IKBKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.18916701
2antigen processing and presentation of endogenous antigen (GO:0019883)5.45133418
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26941446
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.26941446
5NIK/NF-kappaB signaling (GO:0038061)4.64248297
6regulation of gamma-delta T cell differentiation (GO:0045586)4.53958405
7regulation of gamma-delta T cell activation (GO:0046643)4.49971946
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47488569
9negative thymic T cell selection (GO:0045060)4.46646219
10negative T cell selection (GO:0043383)4.41804250
11regulation of B cell receptor signaling pathway (GO:0050855)4.27958391
12negative regulation of cell killing (GO:0031342)4.21490084
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.21490084
14regulation of interleukin-12 biosynthetic process (GO:0045075)4.19372948
15positive thymic T cell selection (GO:0045059)4.05508796
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.03935130
17T cell migration (GO:0072678)3.98845323
18detection of other organism (GO:0098543)3.88051812
19detection of bacterium (GO:0016045)3.84659429
20positive regulation of B cell differentiation (GO:0045579)3.84347496
21negative regulation of erythrocyte differentiation (GO:0045647)3.79595145
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.74161374
23regulation of B cell differentiation (GO:0045577)3.73378751
24response to muramyl dipeptide (GO:0032495)3.63336934
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.61314729
26B cell receptor signaling pathway (GO:0050853)3.56545513
27thymic T cell selection (GO:0045061)3.55475918
28T cell selection (GO:0045058)3.49640870
29negative regulation of T cell mediated immunity (GO:0002710)3.48929930
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48647692
31positive T cell selection (GO:0043368)3.46122226
32interferon-gamma production (GO:0032609)3.45832560
33response to interleukin-15 (GO:0070672)3.42790884
34germinal center formation (GO:0002467)3.42362394
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.40605754
36positive regulation of antigen processing and presentation (GO:0002579)3.40191752
37regulation of alpha-beta T cell proliferation (GO:0046640)3.39985572
38positive regulation of humoral immune response (GO:0002922)3.36732355
39response to type I interferon (GO:0034340)3.33121753
40negative regulation of leukocyte mediated immunity (GO:0002704)3.32058124
41regulation of T cell tolerance induction (GO:0002664)3.27884736
42type I interferon signaling pathway (GO:0060337)3.27526475
43cellular response to type I interferon (GO:0071357)3.27526475
44positive regulation of granulocyte differentiation (GO:0030854)3.27234518
45neutrophil activation involved in immune response (GO:0002283)3.26566975
46mature B cell differentiation (GO:0002335)3.25162760
47leukocyte aggregation (GO:0070486)3.24736513
48myeloid dendritic cell activation (GO:0001773)3.22641006
49detection of external biotic stimulus (GO:0098581)3.21555626
50regulation of interferon-beta biosynthetic process (GO:0045357)3.20372117
51positive regulation of interferon-alpha production (GO:0032727)3.19442127
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18354739
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18354739
54positive regulation by organism of defense response of other organism involved in symbiotic interact3.18354739
55modulation by symbiont of host immune response (GO:0052553)3.18354739
56positive regulation by symbiont of host defense response (GO:0052509)3.18354739
57modulation by symbiont of host defense response (GO:0052031)3.18354739
58positive regulation of interleukin-2 production (GO:0032743)3.16429535
59cellular response to interleukin-15 (GO:0071350)3.15226062
60tolerance induction (GO:0002507)3.14431137
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11296922
62neutrophil activation (GO:0042119)3.10630537
63positive regulation of natural killer cell differentiation (GO:0032825)3.09805703
64interferon-gamma-mediated signaling pathway (GO:0060333)3.09781019
65regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09316414
66regulation of interferon-alpha production (GO:0032647)3.02808545
67JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02722903
68regulation of T cell mediated cytotoxicity (GO:0001914)2.99864768
69immunoglobulin mediated immune response (GO:0016064)2.96027645
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93101722
71regulation of natural killer cell mediated immunity (GO:0002715)2.93101722
72regulation of mast cell degranulation (GO:0043304)2.92619088
73myeloid dendritic cell differentiation (GO:0043011)2.91280932
74regulation of antigen processing and presentation (GO:0002577)2.88909401
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88893067
76granulocyte activation (GO:0036230)2.88020953
77microglial cell activation (GO:0001774)2.87769021
78defense response to protozoan (GO:0042832)2.87636491
79positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86917987
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86747954
81negative regulation of innate immune response (GO:0045824)2.86371775
82detection of biotic stimulus (GO:0009595)2.81457537
83regulation of regulatory T cell differentiation (GO:0045589)2.80675047
84detection of molecule of bacterial origin (GO:0032490)2.80531391
85regulation of T cell receptor signaling pathway (GO:0050856)2.80093777
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80011791
87negative regulation of T-helper cell differentiation (GO:0045623)2.80011791
88mannose metabolic process (GO:0006013)2.79682452
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.78200013
90regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76943727
91T-helper 1 type immune response (GO:0042088)2.76428640
92macrophage activation involved in immune response (GO:0002281)2.76232826
93* antigen receptor-mediated signaling pathway (GO:0050851)2.75871961
94activated T cell proliferation (GO:0050798)2.75587612
95positive regulation of interleukin-12 production (GO:0032735)2.73056116
96T cell homeostasis (GO:0043029)2.72924514
97macrophage activation (GO:0042116)2.71340360
98leukocyte cell-cell adhesion (GO:0007159)2.71080951
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70579881
100regulation of granulocyte differentiation (GO:0030852)2.68648359
101mast cell activation (GO:0045576)2.68594028
102cellular response to zinc ion (GO:0071294)2.67712758
103T-helper cell differentiation (GO:0042093)2.67669982
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.67669982
105positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.67642270
106cellular extravasation (GO:0045123)2.67583783
107regulation of mast cell activation involved in immune response (GO:0033006)2.67310399
108Peyers patch development (GO:0048541)2.67177706
109mucosal-associated lymphoid tissue development (GO:0048537)2.67177706
110B cell proliferation (GO:0042100)2.66542012
111response to protozoan (GO:0001562)2.66538308
112positive regulation of tolerance induction (GO:0002645)2.65786644
113regulation of mast cell activation (GO:0033003)2.65111293
114natural killer cell activation (GO:0030101)2.64969465
115regulation of leukocyte degranulation (GO:0043300)2.64398279
116myeloid cell activation involved in immune response (GO:0002275)2.64114047
117lymph node development (GO:0048535)2.63266052
118respiratory burst (GO:0045730)2.62089057
119regulation of B cell proliferation (GO:0030888)2.61148421
120negative regulation of interleukin-12 production (GO:0032695)2.60340902
121regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60339582
122T cell costimulation (GO:0031295)2.59227560
123regulation of necroptotic process (GO:0060544)2.59182014
124regulation of tolerance induction (GO:0002643)2.58839297
125positive regulation of B cell proliferation (GO:0030890)2.58088593
126response to peptidoglycan (GO:0032494)2.57051861
127* lymphocyte homeostasis (GO:0002260)2.57004759
128positive regulation of B cell activation (GO:0050871)2.56833082
129positive regulation of cytokine biosynthetic process (GO:0042108)2.56579205
130antigen processing and presentation via MHC class Ib (GO:0002475)2.55525004
131cellular response to interferon-beta (GO:0035458)2.55287096
132cellular response to exogenous dsRNA (GO:0071360)2.55238071
133lymphocyte costimulation (GO:0031294)2.54672555
134regulation of interleukin-12 production (GO:0032655)2.54114349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.17591293
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.97116596
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.80925387
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.28663258
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.07967348
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.04310713
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.34533885
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31838139
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27974609
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20059392
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.18760626
12RUNX_20019798_ChIP-Seq_JUKART_Human3.09656920
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88596854
14SCL_19346495_ChIP-Seq_HPC-7_Human2.76451342
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.72249110
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65327018
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52163706
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41278602
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.40562966
20* MYB_26560356_Chip-Seq_TH2_Human2.38311588
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24826387
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22020709
23MYB_26560356_Chip-Seq_TH1_Human2.19719920
24* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18547631
25MAF_26560356_Chip-Seq_TH1_Human2.13433532
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08331535
27MYC_22102868_ChIP-Seq_BL_Human1.96468597
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88495005
29* VDR_21846776_ChIP-Seq_THP-1_Human1.88360553
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85016086
31* SPI1_23547873_ChIP-Seq_NB4_Human1.79527656
32* VDR_24763502_ChIP-Seq_THP-1_Human1.77858573
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71893585
34UTX_26944678_Chip-Seq_JUKART_Human1.70314034
35GATA1_22025678_ChIP-Seq_K562_Human1.69810478
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.68750656
37TCF7_22412390_ChIP-Seq_EML_Mouse1.64635396
38SPI1_23127762_ChIP-Seq_K562_Human1.62665343
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61706169
40PU_27001747_Chip-Seq_BMDM_Mouse1.61563046
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.56316436
42GATA3_27048872_Chip-Seq_THYMUS_Human1.55674356
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53936717
44VDR_24787735_ChIP-Seq_THP-1_Human1.53636392
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.53169825
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50669799
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49908964
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48363800
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47801625
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43567781
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.39733315
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39237329
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38751436
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37051847
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35697324
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.34957408
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34934740
58LXR_22292898_ChIP-Seq_THP-1_Human1.34751568
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32742119
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30436256
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29919308
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28635070
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28585864
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27895506
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.23572612
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21640047
67MAF_26560356_Chip-Seq_TH2_Human1.20613449
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.18644310
69* GATA3_26560356_Chip-Seq_TH2_Human1.16523973
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16090352
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13421854
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12334153
73* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12132929
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11785579
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11622175
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10551277
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07246097
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06707876
79KDM2B_26808549_Chip-Seq_DND41_Human1.06168977
80CIITA_25753668_ChIP-Seq_RAJI_Human1.03905853
81* BCOR_27268052_Chip-Seq_Bcells_Human1.03535420
82* BCL6_27268052_Chip-Seq_Bcells_Human1.03063489
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01726612
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99955184
85GATA2_19941826_ChIP-Seq_K562_Human0.96030446
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95393537
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.93528351
88CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92091822
89NCOR1_26117541_ChIP-Seq_K562_Human0.90251413
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89689735
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89291251
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88447091
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.87577988
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.85924576
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.84901917
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83616919
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83583739
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83200790
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82908863
100RACK7_27058665_Chip-Seq_MCF-7_Human0.82152052
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82098117
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.81483450
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80073116
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79525217
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79522281
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79077038
107GATA1_19941826_ChIP-Seq_K562_Human0.77864225
108TP63_17297297_ChIP-ChIP_HaCaT_Human0.76005472
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75909602
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72987778
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72701687
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72573064
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.69697751
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69236698
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68322354
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.67359549
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64610632
118* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64209544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35258653
2MP0000685_abnormal_immune_system3.56211282
3MP0005387_immune_system_phenotype3.32113692
4MP0001790_abnormal_immune_system3.32113692
5* MP0001800_abnormal_humoral_immune3.13176372
6MP0005671_abnormal_response_to3.06601242
7MP0005000_abnormal_immune_tolerance2.84441049
8MP0003436_decreased_susceptibility_to2.81780506
9MP0003763_abnormal_thymus_physiology2.71966397
10* MP0002452_abnormal_antigen_presenting2.70590660
11MP0009785_altered_susceptibility_to2.67307793
12* MP0002723_abnormal_immune_serum2.61725065
13MP0002166_altered_tumor_susceptibility2.57316099
14MP0002148_abnormal_hypersensitivity_rea2.56479383
15MP0005025_abnormal_response_to2.53198093
16* MP0002419_abnormal_innate_immunity2.51008280
17* MP0002420_abnormal_adaptive_immunity2.46184039
18* MP0001819_abnormal_immune_cell2.45393514
19MP0000569_abnormal_digit_pigmentation2.41840030
20MP0002138_abnormal_hepatobiliary_system2.37763093
21MP0002396_abnormal_hematopoietic_system2.22086437
22MP0004510_myositis2.18234685
23MP0002006_tumorigenesis2.16344526
24MP0002398_abnormal_bone_marrow2.11109842
25MP0001873_stomach_inflammation2.08728227
26MP0006082_CNS_inflammation2.07464136
27MP0001853_heart_inflammation2.06253530
28MP0005464_abnormal_platelet_physiology2.05226587
29* MP0000716_abnormal_immune_system2.01984488
30MP0003724_increased_susceptibility_to1.98993584
31MP0003303_peritoneal_inflammation1.95647845
32MP0002405_respiratory_system_inflammati1.92216135
33MP0004947_skin_inflammation1.91488992
34MP0003300_gastrointestinal_ulcer1.89720686
35MP0002254_reproductive_system_inflammat1.89564224
36MP0000689_abnormal_spleen_morphology1.75796505
37* MP0010155_abnormal_intestine_physiology1.74878865
38* MP0001845_abnormal_inflammatory_respons1.72246302
39MP0005174_abnormal_tail_pigmentation1.67179715
40MP0002722_abnormal_immune_system1.66546085
41MP0005451_abnormal_body_composition1.65909435
42* MP0002429_abnormal_blood_cell1.61440465
43MP0005310_abnormal_salivary_gland1.57923770
44MP0002132_abnormal_respiratory_system1.41967435
45* MP0008469_abnormal_protein_level1.41878236
46MP0009764_decreased_sensitivity_to1.40850505
47MP0000703_abnormal_thymus_morphology1.39365125
48MP0001533_abnormal_skeleton_physiology1.34747309
49MP0003172_abnormal_lysosome_physiology1.33084760
50MP0002933_joint_inflammation1.30464837
51MP0003183_abnormal_peptide_metabolism1.29423017
52MP0009333_abnormal_splenocyte_physiolog1.29218325
53MP0009278_abnormal_bone_marrow1.25247646
54MP0003191_abnormal_cellular_cholesterol1.25150347
55MP0004808_abnormal_hematopoietic_stem1.25130774
56MP0005360_urolithiasis1.23926662
57MP0002009_preneoplasia1.20609972
58MP0004381_abnormal_hair_follicle1.17348650
59MP0001545_abnormal_hematopoietic_system1.16086519
60MP0005397_hematopoietic_system_phenotyp1.16086519
61MP0000465_gastrointestinal_hemorrhage1.15688719
62MP0005058_abnormal_lysosome_morphology1.12205378
63MP0003866_abnormal_defecation1.11705990
64MP0003252_abnormal_bile_duct1.10486601
65MP0002998_abnormal_bone_remodeling1.08917781
66MP0000858_altered_metastatic_potential1.08187459
67MP0005075_abnormal_melanosome_morpholog1.06746165
68MP0003448_altered_tumor_morphology1.04867599
69MP0002139_abnormal_hepatobiliary_system1.04488638
70MP0005365_abnormal_bile_salt1.03274515
71MP0009763_increased_sensitivity_to1.01862754
72MP0004883_abnormal_blood_vessel1.01077623
73MP0002928_abnormal_bile_duct0.99703647
74MP0002277_abnormal_respiratory_mucosa0.98575117
75MP0003690_abnormal_glial_cell0.98396679
76MP0000371_diluted_coat_color0.97744500
77MP0001986_abnormal_taste_sensitivity0.96596909
78MP0000015_abnormal_ear_pigmentation0.92229179
79MP0004130_abnormal_muscle_cell0.88521498
80* MP0000609_abnormal_liver_physiology0.87147704
81MP0002136_abnormal_kidney_physiology0.85521255
82MP0003453_abnormal_keratinocyte_physiol0.84502764
83MP0003045_fibrosis0.84464426
84MP0003279_aneurysm0.83967690
85MP0001851_eye_inflammation0.82855944
86MP0009840_abnormal_foam_cell0.81766571
87MP0003656_abnormal_erythrocyte_physiolo0.81408673
88MP0001958_emphysema0.81204868
89MP0003075_altered_response_to0.79223020
90MP0000249_abnormal_blood_vessel0.72547047
91MP0003091_abnormal_cell_migration0.71230588
92MP0003646_muscle_fatigue0.70871297
93MP0005390_skeleton_phenotype0.70791775
94MP0009765_abnormal_xenobiotic_induced0.68950045
95MP0005166_decreased_susceptibility_to0.68938627
96MP0001348_abnormal_lacrimal_gland0.68492450
97MP0005085_abnormal_gallbladder_physiolo0.68196971
98MP0003566_abnormal_cell_adhesion0.68048488
99* MP0005164_abnormal_response_to0.67891299
100MP0000767_abnormal_smooth_muscle0.67544022
101MP0000490_abnormal_crypts_of0.67206725
102MP0001879_abnormal_lymphatic_vessel0.64199972
103MP0003828_pulmonary_edema0.64036279
104MP0002019_abnormal_tumor_incidence0.62158387
105MP0000604_amyloidosis0.61757753
106MP0000343_altered_response_to0.60366181
107MP0008260_abnormal_autophagy0.59818721
108MP0003795_abnormal_bone_structure0.57198355
109MP0002168_other_aberrant_phenotype0.57119316
110MP0002095_abnormal_skin_pigmentation0.56230088
111MP0001663_abnormal_digestive_system0.56167306
112MP0010352_gastrointestinal_tract_polyps0.56005930
113MP0005076_abnormal_cell_differentiation0.55911763
114MP0003943_abnormal_hepatobiliary_system0.55842792
115MP0009643_abnormal_urine_homeostasis0.55411634
116MP0000383_abnormal_hair_follicle0.55163607
117MP0005023_abnormal_wound_healing0.55028178
118MP0008004_abnormal_stomach_pH0.50038926

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.69425714
2Eczematoid dermatitis (HP:0000976)4.59717714
3Recurrent bacterial skin infections (HP:0005406)4.50786597
4Recurrent fungal infections (HP:0002841)4.41128215
5Recurrent viral infections (HP:0004429)4.31688858
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.07986780
7Chronic mucocutaneous candidiasis (HP:0002728)4.02313137
8Recurrent cutaneous fungal infections (HP:0011370)4.02313137
9Elevated erythrocyte sedimentation rate (HP:0003565)3.98873870
10Autoimmune thrombocytopenia (HP:0001973)3.95358386
11Mediastinal lymphadenopathy (HP:0100721)3.91410018
12Abnormality of T cell number (HP:0011839)3.80235391
13Recurrent skin infections (HP:0001581)3.78711082
14Chronic otitis media (HP:0000389)3.77662872
15T lymphocytopenia (HP:0005403)3.68054029
16Myositis (HP:0100614)3.63463696
17Panhypogammaglobulinemia (HP:0003139)3.54741898
18Recurrent gram-negative bacterial infections (HP:0005420)3.50030012
19Vasculitis (HP:0002633)3.45313659
20Colitis (HP:0002583)3.42515522
21* Agammaglobulinemia (HP:0004432)3.40414172
22Meningitis (HP:0001287)3.37439368
23Inflammation of the large intestine (HP:0002037)3.33173700
24Abnormality of the fingertips (HP:0001211)3.27500816
25Recurrent bronchitis (HP:0002837)3.25004486
26Gingival bleeding (HP:0000225)3.22742139
27Periodontitis (HP:0000704)3.17472413
28Gastrointestinal inflammation (HP:0004386)3.10824065
29Abnormality of T cells (HP:0002843)3.09856923
30Stomatitis (HP:0010280)3.07681048
31Retrobulbar optic neuritis (HP:0100654)3.07648179
32Optic neuritis (HP:0100653)3.07648179
33Orchitis (HP:0100796)3.05979906
34Pustule (HP:0200039)2.98434421
35Gingivitis (HP:0000230)2.97015198
36Pulmonary infiltrates (HP:0002113)2.95538894
37Cellulitis (HP:0100658)2.94775319
38IgM deficiency (HP:0002850)2.87149003
39Abnormality of macrophages (HP:0004311)2.86879221
40Gastrointestinal stroma tumor (HP:0100723)2.85615783
41Spontaneous hematomas (HP:0007420)2.83587655
42Lymphopenia (HP:0001888)2.81599829
43Eosinophilia (HP:0001880)2.81061929
44Arterial thrombosis (HP:0004420)2.76426814
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.74996473
46Epistaxis (HP:0000421)2.70904086
47Leukocytosis (HP:0001974)2.69126916
48Abnormality of T cell physiology (HP:0011840)2.68472108
49Thyroiditis (HP:0100646)2.66484591
50Obstructive lung disease (HP:0006536)2.66343462
51Chronic obstructive pulmonary disease (HP:0006510)2.66343462
52Prolonged bleeding time (HP:0003010)2.65036530
53Myocardial infarction (HP:0001658)2.61846741
54Joint hemorrhage (HP:0005261)2.59015919
55Granulocytopenia (HP:0001913)2.56562905
56Abnormality of eosinophils (HP:0001879)2.52696272
57Increased cerebral lipofuscin (HP:0011813)2.52597525
58Osteomyelitis (HP:0002754)2.47642088
59Severe combined immunodeficiency (HP:0004430)2.45967104
60* Chronic diarrhea (HP:0002028)2.41720925
61Hypoplasia of the thymus (HP:0000778)2.40425194
62Hemoptysis (HP:0002105)2.39621451
63Encephalitis (HP:0002383)2.38429470
64Dysostosis multiplex (HP:0000943)2.38385105
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.38203603
66Nasal polyposis (HP:0100582)2.36951305
67Recurrent sinusitis (HP:0011108)2.35410111
68Emphysema (HP:0002097)2.30845350
69Combined immunodeficiency (HP:0005387)2.29964080
70Thrombocytosis (HP:0001894)2.29509112
71IgA deficiency (HP:0002720)2.28642388
72Increased IgE level (HP:0003212)2.27597109
73Vacuolated lymphocytes (HP:0001922)2.26260900
74Abnormality of B cell number (HP:0010975)2.23622055
75B lymphocytopenia (HP:0010976)2.23622055
76Recurrent pneumonia (HP:0006532)2.22547595
77Autoimmune hemolytic anemia (HP:0001890)2.21477500
78Keratoconjunctivitis (HP:0001096)2.20671214
79Hematochezia (HP:0002573)2.20574203
80Keratoconjunctivitis sicca (HP:0001097)2.20299076
81Interstitial pulmonary disease (HP:0006530)2.20008562
82IgG deficiency (HP:0004315)2.19028540
83Joint swelling (HP:0001386)2.17787045
84Gastrointestinal infarctions (HP:0005244)2.14589988
85Abnormality of the prostate (HP:0008775)2.14266577
86Abnormality of the nasal mucosa (HP:0000433)2.12847534
87Abnormality of liposaccharide metabolism (HP:0010968)2.11317705
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.11317705
89Abnormality of glycolipid metabolism (HP:0010969)2.11317705
90Mitral stenosis (HP:0001718)2.10500986
91Abnormality of the pleura (HP:0002103)2.09905879
92Systemic lupus erythematosus (HP:0002725)2.09215112
93Hypochromic anemia (HP:0001931)2.08705012
94Chest pain (HP:0100749)2.07787336
95Premature loss of primary teeth (HP:0006323)2.03012966
96Increased IgM level (HP:0003496)2.02642173
97Pulmonary embolism (HP:0002204)2.01598287
98Recurrent lower respiratory tract infections (HP:0002783)2.01515318
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01206782
100Viral hepatitis (HP:0006562)2.00924301
101Skin ulcer (HP:0200042)1.99801922
102Chronic sinusitis (HP:0011109)1.99399696
103Urticaria (HP:0001025)1.99032997
104Abnormal platelet function (HP:0011869)1.98720271
105Impaired platelet aggregation (HP:0003540)1.98720271
106Verrucae (HP:0200043)1.97216375
107Papilloma (HP:0012740)1.97216375
108Sepsis (HP:0100806)1.95941229
109Hypergammaglobulinemia (HP:0010702)1.95748489
110Restrictive lung disease (HP:0002091)1.95085011
111Loss of speech (HP:0002371)1.92400455
112Abnormality of polysaccharide metabolism (HP:0011012)1.92305204
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92305204
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92305204
115Peritonitis (HP:0002586)1.91556453
116Fatigue (HP:0012378)1.91295469
117Papilledema (HP:0001085)1.90916734
118Spinal cord lesions (HP:0100561)1.90656498
119Syringomyelia (HP:0003396)1.90656498
120Abnormality of the peritoneum (HP:0002585)1.90296633
121Mucopolysacchariduria (HP:0008155)1.89799745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.28218583
2* MAP3K143.21230983
3TYK23.10059326
4TXK3.08978854
5JAK32.96157883
6BLK2.73123413
7IKBKE2.69688278
8IRAK42.56629550
9JAK12.40037271
10TBK12.34790362
11PRPF4B2.32909116
12KIT2.23770125
13FGFR42.06985543
14TRIB31.99413973
15IRAK31.93940556
16* IKBKB1.90324311
17BRD41.88172143
18ERN11.86850941
19STK101.82720640
20ZAP701.82132405
21TAOK31.78726177
22BTK1.71604981
23RIPK41.71497603
24ITK1.69601828
25SIK21.69342729
26CSF1R1.64695369
27TEC1.59985357
28TGFBR21.59128421
29FGFR31.53119713
30SYK1.51802164
31CSK1.50588354
32EPHA31.48715218
33SIK31.46081947
34EPHB11.45817865
35GRK61.41921046
36LCK1.39014405
37SIK11.38363306
38* CHUK1.38287880
39MAP3K101.36494935
40HCK1.31072236
41CDC42BPA1.26817708
42NLK1.26532525
43NEK91.22690282
44PASK1.11488771
45MARK31.11050648
46FLT31.09855175
47CAMKK11.06907658
48JAK21.06834941
49FGR1.06500563
50CDK121.04431823
51PIM11.01586218
52LYN1.01295974
53CAMK1D0.97359755
54PTK60.95461443
55MAP2K30.95413041
56* MAP3K70.94028001
57SMG10.92706392
58MAP3K10.90096697
59LRRK20.88711896
60PDK10.86799631
61MAP3K110.86603749
62CLK10.82977975
63RPS6KA40.80921731
64IRAK10.80710246
65MAP2K60.79564414
66FES0.78837630
67STK40.77688532
68* PRKCQ0.74244176
69INSRR0.73695094
70PDPK10.72121723
71CAMK1G0.70287543
72TAOK10.69408702
73FRK0.68760550
74MST40.65778058
75TRPM70.65734763
76MAP3K60.65342951
77MAP2K20.64997666
78CDK90.63174253
79TNK20.60791977
80EEF2K0.60273196
81MAPK110.59874241
82PKN10.59767840
83RPS6KC10.57728263
84RPS6KL10.57728263
85NUAK10.55441547
86GRK10.55131560
87CAMKK20.54770252
88PRKCH0.54493452
89SGK30.53017855
90CDK60.52877631
91CDK40.52263105
92ABL10.51459418
93MAPKAPK30.50753829
94EIF2AK20.49605436
95TTN0.47730352
96KSR20.45920381
97YES10.45381719
98HIPK20.44141601
99PDGFRB0.44096348
100MELK0.43135190
101RIPK10.42876653
102PKN20.42423311
103IRAK20.42091807
104MAPK70.41581819
105MATK0.40998870
106RET0.40708046
107RPS6KA20.40239700
108PIK3CG0.39788901
109SGK20.39070844
110* PRKAA20.38986101
111WNK10.38477654
112PTK2B0.36306801
113GRK70.35871885
114MAPK120.35624454
115IGF1R0.35465335
116EGFR0.35367673
117PRKCD0.34769025
118MAP3K30.34229474
119MAPK30.33266607
120PRKD20.33218956
121MAPKAPK20.32372704
122FYN0.32302321
123RPS6KA60.32159820
124BMPR20.30927554
125MAPK40.30233859
126MKNK20.29590464
127INSR0.29495728
128MARK20.26623514

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.62585754
2* NF-kappa B signaling pathway_Homo sapiens_hsa040643.13444586
3Leishmaniasis_Homo sapiens_hsa051402.72894587
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.58574004
5Measles_Homo sapiens_hsa051622.49298175
6Staphylococcus aureus infection_Homo sapiens_hsa051502.45482493
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38079000
8* B cell receptor signaling pathway_Homo sapiens_hsa046622.34216374
9* Osteoclast differentiation_Homo sapiens_hsa043802.32365773
10Graft-versus-host disease_Homo sapiens_hsa053322.30488727
11Allograft rejection_Homo sapiens_hsa053302.21612706
12Hematopoietic cell lineage_Homo sapiens_hsa046402.18894945
13* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08897173
14* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93316961
15Caffeine metabolism_Homo sapiens_hsa002321.85606790
16* T cell receptor signaling pathway_Homo sapiens_hsa046601.83757970
17* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77511894
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.71932544
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71424994
20Antigen processing and presentation_Homo sapiens_hsa046121.69989087
21* TNF signaling pathway_Homo sapiens_hsa046681.59258848
22* Herpes simplex infection_Homo sapiens_hsa051681.58339845
23* Toxoplasmosis_Homo sapiens_hsa051451.56199594
24* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55124132
25* Influenza A_Homo sapiens_hsa051641.54614787
26Tuberculosis_Homo sapiens_hsa051521.43999153
27* Chemokine signaling pathway_Homo sapiens_hsa040621.41579164
28Malaria_Homo sapiens_hsa051441.41242957
29Pertussis_Homo sapiens_hsa051331.40934916
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37830828
31Autoimmune thyroid disease_Homo sapiens_hsa053201.32927214
32Legionellosis_Homo sapiens_hsa051341.32583263
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31884872
34Complement and coagulation cascades_Homo sapiens_hsa046101.26220452
35* Apoptosis_Homo sapiens_hsa042101.20080784
36* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17140468
37ABC transporters_Homo sapiens_hsa020101.15767750
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.12508490
39Lysine degradation_Homo sapiens_hsa003101.08279262
40* Hepatitis B_Homo sapiens_hsa051611.06748861
41Asthma_Homo sapiens_hsa053101.06487143
42* Hepatitis C_Homo sapiens_hsa051601.06480338
43* Acute myeloid leukemia_Homo sapiens_hsa052211.03295499
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01186036
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98824689
46Viral myocarditis_Homo sapiens_hsa054160.97556680
47VEGF signaling pathway_Homo sapiens_hsa043700.94361768
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93772015
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.89685165
50Other glycan degradation_Homo sapiens_hsa005110.89189700
51African trypanosomiasis_Homo sapiens_hsa051430.88986083
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86253651
53Platelet activation_Homo sapiens_hsa046110.85860108
54* Chronic myeloid leukemia_Homo sapiens_hsa052200.84137636
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80728236
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80424976
57Type I diabetes mellitus_Homo sapiens_hsa049400.79631381
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78794598
59Dorso-ventral axis formation_Homo sapiens_hsa043200.76803728
60* Small cell lung cancer_Homo sapiens_hsa052220.76603246
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75529508
62Rheumatoid arthritis_Homo sapiens_hsa053230.75498769
63Prolactin signaling pathway_Homo sapiens_hsa049170.74897381
64* Pancreatic cancer_Homo sapiens_hsa052120.74823246
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.72274740
66Salmonella infection_Homo sapiens_hsa051320.69820934
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67580991
68Choline metabolism in cancer_Homo sapiens_hsa052310.67314341
69Lysosome_Homo sapiens_hsa041420.66464708
70* Shigellosis_Homo sapiens_hsa051310.66392554
71Renal cell carcinoma_Homo sapiens_hsa052110.64464529
72GnRH signaling pathway_Homo sapiens_hsa049120.63050594
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.62350514
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.59834775
75* mTOR signaling pathway_Homo sapiens_hsa041500.59208492
76* Insulin resistance_Homo sapiens_hsa049310.57186285
77Tryptophan metabolism_Homo sapiens_hsa003800.54998818
78Notch signaling pathway_Homo sapiens_hsa043300.54559543
79* HTLV-I infection_Homo sapiens_hsa051660.54500835
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53229858
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51147964
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49982261
83Endocytosis_Homo sapiens_hsa041440.48267272
84* Adipocytokine signaling pathway_Homo sapiens_hsa049200.47942308
85Non-homologous end-joining_Homo sapiens_hsa034500.46718670
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46065135
87Non-small cell lung cancer_Homo sapiens_hsa052230.43743816
88* Epstein-Barr virus infection_Homo sapiens_hsa051690.42444523
89Amoebiasis_Homo sapiens_hsa051460.41257682
90Endometrial cancer_Homo sapiens_hsa052130.40642159
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40377960
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39195260
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.38814031
94* Neurotrophin signaling pathway_Homo sapiens_hsa047220.38740402
95Viral carcinogenesis_Homo sapiens_hsa052030.38503097
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38018794
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.36522973
98HIF-1 signaling pathway_Homo sapiens_hsa040660.36004242
99PPAR signaling pathway_Homo sapiens_hsa033200.35646078
100* Prostate cancer_Homo sapiens_hsa052150.35242077
101Inositol phosphate metabolism_Homo sapiens_hsa005620.34763709
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34449962
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34125779
104ErbB signaling pathway_Homo sapiens_hsa040120.33759713
105* FoxO signaling pathway_Homo sapiens_hsa040680.33459234
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33458047
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32914478
108Histidine metabolism_Homo sapiens_hsa003400.32738888
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32714525
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32279171
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31965164
112Bladder cancer_Homo sapiens_hsa052190.31777108
113Estrogen signaling pathway_Homo sapiens_hsa049150.29644178
114Colorectal cancer_Homo sapiens_hsa052100.28942504
115Glioma_Homo sapiens_hsa052140.28791439
116Peroxisome_Homo sapiens_hsa041460.28311435
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.25852846
118* MicroRNAs in cancer_Homo sapiens_hsa052060.24616307
119* MAPK signaling pathway_Homo sapiens_hsa040100.24137834
120Starch and sucrose metabolism_Homo sapiens_hsa005000.24108913
121beta-Alanine metabolism_Homo sapiens_hsa004100.23714556
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22991196
123Phagosome_Homo sapiens_hsa041450.21973677
124Retinol metabolism_Homo sapiens_hsa008300.21971619

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