IKBKGP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.90486176
2response to peptidoglycan (GO:0032494)4.72817920
3positive regulation by symbiont of host defense response (GO:0052509)4.54381364
4modulation by symbiont of host defense response (GO:0052031)4.54381364
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.54381364
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.54381364
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.54381364
8modulation by symbiont of host immune response (GO:0052553)4.54381364
9negative regulation of cell killing (GO:0031342)4.17679793
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17679793
11response to muramyl dipeptide (GO:0032495)4.00853542
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.89504041
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88854828
14neutrophil activation involved in immune response (GO:0002283)3.87260849
15negative regulation of erythrocyte differentiation (GO:0045647)3.86896576
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81047753
17antigen processing and presentation of endogenous antigen (GO:0019883)3.76400493
18regulation of interferon-beta biosynthetic process (GO:0045357)3.76140633
19macrophage activation involved in immune response (GO:0002281)3.72583593
20positive thymic T cell selection (GO:0045059)3.68634495
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.53502834
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51661212
23regulation of gamma-delta T cell activation (GO:0046643)3.51415110
24leukocyte aggregation (GO:0070486)3.41579949
25negative regulation of interleukin-12 production (GO:0032695)3.39481320
26detection of other organism (GO:0098543)3.38234454
27cellular extravasation (GO:0045123)3.31480867
28thymic T cell selection (GO:0045061)3.29237052
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24949225
30detection of molecule of bacterial origin (GO:0032490)3.24813426
31detection of bacterium (GO:0016045)3.24290008
32regulation of B cell receptor signaling pathway (GO:0050855)3.23650389
33respiratory burst (GO:0045730)3.21986407
34regulation of mast cell degranulation (GO:0043304)3.21704614
35response to host immune response (GO:0052572)3.17574604
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17574604
37response to host (GO:0075136)3.14530767
38response to host defenses (GO:0052200)3.14530767
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14530767
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12127663
41positive regulation of B cell differentiation (GO:0045579)3.11801769
42negative thymic T cell selection (GO:0045060)3.11068964
43regulation of leukocyte degranulation (GO:0043300)3.08423728
44NIK/NF-kappaB signaling (GO:0038061)3.08338713
45neutrophil activation (GO:0042119)3.05852826
46granulocyte activation (GO:0036230)3.03774819
47germinal center formation (GO:0002467)3.03197736
48detection of external biotic stimulus (GO:0098581)3.03103436
49immunoglobulin mediated immune response (GO:0016064)3.03091225
50protein localization to endosome (GO:0036010)3.02549758
51regulation of gamma-delta T cell differentiation (GO:0045586)3.01875106
52actin nucleation (GO:0045010)3.00877625
53response to laminar fluid shear stress (GO:0034616)2.99247244
54T cell selection (GO:0045058)2.99198388
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98009135
56negative T cell selection (GO:0043383)2.96984962
57positive T cell selection (GO:0043368)2.94090405
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90242712
59regulation of T cell tolerance induction (GO:0002664)2.88573589
60mannose metabolic process (GO:0006013)2.81932989
61regulation of mast cell activation involved in immune response (GO:0033006)2.81853765
62B cell receptor signaling pathway (GO:0050853)2.81670101
63response to interleukin-15 (GO:0070672)2.80601507
64cellular response to type I interferon (GO:0071357)2.77532310
65type I interferon signaling pathway (GO:0060337)2.77532310
66regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77208253
67response to type I interferon (GO:0034340)2.75205565
68regulation of B cell differentiation (GO:0045577)2.74684190
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73778985
70regulation of T-helper 2 cell differentiation (GO:0045628)2.73657232
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71628392
72myeloid cell activation involved in immune response (GO:0002275)2.69258338
73detection of biotic stimulus (GO:0009595)2.68295934
74defense response to protozoan (GO:0042832)2.68030384
75JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64123842
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.63018240
77pentose-phosphate shunt (GO:0006098)2.61738991
78negative regulation of interleukin-6 production (GO:0032715)2.60867377
79negative regulation of leukocyte mediated immunity (GO:0002704)2.58661526
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58256905
81negative regulation of lymphocyte mediated immunity (GO:0002707)2.57799784
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57332438
83response to protozoan (GO:0001562)2.56627193
84positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55682070
85regulation of tolerance induction (GO:0002643)2.54653392
86negative regulation of T cell mediated immunity (GO:0002710)2.53356926
87neutrophil mediated immunity (GO:0002446)2.52006261
88cellular response to interleukin-15 (GO:0071350)2.51600859
89antigen processing and presentation via MHC class Ib (GO:0002475)2.51519076
90positive regulation of interferon-alpha production (GO:0032727)2.51485034
91regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51282228
92regulation of natural killer cell mediated immunity (GO:0002715)2.51282228
93regulation of regulated secretory pathway (GO:1903305)2.51031174
94T cell migration (GO:0072678)2.50994342
95megakaryocyte development (GO:0035855)2.49370387
96modulation by symbiont of host cellular process (GO:0044068)2.49350605
97macrophage activation (GO:0042116)2.46309834
98T-helper 1 type immune response (GO:0042088)2.45924509
99negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45157239
100myeloid dendritic cell differentiation (GO:0043011)2.41996697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.04060801
2VDR_21846776_ChIP-Seq_THP-1_Human3.02653579
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.96305810
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.83901958
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72040988
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.70529004
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60884684
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57290042
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.42425884
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25135695
11LXR_22292898_ChIP-Seq_THP-1_Human2.24544896
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.24078537
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.23621253
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21174360
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20767007
16MAF_26560356_Chip-Seq_TH1_Human2.20064552
17VDR_24763502_ChIP-Seq_THP-1_Human2.19993993
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17017083
19TCF7_22412390_ChIP-Seq_EML_Mouse2.15840967
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07543465
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05784214
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04221512
23KDM2B_26808549_Chip-Seq_DND41_Human2.02727749
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00900596
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96813317
26UTX_26944678_Chip-Seq_JUKART_Human1.96197403
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95303404
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95100592
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.94403368
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91347042
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88457634
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88298452
33SPI1_23127762_ChIP-Seq_K562_Human1.82312961
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.80378477
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80238690
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.79708038
37SPI1_23547873_ChIP-Seq_NB4_Human1.79560716
38MAF_26560356_Chip-Seq_TH2_Human1.73174861
39RACK7_27058665_Chip-Seq_MCF-7_Human1.69050334
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66304255
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59633252
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58461943
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53433895
44MYB_26560356_Chip-Seq_TH2_Human1.52616326
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49759250
46MYB_26560356_Chip-Seq_TH1_Human1.49433719
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48598090
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46867362
49SCL_19346495_ChIP-Seq_HPC-7_Human1.46339740
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45999125
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44798322
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44036733
53RUNX_20019798_ChIP-Seq_JUKART_Human1.42557031
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40871154
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.39528240
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.34703786
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34332401
58NCOR1_26117541_ChIP-Seq_K562_Human1.34126341
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33310090
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33087748
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32964204
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29345198
63GATA1_19941826_ChIP-Seq_K562_Human1.27845284
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24961770
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24825393
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23926643
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.23435613
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.23145664
69P68_20966046_ChIP-Seq_HELA_Human1.22807100
70BCL6_27268052_Chip-Seq_Bcells_Human1.21586827
71KDM2B_26808549_Chip-Seq_K562_Human1.19881563
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19283145
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18686817
74BCOR_27268052_Chip-Seq_Bcells_Human1.17739796
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.16894730
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16807597
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16205857
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16004561
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15970202
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13812583
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12689206
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12263105
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12104747
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11468282
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10474328
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10356568
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08199516
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07974198
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07424404
90SMC4_20622854_ChIP-Seq_HELA_Human1.02521690
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01184832
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01091076
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99832943
94ATF3_27146783_Chip-Seq_COLON_Human0.99429812
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99270586
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97660576
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.97205190
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96866436
99GATA3_27048872_Chip-Seq_THYMUS_Human0.95930249
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92860709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.83937203
2MP0003303_peritoneal_inflammation3.47063940
3MP0005451_abnormal_body_composition3.45832676
4MP0001835_abnormal_antigen_presentation2.81078251
5MP0005058_abnormal_lysosome_morphology2.70982668
6MP0003172_abnormal_lysosome_physiology2.63388156
7MP0003724_increased_susceptibility_to2.62966173
8MP0002419_abnormal_innate_immunity2.56843155
9MP0003300_gastrointestinal_ulcer2.47297433
10MP0004947_skin_inflammation2.45543982
11MP0005025_abnormal_response_to2.40503031
12MP0005000_abnormal_immune_tolerance2.40294501
13MP0005671_abnormal_response_to2.36389187
14MP0005387_immune_system_phenotype2.34782891
15MP0001790_abnormal_immune_system2.34782891
16MP0000685_abnormal_immune_system2.33807689
17MP0009785_altered_susceptibility_to2.32739191
18MP0001800_abnormal_humoral_immune2.31827242
19MP0003191_abnormal_cellular_cholesterol2.29674295
20MP0008260_abnormal_autophagy2.27171369
21MP0002723_abnormal_immune_serum2.16837845
22MP0002452_abnormal_antigen_presenting2.16448127
23MP0002420_abnormal_adaptive_immunity2.15397678
24MP0001819_abnormal_immune_cell2.13369908
25MP0003763_abnormal_thymus_physiology2.11447812
26MP0003705_abnormal_hypodermis_morpholog2.10294777
27MP0009278_abnormal_bone_marrow2.02992308
28MP0002148_abnormal_hypersensitivity_rea1.97875957
29MP0000858_altered_metastatic_potential1.86596593
30MP0001533_abnormal_skeleton_physiology1.82973410
31MP0002398_abnormal_bone_marrow1.78332989
32MP0002405_respiratory_system_inflammati1.73834094
33MP0009840_abnormal_foam_cell1.72957370
34MP0005464_abnormal_platelet_physiology1.72553890
35MP0006082_CNS_inflammation1.70830306
36MP0005076_abnormal_cell_differentiation1.67870191
37MP0000716_abnormal_immune_system1.63937671
38MP0010155_abnormal_intestine_physiology1.63490697
39MP0009333_abnormal_splenocyte_physiolog1.60753411
40MP0002877_abnormal_melanocyte_morpholog1.52744620
41MP0003091_abnormal_cell_migration1.52254012
42MP0003828_pulmonary_edema1.52031968
43MP0001845_abnormal_inflammatory_respons1.51922835
44MP0002722_abnormal_immune_system1.49422597
45MP0000689_abnormal_spleen_morphology1.42864134
46MP0002429_abnormal_blood_cell1.39688540
47MP0003453_abnormal_keratinocyte_physiol1.38882610
48MP0003566_abnormal_cell_adhesion1.38201844
49MP0003656_abnormal_erythrocyte_physiolo1.36925937
50MP0002998_abnormal_bone_remodeling1.33107839
51MP0004510_myositis1.32377895
52MP0002396_abnormal_hematopoietic_system1.31296493
53MP0000703_abnormal_thymus_morphology1.30265005
54MP0003866_abnormal_defecation1.29651097
55MP0008469_abnormal_protein_level1.29025019
56MP0009764_decreased_sensitivity_to1.27920903
57MP0003075_altered_response_to1.25147077
58MP0005397_hematopoietic_system_phenotyp1.22748915
59MP0001545_abnormal_hematopoietic_system1.22748915
60MP0000465_gastrointestinal_hemorrhage1.19403206
61MP0005310_abnormal_salivary_gland1.18912769
62MP0001853_heart_inflammation1.16873796
63MP0001849_ear_inflammation1.16766155
64MP0002166_altered_tumor_susceptibility1.16102736
65MP0003448_altered_tumor_morphology1.12569195
66MP0008438_abnormal_cutaneous_collagen1.12217725
67MP0003279_aneurysm1.06631227
68MP0008004_abnormal_stomach_pH1.04607824
69MP0001958_emphysema1.03749376
70MP0000343_altered_response_to1.02005139
71MP0004808_abnormal_hematopoietic_stem0.98229564
72MP0005390_skeleton_phenotype0.96028043
73MP0004381_abnormal_hair_follicle0.95187575
74MP0001851_eye_inflammation0.94149825
75MP0005166_decreased_susceptibility_to0.90475746
76MP0001873_stomach_inflammation0.90274427
77MP0002933_joint_inflammation0.89263532
78MP0003045_fibrosis0.87753314
79MP0009763_increased_sensitivity_to0.87208283
80MP0004185_abnormal_adipocyte_glucose0.87145627
81MP0000604_amyloidosis0.84923337
82MP0002132_abnormal_respiratory_system0.84790599
83MP0003183_abnormal_peptide_metabolism0.83910705
84MP0005164_abnormal_response_to0.81973343
85MP0005023_abnormal_wound_healing0.80911193
86MP0003795_abnormal_bone_structure0.78103777
87MP0002006_tumorigenesis0.78070190
88MP0003221_abnormal_cardiomyocyte_apopto0.76487930
89MP0004883_abnormal_blood_vessel0.74966806
90MP0005621_abnormal_cell_physiology0.74031980
91MP0002060_abnormal_skin_morphology0.71193563
92MP0010234_abnormal_vibrissa_follicle0.71096745
93MP0008874_decreased_physiological_sensi0.69611281
94MP0002332_abnormal_exercise_endurance0.69115917
95MP0000490_abnormal_crypts_of0.68744887
96MP0001663_abnormal_digestive_system0.68032667
97MP0000767_abnormal_smooth_muscle0.67922291
98MP0009931_abnormal_skin_appearance0.67801605
99MP0002019_abnormal_tumor_incidence0.66588065
100MP0001348_abnormal_lacrimal_gland0.65318729

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.00103185
2Abnormality of macrophages (HP:0004311)4.39541608
3Recurrent abscess formation (HP:0002722)3.84569805
4Recurrent bacterial skin infections (HP:0005406)3.80951906
5Recurrent gram-negative bacterial infections (HP:0005420)3.74385213
6Myositis (HP:0100614)3.23900231
7Increased IgM level (HP:0003496)3.12797219
8Cellulitis (HP:0100658)3.11945685
9Orchitis (HP:0100796)3.11218031
10Hemorrhage of the eye (HP:0011885)2.97750137
11Elevated erythrocyte sedimentation rate (HP:0003565)2.89407898
12Recurrent fungal infections (HP:0002841)2.87575777
13Abnormality of glycolipid metabolism (HP:0010969)2.87033977
14Abnormality of liposaccharide metabolism (HP:0010968)2.87033977
15Abnormality of glycosphingolipid metabolism (HP:0004343)2.87033977
16Obstructive lung disease (HP:0006536)2.86808895
17Chronic obstructive pulmonary disease (HP:0006510)2.86808895
18Mediastinal lymphadenopathy (HP:0100721)2.86184848
19Stomatitis (HP:0010280)2.77202158
20Dysostosis multiplex (HP:0000943)2.74080067
21Meningitis (HP:0001287)2.71902720
22Retrobulbar optic neuritis (HP:0100654)2.70717020
23Optic neuritis (HP:0100653)2.70717020
24Broad face (HP:0000283)2.70288236
25Gastrointestinal infarctions (HP:0005244)2.70107337
26Gingivitis (HP:0000230)2.64226602
27Urinary glycosaminoglycan excretion (HP:0003541)2.61575127
28Mucopolysacchariduria (HP:0008155)2.61575127
29Abnormality of polysaccharide metabolism (HP:0011012)2.59755687
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59755687
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59755687
32Increased IgE level (HP:0003212)2.56652245
33Increased cerebral lipofuscin (HP:0011813)2.55251010
34Distal lower limb amyotrophy (HP:0008944)2.52013652
35Recurrent skin infections (HP:0001581)2.50311710
36Increased connective tissue (HP:0009025)2.43102311
37Encephalitis (HP:0002383)2.38917282
38Recurrent viral infections (HP:0004429)2.38865422
39Cervical subluxation (HP:0003308)2.35232327
40Granulocytopenia (HP:0001913)2.33811828
41Loss of speech (HP:0002371)2.30019554
42Vasculitis (HP:0002633)2.29420531
43Vertebral compression fractures (HP:0002953)2.28596592
44Urticaria (HP:0001025)2.26937812
45Pustule (HP:0200039)2.25532276
46Recurrent cutaneous fungal infections (HP:0011370)2.22630190
47Chronic mucocutaneous candidiasis (HP:0002728)2.22630190
48Increased serum ferritin (HP:0003281)2.20830007
49Distal lower limb muscle weakness (HP:0009053)2.20232629
50Vacuolated lymphocytes (HP:0001922)2.19391251
51J-shaped sella turcica (HP:0002680)2.18218724
52Hypergammaglobulinemia (HP:0010702)2.17693627
53Peritonitis (HP:0002586)2.17689258
54Achilles tendon contracture (HP:0001771)2.16517310
55Thick nail (HP:0001805)2.12730557
56Agammaglobulinemia (HP:0004432)2.11004611
57Hepatosplenomegaly (HP:0001433)2.09133430
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.08369452
59Gastrointestinal inflammation (HP:0004386)2.07677128
60Osteomyelitis (HP:0002754)2.05757807
61Prolonged bleeding time (HP:0003010)2.03373758
62Epistaxis (HP:0000421)2.02551246
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.00793003
64Colitis (HP:0002583)2.00099117
65Abnormality of the fingertips (HP:0001211)1.99336766
66Episodic fever (HP:0001954)1.99009315
67Verrucae (HP:0200043)1.97378505
68Papilloma (HP:0012740)1.97378505
69Pulmonary infiltrates (HP:0002113)1.97322320
70Inflammation of the large intestine (HP:0002037)1.96410322
71Autoimmune hemolytic anemia (HP:0001890)1.95961092
72T lymphocytopenia (HP:0005403)1.94390461
73Leukocytosis (HP:0001974)1.93066397
74Spontaneous hematomas (HP:0007420)1.92715969
75Cerebral aneurysm (HP:0004944)1.92268462
76Obstructive sleep apnea (HP:0002870)1.90956129
77Reticulocytosis (HP:0001923)1.90915465
78Chest pain (HP:0100749)1.90901408
79Abnormality of the Achilles tendon (HP:0005109)1.90716115
80Dilatation of the ascending aorta (HP:0005111)1.89530808
81Abnormal delayed hypersensitivity skin test (HP:0002963)1.88488218
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87834070
83Thin bony cortex (HP:0002753)1.87660747
84Keratoconjunctivitis sicca (HP:0001097)1.87317299
85Slow saccadic eye movements (HP:0000514)1.87040591
86Distal upper limb amyotrophy (HP:0007149)1.85610751
87Upper limb amyotrophy (HP:0009129)1.85610751
88Recurrent bronchitis (HP:0002837)1.84804134
89Interstitial pulmonary disease (HP:0006530)1.83024590
90Amyloidosis (HP:0011034)1.82937207
91Premature rupture of membranes (HP:0001788)1.82259733
92Arterial thrombosis (HP:0004420)1.81742921
93Abnormality of the peritoneum (HP:0002585)1.80400823
94Myocardial infarction (HP:0001658)1.80128905
95Sepsis (HP:0100806)1.79408278
96Spondylolisthesis (HP:0003302)1.79390129
97Gastrointestinal stroma tumor (HP:0100723)1.78673634
98Petechiae (HP:0000967)1.75748934
99Hyperacusis (HP:0010780)1.74454571
100Restrictive lung disease (HP:0002091)1.73711655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.37788030
2PRPF4B3.26416690
3MAP4K13.09038945
4TRIB33.07791534
5IRAK32.97518271
6RIPK42.75779640
7MAP2K32.39622939
8IRAK42.38423981
9BLK2.34000547
10MAP3K132.05375697
11TYK22.01513006
12MAP3K142.00880400
13SIK11.97939170
14EPHB11.94111731
15TAOK21.88528758
16SMG11.86736927
17TESK21.82265274
18ZAP701.80435672
19MAP3K31.75595231
20TTN1.72513805
21GRK61.71555102
22TBK11.71063112
23MAP3K111.65940184
24ICK1.65293032
25TAOK11.63861736
26CSK1.53751186
27CDK121.48855857
28JAK31.34545556
29FGFR41.26866828
30ARAF1.24255642
31IKBKE1.23759942
32MAP3K11.20818870
33FES1.17290021
34MST1R1.15573495
35IKBKB1.10635975
36CDC42BPA1.08812503
37IRAK21.07087588
38KDR1.05625790
39BTK1.02461174
40TXK1.02336970
41STK101.01431682
42SIK30.99253785
43SYK0.97001935
44CSF1R0.96317055
45PKN20.95304717
46HCK0.92709067
47FGR0.92097932
48TNK20.90701598
49JAK10.90383345
50NME20.88426995
51RIPK10.88005753
52TESK10.86591054
53PRKD20.85843283
54PTK60.85139324
55KSR20.84435719
56MARK20.79673099
57RPS6KA20.77580802
58PDPK10.77002177
59MATK0.76507267
60MAP2K20.76427754
61SIK20.76246374
62JAK20.74680418
63RPS6KL10.73264364
64RPS6KC10.73264364
65PAK40.72693709
66LYN0.70698487
67LCK0.70490877
68PIM20.70193736
69IRAK10.68170303
70MAP3K80.66541880
71MAPK110.65127218
72EPHA20.63711992
73PDK10.62943724
74EEF2K0.62339846
75CDK40.62214880
76ITK0.62006401
77KIT0.61456867
78LRRK20.61422105
79MOS0.58915191
80MAP3K100.57115081
81BRAF0.55036754
82CHUK0.54772934
83HIPK20.53842278
84MAP3K60.52675139
85RPS6KA60.52332263
86MAPK120.51108614
87MAPKAPK20.48829244
88PDGFRA0.47331650
89CLK10.46592586
90BMPR20.43864358
91MARK30.43650882
92MTOR0.43538975
93LMTK20.42722462
94CDK60.41946081
95FYN0.40927703
96BMX0.38153884
97MAP3K70.37805505
98MAPK70.37802993
99YES10.37591808
100DDR20.37172154

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.63941534
2Osteoclast differentiation_Homo sapiens_hsa043802.60797397
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46931219
4Leishmaniasis_Homo sapiens_hsa051402.39893928
5B cell receptor signaling pathway_Homo sapiens_hsa046622.31324959
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20248094
7Acute myeloid leukemia_Homo sapiens_hsa052212.08336987
8Primary immunodeficiency_Homo sapiens_hsa053402.07497079
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.98108693
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.85131140
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83611238
12Malaria_Homo sapiens_hsa051441.76203446
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76163200
14Tuberculosis_Homo sapiens_hsa051521.73181161
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71585364
16TNF signaling pathway_Homo sapiens_hsa046681.69895679
17Shigellosis_Homo sapiens_hsa051311.67641686
18Chronic myeloid leukemia_Homo sapiens_hsa052201.66799710
19T cell receptor signaling pathway_Homo sapiens_hsa046601.66511050
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64914292
21Measles_Homo sapiens_hsa051621.61138905
22Staphylococcus aureus infection_Homo sapiens_hsa051501.55577942
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53379140
24Toxoplasmosis_Homo sapiens_hsa051451.52696994
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48990731
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45451782
27Influenza A_Homo sapiens_hsa051641.42595939
28Hematopoietic cell lineage_Homo sapiens_hsa046401.41675521
29Allograft rejection_Homo sapiens_hsa053301.39213310
30Graft-versus-host disease_Homo sapiens_hsa053321.36642962
31Non-small cell lung cancer_Homo sapiens_hsa052231.35818341
32Pancreatic cancer_Homo sapiens_hsa052121.35790095
33Hepatitis B_Homo sapiens_hsa051611.35234753
34Lysosome_Homo sapiens_hsa041421.34654927
35Herpes simplex infection_Homo sapiens_hsa051681.30976902
36Antigen processing and presentation_Homo sapiens_hsa046121.29403411
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27678254
38Salmonella infection_Homo sapiens_hsa051321.26882762
39Legionellosis_Homo sapiens_hsa051341.23319880
40Hepatitis C_Homo sapiens_hsa051601.22845413
41Autoimmune thyroid disease_Homo sapiens_hsa053201.21858678
42Apoptosis_Homo sapiens_hsa042101.19648097
43Chemokine signaling pathway_Homo sapiens_hsa040621.19208819
44VEGF signaling pathway_Homo sapiens_hsa043701.16821150
45Notch signaling pathway_Homo sapiens_hsa043301.13151954
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.12837317
47Pertussis_Homo sapiens_hsa051331.09193470
48Viral myocarditis_Homo sapiens_hsa054161.08223669
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06406150
50Bladder cancer_Homo sapiens_hsa052191.06009279
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05532006
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03803642
53Rheumatoid arthritis_Homo sapiens_hsa053231.03433938
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.03326192
55Phagosome_Homo sapiens_hsa041451.01028123
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.00352945
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00347258
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.99096130
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94304058
60Renal cell carcinoma_Homo sapiens_hsa052110.93254163
61African trypanosomiasis_Homo sapiens_hsa051430.91682609
62Amoebiasis_Homo sapiens_hsa051460.89884110
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.89881912
64Prolactin signaling pathway_Homo sapiens_hsa049170.89802483
65Epstein-Barr virus infection_Homo sapiens_hsa051690.88099084
66Pentose phosphate pathway_Homo sapiens_hsa000300.87319502
67HTLV-I infection_Homo sapiens_hsa051660.85129108
68Platelet activation_Homo sapiens_hsa046110.82382429
69Endocytosis_Homo sapiens_hsa041440.82201045
70Viral carcinogenesis_Homo sapiens_hsa052030.81506980
71Fructose and mannose metabolism_Homo sapiens_hsa000510.80641436
72Type I diabetes mellitus_Homo sapiens_hsa049400.79091564
73Prion diseases_Homo sapiens_hsa050200.78732062
74Galactose metabolism_Homo sapiens_hsa000520.76965881
75Endometrial cancer_Homo sapiens_hsa052130.73931922
76mTOR signaling pathway_Homo sapiens_hsa041500.69592681
77Small cell lung cancer_Homo sapiens_hsa052220.66233614
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.65742639
79Thyroid cancer_Homo sapiens_hsa052160.64520989
80GnRH signaling pathway_Homo sapiens_hsa049120.62752252
81Prostate cancer_Homo sapiens_hsa052150.60805177
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60698641
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.60359490
84Insulin signaling pathway_Homo sapiens_hsa049100.59593724
85ErbB signaling pathway_Homo sapiens_hsa040120.59559807
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59112382
87Insulin resistance_Homo sapiens_hsa049310.58852851
88HIF-1 signaling pathway_Homo sapiens_hsa040660.58496005
89Asthma_Homo sapiens_hsa053100.53322104
90Proteoglycans in cancer_Homo sapiens_hsa052050.52626902
91Glioma_Homo sapiens_hsa052140.52494405
92Focal adhesion_Homo sapiens_hsa045100.51595280
93Choline metabolism in cancer_Homo sapiens_hsa052310.50302857
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48410256
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47992205
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47686890
97FoxO signaling pathway_Homo sapiens_hsa040680.44984538
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43860681
99Estrogen signaling pathway_Homo sapiens_hsa049150.43607752
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43580449

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