IKZF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.87782852
2regulation of gamma-delta T cell differentiation (GO:0045586)6.52583698
3B cell receptor signaling pathway (GO:0050853)6.37751301
4positive thymic T cell selection (GO:0045059)6.35796335
5negative T cell selection (GO:0043383)6.24328518
6negative thymic T cell selection (GO:0045060)6.09955557
7antigen processing and presentation of endogenous antigen (GO:0019883)5.92468275
8regulation of gamma-delta T cell activation (GO:0046643)5.92409288
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.88859298
10negative regulation of cell killing (GO:0031342)5.88859298
11regulation of B cell receptor signaling pathway (GO:0050855)5.80084227
12positive T cell selection (GO:0043368)5.65394354
13response to interleukin-15 (GO:0070672)5.48219303
14thymic T cell selection (GO:0045061)5.47750347
15cellular response to interleukin-15 (GO:0071350)5.43602722
16T cell selection (GO:0045058)5.40838146
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.31721197
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31721197
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.08633912
20interferon-gamma production (GO:0032609)4.93488795
21antigen receptor-mediated signaling pathway (GO:0050851)4.58837844
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.58080421
23regulation of T cell tolerance induction (GO:0002664)4.55491952
24tolerance induction (GO:0002507)4.53930822
25T cell costimulation (GO:0031295)4.42212252
26T cell migration (GO:0072678)4.40641003
27lymphocyte costimulation (GO:0031294)4.38208076
28regulation of isotype switching to IgG isotypes (GO:0048302)4.37997786
29positive regulation of B cell differentiation (GO:0045579)4.28933675
30regulation of alpha-beta T cell proliferation (GO:0046640)4.26933619
31B cell proliferation (GO:0042100)4.18275493
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.16241128
33* regulation of B cell differentiation (GO:0045577)4.15432872
34T cell receptor signaling pathway (GO:0050852)4.10870389
35leukocyte aggregation (GO:0070486)4.08319370
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.05403870
37CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.04929510
38regulation of regulatory T cell differentiation (GO:0045589)4.03434797
39positive regulation of interleukin-2 production (GO:0032743)4.01730419
40negative regulation of B cell proliferation (GO:0030889)3.98479753
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.90459318
42activated T cell proliferation (GO:0050798)3.81646419
43positive regulation of immunoglobulin production (GO:0002639)3.80564889
44cellular response to zinc ion (GO:0071294)3.74431260
45* regulation of B cell proliferation (GO:0030888)3.72344307
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71454475
47positive regulation of tolerance induction (GO:0002645)3.70208685
48cytidine metabolic process (GO:0046087)3.69279618
49cytidine catabolic process (GO:0006216)3.69279618
50cytidine deamination (GO:0009972)3.69279618
51mature B cell differentiation (GO:0002335)3.65526210
52regulation of T cell mediated cytotoxicity (GO:0001914)3.63397384
53positive regulation of isotype switching (GO:0045830)3.63349944
54response to type I interferon (GO:0034340)3.63253136
55negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.62170034
56immune response-activating cell surface receptor signaling pathway (GO:0002429)3.60627825
57cellular response to type I interferon (GO:0071357)3.57814685
58type I interferon signaling pathway (GO:0060337)3.57814685
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.56929835
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.56211236
61pyrimidine ribonucleoside catabolic process (GO:0046133)3.56039179
62positive regulation of B cell proliferation (GO:0030890)3.55087743
63regulation of T cell receptor signaling pathway (GO:0050856)3.49685693
64T cell homeostasis (GO:0043029)3.48949361
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48382483
66regulation of immunoglobulin production (GO:0002637)3.44915129
67lymphocyte homeostasis (GO:0002260)3.44588212
68positive regulation of humoral immune response (GO:0002922)3.43460798
69regulation of isotype switching (GO:0045191)3.40671001
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.37580395
71modulation by symbiont of host immune response (GO:0052553)3.37580395
72positive regulation by symbiont of host defense response (GO:0052509)3.37580395
73modulation by symbiont of host defense response (GO:0052031)3.37580395
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37580395
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37580395
76regulation of tolerance induction (GO:0002643)3.36558458
77positive regulation of B cell activation (GO:0050871)3.33200290
78interferon-gamma-mediated signaling pathway (GO:0060333)3.29451832
79regulation of leukocyte mediated cytotoxicity (GO:0001910)3.29000399
80regulation of interleukin-2 biosynthetic process (GO:0045076)3.27911277
81positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.27387618
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27359216
83negative regulation of leukocyte mediated immunity (GO:0002704)3.25798492
84antigen processing and presentation via MHC class Ib (GO:0002475)3.21987595
85immunoglobulin mediated immune response (GO:0016064)3.20622639
86positive regulation of cell killing (GO:0031343)3.20323059
87B cell homeostasis (GO:0001782)3.19344197
88regulation of cell killing (GO:0031341)3.19203722
89regulation of chronic inflammatory response (GO:0002676)3.17402498
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15863438
91regulation of interferon-beta biosynthetic process (GO:0045357)3.14840207
92positive regulation of DNA recombination (GO:0045911)3.14113183
93macrophage activation involved in immune response (GO:0002281)3.12353517
94lymphocyte proliferation (GO:0046651)3.11336866
95V(D)J recombination (GO:0033151)3.10649600
96DNA deamination (GO:0045006)3.10229712
97mononuclear cell proliferation (GO:0032943)3.10013432
98positive regulation of histone deacetylation (GO:0031065)3.09125155
99Peyers patch development (GO:0048541)3.09091417
100mucosal-associated lymphoid tissue development (GO:0048537)3.09091417
101detection of bacterium (GO:0016045)3.08921750
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08310416
103T cell proliferation (GO:0042098)3.07533310
104leukocyte cell-cell adhesion (GO:0007159)3.06289797
105mast cell activation (GO:0045576)3.06275022
106positive regulation of defense response to virus by host (GO:0002230)3.05060326
107* regulation of B cell activation (GO:0050864)3.04415589
108positive regulation of natural killer cell mediated immunity (GO:0002717)3.03591819
109response to protozoan (GO:0001562)3.02683925
110negative regulation of T cell receptor signaling pathway (GO:0050860)3.00864233
111regulation of alpha-beta T cell activation (GO:0046634)2.99586666
112negative regulation of T cell mediated immunity (GO:0002710)2.97760069
113regulation of B cell mediated immunity (GO:0002712)2.96753049
114positive regulation of T cell cytokine production (GO:0002726)2.96197908
115detection of other organism (GO:0098543)2.95283491
116cellular extravasation (GO:0045123)2.93178234
117negative regulation of adaptive immune response (GO:0002820)2.92447050
118regulation of immunoglobulin mediated immune response (GO:0002889)2.91792930
119natural killer cell activation (GO:0030101)2.90724851
120regulation of interleukin-2 production (GO:0032663)2.90205574
121leukocyte homeostasis (GO:0001776)2.90101930
122regulation of B cell apoptotic process (GO:0002902)2.88668549
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.86618713
124hepatocyte apoptotic process (GO:0097284)2.84940196
125positive regulation of T cell differentiation (GO:0045582)2.83205867
126T cell differentiation (GO:0030217)2.83166567
127positive regulation of T cell activation (GO:0050870)2.83047629
128NIK/NF-kappaB signaling (GO:0038061)2.81806735
129leukocyte proliferation (GO:0070661)2.81700632
130negative regulation of phagocytosis (GO:0050765)2.81375726
131positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80224699
132positive regulation of B cell mediated immunity (GO:0002714)2.80224699
133negative regulation of lymphocyte mediated immunity (GO:0002707)2.77783847
134positive regulation of Rap GTPase activity (GO:0032854)2.77610681
135positive regulation of granulocyte differentiation (GO:0030854)2.77525626
136* B cell activation (GO:0042113)2.77031109
137defense response to protozoan (GO:0042832)2.77020607
138lymph node development (GO:0048535)2.76296453
139negative regulation of histone methylation (GO:0031061)2.75518974
140myeloid dendritic cell activation (GO:0001773)2.74675763
141regulation of natural killer cell mediated immunity (GO:0002715)2.73809501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.87233194
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.02743227
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.93752076
4E2F7_22180533_ChIP-Seq_HELA_Human4.80702927
5MYC_22102868_ChIP-Seq_BL_Human4.63497295
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.08950932
7RUNX_20019798_ChIP-Seq_JUKART_Human3.51181718
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.36350808
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.30454706
10MYB_26560356_Chip-Seq_TH2_Human3.16508412
11* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10970736
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07223919
13VDR_21846776_ChIP-Seq_THP-1_Human2.91686397
14MAF_26560356_Chip-Seq_TH1_Human2.90913120
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.90762473
16MYB_26560356_Chip-Seq_TH1_Human2.83193813
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74246260
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.64490487
19UTX_26944678_Chip-Seq_JUKART_Human2.63181796
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.58964368
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57660734
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.32265677
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27491336
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.19101151
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.17748284
26TCF7_22412390_ChIP-Seq_EML_Mouse2.15044399
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05352806
28CIITA_25753668_ChIP-Seq_RAJI_Human2.01249283
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00259670
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98300706
31VDR_24763502_ChIP-Seq_THP-1_Human1.93451864
32MAF_26560356_Chip-Seq_TH2_Human1.90624943
33GATA3_27048872_Chip-Seq_THYMUS_Human1.90344553
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89693490
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87375458
36* SPI1_23547873_ChIP-Seq_NB4_Human1.86536106
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86011344
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.85216199
39KDM2B_26808549_Chip-Seq_DND41_Human1.81545169
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81124347
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.79447552
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75802717
43SCL_19346495_ChIP-Seq_HPC-7_Human1.73362143
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66439796
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65034920
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64664040
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62955491
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59829201
49SPI1_23127762_ChIP-Seq_K562_Human1.53544787
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45562624
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43983500
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43153323
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35642425
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33334402
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32773304
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32391105
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32228608
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30574067
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29220025
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.24335544
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22487553
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21325692
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17090943
64* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17068156
65FOXP3_21729870_ChIP-Seq_TREG_Human1.16952360
66SMRT_27268052_Chip-Seq_Bcells_Human1.16934069
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.16074943
68* PU_27001747_Chip-Seq_BMDM_Mouse1.13252981
69GATA3_26560356_Chip-Seq_TH2_Human1.12314973
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11970796
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07400468
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.07321176
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.06665970
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06520045
75VDR_23849224_ChIP-Seq_CD4+_Human1.06479809
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04760443
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04299310
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.00132881
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98841721
80NCOR1_26117541_ChIP-Seq_K562_Human0.96465143
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96382711
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93783709
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93647683
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92995637
85KDM5A_27292631_Chip-Seq_BREAST_Human0.92776200
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92372722
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92022283
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91391520
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90205269
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90076970
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89516306
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87519583
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86963355
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86422639
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.82491434
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82127304
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.81410142
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80597967
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.80513322
100IRF1_19129219_ChIP-ChIP_H3396_Human0.80202845
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79011036
102GATA1_22025678_ChIP-Seq_K562_Human0.78898526
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75486683
104GATA3_26560356_Chip-Seq_TH1_Human0.75043681
105BCL6_27268052_Chip-Seq_Bcells_Human0.75035007
106* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74734795
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.74714888
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74361914
109* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73394149
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73087285
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71066912
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70583120
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70172250
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69472151
115AR_21572438_ChIP-Seq_LNCaP_Human0.69287082
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.68353962
117ZNF274_21170338_ChIP-Seq_K562_Hela0.68143517
118P300_27268052_Chip-Seq_Bcells_Human0.68129361
119SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.67800990
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67657856
121* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67183477
122TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.67167768
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67099625
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.67003338
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.66634031
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64908847
127VDR_24787735_ChIP-Seq_THP-1_Human0.64019798
128GATA1_19941826_ChIP-Seq_K562_Human0.63897472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.42442698
2MP0001835_abnormal_antigen_presentation4.38242272
3* MP0001800_abnormal_humoral_immune4.33187637
4MP0005387_immune_system_phenotype4.16176946
5MP0001790_abnormal_immune_system4.16176946
6MP0003763_abnormal_thymus_physiology4.15215260
7MP0000685_abnormal_immune_system3.50864072
8* MP0002452_abnormal_antigen_presenting3.22481624
9MP0003303_peritoneal_inflammation3.15571715
10* MP0002723_abnormal_immune_serum3.05055562
11* MP0005000_abnormal_immune_tolerance3.02059614
12* MP0002420_abnormal_adaptive_immunity3.01888901
13* MP0002398_abnormal_bone_marrow3.01242798
14* MP0001819_abnormal_immune_cell2.94613363
15MP0001873_stomach_inflammation2.74452724
16MP0003300_gastrointestinal_ulcer2.70720997
17MP0002166_altered_tumor_susceptibility2.66465389
18* MP0000716_abnormal_immune_system2.66145600
19* MP0000689_abnormal_spleen_morphology2.48219601
20MP0000703_abnormal_thymus_morphology2.38685101
21* MP0002722_abnormal_immune_system2.35155075
22MP0005025_abnormal_response_to2.23849601
23MP0002405_respiratory_system_inflammati2.19332182
24* MP0002429_abnormal_blood_cell2.15872217
25MP0009785_altered_susceptibility_to2.13203786
26MP0002006_tumorigenesis2.13147527
27MP0002396_abnormal_hematopoietic_system2.10693741
28MP0010155_abnormal_intestine_physiology1.98148632
29MP0009333_abnormal_splenocyte_physiolog1.96190405
30MP0003436_decreased_susceptibility_to1.94838368
31MP0004947_skin_inflammation1.86584748
32MP0003866_abnormal_defecation1.80665509
33MP0006082_CNS_inflammation1.75435062
34MP0002933_joint_inflammation1.74355927
35MP0001853_heart_inflammation1.69995493
36MP0002419_abnormal_innate_immunity1.69457253
37* MP0001845_abnormal_inflammatory_respons1.66452513
38MP0004808_abnormal_hematopoietic_stem1.66033703
39MP0005310_abnormal_salivary_gland1.64520420
40MP0008057_abnormal_DNA_replication1.58279889
41* MP0002148_abnormal_hypersensitivity_rea1.51232777
42MP0004510_myositis1.49457779
43MP0005464_abnormal_platelet_physiology1.33025237
44MP0010352_gastrointestinal_tract_polyps1.27926156
45MP0000465_gastrointestinal_hemorrhage1.25333668
46MP0000490_abnormal_crypts_of1.18765864
47MP0002009_preneoplasia1.15060779
48MP0001986_abnormal_taste_sensitivity1.14476164
49* MP0002019_abnormal_tumor_incidence1.13359954
50MP0008961_abnormal_basal_metabolism1.12810393
51MP0002163_abnormal_gland_morphology1.12573647
52MP0005645_abnormal_hypothalamus_physiol1.09104396
53MP0010094_abnormal_chromosome_stability1.07656899
54MP0003077_abnormal_cell_cycle0.98411222
55MP0009764_decreased_sensitivity_to0.96740027
56MP0000858_altered_metastatic_potential0.96030997
57MP0008877_abnormal_DNA_methylation0.95886650
58MP0003448_altered_tumor_morphology0.95045727
59MP0005174_abnormal_tail_pigmentation0.94669624
60MP0008469_abnormal_protein_level0.91249025
61MP0005076_abnormal_cell_differentiation0.88621388
62MP0002277_abnormal_respiratory_mucosa0.85985816
63MP0001348_abnormal_lacrimal_gland0.85932671
64MP0002132_abnormal_respiratory_system0.84720354
65MP0003045_fibrosis0.84577217
66MP0003724_increased_susceptibility_to0.84165901
67MP0006054_spinal_hemorrhage0.83840774
68MP0003787_abnormal_imprinting0.78637272
69MP0000569_abnormal_digit_pigmentation0.78382843
70MP0003183_abnormal_peptide_metabolism0.77729245
71MP0004883_abnormal_blood_vessel0.77591550
72MP0001545_abnormal_hematopoietic_system0.77547601
73MP0005397_hematopoietic_system_phenotyp0.77547601
74MP0003252_abnormal_bile_duct0.76607534
75MP0001533_abnormal_skeleton_physiology0.76283465
76MP0000015_abnormal_ear_pigmentation0.74882110
77MP0003646_muscle_fatigue0.74864272
78MP0003693_abnormal_embryo_hatching0.74180204
79MP0003172_abnormal_lysosome_physiology0.73532976
80MP0003091_abnormal_cell_migration0.72848823
81* MP0002136_abnormal_kidney_physiology0.72210098
82MP0009278_abnormal_bone_marrow0.70779655
83MP0010234_abnormal_vibrissa_follicle0.67708424
84MP0001663_abnormal_digestive_system0.67682015
85MP0000372_irregular_coat_pigmentation0.65091675
86MP0000371_diluted_coat_color0.65086753
87MP0005075_abnormal_melanosome_morpholog0.62574194
88MP0005379_endocrine/exocrine_gland_phen0.62135772
89MP0000350_abnormal_cell_proliferation0.61131850
90MP0002998_abnormal_bone_remodeling0.61009369
91MP0004957_abnormal_blastocyst_morpholog0.60272255
92MP0005023_abnormal_wound_healing0.59803088
93MP0004130_abnormal_muscle_cell0.59174949
94MP0008872_abnormal_physiological_respon0.57692334
95MP0002095_abnormal_skin_pigmentation0.57195426
96MP0000477_abnormal_intestine_morphology0.56341030
97MP0003111_abnormal_nucleus_morphology0.54128809
98MP0000249_abnormal_blood_vessel0.53679451
99MP0001851_eye_inflammation0.53559211
100MP0003566_abnormal_cell_adhesion0.53344124
101MP0000313_abnormal_cell_death0.52595146
102MP0004142_abnormal_muscle_tone0.51631151
103MP0002138_abnormal_hepatobiliary_system0.51430615
104MP0008260_abnormal_autophagy0.51145969
105MP0008058_abnormal_DNA_repair0.49885459
106MP0000609_abnormal_liver_physiology0.49808906
107MP0003453_abnormal_keratinocyte_physiol0.49315197
108MP0009763_increased_sensitivity_to0.48979194
109MP0010307_abnormal_tumor_latency0.48177504
110MP0005621_abnormal_cell_physiology0.47806968
111MP0002653_abnormal_ependyma_morphology0.47402528
112MP0002928_abnormal_bile_duct0.47257728
113MP0001501_abnormal_sleep_pattern0.46918363
114MP0001919_abnormal_reproductive_system0.46338788
115MP0009765_abnormal_xenobiotic_induced0.46202129
116MP0005381_digestive/alimentary_phenotyp0.45651033
117MP0008874_decreased_physiological_sensi0.44962428
118MP0002693_abnormal_pancreas_physiology0.44632474
119MP0001730_embryonic_growth_arrest0.44226253
120MP0001765_abnormal_ion_homeostasis0.42643836
121MP0001879_abnormal_lymphatic_vessel0.42402260
122MP0004381_abnormal_hair_follicle0.41568633
123MP0005451_abnormal_body_composition0.41061152
124MP0005166_decreased_susceptibility_to0.40036414
125MP0009115_abnormal_fat_cell0.39694851
126MP0000470_abnormal_stomach_morphology0.38864675

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.65256252
2Recurrent bronchitis (HP:0002837)5.76025137
3T lymphocytopenia (HP:0005403)5.57013229
4Abnormality of T cell number (HP:0011839)5.31889711
5Gastrointestinal stroma tumor (HP:0100723)5.28962515
6IgM deficiency (HP:0002850)5.22552627
7Panhypogammaglobulinemia (HP:0003139)5.14810628
8Recurrent sinusitis (HP:0011108)5.07573645
9Recurrent viral infections (HP:0004429)5.04297821
10B lymphocytopenia (HP:0010976)4.98718978
11Abnormality of B cell number (HP:0010975)4.98718978
12Meningitis (HP:0001287)4.55503019
13Papilloma (HP:0012740)4.55186472
14Verrucae (HP:0200043)4.55186472
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.34577529
16Colitis (HP:0002583)4.33851999
17Lymphopenia (HP:0001888)4.27664297
18Abnormality of T cells (HP:0002843)4.26647060
19Inflammation of the large intestine (HP:0002037)4.22489278
20Cellulitis (HP:0100658)4.19907354
21Thyroiditis (HP:0100646)4.15176425
22Gastrointestinal inflammation (HP:0004386)4.08277745
23Abnormality of cells of the lymphoid lineage (HP:0012140)4.07846915
24Vasculitis (HP:0002633)4.04228216
25IgG deficiency (HP:0004315)4.01997122
26Recurrent fungal infections (HP:0002841)3.99733323
27Severe combined immunodeficiency (HP:0004430)3.94093056
28Combined immunodeficiency (HP:0005387)3.87263792
29Abnormality of the fingertips (HP:0001211)3.71908113
30IgA deficiency (HP:0002720)3.71389344
31Chronic otitis media (HP:0000389)3.57315619
32Optic neuritis (HP:0100653)3.50684685
33Retrobulbar optic neuritis (HP:0100654)3.50684685
34Emphysema (HP:0002097)3.46948512
35Myositis (HP:0100614)3.45336588
36Chronic sinusitis (HP:0011109)3.36518269
37Chronic mucocutaneous candidiasis (HP:0002728)3.36396252
38Recurrent cutaneous fungal infections (HP:0011370)3.36396252
39Gastrointestinal infarctions (HP:0005244)3.34635144
40Bronchitis (HP:0012387)3.26083889
41Recurrent otitis media (HP:0000403)3.21631804
42Encephalitis (HP:0002383)3.16321413
43Nasal polyposis (HP:0100582)3.15399815
44Abnormality of T cell physiology (HP:0011840)3.14975430
45Pulmonary infiltrates (HP:0002113)3.03880507
46Restrictive lung disease (HP:0002091)3.00885917
47Increased IgM level (HP:0003496)2.98701788
48Orchitis (HP:0100796)2.94318201
49Lymphoma (HP:0002665)2.89228267
50Autoimmune thrombocytopenia (HP:0001973)2.83308022
51Eosinophilia (HP:0001880)2.78058078
52Pustule (HP:0200039)2.74708078
53Recurrent lower respiratory tract infections (HP:0002783)2.70013106
54Chronic diarrhea (HP:0002028)2.69725650
55Abnormality of macrophages (HP:0004311)2.68720393
56Recurrent pneumonia (HP:0006532)2.68322028
57Mediastinal lymphadenopathy (HP:0100721)2.65973262
58Eczematoid dermatitis (HP:0000976)2.65252381
59Small epiphyses (HP:0010585)2.63591341
60Abnormality of eosinophils (HP:0001879)2.62587415
61Osteomyelitis (HP:0002754)2.62504031
62Obstructive lung disease (HP:0006536)2.58836357
63Chronic obstructive pulmonary disease (HP:0006510)2.58836357
64Keratoconjunctivitis sicca (HP:0001097)2.53449080
65Recurrent abscess formation (HP:0002722)2.52132083
66Sepsis (HP:0100806)2.50893857
67Abnormality of the nasal mucosa (HP:0000433)2.50384398
68Hypoplasia of the thymus (HP:0000778)2.47789872
69Vertebral arch anomaly (HP:0008438)2.46496260
70Arterial thrombosis (HP:0004420)2.45673051
71Elevated erythrocyte sedimentation rate (HP:0003565)2.39785956
72Stomach cancer (HP:0012126)2.38493843
73Granulocytopenia (HP:0001913)2.38130641
74Increased IgE level (HP:0003212)2.36184663
75Hemoptysis (HP:0002105)2.34521874
76Recurrent skin infections (HP:0001581)2.33942943
77Spontaneous hematomas (HP:0007420)2.28327220
78Keratoconjunctivitis (HP:0001096)2.28259187
79Stomatitis (HP:0010280)2.27220907
80Hypochromic anemia (HP:0001931)2.25517483
81Leukopenia (HP:0001882)2.25411424
82Papilledema (HP:0001085)2.24842719
83Mitral stenosis (HP:0001718)2.23357054
84Recurrent bacterial skin infections (HP:0005406)2.23298037
85Chest pain (HP:0100749)2.21895219
86Basal cell carcinoma (HP:0002671)2.20602300
87Leukocytosis (HP:0001974)2.18265798
88Abnormality of the pleura (HP:0002103)2.15789980
89Pulmonary embolism (HP:0002204)2.14481977
90Acute hepatic failure (HP:0006554)2.12464965
91Recurrent gram-negative bacterial infections (HP:0005420)2.08574784
92Urticaria (HP:0001025)2.04041523
93Viral hepatitis (HP:0006562)2.03492550
94Skin rash (HP:0000988)2.01101609
95Alveolar cell carcinoma (HP:0006519)2.00443636
96Skin ulcer (HP:0200042)2.00234784
97Ureteral stenosis (HP:0000071)1.99024954
98Neoplasm of the tracheobronchial system (HP:0100552)1.97582514
99Arthralgia (HP:0002829)1.97207803
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96743792
101Thrombocytosis (HP:0001894)1.95319862
102Hypoproteinemia (HP:0003075)1.93947848
103Abnormality of the prostate (HP:0008775)1.90705211
104Anorexia (HP:0002039)1.89277190
105Hypergammaglobulinemia (HP:0010702)1.88904613
106Gangrene (HP:0100758)1.88713355
107Aplasia/Hypoplasia of the thymus (HP:0010515)1.83565599
108Joint swelling (HP:0001386)1.82040573
109Abnormality of the intervertebral disk (HP:0005108)1.81661579
110Fatigue (HP:0012378)1.80084485
111Ureteral obstruction (HP:0006000)1.78947722
112Flattened epiphyses (HP:0003071)1.77382043
113Volvulus (HP:0002580)1.76644857
114Prolonged bleeding time (HP:0003010)1.74075392
115Increased density of long bones (HP:0006392)1.72940772
116Neutropenia (HP:0001875)1.72355716
117Autoimmune hemolytic anemia (HP:0001890)1.72044822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.78727457
2TXK4.78585282
3GRK63.21938641
4MAP3K103.12331132
5STK102.72725266
6ITK2.48048683
7SYK2.35433047
8JAK32.31200163
9ZAP702.08082598
10JAK12.05555467
11BTK2.04521518
12CDK122.00146592
13FRK1.99071927
14ERN11.98614980
15PRPF4B1.98393093
16BLK1.95735608
17TYK21.93679404
18CSF1R1.77424246
19MAP3K141.76335465
20LRRK21.74295161
21SIK21.73302438
22BMPR21.72743046
23EEF2K1.67733315
24CSK1.62202535
25FGFR41.54866760
26FGFR31.53882498
27MAP3K131.53731122
28LCK1.53074734
29MST41.48001053
30HCK1.44465437
31PRKCQ1.36451942
32TEC1.30477827
33PRKCH1.28138828
34IKBKE1.27660537
35MARK31.27461582
36PIK3CG1.26694309
37PASK1.25218627
38CAMKK21.23797278
39RIPK41.20415324
40LYN1.17516372
41NLK1.11047910
42PIM11.08987217
43TBK11.08394158
44TLK11.06422423
45IKBKB1.05658234
46TGFBR21.05149443
47SIK31.05063459
48CLK11.03435542
49BRD40.95123983
50FES0.93330483
51TNK20.92237227
52CAMKK10.92067845
53CDK40.90894144
54IRAK40.89141866
55TRIB30.88309780
56IRAK30.85135371
57KIT0.82826130
58CDK90.82825935
59MAP3K70.79911838
60CHUK0.77830395
61IRAK10.77163145
62ACVR1B0.76791218
63ALK0.76548586
64HIPK20.75732668
65NEK20.75210126
66ADRBK20.74881499
67FGR0.74473845
68RPS6KA40.74068377
69MELK0.74033458
70MAPK70.70413335
71PRKD20.66717346
72PKN20.65159610
73SGK20.64263491
74MAP2K30.64243213
75JAK20.63392341
76TRPM70.63118447
77STK40.61406199
78TESK20.59942224
79EPHB10.56070750
80PDK10.56017034
81MAP2K60.55471469
82NUAK10.53191037
83SIK10.51648679
84EIF2AK30.49819950
85INSR0.48963488
86TAOK30.47692272
87FYN0.46659917
88STK240.45687116
89CDK60.44954976
90MAP2K20.44359900
91CAMK1G0.44072339
92MAPK120.43717765
93PTK2B0.42391942
94MARK20.41575668
95PDGFRB0.41293333
96EPHA30.38210389
97CDC70.36624806
98ABL10.36478586
99GRK50.35907485
100KDR0.34862089
101CAMK40.34842358
102MAP3K110.34295536
103CHEK10.34148680
104CDC42BPA0.33782878
105MAPK110.33557400
106PRKCI0.33497293
107MATK0.32188188
108CSNK1A1L0.31770101
109MAP3K80.31455117
110PRKD10.31286853
111SGK30.31181042
112PDPK10.30504708
113MAPK40.30305341
114DMPK0.30199917
115GRK70.30194251
116YES10.29791199
117SMG10.29421200
118TAOK10.28913420
119MAPKAPK30.28614835
120WNK10.28200756
121CDK190.27965926
122CSNK1D0.27920630
123GRK10.27720927
124NEK90.27076355
125MAP3K10.27053221
126BMPR1B0.26952295
127FGFR20.26688593
128OXSR10.26563158
129STK110.26519008
130CAMK1D0.26164743
131ATR0.25639115
132PTK60.25298000
133RPS6KA50.24331575

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.35590097
2B cell receptor signaling pathway_Homo sapiens_hsa046623.95234868
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.44109593
4T cell receptor signaling pathway_Homo sapiens_hsa046603.19019126
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.63647187
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.62552675
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60435438
8Hematopoietic cell lineage_Homo sapiens_hsa046402.52595382
9Antigen processing and presentation_Homo sapiens_hsa046122.47519414
10Allograft rejection_Homo sapiens_hsa053302.18936638
11Measles_Homo sapiens_hsa051622.06772171
12Osteoclast differentiation_Homo sapiens_hsa043801.96111900
13Autoimmune thyroid disease_Homo sapiens_hsa053201.95614695
14Graft-versus-host disease_Homo sapiens_hsa053321.92505953
15Leishmaniasis_Homo sapiens_hsa051401.85930744
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72198722
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63474799
18Non-homologous end-joining_Homo sapiens_hsa034501.61283243
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.49604238
20Chemokine signaling pathway_Homo sapiens_hsa040621.40095923
21Herpes simplex infection_Homo sapiens_hsa051681.38556295
22Viral myocarditis_Homo sapiens_hsa054161.32675006
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.28610091
24Asthma_Homo sapiens_hsa053101.23947334
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20877783
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17435963
27Acute myeloid leukemia_Homo sapiens_hsa052211.16643093
28Hepatitis B_Homo sapiens_hsa051611.16103570
29Toxoplasmosis_Homo sapiens_hsa051451.15308190
30Chronic myeloid leukemia_Homo sapiens_hsa052201.14094308
31Epstein-Barr virus infection_Homo sapiens_hsa051691.13920795
32Pancreatic cancer_Homo sapiens_hsa052121.06844623
33HTLV-I infection_Homo sapiens_hsa051661.06000787
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05196165
35Base excision repair_Homo sapiens_hsa034101.00852134
36Non-small cell lung cancer_Homo sapiens_hsa052231.00466317
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98897357
38Influenza A_Homo sapiens_hsa051640.98675662
39Shigellosis_Homo sapiens_hsa051310.95871945
40Platelet activation_Homo sapiens_hsa046110.95636678
41Apoptosis_Homo sapiens_hsa042100.95004242
42Tuberculosis_Homo sapiens_hsa051520.94403578
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92664445
44Rheumatoid arthritis_Homo sapiens_hsa053230.91589030
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91548713
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90579777
47Viral carcinogenesis_Homo sapiens_hsa052030.90308571
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87135041
49TNF signaling pathway_Homo sapiens_hsa046680.85455940
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.84550910
51Colorectal cancer_Homo sapiens_hsa052100.79768081
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78139437
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74591620
54Malaria_Homo sapiens_hsa051440.73909690
55Mismatch repair_Homo sapiens_hsa034300.73492913
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73113556
57VEGF signaling pathway_Homo sapiens_hsa043700.72551358
58FoxO signaling pathway_Homo sapiens_hsa040680.67458691
59DNA replication_Homo sapiens_hsa030300.66766194
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66007332
61Spliceosome_Homo sapiens_hsa030400.63147872
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62551762
63Hepatitis C_Homo sapiens_hsa051600.61225798
64mTOR signaling pathway_Homo sapiens_hsa041500.60474666
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59569622
66Small cell lung cancer_Homo sapiens_hsa052220.59364060
67Lysine degradation_Homo sapiens_hsa003100.58768569
68mRNA surveillance pathway_Homo sapiens_hsa030150.57568248
69Prolactin signaling pathway_Homo sapiens_hsa049170.57500068
70Type I diabetes mellitus_Homo sapiens_hsa049400.54560961
71Inositol phosphate metabolism_Homo sapiens_hsa005620.53670615
72MAPK signaling pathway_Homo sapiens_hsa040100.52525934
73MicroRNAs in cancer_Homo sapiens_hsa052060.51765114
74African trypanosomiasis_Homo sapiens_hsa051430.51665195
75Prostate cancer_Homo sapiens_hsa052150.51418792
76Renal cell carcinoma_Homo sapiens_hsa052110.50621248
77Ribosome_Homo sapiens_hsa030100.50030400
78Linoleic acid metabolism_Homo sapiens_hsa005910.49270051
79p53 signaling pathway_Homo sapiens_hsa041150.49190886
80Staphylococcus aureus infection_Homo sapiens_hsa051500.48906916
81Pertussis_Homo sapiens_hsa051330.48179175
82Insulin resistance_Homo sapiens_hsa049310.47458705
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45819622
84RNA degradation_Homo sapiens_hsa030180.45370760
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44637889
86Notch signaling pathway_Homo sapiens_hsa043300.44466618
87Legionellosis_Homo sapiens_hsa051340.44043707
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43367236
89Endocytosis_Homo sapiens_hsa041440.42455214
90ABC transporters_Homo sapiens_hsa020100.42407240
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41111189
92Endometrial cancer_Homo sapiens_hsa052130.38048969
93Salmonella infection_Homo sapiens_hsa051320.36651143
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36559462
95Regulation of autophagy_Homo sapiens_hsa041400.34783710
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33520183
97Phagosome_Homo sapiens_hsa041450.33305904
98Glioma_Homo sapiens_hsa052140.32107822
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31934071
100Cell cycle_Homo sapiens_hsa041100.31744799
101Dorso-ventral axis formation_Homo sapiens_hsa043200.30066531
102Choline metabolism in cancer_Homo sapiens_hsa052310.29782057
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.29414324
104Proteoglycans in cancer_Homo sapiens_hsa052050.29262694
105Fanconi anemia pathway_Homo sapiens_hsa034600.26658997
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.26536651
107Phototransduction_Homo sapiens_hsa047440.26402508
108Pathways in cancer_Homo sapiens_hsa052000.25897347
109Homologous recombination_Homo sapiens_hsa034400.25675377
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25024001
111Systemic lupus erythematosus_Homo sapiens_hsa053220.24127073
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.22139398
113Ether lipid metabolism_Homo sapiens_hsa005650.21219186
114Type II diabetes mellitus_Homo sapiens_hsa049300.20642234
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.20037036
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20036685
117Glycerolipid metabolism_Homo sapiens_hsa005610.18490956
118HIF-1 signaling pathway_Homo sapiens_hsa040660.16257185
119ErbB signaling pathway_Homo sapiens_hsa040120.16238681
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14666891
121GnRH signaling pathway_Homo sapiens_hsa049120.14498253
122Olfactory transduction_Homo sapiens_hsa047400.14185839
123Ras signaling pathway_Homo sapiens_hsa040140.13938809
124Cholinergic synapse_Homo sapiens_hsa047250.11096429

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