IKZF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.72950224
2axon ensheathment in central nervous system (GO:0032291)6.72950224
3negative regulation of neurotransmitter secretion (GO:0046929)5.44700172
4tolerance induction (GO:0002507)5.34649043
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.26299336
6positive regulation of granulocyte differentiation (GO:0030854)5.09568601
7negative regulation of neurotransmitter transport (GO:0051589)4.93383278
8positive regulation of gamma-delta T cell activation (GO:0046645)4.86913162
9positive regulation of alpha-beta T cell proliferation (GO:0046641)4.84055395
10negative thymic T cell selection (GO:0045060)4.59994464
11presynaptic membrane assembly (GO:0097105)4.54931278
12negative T cell selection (GO:0043383)4.46453414
13limb bud formation (GO:0060174)4.36418507
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34068726
15negative regulation of cell killing (GO:0031342)4.34068726
16rRNA catabolic process (GO:0016075)4.29940996
17regulation of B cell receptor signaling pathway (GO:0050855)4.23012370
18regulation of alpha-beta T cell proliferation (GO:0046640)4.19643131
19presynaptic membrane organization (GO:0097090)4.19495826
20response to interleukin-15 (GO:0070672)4.12350326
21cellular response to interleukin-15 (GO:0071350)4.08209479
22T cell migration (GO:0072678)4.00579617
23protein K11-linked deubiquitination (GO:0035871)3.97601485
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95252961
25regulation of gamma-delta T cell differentiation (GO:0045586)3.86380157
26eye photoreceptor cell differentiation (GO:0001754)3.80803702
27photoreceptor cell differentiation (GO:0046530)3.80803702
28negative regulation of NF-kappaB import into nucleus (GO:0042347)3.80293900
29peptidyl-threonine dephosphorylation (GO:0035970)3.78147487
30acrosome assembly (GO:0001675)3.77693720
31histone H3-K4 trimethylation (GO:0080182)3.76720730
32regulation of gamma-delta T cell activation (GO:0046643)3.76283484
33activated T cell proliferation (GO:0050798)3.69754798
34cerebral cortex radially oriented cell migration (GO:0021799)3.67105933
35oligodendrocyte differentiation (GO:0048709)3.66847128
36myelination (GO:0042552)3.62697832
37axon ensheathment (GO:0008366)3.54287784
38ensheathment of neurons (GO:0007272)3.54287784
39negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.49596386
40regulation of cardiac muscle cell contraction (GO:0086004)3.47684359
41interferon-gamma production (GO:0032609)3.45986632
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45102336
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44138377
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44138377
45positive T cell selection (GO:0043368)3.43635497
46negative regulation of T cell mediated immunity (GO:0002710)3.42657867
47organ growth (GO:0035265)3.42433528
48negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)3.35123745
49neuron cell-cell adhesion (GO:0007158)3.34777368
50dendritic cell chemotaxis (GO:0002407)3.29154624
51response to epinephrine (GO:0071871)3.26102540
52peptidyl-lysine trimethylation (GO:0018023)3.20095348
53fatty acid elongation (GO:0030497)3.19477804
54T cell selection (GO:0045058)3.18586170
55dendritic cell migration (GO:0036336)3.18557367
56nonmotile primary cilium assembly (GO:0035058)3.17512202
57negative regulation of bone resorption (GO:0045779)3.16431950
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15874161
59negative regulation of type 2 immune response (GO:0002829)3.09043155
60alpha-beta T cell differentiation (GO:0046632)3.08263058
61positive regulation of protein kinase C signaling (GO:0090037)3.07716779
62monoubiquitinated protein deubiquitination (GO:0035520)3.06349579
63protein K63-linked deubiquitination (GO:0070536)3.00743012
64interkinetic nuclear migration (GO:0022027)3.00430824
65regulation of T-helper 1 type immune response (GO:0002825)2.99973149
66cyclooxygenase pathway (GO:0019371)2.96272403
67positive thymic T cell selection (GO:0045059)2.95996598
68response to inactivity (GO:0014854)2.95486056
69T-helper cell differentiation (GO:0042093)2.95427577
70CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.95427577
71positive regulation of interleukin-2 production (GO:0032743)2.94341080
72regulation of pigment cell differentiation (GO:0050932)2.94314306
73RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93867691
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93072305
75negative regulation of leukocyte mediated immunity (GO:0002704)2.91904872
76thymic T cell selection (GO:0045061)2.90170191
77cellular response to epinephrine stimulus (GO:0071872)2.89794222
78positive regulation of T-helper 1 type immune response (GO:0002827)2.87211861
79nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.87139746
80positive regulation of action potential (GO:0045760)2.86829364
81alpha-beta T cell activation (GO:0046631)2.86772686
82regulation of germinal center formation (GO:0002634)2.86518530
83sleep (GO:0030431)2.85000186
84positive regulation of T cell chemotaxis (GO:0010820)2.84405017
85regulation of T cell chemotaxis (GO:0010819)2.84405017
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.84029891
87amino acid import (GO:0043090)2.83543749
88germinal center formation (GO:0002467)2.81910934
89regulation of isotype switching to IgG isotypes (GO:0048302)2.81005770
90negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79560416
91CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.79550446
92mast cell activation (GO:0045576)2.79027031
93L-fucose catabolic process (GO:0042355)2.78024172
94fucose catabolic process (GO:0019317)2.78024172
95L-fucose metabolic process (GO:0042354)2.78024172
96Rap protein signal transduction (GO:0032486)2.77939030
97regulation of actin filament-based movement (GO:1903115)2.77804246
98retina layer formation (GO:0010842)2.77696636
99lateral sprouting from an epithelium (GO:0060601)2.77010445
100response to muramyl dipeptide (GO:0032495)2.75723165
101regulation of regulatory T cell differentiation (GO:0045589)2.75433902
102positive regulation of B cell differentiation (GO:0045579)2.75113071
103positive regulation of oligodendrocyte differentiation (GO:0048714)2.75060134
104import into cell (GO:0098657)2.74060534
105negative regulation of type I interferon production (GO:0032480)2.73686346
106negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73296380
107thrombin receptor signaling pathway (GO:0070493)2.73250100
108long-chain fatty acid biosynthetic process (GO:0042759)2.72288459
109positive regulation of synapse assembly (GO:0051965)2.72069392
110cell wall macromolecule metabolic process (GO:0044036)2.72012521
111RNA destabilization (GO:0050779)2.71919353
112regulation of T cell receptor signaling pathway (GO:0050856)2.71530227
113nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.71212848
114antigen receptor-mediated signaling pathway (GO:0050851)2.70309663
115regulation of granulocyte differentiation (GO:0030852)2.69826097
116negative regulation of adaptive immune response (GO:0002820)2.68217448
117T cell receptor signaling pathway (GO:0050852)2.68010426
118histone H3-K9 modification (GO:0061647)2.66247427
119neutrophil activation (GO:0042119)2.64790959
120lymphoid progenitor cell differentiation (GO:0002320)2.63655135
121positive regulation of mRNA catabolic process (GO:0061014)2.63623640
122necroptotic process (GO:0070266)2.62624765
123regulation of necroptotic process (GO:0060544)2.62450375
124L-serine transport (GO:0015825)2.62236731
125mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.61477864
126negative regulation of myoblast differentiation (GO:0045662)2.60852089
127response to catecholamine (GO:0071869)2.60127719
128response to monoamine (GO:0071867)2.60127719
129regulation of memory T cell differentiation (GO:0043380)2.59981283
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58634363
131membrane assembly (GO:0071709)2.58495877
132establishment of protein localization to Golgi (GO:0072600)2.57933636
133regulation of T cell mediated cytotoxicity (GO:0001914)2.56911921
134regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.55647112
135positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.55647112
136B cell receptor signaling pathway (GO:0050853)2.53843423
137histone H3-K9 methylation (GO:0051567)2.53215066
138NIK/NF-kappaB signaling (GO:0038061)2.52806685
139alpha-beta T cell activation involved in immune response (GO:0002287)2.52365388
140negative regulation of protein localization to cell surface (GO:2000009)2.52231613
141positive regulation of gliogenesis (GO:0014015)2.51479187
142myelination in peripheral nervous system (GO:0022011)2.50672815
143peripheral nervous system axon ensheathment (GO:0032292)2.50672815
144negative regulation of T-helper cell differentiation (GO:0045623)2.49094652
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49094652
146positive regulation of meiosis (GO:0045836)2.48479725
147regulation of timing of cell differentiation (GO:0048505)2.48318625
148cerebellar granule cell differentiation (GO:0021707)2.47977858
149positive regulation of interleukin-4 production (GO:0032753)2.45292687
150L-amino acid import (GO:0043092)2.44393202
151negative regulation of execution phase of apoptosis (GO:1900118)2.41164991
152neuron remodeling (GO:0016322)2.41048001
153negative regulation of exocytosis (GO:0045920)2.40948769
154serine transport (GO:0032329)2.37471785
155response to methylmercury (GO:0051597)2.37281371
156positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37121277
157cranial nerve development (GO:0021545)2.36620812
158positive regulation of meiotic cell cycle (GO:0051446)2.36195766
159positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34823311
160transmission of nerve impulse (GO:0019226)2.34506164
161forebrain neuron differentiation (GO:0021879)2.33599740
162negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.32960754
163regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32562820
164astrocyte development (GO:0014002)2.32309144
165substantia nigra development (GO:0021762)2.31928565
166positive regulation of T cell cytokine production (GO:0002726)2.31909622
167DNA ligation (GO:0006266)2.31796162
168positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.31441209
169postsynaptic membrane organization (GO:0001941)2.29845033
170negative regulation of synaptic transmission (GO:0050805)2.29017173
171positive regulation of digestive system process (GO:0060456)2.28664541
172adrenergic receptor signaling pathway (GO:0071875)2.27605701
173asymmetric protein localization (GO:0008105)2.26999251
174regulation of rhodopsin mediated signaling pathway (GO:0022400)2.26798857
175mast cell degranulation (GO:0043303)2.26710471
176mast cell activation involved in immune response (GO:0002279)2.26710471
177regulation of collateral sprouting (GO:0048670)2.25482882
178negative regulation of interleukin-10 production (GO:0032693)2.24154573
179positive regulation of glial cell differentiation (GO:0045687)2.23488508
180neuronal action potential propagation (GO:0019227)2.23260737
181regulation of interleukin-5 production (GO:0032674)2.22778439
182sympathetic nervous system development (GO:0048485)2.22583901
183neuron fate determination (GO:0048664)2.21752709
184positive regulation of systemic arterial blood pressure (GO:0003084)2.20245031
185positive regulation of cell fate commitment (GO:0010455)2.20154690
186glial cell differentiation (GO:0010001)2.19704880
187positive regulation of cardiac muscle cell differentiation (GO:2000727)2.19606907
188myelin maintenance (GO:0043217)2.18947583
189regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17411777
190cornea development in camera-type eye (GO:0061303)2.17159014
191regulation of energy homeostasis (GO:2000505)2.15261566
192cellular response to monoamine stimulus (GO:0071868)2.14905121
193cellular response to catecholamine stimulus (GO:0071870)2.14905121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.12055941
2GBX2_23144817_ChIP-Seq_PC3_Human3.36416856
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.32179528
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06081598
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.87617388
6MYB_26560356_Chip-Seq_TH2_Human2.82928029
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77770663
8AR_21572438_ChIP-Seq_LNCaP_Human2.65941327
9GATA1_22025678_ChIP-Seq_K562_Human2.64877835
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59554840
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53574853
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46178695
13RUNX_20019798_ChIP-Seq_JUKART_Human2.45277506
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44981909
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.44363349
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43297598
17TAF15_26573619_Chip-Seq_HEK293_Human2.37397617
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.36451945
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33423669
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30271801
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.27071151
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.25931451
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.22753605
24VDR_22108803_ChIP-Seq_LS180_Human2.17583325
25EZH2_22144423_ChIP-Seq_EOC_Human2.16401785
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14434423
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09811816
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08561209
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08298917
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.07630118
31CBX2_27304074_Chip-Seq_ESCs_Mouse2.06613391
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03908424
33GATA3_26560356_Chip-Seq_TH2_Human2.01339519
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.01033282
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99338676
36FUS_26573619_Chip-Seq_HEK293_Human1.98040117
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97198704
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.95155049
39P300_19829295_ChIP-Seq_ESCs_Human1.93926997
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92104190
41VDR_23849224_ChIP-Seq_CD4+_Human1.90138340
42MYB_26560356_Chip-Seq_TH1_Human1.89629878
43ER_23166858_ChIP-Seq_MCF-7_Human1.88852894
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.86392483
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86130899
46* GATA3_27048872_Chip-Seq_THYMUS_Human1.84252236
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79944634
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79823347
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.76002851
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71513253
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70264243
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69268849
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.69264817
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.69134316
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67727513
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67536220
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67343886
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67343886
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67267274
60SCL_19346495_ChIP-Seq_HPC-7_Human1.67257222
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.64436017
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.63942121
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58236999
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57174035
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56568956
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55630004
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.55155714
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54698910
69EWS_26573619_Chip-Seq_HEK293_Human1.54365611
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53948133
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53496219
72ELK1_19687146_ChIP-ChIP_HELA_Human1.52799932
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.51892687
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51883572
75TP53_18474530_ChIP-ChIP_U2OS_Human1.49609149
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49572601
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49436931
78SPI1_23547873_ChIP-Seq_NB4_Human1.49207094
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48427107
80ZNF274_21170338_ChIP-Seq_K562_Hela1.48170939
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48039251
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.47056457
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.46060020
84TP53_16413492_ChIP-PET_HCT116_Human1.44756137
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43167038
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.42753631
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41458222
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.40914101
89RNF2_27304074_Chip-Seq_NSC_Mouse1.40299546
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37635776
91P53_22387025_ChIP-Seq_ESCs_Mouse1.36015058
92IRF1_19129219_ChIP-ChIP_H3396_Human1.34806604
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34475911
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34434819
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.33844498
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33750699
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33660273
98SMAD4_21799915_ChIP-Seq_A2780_Human1.32366019
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30580770
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29749666
101* FOXP3_21729870_ChIP-Seq_TREG_Human1.28966300
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28468719
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.27489010
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27115699
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26411247
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26393714
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25400131
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25088208
109GATA3_26560356_Chip-Seq_TH1_Human1.24648508
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24356611
111VDR_24787735_ChIP-Seq_THP-1_Human1.24142794
112P300_18555785_Chip-Seq_ESCs_Mouse1.23990075
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23906497
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23382546
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22643880
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22577616
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.22248739
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21751212
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21711669
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21268052
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20073339
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.19661035
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18785651
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18705404
125CIITA_25753668_ChIP-Seq_RAJI_Human1.14672932
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14595947
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.14412464
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.13762034
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.13423923
130GATA2_21666600_ChIP-Seq_HMVEC_Human1.12806488
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11591057
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.11180238
133IGF1R_20145208_ChIP-Seq_DFB_Human1.10550491
134AR_25329375_ChIP-Seq_VCAP_Human1.08457081
135RUNX2_22187159_ChIP-Seq_PCA_Human1.08293432
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.08239361
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.08203196
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06742440
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06742440
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06285406
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06277107
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06277107
143GABP_17652178_ChIP-ChIP_JURKAT_Human1.06163548
144FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06077784
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04824166
146TRIM28_21343339_ChIP-Seq_HEK293_Human1.04692657
147CDX2_22108803_ChIP-Seq_LS180_Human1.04493638
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04280281
149CBP_20019798_ChIP-Seq_JUKART_Human1.03647762
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03647762
151STAT3_23295773_ChIP-Seq_U87_Human1.03415781
152CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03340854
153CRX_20693478_ChIP-Seq_RETINA_Mouse1.03201167
154BCAT_22108803_ChIP-Seq_LS180_Human1.02759408
155FLI1_21867929_ChIP-Seq_TH2_Mouse1.02319162
156PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02187829
157STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01822175
158OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01479850
159SMRT_27268052_Chip-Seq_Bcells_Human0.99357951
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98817481
161KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96230340
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95188895
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.93632023
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93588208
165TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92663050
166UTX_26944678_Chip-Seq_JUKART_Human0.90298305
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89720901
168SALL4_22934838_ChIP-ChIP_CD34+_Human0.88185089
169GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87574060
170MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87318774
171FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86490862
172MAF_26560356_Chip-Seq_TH1_Human0.86097161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.72923609
2MP0003763_abnormal_thymus_physiology3.43058641
3MP0003880_abnormal_central_pattern3.17206973
4MP0001188_hyperpigmentation3.03601254
5MP0005423_abnormal_somatic_nervous2.81202819
6MP0000920_abnormal_myelination2.75721568
7MP0005171_absent_coat_pigmentation2.74906278
8MP0008877_abnormal_DNA_methylation2.65920598
9MP0003656_abnormal_erythrocyte_physiolo2.65108495
10MP0003436_decreased_susceptibility_to2.51055021
11MP0001800_abnormal_humoral_immune2.50921880
12MP0004270_analgesia2.46072580
13MP0005409_darkened_coat_color2.38574033
14MP0001986_abnormal_taste_sensitivity2.35920427
15MP0004742_abnormal_vestibular_system2.22714971
16MP0002723_abnormal_immune_serum2.17694360
17MP0009379_abnormal_foot_pigmentation2.16497148
18MP0000566_synostosis2.12877523
19MP0002138_abnormal_hepatobiliary_system1.97669705
20MP0004147_increased_porphyrin_level1.96890962
21MP0002420_abnormal_adaptive_immunity1.89920744
22MP0001819_abnormal_immune_cell1.89023781
23MP0002452_abnormal_antigen_presenting1.88690696
24MP0003866_abnormal_defecation1.87284496
25MP0002398_abnormal_bone_marrow1.86772921
26MP0000778_abnormal_nervous_system1.86038528
27MP0009333_abnormal_splenocyte_physiolog1.85869281
28MP0001835_abnormal_antigen_presentation1.82296385
29MP0000569_abnormal_digit_pigmentation1.80960582
30MP0004484_altered_response_of1.79578267
31MP0001486_abnormal_startle_reflex1.74235611
32MP0000689_abnormal_spleen_morphology1.72208865
33MP0002009_preneoplasia1.71506036
34MP0001790_abnormal_immune_system1.68108796
35MP0005387_immune_system_phenotype1.68108796
36MP0009785_altered_susceptibility_to1.67488354
37MP0002166_altered_tumor_susceptibility1.67007500
38MP0003938_abnormal_ear_development1.65549644
39MP0003950_abnormal_plasma_membrane1.65406412
40MP0010155_abnormal_intestine_physiology1.63889119
41MP0002722_abnormal_immune_system1.63001375
42MP0002405_respiratory_system_inflammati1.62607861
43MP0002272_abnormal_nervous_system1.60323980
44MP0004381_abnormal_hair_follicle1.59571771
45MP0001529_abnormal_vocalization1.58147593
46MP0002419_abnormal_innate_immunity1.57634004
47MP0001346_abnormal_lacrimal_gland1.57337217
48MP0005310_abnormal_salivary_gland1.56231964
49MP0000716_abnormal_immune_system1.54919651
50MP0000703_abnormal_thymus_morphology1.54463648
51MP0005075_abnormal_melanosome_morpholog1.52396789
52MP0005025_abnormal_response_to1.51019801
53MP0009745_abnormal_behavioral_response1.50793383
54MP0002064_seizures1.49360553
55MP0000631_abnormal_neuroendocrine_gland1.49299208
56MP0001845_abnormal_inflammatory_respons1.45588270
57MP0002734_abnormal_mechanical_nocicepti1.44296720
58MP0001905_abnormal_dopamine_level1.43930199
59MP0006292_abnormal_olfactory_placode1.43011881
60MP0009764_decreased_sensitivity_to1.41765622
61MP0009046_muscle_twitch1.39419219
62MP0002163_abnormal_gland_morphology1.39394661
63MP0003634_abnormal_glial_cell1.37364689
64MP0003635_abnormal_synaptic_transmissio1.36681003
65MP0004885_abnormal_endolymph1.36462519
66MP0004883_abnormal_blood_vessel1.35609491
67MP0005646_abnormal_pituitary_gland1.32277167
68MP0001440_abnormal_grooming_behavior1.32242031
69MP0000685_abnormal_immune_system1.29861461
70MP0001485_abnormal_pinna_reflex1.29549756
71MP0005464_abnormal_platelet_physiology1.28951403
72MP0004134_abnormal_chest_morphology1.27457952
73MP0009250_abnormal_appendicular_skeleto1.27118937
74MP0000465_gastrointestinal_hemorrhage1.25708918
75MP0002572_abnormal_emotion/affect_behav1.24123734
76MP0005551_abnormal_eye_electrophysiolog1.24110136
77MP0004142_abnormal_muscle_tone1.23636715
78MP0005645_abnormal_hypothalamus_physiol1.22548813
79MP0002006_tumorigenesis1.21665859
80MP0002429_abnormal_blood_cell1.20452222
81MP0006072_abnormal_retinal_apoptosis1.19533064
82MP0003195_calcinosis1.19272729
83MP0003724_increased_susceptibility_to1.19247944
84MP0001243_abnormal_dermal_layer1.18174544
85MP0003300_gastrointestinal_ulcer1.17952727
86MP0001968_abnormal_touch/_nociception1.17277886
87MP0002067_abnormal_sensory_capabilities1.16864343
88MP0008995_early_reproductive_senescence1.16287036
89MP0008569_lethality_at_weaning1.14945034
90MP0002184_abnormal_innervation1.11762132
91MP0003172_abnormal_lysosome_physiology1.11732302
92MP0005671_abnormal_response_to1.09439123
93MP0005379_endocrine/exocrine_gland_phen1.09323887
94MP0000049_abnormal_middle_ear1.09306170
95MP0003690_abnormal_glial_cell1.08026673
96MP0003183_abnormal_peptide_metabolism1.07726481
97MP0003303_peritoneal_inflammation1.07652915
98MP0001533_abnormal_skeleton_physiology1.07041910
99MP0002752_abnormal_somatic_nervous1.04895790
100MP0002063_abnormal_learning/memory/cond1.04817629
101MP0005253_abnormal_eye_physiology1.04081924
102MP0002882_abnormal_neuron_morphology1.03868096
103MP0001501_abnormal_sleep_pattern1.00992970
104MP0002751_abnormal_autonomic_nervous1.00839832
105MP0002148_abnormal_hypersensitivity_rea1.00795756
106MP0003937_abnormal_limbs/digits/tail_de0.99289278
107MP0000026_abnormal_inner_ear0.98248971
108MP0002928_abnormal_bile_duct0.97266991
109MP0004924_abnormal_behavior0.97196529
110MP0005386_behavior/neurological_phenoty0.97196529
111MP0001963_abnormal_hearing_physiology0.95645557
112MP0000383_abnormal_hair_follicle0.95177628
113MP0006054_spinal_hemorrhage0.95091844
114MP0004085_abnormal_heartbeat0.95012316
115MP0000372_irregular_coat_pigmentation0.94855198
116MP0002102_abnormal_ear_morphology0.94315175
117MP0001853_heart_inflammation0.94050349
118MP0002876_abnormal_thyroid_physiology0.94034851
119MP0003786_premature_aging0.93510941
120MP0000955_abnormal_spinal_cord0.92772278
121MP0002229_neurodegeneration0.92624001
122MP0001851_eye_inflammation0.92446025
123MP0003011_delayed_dark_adaptation0.91851458
124MP0001545_abnormal_hematopoietic_system0.91761057
125MP0005397_hematopoietic_system_phenotyp0.91761057
126MP0004947_skin_inflammation0.91596502
127MP0003828_pulmonary_edema0.91360251
128MP0005195_abnormal_posterior_eye0.89010279
129MP0003221_abnormal_cardiomyocyte_apopto0.88502210
130MP0004145_abnormal_muscle_electrophysio0.88012858
131MP0002736_abnormal_nociception_after0.87818014
132MP0002177_abnormal_outer_ear0.87606729
133MP0001542_abnormal_bone_strength0.87304764
134MP0008058_abnormal_DNA_repair0.86885473
135MP0008469_abnormal_protein_level0.86167586
136MP0003787_abnormal_imprinting0.85871588
137MP0005164_abnormal_response_to0.85322099
138MP0001879_abnormal_lymphatic_vessel0.85009365
139MP0003137_abnormal_impulse_conducting0.84847473
140MP0008057_abnormal_DNA_replication0.84627479
141MP0001764_abnormal_homeostasis0.84139726
142MP0005167_abnormal_blood-brain_barrier0.82919641
143MP0002277_abnormal_respiratory_mucosa0.81997847
144MP0004859_abnormal_synaptic_plasticity0.81554719
145MP0002938_white_spotting0.80438379
146MP0002735_abnormal_chemical_nociception0.80276414
147MP0001943_abnormal_respiration0.80151251
148MP0005000_abnormal_immune_tolerance0.78033838
149MP0002132_abnormal_respiratory_system0.78029770
150MP0004130_abnormal_muscle_cell0.77933256
151MP0003632_abnormal_nervous_system0.77647724
152MP0008961_abnormal_basal_metabolism0.77055203
153MP0005623_abnormal_meninges_morphology0.76652616
154MP0000427_abnormal_hair_cycle0.75528446
155MP0006276_abnormal_autonomic_nervous0.75303803
156MP0003755_abnormal_palate_morphology0.75274790
157MP0002693_abnormal_pancreas_physiology0.74808793
158MP0009780_abnormal_chondrocyte_physiolo0.74751336
159MP0003943_abnormal_hepatobiliary_system0.73392144
160MP0002066_abnormal_motor_capabilities/c0.73389399
161MP0010678_abnormal_skin_adnexa0.73226011
162MP0000613_abnormal_salivary_gland0.73172332
163MP0008872_abnormal_physiological_respon0.72902424
164MP0002019_abnormal_tumor_incidence0.72194656
165MP0001984_abnormal_olfaction0.71336340
166MP0001970_abnormal_pain_threshold0.70688611
167MP0001919_abnormal_reproductive_system0.70326380
168MP0009384_cardiac_valve_regurgitation0.70182459
169MP0001177_atelectasis0.69956344
170MP0008873_increased_physiological_sensi0.68941787
171MP0005166_decreased_susceptibility_to0.66087793
172MP0006082_CNS_inflammation0.64652555
173MP0009278_abnormal_bone_marrow0.63152639
174MP0004215_abnormal_myocardial_fiber0.63128716
175MP0000609_abnormal_liver_physiology0.62574785
176MP0005220_abnormal_exocrine_pancreas0.62394171

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)4.97958072
2IgG deficiency (HP:0004315)4.44622819
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.19606877
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.19606877
5Thickened helices (HP:0000391)4.08742942
6Parakeratosis (HP:0001036)3.93193463
7T lymphocytopenia (HP:0005403)3.88209482
8Abnormality of T cells (HP:0002843)3.67610057
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.63255019
10Abnormality of T cell physiology (HP:0011840)3.62660540
11Stomatitis (HP:0010280)3.54516438
12Autoimmune hemolytic anemia (HP:0001890)3.25276957
13Aplasia involving bones of the upper limbs (HP:0009823)3.17335646
14Aplasia of the phalanges of the hand (HP:0009802)3.17335646
15Aplasia involving bones of the extremities (HP:0009825)3.17335646
16Split foot (HP:0001839)3.13960689
17Abnormality of B cell number (HP:0010975)3.13201988
18Eczematoid dermatitis (HP:0000976)3.11267129
19Retrobulbar optic neuritis (HP:0100654)3.09738142
20Optic neuritis (HP:0100653)3.09738142
21Alacrima (HP:0000522)3.04809233
22Neurofibrillary tangles (HP:0002185)3.02392287
23Panhypogammaglobulinemia (HP:0003139)3.01169111
24Myositis (HP:0100614)2.94011757
25Absent septum pellucidum (HP:0001331)2.92852559
26Prostate neoplasm (HP:0100787)2.88664700
27Patchy hypopigmentation of hair (HP:0011365)2.87842378
28Abnormality of the prostate (HP:0008775)2.84633283
29IgM deficiency (HP:0002850)2.79916112
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.76562020
31Absent/shortened dynein arms (HP:0200106)2.76562020
32B lymphocytopenia (HP:0010976)2.76488506
33Abnormality of the pons (HP:0007361)2.76483475
34Fibular aplasia (HP:0002990)2.72541454
35Progressive inability to walk (HP:0002505)2.71903363
36White forelock (HP:0002211)2.70898769
37Cupped ear (HP:0000378)2.70110957
38Sensory axonal neuropathy (HP:0003390)2.69858692
39Hypoplasia of the pons (HP:0012110)2.68400036
40Chin dimple (HP:0010751)2.65922021
41Gastrointestinal infarctions (HP:0005244)2.65440224
42Abnormality of the septum pellucidum (HP:0007375)2.64993360
43Dyschromatopsia (HP:0007641)2.62132112
44Oligodactyly (hands) (HP:0001180)2.61524896
45Severe combined immunodeficiency (HP:0004430)2.60129293
46Hematochezia (HP:0002573)2.59921475
47Papilledema (HP:0001085)2.57486947
48Abnormality of the corticospinal tract (HP:0002492)2.55741724
49Orchitis (HP:0100796)2.55231620
50Encephalitis (HP:0002383)2.54882126
51Joint swelling (HP:0001386)2.52401994
52Abnormality of the axillary hair (HP:0100134)2.50970933
53Abnormality of secondary sexual hair (HP:0009888)2.50970933
54Chronic mucocutaneous candidiasis (HP:0002728)2.49617541
55Recurrent cutaneous fungal infections (HP:0011370)2.49617541
56Decreased lacrimation (HP:0000633)2.47477117
57Decreased central vision (HP:0007663)2.47463794
58Keratoconus (HP:0000563)2.47285647
59Increased corneal curvature (HP:0100692)2.47285647
60Keratoconjunctivitis sicca (HP:0001097)2.46206155
61Subaortic stenosis (HP:0001682)2.45358885
62Abnormality of the left ventricular outflow tract (HP:0011103)2.45358885
63Abnormal ciliary motility (HP:0012262)2.45101468
64Keratoconjunctivitis (HP:0001096)2.43625979
65Cutaneous melanoma (HP:0012056)2.41552008
66Humeroradial synostosis (HP:0003041)2.41466369
67Synostosis involving the elbow (HP:0003938)2.41466369
68Septo-optic dysplasia (HP:0100842)2.41458670
69Clumsiness (HP:0002312)2.40707532
70Elevated erythrocyte sedimentation rate (HP:0003565)2.40549069
71Abnormality of eosinophils (HP:0001879)2.39921351
72Hypoplastic pelvis (HP:0008839)2.36016531
73Abnormality of male internal genitalia (HP:0000022)2.35030052
74Duplication of thumb phalanx (HP:0009942)2.34872038
75Agammaglobulinemia (HP:0004432)2.34451842
76Volvulus (HP:0002580)2.32299865
77Vasculitis (HP:0002633)2.32202274
78Recurrent bronchitis (HP:0002837)2.30932381
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29881481
80Neoplasm of the tracheobronchial system (HP:0100552)2.29200628
81Submucous cleft hard palate (HP:0000176)2.28345090
82Alveolar cell carcinoma (HP:0006519)2.26531613
83Chronic diarrhea (HP:0002028)2.25585487
84Glucose intolerance (HP:0000833)2.25532641
85Hyperventilation (HP:0002883)2.23570478
86Pustule (HP:0200039)2.23328885
87Eosinophilia (HP:0001880)2.22775071
88Global brain atrophy (HP:0002283)2.22700176
89Muscle hypertrophy of the lower extremities (HP:0008968)2.19539689
90Increased IgM level (HP:0003496)2.16749403
91Partial duplication of thumb phalanx (HP:0009944)2.16086474
92Anteriorly placed anus (HP:0001545)2.15714620
93Focal motor seizures (HP:0011153)2.15320736
94Recurrent fungal infections (HP:0002841)2.14737870
95Abnormality of the renal cortex (HP:0011035)2.14438091
96Widely spaced teeth (HP:0000687)2.14408518
97Xerostomia (HP:0000217)2.12635957
98IgA deficiency (HP:0002720)2.11475726
99Abnormal respiratory motile cilium physiology (HP:0012261)2.11287516
100Nasolacrimal duct obstruction (HP:0000579)2.11074298
101Leukocytosis (HP:0001974)2.10937041
102Acute necrotizing encephalopathy (HP:0006965)2.10709923
103Renal cortical cysts (HP:0000803)2.09535101
104Medial flaring of the eyebrow (HP:0010747)2.08558116
105Recurrent bacterial skin infections (HP:0005406)2.07961783
106True hermaphroditism (HP:0010459)2.07818622
107Chest pain (HP:0100749)2.07078487
108Neutropenia (HP:0001875)2.06394960
109Anhidrosis (HP:0000970)2.06377473
110Dyskinesia (HP:0100660)2.05969414
111Acute hepatic failure (HP:0006554)2.05628033
112Amyotrophic lateral sclerosis (HP:0007354)2.05229652
113Renal Fanconi syndrome (HP:0001994)2.05120558
114Pancreatic cysts (HP:0001737)2.04802201
115Abnormality of the heme biosynthetic pathway (HP:0010472)2.04023943
116Granulocytopenia (HP:0001913)2.03860783
117Combined immunodeficiency (HP:0005387)2.03069899
118Abnormal respiratory motile cilium morphology (HP:0005938)1.99583401
119Abnormal respiratory epithelium morphology (HP:0012253)1.99583401
120Growth hormone excess (HP:0000845)1.98045273
121Thyroiditis (HP:0100646)1.97194259
122Broad ribs (HP:0000885)1.96926410
123Basal cell carcinoma (HP:0002671)1.95831497
124Megalencephaly (HP:0001355)1.95636474
125Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94942419
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94765570
127Abnormality of the parathyroid morphology (HP:0011766)1.94522279
128Hypoplasia of the uterus (HP:0000013)1.94378850
129Cerebral inclusion bodies (HP:0100314)1.93707215
130Neurodegeneration (HP:0002180)1.93527328
131Facial diplegia (HP:0001349)1.93381548
132Recurrent sinusitis (HP:0011108)1.92673943
133Partial duplication of the phalanx of hand (HP:0009999)1.92280017
134Meningitis (HP:0001287)1.90606110
135Abnormality of the nasal septum (HP:0000419)1.89730088
136Arterial thrombosis (HP:0004420)1.89413604
137Recurrent skin infections (HP:0001581)1.89117647
138Attenuation of retinal blood vessels (HP:0007843)1.88179527
139Mitochondrial inheritance (HP:0001427)1.87359459
140Progressive macrocephaly (HP:0004481)1.87335945
141Carpal bone hypoplasia (HP:0001498)1.87297702
142Febrile seizures (HP:0002373)1.87243495
143Prolonged bleeding time (HP:0003010)1.87126490
144Congenital sensorineural hearing impairment (HP:0008527)1.86990178
145Retinal dysplasia (HP:0007973)1.86278526
146Central scotoma (HP:0000603)1.86205401
147Recurrent abscess formation (HP:0002722)1.86033818
148Autoamputation (HP:0001218)1.85375821
149Pancreatic fibrosis (HP:0100732)1.85200915
150Long clavicles (HP:0000890)1.83650826
151Mediastinal lymphadenopathy (HP:0100721)1.82968364
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.82817904
153Hypoplasia of the iris (HP:0007676)1.82507081
154Increased hepatocellular lipid droplets (HP:0006565)1.82336873
155Menstrual irregularities (HP:0000858)1.79674850
156Termporal pattern (HP:0011008)1.79652602
157Insidious onset (HP:0003587)1.79652602
158Optic nerve hypoplasia (HP:0000609)1.79301308
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78967928
160Pulmonary infiltrates (HP:0002113)1.77397320
161Gait imbalance (HP:0002141)1.77059884
162Recurrent viral infections (HP:0004429)1.76894039
163Hypothermia (HP:0002045)1.76889394
164Mixed hearing impairment (HP:0000410)1.75304942
165Broad-based gait (HP:0002136)1.74748716
166Congenital primary aphakia (HP:0007707)1.72921065
167Vaginal atresia (HP:0000148)1.72707170
168Gingival bleeding (HP:0000225)1.71762171
169Peripheral hypomyelination (HP:0007182)1.71682233
170Anorexia (HP:0002039)1.70851751
171Calf muscle hypertrophy (HP:0008981)1.70435015
172Abnormality of the columella (HP:0009929)1.70374381
173Aplasia/Hypoplasia of the lens (HP:0008063)1.69671158
174Hemoptysis (HP:0002105)1.69024472
175Hypokalemic alkalosis (HP:0001949)1.68227454
176Aplasia/hypoplasia of the uterus (HP:0008684)1.67963842
177Sparse lateral eyebrow (HP:0005338)1.66902250
178Dysdiadochokinesis (HP:0002075)1.66702028
179Abnormality of the nasolacrimal system (HP:0000614)1.66415364
180Abnormal hair whorl (HP:0010721)1.66005861
181Oligodactyly (HP:0012165)1.65862088
182Genital tract atresia (HP:0001827)1.65699172
183Progressive cerebellar ataxia (HP:0002073)1.65698821
184Leukodystrophy (HP:0002415)1.65480317
185Abnormality of the lacrimal duct (HP:0011481)1.65416051
186Symphalangism affecting the phalanges of the hand (HP:0009773)1.63943067
187Optic disc pallor (HP:0000543)1.63502844
188Absent hand (HP:0004050)1.61793923
189Coronal craniosynostosis (HP:0004440)1.59098511
190Absent speech (HP:0001344)1.58481193
191Barrel-shaped chest (HP:0001552)1.57594469
192Steppage gait (HP:0003376)1.56307504
193Abnormality of T cell number (HP:0011839)1.54740994
194Overfolded helix (HP:0000396)1.54362791
195Gastroesophageal reflux (HP:0002020)1.53687044
196Aplasia cutis congenita (HP:0001057)1.53502614
197Morphological abnormality of the middle ear (HP:0008609)1.52695601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.01788349
2TAOK34.00737692
3CASK3.76502665
4RIPK43.18129661
5STK393.02287612
6FRK3.01258298
7MKNK22.74396101
8TNIK2.73384876
9CAMKK22.60621111
10AKT32.59178418
11SIK32.58301688
12EIF2AK32.23555161
13OXSR12.16164522
14BCR2.11346612
15RIPK12.10090748
16PBK2.07087769
17GRK62.03606595
18IKBKE2.02615974
19BMPR1B1.98982295
20PKN11.95166297
21MUSK1.93493417
22MKNK11.86658236
23UHMK11.82122967
24TEC1.74114389
25PNCK1.66071550
26CLK11.52021814
27TYK21.41246133
28MAP3K91.40830781
29MAPK131.39231704
30BRSK21.37246713
31MAPKAPK51.36279351
32MAP4K21.36088899
33MAP3K141.35447197
34EPHB11.33768750
35FGFR21.32752806
36IRAK41.32092763
37CDK191.31983950
38NLK1.31634668
39FGR1.30413713
40GRK71.30345247
41TRIM281.27275533
42PRKCE1.26342621
43NUAK11.25021742
44IRAK21.24985497
45PRKCQ1.23580446
46PRPF4B1.22650121
47STK161.21359981
48VRK11.20611667
49MAP4K11.19781502
50MET1.19032827
51JAK11.14061482
52MARK31.13922766
53BLK1.10816503
54MAP3K131.10624458
55ZAP701.10041474
56DYRK1A1.09557389
57TRPM71.05268173
58MAP2K21.05096659
59IRAK11.05075317
60MAP2K71.04054501
61ACVR1B1.03115040
62CAMK2B1.02561723
63YES11.01484396
64DYRK21.01337362
65LIMK11.00618974
66MAPK70.99980430
67TXK0.98915626
68TNK20.98606466
69BTK0.98533143
70FES0.96889547
71BRD40.96480834
72WNK10.95467672
73CAMKK10.95015094
74TBK10.94977541
75NME10.93594868
76BMPR20.92996524
77DAPK20.91952379
78NTRK30.90617393
79PLK40.88862426
80JAK20.84233124
81FGFR30.84043863
82PASK0.83102505
83SIK20.82686456
84HIPK20.82099345
85NTRK20.81738925
86SGK2230.81469682
87SGK4940.81469682
88MAP3K70.81302704
89CAMK40.81046682
90NEK60.80670320
91EPHA40.80527625
92PDK10.80132440
93CAMK2A0.79016553
94ADRBK10.78602152
95EIF2AK10.78510647
96ERBB40.77404378
97TLK10.74962947
98ROCK20.73511386
99WNK30.73423880
100RPS6KA50.73167319
101EPHA30.72931369
102HCK0.71088376
103LCK0.70210398
104BRAF0.69903506
105ZAK0.68800344
106CAMK2D0.68136001
107PLK20.67193333
108SRPK10.64897357
109WNK40.63966783
110TYRO30.63769655
111IKBKB0.61051801
112CHUK0.60896760
113PIM10.59515415
114PRKG10.58872253
115PINK10.58770626
116JAK30.58468488
117PAK30.55577432
118SGK30.54749804
119CSF1R0.53321188
120PDGFRB0.52618146
121MELK0.52421816
122EIF2AK20.52028222
123MARK10.50263818
124CDK30.49763790
125CDK50.49179540
126ADRBK20.48818954
127CSNK1G30.48563586
128MAP3K20.48017064
129ERBB30.46850685
130DMPK0.45203713
131CDK60.45133953
132TIE10.43823454
133STK38L0.43001961
134CAMK2G0.42394773
135STK100.41832710
136CSNK1G10.39891965
137ITK0.39704569
138SGK10.39069021
139CSNK1A1L0.38264910
140GRK10.38121591
141SYK0.37274680
142SGK20.36615248
143LYN0.35432907
144MAPK150.34899508
145PIK3CG0.34379128
146RPS6KA40.33984531
147CDK140.33735977
148PRKACA0.33665226
149KIT0.33450870
150PIK3CA0.33444327
151CSK0.32809895
152PRKCH0.31951766
153CSNK1D0.30108155
154TAOK10.29883116
155CDK40.28990542

Predicted pathways (KEGG)

RankGene SetZ-score
1RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.82937722
2Regulation of autophagy_Homo sapiens_hsa041402.68379094
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.50574904
4Non-homologous end-joining_Homo sapiens_hsa034502.22517145
5Circadian rhythm_Homo sapiens_hsa047102.12369408
6Phototransduction_Homo sapiens_hsa047442.09622219
7RNA degradation_Homo sapiens_hsa030181.71432996
8Ether lipid metabolism_Homo sapiens_hsa005651.65088450
9Basal transcription factors_Homo sapiens_hsa030221.63768271
10Serotonergic synapse_Homo sapiens_hsa047261.59986061
11Oxidative phosphorylation_Homo sapiens_hsa001901.57594198
12Herpes simplex infection_Homo sapiens_hsa051681.55488725
13TNF signaling pathway_Homo sapiens_hsa046681.55424448
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52080209
15Graft-versus-host disease_Homo sapiens_hsa053321.51172893
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48145063
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45638530
18Rheumatoid arthritis_Homo sapiens_hsa053231.41755254
19Protein export_Homo sapiens_hsa030601.41707932
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38019695
21Legionellosis_Homo sapiens_hsa051341.35473153
22Dorso-ventral axis formation_Homo sapiens_hsa043201.34952397
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33483321
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30957314
25Long-term depression_Homo sapiens_hsa047301.27413148
26Axon guidance_Homo sapiens_hsa043601.25915187
27Morphine addiction_Homo sapiens_hsa050321.25353666
28Autoimmune thyroid disease_Homo sapiens_hsa053201.25050630
29Nicotine addiction_Homo sapiens_hsa050331.24933297
30GABAergic synapse_Homo sapiens_hsa047271.23636368
31Glutamatergic synapse_Homo sapiens_hsa047241.21991739
32Renal cell carcinoma_Homo sapiens_hsa052111.21918381
33FoxO signaling pathway_Homo sapiens_hsa040681.20980923
34Steroid biosynthesis_Homo sapiens_hsa001001.20057696
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19552810
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18075341
37T cell receptor signaling pathway_Homo sapiens_hsa046601.17358213
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17091326
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15825517
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12623446
41Alzheimers disease_Homo sapiens_hsa050101.10057717
42ErbB signaling pathway_Homo sapiens_hsa040121.09845985
43Parkinsons disease_Homo sapiens_hsa050121.09689327
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08189440
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07200041
46Malaria_Homo sapiens_hsa051441.06457974
47Antigen processing and presentation_Homo sapiens_hsa046121.05750717
48Hepatitis B_Homo sapiens_hsa051611.04831439
49Allograft rejection_Homo sapiens_hsa053301.04448714
50Acute myeloid leukemia_Homo sapiens_hsa052211.04008218
51Fatty acid elongation_Homo sapiens_hsa000621.03605978
52Hematopoietic cell lineage_Homo sapiens_hsa046401.02758119
53Taste transduction_Homo sapiens_hsa047421.00962568
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00785126
55Salivary secretion_Homo sapiens_hsa049700.99312237
56Selenocompound metabolism_Homo sapiens_hsa004500.97742531
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97133417
58Olfactory transduction_Homo sapiens_hsa047400.96025439
59Inositol phosphate metabolism_Homo sapiens_hsa005620.95963120
60Non-small cell lung cancer_Homo sapiens_hsa052230.94480912
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.94462843
62mTOR signaling pathway_Homo sapiens_hsa041500.93390055
63Tuberculosis_Homo sapiens_hsa051520.93246025
64Collecting duct acid secretion_Homo sapiens_hsa049660.93240750
65Cholinergic synapse_Homo sapiens_hsa047250.93148312
66Type I diabetes mellitus_Homo sapiens_hsa049400.90278833
67Sphingolipid metabolism_Homo sapiens_hsa006000.89964133
68Staphylococcus aureus infection_Homo sapiens_hsa051500.89639338
69Renin secretion_Homo sapiens_hsa049240.88132943
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.87116564
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86585393
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86339336
73Vibrio cholerae infection_Homo sapiens_hsa051100.85842925
74Chemokine signaling pathway_Homo sapiens_hsa040620.85376356
75Ras signaling pathway_Homo sapiens_hsa040140.84493226
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84178502
77Toxoplasmosis_Homo sapiens_hsa051450.82301194
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82047224
79Long-term potentiation_Homo sapiens_hsa047200.80551634
80Melanoma_Homo sapiens_hsa052180.80525517
81Circadian entrainment_Homo sapiens_hsa047130.80460695
82Asthma_Homo sapiens_hsa053100.80037502
83Primary immunodeficiency_Homo sapiens_hsa053400.79536505
84Prostate cancer_Homo sapiens_hsa052150.78345717
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77884800
86Measles_Homo sapiens_hsa051620.77783413
87Huntingtons disease_Homo sapiens_hsa050160.76009898
88Apoptosis_Homo sapiens_hsa042100.75386757
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75282294
90Calcium signaling pathway_Homo sapiens_hsa040200.75253396
91Dopaminergic synapse_Homo sapiens_hsa047280.74425975
92Cocaine addiction_Homo sapiens_hsa050300.70955298
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70383258
94Influenza A_Homo sapiens_hsa051640.70057873
95Choline metabolism in cancer_Homo sapiens_hsa052310.69821545
96Salmonella infection_Homo sapiens_hsa051320.69004015
97Epstein-Barr virus infection_Homo sapiens_hsa051690.68897353
98Wnt signaling pathway_Homo sapiens_hsa043100.68877828
99RNA transport_Homo sapiens_hsa030130.68741268
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.68700506
101Osteoclast differentiation_Homo sapiens_hsa043800.68620003
102MAPK signaling pathway_Homo sapiens_hsa040100.68046523
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67904618
104African trypanosomiasis_Homo sapiens_hsa051430.67628495
105Hedgehog signaling pathway_Homo sapiens_hsa043400.67323370
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66571135
107Phagosome_Homo sapiens_hsa041450.66225920
108Basal cell carcinoma_Homo sapiens_hsa052170.65000610
109Linoleic acid metabolism_Homo sapiens_hsa005910.64845111
110Gastric acid secretion_Homo sapiens_hsa049710.64575336
111cAMP signaling pathway_Homo sapiens_hsa040240.64454195
112Melanogenesis_Homo sapiens_hsa049160.64167231
113Leishmaniasis_Homo sapiens_hsa051400.63574000
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63279144
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63224393
116Ribosome_Homo sapiens_hsa030100.62960080
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62811258
118Colorectal cancer_Homo sapiens_hsa052100.61893864
119Pancreatic cancer_Homo sapiens_hsa052120.61441357
120Spliceosome_Homo sapiens_hsa030400.61020917
121Propanoate metabolism_Homo sapiens_hsa006400.60543831
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59943689
123Cardiac muscle contraction_Homo sapiens_hsa042600.59732308
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59299953
125Pertussis_Homo sapiens_hsa051330.58062591
126B cell receptor signaling pathway_Homo sapiens_hsa046620.58019579
127Prolactin signaling pathway_Homo sapiens_hsa049170.57382937
128Alcoholism_Homo sapiens_hsa050340.56819735
129Dilated cardiomyopathy_Homo sapiens_hsa054140.55856538
130Type II diabetes mellitus_Homo sapiens_hsa049300.55181969
131Nucleotide excision repair_Homo sapiens_hsa034200.54974892
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54973619
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54428084
134Nitrogen metabolism_Homo sapiens_hsa009100.54139274
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54068461
136Platelet activation_Homo sapiens_hsa046110.53517284
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.53340546
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52302789
139Amphetamine addiction_Homo sapiens_hsa050310.51477622
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.51218172
141Arachidonic acid metabolism_Homo sapiens_hsa005900.51170740
142One carbon pool by folate_Homo sapiens_hsa006700.50769857
143Mismatch repair_Homo sapiens_hsa034300.49830228
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48475797
145mRNA surveillance pathway_Homo sapiens_hsa030150.48098769
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44446694
147Hepatitis C_Homo sapiens_hsa051600.42818482
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42305543
149Insulin resistance_Homo sapiens_hsa049310.41188063
150Shigellosis_Homo sapiens_hsa051310.39708033
151p53 signaling pathway_Homo sapiens_hsa041150.34529932
152Chronic myeloid leukemia_Homo sapiens_hsa052200.34321666
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.33955202

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