IL12RB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to interleukin-15 (GO:0070672)7.08507369
2positive regulation of gamma-delta T cell activation (GO:0046645)6.70434606
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.57314156
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.57314156
5negative T cell selection (GO:0043383)6.34368943
6cellular response to interleukin-15 (GO:0071350)6.26072391
7interferon-gamma production (GO:0032609)6.11828602
8negative thymic T cell selection (GO:0045060)6.07331379
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.85106015
10regulation of isotype switching to IgG isotypes (GO:0048302)5.82168887
11regulation of gamma-delta T cell differentiation (GO:0045586)5.71998021
12antigen processing and presentation of endogenous antigen (GO:0019883)5.54781451
13tolerance induction (GO:0002507)5.52009178
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15408640
15thymic T cell selection (GO:0045061)5.11577135
16regulation of gamma-delta T cell activation (GO:0046643)5.10658112
17positive thymic T cell selection (GO:0045059)5.09115917
18activated T cell proliferation (GO:0050798)4.97200578
19regulation of interleukin-2 biosynthetic process (GO:0045076)4.88072575
20tyrosine phosphorylation of STAT protein (GO:0007260)4.87235035
21T cell selection (GO:0045058)4.84144197
22positive T cell selection (GO:0043368)4.78452833
23regulation of natural killer cell mediated immunity (GO:0002715)4.73918734
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.73918734
25T cell migration (GO:0072678)4.62925065
26positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.62783950
27positive regulation of natural killer cell mediated immunity (GO:0002717)4.62783950
28T cell costimulation (GO:0031295)4.43263087
29regulation of interleukin-12 biosynthetic process (GO:0045075)4.40813126
30negative regulation of cell killing (GO:0031342)4.39036830
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39036830
32lymphocyte costimulation (GO:0031294)4.37590954
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.36166833
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.33969400
35positive regulation of isotype switching (GO:0045830)4.33747399
36T cell receptor signaling pathway (GO:0050852)4.33156786
37leukocyte aggregation (GO:0070486)4.30221224
38positive regulation of interleukin-2 production (GO:0032743)4.13995431
39positive regulation of natural killer cell differentiation (GO:0032825)3.96670871
40DNA deamination (GO:0045006)3.95580677
41JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.91090047
42regulation of alpha-beta T cell proliferation (GO:0046640)3.86255328
43positive regulation of B cell mediated immunity (GO:0002714)3.83108724
44positive regulation of immunoglobulin mediated immune response (GO:0002891)3.83108724
45regulation of regulatory T cell differentiation (GO:0045589)3.73581724
46positive regulation of humoral immune response (GO:0002922)3.69764099
47positive regulation of interleukin-17 production (GO:0032740)3.69571988
48antigen receptor-mediated signaling pathway (GO:0050851)3.68773172
49negative regulation of thymocyte apoptotic process (GO:0070244)3.65037202
50T cell homeostasis (GO:0043029)3.64377301
51positive regulation of DNA recombination (GO:0045911)3.62092945
52positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.61589862
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.60912457
54positive regulation of immunoglobulin production (GO:0002639)3.59789905
55cytidine deamination (GO:0009972)3.59007898
56cytidine metabolic process (GO:0046087)3.59007898
57cytidine catabolic process (GO:0006216)3.59007898
58* regulation of T cell mediated cytotoxicity (GO:0001914)3.56390889
59positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55279232
60regulation of isotype switching (GO:0045191)3.54738879
61* positive regulation of T cell mediated cytotoxicity (GO:0001916)3.52564014
62natural killer cell activation (GO:0030101)3.49179621
63* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.46102962
64regulation of interleukin-2 production (GO:0032663)3.44641218
65regulation of T cell tolerance induction (GO:0002664)3.42099319
66CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.41724493
67* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.41525650
68regulation of response to interferon-gamma (GO:0060330)3.36523414
69regulation of B cell receptor signaling pathway (GO:0050855)3.35358904
70regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.33664957
71* positive regulation of cell killing (GO:0031343)3.33049982
72regulation of immunoglobulin mediated immune response (GO:0002889)3.32762931
73pyrimidine ribonucleoside catabolic process (GO:0046133)3.31399119
74regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.30951136
75* regulation of cell killing (GO:0031341)3.29074662
76alpha-beta T cell activation (GO:0046631)3.26888854
77regulation of T cell receptor signaling pathway (GO:0050856)3.25790867
78regulation of B cell mediated immunity (GO:0002712)3.25644242
79alpha-beta T cell differentiation (GO:0046632)3.25520461
80regulation of immunoglobulin production (GO:0002637)3.24551491
81* positive regulation of lymphocyte mediated immunity (GO:0002708)3.22661430
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21149147
83response to protozoan (GO:0001562)3.20413711
84T cell proliferation (GO:0042098)3.20068202
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.19861942
86T cell differentiation involved in immune response (GO:0002292)3.19426981
87alpha-beta T cell differentiation involved in immune response (GO:0002293)3.19426981
88alpha-beta T cell activation involved in immune response (GO:0002287)3.19426981
89negative regulation of interleukin-12 production (GO:0032695)3.18155337
90regulation of B cell differentiation (GO:0045577)3.17745291
91mast cell activation (GO:0045576)3.16843582
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15270828
93Peyers patch development (GO:0048541)3.14937442
94mucosal-associated lymphoid tissue development (GO:0048537)3.14937442
95regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.14932613
96NIK/NF-kappaB signaling (GO:0038061)3.13828697
97positive regulation of macrophage differentiation (GO:0045651)3.10771618
98T cell differentiation (GO:0030217)3.09595928
99cellular extravasation (GO:0045123)3.09487146
100positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.08990231
101regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.08990231
102immunoglobulin mediated immune response (GO:0016064)3.08413654
103negative regulation of leukocyte mediated immunity (GO:0002704)3.06002174
104regulation of natural killer cell differentiation (GO:0032823)3.05502202
105defense response to protozoan (GO:0042832)3.05460786
106positive regulation by symbiont of host defense response (GO:0052509)3.03975367
107modulation by symbiont of host defense response (GO:0052031)3.03975367
108modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03975367
109modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03975367
110positive regulation by organism of defense response of other organism involved in symbiotic interact3.03975367
111modulation by symbiont of host immune response (GO:0052553)3.03975367
112regulation of type I interferon-mediated signaling pathway (GO:0060338)3.03781648
113* regulation of lymphocyte mediated immunity (GO:0002706)3.03719156
114response to type I interferon (GO:0034340)3.03580434
115B cell receptor signaling pathway (GO:0050853)3.03015422
116positive regulation of T cell cytokine production (GO:0002726)3.02116768
117type I interferon signaling pathway (GO:0060337)2.99737141
118cellular response to type I interferon (GO:0071357)2.99737141
119regulation of cytokine production involved in inflammatory response (GO:1900015)2.99653252
120neutrophil activation (GO:0042119)2.99331249
121lymphocyte homeostasis (GO:0002260)2.98489085
122fucose catabolic process (GO:0019317)2.98387675
123L-fucose metabolic process (GO:0042354)2.98387675
124L-fucose catabolic process (GO:0042355)2.98387675
125negative regulation of T cell mediated immunity (GO:0002710)2.98356447
126cellular response to interleukin-4 (GO:0071353)2.98296888
127myeloid dendritic cell activation (GO:0001773)2.97486498
128myeloid dendritic cell differentiation (GO:0043011)2.97060631
129* positive regulation of defense response to virus by host (GO:0002230)2.96936003
130positive regulation of B cell differentiation (GO:0045579)2.95771068
131mast cell activation involved in immune response (GO:0002279)2.95714047
132mast cell degranulation (GO:0043303)2.95714047
133positive regulation of granulocyte differentiation (GO:0030854)2.95108661
134negative regulation of interleukin-1 beta production (GO:0032691)2.93233116
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91292867
136neutrophil activation involved in immune response (GO:0002283)2.90791013
137detection of bacterium (GO:0016045)2.90112400
138negative regulation of interleukin-1 production (GO:0032692)2.89316339
139detection of other organism (GO:0098543)2.85774889
140positive regulation of antigen processing and presentation (GO:0002579)2.84453599
141leukocyte degranulation (GO:0043299)2.83078800
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81989835
143regulation of antigen processing and presentation (GO:0002577)2.80323188
144negative regulation of innate immune response (GO:0045824)2.78993657
145macrophage activation involved in immune response (GO:0002281)2.77213567
146negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76271587
147interferon-gamma-mediated signaling pathway (GO:0060333)2.76197236
148regulation of tolerance induction (GO:0002643)2.74703331
149behavioral response to nicotine (GO:0035095)2.73922264
150myeloid cell activation involved in immune response (GO:0002275)2.72936219
151regulation of mast cell activation (GO:0033003)2.70624948
152* regulation of T cell mediated immunity (GO:0002709)2.68328793
153dendritic cell chemotaxis (GO:0002407)2.67656825
154granulocyte activation (GO:0036230)2.66984925
155microglial cell activation (GO:0001774)2.66226030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.06326211
2E2F7_22180533_ChIP-Seq_HELA_Human5.98538098
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.32186225
4* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.75783638
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.56454959
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.51755328
7MYC_22102868_ChIP-Seq_BL_Human3.39201206
8* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37458356
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.34308189
10* MYB_26560356_Chip-Seq_TH2_Human3.09297834
11RUNX_20019798_ChIP-Seq_JUKART_Human3.03867224
12MAF_26560356_Chip-Seq_TH1_Human2.92116704
13* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90978173
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.81982425
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.81242676
16VDR_21846776_ChIP-Seq_THP-1_Human2.66247769
17ZNF274_21170338_ChIP-Seq_K562_Hela2.65213210
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61802779
19* MYB_26560356_Chip-Seq_TH1_Human2.55418226
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49489631
21UTX_26944678_Chip-Seq_JUKART_Human2.42217032
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.34341947
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.24647002
24MAF_26560356_Chip-Seq_TH2_Human2.21071574
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05853041
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98155852
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94288728
28TCF7_22412390_ChIP-Seq_EML_Mouse1.93823599
29VDR_24763502_ChIP-Seq_THP-1_Human1.91834566
30* RUNX1_22412390_ChIP-Seq_EML_Mouse1.90014698
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88922071
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88291742
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.87072804
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83561499
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82313812
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80647493
37* GATA3_27048872_Chip-Seq_THYMUS_Human1.76171476
38SCL_19346495_ChIP-Seq_HPC-7_Human1.75546391
39* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75055183
40SPI1_23547873_ChIP-Seq_NB4_Human1.72485281
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66008928
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.65601345
43KDM2B_26808549_Chip-Seq_DND41_Human1.64682592
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57595701
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57163429
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53935362
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53388181
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53335137
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.53223128
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51228610
51VDR_22108803_ChIP-Seq_LS180_Human1.50104098
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49775305
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48886415
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.45979625
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44857658
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36588649
57* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36145725
58VDR_24787735_ChIP-Seq_THP-1_Human1.34977300
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33994068
60* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29477830
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27750837
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27745807
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25526063
64VDR_23849224_ChIP-Seq_CD4+_Human1.22465134
65RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21684886
66* TP53_22573176_ChIP-Seq_HFKS_Human1.20781836
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.20638371
68SPI1_23127762_ChIP-Seq_K562_Human1.20388873
69ER_23166858_ChIP-Seq_MCF-7_Human1.19927714
70SMRT_27268052_Chip-Seq_Bcells_Human1.19585356
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19350193
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18298469
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18081878
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.18004927
75CIITA_25753668_ChIP-Seq_RAJI_Human1.17597619
76GBX2_23144817_ChIP-Seq_PC3_Human1.17562358
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.17232864
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16701727
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14968874
80* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14208777
81* BCL6_27268052_Chip-Seq_Bcells_Human1.12729209
82GATA3_26560356_Chip-Seq_TH2_Human1.12142039
83FOXP3_21729870_ChIP-Seq_TREG_Human1.11075299
84* NANOG_20526341_ChIP-Seq_ESCs_Human1.10340743
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09742203
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09237070
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08630267
88PU_27001747_Chip-Seq_BMDM_Mouse1.08287163
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07652757
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06841501
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06679192
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05903589
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.04578400
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04571725
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03212458
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02787888
97MYC_18555785_ChIP-Seq_MESCs_Mouse1.02668958
98BCAT_22108803_ChIP-Seq_LS180_Human1.02587873
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.02200903
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02200903
101EZH2_22144423_ChIP-Seq_EOC_Human1.01957305
102XRN2_22483619_ChIP-Seq_HELA_Human1.01311179
103GATA3_26560356_Chip-Seq_TH1_Human1.01303601
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00757644
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00254175
106* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99514580
107GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98870203
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98427993
109P300_27268052_Chip-Seq_Bcells_Human0.98349519
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98312639
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98211851
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.97884210
113TAF2_19829295_ChIP-Seq_ESCs_Human0.96941444
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96087994
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95461685
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95224205
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94926588
118* ERA_21632823_ChIP-Seq_H3396_Human0.94649489
119IRF1_19129219_ChIP-ChIP_H3396_Human0.94243763
120GATA1_22025678_ChIP-Seq_K562_Human0.93910614
121IGF1R_20145208_ChIP-Seq_DFB_Human0.90051413
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89601174
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89122140
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88902708
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87307845
126MYC_19829295_ChIP-Seq_ESCs_Human0.87038962
127BCOR_27268052_Chip-Seq_Bcells_Human0.87022347
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86408461
129OCT4_20526341_ChIP-Seq_ESCs_Human0.86373315
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85750861
131NCOR1_26117541_ChIP-Seq_K562_Human0.84738202
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84082498
133SOX2_19829295_ChIP-Seq_ESCs_Human0.84071294
134NANOG_19829295_ChIP-Seq_ESCs_Human0.84071294
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83516043
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.82517186
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82259686
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82216057
139* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82059475
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81435056
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80631368
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79473069
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78892941
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76968229
145KDM5A_27292631_Chip-Seq_BREAST_Human0.76927947
146* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76842689
147LXR_22292898_ChIP-Seq_THP-1_Human0.76673666
148ELK1_19687146_ChIP-ChIP_HELA_Human0.76280585
149E2F1_21310950_ChIP-Seq_MCF-7_Human0.74565165
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74224585
151FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73818887
152CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73479462
153SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73007407
154GABP_17652178_ChIP-ChIP_JURKAT_Human0.71988361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.85007179
2MP0003763_abnormal_thymus_physiology4.47520121
3MP0000685_abnormal_immune_system3.56889150
4MP0001790_abnormal_immune_system3.43135192
5MP0005387_immune_system_phenotype3.43135192
6MP0001835_abnormal_antigen_presentation3.41887462
7MP0001800_abnormal_humoral_immune3.27623902
8MP0009333_abnormal_splenocyte_physiolog3.17175686
9MP0005000_abnormal_immune_tolerance2.94148827
10MP0009785_altered_susceptibility_to2.91761389
11MP0001873_stomach_inflammation2.79510481
12* MP0002723_abnormal_immune_serum2.77502321
13MP0006082_CNS_inflammation2.76728484
14MP0003436_decreased_susceptibility_to2.72360214
15MP0002396_abnormal_hematopoietic_system2.70369673
16MP0002398_abnormal_bone_marrow2.68129707
17* MP0002420_abnormal_adaptive_immunity2.65478234
18MP0003866_abnormal_defecation2.63460220
19* MP0001819_abnormal_immune_cell2.60503790
20MP0003300_gastrointestinal_ulcer2.57834503
21MP0002166_altered_tumor_susceptibility2.55521850
22MP0002452_abnormal_antigen_presenting2.55210287
23MP0002405_respiratory_system_inflammati2.48852190
24MP0005025_abnormal_response_to2.48630913
25MP0010155_abnormal_intestine_physiology2.48449516
26MP0000703_abnormal_thymus_morphology2.47490821
27* MP0000716_abnormal_immune_system2.32089733
28MP0002006_tumorigenesis2.23685253
29MP0002722_abnormal_immune_system2.22512203
30MP0002933_joint_inflammation2.20329684
31MP0000689_abnormal_spleen_morphology2.14537425
32MP0001986_abnormal_taste_sensitivity2.13672146
33MP0004510_myositis1.93409192
34* MP0002429_abnormal_blood_cell1.92768267
35MP0003724_increased_susceptibility_to1.89274776
36MP0004947_skin_inflammation1.86196308
37MP0002148_abnormal_hypersensitivity_rea1.82786416
38MP0002277_abnormal_respiratory_mucosa1.79055086
39MP0002419_abnormal_innate_immunity1.74200713
40MP0001845_abnormal_inflammatory_respons1.70626744
41MP0003303_peritoneal_inflammation1.69703508
42MP0000569_abnormal_digit_pigmentation1.65765665
43MP0003448_altered_tumor_morphology1.60403598
44MP0005310_abnormal_salivary_gland1.59645887
45MP0001853_heart_inflammation1.53804039
46MP0004808_abnormal_hematopoietic_stem1.52685969
47MP0004381_abnormal_hair_follicle1.52360317
48MP0005464_abnormal_platelet_physiology1.51507356
49MP0002138_abnormal_hepatobiliary_system1.43845778
50MP0000465_gastrointestinal_hemorrhage1.39111209
51MP0008057_abnormal_DNA_replication1.32506656
52MP0003195_calcinosis1.26162797
53MP0000490_abnormal_crypts_of1.24780171
54MP0001851_eye_inflammation1.24686150
55MP0003646_muscle_fatigue1.23327057
56MP0001501_abnormal_sleep_pattern1.19391724
57MP0001968_abnormal_touch/_nociception1.16783155
58MP0001533_abnormal_skeleton_physiology1.15750084
59MP0000858_altered_metastatic_potential1.15056748
60* MP0008469_abnormal_protein_level1.14870063
61MP0010307_abnormal_tumor_latency1.13963030
62MP0008877_abnormal_DNA_methylation1.11963663
63MP0003183_abnormal_peptide_metabolism1.11856972
64MP0002019_abnormal_tumor_incidence1.10088159
65MP0002876_abnormal_thyroid_physiology1.10072344
66MP0010352_gastrointestinal_tract_polyps1.08986544
67MP0001545_abnormal_hematopoietic_system1.06819705
68MP0005397_hematopoietic_system_phenotyp1.06819705
69MP0008872_abnormal_physiological_respon1.05054164
70MP0002254_reproductive_system_inflammat1.01519130
71MP0000372_irregular_coat_pigmentation1.01250667
72MP0010094_abnormal_chromosome_stability0.99750482
73MP0005551_abnormal_eye_electrophysiolog0.98501243
74MP0005645_abnormal_hypothalamus_physiol0.98276451
75MP0003787_abnormal_imprinting0.97972660
76MP0002102_abnormal_ear_morphology0.96845630
77MP0004142_abnormal_muscle_tone0.93842934
78MP0002693_abnormal_pancreas_physiology0.93224190
79MP0001881_abnormal_mammary_gland0.93083821
80MP0003077_abnormal_cell_cycle0.92461097
81MP0000015_abnormal_ear_pigmentation0.89671260
82MP0003172_abnormal_lysosome_physiology0.88029920
83MP0004043_abnormal_pH_regulation0.87358933
84MP0002928_abnormal_bile_duct0.84381339
85MP0005075_abnormal_melanosome_morpholog0.83822931
86MP0001348_abnormal_lacrimal_gland0.82473337
87MP0005167_abnormal_blood-brain_barrier0.81661586
88MP0008875_abnormal_xenobiotic_pharmacok0.81509819
89MP0000920_abnormal_myelination0.80770409
90MP0003011_delayed_dark_adaptation0.79958126
91MP0009278_abnormal_bone_marrow0.79855350
92MP0003693_abnormal_embryo_hatching0.78063307
93MP0002998_abnormal_bone_remodeling0.76944766
94MP0009765_abnormal_xenobiotic_induced0.76583974
95MP0009763_increased_sensitivity_to0.76379021
96MP0001919_abnormal_reproductive_system0.75577956
97MP0004130_abnormal_muscle_cell0.74079199
98MP0005076_abnormal_cell_differentiation0.73965688
99MP0005451_abnormal_body_composition0.73300072
100MP0004742_abnormal_vestibular_system0.72753435
101MP0005377_hearing/vestibular/ear_phenot0.72642663
102MP0003878_abnormal_ear_physiology0.72642663
103MP0005023_abnormal_wound_healing0.71153440
104MP0005084_abnormal_gallbladder_morpholo0.71024827
105MP0003111_abnormal_nucleus_morphology0.69618705
106MP0000477_abnormal_intestine_morphology0.69436311
107MP0000604_amyloidosis0.69331002
108MP0004957_abnormal_blastocyst_morpholog0.68281534
109MP0003806_abnormal_nucleotide_metabolis0.66193761
110MP0002132_abnormal_respiratory_system0.65782492
111MP0001663_abnormal_digestive_system0.64775899
112MP0002653_abnormal_ependyma_morphology0.64648228
113MP0004883_abnormal_blood_vessel0.64588232
114MP0003252_abnormal_bile_duct0.63677894
115MP0000427_abnormal_hair_cycle0.63373215
116MP0003045_fibrosis0.61058575
117MP0001765_abnormal_ion_homeostasis0.60252911
118MP0002095_abnormal_skin_pigmentation0.59943912
119MP0009745_abnormal_behavioral_response0.59710935
120MP0002736_abnormal_nociception_after0.59351701
121MP0000609_abnormal_liver_physiology0.59271822
122MP0008873_increased_physiological_sensi0.59235060
123MP0000470_abnormal_stomach_morphology0.58069675
124MP0003091_abnormal_cell_migration0.57926046
125MP0005166_decreased_susceptibility_to0.57379548
126MP0005253_abnormal_eye_physiology0.57300720
127MP0000313_abnormal_cell_death0.56965594
128MP0009764_decreased_sensitivity_to0.56844026
129MP0000230_abnormal_systemic_arterial0.56335128
130MP0002163_abnormal_gland_morphology0.55960140
131MP0000350_abnormal_cell_proliferation0.55557407
132MP0000627_abnormal_mammary_gland0.53693286
133MP0003453_abnormal_keratinocyte_physiol0.52763066
134MP0008961_abnormal_basal_metabolism0.51582000
135MP0008007_abnormal_cellular_replicative0.51128217
136MP0001730_embryonic_growth_arrest0.50146568
137MP0001727_abnormal_embryo_implantation0.48660942
138MP0001216_abnormal_epidermal_layer0.45930298
139MP0003795_abnormal_bone_structure0.44008250
140MP0002009_preneoplasia0.42419682
141MP0008770_decreased_survivor_rate0.39638599
142MP0001191_abnormal_skin_condition0.39618117
143MP0000598_abnormal_liver_morphology0.39383315
144MP0005174_abnormal_tail_pigmentation0.37438162
145MP0002083_premature_death0.37121999
146MP0000733_abnormal_muscle_development0.35959696

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.83229175
2Abnormality of T cell number (HP:0011839)6.48180887
3Abnormality of T cells (HP:0002843)5.19759169
4Chronic otitis media (HP:0000389)5.16819263
5Elevated erythrocyte sedimentation rate (HP:0003565)5.15098638
6Myositis (HP:0100614)5.04876202
7Panhypogammaglobulinemia (HP:0003139)4.90427218
8Nasal polyposis (HP:0100582)4.88421404
9IgM deficiency (HP:0002850)4.88255825
10Recurrent bronchitis (HP:0002837)4.87862516
11Recurrent fungal infections (HP:0002841)4.79477343
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.65795083
13Recurrent viral infections (HP:0004429)4.57186611
14Chronic mucocutaneous candidiasis (HP:0002728)4.46351726
15Recurrent cutaneous fungal infections (HP:0011370)4.46351726
16Chronic diarrhea (HP:0002028)4.40375963
17Severe combined immunodeficiency (HP:0004430)4.30037622
18Optic neuritis (HP:0100653)4.24633840
19Retrobulbar optic neuritis (HP:0100654)4.24633840
20Stomatitis (HP:0010280)4.11349661
21Abnormality of the nasal mucosa (HP:0000433)4.00376027
22Abnormality of T cell physiology (HP:0011840)3.93260720
23Combined immunodeficiency (HP:0005387)3.91777297
24Orchitis (HP:0100796)3.78751328
25Abnormality of B cell number (HP:0010975)3.72065495
26B lymphocytopenia (HP:0010976)3.72065495
27Eczematoid dermatitis (HP:0000976)3.57986387
28IgG deficiency (HP:0004315)3.54015456
29IgA deficiency (HP:0002720)3.52616862
30Inflammation of the large intestine (HP:0002037)3.52111790
31Gastrointestinal inflammation (HP:0004386)3.43577163
32Joint swelling (HP:0001386)3.42534029
33Congenital stationary night blindness (HP:0007642)3.39455522
34Vasculitis (HP:0002633)3.35648807
35Meningitis (HP:0001287)3.26487563
36Recurrent bacterial skin infections (HP:0005406)3.24909516
37Encephalitis (HP:0002383)3.21937271
38Pustule (HP:0200039)3.18347018
39Hemoptysis (HP:0002105)3.13711501
40Pulmonary infiltrates (HP:0002113)3.12596329
41Stomach cancer (HP:0012126)3.12269104
42Abnormality of eosinophils (HP:0001879)3.09326782
43Increased density of long bones (HP:0006392)3.06394053
44Lymphopenia (HP:0001888)3.01567155
45Abnormality of the fingertips (HP:0001211)2.96363280
46Lymphoma (HP:0002665)2.96248884
47Eosinophilia (HP:0001880)2.91494796
48Keratoconjunctivitis sicca (HP:0001097)2.90081196
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.89550373
50Thrombocytosis (HP:0001894)2.88061556
51Leukocytosis (HP:0001974)2.87944222
52Recurrent skin infections (HP:0001581)2.86845600
53Increased IgE level (HP:0003212)2.82256924
54Autoimmune hemolytic anemia (HP:0001890)2.76618342
55Spontaneous hematomas (HP:0007420)2.74593012
56Keratoconjunctivitis (HP:0001096)2.73805848
57Arterial thrombosis (HP:0004420)2.73697409
58Granulocytopenia (HP:0001913)2.72811542
59Gastrointestinal infarctions (HP:0005244)2.67393833
60Gastrointestinal stroma tumor (HP:0100723)2.65088440
61Gingival bleeding (HP:0000225)2.63600236
62Pancreatic cysts (HP:0001737)2.63367018
63Attenuation of retinal blood vessels (HP:0007843)2.61897984
64Bronchitis (HP:0012387)2.61804236
65Hypochromic anemia (HP:0001931)2.60908653
66Pulmonary embolism (HP:0002204)2.60085559
67Thyroiditis (HP:0100646)2.58024912
68Cheilitis (HP:0100825)2.53688445
69Hypergammaglobulinemia (HP:0010702)2.46855908
70Recurrent sinusitis (HP:0011108)2.44879620
71Gangrene (HP:0100758)2.44235726
72Increased IgM level (HP:0003496)2.40321755
73Abnormal rod and cone electroretinograms (HP:0008323)2.39988208
74Molar tooth sign on MRI (HP:0002419)2.39369751
75Abnormality of midbrain morphology (HP:0002418)2.39369751
76Chronic obstructive pulmonary disease (HP:0006510)2.36139683
77Obstructive lung disease (HP:0006536)2.36139683
78Persistence of primary teeth (HP:0006335)2.34250654
79Chest pain (HP:0100749)2.32856474
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30521341
81Abnormal drinking behavior (HP:0030082)2.28776132
82Polydipsia (HP:0001959)2.28776132
83Abnormal platelet volume (HP:0011876)2.28527966
84Chronic sinusitis (HP:0011109)2.26945410
85Emphysema (HP:0002097)2.26480705
86Mediastinal lymphadenopathy (HP:0100721)2.25088675
87Hypochromic microcytic anemia (HP:0004840)2.22206239
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20826833
89Basal cell carcinoma (HP:0002671)2.18835916
90Abolished electroretinogram (ERG) (HP:0000550)2.18043334
91Autoimmune thrombocytopenia (HP:0001973)2.17445921
92Epistaxis (HP:0000421)2.17042501
93Abnormality of the renal cortex (HP:0011035)2.16000449
94Petechiae (HP:0000967)2.15398382
95Abnormality of macrophages (HP:0004311)2.13968461
96Arthralgia (HP:0002829)2.11100656
97Recurrent abscess formation (HP:0002722)2.09636489
98Interstitial pulmonary disease (HP:0006530)2.07569575
99Abnormality of the pleura (HP:0002103)2.05832789
100Pancreatic fibrosis (HP:0100732)2.05616874
101Recurrent gram-negative bacterial infections (HP:0005420)2.04882694
102Anorexia (HP:0002039)1.97075969
103Amaurosis fugax (HP:0100576)1.94874720
104Keratitis (HP:0000491)1.93493294
105Leukopenia (HP:0001882)1.91358687
106Episodic fever (HP:0001954)1.89930001
107True hermaphroditism (HP:0010459)1.87875586
108Papilloma (HP:0012740)1.85418448
109Verrucae (HP:0200043)1.85418448
110Progressive inability to walk (HP:0002505)1.85393224
111Skin ulcer (HP:0200042)1.84659878
112Chronic hepatic failure (HP:0100626)1.83447470
113Urticaria (HP:0001025)1.83060893
114Type II lissencephaly (HP:0007260)1.81678646
115Prolonged bleeding time (HP:0003010)1.81009644
116Agammaglobulinemia (HP:0004432)1.80885785
117Abnormality of the prostate (HP:0008775)1.79332288
118Increased mean platelet volume (HP:0011877)1.78490277
119Hepatosplenomegaly (HP:0001433)1.78016108
120Colitis (HP:0002583)1.77811789
121Abnormality of the endocardium (HP:0004306)1.77754805
122Cellulitis (HP:0100658)1.75656559
123Hemiplegia (HP:0002301)1.75102195
124Polyuria (HP:0000103)1.74742205
125Nephronophthisis (HP:0000090)1.72614634
126Bony spicule pigmentary retinopathy (HP:0007737)1.72184381
127Bronchiectasis (HP:0002110)1.72025690
128Hypoproteinemia (HP:0003075)1.71958091
1293-Methylglutaconic aciduria (HP:0003535)1.71696749
130Neutropenia (HP:0001875)1.71666053
131Hyperventilation (HP:0002883)1.71413153
132Decreased circulating renin level (HP:0003351)1.70958052
133Congenital sensorineural hearing impairment (HP:0008527)1.70902736
134Increased serum ferritin (HP:0003281)1.70853812
135Acute myeloid leukemia (HP:0004808)1.70545226
136Polyneuropathy (HP:0001271)1.70365722
137Clumsiness (HP:0002312)1.69443841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.75207207
2TXK5.62365696
3JAK33.91991591
4FRK3.22893743
5EEF2K3.07418086
6ITK2.93819118
7ZAP702.67926808
8FGFR42.62223326
9RIPK42.55972425
10TYK22.27404982
11STK102.25006089
12EPHB12.20784564
13JAK12.12743746
14TLK12.09227526
15MAP3K142.04194311
16IKBKE1.86701870
17LCK1.85927257
18TEC1.66904547
19GRK61.61354977
20BTK1.59313040
21WNK41.59002277
22ZAK1.56384659
23BLK1.53453687
24FGFR31.52435826
25ACVR1B1.50849878
26KIT1.45202421
27TESK21.42968772
28SYK1.42021758
29HCK1.39445063
30MAP4K21.36670318
31TBK11.34482268
32CLK11.31916708
33CAMKK21.29824497
34MST41.27571079
35PRKCQ1.21151033
36EPHA31.21112359
37NLK1.20848843
38CDC71.20555478
39CSK1.18468066
40TRIB31.15947083
41GRK11.15644370
42BMPR1B1.14974758
43TSSK61.14139445
44DAPK21.13019034
45NUAK11.11812363
46ERN11.09394014
47NME21.09294854
48SIK31.09207276
49PKN21.08546539
50CDK121.08050759
51MAP3K71.08025822
52LRRK21.05392231
53MAP2K61.03929778
54MAP3K101.02614871
55ALK1.02591155
56MAP2K31.01848767
57PINK11.00287630
58MAPK130.99507870
59IKBKB0.98002365
60FES0.97565942
61STK390.94812040
62PRKCH0.94680517
63SIK20.94195470
64JAK20.92605895
65ADRBK10.89519627
66CSF1R0.89125311
67TNK20.88744051
68CDK40.87483321
69PIM10.87307791
70PTK2B0.85260184
71OXSR10.84263921
72WNK30.80592708
73MATK0.80416248
74FGR0.75885980
75LYN0.74347315
76IRAK30.74323087
77GRK70.73585862
78KDR0.72439108
79PIM20.70313499
80MAP3K130.70296555
81TAOK30.69296060
82RPS6KA40.67294852
83CAMKK10.67141058
84MARK20.64494512
85CHUK0.63615671
86NEK20.63257367
87PASK0.61686043
88PRKD20.61506356
89MAP2K20.60241054
90STK110.56615347
91PIK3CG0.56399760
92MELK0.56091902
93MAP3K80.55908908
94MARK30.55383361
95INSRR0.53829829
96PDK10.53242610
97RPS6KA60.52745675
98PDGFRB0.52698294
99ROCK20.48971122
100IRAK40.48757923
101CSNK1A1L0.47707021
102MAPK70.47050805
103HIPK20.46449898
104PTK60.45505259
105MAPK120.43955631
106RPS6KA50.43362884
107ICK0.43164105
108RPS6KB20.42410798
109IRAK10.40689378
110FYN0.39988372
111MAPK110.37965107
112FGFR10.36643652
113MAPK150.36562694
114CDK60.36452771
115SIK10.36294387
116MAP3K30.36286032
117BCKDK0.35943947
118INSR0.34333247
119RAF10.34229248
120TTN0.33915859
121MAPKAPK20.33844357
122EGFR0.33647271
123PAK30.33376288
124PRKCZ0.31505960
125BRD40.30952708
126BMX0.30911031
127TYRO30.30359547
128STK40.30286136
129CHEK10.29981303
130CAMK10.29786643
131TRPM70.29766713
132CDK190.28765383
133CAMK40.28755596
134IGF1R0.28575163
135WNK10.27711561
136TAOK10.27542261
137PKN10.27395408
138MAP3K110.26118854
139DMPK0.25881218
140ADRBK20.25704761
141RPS6KC10.25419933
142RPS6KL10.25419933
143PRKCD0.25132946
144BMPR20.24143741
145DYRK20.23808265
146TGFBR10.23765062
147ABL10.23659360
148CSNK1G30.23076994
149PAK20.22892334

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.68014056
2* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.10898109
3Allograft rejection_Homo sapiens_hsa053304.08932815
4Graft-versus-host disease_Homo sapiens_hsa053323.70397572
5T cell receptor signaling pathway_Homo sapiens_hsa046603.44133861
6Autoimmune thyroid disease_Homo sapiens_hsa053202.97730944
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.77937932
8Measles_Homo sapiens_hsa051622.77324409
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.53913603
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.45808865
11Antigen processing and presentation_Homo sapiens_hsa046122.44561428
12Type I diabetes mellitus_Homo sapiens_hsa049402.41154551
13* Jak-STAT signaling pathway_Homo sapiens_hsa046302.19440390
14Hematopoietic cell lineage_Homo sapiens_hsa046401.97857467
15Asthma_Homo sapiens_hsa053101.84631085
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76672222
17Leishmaniasis_Homo sapiens_hsa051401.75126008
18B cell receptor signaling pathway_Homo sapiens_hsa046621.71320492
19Viral myocarditis_Homo sapiens_hsa054161.69883369
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68496257
21Osteoclast differentiation_Homo sapiens_hsa043801.67052116
22Linoleic acid metabolism_Homo sapiens_hsa005911.64549799
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44943137
24DNA replication_Homo sapiens_hsa030301.40775692
25Herpes simplex infection_Homo sapiens_hsa051681.37425424
26Toxoplasmosis_Homo sapiens_hsa051451.31490684
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27381462
28Acute myeloid leukemia_Homo sapiens_hsa052211.25686614
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25415694
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25140625
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23605104
32Chemokine signaling pathway_Homo sapiens_hsa040621.23083836
33Regulation of autophagy_Homo sapiens_hsa041401.21662147
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19305057
35Ribosome_Homo sapiens_hsa030101.18256099
36Phototransduction_Homo sapiens_hsa047441.16392081
37Hepatitis B_Homo sapiens_hsa051611.13669377
38HTLV-I infection_Homo sapiens_hsa051661.10782857
39Malaria_Homo sapiens_hsa051441.07799840
40Ether lipid metabolism_Homo sapiens_hsa005651.07228551
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05910653
42Viral carcinogenesis_Homo sapiens_hsa052031.04816747
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.02007145
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01162691
45Apoptosis_Homo sapiens_hsa042101.00931354
46Nitrogen metabolism_Homo sapiens_hsa009101.00423899
47Non-homologous end-joining_Homo sapiens_hsa034501.00188795
48Shigellosis_Homo sapiens_hsa051310.99907519
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99769168
50Epstein-Barr virus infection_Homo sapiens_hsa051690.99763154
51TNF signaling pathway_Homo sapiens_hsa046680.99080676
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97810200
53Influenza A_Homo sapiens_hsa051640.95684026
54Chronic myeloid leukemia_Homo sapiens_hsa052200.95241523
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90699126
56Mismatch repair_Homo sapiens_hsa034300.85802684
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84535803
58Spliceosome_Homo sapiens_hsa030400.83500660
59Pancreatic cancer_Homo sapiens_hsa052120.82550080
60Prolactin signaling pathway_Homo sapiens_hsa049170.81643996
61Arachidonic acid metabolism_Homo sapiens_hsa005900.80923478
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80103781
63Legionellosis_Homo sapiens_hsa051340.79082266
64Caffeine metabolism_Homo sapiens_hsa002320.75564997
65One carbon pool by folate_Homo sapiens_hsa006700.75175046
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71453907
67Renal cell carcinoma_Homo sapiens_hsa052110.71228691
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70999857
69Base excision repair_Homo sapiens_hsa034100.70449385
70Staphylococcus aureus infection_Homo sapiens_hsa051500.69425039
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69250037
72ABC transporters_Homo sapiens_hsa020100.68407990
73Salmonella infection_Homo sapiens_hsa051320.68287455
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67943027
75Hepatitis C_Homo sapiens_hsa051600.67914412
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67147299
77VEGF signaling pathway_Homo sapiens_hsa043700.66872684
78Tuberculosis_Homo sapiens_hsa051520.66220254
79Morphine addiction_Homo sapiens_hsa050320.64012882
80Dorso-ventral axis formation_Homo sapiens_hsa043200.61622801
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.61470488
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61140035
83Platelet activation_Homo sapiens_hsa046110.59903164
84Rheumatoid arthritis_Homo sapiens_hsa053230.58655358
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56951361
86Pertussis_Homo sapiens_hsa051330.56435525
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.56260231
88Endocytosis_Homo sapiens_hsa041440.55806933
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55617590
90Olfactory transduction_Homo sapiens_hsa047400.55549117
91RNA transport_Homo sapiens_hsa030130.54170033
92Cell cycle_Homo sapiens_hsa041100.54156837
93HIF-1 signaling pathway_Homo sapiens_hsa040660.53321931
94Phagosome_Homo sapiens_hsa041450.53074468
95Collecting duct acid secretion_Homo sapiens_hsa049660.50460896
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50119923
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49918865
98RNA degradation_Homo sapiens_hsa030180.49530868
99p53 signaling pathway_Homo sapiens_hsa041150.49251359
100Glycerolipid metabolism_Homo sapiens_hsa005610.49208065
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48333798
102Taste transduction_Homo sapiens_hsa047420.48027760
103Small cell lung cancer_Homo sapiens_hsa052220.47184584
104Homologous recombination_Homo sapiens_hsa034400.46579684
105Nucleotide excision repair_Homo sapiens_hsa034200.46482816
106mRNA surveillance pathway_Homo sapiens_hsa030150.44258209
107Colorectal cancer_Homo sapiens_hsa052100.43267115
108Selenocompound metabolism_Homo sapiens_hsa004500.43195812
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42558374
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42273841
111Notch signaling pathway_Homo sapiens_hsa043300.41717116
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.40727520
113MicroRNAs in cancer_Homo sapiens_hsa052060.40684392
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.39851058
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39122383
116Proteasome_Homo sapiens_hsa030500.38989215
117Tryptophan metabolism_Homo sapiens_hsa003800.37702827
118Non-small cell lung cancer_Homo sapiens_hsa052230.37518893
119Basal transcription factors_Homo sapiens_hsa030220.37475951
120Lysosome_Homo sapiens_hsa041420.37304971
121Ovarian steroidogenesis_Homo sapiens_hsa049130.36192467
122Butanoate metabolism_Homo sapiens_hsa006500.35679566
123Systemic lupus erythematosus_Homo sapiens_hsa053220.35357947
124Fanconi anemia pathway_Homo sapiens_hsa034600.35113632
125Pentose phosphate pathway_Homo sapiens_hsa000300.34003740
126RNA polymerase_Homo sapiens_hsa030200.32917626
127MAPK signaling pathway_Homo sapiens_hsa040100.30223438
128Peroxisome_Homo sapiens_hsa041460.29434930
129Prostate cancer_Homo sapiens_hsa052150.29157709
130Serotonergic synapse_Homo sapiens_hsa047260.29146027
131Nicotine addiction_Homo sapiens_hsa050330.28673522
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25952053
133Calcium signaling pathway_Homo sapiens_hsa040200.25312627
134African trypanosomiasis_Homo sapiens_hsa051430.24175515
135Sulfur relay system_Homo sapiens_hsa041220.22326668
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.22120894
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.21821658
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21782642
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.20843668
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16676781
141mTOR signaling pathway_Homo sapiens_hsa041500.14131146
142Pathways in cancer_Homo sapiens_hsa052000.12572626
143Inositol phosphate metabolism_Homo sapiens_hsa005620.11126246
144FoxO signaling pathway_Homo sapiens_hsa040680.08953093
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08868861

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