IL12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of activation of Janus kinase activity (GO:0010533)9.35141154
2regulation of vitamin D biosynthetic process (GO:0060556)6.50616233
3* negative regulation of interleukin-10 production (GO:0032693)6.37566003
4* positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.18669379
5* positive regulation of T-helper cell differentiation (GO:0045624)6.15616449
6kynurenine metabolic process (GO:0070189)6.04500003
7indole-containing compound catabolic process (GO:0042436)5.83212740
8indolalkylamine catabolic process (GO:0046218)5.83212740
9tryptophan catabolic process (GO:0006569)5.83212740
10regulation of T-helper 2 cell differentiation (GO:0045628)5.68893965
11* positive regulation of interleukin-12 production (GO:0032735)5.46011411
12* regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.45823436
13positive regulation of type 2 immune response (GO:0002830)5.44734142
14regulation of immunoglobulin secretion (GO:0051023)5.41017264
15* regulation of memory T cell differentiation (GO:0043380)5.39342577
16regulation of T-helper 1 cell differentiation (GO:0045625)5.38212900
17* T-helper 1 type immune response (GO:0042088)5.19053011
18* positive regulation of alpha-beta T cell proliferation (GO:0046641)5.07961596
19* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.07462637
20regulation of vitamin metabolic process (GO:0030656)5.06180493
21* positive regulation of NF-kappaB import into nucleus (GO:0042346)4.95140616
22positive regulation of neutrophil migration (GO:1902624)4.93721656
23positive regulation of neutrophil chemotaxis (GO:0090023)4.93721656
24positive regulation of natural killer cell differentiation (GO:0032825)4.82403099
25* regulation of T-helper cell differentiation (GO:0045622)4.79304742
26type I interferon signaling pathway (GO:0060337)4.70236010
27cellular response to type I interferon (GO:0071357)4.70236010
28positive regulation of interferon-alpha production (GO:0032727)4.69622229
29regulation of T cell tolerance induction (GO:0002664)4.68945823
30regulation of RIG-I signaling pathway (GO:0039535)4.64352864
31* regulation of alpha-beta T cell proliferation (GO:0046640)4.62395553
32natural killer cell mediated cytotoxicity (GO:0042267)4.62346792
33natural killer cell mediated immunity (GO:0002228)4.62346792
34tryptophan metabolic process (GO:0006568)4.62140299
35response to type I interferon (GO:0034340)4.62104318
36positive regulation of heat generation (GO:0031652)4.61569283
37response to peptidoglycan (GO:0032494)4.56868764
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.43574657
39regulation of fever generation (GO:0031620)4.41767334
40regulation of interferon-alpha production (GO:0032647)4.37469283
41* positive regulation of interleukin-17 production (GO:0032740)4.34506140
42positive regulation of granulocyte chemotaxis (GO:0071624)4.32883318
43negative regulation of interleukin-12 production (GO:0032695)4.29805256
44positive regulation of monocyte chemotaxis (GO:0090026)4.28820743
45* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.24213830
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18426404
47neutrophil activation involved in immune response (GO:0002283)4.15355830
48regulation of neutrophil chemotaxis (GO:0090022)4.14364228
49regulation of neutrophil migration (GO:1902622)4.14364228
50eosinophil chemotaxis (GO:0048245)4.13474961
51regulation of interleukin-12 biosynthetic process (GO:0045075)4.13187032
52* regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.12923341
53* regulation of interleukin-10 production (GO:0032653)4.12231866
54cellular biogenic amine catabolic process (GO:0042402)4.07688287
55amine catabolic process (GO:0009310)4.07688287
56monocyte chemotaxis (GO:0002548)4.06398445
57* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.04781315
58* regulation of interleukin-12 production (GO:0032655)3.99445911
59regulation of hypersensitivity (GO:0002883)3.98156894
60regulation of tolerance induction (GO:0002643)3.96339622
61myeloid dendritic cell differentiation (GO:0043011)3.95791818
62granulocyte activation (GO:0036230)3.95148541
63neutrophil activation (GO:0042119)3.91379616
64natural killer cell differentiation (GO:0001779)3.91076966
65positive regulation of tolerance induction (GO:0002645)3.90227212
66* regulation of alpha-beta T cell differentiation (GO:0046637)3.89502324
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88902999
68regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.88813947
69production of molecular mediator involved in inflammatory response (GO:0002532)3.88344235
70positive regulation of cAMP-mediated signaling (GO:0043950)3.88307025
71antigen processing and presentation of endogenous antigen (GO:0019883)3.72742651
72* defense response to protozoan (GO:0042832)3.72159612
73regulation of antigen processing and presentation (GO:0002577)3.71999434
74regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.71815423
75negative regulation of viral genome replication (GO:0045071)3.68199283
76regulation of chemokine biosynthetic process (GO:0045073)3.67113563
77lipopolysaccharide-mediated signaling pathway (GO:0031663)3.66671934
78regulation of heat generation (GO:0031650)3.65854502
79eosinophil migration (GO:0072677)3.63758285
80positive regulation of T cell cytokine production (GO:0002726)3.61998961
81* regulation of T-helper 1 type immune response (GO:0002825)3.60595733
82positive regulation of interleukin-2 production (GO:0032743)3.59294741
83* positive regulation of activated T cell proliferation (GO:0042104)3.58893367
84cellular response to ATP (GO:0071318)3.58233195
85positive regulation of Cdc42 GTPase activity (GO:0043089)3.55795102
86* regulation of NF-kappaB import into nucleus (GO:0042345)3.52340421
87* regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.52249254
88* positive regulation of T-helper 1 type immune response (GO:0002827)3.51917393
89leukocyte mediated cytotoxicity (GO:0001909)3.50183540
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.48967040
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.47494588
92myeloid dendritic cell activation (GO:0001773)3.47478159
93regulation of granulocyte chemotaxis (GO:0071622)3.46787607
94indolalkylamine metabolic process (GO:0006586)3.46476204
95* regulation of interleukin-17 production (GO:0032660)3.43136784
96interferon-gamma-mediated signaling pathway (GO:0060333)3.42895331
97* positive regulation of alpha-beta T cell activation (GO:0046635)3.41529300
98* regulation of natural killer cell activation (GO:0032814)3.41300659
99cellular response to interferon-alpha (GO:0035457)3.40968008
100* positive regulation of defense response to virus by host (GO:0002230)3.40484684
101fat-soluble vitamin biosynthetic process (GO:0042362)3.40123384
102CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.38235808
103response to interferon-alpha (GO:0035455)3.37345658
104* regulation of alpha-beta T cell activation (GO:0046634)3.36823520
105immunoglobulin mediated immune response (GO:0016064)3.35887097
106regulation of interleukin-1 beta secretion (GO:0050706)3.35787941
107* regulation of T cell mediated cytotoxicity (GO:0001914)3.34585564
108* positive regulation of interleukin-10 production (GO:0032733)3.31477219
109* positive regulation of T cell proliferation (GO:0042102)3.30547614
110* positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29218637
111positive regulation of antigen processing and presentation (GO:0002579)3.26734381
112regulation of chemokine-mediated signaling pathway (GO:0070099)3.26435983
113* positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.24717178
114* positive regulation of alpha-beta T cell differentiation (GO:0046638)3.24568005
115* positive regulation of osteoclast differentiation (GO:0045672)3.24484629
116cellular response to virus (GO:0098586)3.23200034
117antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23191482
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23191482
119cellular response to interferon-beta (GO:0035458)3.21595816
120regulation of interleukin-2 biosynthetic process (GO:0045076)3.21538837
121lymphocyte chemotaxis (GO:0048247)3.18678796
122cellular response to zinc ion (GO:0071294)3.18529478
123NIK/NF-kappaB signaling (GO:0038061)3.18442974
124positive regulation of protein kinase C signaling (GO:0090037)3.18398994
125positive regulation of interferon-beta production (GO:0032728)3.18237710
126dendritic cell differentiation (GO:0097028)3.18184196
127positive regulation of isotype switching (GO:0045830)3.17973466
128regulation of type 2 immune response (GO:0002828)3.17253545
129* positive regulation of natural killer cell activation (GO:0032816)3.16302435
130regulation of mononuclear cell migration (GO:0071675)3.16091880
131* positive regulation of T cell differentiation (GO:0045582)3.15708194
132positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.15537566
133* regulation of activated T cell proliferation (GO:0046006)3.13810157
134regulation of monocyte chemotaxis (GO:0090025)3.13045382
135regulation of chronic inflammatory response (GO:0002676)3.12249985
136positive regulation of glycoprotein biosynthetic process (GO:0010560)3.11160601
137response to muramyl dipeptide (GO:0032495)3.08770079
138dendritic cell chemotaxis (GO:0002407)3.08752509
139* regulation of interferon-gamma biosynthetic process (GO:0045072)3.07889531
140regulation of podosome assembly (GO:0071801)3.07457041
141positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06962467
142positive regulation of humoral immune response (GO:0002922)3.06813175
143positive regulation of keratinocyte differentiation (GO:0045618)3.05823297
144cellular response to exogenous dsRNA (GO:0071360)3.05367514
145* response to protozoan (GO:0001562)3.04744141
146hydrogen peroxide biosynthetic process (GO:0050665)3.04494667
147positive regulation of T cell migration (GO:2000406)3.03692618
148positive regulation of interleukin-1 beta secretion (GO:0050718)3.03383066
149regulation of T cell chemotaxis (GO:0010819)3.03319635
150regulation of interferon-beta biosynthetic process (GO:0045357)3.01782762
151negative regulation of monooxygenase activity (GO:0032769)2.97615944
152vitamin catabolic process (GO:0009111)2.97107715
153fat-soluble vitamin catabolic process (GO:0042363)2.97107715
154* regulation of defense response to virus by host (GO:0050691)2.96079365
155regulation of cytokine secretion involved in immune response (GO:0002739)2.96025876
156* positive regulation of lymphocyte differentiation (GO:0045621)2.95843364
157positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94069729
158regulation of interleukin-1 secretion (GO:0050704)2.92270133
159* positive regulation of transcription factor import into nucleus (GO:0042993)2.87590226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.59128147
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.33098926
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.48322346
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.94166664
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87949177
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.25248111
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.07564081
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.93047520
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17320365
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16004198
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10727338
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06703277
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.95324662
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.87621794
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80927378
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.56172569
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49746728
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40496041
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.35910732
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17200143
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11037955
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05598302
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.96316293
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.89873507
25VDR_24787735_ChIP-Seq_THP-1_Human1.74183242
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.70269596
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.70269596
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.70269596
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70252943
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60655378
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45968987
32GATA1_22025678_ChIP-Seq_K562_Human1.45896920
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44062871
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43215547
35MYB_26560356_Chip-Seq_TH2_Human1.42428912
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.39489845
37* RUNX_20019798_ChIP-Seq_JUKART_Human1.37327057
38SPI1_23547873_ChIP-Seq_NB4_Human1.37080528
39GATA3_26560356_Chip-Seq_TH2_Human1.32292463
40* PU_27001747_Chip-Seq_BMDM_Mouse1.31108503
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31079378
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29271404
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27821812
44MAF_26560356_Chip-Seq_TH1_Human1.25215090
45EGR1_19032775_ChIP-ChIP_M12_Human1.25186678
46CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23198528
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22587462
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22199121
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.18913689
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17891297
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12740042
52ZNF274_21170338_ChIP-Seq_K562_Hela1.11698107
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10189625
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09532891
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08749110
56GATA3_27048872_Chip-Seq_THYMUS_Human1.08288850
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05541695
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04004813
59MYB_26560356_Chip-Seq_TH1_Human1.03005588
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02780621
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02674199
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02674199
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01773239
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00914902
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98103869
66* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97818682
67SOX2_20726797_ChIP-Seq_SW620_Human0.97589935
68VDR_24763502_ChIP-Seq_THP-1_Human0.97210002
69NFE2_27457419_Chip-Seq_LIVER_Mouse0.96309670
70STAT3_18555785_Chip-Seq_ESCs_Mouse0.95603021
71GATA2_21666600_ChIP-Seq_HMVEC_Human0.94197316
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.93608599
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93016024
74SPI1_23127762_ChIP-Seq_K562_Human0.91485939
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91454362
76ESR1_21235772_ChIP-Seq_MCF-7_Human0.90227744
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89723975
78CRX_20693478_ChIP-Seq_RETINA_Mouse0.88659277
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87889149
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87485114
81NANOG_18555785_Chip-Seq_ESCs_Mouse0.87406223
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87008774
83SMRT_27268052_Chip-Seq_Bcells_Human0.86822327
84* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86378910
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83358615
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82889408
87P300_18555785_Chip-Seq_ESCs_Mouse0.82775758
88RUNX1_22412390_ChIP-Seq_EML_Mouse0.82187721
89* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81729199
90SOX2_18555785_Chip-Seq_ESCs_Mouse0.80740157
91CTCF_18555785_Chip-Seq_ESCs_Mouse0.79975341
92STAT1_20625510_ChIP-Seq_HELA_Human0.79968026
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78291710
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78171586
95VDR_22108803_ChIP-Seq_LS180_Human0.77666865
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77277907
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.77178849
98OCT4_18555785_Chip-Seq_ESCs_Mouse0.77155916
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77142938
100TP53_18474530_ChIP-ChIP_U2OS_Human0.75922475
101* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75384071
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74917911
103FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74535073
104P53_22387025_ChIP-Seq_ESCs_Mouse0.73933394
105RUNX1_27457419_Chip-Seq_LIVER_Mouse0.72968180
106* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.71947163
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71299795
108KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70422588
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69266561
110SCL_19346495_ChIP-Seq_HPC-7_Human0.66221417
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.65911902
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.65648396
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.65648396
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.65100718
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.63086950
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58342161
117* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.57879158
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.57633444
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.57044908
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.56621251
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.56348031
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.55980655
123CJUN_26792858_Chip-Seq_BT549_Human0.55106960
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54920592
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.54852533
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.51370844
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50664398
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.50133289
129MAF_26560356_Chip-Seq_TH2_Human0.49852474
130* TP63_23658742_ChIP-Seq_EP156T_Human0.49090939
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.48927980
132PU1_27457419_Chip-Seq_LIVER_Mouse0.47894103
133SALL4_22934838_ChIP-ChIP_CD34+_Human0.47670393
134GATA3_26560356_Chip-Seq_TH1_Human0.47208472
135SPI1_20517297_ChIP-Seq_HL60_Human0.46502226
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.45952928
137P300_19829295_ChIP-Seq_ESCs_Human0.44812431
138SMAD1_18555785_Chip-Seq_ESCs_Mouse0.44427835
139NMYC_18555785_Chip-Seq_ESCs_Mouse0.44399409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.62842488
2* MP0009785_altered_susceptibility_to5.22925614
3* MP0002148_abnormal_hypersensitivity_rea4.60125564
4MP0005671_abnormal_response_to4.59127793
5MP0000685_abnormal_immune_system3.74997195
6MP0005000_abnormal_immune_tolerance3.44576595
7MP0008004_abnormal_stomach_pH3.41714974
8MP0003436_decreased_susceptibility_to3.33581125
9MP0005387_immune_system_phenotype3.31404000
10MP0001790_abnormal_immune_system3.31404000
11* MP0005025_abnormal_response_to3.26147076
12MP0006082_CNS_inflammation3.14991539
13MP0003724_increased_susceptibility_to3.00588725
14* MP0002419_abnormal_innate_immunity2.79965773
15MP0004510_myositis2.78724672
16MP0001348_abnormal_lacrimal_gland2.68953152
17MP0001800_abnormal_humoral_immune2.60655873
18* MP0002723_abnormal_immune_serum2.60367895
19MP0009764_decreased_sensitivity_to2.54573444
20* MP0002452_abnormal_antigen_presenting2.54075729
21MP0003303_peritoneal_inflammation2.43611888
22MP0002006_tumorigenesis2.42137496
23* MP0001819_abnormal_immune_cell2.20251560
24MP0002163_abnormal_gland_morphology2.17475966
25MP0003195_calcinosis2.12432867
26* MP0002420_abnormal_adaptive_immunity2.09760094
27MP0005451_abnormal_body_composition2.07741969
28MP0003448_altered_tumor_morphology2.02891084
29MP0003806_abnormal_nucleotide_metabolis1.92124322
30MP0004947_skin_inflammation1.78595227
31* MP0001845_abnormal_inflammatory_respons1.77485927
32MP0001346_abnormal_lacrimal_gland1.76006006
33MP0001853_heart_inflammation1.70969107
34* MP0008469_abnormal_protein_level1.67242109
35MP0002166_altered_tumor_susceptibility1.66556934
36MP0001533_abnormal_skeleton_physiology1.66250368
37MP0002138_abnormal_hepatobiliary_system1.63535707
38MP0000569_abnormal_digit_pigmentation1.61117808
39* MP0000716_abnormal_immune_system1.59156643
40MP0005310_abnormal_salivary_gland1.58823197
41* MP0010155_abnormal_intestine_physiology1.58617120
42* MP0002398_abnormal_bone_marrow1.45237036
43MP0005397_hematopoietic_system_phenotyp1.39960552
44MP0001545_abnormal_hematopoietic_system1.39960552
45MP0003075_altered_response_to1.39390325
46MP0009333_abnormal_splenocyte_physiolog1.39205923
47MP0003183_abnormal_peptide_metabolism1.39164127
48MP0008057_abnormal_DNA_replication1.38838203
49MP0000858_altered_metastatic_potential1.36417863
50MP0002139_abnormal_hepatobiliary_system1.29619738
51MP0005464_abnormal_platelet_physiology1.24973007
52* MP0002405_respiratory_system_inflammati1.21849690
53MP0005379_endocrine/exocrine_gland_phen1.17477816
54* MP0002429_abnormal_blood_cell1.17350958
55MP0003300_gastrointestinal_ulcer1.16279971
56MP0003646_muscle_fatigue1.15776603
57MP0003186_abnormal_redox_activity1.13690228
58* MP0009763_increased_sensitivity_to1.13335770
59MP0005167_abnormal_blood-brain_barrier1.12971920
60MP0003091_abnormal_cell_migration1.08643487
61MP0002998_abnormal_bone_remodeling1.06807030
62MP0005166_decreased_susceptibility_to1.04414058
63MP0005076_abnormal_cell_differentiation1.03632433
64MP0005164_abnormal_response_to1.00715942
65MP0004782_abnormal_surfactant_physiolog0.96949301
66MP0005647_abnormal_sex_gland0.96066131
67MP0000343_altered_response_to0.95535654
68MP0000689_abnormal_spleen_morphology0.94832955
69MP0008874_decreased_physiological_sensi0.94127243
70MP0003690_abnormal_glial_cell0.94066471
71MP0002722_abnormal_immune_system0.92485837
72MP0001881_abnormal_mammary_gland0.91685772
73MP0009278_abnormal_bone_marrow0.90666566
74MP0005266_abnormal_metabolism0.85491321
75MP0005058_abnormal_lysosome_morphology0.85336898
76MP0001727_abnormal_embryo_implantation0.84778466
77MP0003453_abnormal_keratinocyte_physiol0.84212975
78MP0002735_abnormal_chemical_nociception0.81084104
79MP0002254_reproductive_system_inflammat0.78136006
80MP0005390_skeleton_phenotype0.77247611
81MP0005319_abnormal_enzyme/_coenzyme0.76935700
82MP0001663_abnormal_digestive_system0.76349927
83MP0002736_abnormal_nociception_after0.75576311
84MP0002877_abnormal_melanocyte_morpholog0.74778629
85MP0003566_abnormal_cell_adhesion0.74661682
86MP0000678_abnormal_parathyroid_gland0.74152933
87MP0000627_abnormal_mammary_gland0.73959919
88MP0004808_abnormal_hematopoietic_stem0.72638853
89MP0010307_abnormal_tumor_latency0.72198331
90MP0010386_abnormal_urinary_bladder0.72103755
91MP0005171_absent_coat_pigmentation0.70968967
92MP0002332_abnormal_exercise_endurance0.67195783
93MP0001501_abnormal_sleep_pattern0.66667870
94MP0000604_amyloidosis0.66088361
95MP0005623_abnormal_meninges_morphology0.64764454
96MP0002693_abnormal_pancreas_physiology0.64271806
97MP0004858_abnormal_nervous_system0.63146745
98MP0008875_abnormal_xenobiotic_pharmacok0.62251392
99MP0000249_abnormal_blood_vessel0.62021504
100MP0001919_abnormal_reproductive_system0.61947816
101MP0003763_abnormal_thymus_physiology0.61049653
102MP0002168_other_aberrant_phenotype0.59459327
103MP0005410_abnormal_fertilization0.58452519
104MP0002277_abnormal_respiratory_mucosa0.57898321
105* MP0009765_abnormal_xenobiotic_induced0.56482165
106MP0004484_altered_response_of0.56028768
107MP0005408_hypopigmentation0.54229579
108MP0000371_diluted_coat_color0.54147694
109MP0003656_abnormal_erythrocyte_physiolo0.53484806
110MP0005535_abnormal_body_temperature0.52392851
111MP0006054_spinal_hemorrhage0.51830716
112MP0000920_abnormal_myelination0.50861360
113MP0001764_abnormal_homeostasis0.50781706
114MP0002136_abnormal_kidney_physiology0.50582835
115MP0004742_abnormal_vestibular_system0.50436874
116MP0009840_abnormal_foam_cell0.49256723
117MP0008873_increased_physiological_sensi0.49157503
118MP0010234_abnormal_vibrissa_follicle0.44810788
119MP0003172_abnormal_lysosome_physiology0.43642605
120MP0003191_abnormal_cellular_cholesterol0.43455268
121MP0003941_abnormal_skin_development0.43309939
122MP0005584_abnormal_enzyme/coenzyme_acti0.43238560
123MP0002295_abnormal_pulmonary_circulatio0.43214442
124MP0004883_abnormal_blood_vessel0.42041704
125MP0000703_abnormal_thymus_morphology0.40290825
126MP0003045_fibrosis0.39830148
127MP0010352_gastrointestinal_tract_polyps0.38496281

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)8.51346630
2Eczematoid dermatitis (HP:0000976)6.96897152
3Recurrent bacterial skin infections (HP:0005406)6.64416780
4Recurrent abscess formation (HP:0002722)6.43964514
5Mediastinal lymphadenopathy (HP:0100721)6.27593663
6Recurrent gram-negative bacterial infections (HP:0005420)5.56481011
7Generalized aminoaciduria (HP:0002909)5.23020762
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.19252927
9Abnormality of glycolipid metabolism (HP:0010969)5.11807962
10Abnormality of liposaccharide metabolism (HP:0010968)5.11807962
11Abnormality of glycosphingolipid metabolism (HP:0004343)5.11807962
12Hypergammaglobulinemia (HP:0010702)4.86487837
13Thin bony cortex (HP:0002753)4.72875404
14Enlarged epiphyses (HP:0010580)4.63389504
15Abnormality of macrophages (HP:0004311)4.52301454
16Elevated erythrocyte sedimentation rate (HP:0003565)4.42520559
17Hematochezia (HP:0002573)4.30224934
18Basal ganglia calcification (HP:0002135)4.29098442
19Recurrent skin infections (HP:0001581)4.27613768
20Gingivitis (HP:0000230)4.17604086
21Stomatitis (HP:0010280)4.07773216
22Autoimmune thrombocytopenia (HP:0001973)4.06416633
23Recurrent fungal infections (HP:0002841)4.03494223
24Delayed epiphyseal ossification (HP:0002663)4.00812076
25Recurrent viral infections (HP:0004429)4.00071790
26Abnormality of the costochondral junction (HP:0000919)3.99016251
27Optic neuritis (HP:0100653)3.94621400
28Retrobulbar optic neuritis (HP:0100654)3.94621400
29Metaphyseal irregularity (HP:0003025)3.93105641
30* Vasculitis (HP:0002633)3.89259133
31* Gastrointestinal infarctions (HP:0005244)3.82185508
32Widely patent fontanelles and sutures (HP:0004492)3.76352455
33Symptomatic seizures (HP:0011145)3.75662551
34Thick nail (HP:0001805)3.75034612
35Periodontitis (HP:0000704)3.74349728
36IgA deficiency (HP:0002720)3.71999274
37Orchitis (HP:0100796)3.71035328
38Porencephaly (HP:0002132)3.65010991
39Systemic lupus erythematosus (HP:0002725)3.58801516
40Myositis (HP:0100614)3.52238694
41Chronic otitis media (HP:0000389)3.46301988
42Flat occiput (HP:0005469)3.45824843
43Interstitial pulmonary disease (HP:0006530)3.43829169
44Pustule (HP:0200039)3.41666174
45Tetraparesis (HP:0002273)3.31492913
46Arterial thrombosis (HP:0004420)3.21064044
47Dysostosis multiplex (HP:0000943)3.20655857
48Cellulitis (HP:0100658)3.16240765
49Chronic obstructive pulmonary disease (HP:0006510)3.07840488
50Obstructive lung disease (HP:0006536)3.07840488
51Pulmonary infiltrates (HP:0002113)3.07024127
52Protuberant abdomen (HP:0001538)3.06965515
53Chronic mucocutaneous candidiasis (HP:0002728)3.01930484
54Recurrent cutaneous fungal infections (HP:0011370)3.01930484
55Increased serum ferritin (HP:0003281)2.99516717
56Joint swelling (HP:0001386)2.98175234
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.93006046
58Lower limb hyperreflexia (HP:0002395)2.91683960
59Abnormality of T cell number (HP:0011839)2.90632284
60Abnormality of polysaccharide metabolism (HP:0011012)2.83826768
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83826768
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83826768
63Premature loss of primary teeth (HP:0006323)2.82152343
64Gingival bleeding (HP:0000225)2.81459114
65Abnormality of B cell number (HP:0010975)2.76337035
66B lymphocytopenia (HP:0010976)2.75753662
67IgG deficiency (HP:0004315)2.75335585
68Cerebral hemorrhage (HP:0001342)2.72149111
69Osteolytic defects of the hand bones (HP:0009699)2.71417220
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.71417220
71Peritonitis (HP:0002586)2.70721290
72Myocardial infarction (HP:0001658)2.69402937
73Urinary glycosaminoglycan excretion (HP:0003541)2.68906697
74Mucopolysacchariduria (HP:0008155)2.68906697
75Recurrent pneumonia (HP:0006532)2.66551876
76Meningitis (HP:0001287)2.65113791
77Autoimmune hemolytic anemia (HP:0001890)2.61973273
78Increased cerebral lipofuscin (HP:0011813)2.60081990
79Abnormality of iron homeostasis (HP:0011031)2.58908933
80Abnormality of the pericardium (HP:0001697)2.57428187
81Agammaglobulinemia (HP:0004432)2.57421818
82* Gangrene (HP:0100758)2.54065220
83Chronic sinusitis (HP:0011109)2.52667055
84Leukocytosis (HP:0001974)2.51194290
85Thrombocytosis (HP:0001894)2.50542853
86Abnormality of transition element cation homeostasis (HP:0011030)2.49593094
87Urticaria (HP:0001025)2.49277127
88Nasal polyposis (HP:0100582)2.48245483
89Recurrent lower respiratory tract infections (HP:0002783)2.47167334
90Loss of speech (HP:0002371)2.41429634
91Recurrent bronchitis (HP:0002837)2.41228072
92Cleft eyelid (HP:0000625)2.40572477
93T lymphocytopenia (HP:0005403)2.40334581
94Disinhibition (HP:0000734)2.39607821
95Osteomyelitis (HP:0002754)2.38868242
96Stomach cancer (HP:0012126)2.37164118
97Neutropenia (HP:0001875)2.35025423
98Esophageal varix (HP:0002040)2.32212278
99Abnormality of the pleura (HP:0002103)2.30653274
100Albinism (HP:0001022)2.29948339
101Abnormality of the nasal mucosa (HP:0000433)2.25511085
102Increased neuronal autofluorescent lipopigment (HP:0002074)2.24894981
103Keratoconjunctivitis sicca (HP:0001097)2.24383593
104Hyperphosphatemia (HP:0002905)2.21694900
105Encephalitis (HP:0002383)2.21685108
106Axonal loss (HP:0003447)2.20340184
107Keratitis (HP:0000491)2.16872413
108Rickets (HP:0002748)2.16380120
109Eosinophilia (HP:0001880)2.12621911
110Hyperparathyroidism (HP:0000843)2.11887376
111Purpura (HP:0000979)2.07351437
112Plagiocephaly (HP:0001357)2.07130517
113* Arthralgia (HP:0002829)2.05339609
114Petechiae (HP:0000967)2.04760660
115Abnormal delayed hypersensitivity skin test (HP:0002963)2.04747759
116Sepsis (HP:0100806)2.03961444
117Poor head control (HP:0002421)2.03331639
118Abnormality of T cells (HP:0002843)2.03200969
119Keratoconjunctivitis (HP:0001096)2.02413155
120Mutism (HP:0002300)2.02283074
121* Hemoptysis (HP:0002105)2.01520117
122Femoral bowing (HP:0002980)2.01240084
123Parakeratosis (HP:0001036)2.00989430
124Tinnitus (HP:0000360)2.00715316
125Combined immunodeficiency (HP:0005387)1.98281463
126Apathy (HP:0000741)1.98204622
127Abnormality of the basal ganglia (HP:0002134)1.97732650
128Spastic tetraparesis (HP:0001285)1.97240566
129Polyneuropathy (HP:0001271)1.96372641
130Spontaneous hematomas (HP:0007420)1.93945382
131Hypophosphatemia (HP:0002148)1.92863764
132Colitis (HP:0002583)1.90793487
133Diminished motivation (HP:0000745)1.90635205
134Increased IgE level (HP:0003212)1.90047224
135Abnormality of eosinophils (HP:0001879)1.88798754
136Nephritis (HP:0000123)1.88122688
137Progressive visual loss (HP:0000529)1.88096175
138Spontaneous abortion (HP:0005268)1.86467360
139* Cerebral ischemia (HP:0002637)1.84450521
140* Skin ulcer (HP:0200042)1.84319523
141Polycythemia (HP:0001901)1.83507026
142Abnormality of T cell physiology (HP:0011840)1.81752256
143Prolonged neonatal jaundice (HP:0006579)1.81540026
144Chronic diarrhea (HP:0002028)1.81037898
145Abnormal trabecular bone morphology (HP:0100671)1.80551691
146Vacuolated lymphocytes (HP:0001922)1.80449974
147Prostate neoplasm (HP:0100787)1.78924099
148Vertigo (HP:0002321)1.78883651
149Thrombophlebitis (HP:0004418)1.77188666
150Progressive neurologic deterioration (HP:0002344)1.75268929
151Thyroiditis (HP:0100646)1.74370402
152Nuclear cataract (HP:0100018)1.74130767
153Alveolar cell carcinoma (HP:0006519)1.73574403
154Nausea (HP:0002018)1.71080189
155Episodic fever (HP:0001954)1.70663055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.97364790
2PBK4.59886601
3TBK13.98534503
4JAK33.69905719
5TYK23.60382157
6RIPK43.52598374
7MAP3K133.39271255
8IKBKB3.26131295
9PIM23.09937570
10IRAK42.84550439
11DDR22.83126718
12IKBKE2.71219592
13JAK12.52979922
14CHUK2.31586099
15ARAF2.31279338
16ACVR1B1.96211960
17NEK91.94193213
18MST41.91874399
19BLK1.89148991
20TAOK21.82596264
21FRK1.80271577
22BMPR21.73710566
23PRPF4B1.73220815
24EPHA31.65806875
25IRAK31.58960531
26FGFR41.46743269
27SYK1.37284718
28STK41.32754142
29EPHB11.31766523
30CLK11.27983023
31MAP3K91.24133276
32TYRO31.21060744
33JAK21.20919871
34EIF2AK21.19927908
35ERBB31.19843545
36IRAK11.08751474
37MAP4K11.05131659
38TRPM71.03919079
39CDC42BPA1.03126744
40HCK1.01271504
41ABL21.00924615
42MAP4K20.95930850
43TXK0.94958637
44MAP3K30.93423402
45KIT0.91141526
46FGFR30.90565899
47CSK0.90121005
48PRKCQ0.87130598
49LCK0.86440941
50PIM10.81462799
51ZAP700.81146687
52MKNK10.80770838
53TESK10.79708452
54BCKDK0.79702701
55ADRBK20.75920268
56LYN0.74216864
57BTK0.72355998
58DAPK30.71784518
59MAPKAPK50.71439545
60MOS0.70672616
61BCR0.69799300
62PKN10.69459711
63GRK70.68403938
64ZAK0.68161832
65WNK30.67992925
66FES0.67363005
67TAOK30.66368466
68PRKCD0.65918650
69CSF1R0.65398280
70SIK30.63614388
71LRRK20.62880760
72STK30.61695476
73MAP3K110.60342429
74EIF2AK30.59896780
75BMX0.58663701
76STK390.58358201
77YES10.57587822
78KSR20.57185160
79MARK30.55972962
80ABL10.55908538
81RPS6KA40.53910433
82WNK40.53867590
83MAP2K60.53435666
84MAP3K50.53069939
85PINK10.52526661
86MST1R0.50317123
87MATK0.49653230
88PLK20.47435882
89EGFR0.46324954
90NTRK10.45619729
91IRAK20.44241238
92MAP3K40.44205490
93MAP3K120.43160892
94PTK2B0.42770450
95WNK10.42452154
96NUAK10.42251060
97RIPK10.42014694
98PRKCE0.41898343
99NLK0.39340798
100HIPK20.38812536
101DAPK20.37105094
102ALK0.37044470
103INSRR0.36773740
104RPS6KA50.35684018
105TLK10.34795311
106EPHB20.32020765
107ERN10.29874405
108MAPKAPK20.29325927
109RAF10.29205564
110DYRK30.28544883
111MAPK40.28493902
112RET0.28333220
113FGR0.26727620
114IGF1R0.26682865
115DYRK1B0.25650427
116SIK20.25460648
117PDK10.23826209
118BRAF0.23775560
119PRKAA20.23397157
120RPS6KA10.23236989
121SRC0.23022557
122GSK3A0.22586093
123NME20.22162966
124FLT30.21745402
125PRKACG0.21703640
126MAP3K10.19643103
127PAK60.19339758
128DYRK20.18963324
129ERBB40.18734001
130STK380.17270306
131MAPK30.17267195
132TEC0.16001880
133MAP2K70.15795000
134STK240.15309031
135KSR10.14503696
136CDK150.14345953
137CDK180.14050239
138INSR0.13353789

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.64561434
2* Allograft rejection_Homo sapiens_hsa053304.26081926
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.34257240
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28365573
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.20131856
6* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.97965559
7Autoimmune thyroid disease_Homo sapiens_hsa053202.80655623
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.71599424
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.65423411
10* Type I diabetes mellitus_Homo sapiens_hsa049402.53293913
11* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.44521835
12Asthma_Homo sapiens_hsa053102.40746663
13* Leishmaniasis_Homo sapiens_hsa051402.38402341
14Rheumatoid arthritis_Homo sapiens_hsa053232.38238390
15* Measles_Homo sapiens_hsa051622.29031514
16* Pertussis_Homo sapiens_hsa051332.26034977
17Malaria_Homo sapiens_hsa051442.23088518
18TNF signaling pathway_Homo sapiens_hsa046682.05684826
19* Influenza A_Homo sapiens_hsa051642.02650507
20* Legionellosis_Homo sapiens_hsa051342.01312402
21Viral myocarditis_Homo sapiens_hsa054161.96734856
22* African trypanosomiasis_Homo sapiens_hsa051431.93889280
23* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84800300
24Staphylococcus aureus infection_Homo sapiens_hsa051501.70502447
25Osteoclast differentiation_Homo sapiens_hsa043801.68079846
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66438951
27* Herpes simplex infection_Homo sapiens_hsa051681.62557278
28* Tuberculosis_Homo sapiens_hsa051521.53396673
29Chemokine signaling pathway_Homo sapiens_hsa040621.52982386
30* Toxoplasmosis_Homo sapiens_hsa051451.49306366
31Prion diseases_Homo sapiens_hsa050201.46852539
32Primary immunodeficiency_Homo sapiens_hsa053401.42057984
33* Jak-STAT signaling pathway_Homo sapiens_hsa046301.33487538
34Salmonella infection_Homo sapiens_hsa051321.31148172
35* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26358317
36Steroid biosynthesis_Homo sapiens_hsa001001.17744336
37Apoptosis_Homo sapiens_hsa042101.16775789
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.15974678
39B cell receptor signaling pathway_Homo sapiens_hsa046621.06193014
40Shigellosis_Homo sapiens_hsa051310.96573983
41Hepatitis B_Homo sapiens_hsa051610.95139584
42Hepatitis C_Homo sapiens_hsa051600.94764330
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94658726
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93286683
45Phagosome_Homo sapiens_hsa041450.88970386
46Antigen processing and presentation_Homo sapiens_hsa046120.82905564
47Sulfur metabolism_Homo sapiens_hsa009200.81416745
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81304684
49Prolactin signaling pathway_Homo sapiens_hsa049170.80577402
50Proteasome_Homo sapiens_hsa030500.77617520
51Phenylalanine metabolism_Homo sapiens_hsa003600.76907686
52Hematopoietic cell lineage_Homo sapiens_hsa046400.76653900
53Other glycan degradation_Homo sapiens_hsa005110.75719750
54Dorso-ventral axis formation_Homo sapiens_hsa043200.71349477
55* Amoebiasis_Homo sapiens_hsa051460.71270746
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62487115
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57992852
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.57819699
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57608689
60T cell receptor signaling pathway_Homo sapiens_hsa046600.53492559
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.52567220
62Ether lipid metabolism_Homo sapiens_hsa005650.50941308
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50734196
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50530528
65Acute myeloid leukemia_Homo sapiens_hsa052210.49961295
66Epstein-Barr virus infection_Homo sapiens_hsa051690.48246993
67Caffeine metabolism_Homo sapiens_hsa002320.44609254
68Arachidonic acid metabolism_Homo sapiens_hsa005900.42323733
69Chronic myeloid leukemia_Homo sapiens_hsa052200.41023151
70Tryptophan metabolism_Homo sapiens_hsa003800.36373635
71Lysosome_Homo sapiens_hsa041420.36270354
72HIF-1 signaling pathway_Homo sapiens_hsa040660.33974107
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33847690
74Small cell lung cancer_Homo sapiens_hsa052220.33267304
75Viral carcinogenesis_Homo sapiens_hsa052030.33057072
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32864497
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.29550103
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29492588
79Type II diabetes mellitus_Homo sapiens_hsa049300.29445845
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27394421
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26340203
82Ovarian steroidogenesis_Homo sapiens_hsa049130.26142140
83Bladder cancer_Homo sapiens_hsa052190.25925050
84Complement and coagulation cascades_Homo sapiens_hsa046100.25742848
85Platelet activation_Homo sapiens_hsa046110.25740791
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24369517
87HTLV-I infection_Homo sapiens_hsa051660.24221727
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23605327
89Collecting duct acid secretion_Homo sapiens_hsa049660.22249258
90Sphingolipid metabolism_Homo sapiens_hsa006000.22128150
91Pancreatic cancer_Homo sapiens_hsa052120.20973541
92Insulin resistance_Homo sapiens_hsa049310.18057262
93Linoleic acid metabolism_Homo sapiens_hsa005910.15629387
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14510761
95Fatty acid biosynthesis_Homo sapiens_hsa000610.13057689
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13002733
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12307530
98Arginine biosynthesis_Homo sapiens_hsa002200.12014194
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11468540
100Systemic lupus erythematosus_Homo sapiens_hsa053220.11350446
101FoxO signaling pathway_Homo sapiens_hsa040680.09994642
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07835348
103MAPK signaling pathway_Homo sapiens_hsa040100.07493365
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07166017
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.06552533
106Phototransduction_Homo sapiens_hsa047440.06080333
107p53 signaling pathway_Homo sapiens_hsa041150.05627948
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04278171
109PPAR signaling pathway_Homo sapiens_hsa033200.03868991
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03725826
111Pentose phosphate pathway_Homo sapiens_hsa000300.03680797
112Tyrosine metabolism_Homo sapiens_hsa003500.03532074
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03099976
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.02855002
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02795144
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.02626625
117VEGF signaling pathway_Homo sapiens_hsa043700.02305724
118Mineral absorption_Homo sapiens_hsa04978-0.0296429
119Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0131975
120One carbon pool by folate_Homo sapiens_hsa00670-0.0102421
121ErbB signaling pathway_Homo sapiens_hsa04012-0.0064896
122Ras signaling pathway_Homo sapiens_hsa04014-0.0033124

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »