IKBKE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.55045908
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22239536
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.22239536
4negative regulation of cell killing (GO:0031342)4.98222604
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.98222604
6positive regulation by symbiont of host defense response (GO:0052509)4.88593418
7modulation by symbiont of host defense response (GO:0052031)4.88593418
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.88593418
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.88593418
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.88593418
11modulation by symbiont of host immune response (GO:0052553)4.88593418
12regulation of gamma-delta T cell activation (GO:0046643)4.73197729
13antigen processing and presentation of endogenous antigen (GO:0019883)4.57643325
14response to peptidoglycan (GO:0032494)4.37569358
15regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.35145524
16regulation of gamma-delta T cell differentiation (GO:0045586)4.24862781
17response to muramyl dipeptide (GO:0032495)4.13261752
18positive regulation of humoral immune response (GO:0002922)4.01130542
19leukocyte aggregation (GO:0070486)3.99080211
20negative regulation of interleukin-12 production (GO:0032695)3.86052698
21response to type I interferon (GO:0034340)3.84596207
22neutrophil activation involved in immune response (GO:0002283)3.84509577
23type I interferon signaling pathway (GO:0060337)3.81142711
24cellular response to type I interferon (GO:0071357)3.81142711
25positive regulation of interferon-alpha production (GO:0032727)3.77676672
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.74463314
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68388871
28positive regulation of B cell differentiation (GO:0045579)3.66146098
29regulation of interferon-alpha production (GO:0032647)3.63381552
30positive thymic T cell selection (GO:0045059)3.61539865
31T cell migration (GO:0072678)3.61439341
32negative thymic T cell selection (GO:0045060)3.53763571
33positive regulation of antigen processing and presentation (GO:0002579)3.48567370
34macrophage activation involved in immune response (GO:0002281)3.48498206
35cellular extravasation (GO:0045123)3.48431535
36negative T cell selection (GO:0043383)3.47934767
37positive regulation of cellular amide metabolic process (GO:0034250)3.42141674
38regulation of interferon-beta biosynthetic process (GO:0045357)3.41303746
39regulation of T cell tolerance induction (GO:0002664)3.40405709
40B cell receptor signaling pathway (GO:0050853)3.38521266
41respiratory burst (GO:0045730)3.29542121
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29017324
43response to host immune response (GO:0052572)3.28011614
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.28011614
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27263870
46neutrophil mediated immunity (GO:0002446)3.26669928
47positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24223322
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23444267
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23218890
50B cell mediated immunity (GO:0019724)3.21561302
51Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21460946
52regulation of alpha-beta T cell proliferation (GO:0046640)3.16633605
53interferon-gamma-mediated signaling pathway (GO:0060333)3.16082010
54regulation of B cell receptor signaling pathway (GO:0050855)3.15452749
55negative regulation of T cell mediated immunity (GO:0002710)3.15194239
56regulation of tolerance induction (GO:0002643)3.15070807
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.12869257
58germinal center formation (GO:0002467)3.11281220
59natural killer cell mediated cytotoxicity (GO:0042267)3.10225345
60natural killer cell mediated immunity (GO:0002228)3.10225345
61immunoglobulin mediated immune response (GO:0016064)3.08744653
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.07260031
63negative regulation of leukocyte mediated immunity (GO:0002704)3.06967264
64detection of external biotic stimulus (GO:0098581)3.05272362
65myeloid dendritic cell activation (GO:0001773)3.04706903
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03787802
67response to host (GO:0075136)3.03715151
68response to host defenses (GO:0052200)3.03715151
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.03715151
70modulation by symbiont of host cellular process (GO:0044068)3.03308157
71myeloid cell activation involved in immune response (GO:0002275)3.02366667
72mannose metabolic process (GO:0006013)3.01742851
73* NIK/NF-kappaB signaling (GO:0038061)3.01358727
74positive regulation of interferon-beta production (GO:0032728)3.00654353
75leukocyte cell-cell adhesion (GO:0007159)3.00541222
76regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99915036
77regulation of antigen processing and presentation (GO:0002577)2.98213503
78regulation of B cell differentiation (GO:0045577)2.97934848
79negative regulation of erythrocyte differentiation (GO:0045647)2.97378965
80regulation of mast cell degranulation (GO:0043304)2.97240255
81response to interferon-alpha (GO:0035455)2.96562805
82thymic T cell selection (GO:0045061)2.95530485
83neutrophil activation (GO:0042119)2.92429589
84myeloid dendritic cell differentiation (GO:0043011)2.91192678
85granulocyte activation (GO:0036230)2.90400032
86T cell selection (GO:0045058)2.89339659
87positive regulation of immunoglobulin mediated immune response (GO:0002891)2.89199649
88positive regulation of B cell mediated immunity (GO:0002714)2.89199649
89cellular response to virus (GO:0098586)2.89113132
90detection of other organism (GO:0098543)2.88866330
91positive T cell selection (GO:0043368)2.88828414
92lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87517807
93tolerance induction (GO:0002507)2.86187844
94negative regulation of interleukin-1 beta production (GO:0032691)2.86178119
95detection of bacterium (GO:0016045)2.84703178
96positive regulation of interleukin-1 beta secretion (GO:0050718)2.84090296
97regulation of T cell mediated cytotoxicity (GO:0001914)2.83862710
98regulation of T-helper 1 cell differentiation (GO:0045625)2.83573831
99negative regulation of growth of symbiont in host (GO:0044130)2.83260146
100negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.83260146
101modulation of growth of symbiont involved in interaction with host (GO:0044144)2.83260146
102regulation of growth of symbiont in host (GO:0044126)2.83260146
103defense response to protozoan (GO:0042832)2.82411789
104negative regulation of myeloid cell apoptotic process (GO:0033033)2.82007167
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81937387
106regulation of natural killer cell mediated immunity (GO:0002715)2.81937387
107detection of molecule of bacterial origin (GO:0032490)2.81904673
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.81769573
109positive regulation of tolerance induction (GO:0002645)2.80646802
110negative regulation of innate immune response (GO:0045824)2.80187082
111microglial cell activation (GO:0001774)2.79625137
112positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.79404575
113regulation of interleukin-1 beta secretion (GO:0050706)2.78969580
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75549888
115macrophage activation (GO:0042116)2.75247335
116response to interleukin-15 (GO:0070672)2.75232574
117antigen processing and presentation via MHC class Ib (GO:0002475)2.74815226
118detection of biotic stimulus (GO:0009595)2.74649436
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74622840
120response to protozoan (GO:0001562)2.74134289
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73557587
122regulation of lymphocyte migration (GO:2000401)2.73528149
123mature B cell differentiation (GO:0002335)2.72875878
124regulation of leukocyte degranulation (GO:0043300)2.70581972
125cytokine secretion (GO:0050663)2.70087426
126regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68954082
127negative regulation of cytokine production involved in immune response (GO:0002719)2.68496932
128leukocyte mediated cytotoxicity (GO:0001909)2.68077365
129negative regulation of phagocytosis (GO:0050765)2.67771643
130hydrogen peroxide biosynthetic process (GO:0050665)2.67190663
131regulation of interleukin-12 production (GO:0032655)2.67181484
132regulation of mast cell activation involved in immune response (GO:0033006)2.65521533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.93085233
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.92642367
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.36268626
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.30741449
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.03424709
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00062485
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56396558
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.41635963
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.41097102
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40867911
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17663601
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95494091
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.93573038
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64021869
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.61153910
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59621213
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57490726
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50329537
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47107342
20SCL_19346495_ChIP-Seq_HPC-7_Human2.38418230
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33386223
22RUNX_20019798_ChIP-Seq_JUKART_Human2.33095611
23VDR_21846776_ChIP-Seq_THP-1_Human2.21863981
24MYB_26560356_Chip-Seq_TH2_Human2.18711020
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13631924
26* MAF_26560356_Chip-Seq_TH1_Human2.12153185
27* SPI1_23547873_ChIP-Seq_NB4_Human2.03896594
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02053015
29* VDR_24763502_ChIP-Seq_THP-1_Human2.00418460
30* MYB_26560356_Chip-Seq_TH1_Human1.99565624
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97424822
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95646272
33MYC_22102868_ChIP-Seq_BL_Human1.87482671
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85883698
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.85057263
36* UTX_26944678_Chip-Seq_JUKART_Human1.76438183
37SPI1_23127762_ChIP-Seq_K562_Human1.75547926
38* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71132104
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69174496
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68083184
41* RXR_22158963_ChIP-Seq_LIVER_Mouse1.65865897
42* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64501984
43* PU_27001747_Chip-Seq_BMDM_Mouse1.64492835
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62567833
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.61782843
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59580485
47* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59274582
48TCF7_22412390_ChIP-Seq_EML_Mouse1.58262631
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52354714
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51476658
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50118474
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48261377
53GATA1_22025678_ChIP-Seq_K562_Human1.47566712
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44734616
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44708083
56MAF_26560356_Chip-Seq_TH2_Human1.42130060
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41740215
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41602863
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.41047299
60GATA3_27048872_Chip-Seq_THYMUS_Human1.40679387
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36169923
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34983478
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32166722
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31085077
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26979717
66* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26884713
67VDR_24787735_ChIP-Seq_THP-1_Human1.25770748
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23305041
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.22661875
70BCL6_27268052_Chip-Seq_Bcells_Human1.21547230
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21453696
72* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20718393
73GATA3_26560356_Chip-Seq_TH2_Human1.19984036
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19097042
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18452059
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17872788
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16336988
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15119249
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.14109956
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13062569
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12609557
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.12063584
83BCOR_27268052_Chip-Seq_Bcells_Human1.11745810
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08493661
85* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07681551
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06915713
87* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05793945
88KDM2B_26808549_Chip-Seq_DND41_Human1.05163331
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04989034
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04942250
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03562440
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99035597
93TFEB_21752829_ChIP-Seq_HELA_Human0.98688533
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97736539
95CIITA_25753668_ChIP-Seq_RAJI_Human0.97660460
96E2F7_22180533_ChIP-Seq_HELA_Human0.96986640
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93277556
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92350501
99* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91436101
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.91412860
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90955391
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.90338297
103* RACK7_27058665_Chip-Seq_MCF-7_Human0.86908372
104CTCF_26484167_Chip-Seq_Bcells_Mouse0.85574148
105* SA1_27219007_Chip-Seq_ERYTHROID_Human0.85482872
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84478154
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84379783
108SPI1_20517297_ChIP-Seq_HL60_Human0.84315771
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84171131
110RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84101839
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.83494083
112* GATA2_19941826_ChIP-Seq_K562_Human0.82744915
113GATA1_19941826_ChIP-Seq_K562_Human0.81882608
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81225979
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78804301
116* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77570465
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77471865
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75495560
119NCOR1_26117541_ChIP-Seq_K562_Human0.75454143
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.74569102
121* LXR_22292898_ChIP-Seq_THP-1_Human0.73003114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.73295891
2MP0003436_decreased_susceptibility_to3.40183623
3MP0000685_abnormal_immune_system3.32502875
4MP0009785_altered_susceptibility_to3.29476523
5MP0003303_peritoneal_inflammation2.88207448
6MP0005387_immune_system_phenotype2.86405768
7MP0001790_abnormal_immune_system2.86405768
8MP0002419_abnormal_innate_immunity2.76846563
9* MP0005025_abnormal_response_to2.76306286
10MP0005000_abnormal_immune_tolerance2.75224071
11MP0001800_abnormal_humoral_immune2.70108833
12MP0000569_abnormal_digit_pigmentation2.63527602
13MP0005671_abnormal_response_to2.60346019
14MP0003763_abnormal_thymus_physiology2.54429794
15MP0002723_abnormal_immune_serum2.50150787
16MP0002452_abnormal_antigen_presenting2.48566620
17MP0002148_abnormal_hypersensitivity_rea2.45122663
18MP0005464_abnormal_platelet_physiology2.40446421
19MP0003724_increased_susceptibility_to2.37966083
20MP0004947_skin_inflammation2.32027286
21MP0001819_abnormal_immune_cell2.29301038
22MP0002420_abnormal_adaptive_immunity2.28546279
23MP0006082_CNS_inflammation2.19999290
24MP0005058_abnormal_lysosome_morphology2.11755924
25MP0009278_abnormal_bone_marrow2.07178210
26MP0002166_altered_tumor_susceptibility2.05042937
27MP0010155_abnormal_intestine_physiology1.98304285
28MP0003172_abnormal_lysosome_physiology1.97223683
29MP0004510_myositis1.95438947
30MP0002398_abnormal_bone_marrow1.89940557
31* MP0002405_respiratory_system_inflammati1.88990329
32MP0001845_abnormal_inflammatory_respons1.84625761
33MP0000716_abnormal_immune_system1.81917178
34MP0003300_gastrointestinal_ulcer1.79880539
35MP0002006_tumorigenesis1.72528911
36MP0009840_abnormal_foam_cell1.70491439
37MP0001873_stomach_inflammation1.70077630
38MP0001533_abnormal_skeleton_physiology1.67578164
39MP0009333_abnormal_splenocyte_physiolog1.65497005
40MP0001545_abnormal_hematopoietic_system1.64497939
41MP0005397_hematopoietic_system_phenotyp1.64497939
42MP0000689_abnormal_spleen_morphology1.62617458
43MP0005174_abnormal_tail_pigmentation1.62115830
44MP0008469_abnormal_protein_level1.61104463
45MP0001853_heart_inflammation1.60393506
46MP0003183_abnormal_peptide_metabolism1.56959878
47MP0002722_abnormal_immune_system1.53659699
48MP0002396_abnormal_hematopoietic_system1.53277221
49MP0002429_abnormal_blood_cell1.48497640
50MP0009764_decreased_sensitivity_to1.48202326
51MP0003806_abnormal_nucleotide_metabolis1.45867357
52MP0005360_urolithiasis1.33635747
53MP0003448_altered_tumor_morphology1.30088215
54MP0000858_altered_metastatic_potential1.29384554
55MP0000703_abnormal_thymus_morphology1.25304786
56MP0005083_abnormal_biliary_tract1.23880514
57MP0003191_abnormal_cellular_cholesterol1.23600701
58MP0003866_abnormal_defecation1.22554788
59MP0009763_increased_sensitivity_to1.21189696
60MP0000604_amyloidosis1.16488826
61MP0002254_reproductive_system_inflammat1.16293254
62MP0004381_abnormal_hair_follicle1.15013924
63MP0002998_abnormal_bone_remodeling1.14046757
64MP0004808_abnormal_hematopoietic_stem1.14003730
65MP0002139_abnormal_hepatobiliary_system1.10309767
66MP0000465_gastrointestinal_hemorrhage1.08133840
67MP0002933_joint_inflammation1.07192131
68MP0001851_eye_inflammation1.03998582
69MP0005310_abnormal_salivary_gland1.02817097
70MP0000371_diluted_coat_color1.00022457
71MP0000609_abnormal_liver_physiology0.99308767
72MP0010352_gastrointestinal_tract_polyps0.98229067
73MP0000343_altered_response_to0.98092894
74MP0008004_abnormal_stomach_pH0.97991994
75MP0002132_abnormal_respiratory_system0.97430788
76MP0008260_abnormal_autophagy0.96556015
77MP0003075_altered_response_to0.94467456
78MP0002138_abnormal_hepatobiliary_system0.93370609
79MP0004883_abnormal_blood_vessel0.93109098
80MP0005365_abnormal_bile_salt0.92091296
81MP0005451_abnormal_body_composition0.91772070
82MP0000015_abnormal_ear_pigmentation0.89094488
83MP0003453_abnormal_keratinocyte_physiol0.88582856
84MP0003656_abnormal_erythrocyte_physiolo0.88404535
85MP0005164_abnormal_response_to0.88157395
86MP0005075_abnormal_melanosome_morpholog0.87961457
87MP0000490_abnormal_crypts_of0.87077474
88MP0005076_abnormal_cell_differentiation0.86123522
89MP0005023_abnormal_wound_healing0.85366569
90MP0010307_abnormal_tumor_latency0.82893870
91MP0003795_abnormal_bone_structure0.82672761
92MP0009765_abnormal_xenobiotic_induced0.82034412
93MP0005166_decreased_susceptibility_to0.74332984
94MP0003566_abnormal_cell_adhesion0.73081125
95MP0003091_abnormal_cell_migration0.71517282
96MP0002877_abnormal_melanocyte_morpholog0.71035993
97MP0005390_skeleton_phenotype0.69701856
98MP0002277_abnormal_respiratory_mucosa0.68012896
99MP0000249_abnormal_blood_vessel0.67718857
100MP0003828_pulmonary_edema0.64999267
101MP0000598_abnormal_liver_morphology0.64924757
102MP0006054_spinal_hemorrhage0.64548527
103MP0003690_abnormal_glial_cell0.64264404
104MP0002136_abnormal_kidney_physiology0.63936194
105MP0005085_abnormal_gallbladder_physiolo0.63885997
106MP0002019_abnormal_tumor_incidence0.62120483
107MP0010329_abnormal_lipoprotein_level0.61049301
108MP0001663_abnormal_digestive_system0.61018429
109MP0003279_aneurysm0.60908890
110MP0001191_abnormal_skin_condition0.60751995
111MP0003329_amyloid_beta_deposits0.59177287
112MP0008874_decreased_physiological_sensi0.57247191
113MP0001542_abnormal_bone_strength0.53687716
114MP0005165_increased_susceptibility_to0.52395147

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.57538892
2Elevated erythrocyte sedimentation rate (HP:0003565)5.55381451
3Eczematoid dermatitis (HP:0000976)5.46126532
4Recurrent bacterial skin infections (HP:0005406)5.20712878
5Stomatitis (HP:0010280)5.09979904
6Myositis (HP:0100614)4.66116335
7Autoimmune thrombocytopenia (HP:0001973)4.63478251
8Recurrent gram-negative bacterial infections (HP:0005420)4.59668294
9Mediastinal lymphadenopathy (HP:0100721)4.20523975
10Recurrent fungal infections (HP:0002841)4.11670659
11Orchitis (HP:0100796)4.10938394
12Pustule (HP:0200039)3.99117730
13Optic neuritis (HP:0100653)3.98894095
14Retrobulbar optic neuritis (HP:0100654)3.98894095
15Abnormality of macrophages (HP:0004311)3.96741520
16Recurrent viral infections (HP:0004429)3.91786328
17Abnormality of liposaccharide metabolism (HP:0010968)3.74156031
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.74156031
19Abnormality of glycolipid metabolism (HP:0010969)3.74156031
20Recurrent skin infections (HP:0001581)3.71495164
21Periodontitis (HP:0000704)3.58769561
22Gingivitis (HP:0000230)3.52960405
23Vasculitis (HP:0002633)3.46795655
24Abnormality of T cell number (HP:0011839)3.33883353
25Chronic otitis media (HP:0000389)3.32469506
26Agammaglobulinemia (HP:0004432)3.31950334
27Gingival bleeding (HP:0000225)3.28366071
28T lymphocytopenia (HP:0005403)3.27427449
29Chronic mucocutaneous candidiasis (HP:0002728)3.23767155
30Recurrent cutaneous fungal infections (HP:0011370)3.23767155
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.22682928
32Pulmonary infiltrates (HP:0002113)3.19283506
33Leukocytosis (HP:0001974)3.08721657
34Dysostosis multiplex (HP:0000943)3.05876289
35Chronic obstructive pulmonary disease (HP:0006510)3.05814884
36Obstructive lung disease (HP:0006536)3.05814884
37Vacuolated lymphocytes (HP:0001922)3.05054786
38Meningitis (HP:0001287)2.92821729
39Arterial thrombosis (HP:0004420)2.89092227
40Joint hemorrhage (HP:0005261)2.82703770
41Loss of speech (HP:0002371)2.80041891
42Abnormality of T cells (HP:0002843)2.79707486
43Nasal polyposis (HP:0100582)2.75542126
44Gastrointestinal stroma tumor (HP:0100723)2.75059676
45Epistaxis (HP:0000421)2.74543270
46Petechiae (HP:0000967)2.73224913
47Increased IgE level (HP:0003212)2.70250987
48Hemoptysis (HP:0002105)2.68721635
49Amyloidosis (HP:0011034)2.68163516
50Keratoconjunctivitis sicca (HP:0001097)2.61658937
51Joint swelling (HP:0001386)2.59857347
52Eosinophilia (HP:0001880)2.59564237
53Thrombocytosis (HP:0001894)2.57506448
54Urticaria (HP:0001025)2.55346344
55Increased cerebral lipofuscin (HP:0011813)2.53404737
56Gastrointestinal infarctions (HP:0005244)2.53141231
57Recurrent bronchitis (HP:0002837)2.52678231
58Autoimmune hemolytic anemia (HP:0001890)2.51353227
59Keratoconjunctivitis (HP:0001096)2.48752339
60Myocardial infarction (HP:0001658)2.47272398
61Increased IgM level (HP:0003496)2.45584390
62Abnormality of T cell physiology (HP:0011840)2.45033219
63Hypergammaglobulinemia (HP:0010702)2.44856222
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.40308434
65Increased serum ferritin (HP:0003281)2.39340528
66Hepatosplenomegaly (HP:0001433)2.39217060
67Spontaneous hematomas (HP:0007420)2.37715185
68Systemic lupus erythematosus (HP:0002725)2.37026982
69Abnormality of the fingertips (HP:0001211)2.36648120
70Abnormality of the nasal mucosa (HP:0000433)2.34656036
71Abnormality of eosinophils (HP:0001879)2.31457718
72Thick nail (HP:0001805)2.31272388
73Inflammation of the large intestine (HP:0002037)2.30987184
74Cellulitis (HP:0100658)2.30930107
75Prolonged bleeding time (HP:0003010)2.30519363
76Interstitial pulmonary disease (HP:0006530)2.29329109
77Premature loss of primary teeth (HP:0006323)2.27597086
78Prostate neoplasm (HP:0100787)2.26551955
79Purpura (HP:0000979)2.25823546
80Chest pain (HP:0100749)2.25419048
81Granulocytopenia (HP:0001913)2.24071205
82Abnormality of polysaccharide metabolism (HP:0011012)2.23094045
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23094045
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23094045
85Sepsis (HP:0100806)2.21221734
86Osteomyelitis (HP:0002754)2.20512534
87Gastrointestinal inflammation (HP:0004386)2.18205373
88Colitis (HP:0002583)2.17584397
89Abnormality of the prostate (HP:0008775)2.16964383
90Combined immunodeficiency (HP:0005387)2.14919251
91Panhypogammaglobulinemia (HP:0003139)2.14676018
92Encephalitis (HP:0002383)2.12653923
93Verrucae (HP:0200043)2.12154416
94Papilloma (HP:0012740)2.12154416
95Frequent falls (HP:0002359)2.10911862
96Mucopolysacchariduria (HP:0008155)2.10398758
97Urinary glycosaminoglycan excretion (HP:0003541)2.10398758
98Menorrhagia (HP:0000132)2.10285933
99Progressive neurologic deterioration (HP:0002344)2.09080613
100Severe combined immunodeficiency (HP:0004430)2.06690264
101Pulmonary embolism (HP:0002204)2.06052492
102IgG deficiency (HP:0004315)2.05585452
103Hematochezia (HP:0002573)2.04695224
104Gangrene (HP:0100758)2.04422712
105Abnormality of iron homeostasis (HP:0011031)2.03159580
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.01825595
107Tetraparesis (HP:0002273)2.01154310
108IgM deficiency (HP:0002850)2.00372003
109Lymphopenia (HP:0001888)2.00026118
110Skin ulcer (HP:0200042)1.99108990
111Cheilitis (HP:0100825)1.97567405
112Thrombophlebitis (HP:0004418)1.97559418
113Restrictive lung disease (HP:0002091)1.97297846
114Anorexia (HP:0002039)1.96790844
115Recurrent pneumonia (HP:0006532)1.96589059
116Basal ganglia calcification (HP:0002135)1.96380475
117Abnormality of the pleura (HP:0002103)1.95163861
118Recurrent lower respiratory tract infections (HP:0002783)1.95070405
119Abnormality of B cell number (HP:0010975)1.94066134
120Chronic diarrhea (HP:0002028)1.93850235
121Skin rash (HP:0000988)1.91852122
122Thyroiditis (HP:0100646)1.91520023
123Glomerulonephritis (HP:0000099)1.91391097
124Abnormality of the common coagulation pathway (HP:0010990)1.90209364
125Polyneuropathy (HP:0001271)1.87979874
126Arthralgia (HP:0002829)1.85349286
127Splenomegaly (HP:0001744)1.85290779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.11733968
2MAP4K14.10410272
3TYK23.87018584
4TXK3.30572953
5IRAK33.08200238
6JAK33.06247296
7TBK12.95262163
8IRAK42.86725272
9MAP3K132.73520844
10PRPF4B2.59017888
11RIPK42.57560015
12BLK2.46237925
13* IKBKE2.42609233
14JAK12.38688141
15TESK22.28712753
16ZAP702.19137198
17ERN12.17562221
18KIT2.14793061
19IKBKB2.10616905
20FGFR42.03685017
21TAOK31.89131046
22MAP3K111.73129586
23KDR1.50266782
24CSK1.50042351
25LCK1.48593849
26ITK1.46157672
27CHUK1.45273269
28HCK1.44340370
29TAOK21.43615137
30STK101.42360842
31SYK1.42288685
32BTK1.40500352
33GRK71.37079553
34SIK21.36997407
35RPS6KA41.36389401
36SCYL21.28381610
37TEC1.27682359
38PTK61.25469121
39TNK21.23152779
40EEF2K1.22792239
41JAK21.21657032
42MAP3K101.20759014
43MARK31.20095201
44CSF1R1.16835141
45FGFR31.15789578
46TAOK11.14257723
47TESK11.13874607
48EPHB11.13153139
49FES1.08432007
50SMG11.07848895
51NME21.06655873
52PIM11.05345810
53GRK61.04020156
54MAP3K11.03052474
55MATK1.00711865
56TTN0.99675645
57SIK10.98265535
58CDK120.97090061
59LYN0.96980073
60NLK0.91284220
61MAP2K30.88213556
62CDC42BPA0.87218681
63CAMKK20.86181121
64SIK30.82755776
65TRPM70.76760349
66BMPR20.76266293
67PIM20.72732539
68NEK90.71641882
69MAP3K80.65936368
70MST1R0.65141145
71PRKCQ0.63780100
72FLT30.62185918
73PRKD20.61754014
74PKN20.61695599
75STK40.59791824
76LRRK20.57740908
77TRIB30.57719029
78TGFBR20.57646385
79CDK60.55659844
80MAP3K70.55078653
81EGFR0.54508112
82DAPK20.54408952
83RPS6KA60.54038274
84FGR0.53679115
85MOS0.52010093
86PRKG20.51625376
87MAPK110.51015739
88IRAK20.48556281
89MAPK70.48035434
90CDK40.47655396
91ABL10.47557245
92RPS6KL10.45137068
93RPS6KC10.45137068
94PDPK10.45009316
95MARK20.43885993
96ARAF0.43830109
97EIF2AK20.43254300
98YES10.43049329
99PDGFRB0.42408621
100BMX0.42396895
101MST40.40409750
102CLK10.40107134
103PDK10.40084699
104RPS6KA20.40059115
105EPHA30.38581494
106NUAK10.37982156
107MAPK40.36538257
108PAK40.34960377
109PRKCH0.34613799
110HIPK20.32569027
111PRKCD0.32425953
112PTK20.32250810
113FYN0.31803595
114MAPKAPK20.31646241
115MAP2K60.30846533
116CAMK1D0.28725634
117BRD40.27662029
118MAP3K30.27422521
119MAP3K50.25442013
120SGK30.24489453
121RIPK10.24083762
122DAPK30.22651298
123IGF1R0.21748627
124MAPK30.21710988
125MAPK120.21496489
126IRAK10.21124796

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.02700093
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.02626652
3Staphylococcus aureus infection_Homo sapiens_hsa051502.91873426
4Primary immunodeficiency_Homo sapiens_hsa053402.65340404
5Osteoclast differentiation_Homo sapiens_hsa043802.49161493
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.47168291
7* Measles_Homo sapiens_hsa051622.46663390
8* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.29547438
9* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26767340
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20733121
11Allograft rejection_Homo sapiens_hsa053302.19479574
12Graft-versus-host disease_Homo sapiens_hsa053322.04684964
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.02070922
14TNF signaling pathway_Homo sapiens_hsa046681.95730698
15* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92030454
16* Influenza A_Homo sapiens_hsa051641.91642973
17B cell receptor signaling pathway_Homo sapiens_hsa046621.91565970
18Malaria_Homo sapiens_hsa051441.88938184
19Pertussis_Homo sapiens_hsa051331.86558894
20Asthma_Homo sapiens_hsa053101.85418707
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83156583
22T cell receptor signaling pathway_Homo sapiens_hsa046601.83140526
23Caffeine metabolism_Homo sapiens_hsa002321.82579333
24Legionellosis_Homo sapiens_hsa051341.79218568
25Tuberculosis_Homo sapiens_hsa051521.72718975
26Hematopoietic cell lineage_Homo sapiens_hsa046401.67433961
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.62246112
28Toxoplasmosis_Homo sapiens_hsa051451.60555454
29* Herpes simplex infection_Homo sapiens_hsa051681.57677045
30Apoptosis_Homo sapiens_hsa042101.40850644
31Antigen processing and presentation_Homo sapiens_hsa046121.40632176
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40519671
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37197009
34Acute myeloid leukemia_Homo sapiens_hsa052211.36613931
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33503771
36* Hepatitis C_Homo sapiens_hsa051601.32684649
37Complement and coagulation cascades_Homo sapiens_hsa046101.27699868
38* Hepatitis B_Homo sapiens_hsa051611.23020662
39Chemokine signaling pathway_Homo sapiens_hsa040621.20541838
40Rheumatoid arthritis_Homo sapiens_hsa053231.15762763
41Shigellosis_Homo sapiens_hsa051311.14908072
42African trypanosomiasis_Homo sapiens_hsa051431.13771438
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.10661540
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10391486
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.05092775
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04268776
47ABC transporters_Homo sapiens_hsa020101.02337435
48Lysosome_Homo sapiens_hsa041421.01538515
49Other glycan degradation_Homo sapiens_hsa005110.97930085
50Chronic myeloid leukemia_Homo sapiens_hsa052200.94539555
51Viral myocarditis_Homo sapiens_hsa054160.94301815
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.92528894
53Type I diabetes mellitus_Homo sapiens_hsa049400.90934601
54Autoimmune thyroid disease_Homo sapiens_hsa053200.90475458
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87285469
56Salmonella infection_Homo sapiens_hsa051320.86278279
57Prolactin signaling pathway_Homo sapiens_hsa049170.85956525
58Pancreatic cancer_Homo sapiens_hsa052120.77066472
59Phagosome_Homo sapiens_hsa041450.76700612
60Platelet activation_Homo sapiens_hsa046110.76689685
61Small cell lung cancer_Homo sapiens_hsa052220.76068624
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.72644871
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70515385
64Insulin resistance_Homo sapiens_hsa049310.68396837
65Amoebiasis_Homo sapiens_hsa051460.64515747
66Type II diabetes mellitus_Homo sapiens_hsa049300.63412026
67Lysine degradation_Homo sapiens_hsa003100.61127481
68Endocytosis_Homo sapiens_hsa041440.58545677
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.57384308
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57182482
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55744128
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55439854
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54560386
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54236192
75Epstein-Barr virus infection_Homo sapiens_hsa051690.54235200
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53971772
77Arginine biosynthesis_Homo sapiens_hsa002200.53321626
78Bladder cancer_Homo sapiens_hsa052190.53055211
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51454412
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50774764
81Galactose metabolism_Homo sapiens_hsa000520.46978981
82One carbon pool by folate_Homo sapiens_hsa006700.45538141
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45121079
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44358483
85HTLV-I infection_Homo sapiens_hsa051660.42912863
86Systemic lupus erythematosus_Homo sapiens_hsa053220.42813094
87Viral carcinogenesis_Homo sapiens_hsa052030.41094046
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40108706
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.36704291
90Prion diseases_Homo sapiens_hsa050200.36586465
91Renal cell carcinoma_Homo sapiens_hsa052110.34991219
92Notch signaling pathway_Homo sapiens_hsa043300.33584151
93VEGF signaling pathway_Homo sapiens_hsa043700.32842932
94Histidine metabolism_Homo sapiens_hsa003400.32219092
95Fructose and mannose metabolism_Homo sapiens_hsa000510.32116848
96Selenocompound metabolism_Homo sapiens_hsa004500.31606151
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30269800
98Tryptophan metabolism_Homo sapiens_hsa003800.30177470
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29170697
100HIF-1 signaling pathway_Homo sapiens_hsa040660.28550868
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27856988
102Non-small cell lung cancer_Homo sapiens_hsa052230.27517588
103Starch and sucrose metabolism_Homo sapiens_hsa005000.27224960
104Pentose phosphate pathway_Homo sapiens_hsa000300.27083926
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.26989358
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26838491
107mTOR signaling pathway_Homo sapiens_hsa041500.26439696
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26078445
109p53 signaling pathway_Homo sapiens_hsa041150.24154200
110MAPK signaling pathway_Homo sapiens_hsa040100.22894418
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22394658
112Prostate cancer_Homo sapiens_hsa052150.21126205
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.20758793
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19906617
115Colorectal cancer_Homo sapiens_hsa052100.17365602
116Collecting duct acid secretion_Homo sapiens_hsa049660.13959951
117Inositol phosphate metabolism_Homo sapiens_hsa005620.12772817
118FoxO signaling pathway_Homo sapiens_hsa040680.12362428
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.12279416

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