_hsa049120.45670495
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.44888966
143Type I diabetes mellitus_Homo sapiens_hsa049400.44600092
144Pancreatic cancer_Homo sapiens_hsa052120.43967481
145FoxO signaling pathway_Homo sapiens_hsa040680.43819760
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.43772319
147Fructose and mannose metabolism_Homo sapiens_hsa000510.43375153
148Rap1 signaling pathway_Homo sapiens_hsa040150.42545668
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42226487
150Galactose metabolism_Homo sapiens_hsa000520.41405611
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39588596
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39542691
153Cocaine addiction_Homo sapiens_hsa050300.39271708
154GABAergic synapse_Homo sapiens_hsa047270.38979831
155Insulin signaling pathway_Homo sapiens_hsa049100.38317166
156Morphine addiction_Homo sapiens_hsa050320.38156821
157Herpes simplex infection_Homo sapiens_hsa051680.36790267
158Olfactory transduction_Homo sapiens_hsa047400.36683444
159Glucagon signaling pathway_Homo sapiens_hsa049220.36654995

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