IL10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of regulatory T cell differentiation (GO:0045589)9.66298238
2tolerance induction (GO:0002507)7.33325948
3* negative regulation of B cell proliferation (GO:0030889)7.31795621
4regulation of vitamin D biosynthetic process (GO:0060556)6.96763648
5* regulation of chronic inflammatory response (GO:0002676)6.14058439
6positive regulation of heat generation (GO:0031652)5.84951380
7regulation of T-helper 1 cell differentiation (GO:0045625)5.80652741
8positive regulation of chemokine biosynthetic process (GO:0045080)5.75688955
9regulation of fever generation (GO:0031620)5.62632525
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58416962
11negative regulation of cell killing (GO:0031342)5.58416962
12regulation of vitamin metabolic process (GO:0030656)5.44366846
13regulation of isotype switching to IgG isotypes (GO:0048302)5.23159373
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.16774054
15negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.93887016
16negative regulation of T-helper cell differentiation (GO:0045623)4.93887016
17regulation of heat generation (GO:0031650)4.65531440
18leukocyte aggregation (GO:0070486)4.64582710
19type I interferon signaling pathway (GO:0060337)4.53838056
20cellular response to type I interferon (GO:0071357)4.53838056
21negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.50085181
22response to type I interferon (GO:0034340)4.47880895
23* regulation of B cell proliferation (GO:0030888)4.43781258
24* negative regulation of B cell activation (GO:0050869)4.36359626
25cellular response to interleukin-15 (GO:0071350)4.34772042
26glial cell proliferation (GO:0014009)4.31761401
27T-helper cell differentiation (GO:0042093)4.31488476
28CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.31488476
29response to peptidoglycan (GO:0032494)4.29596531
30* negative regulation of interleukin-12 production (GO:0032695)4.27545837
31regulation of chemokine biosynthetic process (GO:0045073)4.26891017
32response to interleukin-15 (GO:0070672)4.24599636
33positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.23305111
34defense response to protozoan (GO:0042832)4.21765401
35negative regulation of T cell differentiation (GO:0045581)4.20162006
36positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.18364134
37lipopolysaccharide-mediated signaling pathway (GO:0031663)4.17675993
38negative thymic T cell selection (GO:0045060)4.11429792
39regulation of podosome assembly (GO:0071801)4.10101088
40lymphocyte costimulation (GO:0031294)4.08912143
41negative T cell selection (GO:0043383)4.02300463
42positive regulation by symbiont of host defense response (GO:0052509)3.97112952
43modulation by symbiont of host defense response (GO:0052031)3.97112952
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97112952
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97112952
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.97112952
47modulation by symbiont of host immune response (GO:0052553)3.97112952
48response to protozoan (GO:0001562)3.96110986
49negative regulation of amino acid transport (GO:0051956)3.93311858
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.90688684
51regulation of mononuclear cell migration (GO:0071675)3.89415417
52positive regulation of NF-kappaB import into nucleus (GO:0042346)3.88299036
53positive regulation of nitric oxide biosynthetic process (GO:0045429)3.87046806
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.85844447
55T-helper 1 type immune response (GO:0042088)3.83990902
56regulation of B cell receptor signaling pathway (GO:0050855)3.82120461
57regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.79325760
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.78808027
59alpha-beta T cell differentiation involved in immune response (GO:0002293)3.77635073
60alpha-beta T cell activation involved in immune response (GO:0002287)3.77635073
61T cell differentiation involved in immune response (GO:0002292)3.77635073
62positive regulation of defense response to virus by host (GO:0002230)3.74431869
63B cell receptor signaling pathway (GO:0050853)3.72605911
64regulation of T-helper cell differentiation (GO:0045622)3.72484201
65positive regulation of gamma-delta T cell activation (GO:0046645)3.72114241
66positive regulation of interferon-alpha production (GO:0032727)3.71421921
67* regulation of interferon-alpha production (GO:0032647)3.71421921
68positive regulation of isotype switching (GO:0045830)3.71239461
69T cell costimulation (GO:0031295)3.70199201
70T cell migration (GO:0072678)3.68078418
71positive thymic T cell selection (GO:0045059)3.66009475
72regulation of interleukin-8 biosynthetic process (GO:0045414)3.65547641
73cytokine production involved in immune response (GO:0002367)3.65145052
74interferon-gamma-mediated signaling pathway (GO:0060333)3.65056241
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.63991496
76T cell lineage commitment (GO:0002360)3.63925576
77immunoglobulin mediated immune response (GO:0016064)3.63631928
78* negative regulation of nitric oxide biosynthetic process (GO:0045019)3.56880944
79macrophage activation involved in immune response (GO:0002281)3.56331633
80T cell selection (GO:0045058)3.55815858
81NIK/NF-kappaB signaling (GO:0038061)3.55495364
82negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.55291753
83cellular response to nicotine (GO:0071316)3.55119047
84* regulation of cytokine secretion involved in immune response (GO:0002739)3.53375091
85tyrosine phosphorylation of STAT protein (GO:0007260)3.52948929
86thymic T cell selection (GO:0045061)3.51254099
87positive regulation of type 2 immune response (GO:0002830)3.50487668
88production of molecular mediator of immune response (GO:0002440)3.49680548
89germinal center formation (GO:0002467)3.48678191
90* regulation of nitric oxide biosynthetic process (GO:0045428)3.47996762
91negative regulation of viral genome replication (GO:0045071)3.47190943
92negative regulation of osteoclast differentiation (GO:0045671)3.46999382
93positive regulation of T-helper cell differentiation (GO:0045624)3.46841956
94positive regulation of acute inflammatory response (GO:0002675)3.46648702
95negative regulation of adaptive immune response (GO:0002820)3.46405036
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45781955
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45781955
98regulation of heterotypic cell-cell adhesion (GO:0034114)3.42105348
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.41799007
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40739764
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.40003398
102positive regulation of B cell differentiation (GO:0045579)3.39993572
103* regulation of MHC class II biosynthetic process (GO:0045346)3.37955089
104negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.35880224
105modulation by symbiont of host cellular process (GO:0044068)3.35854430
106positive regulation of interleukin-12 production (GO:0032735)3.34538086
107regulation of T cell tolerance induction (GO:0002664)3.33804331
108monocyte chemotaxis (GO:0002548)3.29459615
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.28089911
110positive regulation of B cell mediated immunity (GO:0002714)3.26927742
111positive regulation of immunoglobulin mediated immune response (GO:0002891)3.26927742
112adhesion of symbiont to host cell (GO:0044650)3.25874431
113virion attachment to host cell (GO:0019062)3.25874431
114positive regulation of natural killer cell differentiation (GO:0032825)3.25402154
115positive regulation of immunoglobulin production (GO:0002639)3.24991860
116activation of MAPKKK activity (GO:0000185)3.23115613
117antigen processing and presentation of endogenous antigen (GO:0019883)3.22625917
118positive regulation of cytokine biosynthetic process (GO:0042108)3.21688515
119* regulation of interleukin-12 production (GO:0032655)3.21631889
120myeloid dendritic cell differentiation (GO:0043011)3.20377739
121regulation of B cell differentiation (GO:0045577)3.20164913
122* regulation of B cell activation (GO:0050864)3.20070739
123regulation of interleukin-13 production (GO:0032656)3.20032830
124positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.18418308
125regulation of T-helper 1 type immune response (GO:0002825)3.18199261
126* cellular response to lipopolysaccharide (GO:0071222)3.18114189
127T cell mediated immunity (GO:0002456)3.17666685
128positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.17655666
129regulation of interleukin-2 biosynthetic process (GO:0045076)3.17603297
130positive regulation of interleukin-10 production (GO:0032733)3.17236718
131negative regulation of lipid storage (GO:0010888)3.16592208
132positive regulation of interleukin-6 production (GO:0032755)3.15702699
133tryptophan catabolic process (GO:0006569)3.15547652
134indole-containing compound catabolic process (GO:0042436)3.15547652
135indolalkylamine catabolic process (GO:0046218)3.15547652
136* regulation of immunoglobulin production (GO:0002637)3.15109450
137positive regulation of interferon-beta production (GO:0032728)3.14906846
138regulation of immunoglobulin secretion (GO:0051023)3.14863600
139antigen receptor-mediated signaling pathway (GO:0050851)3.14138105
140kynurenine metabolic process (GO:0070189)3.13602646
141negative regulation of acute inflammatory response (GO:0002674)3.11863470
142positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.11760029
143T cell activation involved in immune response (GO:0002286)3.11747666
144negative regulation of alpha-beta T cell differentiation (GO:0046639)3.09838212
145regulation of interferon-gamma biosynthetic process (GO:0045072)3.09255408
146positive T cell selection (GO:0043368)3.09096877
147positive regulation of DNA recombination (GO:0045911)3.08972324
148regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08838206
149regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.08597849
150growth hormone receptor signaling pathway (GO:0060396)3.08188364
151* cellular response to molecule of bacterial origin (GO:0071219)3.07351959
152dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.06453108
153dendritic cell differentiation (GO:0097028)3.06072127
154CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.05145794
155positive regulation of natural killer cell activation (GO:0032816)3.04074785
156* regulation of isotype switching (GO:0045191)3.03932027
157response to muramyl dipeptide (GO:0032495)3.01746366
158regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00633920
159regulation of alkaline phosphatase activity (GO:0010692)3.00049840
160cellular response to interferon-gamma (GO:0071346)2.99863219
161negative regulation of myeloid cell apoptotic process (GO:0033033)2.99539064
162leukocyte cell-cell adhesion (GO:0007159)2.98846422
163regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97902909
164* regulation of NF-kappaB import into nucleus (GO:0042345)2.96842014
165regulation of antigen processing and presentation (GO:0002577)2.96640318
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.95258355
167myeloid dendritic cell activation (GO:0001773)2.95172946
168negative regulation of T cell mediated immunity (GO:0002710)2.94998323
169positive regulation of antigen processing and presentation (GO:0002579)2.94070420
170regulation of interferon-beta biosynthetic process (GO:0045357)2.92335632
171regulation of type 2 immune response (GO:0002828)2.90019298
172regulation of natural killer cell activation (GO:0032814)2.87639731
173positive regulation of interleukin-1 beta secretion (GO:0050718)2.87016065
174regulation of interleukin-1 beta secretion (GO:0050706)2.85998728
175* negative regulation of cytokine production involved in immune response (GO:0002719)2.85400065
176regulation of defense response to virus by host (GO:0050691)2.84738594
177response to interferon-gamma (GO:0034341)2.84527239
178cellular response to exogenous dsRNA (GO:0071360)2.82970520
179regulation of T-helper 2 cell differentiation (GO:0045628)2.82286543
180regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.81856171
181positive regulation of interferon-gamma production (GO:0032729)2.80160514
182eosinophil chemotaxis (GO:0048245)2.80122850
183positive regulation of chemokine production (GO:0032722)2.79992669
184* regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77733309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.71699763
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.03701341
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.26870836
4* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.11248317
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.93155119
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.60568469
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.58193723
8RUNX_20019798_ChIP-Seq_JUKART_Human3.54903293
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.54085856
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04257246
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.98017970
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94120627
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93644021
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80255894
15* MYB_26560356_Chip-Seq_TH2_Human2.73361692
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.72759062
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67194943
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57828506
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57420129
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.54292873
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40493589
22* MAF_26560356_Chip-Seq_TH1_Human2.34643612
23SCL_19346495_ChIP-Seq_HPC-7_Human2.11723393
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.11349645
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06507149
26* MYB_26560356_Chip-Seq_TH1_Human1.95251588
27MYC_22102868_ChIP-Seq_BL_Human1.85134379
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79245173
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77137336
30GATA1_22025678_ChIP-Seq_K562_Human1.76832657
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75017429
32* PU_27001747_Chip-Seq_BMDM_Mouse1.72022477
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.66418221
34GATA3_27048872_Chip-Seq_THYMUS_Human1.65411368
35VDR_24763502_ChIP-Seq_THP-1_Human1.63865136
36* UTX_26944678_Chip-Seq_JUKART_Human1.63167942
37VDR_24787735_ChIP-Seq_THP-1_Human1.62553758
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.56575447
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.53579551
40* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45177958
41* VDR_21846776_ChIP-Seq_THP-1_Human1.43445081
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42884110
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41355106
44* SPI1_23127762_ChIP-Seq_K562_Human1.38828141
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37848236
46* SPI1_23547873_ChIP-Seq_NB4_Human1.37295674
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36279736
48STAT1_20625510_ChIP-Seq_HELA_Human1.31741112
49MAF_26560356_Chip-Seq_TH2_Human1.30951058
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30771467
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28830471
52* GATA3_26560356_Chip-Seq_TH2_Human1.28171411
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24650544
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23963551
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22563063
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22163752
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21214012
58* GATA1_19941826_ChIP-Seq_K562_Human1.20458758
59KDM2B_26808549_Chip-Seq_DND41_Human1.19272103
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.18914243
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18363840
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17904046
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16976551
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14826950
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14816573
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13444607
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.12941814
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.10566327
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04770967
70* GATA2_19941826_ChIP-Seq_K562_Human1.04212524
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.02428200
72* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01993388
73* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00697889
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00308171
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95853469
76* FOXO3_23340844_ChIP-Seq_DLD1_Human0.94662988
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.94328299
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93215314
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92035353
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91413374
81RXR_22108803_ChIP-Seq_LS180_Human0.90715521
82EGR1_19032775_ChIP-ChIP_M12_Human0.89455641
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89013019
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89013019
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89013019
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88757388
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88208953
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88009094
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87906477
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.84347231
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83427726
92* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81634018
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81422298
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.80693982
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80416305
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78473892
97* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77109636
98SMRT_27268052_Chip-Seq_Bcells_Human0.76711263
99* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76018774
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.75838510
101* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75786857
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75372666
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73232192
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71656076
105* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.70530898
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70212313
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.70035817
108* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66862295
109AHR_22903824_ChIP-Seq_MCF-7_Human0.66450387
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.66020979
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65801452
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.65757575
113* PU1_27457419_Chip-Seq_LIVER_Mouse0.65155737
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64560015
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63601491
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63516112
117TFEB_21752829_ChIP-Seq_HELA_Human0.63075408
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63012134
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.62298210
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.62298210
121BRD4_25478319_ChIP-Seq_HGPS_Human0.62236407
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.62141306
123LXR_22158963_ChIP-Seq_LIVER_Mouse0.61741008
124* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.61613547
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.61427682
126SOX2_20726797_ChIP-Seq_SW620_Human0.59583778
127TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.58137753
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.58058496
129* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56985946
130BCL6_27268052_Chip-Seq_Bcells_Human0.56660191
131* CMYC_18555785_Chip-Seq_ESCs_Mouse0.56578453
132* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.56053126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation6.06431143
2MP0001853_heart_inflammation4.21015189
3MP0006082_CNS_inflammation3.79288475
4MP0005310_abnormal_salivary_gland3.74387569
5* MP0005671_abnormal_response_to3.67341907
6MP0005000_abnormal_immune_tolerance3.25851433
7MP0003724_increased_susceptibility_to3.20222046
8MP0004510_myositis3.18606164
9* MP0001800_abnormal_humoral_immune3.07759315
10* MP0003303_peritoneal_inflammation3.03472131
11MP0003436_decreased_susceptibility_to2.97860762
12MP0002933_joint_inflammation2.83370884
13MP0009785_altered_susceptibility_to2.82017902
14* MP0001790_abnormal_immune_system2.77507641
15* MP0005387_immune_system_phenotype2.77507641
16* MP0001835_abnormal_antigen_presentation2.69842746
17MP0004947_skin_inflammation2.64933530
18MP0002139_abnormal_hepatobiliary_system2.55294675
19* MP0002723_abnormal_immune_serum2.50051380
20* MP0002452_abnormal_antigen_presenting2.48643066
21MP0008004_abnormal_stomach_pH2.47641194
22* MP0003300_gastrointestinal_ulcer2.46944823
23MP0003195_calcinosis2.42945347
24* MP0005025_abnormal_response_to2.39468983
25MP0002254_reproductive_system_inflammat2.34296271
26MP0002405_respiratory_system_inflammati2.30353699
27MP0009333_abnormal_splenocyte_physiolog2.30329670
28* MP0003763_abnormal_thymus_physiology2.28856129
29* MP0001819_abnormal_immune_cell2.16045284
30* MP0002420_abnormal_adaptive_immunity2.15439387
31MP0001348_abnormal_lacrimal_gland2.14261939
32* MP0002419_abnormal_innate_immunity1.97348039
33MP0005451_abnormal_body_composition1.96135517
34MP0006054_spinal_hemorrhage1.93520911
35* MP0002398_abnormal_bone_marrow1.86205604
36MP0000465_gastrointestinal_hemorrhage1.85432369
37* MP0002148_abnormal_hypersensitivity_rea1.83155401
38* MP0001845_abnormal_inflammatory_respons1.82631494
39* MP0000716_abnormal_immune_system1.77987267
40MP0000685_abnormal_immune_system1.76437391
41* MP0010155_abnormal_intestine_physiology1.73605134
42MP0005464_abnormal_platelet_physiology1.71794901
43MP0003448_altered_tumor_morphology1.63533874
44MP0005076_abnormal_cell_differentiation1.63513070
45MP0005167_abnormal_blood-brain_barrier1.62134670
46* MP0001663_abnormal_digestive_system1.59217868
47MP0003646_muscle_fatigue1.55016119
48* MP0001533_abnormal_skeleton_physiology1.53552630
49MP0000689_abnormal_spleen_morphology1.52176306
50* MP0002332_abnormal_exercise_endurance1.50684471
51* MP0002722_abnormal_immune_system1.49857288
52MP0002166_altered_tumor_susceptibility1.46437941
53MP0003866_abnormal_defecation1.43471298
54MP0002429_abnormal_blood_cell1.41309854
55MP0003806_abnormal_nucleotide_metabolis1.38843840
56* MP0000703_abnormal_thymus_morphology1.36417370
57* MP0008469_abnormal_protein_level1.29304982
58MP0001545_abnormal_hematopoietic_system1.28347005
59MP0005397_hematopoietic_system_phenotyp1.28347005
60MP0000249_abnormal_blood_vessel1.27509559
61MP0002138_abnormal_hepatobiliary_system1.23430451
62MP0010352_gastrointestinal_tract_polyps1.21199334
63MP0002998_abnormal_bone_remodeling1.18902171
64MP0005058_abnormal_lysosome_morphology1.18365323
65MP0002006_tumorigenesis1.15365664
66MP0003656_abnormal_erythrocyte_physiolo1.11149516
67MP0005166_decreased_susceptibility_to1.07289618
68MP0003453_abnormal_keratinocyte_physiol1.05839967
69MP0009764_decreased_sensitivity_to1.04910371
70* MP0005381_digestive/alimentary_phenotyp1.02708589
71MP0000604_amyloidosis1.02576556
72MP0005647_abnormal_sex_gland1.01228208
73MP0009765_abnormal_xenobiotic_induced1.01205302
74MP0001881_abnormal_mammary_gland0.97848693
75MP0003566_abnormal_cell_adhesion0.97045602
76MP0002837_dystrophic_cardiac_calcinosis0.96749536
77MP0009278_abnormal_bone_marrow0.96164775
78* MP0000343_altered_response_to0.92139112
79* MP0001501_abnormal_sleep_pattern0.91033681
80MP0001851_eye_inflammation0.88175594
81* MP0005023_abnormal_wound_healing0.88001267
82MP0002693_abnormal_pancreas_physiology0.86676861
83* MP0000490_abnormal_crypts_of0.85640711
84MP0004808_abnormal_hematopoietic_stem0.83443378
85MP0003172_abnormal_lysosome_physiology0.83301031
86MP0003091_abnormal_cell_migration0.82135777
87* MP0003075_altered_response_to0.82131141
88MP0000627_abnormal_mammary_gland0.80050606
89* MP0003795_abnormal_bone_structure0.78788056
90MP0009840_abnormal_foam_cell0.76686588
91* MP0005535_abnormal_body_temperature0.76303910
92MP0000858_altered_metastatic_potential0.72694592
93MP0003045_fibrosis0.72692685
94MP0004084_abnormal_cardiac_muscle0.72037962
95MP0002396_abnormal_hematopoietic_system0.71852204
96* MP0009763_increased_sensitivity_to0.70814806
97MP0005410_abnormal_fertilization0.68363603
98MP0005164_abnormal_response_to0.67769710
99MP0003828_pulmonary_edema0.66825011
100MP0003690_abnormal_glial_cell0.65186438
101MP0004043_abnormal_pH_regulation0.63606655
102* MP0005390_skeleton_phenotype0.62771150
103* MP0005266_abnormal_metabolism0.61658295
104MP0008872_abnormal_physiological_respon0.61379831
105MP0003186_abnormal_redox_activity0.61063191
106MP0005448_abnormal_energy_balance0.60143002
107MP0002277_abnormal_respiratory_mucosa0.59701641
108MP0005666_abnormal_adipose_tissue0.59052470
109* MP0000477_abnormal_intestine_morphology0.58150355
110MP0002009_preneoplasia0.55709761
111* MP0008874_decreased_physiological_sensi0.52599038
112MP0010307_abnormal_tumor_latency0.48884746
113MP0002877_abnormal_melanocyte_morpholog0.48663211
114MP0003633_abnormal_nervous_system0.47679637
115MP0003183_abnormal_peptide_metabolism0.47663772
116MP0004883_abnormal_blood_vessel0.46491347
117MP0005334_abnormal_fat_pad0.46449883
118MP0000013_abnormal_adipose_tissue0.46000130
119MP0005379_endocrine/exocrine_gland_phen0.45474138
120MP0000598_abnormal_liver_morphology0.44844641
121MP0003191_abnormal_cellular_cholesterol0.44507025
122MP0002136_abnormal_kidney_physiology0.44043218
123* MP0005165_increased_susceptibility_to0.42519294
124MP0005584_abnormal_enzyme/coenzyme_acti0.42456394
125MP0001191_abnormal_skin_condition0.42125183
126MP0002098_abnormal_vibrissa_morphology0.41446802
127MP0000733_abnormal_muscle_development0.41170502
128* MP0000609_abnormal_liver_physiology0.39705504
129MP0000920_abnormal_myelination0.38665603

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the prostate (HP:0008775)8.18516589
2Abnormality of glycolipid metabolism (HP:0010969)7.31068393
3Abnormality of liposaccharide metabolism (HP:0010968)7.31068393
4Abnormality of glycosphingolipid metabolism (HP:0004343)7.31068393
5Ureteral stenosis (HP:0000071)7.02584316
6Ureteral obstruction (HP:0006000)6.59001985
7Obstructive lung disease (HP:0006536)6.58736792
8Chronic obstructive pulmonary disease (HP:0006510)6.58736792
9Chest pain (HP:0100749)6.18036083
10* Pulmonary infiltrates (HP:0002113)5.89291057
11Vacuolated lymphocytes (HP:0001922)5.33265650
12Stomatitis (HP:0010280)5.18671466
13* Gangrene (HP:0100758)5.12528169
14* Vasculitis (HP:0002633)5.06072359
15* Pulmonary embolism (HP:0002204)5.05999206
16* Hemoptysis (HP:0002105)4.84153697
17Systemic lupus erythematosus (HP:0002725)4.73490981
18Disinhibition (HP:0000734)4.67726978
19Eczematoid dermatitis (HP:0000976)4.63823656
20Elevated erythrocyte sedimentation rate (HP:0003565)4.63479076
21Loss of speech (HP:0002371)4.56430724
22Gastrointestinal infarctions (HP:0005244)4.44249046
23Abnormality of male internal genitalia (HP:0000022)4.41701988
24Dysostosis multiplex (HP:0000943)4.25577492
25Mutism (HP:0002300)4.21634227
26Pulmonary fibrosis (HP:0002206)4.00451561
27* Thrombophlebitis (HP:0004418)3.98163922
28Restrictive lung disease (HP:0002091)3.96898551
29Nuclear cataract (HP:0100018)3.95398005
30* Glomerulopathy (HP:0100820)3.83590154
31* Meningitis (HP:0001287)3.82048223
32Epistaxis (HP:0000421)3.79551218
33Parakeratosis (HP:0001036)3.78824191
34* Abnormality of the pericardium (HP:0001697)3.73663244
35IgM deficiency (HP:0002850)3.72083817
36Increased IgM level (HP:0003496)3.60265560
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.60207364
38B lymphocytopenia (HP:0010976)3.58325100
39Abnormality of B cell number (HP:0010975)3.58325100
40T lymphocytopenia (HP:0005403)3.54360762
41Mediastinal lymphadenopathy (HP:0100721)3.47440319
42* Arterial thrombosis (HP:0004420)3.46691190
43* Abnormality of the pleura (HP:0002103)3.45997235
44Abnormality of T cell number (HP:0011839)3.43730605
45Severe combined immunodeficiency (HP:0004430)3.41503023
46* Polyneuropathy (HP:0001271)3.39112316
47* Optic neuritis (HP:0100653)3.29947870
48* Retrobulbar optic neuritis (HP:0100654)3.29947870
49Abnormality of polysaccharide metabolism (HP:0011012)3.28524282
50Abnormality of glycosaminoglycan metabolism (HP:0004371)3.28524282
51Abnormality of mucopolysaccharide metabolism (HP:0011020)3.28524282
52Fatigue (HP:0012378)3.27944688
53Recurrent bronchitis (HP:0002837)3.26320546
54* Myositis (HP:0100614)3.25332415
55Gingival bleeding (HP:0000225)3.24772959
56Glomerulonephritis (HP:0000099)3.18376273
57Autoimmune thrombocytopenia (HP:0001973)3.13892246
58* Orchitis (HP:0100796)3.11106384
59Recurrent abscess formation (HP:0002722)3.07445570
60Combined immunodeficiency (HP:0005387)3.07187735
61Nausea (HP:0002018)2.99422246
62Autoimmune hemolytic anemia (HP:0001890)2.97368061
63Inappropriate behavior (HP:0000719)2.92444403
64Recurrent fungal infections (HP:0002841)2.91854931
65Mucopolysacchariduria (HP:0008155)2.91661203
66Urinary glycosaminoglycan excretion (HP:0003541)2.91661203
67Abnormality of T cells (HP:0002843)2.89841423
68Neurofibrillary tangles (HP:0002185)2.89398090
69Increased serum ferritin (HP:0003281)2.86589037
70Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.85859758
71Gastrointestinal stroma tumor (HP:0100723)2.81775221
72Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.79896650
73IgA deficiency (HP:0002720)2.78099803
74Apathy (HP:0000741)2.73241064
75* Paresthesia (HP:0003401)2.70177499
76Joint swelling (HP:0001386)2.67879543
77Recurrent bacterial skin infections (HP:0005406)2.67096017
78Recurrent viral infections (HP:0004429)2.66348570
79Progressive neurologic deterioration (HP:0002344)2.65477116
80Diminished motivation (HP:0000745)2.63196850
81Agnosia (HP:0010524)2.62905497
82Spontaneous hematomas (HP:0007420)2.59098765
83* Pancreatitis (HP:0001733)2.57840488
84Diplopia (HP:0000651)2.57535487
85Abnormality of binocular vision (HP:0011514)2.57535487
86Mesangial abnormality (HP:0001966)2.57182794
87Basal ganglia calcification (HP:0002135)2.56381392
88Leukocytosis (HP:0001974)2.53601052
89Metaphyseal irregularity (HP:0003025)2.51751088
90Axonal loss (HP:0003447)2.51586426
91* Arthralgia (HP:0002829)2.51008079
92Periorbital edema (HP:0100539)2.49184947
93Myocardial infarction (HP:0001658)2.43034187
94Facial edema (HP:0000282)2.42851754
95* Cerebral ischemia (HP:0002637)2.41187647
96Peritonitis (HP:0002586)2.39967503
97Hypergammaglobulinemia (HP:0010702)2.38950747
98Amaurosis fugax (HP:0100576)2.38495296
99Recurrent sinusitis (HP:0011108)2.36154449
100Abnormality of T cell physiology (HP:0011840)2.36016535
101Abnormality of iron homeostasis (HP:0011031)2.35937922
102Skin rash (HP:0000988)2.32770692
103Petechiae (HP:0000967)2.31071758
104Generalized aminoaciduria (HP:0002909)2.25445536
105Thyroiditis (HP:0100646)2.24396645
106Abnormality of macrophages (HP:0004311)2.24092942
107Abnormality of the vasculature of the conjunctiva (HP:0008054)2.23973866
108Abnormal platelet function (HP:0011869)2.23874069
109Impaired platelet aggregation (HP:0003540)2.23874069
110Panhypogammaglobulinemia (HP:0003139)2.23133854
111Complement deficiency (HP:0004431)2.20436581
112IgG deficiency (HP:0004315)2.19382448
113Amyloidosis (HP:0011034)2.16310247
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13336753
115Abnormality of transition element cation homeostasis (HP:0011030)2.12838858
116Polycythemia (HP:0001901)2.11693816
117Hematuria (HP:0000790)2.11170924
118Inflammation of the large intestine (HP:0002037)2.10205464
119Prolonged neonatal jaundice (HP:0006579)2.10082565
120Lymphopenia (HP:0001888)2.09816826
121Abnormal platelet volume (HP:0011876)2.09080858
122Abnormality of the basal ganglia (HP:0002134)2.05965462
123* Keratoconjunctivitis sicca (HP:0001097)2.03952627
124Episodic fever (HP:0001954)2.00796535
125Interstitial pulmonary disease (HP:0006530)2.00531432
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.99930350
127Emphysema (HP:0002097)1.99536150
128Abnormality of eosinophils (HP:0001879)1.99383239
129Esophageal varix (HP:0002040)1.97866083
130Poor head control (HP:0002421)1.97819545
131Recurrent gram-negative bacterial infections (HP:0005420)1.97381275
132Skin ulcer (HP:0200042)1.95841681
133Gastrointestinal inflammation (HP:0004386)1.95515319
134Pustule (HP:0200039)1.94274846
135Purpura (HP:0000979)1.93374830
136Increased mean platelet volume (HP:0011877)1.92132728
137* Anorexia (HP:0002039)1.91850243
138Hepatosplenomegaly (HP:0001433)1.91712312
139Sensorimotor neuropathy (HP:0007141)1.90133660
140Neuronal loss in central nervous system (HP:0002529)1.89625847
141Erythroderma (HP:0001019)1.87319500
142* Keratoconjunctivitis (HP:0001096)1.85849063
143Periodontitis (HP:0000704)1.83953726
144Albinism (HP:0001022)1.83681608
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.83296616
146Osteolytic defects of the hand bones (HP:0009699)1.83296616
147Cerebral inclusion bodies (HP:0100314)1.82043990
148Dementia (HP:0000726)1.81353840
149Recurrent skin infections (HP:0001581)1.81131648
150Chronic otitis media (HP:0000389)1.80602248
151Fused cervical vertebrae (HP:0002949)1.80165490
152Personality changes (HP:0000751)1.78733142
153Hematochezia (HP:0002573)1.77938075
154Thoracolumbar scoliosis (HP:0002944)1.76840151
155* Memory impairment (HP:0002354)1.75434605
156Prolonged bleeding time (HP:0003010)1.74721544
157Increased cerebral lipofuscin (HP:0011813)1.73481581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK74.34504637
2NME23.23616862
3DDR22.88205682
4MAP4K12.79795240
5ADRBK22.71935915
6BMPR22.48447492
7MAP3K142.32451324
8MOS2.25572686
9TXK14.3141236
10JAK31.91358760
11TBK11.88307173
12JAK11.83064056
13JAK21.71241170
14ITK1.67597198
15MAP3K31.65830150
16ACVR1B1.65077194
17IKBKE1.64476564
18ZAP701.62145489
19TYK21.47759720
20STK101.42771401
21IRAK41.34284284
22IKBKB1.33669581
23EPHB11.30532729
24LCK1.27691901
25TEC1.25807002
26CDC42BPA1.18830475
27HCK1.10118419
28EPHA31.09456508
29SYK1.08429075
30MAP2K61.08415547
31FGFR41.06633219
32CHUK1.05069159
33TLK11.00964490
34FGFR31.00798515
35IRAK30.92798077
36BTK0.89595779
37PKN10.88623562
38BLK0.88494406
39ABL20.88131360
40DAPK20.87761050
41KIT0.84374063
42CSK0.82797711
43MAP2K30.81596304
44DYRK30.80909295
45TGFBR20.79022657
46ERN10.75898962
47CDK60.73631258
48LATS20.72222048
49FES0.68020693
50PRKCQ0.66284189
51FRK0.65297403
52RIPK40.62640921
53TAOK30.62134921
54STK240.60304616
55MARK30.55689109
56ALK0.55179627
57SIK20.53236194
58FYN0.51976938
59CAMKK20.50248761
60LYN0.49973162
61TRIB30.48867587
62PIM10.48767292
63PDK10.48180990
64LRRK20.46952061
65PRPF4B0.46357282
66GRK60.45963154
67IRAK10.45756212
68MAP4K20.45522223
69CSF1R0.43107100
70RPS6KA40.42580932
71PDPK10.41762263
72HIPK20.40981265
73MAPK40.40065888
74MST40.40012039
75PRKCH0.38342151
76PTK60.37481965
77FGR0.36703694
78MAP3K100.36585856
79TAOK20.36131636
80MAP3K130.35352189
81BMX0.34212660
82CDK120.32940492
83SIK30.32163088
84PDGFRB0.31982790
85ABL10.31732189
86DAPK30.31258023
87MAPK70.30008836
88TAOK10.29824269
89MAPK110.29725862
90CLK10.28688468
91RIPK10.28466175
92CDK90.28129411
93PIM20.25697075
94MELK0.25481457
95ARAF0.24050164
96MAP3K70.23951338
97GSK3A0.23931048
98DMPK0.23468595
99INSR0.23066276
100IRAK20.22169341
101EGFR0.21908429
102CDK40.20952368
103MATK0.20290307
104NEK90.19513231
105IGF1R0.18954272
106EIF2AK20.18466695
107MAP3K10.18057428
108PRKAA20.17671954
109RPS6KA50.16725120
110NLK0.16719442
111CAMK1D0.14683111
112MAP3K110.14554062
113TNK20.14456607
114RPS6KA60.13115828
115MAPKAPK20.12764925
116WNK10.12468404
117PRKCD0.12220085
118CDK140.11939289
119MAPK30.11607172
120CAMK1G0.11524937
121MAP3K50.11390532
122MAP3K20.10791721
123INSRR0.10486920
124DYRK1B0.10478961
125TTN0.09921614
126EIF2AK30.09378479
127MKNK10.09087399
128TYRO30.07892866
129MAPK90.07438785
130GRK50.06602669
131RPS6KL10.06597465
132RPS6KC10.06597465

Predicted pathways (KEGG)

RankGene SetZ-score
1* Autoimmune thyroid disease_Homo sapiens_hsa053205.81213685
2* Asthma_Homo sapiens_hsa053104.51412485
3* Allograft rejection_Homo sapiens_hsa053304.24407896
4* Intestinal immune network for IgA production_Homo sapiens_hsa046723.65211008
5* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.29369209
6* T cell receptor signaling pathway_Homo sapiens_hsa046603.15767785
7* Leishmaniasis_Homo sapiens_hsa051403.03917142
8Primary immunodeficiency_Homo sapiens_hsa053402.69602561
9Hematopoietic cell lineage_Homo sapiens_hsa046402.54945553
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.15571566
11Measles_Homo sapiens_hsa051622.03537552
12Osteoclast differentiation_Homo sapiens_hsa043802.00858781
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96058416
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82963392
15Rheumatoid arthritis_Homo sapiens_hsa053231.81086276
16Graft-versus-host disease_Homo sapiens_hsa053321.74529258
17B cell receptor signaling pathway_Homo sapiens_hsa046621.69703935
18* Jak-STAT signaling pathway_Homo sapiens_hsa046301.64898611
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63516590
20* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59024378
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53153129
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51394538
23* Staphylococcus aureus infection_Homo sapiens_hsa051501.44380503
24TNF signaling pathway_Homo sapiens_hsa046681.43600268
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37940843
26* Toxoplasmosis_Homo sapiens_hsa051451.37867431
27* Malaria_Homo sapiens_hsa051441.35730495
28Chemokine signaling pathway_Homo sapiens_hsa040621.35111886
29* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27284296
30Legionellosis_Homo sapiens_hsa051341.26684107
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23033772
32* Tuberculosis_Homo sapiens_hsa051521.22891255
33* Pertussis_Homo sapiens_hsa051331.15029859
34Antigen processing and presentation_Homo sapiens_hsa046121.12515172
35Type I diabetes mellitus_Homo sapiens_hsa049401.12469737
36Hepatitis B_Homo sapiens_hsa051611.09096774
37Shigellosis_Homo sapiens_hsa051311.07475152
38Influenza A_Homo sapiens_hsa051641.04599858
39Apoptosis_Homo sapiens_hsa042100.97350967
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94423583
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87870458
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87465456
43Herpes simplex infection_Homo sapiens_hsa051680.87257543
44Sulfur metabolism_Homo sapiens_hsa009200.86515034
45Chronic myeloid leukemia_Homo sapiens_hsa052200.86369047
46Collecting duct acid secretion_Homo sapiens_hsa049660.86309924
47Sphingolipid metabolism_Homo sapiens_hsa006000.85730642
48Salmonella infection_Homo sapiens_hsa051320.84521061
49Platelet activation_Homo sapiens_hsa046110.81596559
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.80675506
51Renal cell carcinoma_Homo sapiens_hsa052110.78758761
52* African trypanosomiasis_Homo sapiens_hsa051430.78235782
53Viral myocarditis_Homo sapiens_hsa054160.77777944
54Tryptophan metabolism_Homo sapiens_hsa003800.76360155
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.74328078
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.73945517
57Hepatitis C_Homo sapiens_hsa051600.73535981
58Pancreatic cancer_Homo sapiens_hsa052120.72578425
59Prolactin signaling pathway_Homo sapiens_hsa049170.70881057
60Acute myeloid leukemia_Homo sapiens_hsa052210.69539532
61Small cell lung cancer_Homo sapiens_hsa052220.66191448
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62705974
63Bladder cancer_Homo sapiens_hsa052190.61779183
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59625517
65Type II diabetes mellitus_Homo sapiens_hsa049300.58110895
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56199089
67HTLV-I infection_Homo sapiens_hsa051660.56021759
68Dorso-ventral axis formation_Homo sapiens_hsa043200.54934958
69* Amoebiasis_Homo sapiens_hsa051460.53674485
70Viral carcinogenesis_Homo sapiens_hsa052030.53455880
71VEGF signaling pathway_Homo sapiens_hsa043700.50637324
72MicroRNAs in cancer_Homo sapiens_hsa052060.50349282
73Phagosome_Homo sapiens_hsa041450.49632637
74Lysosome_Homo sapiens_hsa041420.48387184
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48273565
76* Epstein-Barr virus infection_Homo sapiens_hsa051690.45516301
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.45263382
78MAPK signaling pathway_Homo sapiens_hsa040100.44995231
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43382118
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42406434
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41981947
82Proteoglycans in cancer_Homo sapiens_hsa052050.40069363
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.39663383
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39628577
85Insulin resistance_Homo sapiens_hsa049310.39194523
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38552295
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.38229963
88* FoxO signaling pathway_Homo sapiens_hsa040680.35940219
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35797060
90mTOR signaling pathway_Homo sapiens_hsa041500.33125463
91Mineral absorption_Homo sapiens_hsa049780.31599201
92Endocytosis_Homo sapiens_hsa041440.31325981
93HIF-1 signaling pathway_Homo sapiens_hsa040660.31289883
94ErbB signaling pathway_Homo sapiens_hsa040120.30605373
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30023152
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28769885
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28756016
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28473493
99* Systemic lupus erythematosus_Homo sapiens_hsa053220.25824438
100Prostate cancer_Homo sapiens_hsa052150.25112514
101Notch signaling pathway_Homo sapiens_hsa043300.24737980
102Non-small cell lung cancer_Homo sapiens_hsa052230.23847423
103Focal adhesion_Homo sapiens_hsa045100.22814153
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22342777
105Rap1 signaling pathway_Homo sapiens_hsa040150.21347828
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20703102
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20682018
108Prion diseases_Homo sapiens_hsa050200.20412433
109Other glycan degradation_Homo sapiens_hsa005110.20288484
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19380053
111Colorectal cancer_Homo sapiens_hsa052100.19035127
112PPAR signaling pathway_Homo sapiens_hsa033200.18030984
113Ether lipid metabolism_Homo sapiens_hsa005650.18005891
114Complement and coagulation cascades_Homo sapiens_hsa046100.17686401
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17619388
116Inositol phosphate metabolism_Homo sapiens_hsa005620.16796706
117Folate biosynthesis_Homo sapiens_hsa007900.16393233
118Dilated cardiomyopathy_Homo sapiens_hsa054140.15388651
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14569725
120Vibrio cholerae infection_Homo sapiens_hsa051100.12578906
121Pathways in cancer_Homo sapiens_hsa052000.10099540
122Ovarian steroidogenesis_Homo sapiens_hsa049130.07374965
123Arachidonic acid metabolism_Homo sapiens_hsa005900.05323263
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03255341
125Fatty acid biosynthesis_Homo sapiens_hsa000610.03034696
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02843012
127Steroid biosynthesis_Homo sapiens_hsa001000.01773337
128Peroxisome_Homo sapiens_hsa041460.00289459
129Renin-angiotensin system_Homo sapiens_hsa04614-0.0003453

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