IL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of response to osmotic stress (GO:0047484)9.34808567
2erythrocyte maturation (GO:0043249)7.32442327
3cellular hyperosmotic response (GO:0071474)7.22036391
4negative regulation of myeloid cell apoptotic process (GO:0033033)7.08343022
5lung vasculature development (GO:0060426)7.01745651
6hemoglobin metabolic process (GO:0020027)6.85720574
7positive regulation of astrocyte differentiation (GO:0048711)6.56294274
8positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.07614413
9regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.07614413
10negative regulation of cation channel activity (GO:2001258)5.83020898
11endodermal cell differentiation (GO:0035987)5.74491826
12neutrophil activation involved in immune response (GO:0002283)5.66710127
13cellular response to vitamin D (GO:0071305)5.24746277
14lung lobe morphogenesis (GO:0060463)5.22356144
15regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.21930544
16positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.21587002
17regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.11985150
18response to increased oxygen levels (GO:0036296)5.11500885
19response to hyperoxia (GO:0055093)5.11500885
20sequestering of actin monomers (GO:0042989)4.99638789
21substrate-dependent cell migration (GO:0006929)4.82266380
22protein heterotrimerization (GO:0070208)4.82002240
23Golgi transport vesicle coating (GO:0048200)4.74532038
24COPI coating of Golgi vesicle (GO:0048205)4.74532038
25mammary gland epithelial cell proliferation (GO:0033598)4.56801485
26cellular response to vitamin (GO:0071295)4.32683917
27tyrosine phosphorylation of STAT protein (GO:0007260)4.24758140
28muscle cell migration (GO:0014812)4.15499872
29mesenchymal-epithelial cell signaling (GO:0060638)4.12228895
30decidualization (GO:0046697)4.11055403
31regulation of gonadotropin secretion (GO:0032276)4.10213453
32trophoblast giant cell differentiation (GO:0060707)4.08881990
33protein hydroxylation (GO:0018126)4.08225179
34positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.04228482
35type B pancreatic cell proliferation (GO:0044342)4.00492429
36peptidyl-proline hydroxylation (GO:0019511)3.95929569
37muscle organ morphogenesis (GO:0048644)3.94729595
38response to vitamin A (GO:0033189)3.94063783
39positive regulation of blood vessel endothelial cell migration (GO:0043536)3.91227688
40cell migration involved in sprouting angiogenesis (GO:0002042)3.89331756
41negative regulation of leukocyte chemotaxis (GO:0002689)3.80260209
42negative regulation of meiosis (GO:0045835)3.79514683
43regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.78340410
44regulation of myeloid cell apoptotic process (GO:0033032)3.73654621
45regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418)3.72138674
46collagen metabolic process (GO:0032963)3.69370643
47collagen fibril organization (GO:0030199)3.66821507
48collagen catabolic process (GO:0030574)3.66088614
49heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.63165005
50positive regulation of metanephros development (GO:0072216)3.59409983
51positive regulation of osteoblast proliferation (GO:0033690)3.53535523
52limb bud formation (GO:0060174)3.52326894
53response to testosterone (GO:0033574)3.52105550
54mesodermal cell differentiation (GO:0048333)3.51678923
55positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.51093181
56protein neddylation (GO:0045116)3.50363604
57negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.49321455
58UDP-N-acetylglucosamine metabolic process (GO:0006047)3.44849999
59phospholipid scrambling (GO:0017121)3.43597686
60kidney mesenchyme development (GO:0072074)3.42925966
61multicellular organismal catabolic process (GO:0044243)3.39961847
62hypotonic response (GO:0006971)3.39337797
63multicellular organismal macromolecule metabolic process (GO:0044259)3.37551390
64negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.36350838
65sequestering of extracellular ligand from receptor (GO:0035581)3.36167927
66positive regulation of Ras protein signal transduction (GO:0046579)3.36054501
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32338478
68positive regulation of macrophage differentiation (GO:0045651)3.27954647
69multicellular organismal metabolic process (GO:0044236)3.27103083
70fibrinolysis (GO:0042730)3.26695379
71regulation of protein heterodimerization activity (GO:0043497)3.24107587
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.23999823
73endocrine hormone secretion (GO:0060986)3.23707426
74neutrophil activation (GO:0042119)3.23585759
75midgut development (GO:0007494)3.23421477
76regulation of glucocorticoid metabolic process (GO:0031943)3.23360007
77tumor necrosis factor-mediated signaling pathway (GO:0033209)3.21413617
78response to vitamin D (GO:0033280)3.19791331
79positive regulation of actin cytoskeleton reorganization (GO:2000251)3.17835290
80response to electrical stimulus (GO:0051602)3.16912923
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.16667628
82protein retention in ER lumen (GO:0006621)3.16022287
83protein localization to endosome (GO:0036010)3.15123620
84dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.14097605
85wound healing, spreading of cells (GO:0044319)3.12237567
86regulation of transmission of nerve impulse (GO:0051969)3.11856468
87extracellular matrix disassembly (GO:0022617)3.10250261
88hemidesmosome assembly (GO:0031581)3.05869832
89pericardium development (GO:0060039)3.04553015
90regulation of monocyte chemotaxis (GO:0090025)2.99137210
91positive regulation of immune response to tumor cell (GO:0002839)2.96767960
92regulation of immune response to tumor cell (GO:0002837)2.96767960
93regulation of response to tumor cell (GO:0002834)2.96767960
94positive regulation of response to tumor cell (GO:0002836)2.96767960
95positive regulation of axon extension (GO:0045773)2.96743957
96regulation of metalloenzyme activity (GO:0048552)2.96323899
97chondrocyte proliferation (GO:0035988)2.95964797
98negative regulation of calcium ion transport (GO:0051926)2.95678485
99aggressive behavior (GO:0002118)2.94520053
100endothelial cell morphogenesis (GO:0001886)2.92957493
101extracellular negative regulation of signal transduction (GO:1900116)2.90940150
102extracellular regulation of signal transduction (GO:1900115)2.90940150
103granulocyte activation (GO:0036230)2.90886679
104detection of bacterium (GO:0016045)2.90756499
105proteoglycan biosynthetic process (GO:0030166)2.90424373
106positive regulation of actin filament depolymerization (GO:0030836)2.90286056
107hyaluronan catabolic process (GO:0030214)2.90150534
108negative regulation of smooth muscle cell migration (GO:0014912)2.89786386
109regulation of mast cell degranulation (GO:0043304)2.88601810
110regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.87689964
111positive regulation of macrophage activation (GO:0043032)2.87040996
112positive regulation of small GTPase mediated signal transduction (GO:0051057)2.86969883
113activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.85257974
114negative regulation of protein autophosphorylation (GO:0031953)2.85231222
115detection of mechanical stimulus involved in sensory perception (GO:0050974)2.85027607
116wound healing (GO:0042060)2.84615270
117behavioral response to pain (GO:0048266)2.84611475
118pathway-restricted SMAD protein phosphorylation (GO:0060389)2.83752944
119response to gravity (GO:0009629)2.82609058
120kidney morphogenesis (GO:0060993)2.80967574
121response to redox state (GO:0051775)2.80054692
122negative regulation of chondrocyte differentiation (GO:0032331)2.79311478
123nucleotide transmembrane transport (GO:1901679)2.79227452
124regulation of apoptotic process involved in morphogenesis (GO:1902337)2.78462806
125hyperosmotic response (GO:0006972)2.77738881
126response to salt stress (GO:0009651)2.77271435
127regulation of mast cell activation involved in immune response (GO:0033006)2.76149236
128response to water (GO:0009415)2.74321030
129nucleoside diphosphate catabolic process (GO:0009134)2.74053037
130regulation of smooth muscle cell migration (GO:0014910)2.73086776
131positive regulation of protein autophosphorylation (GO:0031954)2.72696627
132regulation of G0 to G1 transition (GO:0070316)2.71744891
133basement membrane organization (GO:0071711)2.71147145
134skin morphogenesis (GO:0043589)2.69390348
135negative regulation of ion transmembrane transporter activity (GO:0032413)2.68220262
136cell-substrate junction assembly (GO:0007044)2.68181410
137blood vessel endothelial cell migration (GO:0043534)2.67395922
138positive regulation of monocyte chemotaxis (GO:0090026)2.67363228
139positive regulation of positive chemotaxis (GO:0050927)2.67276312
140positive regulation of meiosis (GO:0045836)2.67169745
141negative regulation of smooth muscle cell differentiation (GO:0051151)2.67159781
142vagina development (GO:0060068)2.66706719
143negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.66439716
144regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66384136
145cellular senescence (GO:0090398)2.66074035
146mammary gland development (GO:0030879)2.65929805
147glycoprotein biosynthetic process (GO:0009101)2.63304776
148chondroitin sulfate biosynthetic process (GO:0030206)2.62887017
149cell adhesion mediated by integrin (GO:0033627)2.62791978
150detection of other organism (GO:0098543)2.62308290
151regulation of mast cell activation (GO:0033003)2.57423247
152positive regulation of receptor activity (GO:2000273)2.57087746
153regulation of protein autophosphorylation (GO:0031952)2.57034883
154iron coordination entity transport (GO:1901678)2.56367000
155GDP-mannose metabolic process (GO:0019673)2.56339443
156eye photoreceptor cell differentiation (GO:0001754)2.55811334
157photoreceptor cell differentiation (GO:0046530)2.55811334
158negative regulation of myoblast differentiation (GO:0045662)2.55260381
159regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)2.55114564
160hepatocyte differentiation (GO:0070365)2.54000864
161protein heterotetramerization (GO:0051290)2.53032737
162neuronal action potential propagation (GO:0019227)2.52330538
163retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51396605
164short-term memory (GO:0007614)2.47030854
165positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.47006782
166regulation of amyloid precursor protein catabolic process (GO:1902991)2.45681067
167adenosine metabolic process (GO:0046085)2.43759258
168cellular response to osmotic stress (GO:0071470)2.41328188
169actin filament depolymerization (GO:0030042)2.40602632
170regulation of meiosis I (GO:0060631)2.38322288
171wound healing, spreading of epidermal cells (GO:0035313)2.38070725
172positive regulation of meiotic cell cycle (GO:0051446)2.37945823
173regulated secretory pathway (GO:0045055)2.36120511
174protein maturation by protein folding (GO:0022417)2.36064566
175mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.35798979
176regulation of male gonad development (GO:2000018)2.35708284
177lung epithelium development (GO:0060428)2.35270672
178protein localization to cilium (GO:0061512)2.34141918
179negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.33488988
180neural crest cell development (GO:0014032)2.32122309
181omega-hydroxylase P450 pathway (GO:0097267)2.31665226
182vesicle docking involved in exocytosis (GO:0006904)2.30450588
183positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.28485531
184nucleotide-sugar biosynthetic process (GO:0009226)2.27962217
185keratinocyte proliferation (GO:0043616)2.27355527
186peripheral nervous system neuron development (GO:0048935)2.26174238
187regulation of interleukin-8 secretion (GO:2000482)2.25982282
188negative regulation of leukocyte migration (GO:0002686)2.23766697
189chondrocyte development (GO:0002063)2.23283968
190negative regulation of calcium ion transport into cytosol (GO:0010523)11.8094622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.19219075
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.64528906
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.45464368
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.12343373
5RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.12252016
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.05895325
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91830870
8BRD4_25478319_ChIP-Seq_HGPS_Human2.89505878
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.87560126
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82826214
11ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.75624504
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.72690839
13GBX2_23144817_ChIP-Seq_PC3_Human2.71656546
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64137730
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62930097
16CLOCK_20551151_ChIP-Seq_293T_Human2.60676320
17* TP53_22127205_ChIP-Seq_IMR90_Human2.50184060
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41632154
19JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33714585
20JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30291742
21UBF1/2_26484160_Chip-Seq_HMECs_Human2.27155496
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24030146
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23418828
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.23187380
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14478931
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11393302
27HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07770673
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.99726851
29ATF3_27146783_Chip-Seq_COLON_Human1.99610194
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99292038
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.98976237
32TAF15_26573619_Chip-Seq_HEK293_Human1.98853410
33ER_23166858_ChIP-Seq_MCF-7_Human1.96615064
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95718502
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95337385
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.92106216
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.91988442
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90125791
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88369261
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83341034
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.83142608
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82866809
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81442835
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80853951
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80445129
46TP53_18474530_ChIP-ChIP_U2OS_Human1.77083385
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75232000
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75232000
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74873237
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73423022
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73321647
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71911949
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70647923
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69255553
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66261589
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64907147
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.61871414
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.61023225
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56762026
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.55123878
61SMC1_22415368_ChIP-Seq_MEFs_Mouse1.54203082
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54150326
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52993293
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.51653216
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.50473547
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.49332899
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48848578
68* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47232255
69ZNF263_19887448_ChIP-Seq_K562_Human1.45755126
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45616698
71RNF2_27304074_Chip-Seq_NSC_Mouse1.44978224
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44835905
73P53_22387025_ChIP-Seq_ESCs_Mouse1.44604205
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44601479
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43625086
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42883359
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42883359
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42883359
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42614572
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42053989
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41753075
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.41450310
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40903252
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40903252
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40111182
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39978235
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.39555326
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.39525380
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39129192
90NMYC_18555785_Chip-Seq_ESCs_Mouse1.38402433
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.38120756
92P300_19829295_ChIP-Seq_ESCs_Human1.37715218
93AR_21572438_ChIP-Seq_LNCaP_Human1.35068729
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.34271187
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.33219888
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32293049
97P300_18555785_Chip-Seq_ESCs_Mouse1.32235940
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32179036
99MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31055061
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30037955
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.29809059
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29564347
103TP53_23651856_ChIP-Seq_MEFs_Mouse1.29363993
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29283013
105CJUN_26792858_Chip-Seq_BT549_Human1.29278011
106* EZH2_27294783_Chip-Seq_ESCs_Mouse1.26653598
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26430642
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26196877
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.26067353
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25418374
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25102416
112JUN_21703547_ChIP-Seq_K562_Human1.24833583
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23780862
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23780862
115SALL1_21062744_ChIP-ChIP_HESCs_Human1.19068406
116SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17947936
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.17838359
118RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17806335
119RACK7_27058665_Chip-Seq_MCF-7_Human1.15124229
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14728303
121SMAD4_21799915_ChIP-Seq_A2780_Human1.14073173
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14052716
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13470592
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.12995929
125KLF4_18555785_Chip-Seq_ESCs_Mouse1.11966951
126ZFX_18555785_Chip-Seq_ESCs_Mouse1.11957303
127VDR_22108803_ChIP-Seq_LS180_Human1.11693825
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11132121
129RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11094241
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11039688
131SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11016630
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10290912
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09791085
134EZH2_27294783_Chip-Seq_NPCs_Mouse1.09543898
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09473718
136RNF2_27304074_Chip-Seq_ESCs_Mouse1.09319791
137FOXO3_23340844_ChIP-Seq_DLD1_Human1.08162250
138LXR_22292898_ChIP-Seq_THP-1_Human1.07716061
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07234762
140SA1_22415368_ChIP-Seq_MEFs_Mouse1.07232413
141OCT4_18555785_Chip-Seq_ESCs_Mouse1.06577029
142AR_21909140_ChIP-Seq_LNCAP_Human1.05244353
143TP53_20018659_ChIP-ChIP_R1E_Mouse1.04884746
144ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04878361
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03913866
146SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02456882
147NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01703777
148SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01019903
149SMAD1_18555785_Chip-Seq_ESCs_Mouse1.00583949
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00157209
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99895648
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98558501
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96802429
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95257911
155PU1_27457419_Chip-Seq_LIVER_Mouse0.94867589
156RUNX2_22187159_ChIP-Seq_PCA_Human0.94740821
157* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94263651
158NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93987595
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93924180
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93194473
161SOX2_20726797_ChIP-Seq_SW620_Human0.93191670
162CTCF_18555785_Chip-Seq_ESCs_Mouse0.92588781
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92295316
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91395874
165KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91122249
166TET1_21451524_ChIP-Seq_MESCs_Mouse0.90475160
167TBX20_22328084_ChIP-Seq_HEART_Mouse0.90412965
168TBX20_22080862_ChIP-Seq_HEART_Mouse0.90412965
169PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.88543620
170THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88143298
171TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87711913
172TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87422356
173NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87012337
174TET1_21490601_ChIP-Seq_MESCs_Mouse0.86308653
175* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85875269
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85269973
177SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84392593
178CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84252310
179CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83851652
180TP53_16413492_ChIP-PET_HCT116_Human0.82831849
181ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82528693
182SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81791955
183TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80979050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.28682062
2MP0004270_analgesia4.01254461
3MP0003705_abnormal_hypodermis_morpholog3.50590803
4MP0001188_hyperpigmentation3.34458844
5MP0003566_abnormal_cell_adhesion3.28758597
6MP0010352_gastrointestinal_tract_polyps3.27256715
7MP0002735_abnormal_chemical_nociception3.24363594
8MP0000566_synostosis3.13420086
9MP0010368_abnormal_lymphatic_system2.77275800
10MP0009780_abnormal_chondrocyte_physiolo2.72936832
11MP0000013_abnormal_adipose_tissue2.49653276
12MP0000751_myopathy2.33483013
13MP0006276_abnormal_autonomic_nervous2.32837976
14MP0009250_abnormal_appendicular_skeleto2.31435249
15MP0002877_abnormal_melanocyte_morpholog2.30191061
16MP0005503_abnormal_tendon_morphology2.22298926
17MP0006292_abnormal_olfactory_placode2.18804586
18MP0010030_abnormal_orbit_morphology2.09774328
19MP0002734_abnormal_mechanical_nocicepti2.09503877
20MP0005171_absent_coat_pigmentation2.08132315
21MP0003880_abnormal_central_pattern1.98699715
22MP0008438_abnormal_cutaneous_collagen1.94474676
23MP0003950_abnormal_plasma_membrane1.93472167
24MP0000750_abnormal_muscle_regeneration1.92884932
25MP0005084_abnormal_gallbladder_morpholo1.92379176
26MP0004742_abnormal_vestibular_system1.88175331
27MP0001986_abnormal_taste_sensitivity1.83155474
28MP0001958_emphysema1.83096919
29MP0002060_abnormal_skin_morphology1.82123198
30MP0002102_abnormal_ear_morphology1.79610830
31MP0002751_abnormal_autonomic_nervous1.78642665
32MP0009053_abnormal_anal_canal1.77386911
33MP0002736_abnormal_nociception_after1.75851636
34MP0001346_abnormal_lacrimal_gland1.71931236
35MP0006054_spinal_hemorrhage1.71102240
36MP0003941_abnormal_skin_development1.67547709
37MP0000762_abnormal_tongue_morphology1.63653837
38MP0000767_abnormal_smooth_muscle1.62405679
39MP0005623_abnormal_meninges_morphology1.55870093
40MP0003755_abnormal_palate_morphology1.54600153
41MP0001542_abnormal_bone_strength1.53408420
42MP0005508_abnormal_skeleton_morphology1.52136174
43MP0000733_abnormal_muscle_development1.50218462
44MP0005164_abnormal_response_to1.48323858
45MP0002933_joint_inflammation1.47999920
46MP0005197_abnormal_uvea_morphology1.47062903
47MP0002277_abnormal_respiratory_mucosa1.46801915
48MP0003136_yellow_coat_color1.44402548
49MP0005083_abnormal_biliary_tract1.43156193
50MP0005408_hypopigmentation1.43089351
51MP0002184_abnormal_innervation1.42866187
52MP0001968_abnormal_touch/_nociception1.42793114
53MP0000858_altered_metastatic_potential1.41557431
54MP0010307_abnormal_tumor_latency1.41337142
55MP0008775_abnormal_heart_ventricle1.40264860
56MP0004858_abnormal_nervous_system1.40040807
57MP0003448_altered_tumor_morphology1.38863588
58MP0000534_abnormal_ureter_morphology1.38113529
59MP0000163_abnormal_cartilage_morphology1.36381396
60MP0001879_abnormal_lymphatic_vessel1.35917270
61MP0000003_abnormal_adipose_tissue1.33599565
62MP0005257_abnormal_intraocular_pressure1.30990978
63MP0000627_abnormal_mammary_gland1.30263799
64MP0005409_darkened_coat_color1.29173430
65MP0004808_abnormal_hematopoietic_stem1.28942187
66MP0002160_abnormal_reproductive_system1.27249115
67MP0001243_abnormal_dermal_layer1.25766596
68MP0002638_abnormal_pupillary_reflex1.23301201
69MP0004272_abnormal_basement_membrane1.21953393
70MP0005166_decreased_susceptibility_to1.21943209
71MP0002295_abnormal_pulmonary_circulatio1.20927147
72MP0009384_cardiac_valve_regurgitation1.20421151
73MP0001905_abnormal_dopamine_level1.19615983
74MP0001970_abnormal_pain_threshold1.19502721
75MP0004134_abnormal_chest_morphology1.19404178
76MP0003279_aneurysm1.18008487
77MP0004510_myositis1.16393298
78MP0005410_abnormal_fertilization1.16000065
79MP0002109_abnormal_limb_morphology1.15917749
80MP0005423_abnormal_somatic_nervous1.14852995
81MP0010386_abnormal_urinary_bladder1.14312683
82MP0002938_white_spotting1.12978728
83MP0003385_abnormal_body_wall1.11494796
84MP0001881_abnormal_mammary_gland1.11250200
85MP0003942_abnormal_urinary_system1.10623336
86MP0002115_abnormal_skeleton_extremities1.10240446
87MP0004142_abnormal_muscle_tone1.10133764
88MP0001915_intracranial_hemorrhage1.06713122
89MP0000537_abnormal_urethra_morphology1.05715327
90MP0000049_abnormal_middle_ear1.04584775
91MP0002876_abnormal_thyroid_physiology1.04040357
92MP0002282_abnormal_trachea_morphology1.02986738
93MP0002113_abnormal_skeleton_development1.02953534
94MP0002733_abnormal_thermal_nociception1.01645032
95MP0003937_abnormal_limbs/digits/tail_de1.00555331
96MP0001664_abnormal_digestion0.98900521
97MP0000015_abnormal_ear_pigmentation0.98228992
98MP0002254_reproductive_system_inflammat0.98060005
99MP0002177_abnormal_outer_ear0.97218512
100MP0005595_abnormal_vascular_smooth0.96165603
101MP0003315_abnormal_perineum_morphology0.95734110
102MP0008932_abnormal_embryonic_tissue0.95584619
103MP0003724_increased_susceptibility_to0.95379083
104MP0001299_abnormal_eye_distance/0.94546702
105MP0005390_skeleton_phenotype0.94363916
106MP0001348_abnormal_lacrimal_gland0.93065177
107MP0002998_abnormal_bone_remodeling0.92651004
108MP0005310_abnormal_salivary_gland0.91001404
109MP0002932_abnormal_joint_morphology0.89266375
110MP0001849_ear_inflammation0.88848278
111MP0002116_abnormal_craniofacial_bone0.88434970
112MP0001661_extended_life_span0.88035849
113MP0000490_abnormal_crypts_of0.87535026
114MP0002089_abnormal_postnatal_growth/wei0.86241971
115MP0008004_abnormal_stomach_pH0.86200725
116MP0000343_altered_response_to0.85881665
117MP0001533_abnormal_skeleton_physiology0.85479732
118MP0005165_increased_susceptibility_to0.85204895
119MP0009840_abnormal_foam_cell0.85030465
120MP0002233_abnormal_nose_morphology0.84024382
121MP0002128_abnormal_blood_circulation0.83757317
122MP0005275_abnormal_skin_tensile0.82714659
123MP0005389_reproductive_system_phenotype0.82425449
124MP0001614_abnormal_blood_vessel0.82184898
125MP0000470_abnormal_stomach_morphology0.81489904
126MP0003936_abnormal_reproductive_system0.81348895
127MP0000778_abnormal_nervous_system0.81064863
128MP0002332_abnormal_exercise_endurance0.80533311
129MP0004381_abnormal_hair_follicle0.80248601
130MP0008789_abnormal_olfactory_epithelium0.79531630
131MP0003436_decreased_susceptibility_to0.79412290
132MP0010771_integument_phenotype0.79362343
133MP0003045_fibrosis0.78699218
134MP0000613_abnormal_salivary_gland0.78028308
135MP0003091_abnormal_cell_migration0.75472585
136MP0003075_altered_response_to0.75289908
137MP0002925_abnormal_cardiovascular_devel0.74332616
138MP0001270_distended_abdomen0.74048443
139MP0009785_altered_susceptibility_to0.73155738
140MP0002064_seizures0.73085187
141MP0002752_abnormal_somatic_nervous0.72980737
142MP0005645_abnormal_hypothalamus_physiol0.72773893
143MP0000579_abnormal_nail_morphology0.72315548
144MP0005023_abnormal_wound_healing0.72223778
145MP0004145_abnormal_muscle_electrophysio0.71720349
146MP0003300_gastrointestinal_ulcer0.71671065
147MP0000026_abnormal_inner_ear0.71026202
148MP0002896_abnormal_bone_mineralization0.70969194
149MP0001919_abnormal_reproductive_system0.70896106
150MP0001440_abnormal_grooming_behavior0.70883289
151MP0000681_abnormal_thyroid_gland0.70757328
152MP0001984_abnormal_olfaction0.70399896
153MP0005451_abnormal_body_composition0.70393298
154MP0001727_abnormal_embryo_implantation0.70389963
155MP0003632_abnormal_nervous_system0.69576437
156MP0002168_other_aberrant_phenotype0.68997061
157MP0000759_abnormal_skeletal_muscle0.67609311
158MP0000428_abnormal_craniofacial_morphol0.66020343
159MP0000432_abnormal_head_morphology0.64608232
160MP0001340_abnormal_eyelid_morphology0.63333005
161MP0003453_abnormal_keratinocyte_physiol0.62701711
162MP0002972_abnormal_cardiac_muscle0.62112856

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)6.10264768
2Follicular hyperkeratosis (HP:0007502)5.83100222
3Protrusio acetabuli (HP:0003179)5.48421286
4Abnormality of incisor morphology (HP:0011063)4.95844456
5Popliteal pterygium (HP:0009756)4.80622435
6Achilles tendon contracture (HP:0001771)4.77277344
7Type 1 muscle fiber predominance (HP:0003803)4.72268261
8Slender build (HP:0001533)4.56104194
9Nasolacrimal duct obstruction (HP:0000579)4.30662205
10Fragile skin (HP:0001030)4.29314046
11Abnormality of the Achilles tendon (HP:0005109)4.24638806
12Aortic dissection (HP:0002647)4.12428083
13Genu recurvatum (HP:0002816)4.06057478
14Abnormal hair whorl (HP:0010721)3.85692285
15Spinal rigidity (HP:0003306)3.84505494
16Ankyloglossia (HP:0010296)3.78094794
17Abnormality of dentin (HP:0010299)3.71489746
18Soft skin (HP:0000977)3.70047676
19Arterial tortuosity (HP:0005116)3.69129262
20Abnormality of oral frenula (HP:0000190)3.63435216
21Abnormality of the nasal septum (HP:0000419)3.57748052
22Vascular tortuosity (HP:0004948)3.52100465
23Xerostomia (HP:0000217)3.51655327
24Bladder diverticulum (HP:0000015)3.49537469
25Obstructive sleep apnea (HP:0002870)3.45490768
26Hypoventilation (HP:0002791)3.41192496
27Abnormality of the lacrimal duct (HP:0011481)3.40441442
28Epiphyseal dysplasia (HP:0002656)3.36422752
29Febrile seizures (HP:0002373)3.31698727
30Abnormality of the aortic arch (HP:0012303)3.31606673
31Premature rupture of membranes (HP:0001788)3.27655058
32Episodic fever (HP:0001954)3.23694560
33Mildly elevated creatine phosphokinase (HP:0008180)3.22945344
34Elbow flexion contracture (HP:0002987)3.22175046
35Irregular epiphyses (HP:0010582)3.21246286
36Long toe (HP:0010511)3.09234326
37Vertebral compression fractures (HP:0002953)3.08245520
38Mitral valve prolapse (HP:0001634)3.07945771
39Abnormality of the nasolacrimal system (HP:0000614)3.06707551
40Hypothermia (HP:0002045)3.00280816
41Submucous cleft hard palate (HP:0000176)2.98456487
42Overgrowth (HP:0001548)2.96463749
43Wormian bones (HP:0002645)2.93220217
44Blue sclerae (HP:0000592)2.92778747
45Abnormality of the phalanges of the hallux (HP:0010057)2.85886508
46Renal duplication (HP:0000075)2.83715482
47Ulnar bowing (HP:0003031)2.79488518
48Increased variability in muscle fiber diameter (HP:0003557)2.75535210
49Sensory axonal neuropathy (HP:0003390)2.73307038
50Barrel-shaped chest (HP:0001552)2.72841777
51Redundant skin (HP:0001582)2.71848019
52Peritonitis (HP:0002586)2.66696216
53Protruding ear (HP:0000411)2.66666031
54Concave nail (HP:0001598)2.66100210
55Abnormality of femoral epiphyses (HP:0006499)2.64348274
56Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.64348274
57Myokymia (HP:0002411)2.64008881
58Abnormality of the parietal bone (HP:0002696)2.63441702
59Abnormal hemoglobin (HP:0011902)2.62253816
60Hypoplastic iliac wings (HP:0002866)2.58810969
61Bronchomalacia (HP:0002780)2.58455860
62Cone-rod dystrophy (HP:0000548)2.58406285
63Abnormality of the epiphysis of the femoral head (HP:0010574)2.53775879
64Abnormality of macrophages (HP:0004311)2.51495698
65Abnormality of the femoral head (HP:0003368)2.50449504
66Aortic aneurysm (HP:0004942)2.47317612
67Upper limb muscle weakness (HP:0003484)2.47142892
68Vitreoretinal degeneration (HP:0000655)2.46661817
69Sleep apnea (HP:0010535)2.44771383
70Aplasia involving bones of the extremities (HP:0009825)2.43462072
71Aplasia involving bones of the upper limbs (HP:0009823)2.43462072
72Aplasia of the phalanges of the hand (HP:0009802)2.43462072
73Atrophic scars (HP:0001075)2.41377168
74Neonatal short-limb short stature (HP:0008921)2.40339541
75Chronic hepatic failure (HP:0100626)2.38625934
76Generalized amyotrophy (HP:0003700)2.38545617
77Bradycardia (HP:0001662)2.34494846
78Bowel diverticulosis (HP:0005222)2.33327907
79Abnormality of skeletal muscle fiber size (HP:0012084)2.33307259
80Joint laxity (HP:0001388)2.31907906
81Limb-girdle muscle weakness (HP:0003325)2.28768036
82Fragile nails (HP:0001808)2.25586786
83Pterygium (HP:0001059)2.25146727
84Large earlobe (HP:0009748)2.24807505
85Shallow orbits (HP:0000586)2.22987087
86Parakeratosis (HP:0001036)2.21870573
87Hyperextensible skin (HP:0000974)2.17851008
88Deep palmar crease (HP:0006191)2.17234048
89Dilatation of the ascending aorta (HP:0005111)2.15052476
90Spondylolisthesis (HP:0003302)2.13119247
91Flared iliac wings (HP:0002869)2.10645940
92Hyperacusis (HP:0010780)2.08097011
93Hypoplastic ilia (HP:0000946)2.07559698
94Duplicated collecting system (HP:0000081)2.06861874
95Abnormality of the fibula (HP:0002991)2.06719684
96Natal tooth (HP:0000695)2.06561138
97Glucose intolerance (HP:0000833)2.06128450
98Increased connective tissue (HP:0009025)2.06048665
99Abnormal umbilical cord blood vessels (HP:0011403)2.05605183
100Single umbilical artery (HP:0001195)2.05605183
101Abnormality of the fetal cardiovascular system (HP:0010948)2.05605183
102Adrenal hypoplasia (HP:0000835)2.05348749
103Hypophosphatemic rickets (HP:0004912)2.04515219
104Biconcave vertebral bodies (HP:0004586)2.04455818
105Down-sloping shoulders (HP:0200021)2.04452236
106Medial flaring of the eyebrow (HP:0010747)2.03876560
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03230314
108Progressive sensorineural hearing impairment (HP:0000408)2.03106319
109Atonic seizures (HP:0010819)2.03029241
110Elfin facies (HP:0004428)2.02226875
111Congenital glaucoma (HP:0001087)2.01643810
112Distal lower limb muscle weakness (HP:0009053)2.01578101
113Small epiphyses (HP:0010585)2.00477589
114Selective tooth agenesis (HP:0001592)2.00432208
115Broad metatarsal (HP:0001783)2.00398364
116Overfolded helix (HP:0000396)2.00373440
117Fibular aplasia (HP:0002990)2.00310181
118Congenital sensorineural hearing impairment (HP:0008527)1.99439844
119Amyotrophic lateral sclerosis (HP:0007354)1.98268149
120Aortic regurgitation (HP:0001659)1.98009227
121Bowing of the arm (HP:0006488)1.97873696
122Bowed forearm bones (HP:0003956)1.97873696
123Cerebral aneurysm (HP:0004944)1.97688192
124Hallux valgus (HP:0001822)1.97599903
125Cardiovascular calcification (HP:0011915)1.95829145
126Spinal cord compression (HP:0002176)1.95606882
127Hydroureter (HP:0000072)1.94467323
128Increased serum ferritin (HP:0003281)1.94306617
129Tubulointerstitial nephritis (HP:0001970)1.93807860
130Arnold-Chiari malformation (HP:0002308)1.93600383
131Short nail (HP:0001799)1.93465581
132Cervical subluxation (HP:0003308)1.93216339
133Thoracolumbar scoliosis (HP:0002944)1.92584095
134Deviation of the hallux (HP:0010051)1.92546877
135Disproportionate tall stature (HP:0001519)1.92149124
136Osteolytic defects of the hand bones (HP:0009699)1.92061769
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.92061769
138Coxa vara (HP:0002812)1.91989278
139Hypoplastic toenails (HP:0001800)1.91911301
140Abnormal delivery (HP:0001787)1.90495730
141Neoplasm of the peripheral nervous system (HP:0100007)1.89919650
142Aplasia/hypoplasia of the femur (HP:0005613)1.89607679
143Abnormality of the incisor (HP:0000676)1.89164919
144Osteopenia (HP:0000938)1.88968321
145Abnormality of the acetabulum (HP:0003170)1.88586111
146Poor coordination (HP:0002370)1.87875051
147Broad face (HP:0000283)1.86609724
148Mixed hearing impairment (HP:0000410)1.86212723
149Mitral stenosis (HP:0001718)1.85696060
150Knee flexion contracture (HP:0006380)1.85460749
151Upper limb amyotrophy (HP:0009129)1.85098843
152Distal upper limb amyotrophy (HP:0007149)1.85098843
153Tibial bowing (HP:0002982)1.83551719
154Abnormality of the umbilical cord (HP:0010881)1.81277982
155Genu varum (HP:0002970)1.80399348
156Flat capital femoral epiphysis (HP:0003370)1.80103911
157Abnormality of the renal collecting system (HP:0004742)1.79957189
158Syringomyelia (HP:0003396)1.79932171
159Spinal cord lesions (HP:0100561)1.79932171
160Wrist flexion contracture (HP:0001239)1.79236367
161True hermaphroditism (HP:0010459)1.78658350
162Abnormality of the columella (HP:0009929)1.77467673
163Dyschromatopsia (HP:0007641)1.76856291
164Mitral regurgitation (HP:0001653)1.76851834
165Recurrent corneal erosions (HP:0000495)1.76701300
166Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76685145
167Short femoral neck (HP:0100864)1.76167642
168Menorrhagia (HP:0000132)1.75763552
169Deep venous thrombosis (HP:0002625)1.75434893
170Abnormality of the vocal cords (HP:0008777)1.74084251
171Increased corneal curvature (HP:0100692)1.73264669
172Keratoconus (HP:0000563)1.73264669
173Abnormal tarsal ossification (HP:0008369)1.73049384
174Congenital ichthyosiform erythroderma (HP:0007431)1.72135843
175Preaxial hand polydactyly (HP:0001177)1.71517285
176Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69697022
177Conical tooth (HP:0000698)1.68866932
178Aplasia/Hypoplasia of the lens (HP:0008063)1.67975479
179Hypoplastic pelvis (HP:0008839)1.67330903
180Abnormality of the distal phalanx of the thumb (HP:0009617)1.67262789
181Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66455210
182Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65727372
183Hypoplasia of dental enamel (HP:0006297)1.65014013
184Beaking of vertebral bodies (HP:0004568)1.64828349
185Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.64643046
186Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64448646
187Wide anterior fontanel (HP:0000260)1.64374607
188Atrophy/Degeneration involving motor neurons (HP:0007373)1.64344942
189Tracheomalacia (HP:0002779)1.63998036
190Limited hip movement (HP:0008800)1.62017511
191Split foot (HP:0001839)1.60262723
192Atelectasis (HP:0100750)1.58320511
193Dynein arm defect of respiratory motile cilia (HP:0012255)1.57794050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.10078494
2TTN3.40347567
3PDGFRA3.22922844
4LIMK13.02678728
5GRK52.88843837
6PIM22.87455409
7CASK2.76644795
8MYLK2.36438098
9ARAF2.24927456
10MKNK22.23746809
11FLT32.09481096
12EPHB22.03975406
13LMTK21.99301356
14PAK41.99219403
15TGFBR21.99184617
16TAOK21.97992354
17MET1.93373110
18IRAK31.90173363
19TRPM71.89969452
20ZAK1.76273812
21PNCK1.74541943
22BMPR1B1.73460426
23PAK21.72794133
24ERN11.70425825
25TRIB31.67425312
26MOS1.56759675
27NME21.56694937
28PLK21.56265048
29MAP3K121.56264446
30CSNK1A1L1.55480283
31NEK61.46730868
32CDK81.45891795
33TESK11.45114445
34STK161.42155501
35ICK1.35068511
36MST41.33727842
37MKNK11.31977624
38TEC1.31897764
39STK38L1.30799042
40GRK61.30461947
41IRAK41.30049644
42FER1.29185174
43EPHB11.28432963
44TSSK61.27894843
45CSNK1G31.26069514
46BLK1.22994351
47NEK91.22413932
48MAP2K71.10394113
49TNK21.09797263
50SCYL21.09030831
51ERBB31.08021051
52TLK11.07236276
53RPS6KB21.06459266
54MAPK131.05414233
55CAMK2B1.04151947
56INSRR1.03533493
57BRD41.01244586
58PTK2B1.00765810
59BMPR21.00591579
60PRKCE0.99377466
61NTRK30.99245586
62TXK0.98955791
63IRAK10.97974833
64MST1R0.97618105
65PRKD20.97183030
66MAP3K140.94347612
67OXSR10.94229467
68STK380.92645810
69RIPK10.92583284
70LATS20.91641165
71PAK30.91123361
72CSNK1G10.90671777
73KSR10.90603733
74CAMK2D0.90478448
75STK240.90394948
76MAP2K30.90002400
77NME10.89422891
78BRAF0.86773459
79PDGFRB0.86006545
80MELK0.85687675
81LATS10.85531527
82AKT30.82985032
83BCR0.82577284
84DAPK20.82202437
85RPS6KA20.80848931
86SIK10.80770476
87AURKA0.80088607
88GRK10.79650197
89STK390.79319253
90CAMK2G0.78498577
91CLK10.77080911
92CSNK1G20.74688371
93PKN20.74583229
94IRAK20.73413579
95STK30.71842012
96PRKG20.71324913
97MAP3K20.71081659
98DAPK30.70900983
99PAK10.70678109
100PAK60.69876973
101ZAP700.69800222
102NLK0.68159529
103MAP3K110.68009699
104ADRBK20.67598865
105YES10.67389275
106NEK10.66089766
107ILK0.65325519
108TNIK0.64716046
109ROCK10.64702375
110MAP2K20.64603505
111MAPKAPK50.64440002
112GSK3A0.63816527
113PKN10.63644142
114TESK20.62561305
115PRPF4B0.62461260
116PRKCI0.61608977
117BRSK20.61189161
118ADRBK10.61149515
119BRSK10.60726608
120ABL20.60333386
121CHUK0.60331205
122MAP3K80.59038791
123PTK20.58574204
124RPS6KL10.57303116
125RPS6KC10.57303116
126CDK90.57131251
127CAMK2A0.57127466
128DDR20.56851699
129CSK0.51839838
130ERBB40.50355728
131MTOR0.49861043
132PIK3CG0.49154072
133MAP3K50.48770895
134EIF2AK30.48425723
135FES0.46496983
136MAP3K30.45702866
137CDK70.45270612
138EIF2AK20.45263664
139RPS6KA60.44490729
140BUB10.44280916
141NTRK10.43796017
142PTK60.43347031
143DYRK1A0.42118304
144EPHA30.41752223
145DYRK20.40788214
146MAP3K10.39717814
147PRKCD0.38855271
148CDC42BPA0.38703250
149MARK10.38404942
150MAP3K130.37862038
151MAPK110.36075052
152AKT20.34761763
153DYRK1B0.34508116
154CDK150.33041437
155CDK180.31971254
156ROCK20.31967805
157CDK140.31889874
158ABL10.30930870
159NUAK10.30822418
160EIF2AK10.30086988
161CDK11A0.29041352
162TTK0.28908869
163MAP3K90.28036824
164MAP2K60.27842754
165BMX0.25914515
166MAPKAPK20.25848978

Predicted pathways (KEGG)

RankGene SetZ-score
1* Hematopoietic cell lineage_Homo sapiens_hsa046403.09897158
2Oxidative phosphorylation_Homo sapiens_hsa001902.51919284
3Ribosome_Homo sapiens_hsa030102.20256298
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13242895
5Protein export_Homo sapiens_hsa030602.10611832
6Small cell lung cancer_Homo sapiens_hsa052222.10127567
7RNA polymerase_Homo sapiens_hsa030202.05037340
8ECM-receptor interaction_Homo sapiens_hsa045122.01177649
9SNARE interactions in vesicular transport_Homo sapiens_hsa041301.95860665
10* Rheumatoid arthritis_Homo sapiens_hsa053231.76639100
11Parkinsons disease_Homo sapiens_hsa050121.76557779
12Chronic myeloid leukemia_Homo sapiens_hsa052201.69813279
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66943238
14MicroRNAs in cancer_Homo sapiens_hsa052061.66287279
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63157292
16Huntingtons disease_Homo sapiens_hsa050161.62735371
17Malaria_Homo sapiens_hsa051441.57028374
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.55692693
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55608227
20N-Glycan biosynthesis_Homo sapiens_hsa005101.54260948
21Thyroid cancer_Homo sapiens_hsa052161.53520270
22Alzheimers disease_Homo sapiens_hsa050101.52888150
23Amoebiasis_Homo sapiens_hsa051461.51983859
24Graft-versus-host disease_Homo sapiens_hsa053321.51439680
25Steroid biosynthesis_Homo sapiens_hsa001001.46070384
26Collecting duct acid secretion_Homo sapiens_hsa049661.40900593
27* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39133270
28Vibrio cholerae infection_Homo sapiens_hsa051101.29703853
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.27203879
30Prion diseases_Homo sapiens_hsa050201.26041592
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24442233
32Sphingolipid metabolism_Homo sapiens_hsa006001.21331813
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20400744
34Glioma_Homo sapiens_hsa052141.19616712
35Arachidonic acid metabolism_Homo sapiens_hsa005901.19290437
36Taste transduction_Homo sapiens_hsa047421.17348092
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15729060
38Phagosome_Homo sapiens_hsa041451.14744761
39Autoimmune thyroid disease_Homo sapiens_hsa053201.13758947
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12921192
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11974442
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11149576
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11075832
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09214202
45Serotonergic synapse_Homo sapiens_hsa047261.09110033
46* Jak-STAT signaling pathway_Homo sapiens_hsa046301.08550595
47Basal transcription factors_Homo sapiens_hsa030221.08469558
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06688505
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04824653
50VEGF signaling pathway_Homo sapiens_hsa043701.03910500
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01263677
52Axon guidance_Homo sapiens_hsa043601.00795171
53Fanconi anemia pathway_Homo sapiens_hsa034601.00773717
54Melanoma_Homo sapiens_hsa052181.00645299
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99273447
56Sulfur metabolism_Homo sapiens_hsa009200.98693041
57Adherens junction_Homo sapiens_hsa045200.97624121
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96676629
59Renal cell carcinoma_Homo sapiens_hsa052110.96383146
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95708801
61Allograft rejection_Homo sapiens_hsa053300.94571072
62Synaptic vesicle cycle_Homo sapiens_hsa047210.92693235
63Complement and coagulation cascades_Homo sapiens_hsa046100.92051801
64Prolactin signaling pathway_Homo sapiens_hsa049170.91549768
65Ether lipid metabolism_Homo sapiens_hsa005650.91526057
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90855033
67Phototransduction_Homo sapiens_hsa047440.90854917
68TGF-beta signaling pathway_Homo sapiens_hsa043500.89658907
69HIF-1 signaling pathway_Homo sapiens_hsa040660.89025336
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87775803
71Salmonella infection_Homo sapiens_hsa051320.85527436
72Apoptosis_Homo sapiens_hsa042100.85278689
73Proteasome_Homo sapiens_hsa030500.84178097
74Sulfur relay system_Homo sapiens_hsa041220.83804255
75Shigellosis_Homo sapiens_hsa051310.81708149
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79023352
77Prostate cancer_Homo sapiens_hsa052150.77654595
78Pancreatic cancer_Homo sapiens_hsa052120.76956807
79Bladder cancer_Homo sapiens_hsa052190.76609395
80Morphine addiction_Homo sapiens_hsa050320.75813670
81Pyrimidine metabolism_Homo sapiens_hsa002400.75747889
82Endometrial cancer_Homo sapiens_hsa052130.75563352
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75097788
84Melanogenesis_Homo sapiens_hsa049160.74875009
85Nicotine addiction_Homo sapiens_hsa050330.74800060
86Non-small cell lung cancer_Homo sapiens_hsa052230.73961282
87Asthma_Homo sapiens_hsa053100.72937067
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72820827
89Protein digestion and absorption_Homo sapiens_hsa049740.72786115
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72541715
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.72090170
92Gap junction_Homo sapiens_hsa045400.72069874
93Hedgehog signaling pathway_Homo sapiens_hsa043400.71965871
94Estrogen signaling pathway_Homo sapiens_hsa049150.71860167
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70214004
96Ovarian steroidogenesis_Homo sapiens_hsa049130.69612195
97Galactose metabolism_Homo sapiens_hsa000520.68325544
98Folate biosynthesis_Homo sapiens_hsa007900.68147151
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67204664
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66233492
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65245909
102Hepatitis B_Homo sapiens_hsa051610.65227112
103Wnt signaling pathway_Homo sapiens_hsa043100.65218898
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64601189
105Selenocompound metabolism_Homo sapiens_hsa004500.63689941
106Legionellosis_Homo sapiens_hsa051340.63262863
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.63160486
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62898861
109Glutamatergic synapse_Homo sapiens_hsa047240.60880502
110GnRH signaling pathway_Homo sapiens_hsa049120.60738938
111Rap1 signaling pathway_Homo sapiens_hsa040150.60544286
112Ras signaling pathway_Homo sapiens_hsa040140.59077029
113Endocytosis_Homo sapiens_hsa041440.58985880
114Pertussis_Homo sapiens_hsa051330.58571834
115TNF signaling pathway_Homo sapiens_hsa046680.58483756
116Purine metabolism_Homo sapiens_hsa002300.58261875
117Hippo signaling pathway_Homo sapiens_hsa043900.57731740
118Dilated cardiomyopathy_Homo sapiens_hsa054140.57212103
119Viral carcinogenesis_Homo sapiens_hsa052030.56840575
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.56838411
121Olfactory transduction_Homo sapiens_hsa047400.56411637
122MAPK signaling pathway_Homo sapiens_hsa040100.55912951
123Focal adhesion_Homo sapiens_hsa045100.55545495
124Acute myeloid leukemia_Homo sapiens_hsa052210.55263126
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55130248
126HTLV-I infection_Homo sapiens_hsa051660.54356811
127Pentose phosphate pathway_Homo sapiens_hsa000300.54223640
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53921824
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53634372
130Regulation of autophagy_Homo sapiens_hsa041400.52835408
131Cardiac muscle contraction_Homo sapiens_hsa042600.51811624
132Cholinergic synapse_Homo sapiens_hsa047250.51798574
133Fructose and mannose metabolism_Homo sapiens_hsa000510.51722222
134Proteoglycans in cancer_Homo sapiens_hsa052050.51319288
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50879381
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.50219627
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49524447
138Pathways in cancer_Homo sapiens_hsa052000.48816273
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47018567
140Basal cell carcinoma_Homo sapiens_hsa052170.46171504
141p53 signaling pathway_Homo sapiens_hsa041150.45884633
142Tuberculosis_Homo sapiens_hsa051520.45315048
143Homologous recombination_Homo sapiens_hsa034400.45085403
144Insulin secretion_Homo sapiens_hsa049110.44226176
145Alcoholism_Homo sapiens_hsa050340.43643419
146Tight junction_Homo sapiens_hsa045300.43013033
147ErbB signaling pathway_Homo sapiens_hsa040120.42739959
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.42545835
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36531268
150FoxO signaling pathway_Homo sapiens_hsa040680.35950262
151Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35630305
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.34625392
153Nucleotide excision repair_Homo sapiens_hsa034200.31823219
154Thyroid hormone synthesis_Homo sapiens_hsa049180.30546213
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30408665

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