IL10RB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.80297803
2modulation by symbiont of host defense response (GO:0052031)5.47240975
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.47240975
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.47240975
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.47240975
6modulation by symbiont of host immune response (GO:0052553)5.47240975
7positive regulation by symbiont of host defense response (GO:0052509)5.47240975
8regulation of interferon-beta biosynthetic process (GO:0045357)4.92299149
9neutrophil activation involved in immune response (GO:0002283)4.65850039
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53366295
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.53366295
12antigen processing and presentation of endogenous antigen (GO:0019883)4.30915782
13positive regulation of interferon-alpha production (GO:0032727)4.27293756
14positive regulation of gamma-delta T cell activation (GO:0046645)4.18372536
15macrophage activation involved in immune response (GO:0002281)4.15705613
16regulation of B cell receptor signaling pathway (GO:0050855)4.13043009
17immunoglobulin mediated immune response (GO:0016064)4.10942269
18response to peptidoglycan (GO:0032494)4.07575947
19regulation of interferon-alpha production (GO:0032647)4.06701157
20positive regulation of antigen processing and presentation (GO:0002579)3.95512412
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.75844518
22response to host immune response (GO:0052572)3.70690564
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70690564
24microglial cell activation (GO:0001774)3.53250337
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.52001757
26respiratory burst (GO:0045730)3.47399677
27pinocytosis (GO:0006907)3.45617477
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38113423
29regulation of antigen processing and presentation (GO:0002577)3.37348019
30response to host (GO:0075136)3.36368534
31response to host defenses (GO:0052200)3.36368534
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36368534
33neutrophil activation (GO:0042119)3.35180743
34positive regulation of B cell differentiation (GO:0045579)3.29744486
35myeloid cell activation involved in immune response (GO:0002275)3.28895760
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26881064
37response to type I interferon (GO:0034340)3.26504721
38response to muramyl dipeptide (GO:0032495)3.25330250
39macrophage activation (GO:0042116)3.24580351
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.24069311
41cellular response to type I interferon (GO:0071357)3.23849877
42type I interferon signaling pathway (GO:0060337)3.23849877
43granulocyte activation (GO:0036230)3.23759491
44cellular extravasation (GO:0045123)3.22247650
45detection of other organism (GO:0098543)3.17900681
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13668243
47regulation of T cell tolerance induction (GO:0002664)3.11927641
48interferon-gamma-mediated signaling pathway (GO:0060333)3.09215870
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.06092234
50cellular response to zinc ion (GO:0071294)3.03860697
51regulation of tolerance induction (GO:0002643)3.03092149
52response to interferon-alpha (GO:0035455)3.00588712
53Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00476695
54production of molecular mediator involved in inflammatory response (GO:0002532)2.99205200
55negative regulation of leukocyte mediated immunity (GO:0002704)2.98858650
56regulation of myeloid leukocyte mediated immunity (GO:0002886)2.98788643
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98619433
58B cell mediated immunity (GO:0019724)2.97406569
59detection of molecule of bacterial origin (GO:0032490)2.96863016
60defense response to protozoan (GO:0042832)2.96309938
61positive regulation of interferon-beta production (GO:0032728)2.95307572
62positive regulation of mast cell degranulation (GO:0043306)2.95242791
63positive regulation of mast cell activation involved in immune response (GO:0033008)2.95242791
64negative regulation of T cell mediated immunity (GO:0002710)2.95031451
65response to interferon-beta (GO:0035456)2.94883479
66regulation of leukocyte degranulation (GO:0043300)2.93174571
67leukocyte aggregation (GO:0070486)2.92956300
68regulation of B cell differentiation (GO:0045577)2.88315084
69regulation of T cell mediated cytotoxicity (GO:0001914)2.85422887
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85364897
71response to protozoan (GO:0001562)2.83730620
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81325498
73negative regulation of cell killing (GO:0031342)2.81325498
74regulation of mast cell activation (GO:0033003)2.80345557
75regulation of gamma-delta T cell activation (GO:0046643)2.80242013
76regulation of interleukin-8 biosynthetic process (GO:0045414)2.80011899
77detection of external biotic stimulus (GO:0098581)2.78756158
78monocyte chemotaxis (GO:0002548)2.78573328
79response to interleukin-15 (GO:0070672)2.76836230
80negative regulation of cytokine production involved in immune response (GO:0002719)2.76828618
81negative regulation of interleukin-17 production (GO:0032700)2.76492324
82regulation of gamma-delta T cell differentiation (GO:0045586)2.76305356
83myeloid dendritic cell activation (GO:0001773)2.76266156
84myeloid leukocyte activation (GO:0002274)2.74719932
85regulation of mast cell degranulation (GO:0043304)2.74338683
86leukocyte migration involved in inflammatory response (GO:0002523)2.73953605
87regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.73943540
88regulation of T-helper 2 cell differentiation (GO:0045628)2.73901504
89negative regulation of innate immune response (GO:0045824)2.73874853
90neutrophil mediated immunity (GO:0002446)2.73348450
91negative regulation of interleukin-12 production (GO:0032695)2.73119730
92antigen processing and presentation via MHC class Ib (GO:0002475)2.71650831
93I-kappaB phosphorylation (GO:0007252)2.70815757
94positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70740059
95cellular response to interferon-beta (GO:0035458)2.70520070
96positive regulation of macrophage differentiation (GO:0045651)2.70201280
97myeloid dendritic cell differentiation (GO:0043011)2.70127676
98positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69340248
99negative regulation of interleukin-6 production (GO:0032715)2.68158286
100cellular response to interferon-gamma (GO:0071346)2.66846614
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65998824
102positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.65947636
103B cell receptor signaling pathway (GO:0050853)2.65904134
104positive regulation of chemokine biosynthetic process (GO:0045080)2.65821122
105positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65337567
106positive regulation of mast cell activation (GO:0033005)2.64893620
107cellular response to interleukin-15 (GO:0071350)2.64520716
108NIK/NF-kappaB signaling (GO:0038061)2.62644260
109germinal center formation (GO:0002467)2.62613114
110positive regulation of type 2 immune response (GO:0002830)2.62373265
111leukocyte degranulation (GO:0043299)2.60221613
112response to interferon-gamma (GO:0034341)2.59932071
113regulation of alpha-beta T cell proliferation (GO:0046640)2.59712550
114mast cell activation (GO:0045576)2.59611233
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59588264
116negative regulation of mast cell activation (GO:0033004)2.58838803
117detection of bacterium (GO:0016045)2.58725278
118dendritic cell differentiation (GO:0097028)2.58322583
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57867334
120superoxide anion generation (GO:0042554)2.57077037
121detection of biotic stimulus (GO:0009595)2.56205333
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54945973
123leukocyte cell-cell adhesion (GO:0007159)2.54035505
124positive regulation of cellular amide metabolic process (GO:0034250)2.53584619
125regulation of mast cell activation involved in immune response (GO:0033006)2.53385219
126T-helper 1 type immune response (GO:0042088)2.53253430
127T cell migration (GO:0072678)2.53021314
128regulation of mononuclear cell migration (GO:0071675)2.52804535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.65523724
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.36770841
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.07916291
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.83767179
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75106665
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.69404506
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69158125
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55751127
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53455318
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39809298
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37902091
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.05163436
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88940028
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58893097
15SCL_19346495_ChIP-Seq_HPC-7_Human2.55043243
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54033422
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46861933
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45609728
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43481545
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33461693
21SPI1_23547873_ChIP-Seq_NB4_Human2.21956332
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21585517
23RUNX_20019798_ChIP-Seq_JUKART_Human2.19297633
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.12117805
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11182607
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.99398473
27MYB_26560356_Chip-Seq_TH2_Human1.98285103
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.94559500
29VDR_24763502_ChIP-Seq_THP-1_Human1.94497888
30SPI1_23127762_ChIP-Seq_K562_Human1.93898758
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.91693060
32MAF_26560356_Chip-Seq_TH1_Human1.82976587
33* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82844373
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82132850
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82013150
36* VDR_21846776_ChIP-Seq_THP-1_Human1.77588538
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74462859
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72665568
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72047569
40PU_27001747_Chip-Seq_BMDM_Mouse1.67550975
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66437807
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62972139
43MYB_26560356_Chip-Seq_TH1_Human1.62725205
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58971968
45GATA1_22025678_ChIP-Seq_K562_Human1.58304779
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54313145
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53499471
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52044351
49* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51321698
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49396954
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48086139
52VDR_24787735_ChIP-Seq_THP-1_Human1.47889314
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45423919
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42673895
55* UTX_26944678_Chip-Seq_JUKART_Human1.40235630
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39112418
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33382859
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.30687527
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30146523
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28144406
61GATA3_27048872_Chip-Seq_THYMUS_Human1.27891499
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27279897
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26279066
64TCF7_22412390_ChIP-Seq_EML_Mouse1.25554155
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24197032
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23743117
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21839427
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.19524462
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18298719
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12402304
71GATA3_26560356_Chip-Seq_TH2_Human1.12394986
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.12226336
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11078746
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10161248
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09739649
76GATA2_19941826_ChIP-Seq_K562_Human1.08320718
77GATA1_19941826_ChIP-Seq_K562_Human1.07556085
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07465832
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07178294
80BCL6_27268052_Chip-Seq_Bcells_Human1.06705582
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05822841
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05442429
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.03525790
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01121597
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01111778
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.00495728
87MYC_22102868_ChIP-Seq_BL_Human0.99904928
88MAF_26560356_Chip-Seq_TH2_Human0.99751954
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99166747
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97034177
91LXR_22292898_ChIP-Seq_THP-1_Human0.96805766
92STAT1_20625510_ChIP-Seq_HELA_Human0.96304904
93BCOR_27268052_Chip-Seq_Bcells_Human0.94225278
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92197165
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89193066
96SOX2_20726797_ChIP-Seq_SW620_Human0.89079322
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88717545
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86721725
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85786851
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85786851
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85750889
102TFEB_21752829_ChIP-Seq_HELA_Human0.84805495
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84786331
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84690664
105PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84394652
106LXR_22158963_ChIP-Seq_LIVER_Mouse0.84279582
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84260367
108EGR1_19032775_ChIP-ChIP_M12_Human0.83818844
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83565550
110SPI1_20517297_ChIP-Seq_HL60_Human0.82547525
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.82280207
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80721604
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80503941
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78045191
115SMRT_27268052_Chip-Seq_Bcells_Human0.77373924
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.77147523
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77014884
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76736026
119* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76723600
120KDM2B_26808549_Chip-Seq_DND41_Human0.75715607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.92392855
2MP0009785_altered_susceptibility_to3.11523455
3MP0003436_decreased_susceptibility_to3.01914467
4MP0005058_abnormal_lysosome_morphology2.97946747
5MP0003724_increased_susceptibility_to2.78253948
6MP0002419_abnormal_innate_immunity2.77014660
7MP0002148_abnormal_hypersensitivity_rea2.76854264
8MP0003191_abnormal_cellular_cholesterol2.67131913
9MP0005000_abnormal_immune_tolerance2.61402301
10MP0003303_peritoneal_inflammation2.60779695
11MP0005025_abnormal_response_to2.56172226
12MP0006082_CNS_inflammation2.54766100
13MP0005671_abnormal_response_to2.52377421
14MP0002452_abnormal_antigen_presenting2.39441200
15MP0001790_abnormal_immune_system2.37289382
16MP0005387_immune_system_phenotype2.37289382
17MP0000685_abnormal_immune_system2.31362241
18MP0001800_abnormal_humoral_immune2.28714806
19* MP0002723_abnormal_immune_serum2.15543857
20MP0005464_abnormal_platelet_physiology2.13270178
21MP0004510_myositis2.10388080
22MP0001819_abnormal_immune_cell2.08633651
23MP0002420_abnormal_adaptive_immunity2.08121828
24MP0009278_abnormal_bone_marrow2.00043768
25MP0000343_altered_response_to1.99292404
26MP0003828_pulmonary_edema1.89263882
27MP0003300_gastrointestinal_ulcer1.85618253
28MP0003172_abnormal_lysosome_physiology1.85371845
29* MP0002405_respiratory_system_inflammati1.82297522
30MP0001533_abnormal_skeleton_physiology1.78913548
31MP0001853_heart_inflammation1.78252770
32MP0002166_altered_tumor_susceptibility1.73672384
33* MP0001845_abnormal_inflammatory_respons1.67722857
34MP0005397_hematopoietic_system_phenotyp1.65891551
35MP0001545_abnormal_hematopoietic_system1.65891551
36MP0003806_abnormal_nucleotide_metabolis1.63559244
37* MP0010155_abnormal_intestine_physiology1.62123918
38MP0002139_abnormal_hepatobiliary_system1.61677946
39MP0001873_stomach_inflammation1.61535172
40MP0004947_skin_inflammation1.59915462
41MP0009333_abnormal_splenocyte_physiolog1.57358725
42MP0009840_abnormal_foam_cell1.55520159
43* MP0000716_abnormal_immune_system1.52246996
44MP0002006_tumorigenesis1.51294622
45MP0002398_abnormal_bone_marrow1.49402382
46MP0008260_abnormal_autophagy1.49053380
47* MP0008469_abnormal_protein_level1.48305994
48MP0005451_abnormal_body_composition1.45323817
49MP0005167_abnormal_blood-brain_barrier1.44070470
50MP0009764_decreased_sensitivity_to1.40583638
51* MP0000689_abnormal_spleen_morphology1.35103029
52MP0003448_altered_tumor_morphology1.33050293
53* MP0002429_abnormal_blood_cell1.29611660
54MP0002396_abnormal_hematopoietic_system1.27395870
55MP0002998_abnormal_bone_remodeling1.26056038
56MP0000858_altered_metastatic_potential1.23020381
57MP0005174_abnormal_tail_pigmentation1.22758399
58* MP0002722_abnormal_immune_system1.22193540
59MP0003763_abnormal_thymus_physiology1.21269474
60MP0000465_gastrointestinal_hemorrhage1.21150172
61MP0002132_abnormal_respiratory_system1.19807088
62MP0003183_abnormal_peptide_metabolism1.18150483
63MP0003075_altered_response_to1.17122152
64MP0002138_abnormal_hepatobiliary_system1.16451996
65MP0004147_increased_porphyrin_level1.16233224
66MP0004883_abnormal_blood_vessel1.15942576
67MP0005310_abnormal_salivary_gland1.15425696
68MP0001879_abnormal_lymphatic_vessel1.12428836
69MP0003566_abnormal_cell_adhesion1.11545786
70MP0004808_abnormal_hematopoietic_stem1.08092306
71MP0003279_aneurysm1.06159312
72MP0004782_abnormal_surfactant_physiolog1.04910274
73MP0005166_decreased_susceptibility_to1.02109507
74MP0002277_abnormal_respiratory_mucosa1.01038139
75MP0008004_abnormal_stomach_pH1.00470701
76MP0000249_abnormal_blood_vessel0.99767039
77MP0004084_abnormal_cardiac_muscle0.99416672
78MP0002933_joint_inflammation0.98637358
79MP0005365_abnormal_bile_salt0.97730530
80MP0001958_emphysema0.96480034
81MP0006054_spinal_hemorrhage0.96452514
82MP0010368_abnormal_lymphatic_system0.95632411
83MP0000767_abnormal_smooth_muscle0.92567985
84MP0000015_abnormal_ear_pigmentation0.92070758
85MP0008438_abnormal_cutaneous_collagen0.91050703
86MP0005165_increased_susceptibility_to0.90569175
87MP0000371_diluted_coat_color0.90489278
88MP0003690_abnormal_glial_cell0.89781683
89MP0000569_abnormal_digit_pigmentation0.88648107
90MP0004130_abnormal_muscle_cell0.86962751
91MP0009763_increased_sensitivity_to0.86773587
92MP0003656_abnormal_erythrocyte_physiolo0.86049877
93MP0003866_abnormal_defecation0.84310654
94* MP0000490_abnormal_crypts_of0.82173753
95MP0002254_reproductive_system_inflammat0.80811911
96MP0003186_abnormal_redox_activity0.79771854
97MP0001851_eye_inflammation0.79329093
98MP0005390_skeleton_phenotype0.79079962
99MP0005360_urolithiasis0.78698790
100MP0005085_abnormal_gallbladder_physiolo0.78192285
101MP0005164_abnormal_response_to0.78155462
102MP0002136_abnormal_kidney_physiology0.76294916
103MP0001663_abnormal_digestive_system0.75006876
104MP0003045_fibrosis0.74768277
105MP0005319_abnormal_enzyme/_coenzyme0.74550370
106MP0003646_muscle_fatigue0.73019634
107MP0000604_amyloidosis0.72866763
108MP0005023_abnormal_wound_healing0.72855855
109MP0005385_cardiovascular_system_phenoty0.72120345
110MP0001544_abnormal_cardiovascular_syste0.72120345
111MP0009765_abnormal_xenobiotic_induced0.70327151
112MP0003091_abnormal_cell_migration0.69789112
113MP0010630_abnormal_cardiac_muscle0.69630127
114MP0004381_abnormal_hair_follicle0.69522457
115MP0003795_abnormal_bone_structure0.69043051
116MP0000703_abnormal_thymus_morphology0.68834283
117MP0005075_abnormal_melanosome_morpholog0.66542080
118* MP0000609_abnormal_liver_physiology0.64278281
119MP0003195_calcinosis0.63605997
120MP0003252_abnormal_bile_duct0.60537293
121MP0001542_abnormal_bone_strength0.59759517
122MP0002332_abnormal_exercise_endurance0.58145501
123MP0008874_decreased_physiological_sensi0.56785238
124MP0005584_abnormal_enzyme/coenzyme_acti0.55597339
125MP0003453_abnormal_keratinocyte_physiol0.55385188

Predicted human phenotypes

RankGene SetZ-score
1* Recurrent abscess formation (HP:0002722)5.87872293
2Eczematoid dermatitis (HP:0000976)5.59297939
3Recurrent bacterial skin infections (HP:0005406)5.28234567
4Vacuolated lymphocytes (HP:0001922)4.53586226
5Increased cerebral lipofuscin (HP:0011813)4.36832865
6Abnormality of macrophages (HP:0004311)4.35368098
7Elevated erythrocyte sedimentation rate (HP:0003565)4.20189561
8Myositis (HP:0100614)4.09573196
9Recurrent gram-negative bacterial infections (HP:0005420)4.07202018
10Systemic lupus erythematosus (HP:0002725)4.06771392
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.05925185
12Mediastinal lymphadenopathy (HP:0100721)3.64633456
13Pustule (HP:0200039)3.50313819
14Orchitis (HP:0100796)3.44335960
15Dysostosis multiplex (HP:0000943)3.42255013
16Gastrointestinal infarctions (HP:0005244)3.36131498
17Autoimmune thrombocytopenia (HP:0001973)3.33458065
18Chronic otitis media (HP:0000389)3.30641121
19Recurrent skin infections (HP:0001581)3.24962004
20Hematochezia (HP:0002573)3.23725921
21Spontaneous hematomas (HP:0007420)3.23635709
22Recurrent fungal infections (HP:0002841)3.22008337
23Interstitial pulmonary disease (HP:0006530)3.17536328
24Axonal loss (HP:0003447)3.16031640
25Gingivitis (HP:0000230)3.14702153
26Retrobulbar optic neuritis (HP:0100654)3.11062462
27Optic neuritis (HP:0100653)3.11062462
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.08228925
29Encephalitis (HP:0002383)3.04297372
30Obstructive lung disease (HP:0006536)3.02689261
31Chronic obstructive pulmonary disease (HP:0006510)3.02689261
32Petechiae (HP:0000967)2.90904313
33T lymphocytopenia (HP:0005403)2.88019714
34Recurrent viral infections (HP:0004429)2.84600899
35Abnormality of liposaccharide metabolism (HP:0010968)2.83080758
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.83080758
37Abnormality of glycolipid metabolism (HP:0010969)2.83080758
38Glomerulonephritis (HP:0000099)2.82235514
39Stomatitis (HP:0010280)2.79104361
40Abnormality of the nasal mucosa (HP:0000433)2.78157661
41Urinary glycosaminoglycan excretion (HP:0003541)2.77239487
42Mucopolysacchariduria (HP:0008155)2.77239487
43Abnormality of T cell number (HP:0011839)2.76767674
44Amyloidosis (HP:0011034)2.72123118
45Asymmetric septal hypertrophy (HP:0001670)2.71625110
46Vasculitis (HP:0002633)2.68979665
47Periodontitis (HP:0000704)2.66058294
48Purpura (HP:0000979)2.62271034
49Abnormality of polysaccharide metabolism (HP:0011012)2.61126537
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61126537
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61126537
52Cellulitis (HP:0100658)2.60156741
53Pulmonary infiltrates (HP:0002113)2.56229450
54Meningitis (HP:0001287)2.54988494
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53766360
56Basal ganglia calcification (HP:0002135)2.48921099
57Increased IgM level (HP:0003496)2.45205710
58Prostate neoplasm (HP:0100787)2.45062913
59Osteomyelitis (HP:0002754)2.44261360
60Nasal polyposis (HP:0100582)2.43961499
61Pulmonary embolism (HP:0002204)2.42648355
62Chest pain (HP:0100749)2.40976483
63Episodic fever (HP:0001954)2.38868801
64Urticaria (HP:0001025)2.37705973
65Abnormality of T cells (HP:0002843)2.37434764
66Malnutrition (HP:0004395)2.36745374
67Myocardial infarction (HP:0001658)2.36462594
68Arterial thrombosis (HP:0004420)2.36077123
69Thick nail (HP:0001805)2.34502236
70Nephritis (HP:0000123)2.33836514
71Loss of speech (HP:0002371)2.33746794
72Anorexia (HP:0002039)2.32885443
73Thrombocytosis (HP:0001894)2.32107819
74Hemoptysis (HP:0002105)2.30773990
75IgM deficiency (HP:0002850)2.29791434
76Chronic mucocutaneous candidiasis (HP:0002728)2.28823635
77Recurrent cutaneous fungal infections (HP:0011370)2.28823635
78Gangrene (HP:0100758)2.25065608
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.19265419
80Osteolytic defects of the hand bones (HP:0009699)2.19265419
81Disinhibition (HP:0000734)2.18636276
82Prolonged bleeding time (HP:0003010)2.17897610
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16968837
84Abnormality of the pleura (HP:0002103)2.16954399
85Nausea (HP:0002018)2.15106168
86Granulocytopenia (HP:0001913)2.14812427
87Ventricular tachycardia (HP:0004756)2.14662660
88Recurrent bronchitis (HP:0002837)2.12682176
89Hepatosplenomegaly (HP:0001433)2.12592608
90Peritonitis (HP:0002586)2.11800990
91Panhypogammaglobulinemia (HP:0003139)2.11721233
92Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10985715
93Abnormality of T cell physiology (HP:0011840)2.10464725
94Epistaxis (HP:0000421)2.09367130
95Leukocytosis (HP:0001974)2.08856065
96Gastrointestinal stroma tumor (HP:0100723)2.07434533
97Polyneuropathy (HP:0001271)2.06828116
98Esophageal neoplasm (HP:0100751)2.05686118
99Neoplasm of head and neck (HP:0012288)2.05686118
100Abnormality of the prostate (HP:0008775)2.00537624
101Keratoconjunctivitis sicca (HP:0001097)1.99019080
102Impaired platelet aggregation (HP:0003540)1.98530474
103Abnormal platelet function (HP:0011869)1.98530474
104Progressive neurologic deterioration (HP:0002344)1.97593643
105Glomerulopathy (HP:0100820)1.97188108
106Facial diplegia (HP:0001349)1.96357367
107Eosinophilia (HP:0001880)1.95363814
108Increased CSF protein (HP:0002922)1.94476822
109* Inflammation of the large intestine (HP:0002037)1.94400589
110Recurrent pneumonia (HP:0006532)1.93659883
111Premature loss of primary teeth (HP:0006323)1.93400941
112Thoracic kyphosis (HP:0002942)1.93003429
113Autoimmune hemolytic anemia (HP:0001890)1.91150494
114Increased serum ferritin (HP:0003281)1.90019236
115Abnormality of transition element cation homeostasis (HP:0011030)1.89459261
116Skin ulcer (HP:0200042)1.89329408
117Emphysema (HP:0002097)1.89261183
118Abnormality of the pericardium (HP:0001697)1.88783658
119Mucosal telangiectasiae (HP:0100579)1.87905582
120* Gastrointestinal inflammation (HP:0004386)1.86454631
121Acne (HP:0001061)1.85068651
122Hypochromic microcytic anemia (HP:0004840)1.84951809
123Esophageal varix (HP:0002040)1.84554432
124Increased IgE level (HP:0003212)1.83227973
125Chronic diarrhea (HP:0002028)1.80552390
126Keratoconjunctivitis (HP:0001096)1.80220849
127Hypergammaglobulinemia (HP:0010702)1.79798630
128Gingival bleeding (HP:0000225)1.78855735
129Abnormality of iron homeostasis (HP:0011031)1.78476524
130Tetraparesis (HP:0002273)1.78316681
131Albinism (HP:0001022)1.77231304
132Bone pain (HP:0002653)1.76767181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.34081005
2TBK13.14901828
3MAP4K13.08651995
4TGFBR23.05024430
5TYK23.03310074
6KIT3.00440799
7MAP3K142.94605329
8IRAK42.59212360
9IRAK32.39818167
10IKBKE2.35951525
11TXK2.28071554
12RIPK42.27045209
13JAK31.97020371
14TEC1.94339877
15ZAP701.94140863
16ERN11.93160215
17KDR1.81977099
18TTN1.79929611
19NME21.79891741
20JAK11.79068519
21IKBKB1.73047264
22CSF1R1.72560764
23BMPR21.68232422
24TNK21.62806389
25BTK1.60290370
26ACVR1B1.60069709
27PRPF4B1.59600575
28FLT31.56124473
29MAP2K31.55035436
30TAOK11.52005601
31ITK1.47796696
32CSK1.45932762
33NEK91.44345857
34PKN21.41799476
35STK101.41094323
36EPHB11.38216718
37MYLK1.38082390
38SYK1.33290626
39TAOK21.27988991
40TIE11.27831773
41PIM21.25774560
42LRRK21.25425713
43GRK71.23687906
44TESK21.18075357
45HCK1.14361538
46TRIB31.13532339
47LCK1.13022383
48MATK1.10159758
49LYN1.09842864
50MAP3K11.08459681
51MST41.07252172
52TRPM71.05603041
53PRKG21.04288225
54SIK31.03894067
55MAP3K31.02355910
56PIM11.01364268
57NLK1.01006130
58TAOK30.99038224
59RIPK10.98532353
60IRAK10.96949414
61PAK40.94655568
62CHUK0.92593172
63RPS6KA40.91054302
64PRKD20.87032814
65JAK20.86573578
66MARK30.86257526
67FES0.85064730
68PTK60.85032844
69MAP3K130.81403906
70FGFR40.81076146
71CAMK1D0.77124120
72PDK10.76713975
73CDC42BPA0.74350214
74PDPK10.70367215
75STK40.66138528
76TGFBR10.65775507
77MAP3K120.64458399
78FRK0.63185908
79MAP3K100.62083611
80FGFR30.61779912
81CAMKK20.61060590
82MAP2K60.59558900
83MAPKAPK30.59447405
84MAPK70.59354538
85MST1R0.59281593
86PRKCD0.58686082
87ADRBK20.58410209
88MAP3K110.57027763
89DMPK0.56558740
90GRK60.56042201
91ABL10.55580285
92MAP3K20.55574489
93KSR20.55020136
94EPHA30.54575978
95PRKCQ0.54057969
96LMTK20.54004138
97MAP3K60.53237045
98DDR20.51496831
99FYN0.49043049
100EGFR0.48907660
101STK240.48689404
102PIK3CA0.48360725
103HIPK20.46079634
104MAP2K20.45201972
105IRAK20.45107098
106IGF1R0.43618938
107SCYL20.43616759
108MAPKAPK20.43459490
109FGR0.41865612
110CLK10.41780610
111PIK3CG0.39752290
112MOS0.39685473
113YES10.39506577
114MAPK110.39395383
115GRK10.39163185
116PRKAA20.38226611
117MAPK120.37952357
118RPS6KA60.37542627
119MARK20.36392585
120CDK190.36280942
121EIF2AK20.35719850
122MAP3K50.35401999
123INSRR0.31841124
124DAPK20.31112547
125MAP3K70.29611946
126PTK2B0.29505302
127ABL20.28941775
128PRKD10.28798051
129DAPK30.27403971
130RPS6KC10.27358020
131RPS6KL10.27358020
132MUSK0.26866847

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.17232085
2Staphylococcus aureus infection_Homo sapiens_hsa051502.98929818
3Osteoclast differentiation_Homo sapiens_hsa043802.53058379
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.46504042
5Other glycan degradation_Homo sapiens_hsa005112.41929469
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.33501105
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.29673970
8Lysosome_Homo sapiens_hsa041422.24266395
9Legionellosis_Homo sapiens_hsa051342.23865912
10Pertussis_Homo sapiens_hsa051332.20568306
11Malaria_Homo sapiens_hsa051442.19114025
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16951059
13Measles_Homo sapiens_hsa051622.06631292
14Graft-versus-host disease_Homo sapiens_hsa053321.97940740
15Hematopoietic cell lineage_Homo sapiens_hsa046401.94984744
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.93702073
17B cell receptor signaling pathway_Homo sapiens_hsa046621.92625550
18* Tuberculosis_Homo sapiens_hsa051521.85554294
19Antigen processing and presentation_Homo sapiens_hsa046121.79659700
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79440053
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79352740
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76692847
23Allograft rejection_Homo sapiens_hsa053301.75562394
24Rheumatoid arthritis_Homo sapiens_hsa053231.69094316
25Primary immunodeficiency_Homo sapiens_hsa053401.66760075
26Salmonella infection_Homo sapiens_hsa051321.62021830
27* Toxoplasmosis_Homo sapiens_hsa051451.60996981
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60772167
29Influenza A_Homo sapiens_hsa051641.57379490
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50755887
31TNF signaling pathway_Homo sapiens_hsa046681.48915947
32Viral myocarditis_Homo sapiens_hsa054161.47419503
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.42712220
34Phagosome_Homo sapiens_hsa041451.42536111
35Apoptosis_Homo sapiens_hsa042101.39127926
36* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38542703
37Shigellosis_Homo sapiens_hsa051311.35988215
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35667901
39Herpes simplex infection_Homo sapiens_hsa051681.32657526
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29306617
41* Jak-STAT signaling pathway_Homo sapiens_hsa046301.26461212
42Caffeine metabolism_Homo sapiens_hsa002321.26184709
43Chemokine signaling pathway_Homo sapiens_hsa040621.22176883
44Asthma_Homo sapiens_hsa053101.19700867
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08596862
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05923542
47African trypanosomiasis_Homo sapiens_hsa051431.04565579
48Hepatitis B_Homo sapiens_hsa051611.01377741
49Platelet activation_Homo sapiens_hsa046111.00464984
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97762264
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93843037
52Amoebiasis_Homo sapiens_hsa051460.92702132
53Hepatitis C_Homo sapiens_hsa051600.91722365
54Acute myeloid leukemia_Homo sapiens_hsa052210.90092221
55T cell receptor signaling pathway_Homo sapiens_hsa046600.89677125
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82395193
57Collecting duct acid secretion_Homo sapiens_hsa049660.76563096
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73694376
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73313747
60Small cell lung cancer_Homo sapiens_hsa052220.72003746
61Chronic myeloid leukemia_Homo sapiens_hsa052200.71469797
62Autoimmune thyroid disease_Homo sapiens_hsa053200.68042637
63Pancreatic cancer_Homo sapiens_hsa052120.67563435
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.67464021
65HIF-1 signaling pathway_Homo sapiens_hsa040660.66113397
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65827014
67Type I diabetes mellitus_Homo sapiens_hsa049400.65701173
68Complement and coagulation cascades_Homo sapiens_hsa046100.62967798
69Sphingolipid metabolism_Homo sapiens_hsa006000.59686958
70Mineral absorption_Homo sapiens_hsa049780.59324363
71Sulfur metabolism_Homo sapiens_hsa009200.57698661
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55904595
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55212861
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54522814
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54123729
76Renin-angiotensin system_Homo sapiens_hsa046140.52734478
77Insulin resistance_Homo sapiens_hsa049310.50576365
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47158471
79ABC transporters_Homo sapiens_hsa020100.46861713
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46773534
81Focal adhesion_Homo sapiens_hsa045100.46149589
82VEGF signaling pathway_Homo sapiens_hsa043700.45136654
83Arachidonic acid metabolism_Homo sapiens_hsa005900.45118008
84Galactose metabolism_Homo sapiens_hsa000520.43516512
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42491890
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39430797
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.38961008
88Endocytosis_Homo sapiens_hsa041440.38688971
89Dilated cardiomyopathy_Homo sapiens_hsa054140.38366599
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.37424218
91Non-small cell lung cancer_Homo sapiens_hsa052230.37038443
92PPAR signaling pathway_Homo sapiens_hsa033200.36586478
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36114469
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35345530
95Notch signaling pathway_Homo sapiens_hsa043300.34967184
96Adherens junction_Homo sapiens_hsa045200.34318507
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34306779
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33851408
99Starch and sucrose metabolism_Homo sapiens_hsa005000.33718846
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.33129133
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32866976
102Proteoglycans in cancer_Homo sapiens_hsa052050.32051359
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31397042
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.31085489
105Prolactin signaling pathway_Homo sapiens_hsa049170.30422745
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30354800
107Viral carcinogenesis_Homo sapiens_hsa052030.28100024
108HTLV-I infection_Homo sapiens_hsa051660.28075440
109Fructose and mannose metabolism_Homo sapiens_hsa000510.27699383
110Regulation of autophagy_Homo sapiens_hsa041400.27416916
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27144053
112Dorso-ventral axis formation_Homo sapiens_hsa043200.26572692
113* Epstein-Barr virus infection_Homo sapiens_hsa051690.25330705
114Vibrio cholerae infection_Homo sapiens_hsa051100.25060385
115Systemic lupus erythematosus_Homo sapiens_hsa053220.23634993
116FoxO signaling pathway_Homo sapiens_hsa040680.19514006
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.18557795

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