IKBKG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.23723570
2L-phenylalanine catabolic process (GO:0006559)6.23723570
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.80586862
4L-phenylalanine metabolic process (GO:0006558)5.80586862
5aromatic amino acid family catabolic process (GO:0009074)5.63051317
6glyoxylate metabolic process (GO:0046487)5.52371391
7bile acid biosynthetic process (GO:0006699)5.29946056
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.23357436
9indole-containing compound catabolic process (GO:0042436)5.12742507
10indolalkylamine catabolic process (GO:0046218)5.12742507
11tryptophan catabolic process (GO:0006569)5.12742507
12protein carboxylation (GO:0018214)4.94918975
13peptidyl-glutamic acid carboxylation (GO:0017187)4.94918975
14complement activation, alternative pathway (GO:0006957)4.91445934
15tryptophan metabolic process (GO:0006568)4.85113186
16kynurenine metabolic process (GO:0070189)4.82316549
17neutrophil activation involved in immune response (GO:0002283)4.78792386
18negative regulation of fibrinolysis (GO:0051918)4.74432010
19regulation of protein activation cascade (GO:2000257)4.72361559
20regulation of fibrinolysis (GO:0051917)4.61509395
21alpha-linolenic acid metabolic process (GO:0036109)4.59975777
22urea metabolic process (GO:0019627)4.58879486
23urea cycle (GO:0000050)4.58879486
24nitrogen cycle metabolic process (GO:0071941)4.58743045
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.56688633
26negative regulation of cell killing (GO:0031342)4.56688633
27cysteine metabolic process (GO:0006534)4.53458178
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.45824019
29modulation by symbiont of host immune response (GO:0052553)4.45824019
30positive regulation by symbiont of host defense response (GO:0052509)4.45824019
31modulation by symbiont of host defense response (GO:0052031)4.45824019
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.45824019
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.45824019
34response to peptidoglycan (GO:0032494)4.44364174
35regulation of complement activation (GO:0030449)4.42961886
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38525382
37positive regulation of gamma-delta T cell activation (GO:0046645)4.36847452
38high-density lipoprotein particle remodeling (GO:0034375)4.34877454
39bile acid metabolic process (GO:0008206)4.29763864
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26560294
41plasma lipoprotein particle clearance (GO:0034381)4.24112743
42aldehyde catabolic process (GO:0046185)4.22554692
43tyrosine metabolic process (GO:0006570)4.19321901
44regulation of triglyceride catabolic process (GO:0010896)4.15963498
45aromatic amino acid family metabolic process (GO:0009072)4.13890215
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13512505
47antigen processing and presentation of endogenous antigen (GO:0019883)4.12312802
48sulfur amino acid catabolic process (GO:0000098)4.08634071
49homocysteine metabolic process (GO:0050667)4.06683338
50phospholipid efflux (GO:0033700)3.98331740
51amine catabolic process (GO:0009310)3.91097480
52cellular biogenic amine catabolic process (GO:0042402)3.91097480
53cholesterol efflux (GO:0033344)3.89279524
54macrophage activation involved in immune response (GO:0002281)3.88292930
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87775769
56plasma lipoprotein particle remodeling (GO:0034369)3.86880738
57protein-lipid complex remodeling (GO:0034368)3.86880738
58macromolecular complex remodeling (GO:0034367)3.86880738
59leukocyte aggregation (GO:0070486)3.85862984
60opsonization (GO:0008228)3.85632506
61triglyceride homeostasis (GO:0070328)3.84761517
62acylglycerol homeostasis (GO:0055090)3.84761517
63serine family amino acid catabolic process (GO:0009071)3.84142846
64reverse cholesterol transport (GO:0043691)3.79735077
65detection of other organism (GO:0098543)3.78977654
66negative regulation of interleukin-12 production (GO:0032695)3.77087806
67negative regulation of erythrocyte differentiation (GO:0045647)3.76997816
68regulation of cholesterol esterification (GO:0010872)3.75340397
69detection of bacterium (GO:0016045)3.73635354
70amino-acid betaine metabolic process (GO:0006577)3.71792485
71fibrinolysis (GO:0042730)3.68687877
72phospholipid homeostasis (GO:0055091)3.68195559
73indolalkylamine metabolic process (GO:0006586)3.67138454
74cellular glucuronidation (GO:0052695)3.62178245
75alpha-amino acid catabolic process (GO:1901606)3.60960288
76coenzyme catabolic process (GO:0009109)3.58007608
77cofactor catabolic process (GO:0051187)3.56666535
78very long-chain fatty acid metabolic process (GO:0000038)3.53765282
79serine family amino acid biosynthetic process (GO:0009070)3.51891607
80acetyl-CoA metabolic process (GO:0006084)3.48496941
81regulation of mast cell degranulation (GO:0043304)3.44954369
82negative regulation of lipase activity (GO:0060192)3.44684114
83very-low-density lipoprotein particle assembly (GO:0034379)3.44460117
84plasma lipoprotein particle assembly (GO:0034377)3.44331072
85negative regulation of cholesterol transport (GO:0032375)3.43491174
86negative regulation of sterol transport (GO:0032372)3.43491174
87serine family amino acid metabolic process (GO:0009069)3.43283168
88immunoglobulin mediated immune response (GO:0016064)3.42492135
89cellular response to ethanol (GO:0071361)3.42422065
90lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39590559
91imidazole-containing compound metabolic process (GO:0052803)3.38795455
92bile acid and bile salt transport (GO:0015721)3.38286854
93benzene-containing compound metabolic process (GO:0042537)3.37302869
94urate metabolic process (GO:0046415)3.37185813
95regulation of interferon-beta biosynthetic process (GO:0045357)3.35838013
96granulocyte activation (GO:0036230)3.33482960
97neutrophil activation (GO:0042119)3.32341651
98NIK/NF-kappaB signaling (GO:0038061)3.31434464
99cholesterol homeostasis (GO:0042632)3.31239182
100uronic acid metabolic process (GO:0006063)3.31163399
101glucuronate metabolic process (GO:0019585)3.31163399
102cytolysis (GO:0019835)3.30347343
103glutamate metabolic process (GO:0006536)3.29877358
104detection of external biotic stimulus (GO:0098581)3.29628805
105response to muramyl dipeptide (GO:0032495)3.29349943
106cellular amino acid catabolic process (GO:0009063)3.28403226
107positive regulation of lipid catabolic process (GO:0050996)3.27965896
108nicotinamide nucleotide biosynthetic process (GO:0019359)3.27734643
109pyridine nucleotide biosynthetic process (GO:0019363)3.27734643
110NAD biosynthetic process (GO:0009435)3.27712086
111regulation of cholesterol biosynthetic process (GO:0045540)3.26974034
112regulation of cholesterol metabolic process (GO:0090181)3.26539019
113fatty acid oxidation (GO:0019395)3.25058672
114sterol homeostasis (GO:0055092)3.24639556
115complement activation (GO:0006956)3.23794518
116lysine metabolic process (GO:0006553)3.22630501
117lysine catabolic process (GO:0006554)3.22630501
118fatty acid beta-oxidation (GO:0006635)3.21983583
119positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.21382930
120fatty acid catabolic process (GO:0009062)3.20382616
121regulation of leukocyte degranulation (GO:0043300)3.19809919
122complement activation, classical pathway (GO:0006958)3.19762711
123protein-lipid complex assembly (GO:0065005)3.19594792
124short-chain fatty acid metabolic process (GO:0046459)3.18971388
125lipid oxidation (GO:0034440)3.18702001
126glycine metabolic process (GO:0006544)3.17881812
127fatty acid elongation (GO:0030497)3.16474974
128low-density lipoprotein particle remodeling (GO:0034374)3.15517302
129protein activation cascade (GO:0072376)3.15360720
130cellular ketone body metabolic process (GO:0046950)3.14618725
131detection of molecule of bacterial origin (GO:0032490)3.14429238
132monocarboxylic acid catabolic process (GO:0072329)3.14265551
133type I interferon signaling pathway (GO:0060337)3.12647722
134cellular response to type I interferon (GO:0071357)3.12647722
135regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12332408
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08936331
137response to type I interferon (GO:0034340)3.08888215
138regulation of gamma-delta T cell activation (GO:0046643)3.08347205
139germinal center formation (GO:0002467)3.05705768
140regulation of mast cell activation involved in immune response (GO:0033006)3.04623844
141response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02000241
142response to host immune response (GO:0052572)3.02000241
143regulation of B cell receptor signaling pathway (GO:0050855)3.00256704
144myeloid cell activation involved in immune response (GO:0002275)2.97543243
145Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96305136
146positive regulation of Cdc42 GTPase activity (GO:0043089)2.92354881
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92117227
148response to host (GO:0075136)2.92117227
149response to host defenses (GO:0052200)2.92117227
150regulation of T-helper 2 cell differentiation (GO:0045628)2.89365610
151negative regulation of cytokine production involved in immune response (GO:0002719)2.87716945
152mannose metabolic process (GO:0006013)2.87050417
153cellular extravasation (GO:0045123)2.86140750
154leukocyte migration involved in inflammatory response (GO:0002523)2.84097338
155detection of biotic stimulus (GO:0009595)2.83187307
156positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.79881930
157respiratory burst (GO:0045730)2.79528894
158negative regulation of leukocyte mediated immunity (GO:0002704)2.77786871
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75673565
160regulation of T cell tolerance induction (GO:0002664)2.75086509
161myeloid dendritic cell differentiation (GO:0043011)2.74544504
162negative regulation of lymphocyte mediated immunity (GO:0002707)2.74295352
163positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71385805
164antigen processing and presentation via MHC class Ib (GO:0002475)2.70280277
165negative regulation of type 2 immune response (GO:0002829)2.69094631
166positive thymic T cell selection (GO:0045059)2.68996538
167regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67837379
168B cell mediated immunity (GO:0019724)2.67053955
169protein localization to endosome (GO:0036010)2.66612771
170positive regulation of cellular amide metabolic process (GO:0034250)2.66342020
171interferon-gamma-mediated signaling pathway (GO:0060333)2.63846138
172positive regulation of mast cell activation (GO:0033005)2.62307653
173macrophage activation (GO:0042116)2.60210226
174defense response to protozoan (GO:0042832)2.60179036
175regulation of regulated secretory pathway (GO:1903305)2.59367057
176negative regulation of innate immune response (GO:0045824)2.58268170
177regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.57761155
178regulation of natural killer cell mediated immunity (GO:0002715)2.57761155
179modulation by symbiont of host cellular process (GO:0044068)2.57344411
180positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57093917
181positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.56902894
182regulation of gamma-delta T cell differentiation (GO:0045586)2.55553295
183positive regulation of B cell differentiation (GO:0045579)2.55025678
184regulation of type 2 immune response (GO:0002828)2.54545270
185pinocytosis (GO:0006907)2.52983204
186regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.52744676
187leukocyte degranulation (GO:0043299)2.51738845
188myeloid dendritic cell activation (GO:0001773)2.50885932
189regulation of superoxide anion generation (GO:0032928)2.50711125
190regulation of mast cell activation (GO:0033003)2.48887185
191regulation of defense response to virus by virus (GO:0050690)2.46705717
192response to protozoan (GO:0001562)2.45831271
193response to interleukin-15 (GO:0070672)2.44713286
194regulation of tolerance induction (GO:0002643)2.44265760
195thymic T cell selection (GO:0045061)2.43260582
196negative regulation of interleukin-6 production (GO:0032715)2.42558863
197T cell migration (GO:0072678)2.42400660
198positive regulation of type 2 immune response (GO:0002830)2.42090691
199positive regulation of tumor necrosis factor production (GO:0032760)2.40545341
200negative regulation of myeloid cell apoptotic process (GO:0033033)2.40541230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.43844383
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.59909816
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.42519239
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.81088817
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.41165493
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.52994996
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18226919
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75312515
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51805380
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.31708936
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.27703979
12VDR_21846776_ChIP-Seq_THP-1_Human2.91705396
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.60003545
14MYC_22102868_ChIP-Seq_BL_Human2.50723900
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.36230569
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.36218707
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32583318
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30632518
19LXR_22292898_ChIP-Seq_THP-1_Human2.29087019
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18577718
21VDR_24763502_ChIP-Seq_THP-1_Human2.17639912
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14852140
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13723848
24MAF_26560356_Chip-Seq_TH1_Human2.08253343
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03170784
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.01307641
27TCF7_22412390_ChIP-Seq_EML_Mouse1.99508820
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96042324
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92253573
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90211343
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90164847
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89381207
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87790895
34SPI1_23127762_ChIP-Seq_K562_Human1.86133816
35* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85400573
36UTX_26944678_Chip-Seq_JUKART_Human1.85222583
37KDM2B_26808549_Chip-Seq_DND41_Human1.84592295
38* SPI1_23547873_ChIP-Seq_NB4_Human1.78612118
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78225286
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73179663
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70943279
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70369525
43MAF_26560356_Chip-Seq_TH2_Human1.69749761
44* EGR1_19374776_ChIP-ChIP_THP-1_Human1.65925902
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63435265
46RACK7_27058665_Chip-Seq_MCF-7_Human1.59909993
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.57957342
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57616409
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57547426
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55285709
51HTT_18923047_ChIP-ChIP_STHdh_Human1.53653680
52* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53002993
53* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53002993
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.50196892
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49877245
56SCL_19346495_ChIP-Seq_HPC-7_Human1.49723697
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46906880
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.46334256
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45933859
60CLOCK_20551151_ChIP-Seq_293T_Human1.43493094
61GATA1_22025678_ChIP-Seq_K562_Human1.42021352
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41321228
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40858467
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39689718
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39274354
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.39076000
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37650807
68NCOR1_26117541_ChIP-Seq_K562_Human1.35746776
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34768489
70MYB_26560356_Chip-Seq_TH2_Human1.33652953
71* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33508689
72BCL6_27268052_Chip-Seq_Bcells_Human1.32850588
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32725273
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31810835
75BCOR_27268052_Chip-Seq_Bcells_Human1.31683381
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.31017445
77MYB_26560356_Chip-Seq_TH1_Human1.30779296
78P68_20966046_ChIP-Seq_HELA_Human1.28346998
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28164547
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27767364
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.27367987
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.27331085
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26226912
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25354904
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24582380
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.24386988
87EGR1_19032775_ChIP-ChIP_M12_Human1.23285144
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23269013
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.22794056
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18259708
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18214263
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17666678
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17654101
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17286252
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15565257
96HNF4A_19822575_ChIP-Seq_HepG2_Human1.15060101
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15001330
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13915298
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.12768611
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08960233
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07828478
102KDM2B_26808549_Chip-Seq_K562_Human1.07398091
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06356225
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06146740
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04740012
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02832020
107SMC4_20622854_ChIP-Seq_HELA_Human1.02178681
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01061322
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00909884
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00469756
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00358073
112* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00059066
113SOX2_20726797_ChIP-Seq_SW620_Human0.95145937
114VDR_24787735_ChIP-Seq_THP-1_Human0.95125880
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92291173
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90065333
117RUNX_20019798_ChIP-Seq_JUKART_Human0.89477478
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.89454758
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89241062
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.88870377
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85793741
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84589363
123CJUN_26792858_Chip-Seq_BT549_Human0.84475855
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84380960
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82413289
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.80670253
127TP63_17297297_ChIP-ChIP_HaCaT_Human0.80550502
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78977473
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77807351
130GATA4_25053715_ChIP-Seq_YYC3_Human0.77599718
131MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77014132
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74865444
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74257755
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.73775643
135TAF15_26573619_Chip-Seq_HEK293_Human0.73739357
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73150919
137GATA1_19941826_ChIP-Seq_K562_Human0.72808425
138TP53_16413492_ChIP-PET_HCT116_Human0.72637394
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70767293
140GATA2_19941826_ChIP-Seq_K562_Human0.70289539
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69589113
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68421806
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66975020
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66603227
145GATA3_26560356_Chip-Seq_TH2_Human0.64582816
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62729298
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62003059
148SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.60425320
149CBP_21632823_ChIP-Seq_H3396_Human0.60414973
150STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.59926804
151SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.59685127
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.59233045
153P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58705481
154* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57700436
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.57143619
156VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.56429539
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.55829450
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.55382709
159TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54908831
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54799369
161EOMES_21245162_ChIP-Seq_HESCs_Human0.54595885
162* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.54495651
163* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.54495651
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.54421872
165ER_23166858_ChIP-Seq_MCF-7_Human0.54267860
166EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53040935
167CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.49197811
168GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.49057302
169CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.48626978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.84947691
2MP0005360_urolithiasis5.93435568
3MP0005085_abnormal_gallbladder_physiolo5.72559873
4MP0005365_abnormal_bile_salt4.93761861
5MP0008875_abnormal_xenobiotic_pharmacok3.95286262
6MP0003806_abnormal_nucleotide_metabolis3.78269625
7MP0003303_peritoneal_inflammation3.71318603
8MP0003252_abnormal_bile_duct3.52502375
9MP0003195_calcinosis3.50527744
10MP0010329_abnormal_lipoprotein_level3.15761150
11MP0009840_abnormal_foam_cell2.91713672
12MP0005083_abnormal_biliary_tract2.70294869
13MP0008260_abnormal_autophagy2.45652947
14MP0005671_abnormal_response_to2.42890016
15MP0003172_abnormal_lysosome_physiology2.38879159
16MP0005332_abnormal_amino_acid2.35468137
17MP0001666_abnormal_nutrient_absorption2.32638825
18MP0003191_abnormal_cellular_cholesterol2.19490858
19* MP0002420_abnormal_adaptive_immunity2.03137054
20* MP0001819_abnormal_immune_cell2.01746817
21MP0000858_altered_metastatic_potential1.99519073
22MP0003868_abnormal_feces_composition1.91721508
23MP0003763_abnormal_thymus_physiology1.91066460
24MP0009278_abnormal_bone_marrow1.90879019
25* MP0000609_abnormal_liver_physiology1.89786044
26MP0002118_abnormal_lipid_homeostasis1.88128573
27MP0005408_hypopigmentation1.85856736
28MP0002138_abnormal_hepatobiliary_system1.85103617
29MP0009333_abnormal_splenocyte_physiolog1.82183586
30MP0010155_abnormal_intestine_physiology1.79618603
31MP0003690_abnormal_glial_cell1.71803848
32MP0000604_amyloidosis1.68945187
33MP0003186_abnormal_redox_activity1.66311743
34MP0003724_increased_susceptibility_to1.62869934
35* MP0002398_abnormal_bone_marrow1.61368469
36MP0002405_respiratory_system_inflammati1.60691065
37MP0005451_abnormal_body_composition1.59574159
38MP0004381_abnormal_hair_follicle1.58699615
39MP0003656_abnormal_erythrocyte_physiolo1.56707484
40* MP0000716_abnormal_immune_system1.54746443
41MP0004019_abnormal_vitamin_homeostasis1.53264228
42* MP0005319_abnormal_enzyme/_coenzyme1.46129723
43* MP0009764_decreased_sensitivity_to1.45376493
44MP0005058_abnormal_lysosome_morphology1.42129522
45MP0008438_abnormal_cutaneous_collagen1.41955413
46MP0002998_abnormal_bone_remodeling1.41227924
47MP0009697_abnormal_copulation1.41198999
48MP0003436_decreased_susceptibility_to1.35321911
49MP0001764_abnormal_homeostasis1.34813880
50* MP0005584_abnormal_enzyme/coenzyme_acti1.34607446
51MP0001835_abnormal_antigen_presentation1.33722531
52* MP0002429_abnormal_blood_cell1.33639460
53MP0005397_hematopoietic_system_phenotyp1.33074032
54MP0001545_abnormal_hematopoietic_system1.33074032
55* MP0002722_abnormal_immune_system1.32088356
56MP0003566_abnormal_cell_adhesion1.30746329
57MP0003828_pulmonary_edema1.29567053
58* MP0000689_abnormal_spleen_morphology1.28942607
59MP0000465_gastrointestinal_hemorrhage1.22764795
60MP0008004_abnormal_stomach_pH1.20552606
61MP0004130_abnormal_muscle_cell1.19237004
62MP0001851_eye_inflammation1.18881417
63MP0009643_abnormal_urine_homeostasis1.18711823
64MP0002132_abnormal_respiratory_system1.18483118
65* MP0009763_increased_sensitivity_to1.18062465
66MP0002419_abnormal_innate_immunity1.17122144
67MP0005464_abnormal_platelet_physiology1.17047490
68MP0006082_CNS_inflammation1.16215505
69* MP0008469_abnormal_protein_level1.15872224
70MP0002254_reproductive_system_inflammat1.13992286
71MP0003448_altered_tumor_morphology1.12660284
72MP0009785_altered_susceptibility_to1.12149192
73MP0001873_stomach_inflammation1.11872388
74* MP0000598_abnormal_liver_morphology1.08424562
75MP0000920_abnormal_myelination1.06800691
76* MP0000703_abnormal_thymus_morphology1.06170868
77MP0002876_abnormal_thyroid_physiology1.04135702
78MP0003329_amyloid_beta_deposits1.04022240
79MP0003091_abnormal_cell_migration1.03956298
80MP0003866_abnormal_defecation1.03753072
81MP0003011_delayed_dark_adaptation1.02413781
82MP0005166_decreased_susceptibility_to1.00984475
83MP0005164_abnormal_response_to1.00401510
84MP0000490_abnormal_crypts_of0.99478377
85MP0001849_ear_inflammation0.97697798
86* MP0009765_abnormal_xenobiotic_induced0.96620591
87MP0002877_abnormal_melanocyte_morpholog0.95682809
88MP0005076_abnormal_cell_differentiation0.95450689
89MP0005390_skeleton_phenotype0.94774182
90MP0004510_myositis0.94629206
91MP0005025_abnormal_response_to0.93883725
92MP0004883_abnormal_blood_vessel0.93217378
93MP0003279_aneurysm0.90213163
94MP0005023_abnormal_wound_healing0.89224661
95MP0002796_impaired_skin_barrier0.88742957
96MP0001663_abnormal_digestive_system0.88174921
97MP0003183_abnormal_peptide_metabolism0.86416209
98MP0001533_abnormal_skeleton_physiology0.85144664
99MP0005000_abnormal_immune_tolerance0.84468624
100MP0002933_joint_inflammation0.82540244
101MP0003795_abnormal_bone_structure0.80458228
102MP0002332_abnormal_exercise_endurance0.80323226
103MP0000249_abnormal_blood_vessel0.79797861
104MP0002148_abnormal_hypersensitivity_rea0.79571835
105MP0001790_abnormal_immune_system0.78037683
106MP0005387_immune_system_phenotype0.78037683
107* MP0009642_abnormal_blood_homeostasis0.76778791
108* MP0001845_abnormal_inflammatory_respons0.76567715
109* MP0008874_decreased_physiological_sensi0.76348851
110* MP0001800_abnormal_humoral_immune0.75423538
111MP0002168_other_aberrant_phenotype0.75226768
112MP0003300_gastrointestinal_ulcer0.74987175
113MP0001958_emphysema0.74098092
114MP0004185_abnormal_adipocyte_glucose0.73691657
115MP0001853_heart_inflammation0.71388541
116MP0005395_other_phenotype0.71382397
117MP0005647_abnormal_sex_gland0.68965042
118MP0009379_abnormal_foot_pigmentation0.68057167
119* MP0003453_abnormal_keratinocyte_physiol0.67829241
120* MP0004947_skin_inflammation0.67584904
121MP0003705_abnormal_hypodermis_morpholog0.67338456
122MP0002295_abnormal_pulmonary_circulatio0.67061674
123MP0002452_abnormal_antigen_presenting0.65741758
124MP0002396_abnormal_hematopoietic_system0.64899003
125MP0005171_absent_coat_pigmentation0.64688587
126MP0002166_altered_tumor_susceptibility0.64561303
127MP0004808_abnormal_hematopoietic_stem0.64550837
128MP0005334_abnormal_fat_pad0.64408437
129MP0005636_abnormal_mineral_homeostasis0.64108309
130MP0001661_extended_life_span0.61946907
131MP0002928_abnormal_bile_duct0.60574464
132MP0004858_abnormal_nervous_system0.60536108
133* MP0008873_increased_physiological_sensi0.60246880
134* MP0002723_abnormal_immune_serum0.60159231
135MP0005084_abnormal_gallbladder_morpholo0.59052116
136MP0002136_abnormal_kidney_physiology0.58112266
137MP0005376_homeostasis/metabolism_phenot0.55759117
138MP0002060_abnormal_skin_morphology0.55073527
139MP0005275_abnormal_skin_tensile0.54959938
140* MP0002078_abnormal_glucose_homeostasis0.54525646
141MP0002971_abnormal_brown_adipose0.54107318
142MP0001243_abnormal_dermal_layer0.53277612
143MP0003075_altered_response_to0.51548539
144MP0000685_abnormal_immune_system0.51504424
145MP0000343_altered_response_to0.50324823
146MP0001542_abnormal_bone_strength0.49719460
147MP0005310_abnormal_salivary_gland0.49693140
148MP0002090_abnormal_vision0.49001622
149MP0006036_abnormal_mitochondrial_physio0.47917696
150MP0001324_abnormal_eye_pigmentation0.47771470
151MP0005666_abnormal_adipose_tissue0.47113268

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.88391771
2Intrahepatic cholestasis (HP:0001406)5.81622719
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.74737261
4Prolonged partial thromboplastin time (HP:0003645)5.68196138
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.61582169
6Xanthomatosis (HP:0000991)5.52611899
7Eczematoid dermatitis (HP:0000976)4.99805731
8Complement deficiency (HP:0004431)4.99707990
9Hypobetalipoproteinemia (HP:0003563)4.94610396
10Hyperlipoproteinemia (HP:0010980)4.85519390
11Abnormality of the common coagulation pathway (HP:0010990)4.84101070
12Joint hemorrhage (HP:0005261)4.46482042
13Abnormality of complement system (HP:0005339)3.97254610
14Epidermoid cyst (HP:0200040)3.83745076
15Myositis (HP:0100614)3.75384781
16Prolonged bleeding time (HP:0003010)3.70424579
17Hypolipoproteinemia (HP:0010981)3.69243336
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66288978
19Abnormality of glycolipid metabolism (HP:0010969)3.64233003
20Abnormality of liposaccharide metabolism (HP:0010968)3.64233003
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.64233003
22Hyperammonemia (HP:0001987)3.60829964
23Fat malabsorption (HP:0002630)3.60339887
24Petechiae (HP:0000967)3.57995959
25Orchitis (HP:0100796)3.57425654
26Myocardial infarction (HP:0001658)3.54928647
27Hyperglycinemia (HP:0002154)3.54470623
28Abnormality of methionine metabolism (HP:0010901)3.53744777
29Abnormality of fatty-acid metabolism (HP:0004359)3.48199954
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.44456362
31Abnormality of the intrinsic pathway (HP:0010989)3.43143817
32Abnormality of glycine metabolism (HP:0010895)3.37949456
33Abnormality of serine family amino acid metabolism (HP:0010894)3.37949456
34Systemic lupus erythematosus (HP:0002725)3.34565411
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34289229
36Chronic obstructive pulmonary disease (HP:0006510)3.32856708
37Obstructive lung disease (HP:0006536)3.32856708
38Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32833735
39Hyperglycinuria (HP:0003108)3.32567207
40Recurrent gram-negative bacterial infections (HP:0005420)3.30738611
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.30449735
42Hypoalphalipoproteinemia (HP:0003233)3.23226156
43Dysostosis multiplex (HP:0000943)3.18277593
44Epistaxis (HP:0000421)3.17531736
45Hypoglycemic coma (HP:0001325)3.16770973
46Optic neuritis (HP:0100653)3.12645406
47Retrobulbar optic neuritis (HP:0100654)3.12645406
48Hypercholesterolemia (HP:0003124)3.09626142
49Elevated erythrocyte sedimentation rate (HP:0003565)3.07933794
50Conjugated hyperbilirubinemia (HP:0002908)3.04921058
51Stomatitis (HP:0010280)3.02190401
52Mediastinal lymphadenopathy (HP:0100721)2.99070411
53Steatorrhea (HP:0002570)2.93140810
54Abnormal platelet volume (HP:0011876)2.92824706
55Increased cerebral lipofuscin (HP:0011813)2.91250825
56Spontaneous abortion (HP:0005268)2.90064006
57Ketosis (HP:0001946)2.84687972
58Gastrointestinal infarctions (HP:0005244)2.84555840
59Gingival bleeding (HP:0000225)2.81089593
60Spontaneous hematomas (HP:0007420)2.80501806
61Mitral stenosis (HP:0001718)2.79848759
62Glomerulonephritis (HP:0000099)2.78188703
63Meningitis (HP:0001287)2.77681928
64Amyloidosis (HP:0011034)2.76783388
65Cellulitis (HP:0100658)2.76655951
66Skin nodule (HP:0200036)2.74072404
67Abnormality of serum amino acid levels (HP:0003112)2.73965417
68Abnormal cartilage morphology (HP:0002763)2.72344276
69Increased IgE level (HP:0003212)2.71500637
70Recurrent fungal infections (HP:0002841)2.70198207
71Loss of speech (HP:0002371)2.68951013
72Abnormality of pyrimidine metabolism (HP:0004353)2.63304885
73Gingivitis (HP:0000230)2.62081499
74* Hemorrhage of the eye (HP:0011885)2.60998111
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60270514
76Abnormality of polysaccharide metabolism (HP:0011012)2.60270514
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60270514
78Recurrent skin infections (HP:0001581)2.54204232
79Urinary glycosaminoglycan excretion (HP:0003541)2.49128854
80Mucopolysacchariduria (HP:0008155)2.49128854
81Hypochromic microcytic anemia (HP:0004840)2.48127674
82Generalized aminoaciduria (HP:0002909)2.47290931
83Vasculitis (HP:0002633)2.46417460
84Increased mean platelet volume (HP:0011877)2.46296426
85Multiple enchondromatosis (HP:0005701)2.44271682
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.43382513
87Urticaria (HP:0001025)2.40427935
88Hyperbilirubinemia (HP:0002904)2.35876480
89Pustule (HP:0200039)2.32656910
90Delayed CNS myelination (HP:0002188)2.30818280
91Abnormality of iron homeostasis (HP:0011031)2.23947996
92Abnormal platelet function (HP:0011869)2.23409737
93Impaired platelet aggregation (HP:0003540)2.23409737
94Vertebral compression fractures (HP:0002953)2.22341680
95Episodic fever (HP:0001954)2.22187215
96Gastrointestinal inflammation (HP:0004386)2.21166783
97Hepatocellular carcinoma (HP:0001402)2.20203669
98Abnormality of nucleobase metabolism (HP:0010932)2.19345538
99Recurrent viral infections (HP:0004429)2.19314694
100Esophageal varix (HP:0002040)2.18372620
101Keratoconjunctivitis sicca (HP:0001097)2.17751431
102Pulmonary infiltrates (HP:0002113)2.16815250
103Hepatosplenomegaly (HP:0001433)2.16633504
104Nephritis (HP:0000123)2.15838723
105Vascular calcification (HP:0004934)2.14318583
106Inflammation of the large intestine (HP:0002037)2.13966606
107Hypertensive crisis (HP:0100735)2.13700117
108Abnormality of transition element cation homeostasis (HP:0011030)2.09224595
109Proximal tubulopathy (HP:0000114)2.08271657
110Ketoacidosis (HP:0001993)2.07480839
111Abnormal gallbladder morphology (HP:0012437)2.07334535
112* Encephalitis (HP:0002383)2.07295701
113Abnormal delayed hypersensitivity skin test (HP:0002963)2.06738591
114Fatigue (HP:0012378)2.05491718
115Lethargy (HP:0001254)2.04232686
116Renal cortical cysts (HP:0000803)2.03984312
117Recurrent cutaneous fungal infections (HP:0011370)2.03980564
118Chronic mucocutaneous candidiasis (HP:0002728)2.03980564
119Arterial thrombosis (HP:0004420)2.03108983
120Chest pain (HP:0100749)2.02550122
121Interstitial pulmonary disease (HP:0006530)2.02313020
122Thrombophlebitis (HP:0004418)2.02055395
123Colitis (HP:0002583)2.02024871
124Anorexia (HP:0002039)2.00833959
125Pancreatitis (HP:0001733)2.00831651
126Cardiovascular calcification (HP:0011915)2.00622953
127Distal lower limb amyotrophy (HP:0008944)1.99172091
128Hypophosphatemic rickets (HP:0004912)1.98464047
129Cholelithiasis (HP:0001081)1.97472127
130Abnormality of purine metabolism (HP:0004352)1.97365865
131Axonal loss (HP:0003447)1.97078725
132Opisthotonus (HP:0002179)1.96667851
133Abnormality of macrophages (HP:0004311)1.96533095
134Polycythemia (HP:0001901)1.96468871
135Nausea (HP:0002018)1.96435722
136Hemoptysis (HP:0002105)1.95641918
137Increased serum ferritin (HP:0003281)1.95263555
138Purpura (HP:0000979)1.95118141
139Rickets (HP:0002748)1.94570081
140Glomerulopathy (HP:0100820)1.94351006
141Dicarboxylic aciduria (HP:0003215)1.93598740
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93598740
143Spastic diplegia (HP:0001264)1.93582510
144Abnormality of the Achilles tendon (HP:0005109)1.92472500
145Acanthocytosis (HP:0001927)1.91945449
146Pulmonary embolism (HP:0002204)1.91382185
147Keratoconjunctivitis (HP:0001096)1.89990298
148Progressive neurologic deterioration (HP:0002344)1.89465719
149Vacuolated lymphocytes (HP:0001922)1.88473581
150Fair hair (HP:0002286)1.88431642
151Metabolic acidosis (HP:0001942)1.87785815
152Neuronal loss in central nervous system (HP:0002529)1.87711468
153Cerebral hemorrhage (HP:0001342)1.84312152
154Achilles tendon contracture (HP:0001771)1.84205354
155Spastic paraparesis (HP:0002313)1.84134709
156Increased connective tissue (HP:0009025)1.83395548
157Hydroxyprolinuria (HP:0003080)1.82592788
158Abnormality of proline metabolism (HP:0010907)1.82592788
159Osteomyelitis (HP:0002754)1.81783793
160Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81544578
161Hypochromic anemia (HP:0001931)1.80361589
162Cholecystitis (HP:0001082)1.79911005
163Abnormal gallbladder physiology (HP:0012438)1.79911005
164Slow saccadic eye movements (HP:0000514)1.79570862
165Recurrent bacterial skin infections (HP:0005406)1.79563081
166Abnormal enzyme/coenzyme activity (HP:0012379)1.79525802
167T lymphocytopenia (HP:0005403)1.79208445
168Distal lower limb muscle weakness (HP:0009053)1.79131871
169Menorrhagia (HP:0000132)1.79017379
170Joint swelling (HP:0001386)1.78574551
171Gastrointestinal stroma tumor (HP:0100723)1.77998467
172Irritability (HP:0000737)1.77590169
173Progressive external ophthalmoplegia (HP:0000590)1.74810627
174Erythroderma (HP:0001019)1.73594466
175Elevated alkaline phosphatase (HP:0003155)1.73454507
176Hypertriglyceridemia (HP:0002155)1.73023625
177Neurofibrillary tangles (HP:0002185)1.71910474
178Peritonitis (HP:0002586)1.71864593
179Recurrent abscess formation (HP:0002722)1.70859809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.75292991
2IRAK43.60233181
3EPHB13.04094687
4TRIB32.72785617
5MAP2K32.65421227
6SIK12.57652028
7FLT32.55581427
8MST42.49285922
9BCKDK2.41567567
10TNIK2.17786544
11MAP3K142.17628002
12IRAK22.12273678
13FGFR42.12180488
14TAOK22.04466085
15PKN21.99949174
16ZAP701.98930246
17ABL21.95811260
18MAP3K111.94167404
19NEK91.93048685
20PBK1.90250946
21IRAK11.82149247
22GRK61.81654529
23TESK21.81203729
24TAOK11.67689567
25SMG11.67254560
26PKN11.63522387
27TAOK31.63035891
28FES1.52682711
29SIK31.51915250
30ERBB41.50242404
31ZAK1.48045734
32TYK21.47299027
33MAP3K131.47192368
34CSF1R1.45157485
35INSRR1.44358828
36JAK11.41399775
37BTK1.38139473
38MST1R1.37926837
39TBK11.36620162
40CAMKK21.33357059
41TNK21.31858764
42ERN11.30837700
43CSK1.28967977
44FRK1.24017731
45TESK11.21878453
46BMX1.20370023
47MAP3K11.18392888
48PIK3CG1.17314737
49BCR1.13634814
50IKBKE1.12639064
51STK391.09846095
52MARK31.09324152
53STK41.06645898
54SIK21.06319672
55* IKBKB1.05820757
56MET1.05056206
57RIPK11.04935052
58ICK1.04189280
59STK101.03753786
60PRKD21.01982655
61ARAF1.01317022
62KSR20.98471817
63BLK0.98331597
64GRK70.96154903
65PIM20.96025204
66PAK40.94670373
67MARK10.93052940
68CDC42BPA0.93032202
69EPHA20.93018062
70EIF2AK30.90803253
71MARK20.88229665
72MAP3K30.86926137
73BRSK20.85867505
74KIT0.85170558
75MATK0.84983487
76TGFBR20.84484028
77JAK20.82264477
78EIF2AK10.80810170
79STK160.79145760
80CLK10.77756906
81PTK60.77633902
82BMPR20.77318213
83PRKCQ0.75154122
84EPHA30.74760935
85EIF2AK20.71345454
86LYN0.70978971
87TTN0.70773414
88RIPK40.70067323
89PLK40.65969965
90FGFR20.65844361
91MAP3K60.65582857
92ABL10.64275648
93ROCK20.64201218
94HCK0.61240322
95MOS0.60430608
96PDPK10.60301316
97NUAK10.60114008
98HIPK20.59478462
99JAK30.59053022
100NME20.57945481
101RPS6KA20.57810363
102GRK10.57284999
103MAPK40.56848599
104TXK0.56613880
105KDR0.56440257
106MAPK110.56374751
107RPS6KC10.56212701
108RPS6KL10.56212701
109CDK120.55782487
110ITK0.54858076
111MAPK120.54639069
112CAMK2G0.53833566
113LRRK20.53769968
114MAP3K80.52167240
115PRPF4B0.51723999
116MAP3K50.50778292
117PTK2B0.50728463
118CSNK1A1L0.50236962
119STK30.48953987
120OXSR10.48026868
121CAMK2B0.47715999
122SCYL20.47557866
123DYRK1B0.46806438
124CASK0.45894135
125MAP3K20.45700900
126MAPKAPK20.45668641
127PAK10.44550558
128CDK40.44255206
129INSR0.43831163
130LCK0.43730904
131SYK0.43637299
132RET0.43511188
133BUB10.43318138
134CHUK0.42734977
135PIM10.42718312
136ROCK10.42289038
137NLK0.42283955
138PRKG20.41936705
139PAK30.41535363
140DDR20.41493375
141MAPK70.41352379
142FYN0.40927217
143PRKCD0.40716702
144BRAF0.40333369
145FGR0.39959562
146MAP2K20.39215175
147RPS6KA60.38303560
148CAMK2D0.38009442
149MAP4K10.37886586
150PRKACG0.37803009
151CSNK1G30.37766039
152ILK0.37550650
153MAPKAPK30.36976504
154PRKCH0.36903350
155CDK60.36525030
156PRKAA20.36295719
157EGFR0.35036833
158STK380.34465035
159PDK10.34428768

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33016617
2Complement and coagulation cascades_Homo sapiens_hsa046102.89519650
3Other glycan degradation_Homo sapiens_hsa005112.88520749
4Nitrogen metabolism_Homo sapiens_hsa009102.88284546
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88088296
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68662027
7* Osteoclast differentiation_Homo sapiens_hsa043802.68256502
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59302115
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57350580
10Arginine biosynthesis_Homo sapiens_hsa002202.56296918
11Tryptophan metabolism_Homo sapiens_hsa003802.50990269
12Staphylococcus aureus infection_Homo sapiens_hsa051502.50794468
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49223137
14Fatty acid degradation_Homo sapiens_hsa000712.42552331
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37552002
16Peroxisome_Homo sapiens_hsa041462.32994516
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20594969
18Steroid biosynthesis_Homo sapiens_hsa001002.19392254
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05269683
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.99416860
21Fatty acid elongation_Homo sapiens_hsa000621.97505423
22Histidine metabolism_Homo sapiens_hsa003401.97248687
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97211966
24* B cell receptor signaling pathway_Homo sapiens_hsa046621.97181821
25Chemical carcinogenesis_Homo sapiens_hsa052041.95959789
26Butanoate metabolism_Homo sapiens_hsa006501.94753600
27Fatty acid metabolism_Homo sapiens_hsa012121.94269252
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.93662620
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88420331
30PPAR signaling pathway_Homo sapiens_hsa033201.88087779
31Tuberculosis_Homo sapiens_hsa051521.86178872
32* Acute myeloid leukemia_Homo sapiens_hsa052211.70639463
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69966328
34beta-Alanine metabolism_Homo sapiens_hsa004101.69312848
35Autoimmune thyroid disease_Homo sapiens_hsa053201.67694094
36Propanoate metabolism_Homo sapiens_hsa006401.65092501
37Retinol metabolism_Homo sapiens_hsa008301.61266190
38Sulfur metabolism_Homo sapiens_hsa009201.57752312
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54645963
40Hematopoietic cell lineage_Homo sapiens_hsa046401.52665494
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51128592
42* Toxoplasmosis_Homo sapiens_hsa051451.50612374
43Vitamin B6 metabolism_Homo sapiens_hsa007501.50248569
44* TNF signaling pathway_Homo sapiens_hsa046681.50024640
45Phenylalanine metabolism_Homo sapiens_hsa003601.48016594
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47605552
47Caffeine metabolism_Homo sapiens_hsa002321.45757811
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.45752799
49Influenza A_Homo sapiens_hsa051641.45399757
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44207986
51* Shigellosis_Homo sapiens_hsa051311.40420298
52Antigen processing and presentation_Homo sapiens_hsa046121.38518667
53Tyrosine metabolism_Homo sapiens_hsa003501.37607873
54* Primary immunodeficiency_Homo sapiens_hsa053401.36457832
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35687940
56Salmonella infection_Homo sapiens_hsa051321.34146381
57* Chemokine signaling pathway_Homo sapiens_hsa040621.32571203
58Legionellosis_Homo sapiens_hsa051341.30319579
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29173819
60ABC transporters_Homo sapiens_hsa020101.28671572
61* T cell receptor signaling pathway_Homo sapiens_hsa046601.28530195
62* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26754467
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23378207
64Non-small cell lung cancer_Homo sapiens_hsa052231.21206363
65* Herpes simplex infection_Homo sapiens_hsa051681.20866685
66VEGF signaling pathway_Homo sapiens_hsa043701.19990301
67Platelet activation_Homo sapiens_hsa046111.18058579
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17816925
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17587748
70* Chronic myeloid leukemia_Homo sapiens_hsa052201.17261837
71* Apoptosis_Homo sapiens_hsa042101.15921818
72* Hepatitis B_Homo sapiens_hsa051611.15314087
73Glutathione metabolism_Homo sapiens_hsa004801.15151681
74Selenocompound metabolism_Homo sapiens_hsa004501.12558923
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.11119146
76Folate biosynthesis_Homo sapiens_hsa007901.11066062
77Starch and sucrose metabolism_Homo sapiens_hsa005001.07730559
78Type I diabetes mellitus_Homo sapiens_hsa049401.07620422
79Bladder cancer_Homo sapiens_hsa052191.06865880
80* Pancreatic cancer_Homo sapiens_hsa052121.06432209
81Bile secretion_Homo sapiens_hsa049761.05546885
82Asthma_Homo sapiens_hsa053101.05001392
83Fat digestion and absorption_Homo sapiens_hsa049751.04303824
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03649473
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02437360
86Jak-STAT signaling pathway_Homo sapiens_hsa046301.02109081
87Endocytosis_Homo sapiens_hsa041441.01839952
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01652639
89African trypanosomiasis_Homo sapiens_hsa051430.98995284
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93866701
91Pyruvate metabolism_Homo sapiens_hsa006200.91826828
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91441263
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91363090
94Arginine and proline metabolism_Homo sapiens_hsa003300.90819700
95Galactose metabolism_Homo sapiens_hsa000520.89236163
96Fructose and mannose metabolism_Homo sapiens_hsa000510.89049919
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.87604092
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85825951
99Carbon metabolism_Homo sapiens_hsa012000.83763985
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.82391381
101Renal cell carcinoma_Homo sapiens_hsa052110.81204870
102Notch signaling pathway_Homo sapiens_hsa043300.77537177
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72757377
104* Epstein-Barr virus infection_Homo sapiens_hsa051690.72193953
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71269766
106* Viral carcinogenesis_Homo sapiens_hsa052030.71160873
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.70241772
108Biosynthesis of amino acids_Homo sapiens_hsa012300.68872084
109Vitamin digestion and absorption_Homo sapiens_hsa049770.65993626
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.63145406
111Sulfur relay system_Homo sapiens_hsa041220.63035732
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.62770332
113Prolactin signaling pathway_Homo sapiens_hsa049170.62442098
114* HTLV-I infection_Homo sapiens_hsa051660.62195452
115Endometrial cancer_Homo sapiens_hsa052130.59942789
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.57493977
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.55903689
118Fatty acid biosynthesis_Homo sapiens_hsa000610.52895862
119HIF-1 signaling pathway_Homo sapiens_hsa040660.52412737
120mTOR signaling pathway_Homo sapiens_hsa041500.52028531
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51750534
122Prion diseases_Homo sapiens_hsa050200.49728043
123Vibrio cholerae infection_Homo sapiens_hsa051100.48109037
124Choline metabolism in cancer_Homo sapiens_hsa052310.47305723
125Metabolic pathways_Homo sapiens_hsa011000.46303287
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45996996
127Linoleic acid metabolism_Homo sapiens_hsa005910.45473658
128Insulin signaling pathway_Homo sapiens_hsa049100.44043730
129Ether lipid metabolism_Homo sapiens_hsa005650.43895267
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43105111
131Pentose phosphate pathway_Homo sapiens_hsa000300.43003926
132Glycerolipid metabolism_Homo sapiens_hsa005610.42505100
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42177963
134Glioma_Homo sapiens_hsa052140.41952895
135ErbB signaling pathway_Homo sapiens_hsa040120.38419721
136Malaria_Homo sapiens_hsa051440.37718409
137* Adipocytokine signaling pathway_Homo sapiens_hsa049200.37278606
138GnRH signaling pathway_Homo sapiens_hsa049120.37123082
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37030342
140Focal adhesion_Homo sapiens_hsa045100.35319687
141Thyroid cancer_Homo sapiens_hsa052160.35147080
142One carbon pool by folate_Homo sapiens_hsa006700.33605802
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31500342
144Lysosome_Homo sapiens_hsa041420.30783664
145Rheumatoid arthritis_Homo sapiens_hsa053230.27817371
146Arachidonic acid metabolism_Homo sapiens_hsa005900.26603361
147Phagosome_Homo sapiens_hsa041450.25419222
148Pertussis_Homo sapiens_hsa051330.24907282
149Insulin resistance_Homo sapiens_hsa049310.23530568
150Lysine degradation_Homo sapiens_hsa003100.23350770
151* NF-kappa B signaling pathway_Homo sapiens_hsa040640.22122355
152Protein export_Homo sapiens_hsa030600.17749113
153* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16458597
154* Hepatitis C_Homo sapiens_hsa051600.13610683
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13509200
156Graft-versus-host disease_Homo sapiens_hsa053320.12938994
157* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11753109
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11658073
159Leishmaniasis_Homo sapiens_hsa051400.11355046
160Allograft rejection_Homo sapiens_hsa053300.09198102
161Intestinal immune network for IgA production_Homo sapiens_hsa046720.08300073
162Collecting duct acid secretion_Homo sapiens_hsa049660.07211572
163Viral myocarditis_Homo sapiens_hsa054160.07207159
164* NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07139956
165Glycerophospholipid metabolism_Homo sapiens_hsa005640.05567839
166Sphingolipid metabolism_Homo sapiens_hsa006000.04166309
167* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.03819690
168Measles_Homo sapiens_hsa051620.03408433
169Amoebiasis_Homo sapiens_hsa051460.03019470
170* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.03009763
171Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.02998494

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