IL10RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.05675633
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.05675633
3modulation by symbiont of host immune response (GO:0052553)6.05675633
4positive regulation by symbiont of host defense response (GO:0052509)6.05675633
5modulation by symbiont of host defense response (GO:0052031)6.05675633
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.05675633
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.98167910
8regulation of interferon-beta biosynthetic process (GO:0045357)5.48282630
9macrophage activation involved in immune response (GO:0002281)5.29291107
10regulation of B cell receptor signaling pathway (GO:0050855)5.24832494
11microglial cell activation (GO:0001774)5.16449977
12positive regulation of gamma-delta T cell activation (GO:0046645)4.86314709
13positive regulation of interferon-alpha production (GO:0032727)4.70284236
14antigen processing and presentation of endogenous antigen (GO:0019883)4.65302184
15neutrophil activation involved in immune response (GO:0002283)4.61249667
16regulation of interferon-alpha production (GO:0032647)4.50254366
17immunoglobulin mediated immune response (GO:0016064)4.39526882
18positive regulation of antigen processing and presentation (GO:0002579)4.26938832
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.17435929
20positive regulation of B cell differentiation (GO:0045579)4.07683608
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06592943
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06592943
23response to peptidoglycan (GO:0032494)4.03848052
24detection of other organism (GO:0098543)4.00650661
25response to muramyl dipeptide (GO:0032495)3.96034405
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94327511
27negative regulation of cell killing (GO:0031342)3.94327511
28B cell receptor signaling pathway (GO:0050853)3.88923425
29response to host immune response (GO:0052572)3.86972494
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86972494
31negative regulation of T cell mediated immunity (GO:0002710)3.85930978
32macrophage activation (GO:0042116)3.82958453
33negative regulation of granulocyte differentiation (GO:0030853)3.79992929
34detection of bacterium (GO:0016045)3.79790680
35regulation of B cell differentiation (GO:0045577)3.75687003
36myeloid cell activation involved in immune response (GO:0002275)3.72890772
37respiratory burst (GO:0045730)3.70976089
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.70827608
39neutrophil activation (GO:0042119)3.68034158
40regulation of tolerance induction (GO:0002643)3.66647291
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.65025105
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62896095
43response to host (GO:0075136)3.62896095
44response to host defenses (GO:0052200)3.62896095
45granulocyte activation (GO:0036230)3.61594103
46regulation of antigen processing and presentation (GO:0002577)3.61174693
47interferon-gamma-mediated signaling pathway (GO:0060333)3.57248492
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.57034102
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.55784117
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53948363
51positive regulation of interferon-beta production (GO:0032728)3.48986626
52NIK/NF-kappaB signaling (GO:0038061)3.46401492
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.45185761
54G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.42310544
55regulation of T-helper 1 cell differentiation (GO:0045625)3.39719457
56cellular extravasation (GO:0045123)3.39610727
57I-kappaB phosphorylation (GO:0007252)3.38567805
58positive regulation of tolerance induction (GO:0002645)3.36760695
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34114894
60tolerance induction (GO:0002507)3.30539532
61T cell migration (GO:0072678)3.28468990
62positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.28316182
63regulation of gamma-delta T cell activation (GO:0046643)3.27993189
64germinal center formation (GO:0002467)3.27084891
65detection of external biotic stimulus (GO:0098581)3.26595251
66positive regulation of chemokine secretion (GO:0090197)3.26540551
67regulation of mast cell degranulation (GO:0043304)3.26093656
68positive regulation of type 2 immune response (GO:0002830)3.25965004
69type I interferon signaling pathway (GO:0060337)3.24814449
70cellular response to type I interferon (GO:0071357)3.24814449
71response to type I interferon (GO:0034340)3.24071879
72regulation of gamma-delta T cell differentiation (GO:0045586)3.23983714
73T cell selection (GO:0045058)3.22849706
74response to protozoan (GO:0001562)3.19975509
75myeloid dendritic cell activation (GO:0001773)3.19328229
76myeloid dendritic cell differentiation (GO:0043011)3.19200573
77detection of molecule of bacterial origin (GO:0032490)3.16106391
78negative regulation of leukocyte mediated immunity (GO:0002704)3.15463015
79negative regulation of cytokine production involved in immune response (GO:0002719)3.15230827
80positive regulation of mast cell degranulation (GO:0043306)3.14830311
81positive regulation of mast cell activation involved in immune response (GO:0033008)3.14830311
82regulation of interleukin-2 biosynthetic process (GO:0045076)3.14827356
83B cell mediated immunity (GO:0019724)3.14825668
84negative regulation of erythrocyte differentiation (GO:0045647)3.13011816
85positive regulation of mast cell activation (GO:0033005)3.12654549
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09368037
87positive thymic T cell selection (GO:0045059)3.09127652
88positive regulation of interleukin-12 production (GO:0032735)3.08007894
89interferon-gamma production (GO:0032609)3.07969612
90negative regulation of interleukin-12 production (GO:0032695)3.05500560
91myeloid leukocyte activation (GO:0002274)3.05476579
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.04545306
93response to interleukin-15 (GO:0070672)3.04485521
94regulation of mast cell activation involved in immune response (GO:0033006)3.02362619
95leukocyte aggregation (GO:0070486)3.02323338
96negative regulation of B cell proliferation (GO:0030889)3.01983495
97negative regulation of interleukin-6 production (GO:0032715)3.01222775
98regulation of regulatory T cell differentiation (GO:0045589)3.01188147
99positive regulation of cellular amide metabolic process (GO:0034250)3.01024178
100JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00499757
101production of molecular mediator involved in inflammatory response (GO:0002532)3.00223965
102T-helper 1 type immune response (GO:0042088)2.97372404
103detection of biotic stimulus (GO:0009595)2.96864835
104positive T cell selection (GO:0043368)2.96582275
105thymic T cell selection (GO:0045061)2.93672222
106regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93457753
107regulation of natural killer cell mediated immunity (GO:0002715)2.93457753
108cellular response to zinc ion (GO:0071294)2.93372215
109mature B cell differentiation (GO:0002335)2.90084303
110pinocytosis (GO:0006907)2.89902382
111negative regulation of innate immune response (GO:0045824)2.89539866
112regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89491955
113dendritic cell differentiation (GO:0097028)2.89102003
114regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88784141
115negative thymic T cell selection (GO:0045060)2.88292592
116regulation of type 2 immune response (GO:0002828)2.87521564
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86567199
118regulation of mast cell activation (GO:0033003)2.86465551
119regulation of interleukin-12 production (GO:0032655)2.86255509
120B cell homeostasis (GO:0001782)2.85364021
121defense response to protozoan (GO:0042832)2.85304639
122cellular response to interferon-beta (GO:0035458)2.84912610
123activated T cell proliferation (GO:0050798)2.84289088
124regulation of T cell mediated cytotoxicity (GO:0001914)2.83011395
125regulation of T-helper 2 cell differentiation (GO:0045628)2.81906582
126regulation of alpha-beta T cell proliferation (GO:0046640)2.81690626
127regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74356222
128leukocyte cell-cell adhesion (GO:0007159)2.73010450
129regulation of T cell tolerance induction (GO:0002664)2.72426973
130negative T cell selection (GO:0043383)2.72289267
131negative regulation of interleukin-17 production (GO:0032700)2.71957230
132adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.71479042
133regulation of leukocyte degranulation (GO:0043300)2.70561982
134positive regulation of toll-like receptor signaling pathway (GO:0034123)2.68732029
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68632410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.38616921
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.04984331
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.73135812
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.46653930
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.42421183
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.09990180
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.97624702
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75036884
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.54446273
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52786017
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.23727880
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12698771
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05520004
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97537222
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85518988
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81357524
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.70076920
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55499202
19RUNX_20019798_ChIP-Seq_JUKART_Human2.51106729
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43014926
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37171751
22* SCL_19346495_ChIP-Seq_HPC-7_Human2.32779272
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32751567
24VDR_21846776_ChIP-Seq_THP-1_Human2.31033704
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29795372
26SPI1_23547873_ChIP-Seq_NB4_Human2.27102289
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26823282
28* MYB_26560356_Chip-Seq_TH2_Human2.16271297
29VDR_24763502_ChIP-Seq_THP-1_Human2.15883004
30MAF_26560356_Chip-Seq_TH1_Human2.13639590
31SPI1_23127762_ChIP-Seq_K562_Human2.12862715
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08213439
33* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.93677651
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.93355493
35MYC_22102868_ChIP-Seq_BL_Human1.90044015
36* MYB_26560356_Chip-Seq_TH1_Human1.88473565
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87399105
38* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84954069
39GATA1_22025678_ChIP-Seq_K562_Human1.82163778
40PU_27001747_Chip-Seq_BMDM_Mouse1.76344812
41TCF7_22412390_ChIP-Seq_EML_Mouse1.76172462
42* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70588392
43VDR_24787735_ChIP-Seq_THP-1_Human1.66004572
44UTX_26944678_Chip-Seq_JUKART_Human1.62176371
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59782409
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56061388
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53226721
48* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51249011
49* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48357817
50GATA3_27048872_Chip-Seq_THYMUS_Human1.47681685
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47190836
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41674280
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36864414
54KDM2B_26808549_Chip-Seq_DND41_Human1.34040522
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32758214
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31077969
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29428422
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28295824
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25138464
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23695367
61GATA3_26560356_Chip-Seq_TH2_Human1.22959612
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.20172811
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.20020985
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18680964
65MAF_26560356_Chip-Seq_TH2_Human1.14147183
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13320299
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12823035
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09173396
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.05764688
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04837078
71* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04317733
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.03056775
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.02503209
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02331497
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02246244
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00755492
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00503377
78STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97950642
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97865302
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97403527
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95767709
82GATA2_19941826_ChIP-Seq_K562_Human0.95500421
83GATA1_19941826_ChIP-Seq_K562_Human0.91160759
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90395959
85EGR1_19032775_ChIP-ChIP_M12_Human0.89753712
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89647891
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86637250
88BCL6_27268052_Chip-Seq_Bcells_Human0.86205542
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82390471
90BCOR_27268052_Chip-Seq_Bcells_Human0.80434071
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75749068
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75722636
93LXR_22292898_ChIP-Seq_THP-1_Human0.75046614
94SMRT_27268052_Chip-Seq_Bcells_Human0.74860277
95* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74766549
96SPI1_20517297_ChIP-Seq_HL60_Human0.74378106
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74284053
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73930593
99STAT1_20625510_ChIP-Seq_HELA_Human0.71609460
100* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71288717
101CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70636140
102* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69828541
103GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67883111
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67789871
105* KDM2B_26808549_Chip-Seq_JURKAT_Human0.66037240
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.65573563
107NCOR1_26117541_ChIP-Seq_K562_Human0.63496157
108TFEB_21752829_ChIP-Seq_HELA_Human0.60781933
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56902363
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.55831088
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.55666330
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53956380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.81506626
2MP0003303_peritoneal_inflammation3.49530935
3MP0003436_decreased_susceptibility_to3.40122244
4MP0005671_abnormal_response_to3.39691174
5MP0006082_CNS_inflammation3.19380601
6MP0005387_immune_system_phenotype3.13352806
7MP0001790_abnormal_immune_system3.13352806
8MP0000685_abnormal_immune_system3.12856277
9* MP0001800_abnormal_humoral_immune3.11387716
10* MP0005000_abnormal_immune_tolerance3.03929983
11MP0002419_abnormal_innate_immunity2.97915193
12MP0002148_abnormal_hypersensitivity_rea2.96889607
13* MP0002452_abnormal_antigen_presenting2.94025289
14MP0005058_abnormal_lysosome_morphology2.87696656
15MP0009785_altered_susceptibility_to2.84914484
16* MP0002723_abnormal_immune_serum2.72621284
17MP0004510_myositis2.71246988
18* MP0005025_abnormal_response_to2.66259434
19* MP0001819_abnormal_immune_cell2.51089493
20* MP0002420_abnormal_adaptive_immunity2.50387016
21MP0003191_abnormal_cellular_cholesterol2.38247093
22MP0003172_abnormal_lysosome_physiology2.28330826
23MP0005464_abnormal_platelet_physiology2.25539336
24MP0003300_gastrointestinal_ulcer2.02610124
25MP0002405_respiratory_system_inflammati1.99546855
26MP0000716_abnormal_immune_system1.96777394
27MP0002398_abnormal_bone_marrow1.94565320
28MP0003724_increased_susceptibility_to1.93776029
29MP0001853_heart_inflammation1.93605184
30MP0002166_altered_tumor_susceptibility1.89602248
31MP0000569_abnormal_digit_pigmentation1.85106544
32MP0001533_abnormal_skeleton_physiology1.83212170
33MP0009840_abnormal_foam_cell1.82436042
34* MP0001845_abnormal_inflammatory_respons1.81609539
35MP0004947_skin_inflammation1.81006231
36MP0005310_abnormal_salivary_gland1.77084151
37MP0000689_abnormal_spleen_morphology1.75235161
38MP0009333_abnormal_splenocyte_physiolog1.62737016
39MP0002006_tumorigenesis1.62695850
40MP0003183_abnormal_peptide_metabolism1.62442813
41MP0005451_abnormal_body_composition1.61815076
42MP0009278_abnormal_bone_marrow1.59415949
43MP0002429_abnormal_blood_cell1.57856518
44* MP0008469_abnormal_protein_level1.57442970
45MP0002722_abnormal_immune_system1.56778088
46* MP0010155_abnormal_intestine_physiology1.49316772
47MP0001873_stomach_inflammation1.48130786
48MP0003763_abnormal_thymus_physiology1.43304202
49MP0003448_altered_tumor_morphology1.39230266
50MP0003075_altered_response_to1.39024765
51MP0008004_abnormal_stomach_pH1.36075371
52MP0000343_altered_response_to1.35811019
53MP0002138_abnormal_hepatobiliary_system1.35546295
54MP0003690_abnormal_glial_cell1.29196546
55MP0002254_reproductive_system_inflammat1.28621131
56MP0002998_abnormal_bone_remodeling1.27371840
57MP0001545_abnormal_hematopoietic_system1.26993570
58MP0005397_hematopoietic_system_phenotyp1.26993570
59MP0002396_abnormal_hematopoietic_system1.25601378
60MP0008260_abnormal_autophagy1.24266916
61MP0009764_decreased_sensitivity_to1.18877380
62MP0001851_eye_inflammation1.18104736
63MP0000465_gastrointestinal_hemorrhage1.16277979
64MP0005174_abnormal_tail_pigmentation1.11156207
65MP0000604_amyloidosis1.10920353
66MP0002933_joint_inflammation1.08469201
67MP0005166_decreased_susceptibility_to1.07763054
68MP0004808_abnormal_hematopoietic_stem1.06406874
69MP0000858_altered_metastatic_potential1.03594873
70MP0000703_abnormal_thymus_morphology1.01946947
71MP0005076_abnormal_cell_differentiation1.00229993
72MP0003566_abnormal_cell_adhesion0.97217014
73MP0003656_abnormal_erythrocyte_physiolo0.93591118
74MP0003828_pulmonary_edema0.92443871
75MP0003866_abnormal_defecation0.91568998
76MP0010307_abnormal_tumor_latency0.90502697
77MP0002332_abnormal_exercise_endurance0.88809405
78MP0000249_abnormal_blood_vessel0.88759662
79MP0003045_fibrosis0.86398374
80MP0009763_increased_sensitivity_to0.85897210
81MP0003091_abnormal_cell_migration0.84549812
82MP0003453_abnormal_keratinocyte_physiol0.84044296
83MP0002928_abnormal_bile_duct0.81907740
84MP0002132_abnormal_respiratory_system0.80667601
85MP0005167_abnormal_blood-brain_barrier0.80294013
86MP0005390_skeleton_phenotype0.79028312
87MP0000767_abnormal_smooth_muscle0.78506114
88MP0000015_abnormal_ear_pigmentation0.77828774
89MP0004381_abnormal_hair_follicle0.77371424
90MP0009765_abnormal_xenobiotic_induced0.73555646
91MP0001915_intracranial_hemorrhage0.71624356
92MP0002136_abnormal_kidney_physiology0.71145788
93MP0004883_abnormal_blood_vessel0.70647498
94MP0006054_spinal_hemorrhage0.66828130
95MP0002277_abnormal_respiratory_mucosa0.65455493
96MP0005164_abnormal_response_to0.64861162
97MP0000371_diluted_coat_color0.64360929
98MP0000490_abnormal_crypts_of0.63586245
99MP0008874_decreased_physiological_sensi0.62969846
100MP0003806_abnormal_nucleotide_metabolis0.62851910
101MP0010352_gastrointestinal_tract_polyps0.61851401
102MP0003795_abnormal_bone_structure0.61801079
103MP0000609_abnormal_liver_physiology0.61638425
104MP0008873_increased_physiological_sensi0.61495633
105MP0005023_abnormal_wound_healing0.60150481
106MP0002139_abnormal_hepatobiliary_system0.59882325
107MP0004130_abnormal_muscle_cell0.56449496
108MP0002693_abnormal_pancreas_physiology0.54652238
109MP0001986_abnormal_taste_sensitivity0.52103607
110MP0001663_abnormal_digestive_system0.51235915
111MP0001501_abnormal_sleep_pattern0.48801491
112MP0005381_digestive/alimentary_phenotyp0.48573207
113MP0005535_abnormal_body_temperature0.48213577
114MP0003279_aneurysm0.47972940
115MP0002019_abnormal_tumor_incidence0.45502648
116MP0000920_abnormal_myelination0.43983614
117MP0000598_abnormal_liver_morphology0.43433704
118MP0002009_preneoplasia0.43235616

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.07691098
2* Recurrent abscess formation (HP:0002722)5.81982580
3Eczematoid dermatitis (HP:0000976)5.57516791
4* Recurrent bacterial skin infections (HP:0005406)5.20868356
5Glomerulonephritis (HP:0000099)4.86226193
6Recurrent gram-negative bacterial infections (HP:0005420)4.52478354
7Abnormality of glycolipid metabolism (HP:0010969)4.39755983
8Abnormality of liposaccharide metabolism (HP:0010968)4.39755983
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.39755983
10Elevated erythrocyte sedimentation rate (HP:0003565)4.21630633
11Myositis (HP:0100614)4.12306791
12Abnormality of macrophages (HP:0004311)4.10661273
13Increased cerebral lipofuscin (HP:0011813)4.05853397
14Recurrent fungal infections (HP:0002841)3.92977425
15Recurrent viral infections (HP:0004429)3.87749122
16Mediastinal lymphadenopathy (HP:0100721)3.86354237
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.67830928
18Gastrointestinal infarctions (HP:0005244)3.61759145
19Orchitis (HP:0100796)3.55276810
20Cellulitis (HP:0100658)3.51567047
21Encephalitis (HP:0002383)3.47473350
22* Recurrent skin infections (HP:0001581)3.45975040
23Keratoconjunctivitis (HP:0001096)3.44286441
24Vasculitis (HP:0002633)3.38155128
25Complement deficiency (HP:0004431)3.37724777
26Vacuolated lymphocytes (HP:0001922)3.36573179
27Dysostosis multiplex (HP:0000943)3.32902012
28Retrobulbar optic neuritis (HP:0100654)3.31832161
29Optic neuritis (HP:0100653)3.31832161
30Obstructive lung disease (HP:0006536)3.21450647
31Chronic obstructive pulmonary disease (HP:0006510)3.21450647
32Gingivitis (HP:0000230)3.15399406
33Autoimmune thrombocytopenia (HP:0001973)3.14673353
34Meningitis (HP:0001287)3.14122470
35Chronic otitis media (HP:0000389)3.10163754
36Stomatitis (HP:0010280)3.08816531
37Agammaglobulinemia (HP:0004432)3.07386950
38Disinhibition (HP:0000734)3.01327687
39Recurrent cutaneous fungal infections (HP:0011370)2.99405325
40Chronic mucocutaneous candidiasis (HP:0002728)2.99405325
41Abnormality of complement system (HP:0005339)2.97718693
42Pustule (HP:0200039)2.93177443
43Spontaneous hematomas (HP:0007420)2.89705579
44Increased IgM level (HP:0003496)2.88537971
45Axonal loss (HP:0003447)2.87307697
46IgM deficiency (HP:0002850)2.86125784
47Nephritis (HP:0000123)2.86061050
48Interstitial pulmonary disease (HP:0006530)2.85570840
49Abnormality of T cells (HP:0002843)2.79533866
50Myocardial infarction (HP:0001658)2.76750757
51Pulmonary infiltrates (HP:0002113)2.73630838
52Recurrent bronchitis (HP:0002837)2.72122060
53Periodontitis (HP:0000704)2.71945286
54Gangrene (HP:0100758)2.70106169
55Osteomyelitis (HP:0002754)2.69894915
56Chest pain (HP:0100749)2.68989945
57Arterial thrombosis (HP:0004420)2.65142591
58Leukocytosis (HP:0001974)2.62410524
59Chronic diarrhea (HP:0002028)2.59797156
60Autoimmune hemolytic anemia (HP:0001890)2.58343502
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57580526
62Basal ganglia calcification (HP:0002135)2.57132924
63Pulmonary embolism (HP:0002204)2.56749293
64* Colitis (HP:0002583)2.55800061
65Urinary glycosaminoglycan excretion (HP:0003541)2.53874630
66Mucopolysacchariduria (HP:0008155)2.53874630
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.51297291
68Amyloidosis (HP:0011034)2.51101525
69Gastrointestinal stroma tumor (HP:0100723)2.50955908
70Nasal polyposis (HP:0100582)2.50405634
71* Inflammation of the large intestine (HP:0002037)2.50133152
72Anorexia (HP:0002039)2.49070551
73Recurrent pneumonia (HP:0006532)2.43044244
74Increased serum ferritin (HP:0003281)2.42800919
75Abnormality of polysaccharide metabolism (HP:0011012)2.42737743
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42737743
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42737743
78Agnosia (HP:0010524)2.41270333
79Eosinophilia (HP:0001880)2.36449114
80Thrombocytosis (HP:0001894)2.35250676
81Loss of speech (HP:0002371)2.33512274
82Cerebral aneurysm (HP:0004944)2.33506609
83Episodic fever (HP:0001954)2.33492822
84Abnormality of the pleura (HP:0002103)2.33369308
85* Gastrointestinal inflammation (HP:0004386)2.32760189
86Joint swelling (HP:0001386)2.32367786
87Gingival bleeding (HP:0000225)2.32165731
88Panhypogammaglobulinemia (HP:0003139)2.31966971
89Polyneuropathy (HP:0001271)2.31759818
90Granulocytopenia (HP:0001913)2.29408388
91Increased IgE level (HP:0003212)2.28208409
92Upper motor neuron abnormality (HP:0002127)2.28174981
93Abnormality of the nasal mucosa (HP:0000433)2.28004356
94Purpura (HP:0000979)2.25749942
95Lymphopenia (HP:0001888)2.23434702
96Petechiae (HP:0000967)2.21021611
97Arterial tortuosity (HP:0005116)2.20765630
98Urticaria (HP:0001025)2.18675163
99Glomerulopathy (HP:0100820)2.18457880
100Emphysema (HP:0002097)2.17432290
101Thick nail (HP:0001805)2.15341466
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.15026738
103Recurrent lower respiratory tract infections (HP:0002783)2.14970528
104Vertigo (HP:0002321)2.13590215
105Thyroiditis (HP:0100646)2.12663340
106Abnormality of T cell number (HP:0011839)2.11639349
107Epistaxis (HP:0000421)2.10887810
108Hypergammaglobulinemia (HP:0010702)2.10768662
109Prolonged bleeding time (HP:0003010)2.09919461
110Prostate neoplasm (HP:0100787)2.09798318
111Hepatosplenomegaly (HP:0001433)2.08517832
112T lymphocytopenia (HP:0005403)2.07499464
113Abnormality of iron homeostasis (HP:0011031)2.06275230
114Hemoptysis (HP:0002105)2.04694310
115Impaired platelet aggregation (HP:0003540)2.04056893
116Abnormal platelet function (HP:0011869)2.04056893
117Keratoconjunctivitis sicca (HP:0001097)2.03822845
118Osteolytic defects of the hand bones (HP:0009699)2.02639421
119Osteolytic defects of the phalanges of the hand (HP:0009771)2.02639421
120Recurrent sinusitis (HP:0011108)2.01413472
121Fatigue (HP:0012378)2.01276569
122Severe combined immunodeficiency (HP:0004430)2.00896766
123Acne (HP:0001061)2.00156147
124Amaurosis fugax (HP:0100576)2.00093964
125Restrictive lung disease (HP:0002091)1.98830271
126Arthralgia (HP:0002829)1.98661107
127Abnormality of T cell physiology (HP:0011840)1.98178382
128Slow saccadic eye movements (HP:0000514)1.97972527
129Mutism (HP:0002300)1.97400515
130IgG deficiency (HP:0004315)1.97298729
131Abnormality of eosinophils (HP:0001879)1.97082949
132Abnormality of the endocardium (HP:0004306)1.97005745
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96626721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.80913571
2TGFBR23.59390192
3MAP3K143.42649758
4BLK3.29849063
5PRPF4B3.24773862
6RIPK43.18218447
7IRAK42.98648599
8* TYK22.94557141
9TBK12.93731149
10IRAK32.82129042
11CSF1R2.78149029
12ERN12.30083062
13IKBKB2.24267797
14IKBKE2.23432625
15KIT2.22236570
16JAK32.19737752
17STK102.08733105
18TXK2.02956745
19CSK1.86143935
20ZAP701.82802020
21MAP3K131.81400758
22* JAK11.78934372
23SYK1.65162810
24GRK71.61158820
25CDK121.57642839
26MAPK151.57299097
27HCK1.53880581
28MAP3K101.49543465
29TNK21.49359750
30BTK1.44686533
31FES1.39042635
32TAOK11.33975118
33EPHB11.33196699
34CHUK1.32744066
35TAOK21.32698004
36LCK1.32609160
37MAP3K111.31785991
38SIK21.29252469
39MATK1.26411096
40JAK21.24761782
41NEK91.23838841
42ITK1.23820701
43LYN1.23761410
44CDC42BPA1.14342769
45CLK11.13523886
46CAMK1D1.10707820
47MAP3K11.07696124
48GRK61.06638836
49FGR1.06138574
50FGFR41.04675126
51MARK31.02271512
52PIM11.00892573
53TEC1.00265714
54TAOK30.99989152
55FGFR30.99474052
56CAMKK20.97646975
57RPS6KA40.97595522
58MAP2K30.97551677
59LRRK20.93922935
60TESK20.80812565
61TRIB30.75441338
62CDK60.72200285
63MARK20.72066151
64CAMK1G0.71817403
65PTK60.70896981
66MST40.70250055
67PAK40.68793826
68CAMKK10.63032487
69PKN20.60731916
70NLK0.60115849
71PIM20.58934827
72PDK10.58931440
73STK40.57786591
74PRKCQ0.56600699
75MAPKAPK20.56485733
76KSR20.56272261
77TYRO30.55396248
78EGFR0.55119194
79MAP3K50.53196582
80BMPR20.52980808
81NME20.52732772
82FLT30.51102814
83MAPK120.51003668
84ABL10.49753555
85TTN0.49105150
86IRAK10.48376396
87PKN10.47119164
88EEF2K0.46496991
89MOS0.45087586
90MAP2K60.43990905
91DDR20.43592052
92CDK90.43255145
93SIK30.43242262
94MAP3K30.43070031
95MAPK70.42107299
96DYRK1B0.41755087
97PRKCD0.41718484
98EPHA30.40664064
99PRKD20.40336398
100PIK3CG0.40281080
101SGK30.38139075
102RPS6KA60.37649176
103FYN0.36142005
104HIPK20.36055974
105TRPM70.35314346
106INSR0.34720426
107IRAK20.34405658
108PDPK10.33851812
109IGF1R0.33155680
110SCYL20.32542706
111SIK10.32174894
112EIF2AK20.31528462
113MAP2K20.31351189
114MAPK40.31281038
115MAP3K70.31131347
116MAP3K80.30333711
117MAPK110.29791037
118RIPK10.29157552
119YES10.27581425
120ADRBK20.26638019
121RPS6KC10.26541128
122RPS6KL10.26541128
123MELK0.25226324
124PDGFRB0.25128768
125PRKAA20.24840022
126CDK40.23612818

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.46281930
2Leishmaniasis_Homo sapiens_hsa051403.16816998
3Osteoclast differentiation_Homo sapiens_hsa043802.91435795
4B cell receptor signaling pathway_Homo sapiens_hsa046622.82319559
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.55301188
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45224645
7Other glycan degradation_Homo sapiens_hsa005112.43838464
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.28585004
9Pertussis_Homo sapiens_hsa051332.16704221
10Measles_Homo sapiens_hsa051622.13222635
11Primary immunodeficiency_Homo sapiens_hsa053402.10730777
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.06165201
13Antigen processing and presentation_Homo sapiens_hsa046122.05447334
14Lysosome_Homo sapiens_hsa041422.00097915
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98512621
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92867105
17* Tuberculosis_Homo sapiens_hsa051521.90536371
18Graft-versus-host disease_Homo sapiens_hsa053321.89825863
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85113903
20Allograft rejection_Homo sapiens_hsa053301.80088356
21Legionellosis_Homo sapiens_hsa051341.78026046
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76999852
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.76647507
24Hematopoietic cell lineage_Homo sapiens_hsa046401.71090150
25* Toxoplasmosis_Homo sapiens_hsa051451.69171060
26Influenza A_Homo sapiens_hsa051641.67152360
27Chemokine signaling pathway_Homo sapiens_hsa040621.65351578
28Malaria_Homo sapiens_hsa051441.65091219
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62776533
30TNF signaling pathway_Homo sapiens_hsa046681.54691601
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46768729
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45839332
33Herpes simplex infection_Homo sapiens_hsa051681.45444357
34Apoptosis_Homo sapiens_hsa042101.44752633
35T cell receptor signaling pathway_Homo sapiens_hsa046601.43025449
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41589281
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28007100
38* Jak-STAT signaling pathway_Homo sapiens_hsa046301.26994643
39Shigellosis_Homo sapiens_hsa051311.25268994
40Rheumatoid arthritis_Homo sapiens_hsa053231.24839388
41Asthma_Homo sapiens_hsa053101.24405916
42Salmonella infection_Homo sapiens_hsa051321.22333191
43* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18686024
44Viral myocarditis_Homo sapiens_hsa054161.17355499
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.15753567
46Hepatitis B_Homo sapiens_hsa051611.15439422
47Phagosome_Homo sapiens_hsa041451.09232202
48Chronic myeloid leukemia_Homo sapiens_hsa052201.06588694
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01531574
50Pancreatic cancer_Homo sapiens_hsa052121.00343793
51African trypanosomiasis_Homo sapiens_hsa051430.99486942
52Acute myeloid leukemia_Homo sapiens_hsa052210.99227805
53Platelet activation_Homo sapiens_hsa046110.95065278
54Hepatitis C_Homo sapiens_hsa051600.91150973
55Autoimmune thyroid disease_Homo sapiens_hsa053200.90264104
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.88543883
57Complement and coagulation cascades_Homo sapiens_hsa046100.87309585
58Prion diseases_Homo sapiens_hsa050200.86382764
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83186536
60Type I diabetes mellitus_Homo sapiens_hsa049400.80376300
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79493539
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78277435
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75260508
64* Epstein-Barr virus infection_Homo sapiens_hsa051690.69714494
65Prolactin signaling pathway_Homo sapiens_hsa049170.66566873
66Endocytosis_Homo sapiens_hsa041440.58037542
67Viral carcinogenesis_Homo sapiens_hsa052030.57315405
68Amoebiasis_Homo sapiens_hsa051460.55523858
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54245147
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.52785852
71VEGF signaling pathway_Homo sapiens_hsa043700.51386270
72Notch signaling pathway_Homo sapiens_hsa043300.50768375
73Small cell lung cancer_Homo sapiens_hsa052220.49698580
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49296285
75Colorectal cancer_Homo sapiens_hsa052100.48871985
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.48596269
77Caffeine metabolism_Homo sapiens_hsa002320.48361387
78HTLV-I infection_Homo sapiens_hsa051660.48308567
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47474705
80Non-small cell lung cancer_Homo sapiens_hsa052230.44571114
81Renal cell carcinoma_Homo sapiens_hsa052110.44104259
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43982228
83GnRH signaling pathway_Homo sapiens_hsa049120.42917498
84MAPK signaling pathway_Homo sapiens_hsa040100.41627516
85Insulin resistance_Homo sapiens_hsa049310.41425811
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38575621
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38284225
88Type II diabetes mellitus_Homo sapiens_hsa049300.38055311
89FoxO signaling pathway_Homo sapiens_hsa040680.36533057
90HIF-1 signaling pathway_Homo sapiens_hsa040660.35915207
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35778504
92Inositol phosphate metabolism_Homo sapiens_hsa005620.35651509
93Choline metabolism in cancer_Homo sapiens_hsa052310.34911185
94Endometrial cancer_Homo sapiens_hsa052130.31544070
95ABC transporters_Homo sapiens_hsa020100.29328240
96Proteoglycans in cancer_Homo sapiens_hsa052050.28270082
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.27251181
98Bladder cancer_Homo sapiens_hsa052190.27206539
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26524496
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26186519
101MicroRNAs in cancer_Homo sapiens_hsa052060.24545626
102Dorso-ventral axis formation_Homo sapiens_hsa043200.24191655
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23713260
104Prostate cancer_Homo sapiens_hsa052150.23121554
105Renin-angiotensin system_Homo sapiens_hsa046140.22758845
106ErbB signaling pathway_Homo sapiens_hsa040120.22413346
107Systemic lupus erythematosus_Homo sapiens_hsa053220.22204913
108mTOR signaling pathway_Homo sapiens_hsa041500.21766176
109Collecting duct acid secretion_Homo sapiens_hsa049660.19924214
110Adherens junction_Homo sapiens_hsa045200.19732253
111Rap1 signaling pathway_Homo sapiens_hsa040150.18944562

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