IL12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.08475410
2ribosomal small subunit assembly (GO:0000028)6.79964033
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.06475194
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53925704
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.53925704
6negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.47418323
7positive regulation of B cell differentiation (GO:0045579)5.35711558
8proline metabolic process (GO:0006560)5.05268248
9regulation of B cell differentiation (GO:0045577)5.01738804
10antigen processing and presentation via MHC class Ib (GO:0002475)4.99289793
11viral transcription (GO:0019083)4.94824839
12antigen processing and presentation of endogenous antigen (GO:0019883)4.89529763
13positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.82198738
14lymphoid progenitor cell differentiation (GO:0002320)4.81630425
15DNA deamination (GO:0045006)4.67426317
16translational termination (GO:0006415)4.66478453
17regulation of RIG-I signaling pathway (GO:0039535)4.55022375
18immunoglobulin mediated immune response (GO:0016064)4.29799064
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.27885714
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22606241
21regulation of interferon-alpha production (GO:0032647)4.22092075
22telomere maintenance via semi-conservative replication (GO:0032201)4.18960812
23positive regulation of interferon-alpha production (GO:0032727)4.16690966
24response to interferon-beta (GO:0035456)4.13356981
25cotranslational protein targeting to membrane (GO:0006613)4.13077395
26protein targeting to ER (GO:0045047)4.09559029
27mast cell activation (GO:0045576)4.06352593
28glutamine family amino acid biosynthetic process (GO:0009084)4.04082732
29translational elongation (GO:0006414)4.02282032
30positive regulation of T-helper cell differentiation (GO:0045624)3.89633234
31protein localization to endoplasmic reticulum (GO:0070972)3.89084110
32platelet dense granule organization (GO:0060155)3.88463025
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.88221485
34cellular response to interferon-beta (GO:0035458)3.85193235
35DNA strand elongation (GO:0022616)3.85171079
36poly(A)+ mRNA export from nucleus (GO:0016973)3.84644197
37regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.83274402
38ribosomal small subunit biogenesis (GO:0042274)3.82198330
39DNA strand elongation involved in DNA replication (GO:0006271)3.81763796
402-deoxyribonucleotide biosynthetic process (GO:0009265)3.75510881
41deoxyribose phosphate biosynthetic process (GO:0046385)3.75510881
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66935463
43regulation of T-helper 1 cell differentiation (GO:0045625)3.59469163
44telomere maintenance via recombination (GO:0000722)3.57599293
45positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.53234924
46viral life cycle (GO:0019058)3.52054671
47cellular protein complex disassembly (GO:0043624)3.51972645
48positive regulation of gamma-delta T cell activation (GO:0046645)3.51211869
49negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.51046553
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50999380
51B cell receptor signaling pathway (GO:0050853)3.49152112
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46681502
53negative regulation of biomineral tissue development (GO:0070168)3.44425698
54regulation of histone H3-K9 methylation (GO:0051570)3.43346722
55B cell mediated immunity (GO:0019724)3.43190049
56maturation of SSU-rRNA (GO:0030490)3.39798997
57regulation of T-helper cell differentiation (GO:0045622)3.39193554
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.33510536
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32458744
60* defense response to protozoan (GO:0042832)3.26046332
61definitive hemopoiesis (GO:0060216)3.24094451
62regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.22603476
63mast cell degranulation (GO:0043303)3.22505957
64mast cell activation involved in immune response (GO:0002279)3.22505957
65mitotic recombination (GO:0006312)3.19948943
66thrombin receptor signaling pathway (GO:0070493)3.18124253
67angiogenesis involved in wound healing (GO:0060055)3.17496435
68translational initiation (GO:0006413)3.15982125
69protein complex disassembly (GO:0043241)3.15284139
70positive regulation of translational initiation (GO:0045948)3.13522876
71T cell homeostasis (GO:0043029)3.09511379
72neutrophil activation involved in immune response (GO:0002283)3.09358448
73negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.07135591
74DNA unwinding involved in DNA replication (GO:0006268)3.04275057
75telomere maintenance via telomere lengthening (GO:0010833)3.03610929
76positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.03230655
77regulation of histone phosphorylation (GO:0033127)3.02897764
78negative regulation of type I interferon production (GO:0032480)3.02005699
79positive regulation of alpha-beta T cell proliferation (GO:0046641)3.00497194
80regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00070417
81* response to protozoan (GO:0001562)2.99600430
82DNA replication initiation (GO:0006270)2.97850702
83negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97053281
84T-helper 1 type immune response (GO:0042088)2.96035124
85macromolecular complex disassembly (GO:0032984)2.95933918
86negative regulation of phagocytosis (GO:0050765)2.94950627
87positive regulation of interferon-beta production (GO:0032728)2.94545627
88maintenance of protein location in nucleus (GO:0051457)2.93843001
89leukocyte homeostasis (GO:0001776)2.93820613
90type I interferon signaling pathway (GO:0060337)2.93805808
91cellular response to type I interferon (GO:0071357)2.93805808
92protein import into peroxisome matrix (GO:0016558)2.92138455
93response to type I interferon (GO:0034340)2.89681176
94response to interferon-alpha (GO:0035455)2.89655138
95necrotic cell death (GO:0070265)2.89273414
96purine nucleotide salvage (GO:0032261)2.88962729
97neutrophil mediated immunity (GO:0002446)2.85238734
98CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84281250
99positive regulation of interleukin-17 production (GO:0032740)2.84083851
100negative regulation of erythrocyte differentiation (GO:0045647)2.83789020
101leukocyte degranulation (GO:0043299)2.83516484
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.83370108
103respiratory burst (GO:0045730)2.83173955
104regulation of interferon-beta production (GO:0032648)2.78261722
105megakaryocyte development (GO:0035855)2.77415094
106nuclear-transcribed mRNA catabolic process (GO:0000956)2.76289322
107basement membrane organization (GO:0071711)2.76284733
108mature B cell differentiation involved in immune response (GO:0002313)2.75782008
109negative regulation by host of viral transcription (GO:0043922)2.72776519
110ribosomal large subunit biogenesis (GO:0042273)2.72533759
111endosome to lysosome transport (GO:0008333)2.72010987
112relaxation of smooth muscle (GO:0044557)2.71993141
113seminiferous tubule development (GO:0072520)2.71780623
114positive regulation of granulocyte differentiation (GO:0030854)2.70747186
115regulation of MHC class II biosynthetic process (GO:0045346)2.70641101
116positive regulation of respiratory burst (GO:0060267)2.70577807
117protein targeting to membrane (GO:0006612)2.70044179
118positive regulation of macrophage differentiation (GO:0045651)2.68452612
119positive regulation of histone methylation (GO:0031062)2.67702098
120purine-containing compound salvage (GO:0043101)2.67580134
121necroptotic process (GO:0070266)2.67496587
122deoxyribonucleotide biosynthetic process (GO:0009263)2.66353339
123positive regulation of defense response to virus by host (GO:0002230)2.66049130
124regulation of cardioblast proliferation (GO:0003264)2.65889407
125regulation of secondary heart field cardioblast proliferation (GO:0003266)2.65889407
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.65050195
127regulation of T cell receptor signaling pathway (GO:0050856)2.64687373
128regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.64671731
129interferon-gamma-mediated signaling pathway (GO:0060333)2.64619665
130mRNA catabolic process (GO:0006402)2.64503915
131IMP metabolic process (GO:0046040)2.62831588
132fucose catabolic process (GO:0019317)2.62651399
133L-fucose metabolic process (GO:0042354)2.62651399
134L-fucose catabolic process (GO:0042355)2.62651399
135regulation of necroptotic process (GO:0060544)2.62590501
136regulation of interleukin-12 biosynthetic process (GO:0045075)2.62118395
137positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61772108
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60623315
139regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.60608940
140myeloid dendritic cell activation (GO:0001773)2.59894519
141cellular response to exogenous dsRNA (GO:0071360)2.59691695
142dendritic cell differentiation (GO:0097028)2.59175493
143cell migration involved in heart development (GO:0060973)2.58363782
144hemoglobin metabolic process (GO:0020027)2.57496949
145negative regulation of telomere maintenance (GO:0032205)2.57376798
146secretory granule organization (GO:0033363)2.56048733
147regulation of alpha-beta T cell proliferation (GO:0046640)2.55916275
148endosome to melanosome transport (GO:0035646)2.54512179
149endosome to pigment granule transport (GO:0043485)2.54512179
150negative regulation of myeloid cell apoptotic process (GO:0033033)2.54465676
151response to host immune response (GO:0052572)2.53412389
152response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53412389
153positive regulation of histone H3-K4 methylation (GO:0051571)2.53058519
154regulation of B cell apoptotic process (GO:0002902)2.52345589
155response to peptidoglycan (GO:0032494)2.51609105
156RNA catabolic process (GO:0006401)2.50889709
157lymphocyte homeostasis (GO:0002260)2.50867298
158nucleotide salvage (GO:0043173)2.49744290
159regulation of protein export from nucleus (GO:0046825)2.49424220
160lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48609670
161aggressive behavior (GO:0002118)2.47719045
162skin morphogenesis (GO:0043589)2.47174941
163programmed necrotic cell death (GO:0097300)2.47092156
164regulation of chronic inflammatory response (GO:0002676)2.47029232
165regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.46373255
166positive regulation of transcription factor import into nucleus (GO:0042993)2.43934740
167negative regulation of viral transcription (GO:0032897)2.43626409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12353685
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.60151789
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.13932385
4SCL_19346495_ChIP-Seq_HPC-7_Human3.72516105
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47164925
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.23875204
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21791047
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.01823909
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.98951649
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98602534
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95735887
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76421624
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.72264891
14* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.71785628
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64102453
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.59867887
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.55651331
18GATA1_22025678_ChIP-Seq_K562_Human2.48319790
19VDR_21846776_ChIP-Seq_THP-1_Human2.41031229
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38700675
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.32305678
22SPI1_23547873_ChIP-Seq_NB4_Human2.25696724
23MYC_22102868_ChIP-Seq_BL_Human2.24754347
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17500594
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12541610
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.11933841
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.09604279
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04599885
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02169379
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01882470
31VDR_24763502_ChIP-Seq_THP-1_Human1.98781346
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.97832376
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97351594
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96894667
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95303411
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93179762
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.90761899
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.87382850
39VDR_23849224_ChIP-Seq_CD4+_Human1.86068793
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85427426
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.83643863
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79594913
43MYB_26560356_Chip-Seq_TH2_Human1.78652853
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.76730117
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75553533
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75532172
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73593315
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72344362
49GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.72136985
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.71275002
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.68613106
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.68301428
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68176220
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66995806
55FOXP3_21729870_ChIP-Seq_TREG_Human1.66541509
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62332910
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61599156
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.60117665
59CIITA_25753668_ChIP-Seq_RAJI_Human1.59645415
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.59062951
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57102862
62MYB_26560356_Chip-Seq_TH1_Human1.56005031
63* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54660832
64ZNF263_19887448_ChIP-Seq_K562_Human1.52853060
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50552412
66MAF_26560356_Chip-Seq_TH1_Human1.50355738
67* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48791501
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48662404
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47602728
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46487796
71XRN2_22483619_ChIP-Seq_HELA_Human1.42194394
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41141856
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.41055136
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39046826
75* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37676554
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35531730
77UTX_26944678_Chip-Seq_JUKART_Human1.34983414
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33332581
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32984403
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32753930
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29579923
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28878721
83RUNX_20019798_ChIP-Seq_JUKART_Human1.28316610
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25022867
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24446167
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24010417
87* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23840767
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22901730
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21709436
90BRD4_25478319_ChIP-Seq_HGPS_Human1.17989552
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17798978
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.17223611
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.16981392
94TCF7_22412390_ChIP-Seq_EML_Mouse1.15195361
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.14912976
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12927228
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09695586
98SPI1_23127762_ChIP-Seq_K562_Human1.09131482
99GABP_19822575_ChIP-Seq_HepG2_Human1.07851106
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06894871
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05852125
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05585578
103DCP1A_22483619_ChIP-Seq_HELA_Human1.05515135
104ELK1_19687146_ChIP-ChIP_HELA_Human1.05071284
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04386397
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.03884900
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02078102
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01391434
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99526654
110MAF_26560356_Chip-Seq_TH2_Human0.99109229
111THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97768522
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97745988
113TTF2_22483619_ChIP-Seq_HELA_Human0.97657294
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96393003
115GATA3_27048872_Chip-Seq_THYMUS_Human0.96250696
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.95289930
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95170542
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94313658
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.93302315
120PU_27001747_Chip-Seq_BMDM_Mouse0.92729752
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92579819
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91676445
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.90396629
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87762442
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80550747
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80120197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.15347854
2MP0001835_abnormal_antigen_presentation4.53838818
3MP0009785_altered_susceptibility_to3.89381651
4MP0003283_abnormal_digestive_organ3.88085375
5MP0000685_abnormal_immune_system3.70821405
6MP0005503_abnormal_tendon_morphology3.38242676
7MP0005671_abnormal_response_to2.86290029
8MP0005623_abnormal_meninges_morphology2.80621087
9MP0005257_abnormal_intraocular_pressure2.76083901
10* MP0005025_abnormal_response_to2.66334227
11MP0002006_tumorigenesis2.66157638
12MP0001545_abnormal_hematopoietic_system2.57840042
13MP0005397_hematopoietic_system_phenotyp2.57840042
14MP0001800_abnormal_humoral_immune2.55685803
15* MP0002148_abnormal_hypersensitivity_rea2.54489090
16MP0005464_abnormal_platelet_physiology2.53787269
17MP0002419_abnormal_innate_immunity2.48955597
18* MP0005000_abnormal_immune_tolerance2.44264228
19MP0002452_abnormal_antigen_presenting2.43123545
20* MP0002723_abnormal_immune_serum2.41813566
21MP0008007_abnormal_cellular_replicative2.41748903
22MP0003763_abnormal_thymus_physiology2.39184729
23* MP0002420_abnormal_adaptive_immunity2.38697141
24MP0002398_abnormal_bone_marrow2.36098681
25MP0003724_increased_susceptibility_to2.34868735
26* MP0001819_abnormal_immune_cell2.33963868
27MP0004808_abnormal_hematopoietic_stem2.32939288
28MP0002166_altered_tumor_susceptibility2.26805587
29MP0003436_decreased_susceptibility_to2.18450095
30MP0002877_abnormal_melanocyte_morpholog2.17917203
31MP0005275_abnormal_skin_tensile2.07159824
32MP0000716_abnormal_immune_system2.06718662
33MP0000689_abnormal_spleen_morphology2.06689835
34MP0001790_abnormal_immune_system1.99201236
35MP0005387_immune_system_phenotype1.99201236
36MP0005174_abnormal_tail_pigmentation1.98074230
37MP0008004_abnormal_stomach_pH1.97929575
38MP0005508_abnormal_skeleton_morphology1.97822900
39MP0008438_abnormal_cutaneous_collagen1.93359332
40MP0005390_skeleton_phenotype1.92013642
41MP0004883_abnormal_blood_vessel1.90356703
42MP0002429_abnormal_blood_cell1.89803906
43MP0001853_heart_inflammation1.88904611
44MP0010094_abnormal_chromosome_stability1.88881790
45MP0008057_abnormal_DNA_replication1.87717420
46MP0002722_abnormal_immune_system1.86797514
47MP0005075_abnormal_melanosome_morpholog1.83566896
48MP0010155_abnormal_intestine_physiology1.82457193
49MP0000490_abnormal_crypts_of1.74086303
50MP0000465_gastrointestinal_hemorrhage1.73648719
51MP0009278_abnormal_bone_marrow1.69150371
52MP0003448_altered_tumor_morphology1.68528068
53MP0001542_abnormal_bone_strength1.67867401
54MP0001873_stomach_inflammation1.67546989
55MP0009333_abnormal_splenocyte_physiolog1.65607796
56MP0002163_abnormal_gland_morphology1.64472571
57MP0001845_abnormal_inflammatory_respons1.62680120
58MP0005164_abnormal_response_to1.60535486
59MP0009250_abnormal_appendicular_skeleto1.60204756
60MP0003693_abnormal_embryo_hatching1.58812389
61* MP0002405_respiratory_system_inflammati1.54033600
62MP0003279_aneurysm1.53076330
63MP0008058_abnormal_DNA_repair1.52246793
64MP0009379_abnormal_foot_pigmentation1.49280918
65MP0002095_abnormal_skin_pigmentation1.47915573
66MP0009697_abnormal_copulation1.45058625
67* MP0008469_abnormal_protein_level1.44785367
68MP0003183_abnormal_peptide_metabolism1.43378269
69MP0001986_abnormal_taste_sensitivity1.39714264
70MP0006082_CNS_inflammation1.39666679
71MP0000703_abnormal_thymus_morphology1.39157181
72MP0003866_abnormal_defecation1.36635836
73MP0006054_spinal_hemorrhage1.34729915
74MP0001346_abnormal_lacrimal_gland1.30802339
75MP0003077_abnormal_cell_cycle1.28477445
76* MP0002019_abnormal_tumor_incidence1.27341227
77MP0004947_skin_inflammation1.26602683
78MP0006292_abnormal_olfactory_placode1.25408138
79MP0000343_altered_response_to1.21848566
80MP0001188_hyperpigmentation1.19867876
81MP0004147_increased_porphyrin_level1.17074283
82MP0000858_altered_metastatic_potential1.14101745
83MP0005023_abnormal_wound_healing1.10587360
84MP0001243_abnormal_dermal_layer1.09304745
85MP0000249_abnormal_blood_vessel1.07847279
86MP0002998_abnormal_bone_remodeling1.07701207
87MP0003315_abnormal_perineum_morphology1.06803554
88MP0000678_abnormal_parathyroid_gland1.05363473
89MP0003091_abnormal_cell_migration1.03403554
90MP0004957_abnormal_blastocyst_morpholog1.01740047
91MP0004134_abnormal_chest_morphology1.01491763
92MP0002160_abnormal_reproductive_system1.00177466
93MP0000015_abnormal_ear_pigmentation0.97936430
94MP0006036_abnormal_mitochondrial_physio0.97517818
95MP0005646_abnormal_pituitary_gland0.95620872
96MP0009764_decreased_sensitivity_to0.93870708
97MP0003656_abnormal_erythrocyte_physiolo0.92554102
98MP0003111_abnormal_nucleus_morphology0.90700508
99MP0005165_increased_susceptibility_to0.90064112
100MP0001348_abnormal_lacrimal_gland0.89754328
101MP0003075_altered_response_to0.89441537
102MP0000516_abnormal_urinary_system0.88330570
103MP0005367_renal/urinary_system_phenotyp0.88330570
104MP0002254_reproductive_system_inflammat0.88093507
105MP0010352_gastrointestinal_tract_polyps0.87348697
106MP0000371_diluted_coat_color0.87193383
107MP0005409_darkened_coat_color0.87182402
108MP0003303_peritoneal_inflammation0.86465132
109MP0001533_abnormal_skeleton_physiology0.86159959
110MP0003186_abnormal_redox_activity0.86038237
111MP0003828_pulmonary_edema0.82528357
112MP0002108_abnormal_muscle_morphology0.82496095
113* MP0009765_abnormal_xenobiotic_induced0.82305719
114MP0000313_abnormal_cell_death0.80930930
115MP0005058_abnormal_lysosome_morphology0.77896045
116MP0002113_abnormal_skeleton_development0.76747811
117MP0000681_abnormal_thyroid_gland0.75360111
118MP0001663_abnormal_digestive_system0.73948441
119MP0008874_decreased_physiological_sensi0.73271926
120MP0005310_abnormal_salivary_gland0.73194233
121MP0003786_premature_aging0.72363893
122MP0003646_muscle_fatigue0.71949816
123MP0002114_abnormal_axial_skeleton0.71385110
124MP0002060_abnormal_skin_morphology0.70275755
125MP0002933_joint_inflammation0.69671729
126MP0005084_abnormal_gallbladder_morpholo0.69121331
127MP0003795_abnormal_bone_structure0.68701170
128MP0003943_abnormal_hepatobiliary_system0.66820228
129MP0003806_abnormal_nucleotide_metabolis0.66736590
130MP0001764_abnormal_homeostasis0.66330870
131* MP0009763_increased_sensitivity_to0.65994617
132MP0003191_abnormal_cellular_cholesterol0.65344014
133MP0000749_muscle_degeneration0.64428074
134MP0002132_abnormal_respiratory_system0.63941522
135MP0005621_abnormal_cell_physiology0.63312550
136MP0002075_abnormal_coat/hair_pigmentati0.63273747
137MP0005584_abnormal_enzyme/coenzyme_acti0.60556545
138MP0002928_abnormal_bile_duct0.60346521
139MP0003172_abnormal_lysosome_physiology0.59809266
140MP0000372_irregular_coat_pigmentation0.59657264
141MP0004510_myositis0.58612329
142MP0000350_abnormal_cell_proliferation0.51126135
143MP0002876_abnormal_thyroid_physiology0.48161912
144MP0000598_abnormal_liver_morphology0.48007750

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.73643699
2Elevated erythrocyte sedimentation rate (HP:0003565)5.46115579
3Chronic otitis media (HP:0000389)5.41705637
4Absent frontal sinuses (HP:0002688)5.35127408
5Recurrent bacterial skin infections (HP:0005406)5.23332559
6Thrombocytosis (HP:0001894)5.14404588
7Spondylolisthesis (HP:0003302)5.12559100
8Myositis (HP:0100614)5.08526684
9Aplastic anemia (HP:0001915)4.97709164
10Short middle phalanx of the 5th finger (HP:0004220)4.97370071
11Metaphyseal dysplasia (HP:0100255)4.79572124
12IgM deficiency (HP:0002850)4.77766349
13Acute lymphatic leukemia (HP:0006721)4.25885451
14Abnormality of cells of the erythroid lineage (HP:0012130)4.09300307
15Abnormal number of erythroid precursors (HP:0012131)4.05634334
16Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.99138241
17Constricted visual fields (HP:0001133)3.98005548
18Reticulocytopenia (HP:0001896)3.84649921
19Scanning speech (HP:0002168)3.78496796
20Panhypogammaglobulinemia (HP:0003139)3.71547608
21Recurrent bronchitis (HP:0002837)3.62894385
22Eczematoid dermatitis (HP:0000976)3.62546473
23Mediastinal lymphadenopathy (HP:0100721)3.52145823
24Recurrent skin infections (HP:0001581)3.46199529
25Meningitis (HP:0001287)3.42511587
26Recurrent viral infections (HP:0004429)3.40795140
27Abnormality of macrophages (HP:0004311)3.40531606
28Cellulitis (HP:0100658)3.32906367
29Agammaglobulinemia (HP:0004432)3.32683621
30Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.31914691
31Syringomyelia (HP:0003396)3.30506264
32Spinal cord lesions (HP:0100561)3.30506264
33Abnormality of B cell number (HP:0010975)3.29086309
34B lymphocytopenia (HP:0010976)3.29086309
35Abnormality of the frontal sinuses (HP:0002687)3.28307602
36Petechiae (HP:0000967)3.26729112
37Colon cancer (HP:0003003)3.22962896
38Acute myeloid leukemia (HP:0004808)3.10033702
39Recurrent fungal infections (HP:0002841)3.08932495
40Abnormality of T cell physiology (HP:0011840)3.05600817
41Genetic anticipation (HP:0003743)3.01149332
42Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.94686481
43Abnormality of the parietal bone (HP:0002696)2.89075592
44Interstitial pulmonary disease (HP:0006530)2.89062143
45Type I transferrin isoform profile (HP:0003642)2.84423342
46Prolonged bleeding time (HP:0003010)2.83758159
47Thyroiditis (HP:0100646)2.81006300
48Abnormality of glycolipid metabolism (HP:0010969)2.79820846
49Abnormality of liposaccharide metabolism (HP:0010968)2.79820846
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.79820846
51Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.78740584
52Nonimmune hydrops fetalis (HP:0001790)2.78652333
53Reduced antithrombin III activity (HP:0001976)2.76754725
54Recurrent gram-negative bacterial infections (HP:0005420)2.76415117
55Colitis (HP:0002583)2.73733770
56Nasal polyposis (HP:0100582)2.72993610
57IgG deficiency (HP:0004315)2.70971019
58Obstructive lung disease (HP:0006536)2.66925793
59Chronic obstructive pulmonary disease (HP:0006510)2.66925793
60Decreased skull ossification (HP:0004331)2.64182548
61Slow saccadic eye movements (HP:0000514)2.62685763
62Irregular vertebral endplates (HP:0003301)2.61520921
63Gastrointestinal stroma tumor (HP:0100723)2.61018034
64Hypoplasia of the thymus (HP:0000778)2.59601276
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.58970924
66Recurrent cutaneous fungal infections (HP:0011370)2.56606983
67Chronic mucocutaneous candidiasis (HP:0002728)2.56606983
68Lymphoma (HP:0002665)2.56316197
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.55920585
70Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.55496730
71Chronic sinusitis (HP:0011109)2.53624448
72Cupped ribs (HP:0000887)2.53224712
73Lymphopenia (HP:0001888)2.53076950
74Poikiloderma (HP:0001029)2.52424059
75Gastrointestinal inflammation (HP:0004386)2.51489052
76Abnormality of macular pigmentation (HP:0008002)2.51357451
77Inflammation of the large intestine (HP:0002037)2.49928571
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.48845389
79Recurrent sinusitis (HP:0011108)2.48122196
80Pallor (HP:0000980)2.47783019
81Epistaxis (HP:0000421)2.47497074
82Abnormality of the phalanges of the 5th finger (HP:0004213)2.46288362
83Muscle stiffness (HP:0003552)2.45816434
84Hypoproteinemia (HP:0003075)2.43783848
85Abnormality of T cells (HP:0002843)2.42288934
86Abnormality of the nasal mucosa (HP:0000433)2.40475598
87Vasculitis (HP:0002633)2.37372211
88Abnormality of skull ossification (HP:0002703)2.35836929
89Retrobulbar optic neuritis (HP:0100654)2.34299760
90Optic neuritis (HP:0100653)2.34299760
91Oral leukoplakia (HP:0002745)2.33220689
92Orchitis (HP:0100796)2.32691101
93Macrocytic anemia (HP:0001972)2.32492741
94Delayed closure of the anterior fontanelle (HP:0001476)2.31553129
95Dysmetric saccades (HP:0000641)2.31516527
96Abnormality of the heme biosynthetic pathway (HP:0010472)2.30897244
97Aplasia of the musculature (HP:0100854)2.27536759
98Recurrent pneumonia (HP:0006532)2.26012892
99Enlarged epiphyses (HP:0010580)2.24522157
100Type 2 muscle fiber atrophy (HP:0003554)2.23826435
101Increased mean platelet volume (HP:0011877)2.23593479
102Abnormal rod and cone electroretinograms (HP:0008323)2.23437570
103Encephalitis (HP:0002383)2.22749717
104Abnormal platelet volume (HP:0011876)2.20558842
105Partial duplication of the phalanx of hand (HP:0009999)2.20163804
106Radial bowing (HP:0002986)2.19312281
107Muscle fiber atrophy (HP:0100295)2.18804272
108Abnormal protein glycosylation (HP:0012346)2.18064142
109Abnormal glycosylation (HP:0012345)2.18064142
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18064142
111Abnormal protein N-linked glycosylation (HP:0012347)2.18064142
112Osteomyelitis (HP:0002754)2.15933587
113Abnormality of the vertebral endplates (HP:0005106)2.15506809
114Polygenic inheritance (HP:0010982)2.14818761
115Abnormality of the prostate (HP:0008775)2.14793556
116Metaphyseal cupping (HP:0003021)2.11860230
11711 pairs of ribs (HP:0000878)2.11703782
118Spontaneous hematomas (HP:0007420)2.11273467
119Recurrent lower respiratory tract infections (HP:0002783)2.10736889
120Agnosia (HP:0010524)2.09816522
121Bronchitis (HP:0012387)2.09288915
122Absent thumb (HP:0009777)2.09022840
123Pancytopenia (HP:0001876)2.08527212
124Bulbar palsy (HP:0001283)2.08362825
125Autoimmune hemolytic anemia (HP:0001890)2.08161972
126Ulnar bowing (HP:0003031)2.06758258
127Flattened epiphyses (HP:0003071)2.06687289
128Muscle hypertrophy of the lower extremities (HP:0008968)2.04841652
129Coxa vara (HP:0002812)2.04281523
130Brushfield spots (HP:0001088)2.04065595
131Delayed cranial suture closure (HP:0000270)2.02792253
132Dyschromatopsia (HP:0007641)2.02118851
133Hypoplastic left heart (HP:0004383)2.01509301
134Short clavicles (HP:0000894)2.01239574
135Squamous cell carcinoma (HP:0002860)2.00998937
136Esophageal neoplasm (HP:0100751)2.00043398
137Neoplasm of head and neck (HP:0012288)2.00043398
138Sepsis (HP:0100806)1.99402644
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98420136
140Patent foramen ovale (HP:0001655)1.98366080
141Abnormality of the distal phalanges of the toes (HP:0010182)1.98184095
142Erythema (HP:0010783)1.97340310
143Femoral bowing (HP:0002980)1.97310085
144Myelodysplasia (HP:0002863)1.97270031
145Microcytic anemia (HP:0001935)1.95360003
146Keratoconjunctivitis (HP:0001096)1.94142523
147Attenuation of retinal blood vessels (HP:0007843)1.94048734
148Hepatocellular necrosis (HP:0001404)1.93230295
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91157137
150Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91157137
151Abnormality of the columella (HP:0009929)1.90955602
152Poor head control (HP:0002421)1.90955197
153Hypergammaglobulinemia (HP:0010702)1.90008450
154Stomatitis (HP:0010280)1.89856131
155Gingivitis (HP:0000230)1.89391248
156Hypertensive crisis (HP:0100735)1.87920545
157Exertional dyspnea (HP:0002875)1.84660846
158Myotonia (HP:0002486)1.84645796
159Skin rash (HP:0000988)1.83633829
160Neutropenia (HP:0001875)1.83405890
161Keratoconjunctivitis sicca (HP:0001097)1.82983935
162Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82469067
163Vertebral hypoplasia (HP:0008417)1.82469067
164Short 5th finger (HP:0009237)1.81976455
165Abnormal hemoglobin (HP:0011902)1.81330643
166Chronic diarrhea (HP:0002028)1.80489865
167Broad distal phalanx of finger (HP:0009836)1.78505231
168Protrusio acetabuli (HP:0003179)1.77083912
169Abnormality of the 2nd finger (HP:0004100)1.74114030
170Sparse lateral eyebrow (HP:0005338)1.73780567
171Renal cortical cysts (HP:0000803)1.71877857
172Cone-rod dystrophy (HP:0000548)1.71044139
173Tibial bowing (HP:0002982)1.69947807
174Aortic aneurysm (HP:0004942)1.68083580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT36.23858456
2KIT5.21891886
3CSF1R3.36606958
4MAP4K12.81397205
5ADRBK22.75551091
6NME22.65975624
7IRAK42.57310198
8TEC2.56157118
9RIPK42.52339931
10PBK2.35357802
11TNIK2.24353325
12PRPF4B2.22849015
13BTK2.19888258
14MAP3K122.16695718
15STK162.10503056
16PIM22.04802008
17CCNB12.01670919
18WEE11.94449615
19BLK1.89538117
20ILK1.84445053
21TBK11.76584706
22IRAK11.63670975
23CDK191.62014201
24SYK1.58731764
25SCYL21.56073220
26GRK71.39875049
27EEF2K1.38695491
28JAK11.37918042
29IKBKE1.31501301
30TAOK21.29533070
31ABL21.25916925
32NLK1.25855895
33FES1.24409575
34TXK1.22987794
35MAP2K31.21631227
36BRSK21.20897298
37CDC71.20567262
38VRK11.20258861
39MATK1.18553903
40TGFBR11.14317633
41LYN1.11532072
42JAK31.10862616
43MUSK1.06957088
44MAP3K141.03989742
45ACVR1B1.03502326
46DYRK31.01254438
47RPS6KB20.98499053
48EIF2AK30.98115544
49ZAP700.97403981
50RPS6KA40.97291415
51NUAK10.96010690
52IKBKB0.94579732
53BUB10.94524679
54TYK20.94306146
55TAOK30.94078733
56LRRK20.93282350
57STK100.92883215
58LCK0.91642481
59PAK20.89438316
60PRKCH0.89271668
61CDK30.84591523
62CLK10.83563189
63MAP3K60.83053900
64MOS0.83024482
65PIM10.80850730
66EIF2AK10.78791714
67MKNK10.76218434
68GSK3A0.75454776
69KDR0.74757856
70OXSR10.73877624
71PRKD20.73785630
72YES10.71372588
73CDK70.70809313
74PASK0.69881062
75DDR20.69863986
76RAF10.68266414
77MAP3K110.66057898
78PRKD30.65154933
79IRAK30.64843097
80MAPKAPK50.64143549
81BCKDK0.64075017
82MAP3K130.62991182
83TSSK60.61976471
84RPS6KA50.61594214
85CAMKK20.61496730
86ATR0.60185700
87MAP3K30.59857182
88DAPK10.59755501
89ITK0.59647713
90HCK0.59440706
91PDPK10.58790297
92MAPKAPK30.57791758
93BMPR20.57383210
94PRKCQ0.56643676
95MAPK40.56478644
96MAP2K40.56252281
97GRK60.55323237
98PDK10.53315146
99TLK10.52672291
100MAP3K10.50873218
101MAPK110.49650082
102MAP3K50.49079652
103MAPK150.48829750
104BRD40.47809543
105MARK30.47133313
106CDK40.44801429
107TESK20.43367763
108BRSK10.43306091
109PKN20.43074651
110VRK20.42478751
111MAP2K60.42249192
112DAPK30.41939578
113NEK10.41522007
114MAP3K100.41364897
115ALK0.41045516
116CDK80.40709021
117MAPK70.40212249
118PRKG20.39752442
119CDK60.39047716
120MAPKAPK20.38659654
121IRAK20.38459701
122CAMK10.38147397
123ABL10.38125747
124BMPR1B0.37434262
125RPS6KA60.37124165
126STK40.36546777
127MYLK0.34461561
128MKNK20.33873846
129SRPK10.32532960
130TRPM70.29163264
131NEK20.28660531
132CHUK0.28515062
133TNK20.27712618
134CSK0.26468795
135PRKCD0.25146906
136EIF2AK20.24996133
137RPS6KC10.24686029
138RPS6KL10.24686029
139AURKB0.24446904
140ERN10.23367896

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62663151
2Ribosome_Homo sapiens_hsa030104.07223606
3Mismatch repair_Homo sapiens_hsa034303.41499634
4Non-homologous end-joining_Homo sapiens_hsa034503.24665939
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.17047165
6Primary immunodeficiency_Homo sapiens_hsa053402.85204171
7Base excision repair_Homo sapiens_hsa034102.78310002
8Homologous recombination_Homo sapiens_hsa034402.50518082
9Hematopoietic cell lineage_Homo sapiens_hsa046402.33565860
10* Leishmaniasis_Homo sapiens_hsa051402.16774501
11Autoimmune thyroid disease_Homo sapiens_hsa053202.11750448
12Pyrimidine metabolism_Homo sapiens_hsa002402.02776381
13* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80023505
14Nucleotide excision repair_Homo sapiens_hsa034201.78154219
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.78047843
16B cell receptor signaling pathway_Homo sapiens_hsa046621.75783163
17RNA polymerase_Homo sapiens_hsa030201.75096671
18* Legionellosis_Homo sapiens_hsa051341.70452412
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61718903
20* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61246921
21* Herpes simplex infection_Homo sapiens_hsa051681.59914031
22Antigen processing and presentation_Homo sapiens_hsa046121.58993385
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58605515
24Spliceosome_Homo sapiens_hsa030401.53185000
25Folate biosynthesis_Homo sapiens_hsa007901.52283663
26Proteasome_Homo sapiens_hsa030501.50776834
27* Measles_Homo sapiens_hsa051621.47224371
28Graft-versus-host disease_Homo sapiens_hsa053321.38557819
29* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38449679
30Protein export_Homo sapiens_hsa030601.36767908
31* Pertussis_Homo sapiens_hsa051331.33505438
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.31657052
33Osteoclast differentiation_Homo sapiens_hsa043801.30101095
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29065781
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23830710
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20925381
37Acute myeloid leukemia_Homo sapiens_hsa052211.19412479
38Pentose phosphate pathway_Homo sapiens_hsa000301.17188850
39N-Glycan biosynthesis_Homo sapiens_hsa005101.15529670
40Salmonella infection_Homo sapiens_hsa051321.13902447
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12020251
42Fanconi anemia pathway_Homo sapiens_hsa034601.08234847
43* Influenza A_Homo sapiens_hsa051641.07072666
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05133374
45RNA degradation_Homo sapiens_hsa030181.04824561
46* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02945161
47Cell cycle_Homo sapiens_hsa041101.01203371
48Purine metabolism_Homo sapiens_hsa002301.00538062
49* Tuberculosis_Homo sapiens_hsa051520.96069735
50Glutathione metabolism_Homo sapiens_hsa004800.95985839
51Shigellosis_Homo sapiens_hsa051310.92850331
52* Jak-STAT signaling pathway_Homo sapiens_hsa046300.92276038
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89086113
54Systemic lupus erythematosus_Homo sapiens_hsa053220.85232382
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84630950
56Other glycan degradation_Homo sapiens_hsa005110.83908724
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80224763
58Sulfur relay system_Homo sapiens_hsa041220.79986974
59Hepatitis B_Homo sapiens_hsa051610.79166740
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78838992
61Staphylococcus aureus infection_Homo sapiens_hsa051500.78361511
62Asthma_Homo sapiens_hsa053100.78349772
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77391405
64* Malaria_Homo sapiens_hsa051440.76932817
65One carbon pool by folate_Homo sapiens_hsa006700.76169970
66Prolactin signaling pathway_Homo sapiens_hsa049170.76067206
67Platelet activation_Homo sapiens_hsa046110.75453938
68Epstein-Barr virus infection_Homo sapiens_hsa051690.72668760
69Selenocompound metabolism_Homo sapiens_hsa004500.72352220
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71706098
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70792206
72p53 signaling pathway_Homo sapiens_hsa041150.70049254
73Pancreatic cancer_Homo sapiens_hsa052120.69523102
74TNF signaling pathway_Homo sapiens_hsa046680.63691053
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.63248135
76VEGF signaling pathway_Homo sapiens_hsa043700.61130224
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61031243
78RNA transport_Homo sapiens_hsa030130.60705078
79Apoptosis_Homo sapiens_hsa042100.59514484
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.58654191
81Chemokine signaling pathway_Homo sapiens_hsa040620.57377651
82* Amoebiasis_Homo sapiens_hsa051460.55858847
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55681995
84Circadian rhythm_Homo sapiens_hsa047100.55283839
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53749505
86mTOR signaling pathway_Homo sapiens_hsa041500.52900446
87* Toxoplasmosis_Homo sapiens_hsa051450.52808372
88Insulin resistance_Homo sapiens_hsa049310.52608184
89Mineral absorption_Homo sapiens_hsa049780.51909268
90Rheumatoid arthritis_Homo sapiens_hsa053230.51169677
91* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46328493
92* Type I diabetes mellitus_Homo sapiens_hsa049400.44750799
93Viral carcinogenesis_Homo sapiens_hsa052030.44572531
94Lysosome_Homo sapiens_hsa041420.44061896
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43454547
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.43369362
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42933365
98Proteoglycans in cancer_Homo sapiens_hsa052050.41615067
99* African trypanosomiasis_Homo sapiens_hsa051430.40688288
100Basal transcription factors_Homo sapiens_hsa030220.39641679
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.39559439
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38155222
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36260540
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36122005
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35306275
106Bladder cancer_Homo sapiens_hsa052190.34176238
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34095254
108Small cell lung cancer_Homo sapiens_hsa052220.33744757
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.33708454
110Thyroid cancer_Homo sapiens_hsa052160.33468229
111HTLV-I infection_Homo sapiens_hsa051660.31940611
112Viral myocarditis_Homo sapiens_hsa054160.29536375
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.29516458
114Chronic myeloid leukemia_Homo sapiens_hsa052200.29458158
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28572957
116Caffeine metabolism_Homo sapiens_hsa002320.28296225
117Hepatitis C_Homo sapiens_hsa051600.27923326
118T cell receptor signaling pathway_Homo sapiens_hsa046600.27484280
119Galactose metabolism_Homo sapiens_hsa000520.26778069
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26096080
121Peroxisome_Homo sapiens_hsa041460.25269384
122Non-small cell lung cancer_Homo sapiens_hsa052230.25045253
123* Allograft rejection_Homo sapiens_hsa053300.24050177
124Melanoma_Homo sapiens_hsa052180.23396555
125FoxO signaling pathway_Homo sapiens_hsa040680.20576821
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19263089
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.17565147

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