IKZF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.31087962
2negative thymic T cell selection (GO:0045060)4.84201415
3regulation of T cell tolerance induction (GO:0002664)4.69236652
4negative T cell selection (GO:0043383)4.67789361
5somite development (GO:0061053)4.52148805
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.30564820
7regulation of regulatory T cell differentiation (GO:0045589)4.11570826
8nucleobase catabolic process (GO:0046113)4.10761725
9behavioral response to nicotine (GO:0035095)3.98793807
10neuron cell-cell adhesion (GO:0007158)3.98269682
11presynaptic membrane organization (GO:0097090)3.90792160
12regulation of isotype switching to IgG isotypes (GO:0048302)3.87404061
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87109159
14T cell selection (GO:0045058)3.80262218
15thymic T cell selection (GO:0045061)3.75717076
16response to pheromone (GO:0019236)3.67019214
17regulation of interleukin-2 biosynthetic process (GO:0045076)3.60201920
18epithelial cilium movement (GO:0003351)3.55392873
19regulation of T-helper 1 cell differentiation (GO:0045625)3.46253882
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42712836
21protein localization to synapse (GO:0035418)3.41970633
22cellular response to interleukin-15 (GO:0071350)3.33930424
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.33272328
24regulation of translation, ncRNA-mediated (GO:0045974)3.33272328
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33272328
26cilium movement (GO:0003341)3.31472519
27intraciliary transport (GO:0042073)3.31438355
28behavioral response to ethanol (GO:0048149)3.29806774
29spinal cord development (GO:0021510)3.28980047
30nonmotile primary cilium assembly (GO:0035058)3.27685835
31regulation of meiosis I (GO:0060631)3.23046762
32postsynaptic membrane organization (GO:0001941)3.22883355
33vocalization behavior (GO:0071625)3.21227566
34regulation of tolerance induction (GO:0002643)3.20100234
35interferon-gamma production (GO:0032609)3.18998786
36retinal cone cell development (GO:0046549)3.16747307
37protein polyglutamylation (GO:0018095)3.16535162
38positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.12322874
39positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08981143
40tolerance induction (GO:0002507)3.07869589
41positive regulation of interleukin-2 production (GO:0032743)3.07214075
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05792522
43retinal ganglion cell axon guidance (GO:0031290)3.04193976
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04134237
45regulation of glutamate receptor signaling pathway (GO:1900449)3.03775518
46regulation of immunoglobulin secretion (GO:0051023)3.02997197
47neural tube formation (GO:0001841)3.01607869
48hindbrain development (GO:0030902)3.00647356
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.00336390
50negative regulation of DNA recombination (GO:0045910)2.99688835
51axoneme assembly (GO:0035082)2.99673048
52regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.99394211
53regulation of alpha-beta T cell proliferation (GO:0046640)2.97911853
54response to interleukin-15 (GO:0070672)2.97485503
55positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.96776918
56regulation of telomere maintenance (GO:0032204)2.96519778
57neuron fate determination (GO:0048664)2.96344822
58limb bud formation (GO:0060174)2.96104156
59cilium morphogenesis (GO:0060271)2.94587095
60transmission of nerve impulse (GO:0019226)2.93745855
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93615580
62negative regulation of cell killing (GO:0031342)2.93615580
63gamma-aminobutyric acid transport (GO:0015812)2.91840597
64positive regulation of humoral immune response (GO:0002922)2.91570416
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91378962
66axonemal dynein complex assembly (GO:0070286)2.91218146
67positive T cell selection (GO:0043368)2.91020563
68regulation of chronic inflammatory response (GO:0002676)2.88091705
69nephron tubule morphogenesis (GO:0072078)2.87510668
70nephron epithelium morphogenesis (GO:0072088)2.87510668
71tachykinin receptor signaling pathway (GO:0007217)2.85495209
72synaptic transmission, cholinergic (GO:0007271)2.82823012
73CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.82675951
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81591856
75dendritic spine morphogenesis (GO:0060997)2.81087966
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81020749
77kidney morphogenesis (GO:0060993)2.80846562
78positive regulation of gastrulation (GO:2000543)2.80731486
79membrane depolarization during action potential (GO:0086010)2.78517554
80histone H3-K9 methylation (GO:0051567)2.78325705
81head development (GO:0060322)2.77156198
82glutamate receptor signaling pathway (GO:0007215)2.76172443
83neuron recognition (GO:0008038)2.75886334
84spinal cord association neuron differentiation (GO:0021527)2.75741448
85protein localization to cilium (GO:0061512)2.75696773
86startle response (GO:0001964)2.75391328
87substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.74974441
88substrate-independent telencephalic tangential migration (GO:0021826)2.74974441
89cilium assembly (GO:0042384)2.74647363
90cilium organization (GO:0044782)2.74233969
91positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.74231742
92regulation of hypersensitivity (GO:0002883)2.73397196
93T-helper cell differentiation (GO:0042093)2.73113079
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.73113079
95positive regulation of T-helper cell differentiation (GO:0045624)2.73041046
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73027043
97regulation of cilium movement (GO:0003352)2.72670159
98regulation of T-helper cell differentiation (GO:0045622)2.72314392
99cell differentiation in spinal cord (GO:0021515)2.72303917
100regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.71483876
101positive regulation of gamma-delta T cell activation (GO:0046645)2.71200955
102CD4-positive, alpha-beta T cell activation (GO:0035710)2.71153413
103response to prostaglandin E (GO:0034695)2.67525204
104regulation of memory T cell differentiation (GO:0043380)2.66734007
105neuromuscular synaptic transmission (GO:0007274)2.66031478
106ubiquinone metabolic process (GO:0006743)2.66030681
107mRNA splice site selection (GO:0006376)2.65720383
108presynaptic membrane assembly (GO:0097105)2.64166092
109histone H3-K4 trimethylation (GO:0080182)2.63557485
110positive regulation of interleukin-4 production (GO:0032753)2.63116378
111negative regulation of telomere maintenance (GO:0032205)2.63049899
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62716272
113histone H2A acetylation (GO:0043968)2.61385383
114synaptic transmission, glutamatergic (GO:0035249)2.61203621
115myeloid dendritic cell differentiation (GO:0043011)2.60837767
116spinal cord motor neuron differentiation (GO:0021522)2.59474241
117central nervous system neuron axonogenesis (GO:0021955)2.58918268
118ubiquinone biosynthetic process (GO:0006744)2.58865358
119microtubule depolymerization (GO:0007019)2.58692245
120synapse assembly (GO:0007416)2.57937457
121appendage development (GO:0048736)2.57802850
122limb development (GO:0060173)2.57802850
123short-term memory (GO:0007614)2.57635018
124dendrite morphogenesis (GO:0048813)2.57180078
125synaptic vesicle exocytosis (GO:0016079)2.56084481
126alpha-beta T cell differentiation (GO:0046632)2.55552526
127neuronal action potential (GO:0019228)2.55277093
128forebrain neuron differentiation (GO:0021879)2.54684715
129DNA integration (GO:0015074)2.54594795
130cell migration in hindbrain (GO:0021535)2.54570533
131regulation of synaptic vesicle exocytosis (GO:2000300)2.54327132
132alpha-beta T cell activation (GO:0046631)2.53376608
133central nervous system projection neuron axonogenesis (GO:0021952)2.52916110
134cerebral cortex radially oriented cell migration (GO:0021799)2.52651111
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52637625
136regulation of synapse structural plasticity (GO:0051823)2.52578480
137regulation of vesicle fusion (GO:0031338)2.51508915
138cilium or flagellum-dependent cell motility (GO:0001539)2.51322601
139exploration behavior (GO:0035640)2.50728231
140negative regulation of oligodendrocyte differentiation (GO:0048715)2.49742743
141negative regulation of astrocyte differentiation (GO:0048712)2.49583195
142T cell costimulation (GO:0031295)2.49277634
143smoothened signaling pathway (GO:0007224)2.49150747
144response to histamine (GO:0034776)2.48933812
145olfactory bulb development (GO:0021772)2.48820126
146auditory behavior (GO:0031223)2.48614473
147fatty acid elongation (GO:0030497)2.48334434
148regulation of T-helper 2 cell differentiation (GO:0045628)2.47826842
149negative regulation of glial cell differentiation (GO:0045686)2.47750727
150lymphocyte costimulation (GO:0031294)2.47171558
151mannosylation (GO:0097502)2.45775838
152regulation of T-helper 1 type immune response (GO:0002825)2.45768455
153CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.45165667
154regulation of interleukin-4 production (GO:0032673)2.45038292
155cerebellar Purkinje cell differentiation (GO:0021702)2.44523939
156neurotransmitter-gated ion channel clustering (GO:0072578)2.43893328
157regulation of synaptic vesicle transport (GO:1902803)2.43693442
158neuronal action potential propagation (GO:0019227)2.43330310
159T cell migration (GO:0072678)2.42997502
160regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42963969
161renal tubule morphogenesis (GO:0061333)2.42489376
162T cell lineage commitment (GO:0002360)2.41543743
163negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41122805
164layer formation in cerebral cortex (GO:0021819)2.41044377
165regulation of microtubule-based movement (GO:0060632)2.39641145
166positive thymic T cell selection (GO:0045059)2.39035472
167gamma-aminobutyric acid signaling pathway (GO:0007214)2.38507757
168regulation of feeding behavior (GO:0060259)2.38095413
169membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37984814
170tyrosine phosphorylation of STAT protein (GO:0007260)2.37623686
171myeloid dendritic cell activation (GO:0001773)2.37498047
172negative regulation of B cell mediated immunity (GO:0002713)2.37173979
173T cell receptor signaling pathway (GO:0050852)2.36621172
174axonal fasciculation (GO:0007413)2.34947669
175positive regulation of filopodium assembly (GO:0051491)2.34708143
176positive regulation of synapse assembly (GO:0051965)2.34333809
177regulation of timing of cell differentiation (GO:0048505)2.33611168
178T cell differentiation involved in immune response (GO:0002292)2.33288640
179alpha-beta T cell differentiation involved in immune response (GO:0002293)2.33288640
180alpha-beta T cell activation involved in immune response (GO:0002287)2.33288640
181regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.31912216
182synaptic vesicle docking involved in exocytosis (GO:0016081)2.31068607
183negative regulation of T cell mediated immunity (GO:0002710)2.30655078
184positive regulation of T-helper 1 type immune response (GO:0002827)2.29923247
185righting reflex (GO:0060013)2.28933454
186locomotory exploration behavior (GO:0035641)2.27893439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82091031
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37774512
3ZNF274_21170338_ChIP-Seq_K562_Hela3.35839972
4GBX2_23144817_ChIP-Seq_PC3_Human3.27343964
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03676904
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98264430
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.53991848
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52278701
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.49916673
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42711796
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.35813216
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35013200
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34623364
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.32335722
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.29392441
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17943541
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12820360
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12201530
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10985219
20TAF15_26573619_Chip-Seq_HEK293_Human2.03326641
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03019660
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97673515
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96287807
24AR_21572438_ChIP-Seq_LNCaP_Human1.95432352
25* RNF2_27304074_Chip-Seq_NSC_Mouse1.94580595
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93137517
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93137517
28IGF1R_20145208_ChIP-Seq_DFB_Human1.92461191
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90455567
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.90441504
31REST_21632747_ChIP-Seq_MESCs_Mouse1.88654858
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88563324
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87258745
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84747590
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.84247612
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83671753
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.80429292
38P300_19829295_ChIP-Seq_ESCs_Human1.80252184
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.78999500
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78044235
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75471851
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75203528
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74679614
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71012001
45DROSHA_22980978_ChIP-Seq_HELA_Human1.69014701
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66861334
47SMAD4_21799915_ChIP-Seq_A2780_Human1.66074296
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64680610
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57383748
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55106624
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54903762
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54102682
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.52927235
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51814156
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48079666
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47479553
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46926916
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45951448
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45951448
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45650407
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.44779171
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43903876
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43242823
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.42906491
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39280395
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39065542
67* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37182022
68* CBP_20019798_ChIP-Seq_JUKART_Human1.37182022
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36559598
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.33747083
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33294131
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.32063863
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29830177
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29762738
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29468849
76SOX9_26525672_Chip-Seq_HEART_Mouse1.28200243
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28131263
78STAT3_23295773_ChIP-Seq_U87_Human1.26982228
79FUS_26573619_Chip-Seq_HEK293_Human1.24634563
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24119894
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24104890
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.23080976
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23058231
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22214146
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.20535073
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.18846930
87* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18222666
88AR_25329375_ChIP-Seq_VCAP_Human1.17918064
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.17839177
90RUNX_20019798_ChIP-Seq_JUKART_Human1.17488809
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16689934
92TP53_22573176_ChIP-Seq_HFKS_Human1.16420626
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16335066
94P53_22387025_ChIP-Seq_ESCs_Mouse1.14725238
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13828336
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13456866
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.12348541
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12282270
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11521079
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11119622
101* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10642117
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09200972
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08798185
104ER_23166858_ChIP-Seq_MCF-7_Human1.08591382
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07677014
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06806955
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.06767153
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06260031
109TCF4_23295773_ChIP-Seq_U87_Human1.06217842
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.06164586
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06099250
112BCAT_22108803_ChIP-Seq_LS180_Human1.05476400
113EWS_26573619_Chip-Seq_HEK293_Human1.04395863
114RUNX2_22187159_ChIP-Seq_PCA_Human1.04329900
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04190633
116VDR_22108803_ChIP-Seq_LS180_Human1.04041710
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.03750081
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.03440967
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.02875604
120KDM2B_26808549_Chip-Seq_REH_Human1.02141039
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02123341
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01928510
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01828374
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01659855
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00596745
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99981660
127SOX2_18555785_Chip-Seq_ESCs_Mouse0.99896618
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.99445598
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.97634036
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96255238
131NANOG_19829295_ChIP-Seq_ESCs_Human0.94221774
132SOX2_19829295_ChIP-Seq_ESCs_Human0.94221774
133TCF4_22108803_ChIP-Seq_LS180_Human0.92429864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.03155764
2MP0005379_endocrine/exocrine_gland_phen3.08784750
3MP0001346_abnormal_lacrimal_gland2.88664633
4MP0004859_abnormal_synaptic_plasticity2.69871568
5MP0003787_abnormal_imprinting2.61936976
6MP0003122_maternal_imprinting2.59917695
7MP0003880_abnormal_central_pattern2.58851403
8MP0005423_abnormal_somatic_nervous2.51774611
9MP0003763_abnormal_thymus_physiology2.43082070
10MP0005671_abnormal_response_to2.35525285
11MP0001348_abnormal_lacrimal_gland2.33291010
12MP0003635_abnormal_synaptic_transmissio2.28447000
13MP0005310_abnormal_salivary_gland2.21647779
14MP0006276_abnormal_autonomic_nervous2.16469429
15MP0005645_abnormal_hypothalamus_physiol2.12063519
16MP0002063_abnormal_learning/memory/cond2.02202858
17MP0005646_abnormal_pituitary_gland2.01149983
18MP0000778_abnormal_nervous_system1.84697488
19MP0009745_abnormal_behavioral_response1.83101020
20MP0002572_abnormal_emotion/affect_behav1.81633139
21MP0001984_abnormal_olfaction1.80919675
22MP0000685_abnormal_immune_system1.79176313
23MP0004147_increased_porphyrin_level1.77881836
24MP0002102_abnormal_ear_morphology1.77415838
25MP0004510_myositis1.73781392
26MP0005387_immune_system_phenotype1.73254599
27MP0001790_abnormal_immune_system1.73254599
28MP0006292_abnormal_olfactory_placode1.72474777
29MP0003121_genomic_imprinting1.72005952
30MP0004270_analgesia1.71628386
31MP0004145_abnormal_muscle_electrophysio1.69806752
32MP0001968_abnormal_touch/_nociception1.65943515
33MP0003890_abnormal_embryonic-extraembry1.64267626
34MP0002184_abnormal_innervation1.62920461
35MP0001502_abnormal_circadian_rhythm1.53785710
36MP0002638_abnormal_pupillary_reflex1.51535164
37MP0001501_abnormal_sleep_pattern1.51458210
38MP0003136_yellow_coat_color1.51437248
39MP0002734_abnormal_mechanical_nocicepti1.49782235
40MP0002277_abnormal_respiratory_mucosa1.49039135
41MP0002064_seizures1.48704991
42MP0002557_abnormal_social/conspecific_i1.47270527
43MP0001529_abnormal_vocalization1.46410325
44MP0001835_abnormal_antigen_presentation1.45764194
45MP0005253_abnormal_eye_physiology1.45344268
46MP0001486_abnormal_startle_reflex1.44660562
47MP0005551_abnormal_eye_electrophysiolog1.44442445
48MP0001293_anophthalmia1.43686982
49MP0003646_muscle_fatigue1.38837599
50MP0000049_abnormal_middle_ear1.38755006
51MP0000569_abnormal_digit_pigmentation1.38456271
52MP0008789_abnormal_olfactory_epithelium1.37361357
53MP0008057_abnormal_DNA_replication1.37210409
54MP0002876_abnormal_thyroid_physiology1.36012042
55MP0010386_abnormal_urinary_bladder1.35360220
56MP0003938_abnormal_ear_development1.34619027
57MP0002148_abnormal_hypersensitivity_rea1.32224775
58MP0002735_abnormal_chemical_nociception1.30426641
59MP0002752_abnormal_somatic_nervous1.27996518
60MP0005000_abnormal_immune_tolerance1.27968868
61MP0004133_heterotaxia1.27736091
62MP0002272_abnormal_nervous_system1.27545800
63MP0001188_hyperpigmentation1.27309201
64MP0004043_abnormal_pH_regulation1.26885795
65MP0005386_behavior/neurological_phenoty1.25688761
66MP0004924_abnormal_behavior1.25688761
67MP0005499_abnormal_olfactory_system1.24946196
68MP0005394_taste/olfaction_phenotype1.24946196
69MP0000613_abnormal_salivary_gland1.24411495
70MP0003119_abnormal_digestive_system1.24324249
71MP0004885_abnormal_endolymph1.24317550
72MP0003866_abnormal_defecation1.24298771
73MP0002234_abnormal_pharynx_morphology1.22873002
74MP0001970_abnormal_pain_threshold1.21087360
75MP0003861_abnormal_nervous_system1.19825497
76MP0000026_abnormal_inner_ear1.18061482
77MP0003724_increased_susceptibility_to1.16410006
78MP0002067_abnormal_sensory_capabilities1.15559683
79MP0008961_abnormal_basal_metabolism1.14597648
80MP0009046_muscle_twitch1.14596001
81MP0002693_abnormal_pancreas_physiology1.14387214
82MP0002822_catalepsy1.12945711
83MP0000647_abnormal_sebaceous_gland1.12627655
84MP0003937_abnormal_limbs/digits/tail_de1.12251095
85MP0000631_abnormal_neuroendocrine_gland1.11311698
86MP0002733_abnormal_thermal_nociception1.10531447
87MP0001800_abnormal_humoral_immune1.09369437
88MP0002152_abnormal_brain_morphology1.08812880
89MP0002653_abnormal_ependyma_morphology1.08527259
90MP0010030_abnormal_orbit_morphology1.08493064
91MP0008995_early_reproductive_senescence1.08489513
92MP0001440_abnormal_grooming_behavior1.07237908
93MP0003698_abnormal_male_reproductive1.07185366
94MP0000566_synostosis1.06993476
95MP0005187_abnormal_penis_morphology1.05346316
96MP0008569_lethality_at_weaning1.04791980
97MP0001905_abnormal_dopamine_level1.02268342
98MP0002723_abnormal_immune_serum1.01988532
99MP0002909_abnormal_adrenal_gland1.01899328
100MP0000372_irregular_coat_pigmentation1.00929320
101MP0002138_abnormal_hepatobiliary_system1.00508035
102MP0001286_abnormal_eye_development0.98758443
103MP0002736_abnormal_nociception_after0.98688974
104MP0001819_abnormal_immune_cell0.96720972
105MP0002420_abnormal_adaptive_immunity0.96237174
106MP0002938_white_spotting0.95559990
107MP0002066_abnormal_motor_capabilities/c0.93660493
108MP0006072_abnormal_retinal_apoptosis0.90469134
109MP0003879_abnormal_hair_cell0.87701105
110MP0003567_abnormal_fetal_cardiomyocyte0.87561186
111MP0001963_abnormal_hearing_physiology0.87250798
112MP0000703_abnormal_thymus_morphology0.86991265
113MP0008877_abnormal_DNA_methylation0.86598263
114MP0005195_abnormal_posterior_eye0.85678710
115MP0002398_abnormal_bone_marrow0.85177361
116MP0004085_abnormal_heartbeat0.84866907
117MP0003942_abnormal_urinary_system0.84086195
118MP0002210_abnormal_sex_determination0.83619432
119MP0004811_abnormal_neuron_physiology0.83113411
120MP0005391_vision/eye_phenotype0.82931574
121MP0002882_abnormal_neuron_morphology0.82780781
122MP0002837_dystrophic_cardiac_calcinosis0.82715163
123MP0003755_abnormal_palate_morphology0.82449583
124MP0003436_decreased_susceptibility_to0.81808602
125MP0000534_abnormal_ureter_morphology0.81265000
126MP0002233_abnormal_nose_morphology0.81150933
127MP0008872_abnormal_physiological_respon0.80909591
128MP0002177_abnormal_outer_ear0.79667529
129MP0009785_altered_susceptibility_to0.79116667
130MP0004742_abnormal_vestibular_system0.78592730
131MP0001929_abnormal_gametogenesis0.78555864
132MP0002452_abnormal_antigen_presenting0.77320188
133MP0006082_CNS_inflammation0.76678548
134MP0000955_abnormal_spinal_cord0.75818025
135MP0002751_abnormal_autonomic_nervous0.71875003
136MP0000716_abnormal_immune_system0.70967236
137MP0003385_abnormal_body_wall0.70620414
138MP0001944_abnormal_pancreas_morphology0.69437393
139MP0004142_abnormal_muscle_tone0.67812605
140MP0001986_abnormal_taste_sensitivity0.65976528
141MP0002405_respiratory_system_inflammati0.65968259
142MP0000678_abnormal_parathyroid_gland0.64515669

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)5.03364695
2Retrobulbar optic neuritis (HP:0100654)3.93881301
3Optic neuritis (HP:0100653)3.93881301
4Chronic hepatic failure (HP:0100626)3.88846269
5Abnormal hair whorl (HP:0010721)3.76553135
6Focal motor seizures (HP:0011153)3.76099022
7Autoimmune hemolytic anemia (HP:0001890)3.71271701
8Type II lissencephaly (HP:0007260)3.63650157
9Febrile seizures (HP:0002373)3.57248753
10Epileptic encephalopathy (HP:0200134)3.38215829
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.24226466
12Nephronophthisis (HP:0000090)3.23106386
13Failure to thrive in infancy (HP:0001531)3.06534484
14Abnormality of T cell number (HP:0011839)2.99075255
15Retinal dysplasia (HP:0007973)2.97914583
16Polyphagia (HP:0002591)2.93980612
17Large eyes (HP:0001090)2.92349139
18Atonic seizures (HP:0010819)2.91612165
19Abnormality of the fingertips (HP:0001211)2.89847234
20Myositis (HP:0100614)2.89321792
21Lissencephaly (HP:0001339)2.87205642
22Progressive cerebellar ataxia (HP:0002073)2.84813245
23Abnormal ciliary motility (HP:0012262)2.81995633
24Broad-based gait (HP:0002136)2.79997194
25Orchitis (HP:0100796)2.79517311
26Cerebellar dysplasia (HP:0007033)2.77490303
27Abnormality of the renal medulla (HP:0100957)2.70633041
28Absent/shortened dynein arms (HP:0200106)2.65808410
29Cystic liver disease (HP:0006706)2.62061428
30Abnormal respiratory motile cilium physiology (HP:0012261)2.58044245
31Pachygyria (HP:0001302)2.48780728
32Lip pit (HP:0100267)2.46625599
33Genital tract atresia (HP:0001827)2.42771318
34Joint swelling (HP:0001386)2.41425447
35Protruding tongue (HP:0010808)2.38739076
36Autoimmune thrombocytopenia (HP:0001973)2.37042064
37Vaginal atresia (HP:0000148)2.34778113
38Drooling (HP:0002307)2.34258728
39Excessive salivation (HP:0003781)2.34258728
40Sclerocornea (HP:0000647)2.34017928
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.33284108
42Hyperglycinemia (HP:0002154)2.31947554
43Focal seizures (HP:0007359)2.31469278
44IgG deficiency (HP:0004315)2.29620196
45Occipital encephalocele (HP:0002085)2.29353905
46Optic nerve hypoplasia (HP:0000609)2.28230238
47Agitation (HP:0000713)2.27594215
48Absence seizures (HP:0002121)2.25668043
49Methylmalonic acidemia (HP:0002912)2.23803581
50T lymphocytopenia (HP:0005403)2.23232348
51Patellar aplasia (HP:0006443)2.22156544
52Decreased circulating renin level (HP:0003351)2.21545551
53Gait imbalance (HP:0002141)2.20215791
54Pulmonary infiltrates (HP:0002113)2.18133777
55Sleep apnea (HP:0010535)2.15168876
56Anencephaly (HP:0002323)2.14909121
57Eosinophilia (HP:0001880)2.10672665
58Hyperventilation (HP:0002883)2.09744835
59Papillary thyroid carcinoma (HP:0002895)2.09412098
60Poor coordination (HP:0002370)2.08154566
61Genetic anticipation (HP:0003743)2.07050736
62Tubulointerstitial nephritis (HP:0001970)2.06842824
63Anophthalmia (HP:0000528)2.06340425
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05823202
65Optic nerve coloboma (HP:0000588)2.05586185
66Septo-optic dysplasia (HP:0100842)2.05177981
67Abnormality of eosinophils (HP:0001879)2.04860062
68Aplasia/Hypoplasia of the patella (HP:0006498)2.04692863
69Limb dystonia (HP:0002451)2.03967614
70Midline defect of the nose (HP:0004122)2.03937499
71Chronic sinusitis (HP:0011109)2.02064998
72Medial flaring of the eyebrow (HP:0010747)2.01768939
73Abnormality of the labia minora (HP:0012880)2.01431132
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00749661
75Abnormal eating behavior (HP:0100738)1.99665680
76Postaxial hand polydactyly (HP:0001162)1.98384378
77Bronchiectasis (HP:0002110)1.97369713
78Hyperkalemia (HP:0002153)1.97235366
79Myokymia (HP:0002411)1.95158167
80Keratoconjunctivitis sicca (HP:0001097)1.92105618
81Generalized hypopigmentation of hair (HP:0011358)1.90777586
82Abnormality of midbrain morphology (HP:0002418)1.90593057
83Molar tooth sign on MRI (HP:0002419)1.90593057
84Postaxial foot polydactyly (HP:0001830)1.89857441
85Pendular nystagmus (HP:0012043)1.89586095
86Recurrent fungal infections (HP:0002841)1.89285741
87Increased number of teeth (HP:0011069)1.88614559
88Colon cancer (HP:0003003)1.87920466
89Progressive inability to walk (HP:0002505)1.87589041
90Rhinitis (HP:0012384)1.85904137
91Shawl scrotum (HP:0000049)1.85329102
92Hypsarrhythmia (HP:0002521)1.85322870
93Visual hallucinations (HP:0002367)1.84634647
94Supernumerary spleens (HP:0009799)1.83870943
95Delayed CNS myelination (HP:0002188)1.83056148
96Trigonocephaly (HP:0000243)1.82476582
97Pancreatic fibrosis (HP:0100732)1.82425876
98Specific learning disability (HP:0001328)1.82235084
99Broad alveolar ridges (HP:0000187)1.81934841
100Congenital primary aphakia (HP:0007707)1.81857225
101EEG with generalized epileptiform discharges (HP:0011198)1.81529002
102Chronic otitis media (HP:0000389)1.80606289
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79926363
104Prominent nasal bridge (HP:0000426)1.79804559
105Hypergammaglobulinemia (HP:0010702)1.79729871
106Chronic mucocutaneous candidiasis (HP:0002728)1.79536613
107Recurrent cutaneous fungal infections (HP:0011370)1.79536613
108Abnormality of T cells (HP:0002843)1.79414837
109Bony spicule pigmentary retinopathy (HP:0007737)1.79284087
110Hip dysplasia (HP:0001385)1.79258776
111Neoplasm of the tracheobronchial system (HP:0100552)1.79178644
112Pancreatic cysts (HP:0001737)1.78506710
113Dandy-Walker malformation (HP:0001305)1.78370016
114Nephrogenic diabetes insipidus (HP:0009806)1.77906247
115True hermaphroditism (HP:0010459)1.77342601
116Narrow forehead (HP:0000341)1.77253521
117Fair hair (HP:0002286)1.76375093
118Volvulus (HP:0002580)1.75927468
119Abnormal respiratory epithelium morphology (HP:0012253)1.74995833
120Abnormal respiratory motile cilium morphology (HP:0005938)1.74995833
121Thin upper lip vermilion (HP:0000219)1.74381196
122Tubulointerstitial abnormality (HP:0001969)1.74329672
123Bilateral microphthalmos (HP:0007633)1.74187895
124Intestinal atresia (HP:0011100)1.73508489
125Tented upper lip vermilion (HP:0010804)1.73091313
126Keratoconjunctivitis (HP:0001096)1.72936636
127Elevated erythrocyte sedimentation rate (HP:0003565)1.72703824
128Growth hormone deficiency (HP:0000824)1.72141676
129Abnormality of the renal cortex (HP:0011035)1.71814275
130Spinal canal stenosis (HP:0003416)1.71207326
131Male pseudohermaphroditism (HP:0000037)1.70954759
132Tubular atrophy (HP:0000092)1.70467048
133Status epilepticus (HP:0002133)1.70167341
134Abnormality of salivation (HP:0100755)1.69983338
135High anterior hairline (HP:0009890)1.69469765
1363-Methylglutaconic aciduria (HP:0003535)1.68879083
137Decreased testicular size (HP:0008734)1.68755262
138Congenital hepatic fibrosis (HP:0002612)1.68672075
139Hypoplastic ischia (HP:0003175)1.68522492
140Dialeptic seizures (HP:0011146)1.68380295
141Preaxial hand polydactyly (HP:0001177)1.67650401
142Short foot (HP:0001773)1.67294695
143Severe combined immunodeficiency (HP:0004430)1.67078799
144Vasculitis (HP:0002633)1.66936095
145Renal dysplasia (HP:0000110)1.66500055
146Ependymoma (HP:0002888)1.65278592
147Esotropia (HP:0000565)1.65200049
148Atelectasis (HP:0100750)1.64786262
149Chronic diarrhea (HP:0002028)1.64017216
150IgA deficiency (HP:0002720)1.63528210
151Panhypogammaglobulinemia (HP:0003139)1.63131808
152Abnormality of incisor morphology (HP:0011063)1.62975783
153Epileptiform EEG discharges (HP:0011182)1.61041312
154Hemoptysis (HP:0002105)1.60904289
155Hypothermia (HP:0002045)1.60903689
156Abnormality of calcium-phosphate metabolism (HP:0100530)1.60613074
157Absent speech (HP:0001344)1.60458681
158Blue irides (HP:0000635)1.59204928
159Granulocytopenia (HP:0001913)1.59198252
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.58333015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.27140677
2SIK33.20079582
3CASK3.16998287
4TXK3.13766451
5MARK12.94947249
6MAP2K72.75760855
7MAPK132.71568566
8BMPR22.58208278
9MAP3K142.46334645
10SIK22.45777581
11NTRK22.45741564
12BCR2.26248046
13NTRK32.16245668
14TRIM281.90580667
15MAP3K41.90257463
16IKBKE1.80467000
17MUSK1.78649678
18MAP3K91.70466428
19MAP3K131.66166096
20EPHA31.64512135
21TNIK1.62728933
22JAK31.61106731
23DYRK31.59826234
24DYRK21.58874236
25MKNK21.58072419
26MAP3K121.57454447
27TAOK31.47998592
28CHUK1.38048582
29BMPR1B1.35883970
30IKBKB1.30498806
31NLK1.30263241
32PINK11.24653534
33STK38L1.24376548
34HIPK21.24367100
35WNK41.21712593
36CDK81.17198624
37PNCK1.15583391
38MKNK11.11063271
39KSR11.10617543
40TYRO31.09865960
41SGK21.08887296
42FGFR21.07335843
43EPHA41.06822326
44DYRK1B1.05379608
45CAMK1G1.03758965
46SYK0.99008242
47OBSCN0.97784273
48SRPK10.94982523
49MAP4K20.92665762
50MAP4K10.92511428
51WNK30.91757963
52INSRR0.90182270
53MAPK150.90028368
54FGFR40.88612569
55TBK10.87577042
56JAK10.87030402
57PASK0.86993714
58DYRK1A0.84064478
59PHKG20.83537811
60PHKG10.83537811
61ERBB30.83493789
62FGFR30.82291868
63FES0.81263198
64TYK20.79997181
65LCK0.78849504
66PAK60.78686471
67MARK20.77672114
68CDK30.77586569
69PRPF4B0.77326866
70SGK4940.74748092
71SGK2230.74748092
72ADRBK20.74418827
73MINK10.73599009
74RAF10.72557212
75RIPK40.71921225
76CAMK1D0.71434331
77PAK30.68425226
78EPHB20.67956398
79UHMK10.67831953
80CDK50.67579629
81PRKCQ0.67224955
82CDK190.67192322
83NUAK10.66215348
84YES10.66083429
85PRKAA10.65569616
86PRKD30.65149934
87CDK90.64715449
88LATS10.64466498
89MAP2K40.64348599
90ZAP700.62522605
91DAPK20.62450155
92CSNK1G30.62158810
93HCK0.60535526
94PLK20.59773913
95NME10.59761386
96PLK40.59049665
97ZAK0.58430796
98VRK10.57758923
99PRKCE0.57366293
100CAMK2A0.57063598
101CAMK10.54348628
102ITK0.53537106
103IRAK10.52842230
104WNK10.52363439
105DAPK10.52128972
106CSNK1E0.51314039
107SGK10.51007160
108MARK30.50636769
109PKN10.49964886
110PRKG10.48350251
111PLK30.47966884
112GRK10.47345154
113BRD40.46944003
114IRAK20.45919967
115PRKD20.45770520
116PIM20.45478855
117IRAK40.44163869
118MAPK80.42693786
119AKT30.42348324
120GSK3B0.42114476
121ERBB20.41899792
122RPS6KA20.41328428
123CSNK1D0.41277300
124ACVR1B0.41101148
125JAK20.39452553
126CSNK1G20.39195024
127MAP3K50.38853832
128STK110.38441589
129BRAF0.38439194
130TAOK10.38311520
131TLK10.38009617
132ATM0.37524119
133BCKDK0.37367412
134PRKCG0.37353957
135PRKACA0.37336722
136EIF2AK20.37057886
137CSNK1G10.36185655
138CSNK1A1L0.35387326
139MAPK90.35118358
140CAMK40.34458003
141PRKCH0.34022365
142MAP2K60.32962208
143PRKCB0.32447707
144MAP3K60.32120757
145SGK30.32074374

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.17932432
2Nicotine addiction_Homo sapiens_hsa050332.76223394
3Autoimmune thyroid disease_Homo sapiens_hsa053202.55252954
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54421951
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53082477
6Type I diabetes mellitus_Homo sapiens_hsa049402.50565709
7Graft-versus-host disease_Homo sapiens_hsa053322.27053968
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25479507
9Basal transcription factors_Homo sapiens_hsa030222.21085035
10Protein export_Homo sapiens_hsa030602.09061165
11Cardiac muscle contraction_Homo sapiens_hsa042602.06342936
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.92922894
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90582426
14Steroid biosynthesis_Homo sapiens_hsa001001.90034716
15Butanoate metabolism_Homo sapiens_hsa006501.87742566
16RNA polymerase_Homo sapiens_hsa030201.85934390
17Propanoate metabolism_Homo sapiens_hsa006401.85653126
18Morphine addiction_Homo sapiens_hsa050321.79270385
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76788465
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72777016
21T cell receptor signaling pathway_Homo sapiens_hsa046601.70942320
22Primary immunodeficiency_Homo sapiens_hsa053401.65820508
23GABAergic synapse_Homo sapiens_hsa047271.62846380
24Basal cell carcinoma_Homo sapiens_hsa052171.61195696
25Hedgehog signaling pathway_Homo sapiens_hsa043401.60434597
26Oxidative phosphorylation_Homo sapiens_hsa001901.54647679
27Glutamatergic synapse_Homo sapiens_hsa047241.54136651
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49499941
29Serotonergic synapse_Homo sapiens_hsa047261.48932349
30Circadian entrainment_Homo sapiens_hsa047131.46767468
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46403547
32Olfactory transduction_Homo sapiens_hsa047401.44116564
33Parkinsons disease_Homo sapiens_hsa050121.41394491
34Alcoholism_Homo sapiens_hsa050341.39369034
35Amphetamine addiction_Homo sapiens_hsa050311.36939419
36Asthma_Homo sapiens_hsa053101.35296932
37Insulin secretion_Homo sapiens_hsa049111.32592051
38Nitrogen metabolism_Homo sapiens_hsa009101.31862011
39Cholinergic synapse_Homo sapiens_hsa047251.31625144
40Fanconi anemia pathway_Homo sapiens_hsa034601.30365648
41Cocaine addiction_Homo sapiens_hsa050301.29919399
42Synaptic vesicle cycle_Homo sapiens_hsa047211.28985875
43Huntingtons disease_Homo sapiens_hsa050161.28985254
44Taste transduction_Homo sapiens_hsa047421.26527672
45Measles_Homo sapiens_hsa051621.25084877
46Dopaminergic synapse_Homo sapiens_hsa047281.24119071
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.22193833
48Long-term potentiation_Homo sapiens_hsa047201.22137221
49Prolactin signaling pathway_Homo sapiens_hsa049171.20615258
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20426860
51Circadian rhythm_Homo sapiens_hsa047101.11679834
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11210916
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.08315047
54mRNA surveillance pathway_Homo sapiens_hsa030151.07469602
55Chemokine signaling pathway_Homo sapiens_hsa040621.07260493
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07089706
57Oxytocin signaling pathway_Homo sapiens_hsa049211.05212889
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03411747
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01977451
60Type II diabetes mellitus_Homo sapiens_hsa049301.01974096
61Long-term depression_Homo sapiens_hsa047300.99033246
62Linoleic acid metabolism_Homo sapiens_hsa005910.95901256
63Renin secretion_Homo sapiens_hsa049240.95831856
64Rheumatoid arthritis_Homo sapiens_hsa053230.94858911
65Hippo signaling pathway_Homo sapiens_hsa043900.93904212
66Viral myocarditis_Homo sapiens_hsa054160.93147689
67TNF signaling pathway_Homo sapiens_hsa046680.91449664
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90394634
69MAPK signaling pathway_Homo sapiens_hsa040100.88187537
70cAMP signaling pathway_Homo sapiens_hsa040240.87400079
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87334052
72Axon guidance_Homo sapiens_hsa043600.87232796
73African trypanosomiasis_Homo sapiens_hsa051430.86988652
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86234801
75Lysine degradation_Homo sapiens_hsa003100.86058378
76Selenocompound metabolism_Homo sapiens_hsa004500.86019217
77ErbB signaling pathway_Homo sapiens_hsa040120.85605603
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84565825
79GnRH signaling pathway_Homo sapiens_hsa049120.84006441
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83448063
81Salivary secretion_Homo sapiens_hsa049700.83377955
82Hepatitis B_Homo sapiens_hsa051610.82111049
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81323971
84Gastric acid secretion_Homo sapiens_hsa049710.81201609
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78673410
86Osteoclast differentiation_Homo sapiens_hsa043800.78417642
87Caffeine metabolism_Homo sapiens_hsa002320.77903039
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76070998
89Systemic lupus erythematosus_Homo sapiens_hsa053220.76017717
90Calcium signaling pathway_Homo sapiens_hsa040200.75924202
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74989250
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74471780
93Ovarian steroidogenesis_Homo sapiens_hsa049130.74311801
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73494999
95Alzheimers disease_Homo sapiens_hsa050100.73120562
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72243512
97Colorectal cancer_Homo sapiens_hsa052100.71774732
98Fatty acid elongation_Homo sapiens_hsa000620.71608623
99One carbon pool by folate_Homo sapiens_hsa006700.70516063
100Homologous recombination_Homo sapiens_hsa034400.69004593
101Phototransduction_Homo sapiens_hsa047440.67625315
102Hematopoietic cell lineage_Homo sapiens_hsa046400.67418547
103Leishmaniasis_Homo sapiens_hsa051400.67152214
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66898742
105Pancreatic cancer_Homo sapiens_hsa052120.66838394
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65624255
107Herpes simplex infection_Homo sapiens_hsa051680.65575100
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.65176495
109Ras signaling pathway_Homo sapiens_hsa040140.64983508
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64508097
111Influenza A_Homo sapiens_hsa051640.64330783
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.62567897
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62538182
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62529610
115RNA transport_Homo sapiens_hsa030130.61162029
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60818862
117Ether lipid metabolism_Homo sapiens_hsa005650.60216468
118Acute myeloid leukemia_Homo sapiens_hsa052210.60192846
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59840257
120ABC transporters_Homo sapiens_hsa020100.59242938
121Spliceosome_Homo sapiens_hsa030400.59227107
122RNA degradation_Homo sapiens_hsa030180.58923697
123Tryptophan metabolism_Homo sapiens_hsa003800.58065969
124Toxoplasmosis_Homo sapiens_hsa051450.57318216
125Gap junction_Homo sapiens_hsa045400.55832947
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54781930
127Estrogen signaling pathway_Homo sapiens_hsa049150.54533394
128Oocyte meiosis_Homo sapiens_hsa041140.53929034
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53574296
130Purine metabolism_Homo sapiens_hsa002300.53288953
131Collecting duct acid secretion_Homo sapiens_hsa049660.53028293
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.52610381
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51449428
134B cell receptor signaling pathway_Homo sapiens_hsa046620.51209001
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51194350
136Pyruvate metabolism_Homo sapiens_hsa006200.50446220
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48979039
138Choline metabolism in cancer_Homo sapiens_hsa052310.48805220
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48194278
140Renal cell carcinoma_Homo sapiens_hsa052110.47904185
141Melanogenesis_Homo sapiens_hsa049160.47789288
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.46934824
143Wnt signaling pathway_Homo sapiens_hsa043100.46662494
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46180418
145Vibrio cholerae infection_Homo sapiens_hsa051100.46110750
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45134631
147Dorso-ventral axis formation_Homo sapiens_hsa043200.44903379
148Glioma_Homo sapiens_hsa052140.44734149
149Notch signaling pathway_Homo sapiens_hsa043300.44642923
150beta-Alanine metabolism_Homo sapiens_hsa004100.44214557
151HTLV-I infection_Homo sapiens_hsa051660.43352233
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42958400
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42485543
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41879168
155Fatty acid biosynthesis_Homo sapiens_hsa000610.41399751
156TGF-beta signaling pathway_Homo sapiens_hsa043500.40814314
157FoxO signaling pathway_Homo sapiens_hsa040680.38790113
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.37698593
159Dilated cardiomyopathy_Homo sapiens_hsa054140.35763995
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32165365

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