IL12RB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)7.57329610
2regulation of T cell chemotaxis (GO:0010819)6.49612265
3positive regulation of T cell chemotaxis (GO:0010820)6.49612265
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.72575722
5positive regulation of gamma-delta T cell activation (GO:0046645)5.44469202
6* interferon-gamma production (GO:0032609)5.43339467
7lymphocyte chemotaxis (GO:0048247)5.38384010
8negative regulation of interleukin-2 production (GO:0032703)5.23120481
9regulation of T cell cytokine production (GO:0002724)5.15386750
10negative T cell selection (GO:0043383)5.14368657
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.05206119
12negative thymic T cell selection (GO:0045060)5.00823307
13positive regulation of type 2 immune response (GO:0002830)5.00000654
14negative regulation of cytokine production involved in immune response (GO:0002719)4.95003569
15positive regulation of transforming growth factor beta production (GO:0071636)4.79608143
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.77075991
17regulation of T cell mediated cytotoxicity (GO:0001914)4.69787160
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63595959
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63595959
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.52199203
21T cell migration (GO:0072678)4.48968956
22regulation of lymphocyte chemotaxis (GO:1901623)4.45427485
23negative regulation of alpha-beta T cell activation (GO:0046636)4.33000968
24cellular response to interleukin-15 (GO:0071350)4.32639512
25positive regulation of granulocyte differentiation (GO:0030854)4.26372008
26antigen processing and presentation of endogenous antigen (GO:0019883)4.24283263
27negative regulation of adaptive immune response based on somatic recombination of immune receptors b4.24088935
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.19885561
29negative regulation of production of molecular mediator of immune response (GO:0002701)4.19882556
30negative regulation of cell killing (GO:0031342)4.19642685
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19642685
32response to interleukin-15 (GO:0070672)4.17521148
33regulation of interleukin-12 biosynthetic process (GO:0045075)4.17417484
34thymic T cell selection (GO:0045061)4.16991589
35regulation of activation of Janus kinase activity (GO:0010533)4.16836948
36protein K11-linked deubiquitination (GO:0035871)4.16794727
37cellular response to interleukin-4 (GO:0071353)4.15460078
38regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)4.12686497
39regulation of alpha-beta T cell proliferation (GO:0046640)4.08855382
40positive regulation of neutrophil migration (GO:1902624)4.04719801
41positive regulation of neutrophil chemotaxis (GO:0090023)4.04719801
42mucosal-associated lymphoid tissue development (GO:0048537)4.03377843
43Peyers patch development (GO:0048541)4.03377843
44positive thymic T cell selection (GO:0045059)4.01120527
45T cell selection (GO:0045058)3.95674445
46leukocyte aggregation (GO:0070486)3.94853116
47positive regulation of isotype switching (GO:0045830)3.92800108
48positive regulation of immunoglobulin production (GO:0002639)3.92129955
49negative regulation of adaptive immune response (GO:0002820)3.91625623
50regulation of hypersensitivity (GO:0002883)3.90380886
51positive regulation of interleukin-2 production (GO:0032743)3.85855951
52regulation of gamma-delta T cell differentiation (GO:0045586)3.84119330
53negative regulation of leukocyte mediated immunity (GO:0002704)3.81759976
54regulation of B cell receptor signaling pathway (GO:0050855)3.80780847
55natural killer cell activation (GO:0030101)3.80693637
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.76288550
57regulation of natural killer cell mediated immunity (GO:0002715)3.76288550
58positive regulation of T cell migration (GO:2000406)3.74257406
59positive T cell selection (GO:0043368)3.73138798
60regulation of gamma-delta T cell activation (GO:0046643)3.72603190
61tolerance induction (GO:0002507)3.72073111
62positive regulation of B cell differentiation (GO:0045579)3.71466376
63positive regulation of alpha-beta T cell activation (GO:0046635)3.69273005
64positive regulation of T cell mediated immunity (GO:0002711)3.69159064
65regulation of interleukin-2 production (GO:0032663)3.69013628
66myeloid dendritic cell activation (GO:0001773)3.68595972
67regulation of memory T cell differentiation (GO:0043380)3.66011959
68activated T cell proliferation (GO:0050798)3.65527741
69regulation of isotype switching to IgG isotypes (GO:0048302)3.64040575
70positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.63321705
71positive regulation of T cell cytokine production (GO:0002726)3.62251563
72myeloid dendritic cell differentiation (GO:0043011)3.62095057
73DNA deamination (GO:0045006)3.59697801
74positive regulation of B cell mediated immunity (GO:0002714)3.59549029
75positive regulation of immunoglobulin mediated immune response (GO:0002891)3.59549029
76positive regulation of granulocyte chemotaxis (GO:0071624)3.58557821
77regulation of interleukin-2 biosynthetic process (GO:0045076)3.55286546
78cellular response to type I interferon (GO:0071357)3.52984473
79type I interferon signaling pathway (GO:0060337)3.52984473
80response to type I interferon (GO:0034340)3.52427063
81positive regulation of DNA recombination (GO:0045911)3.50150719
82neutrophil activation involved in immune response (GO:0002283)3.48762603
83regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.47120261
84regulation of T cell tolerance induction (GO:0002664)3.46947709
85response to interleukin-4 (GO:0070670)3.46006595
86regulation of T cell receptor signaling pathway (GO:0050856)3.44941511
87tyrosine phosphorylation of STAT protein (GO:0007260)3.43990080
88positive regulation of lymphocyte migration (GO:2000403)3.43744320
89mast cell activation (GO:0045576)3.41363556
90cellular defense response (GO:0006968)3.41139941
91positive regulation of T-helper 1 type immune response (GO:0002827)3.40751607
92regulation of immunoglobulin production (GO:0002637)3.39765194
93regulation of alpha-beta T cell activation (GO:0046634)3.38114075
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.37584970
95T cell costimulation (GO:0031295)3.36204666
96positive regulation of natural killer cell differentiation (GO:0032825)3.36003203
97positive regulation of defense response to virus by host (GO:0002230)3.35388060
98positive regulation of interleukin-10 production (GO:0032733)3.34787405
99regulation of T cell migration (GO:2000404)3.34589706
100negative regulation of T cell mediated immunity (GO:0002710)3.33782109
101regulation of leukocyte mediated cytotoxicity (GO:0001910)3.33419266
102response to muramyl dipeptide (GO:0032495)3.31308135
103lymphocyte costimulation (GO:0031294)3.30590777
104mast cell degranulation (GO:0043303)3.30095241
105mast cell activation involved in immune response (GO:0002279)3.30095241
106regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.29159810
107regulation of cell killing (GO:0031341)3.27792867
108positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.27263640
109positive regulation of natural killer cell mediated immunity (GO:0002717)3.27263640
110regulation of T-helper 1 type immune response (GO:0002825)3.26870593
111positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.26853411
112alpha-beta T cell activation (GO:0046631)3.26016710
113positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.25826294
114regulation of regulatory T cell differentiation (GO:0045589)3.24257796
115positive regulation of humoral immune response (GO:0002922)3.23840830
116regulation of chronic inflammatory response (GO:0002676)3.23441006
117T-helper cell differentiation (GO:0042093)3.23345456
118CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.23345456
119* positive regulation of interferon-gamma production (GO:0032729)3.21028391
120positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20195216
121T cell receptor signaling pathway (GO:0050852)3.18604316
122angiogenesis involved in wound healing (GO:0060055)3.17153703
123T cell activation involved in immune response (GO:0002286)3.17095528
124regulation of neutrophil migration (GO:1902622)3.16876805
125regulation of neutrophil chemotaxis (GO:0090022)3.16876805
126cellular extravasation (GO:0045123)3.14884416
127regulation of B cell differentiation (GO:0045577)3.14879480
128NIK/NF-kappaB signaling (GO:0038061)3.14834976
129leukocyte cell-cell adhesion (GO:0007159)3.14387790
130regulation of T cell mediated immunity (GO:0002709)3.14213797
131alpha-beta T cell activation involved in immune response (GO:0002287)3.13369609
132T cell differentiation involved in immune response (GO:0002292)3.13369609
133alpha-beta T cell differentiation involved in immune response (GO:0002293)3.13369609
134interferon-gamma-mediated signaling pathway (GO:0060333)3.13272241
135regulation of B cell mediated immunity (GO:0002712)3.12172017
136regulation of T-helper 1 cell differentiation (GO:0045625)3.11520226
137regulation of immunoglobulin mediated immune response (GO:0002889)3.11418200
138positive regulation of interferon-alpha production (GO:0032727)3.09477896
139neutrophil activation (GO:0042119)3.09012270
140positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.08672566
141lymphocyte migration (GO:0072676)3.08347140
142positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.07845321
143positive regulation of lymphocyte mediated immunity (GO:0002708)3.07490109
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07257283
145alpha-beta T cell differentiation (GO:0046632)3.07125085
146positive regulation of macrophage differentiation (GO:0045651)3.07074649
147positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.06869624
148cellular response to interferon-beta (GO:0035458)3.06492394
149granulocyte activation (GO:0036230)3.05288856
150positive regulation of cell killing (GO:0031343)3.05219041
151cytidine metabolic process (GO:0046087)3.00444462
152cytidine catabolic process (GO:0006216)3.00444462
153cytidine deamination (GO:0009972)3.00444462
154natural killer cell differentiation (GO:0001779)2.95129919
155regulation of type 2 immune response (GO:0002828)2.93982837
156iron-sulfur cluster assembly (GO:0016226)2.91536158
157metallo-sulfur cluster assembly (GO:0031163)2.91536158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.82760748
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.64748988
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.71892601
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.57786894
5IRF8_21731497_ChIP-ChIP_J774_Mouse5.06357576
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.67271974
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.25728999
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.10435730
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.70849816
10E2F7_22180533_ChIP-Seq_HELA_Human3.70739962
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32730018
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.21000942
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02679018
14RUNX_20019798_ChIP-Seq_JUKART_Human2.94546359
15MYB_26560356_Chip-Seq_TH2_Human2.85284273
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.82165548
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78290628
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72778080
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.58232540
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48823951
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45233203
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41532080
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.34002910
24* MAF_26560356_Chip-Seq_TH1_Human2.30493178
25MYB_26560356_Chip-Seq_TH1_Human2.25424544
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12081157
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06369058
28SPI1_23547873_ChIP-Seq_NB4_Human2.00668785
29SCL_19346495_ChIP-Seq_HPC-7_Human1.98809129
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89033324
31VDR_23849224_ChIP-Seq_CD4+_Human1.87767590
32FOXP3_21729870_ChIP-Seq_TREG_Human1.82693550
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.81971824
34UTX_26944678_Chip-Seq_JUKART_Human1.70508408
35ZNF274_21170338_ChIP-Seq_K562_Hela1.70364603
36GATA3_27048872_Chip-Seq_THYMUS_Human1.68957780
37MYC_22102868_ChIP-Seq_BL_Human1.63502793
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62789423
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61113392
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58112929
41PU_27001747_Chip-Seq_BMDM_Mouse1.52770922
42VDR_24763502_ChIP-Seq_THP-1_Human1.52609735
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.51215006
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.50276515
45VDR_21846776_ChIP-Seq_THP-1_Human1.49838864
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49064206
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.47724194
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47531627
49CIITA_25753668_ChIP-Seq_RAJI_Human1.43170246
50GATA3_26560356_Chip-Seq_TH2_Human1.37897607
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36002232
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35711789
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33459579
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30645293
55MAF_26560356_Chip-Seq_TH2_Human1.30453447
56TCF7_22412390_ChIP-Seq_EML_Mouse1.30452743
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30005100
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.29634118
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29098165
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28778390
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28235608
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27977013
63VDR_24787735_ChIP-Seq_THP-1_Human1.27219908
64VDR_22108803_ChIP-Seq_LS180_Human1.26638416
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25795374
66SPI1_23127762_ChIP-Seq_K562_Human1.25530310
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24698845
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.19088851
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18744718
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17986074
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16227326
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15759688
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13471500
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12703793
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.11958564
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10302999
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07164947
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07130986
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06265621
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05819845
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04181943
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01731454
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01708839
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00069300
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99503981
86DCP1A_22483619_ChIP-Seq_HELA_Human0.97853742
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97118314
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96860123
89* GATA3_26560356_Chip-Seq_TH1_Human0.96707859
90KDM5A_27292631_Chip-Seq_BREAST_Human0.96655614
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93228823
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93046038
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92841468
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91899536
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91788745
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88389147
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87577206
98E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87532385
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86507292
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.85087940
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85074636
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84937470
103PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83082322
104EZH2_27294783_Chip-Seq_NPCs_Mouse0.82872515
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82812745
106P300_27268052_Chip-Seq_Bcells_Human0.82670945
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82288412
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81087070
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78730285
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78533075
111OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78230593
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77163964
113SPI1_20517297_ChIP-Seq_HL60_Human0.76663535
114KDM2B_26808549_Chip-Seq_DND41_Human0.76663494
115SMRT_27268052_Chip-Seq_Bcells_Human0.76659052
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76522142
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75200045
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74951116
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.74296600
120FOXM1_23109430_ChIP-Seq_U2OS_Human0.74254666
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73561178
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69747721
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.68023734
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.64826381
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64065369
126* GATA2_21666600_ChIP-Seq_HMVEC_Human0.61894803
127EGR1_19032775_ChIP-ChIP_M12_Human0.61416827
128ELK1_19687146_ChIP-ChIP_HELA_Human0.60578427
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.60543264
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.60471255
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.59297544
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.59297544
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.57833456
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57505147
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.56119471
136SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.54937119
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.54734467
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.53800420
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.52254406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.48258525
2MP0001835_abnormal_antigen_presentation4.40227708
3MP0009785_altered_susceptibility_to3.95098275
4MP0006082_CNS_inflammation3.75362264
5MP0003436_decreased_susceptibility_to3.36623879
6MP0002148_abnormal_hypersensitivity_rea3.35288503
7* MP0005000_abnormal_immune_tolerance3.26867425
8MP0003763_abnormal_thymus_physiology3.22737939
9MP0000685_abnormal_immune_system3.22499650
10MP0005387_immune_system_phenotype3.15952285
11MP0001790_abnormal_immune_system3.15952285
12MP0001800_abnormal_humoral_immune3.09941463
13* MP0005025_abnormal_response_to2.98364683
14* MP0002723_abnormal_immune_serum2.88230360
15* MP0002452_abnormal_antigen_presenting2.75310396
16* MP0001819_abnormal_immune_cell2.68477932
17* MP0002420_abnormal_adaptive_immunity2.67246018
18MP0004510_myositis2.58246651
19* MP0002419_abnormal_innate_immunity2.47032913
20MP0003724_increased_susceptibility_to2.37280115
21MP0002405_respiratory_system_inflammati2.32582254
22MP0009333_abnormal_splenocyte_physiolog2.28260382
23* MP0002398_abnormal_bone_marrow2.27407497
24MP0002166_altered_tumor_susceptibility2.25083437
25* MP0002006_tumorigenesis2.22351744
26MP0003045_fibrosis2.19416367
27* MP0000716_abnormal_immune_system2.11271644
28MP0010155_abnormal_intestine_physiology2.09260143
29MP0004947_skin_inflammation2.05752230
30MP0003646_muscle_fatigue2.01698911
31MP0001853_heart_inflammation1.89812389
32MP0003303_peritoneal_inflammation1.85418570
33* MP0001845_abnormal_inflammatory_respons1.84092296
34MP0005464_abnormal_platelet_physiology1.82182135
35MP0005451_abnormal_body_composition1.82123242
36MP0010094_abnormal_chromosome_stability1.81444431
37* MP0002722_abnormal_immune_system1.81405935
38MP0001986_abnormal_taste_sensitivity1.79997261
39* MP0003448_altered_tumor_morphology1.77438210
40MP0000858_altered_metastatic_potential1.76197420
41MP0001873_stomach_inflammation1.75086574
42MP0000689_abnormal_spleen_morphology1.73538978
43MP0000703_abnormal_thymus_morphology1.72635168
44* MP0002429_abnormal_blood_cell1.67422087
45* MP0005310_abnormal_salivary_gland1.63684879
46MP0001533_abnormal_skeleton_physiology1.58815950
47MP0002933_joint_inflammation1.53661770
48MP0001851_eye_inflammation1.47887883
49MP0008058_abnormal_DNA_repair1.45835626
50MP0002396_abnormal_hematopoietic_system1.44706620
51MP0003866_abnormal_defecation1.41635137
52MP0005174_abnormal_tail_pigmentation1.39899343
53MP0002163_abnormal_gland_morphology1.38815491
54MP0009764_decreased_sensitivity_to1.35161030
55MP0002009_preneoplasia1.34566535
56* MP0008469_abnormal_protein_level1.34422397
57MP0004381_abnormal_hair_follicle1.31584648
58MP0005397_hematopoietic_system_phenotyp1.30679376
59MP0001545_abnormal_hematopoietic_system1.30679376
60MP0008877_abnormal_DNA_methylation1.29780264
61MP0000569_abnormal_digit_pigmentation1.28007997
62MP0002998_abnormal_bone_remodeling1.25601661
63MP0000490_abnormal_crypts_of1.25046641
64MP0003806_abnormal_nucleotide_metabolis1.24091391
65MP0003300_gastrointestinal_ulcer1.21848653
66MP0009278_abnormal_bone_marrow1.20395908
67MP0008057_abnormal_DNA_replication1.17889692
68MP0003786_premature_aging1.17709097
69MP0002132_abnormal_respiratory_system1.16628495
70MP0003183_abnormal_peptide_metabolism1.12487220
71MP0004808_abnormal_hematopoietic_stem1.09044829
72MP0001661_extended_life_span1.06598623
73MP0008872_abnormal_physiological_respon1.02214972
74MP0001501_abnormal_sleep_pattern1.00991792
75MP0000013_abnormal_adipose_tissue0.96431984
76MP0000343_altered_response_to0.96294849
77MP0004043_abnormal_pH_regulation0.94359705
78MP0001348_abnormal_lacrimal_gland0.92567748
79MP0009763_increased_sensitivity_to0.88080871
80MP0001919_abnormal_reproductive_system0.87080237
81* MP0002019_abnormal_tumor_incidence0.86985551
82MP0003693_abnormal_embryo_hatching0.83123001
83MP0002138_abnormal_hepatobiliary_system0.82843421
84MP0002277_abnormal_respiratory_mucosa0.82574212
85MP0009697_abnormal_copulation0.81848754
86MP0003111_abnormal_nucleus_morphology0.78524315
87MP0008875_abnormal_xenobiotic_pharmacok0.77944891
88MP0003453_abnormal_keratinocyte_physiol0.76231792
89MP0006035_abnormal_mitochondrial_morpho0.75770008
90MP0005390_skeleton_phenotype0.75527915
91MP0004185_abnormal_adipocyte_glucose0.74953009
92MP0004142_abnormal_muscle_tone0.73772920
93MP0002254_reproductive_system_inflammat0.73478669
94MP0005166_decreased_susceptibility_to0.73245050
95MP0010307_abnormal_tumor_latency0.71469920
96MP0005075_abnormal_melanosome_morpholog0.70409886
97MP0006036_abnormal_mitochondrial_physio0.67001974
98MP0001346_abnormal_lacrimal_gland0.66360231
99MP0005645_abnormal_hypothalamus_physiol0.66227141
100MP0004130_abnormal_muscle_cell0.65871809
101MP0008873_increased_physiological_sensi0.65438432
102MP0010352_gastrointestinal_tract_polyps0.64478705
103MP0003172_abnormal_lysosome_physiology0.64166702
104MP0001216_abnormal_epidermal_layer0.63996976
105MP0005379_endocrine/exocrine_gland_phen0.63827288
106MP0000015_abnormal_ear_pigmentation0.63351465
107MP0000372_irregular_coat_pigmentation0.63010032
108MP0000465_gastrointestinal_hemorrhage0.63007437
109MP0009765_abnormal_xenobiotic_induced0.62295826
110MP0005076_abnormal_cell_differentiation0.61959858
111MP0004782_abnormal_surfactant_physiolog0.61181677
112MP0002877_abnormal_melanocyte_morpholog0.59257281
113MP0008007_abnormal_cellular_replicative0.59093435
114MP0001663_abnormal_digestive_system0.56698347
115MP0000313_abnormal_cell_death0.55166235
116MP0003795_abnormal_bone_structure0.55141815
117MP0001764_abnormal_homeostasis0.54764291
118MP0001270_distended_abdomen0.54722043
119MP0002970_abnormal_white_adipose0.53352107
120MP0000627_abnormal_mammary_gland0.53109769
121MP0003828_pulmonary_edema0.53043223
122MP0003091_abnormal_cell_migration0.52310493
123MP0005389_reproductive_system_phenotype0.51692157
124MP0002083_premature_death0.50863914
125MP0005410_abnormal_fertilization0.50654752
126MP0005647_abnormal_sex_gland0.49910816
127MP0000358_abnormal_cell_content/0.49713738
128MP0000383_abnormal_hair_follicle0.49675974
129MP0002095_abnormal_skin_pigmentation0.49575011
130MP0003566_abnormal_cell_adhesion0.48944588
131MP0002693_abnormal_pancreas_physiology0.47351865
132* MP0002136_abnormal_kidney_physiology0.46591037
133MP0000604_amyloidosis0.44693534
134MP0003136_yellow_coat_color0.44074906
135MP0000367_abnormal_coat/_hair0.42607271
136MP0000249_abnormal_blood_vessel0.42070197
137MP0003077_abnormal_cell_cycle0.41228462

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.99900995
2Eczematoid dermatitis (HP:0000976)5.51857067
3Recurrent abscess formation (HP:0002722)5.23391118
4Stomatitis (HP:0010280)5.23345072
5Abnormality of T cell number (HP:0011839)4.93940300
6* Myositis (HP:0100614)4.80508912
7Recurrent fungal infections (HP:0002841)4.75444886
8T lymphocytopenia (HP:0005403)4.62412364
9Recurrent bacterial skin infections (HP:0005406)4.61082748
10* Optic neuritis (HP:0100653)4.36218129
11* Retrobulbar optic neuritis (HP:0100654)4.36218129
12Mediastinal lymphadenopathy (HP:0100721)4.31373997
13Nasal polyposis (HP:0100582)4.28740752
14Chronic otitis media (HP:0000389)4.14492195
15* Orchitis (HP:0100796)4.13474990
16Autoimmune hemolytic anemia (HP:0001890)4.03014986
17Chronic mucocutaneous candidiasis (HP:0002728)4.00330953
18Recurrent cutaneous fungal infections (HP:0011370)4.00330953
19Recurrent viral infections (HP:0004429)3.97958687
20Increased IgM level (HP:0003496)3.92800775
21Agammaglobulinemia (HP:0004432)3.85686762
22Abnormality of T cells (HP:0002843)3.70909398
23* Vasculitis (HP:0002633)3.68419082
24Autoimmune thrombocytopenia (HP:0001973)3.68299092
25Abnormality of lateral ventricle (HP:0030047)3.67211496
26Recurrent gram-negative bacterial infections (HP:0005420)3.63690251
27Recurrent skin infections (HP:0001581)3.57489993
28Abnormality of macrophages (HP:0004311)3.55965622
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.49083752
30Obstructive lung disease (HP:0006536)3.42866150
31Chronic obstructive pulmonary disease (HP:0006510)3.42866150
32Severe combined immunodeficiency (HP:0004430)3.42264232
33Abnormality of the nasal mucosa (HP:0000433)3.40308703
34Recurrent bronchitis (HP:0002837)3.36899782
35* Meningitis (HP:0001287)3.27000391
36Abnormality of the labia minora (HP:0012880)3.24727035
37IgM deficiency (HP:0002850)3.23737054
38Combined immunodeficiency (HP:0005387)3.20468573
39Joint swelling (HP:0001386)3.20410438
40IgG deficiency (HP:0004315)3.16824996
41Congenital stationary night blindness (HP:0007642)3.12174068
42Hypoplastic ischia (HP:0003175)3.11624247
43Leukocytosis (HP:0001974)3.09204609
44Prominent nose (HP:0000448)3.07403500
45Eosinophilia (HP:0001880)3.05704879
46Gastrointestinal infarctions (HP:0005244)2.99897499
47Panhypogammaglobulinemia (HP:0003139)2.94902410
48Chronic diarrhea (HP:0002028)2.94314185
49Abnormality of eosinophils (HP:0001879)2.93736990
50Prostate neoplasm (HP:0100787)2.90855493
51Cheilitis (HP:0100825)2.88237505
52Gingivitis (HP:0000230)2.84179545
53* Encephalitis (HP:0002383)2.84109134
54Hypergammaglobulinemia (HP:0010702)2.83851435
55* Pulmonary infiltrates (HP:0002113)2.82647595
56Abnormality of T cell physiology (HP:0011840)2.81974720
57Abnormality of the fingertips (HP:0001211)2.78190600
58* Hemoptysis (HP:0002105)2.78011184
59Thyroiditis (HP:0100646)2.76001864
60Abnormality of the prostate (HP:0008775)2.73762901
61Dyschromatopsia (HP:0007641)2.72629080
62Slow saccadic eye movements (HP:0000514)2.70675772
63Poikiloderma (HP:0001029)2.70413192
64Cutaneous melanoma (HP:0012056)2.70140778
65Granulocytopenia (HP:0001913)2.69809783
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69662828
67Type I transferrin isoform profile (HP:0003642)2.67519030
68Petechiae (HP:0000967)2.66614830
69Pustule (HP:0200039)2.65015166
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.64291827
71Sparse scalp hair (HP:0002209)2.64148912
72Abnormality of B cell number (HP:0010975)2.62097642
73B lymphocytopenia (HP:0010976)2.62097642
74IgA deficiency (HP:0002720)2.59749829
75Lymphopenia (HP:0001888)2.57553247
76Basal ganglia calcification (HP:0002135)2.52950281
77Periodontitis (HP:0000704)2.49549938
783-Methylglutaconic aciduria (HP:0003535)2.48000865
79Hepatocellular necrosis (HP:0001404)2.47630020
80Abnormal protein glycosylation (HP:0012346)2.47380861
81Abnormal glycosylation (HP:0012345)2.47380861
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47380861
83Abnormal protein N-linked glycosylation (HP:0012347)2.47380861
84Inflammation of the large intestine (HP:0002037)2.45190855
85* Keratoconjunctivitis sicca (HP:0001097)2.45150201
86Fetal akinesia sequence (HP:0001989)2.45004873
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44292176
88Increased IgE level (HP:0003212)2.44033822
89Abnormality of the ischium (HP:0003174)2.42263845
90Attenuation of retinal blood vessels (HP:0007843)2.42027023
91Basal cell carcinoma (HP:0002671)2.40351237
92Gingival bleeding (HP:0000225)2.38009186
93Squamous cell carcinoma (HP:0002860)2.37852109
94* Arterial thrombosis (HP:0004420)2.36816889
95Colitis (HP:0002583)2.30299843
96Cerebral hypomyelination (HP:0006808)2.28498648
97Lymphoma (HP:0002665)2.27821418
98Cellulitis (HP:0100658)2.27159453
99Bilateral sensorineural hearing impairment (HP:0008619)2.26974604
100Thrombocytosis (HP:0001894)2.26406988
101* Keratoconjunctivitis (HP:0001096)2.25707623
102Villous atrophy (HP:0011473)2.24544919
103Abnormality of small intestinal villus morphology (HP:0011472)2.24544919
104Gastrointestinal inflammation (HP:0004386)2.24297748
105Central scotoma (HP:0000603)2.23382998
106Spontaneous hematomas (HP:0007420)2.22982163
107Horizontal nystagmus (HP:0000666)2.21458448
108Interstitial pulmonary disease (HP:0006530)2.20925812
109Acute myeloid leukemia (HP:0004808)2.17186642
110* Gangrene (HP:0100758)2.16974749
111Impaired smooth pursuit (HP:0007772)2.12858699
112Hypoproteinemia (HP:0003075)2.12795672
113Microvesicular hepatic steatosis (HP:0001414)2.12590341
114Generalized hypopigmentation of hair (HP:0011358)2.11840930
115Recurrent pneumonia (HP:0006532)2.10458970
116Fair hair (HP:0002286)2.07194955
117Chronic sinusitis (HP:0011109)2.05701944
118Abnormality of DNA repair (HP:0003254)2.05442288
119Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04133712
120Chest pain (HP:0100749)2.03280768
121* Arthralgia (HP:0002829)2.02875475
122Urticaria (HP:0001025)2.02546082
123Menstrual irregularities (HP:0000858)2.01106185
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98964219
125Recurrent sinusitis (HP:0011108)1.97856698
126Epistaxis (HP:0000421)1.96848467
127Hypochromic anemia (HP:0001931)1.96812177
128Muscle stiffness (HP:0003552)1.96635085
129Hepatic necrosis (HP:0002605)1.95927759
130Skin ulcer (HP:0200042)1.95590307
131Alveolar cell carcinoma (HP:0006519)1.95108275
132Amniotic constriction ring (HP:0009775)1.94779574
133Abnormality of placental membranes (HP:0011409)1.94779574
134Dysautonomia (HP:0002459)1.93808102
135Hypoplasia of the thymus (HP:0000778)1.93801717
136Prolonged bleeding time (HP:0003010)1.92103322
137Viral hepatitis (HP:0006562)1.90549851
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.89372155
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85269480
140Bronchitis (HP:0012387)1.84981208
141Lower limb hyperreflexia (HP:0002395)1.82663512
142* Abnormality of the endocardium (HP:0004306)1.82363584
143Neoplasm of the tracheobronchial system (HP:0100552)1.82171259
144Thick nail (HP:0001805)1.81755645
145* Keratitis (HP:0000491)1.80126338
146Leukopenia (HP:0001882)1.79040850
147Ileus (HP:0002595)1.78051028
148Abnormality of the periventricular white matter (HP:0002518)1.77581766
149Recurrent lower respiratory tract infections (HP:0002783)1.77420473
150Chronic hepatic failure (HP:0100626)1.75174445
151Hyperlipoproteinemia (HP:0010980)1.73514471
152Stomach cancer (HP:0012126)1.72273218
153Gaze-evoked nystagmus (HP:0000640)1.71207597
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69550741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.34210219
2MAP4K14.17848942
3MAP3K143.61745914
4JAK33.54011889
5TYK23.38537412
6FRK2.79645093
7IKBKE2.65526840
8ITK2.54056643
9TBK12.52169151
10JAK12.40673066
11KIT2.28165463
12IRAK42.21175400
13IKBKB2.16500091
14FGFR42.11458799
15MST42.08101567
16BLK1.99776788
17SRPK11.98037747
18PIK3CG1.96107307
19ZAP701.93475757
20IRAK31.92613711
21STK101.83418417
22TEC1.69356632
23FGFR31.67929388
24CHUK1.65242147
25BTK1.57729171
26SYK1.56146737
27LCK1.56006639
28CSK1.55357448
29EIF2AK31.51299305
30PIM21.50442534
31BMPR21.48166479
32HCK1.45110279
33PIM11.37003615
34VRK21.34524377
35SIK21.32417380
36MAP3K131.30408047
37CAMKK21.29734133
38NLK1.26682148
39SIK31.25111688
40EEF2K1.22032084
41RIPK41.20353669
42NEK91.17137099
43EPHA31.14361012
44KDR1.13740389
45MAP3K121.09951477
46GRK71.09506223
47FES1.08938773
48PRKCQ1.06737166
49PINK11.04710298
50JAK21.04346288
51EPHB11.04251072
52NME11.04206059
53NME21.03307248
54ADRBK21.01962193
55LYN0.99068150
56TAOK30.89200907
57MARK30.89187479
58TGFBR20.85687472
59RPS6KA40.84751982
60ZAK0.84470080
61GRK60.82419450
62DAPK10.81340599
63BCKDK0.80642458
64CDK120.79665589
65TRPM70.75445440
66PRPF4B0.75024867
67CDK40.74611552
68BRD40.74033998
69TNK20.73524139
70IRAK10.73369115
71NUAK10.72689444
72WNK30.71979239
73CSF1R0.70989863
74MAP3K70.68923417
75FGR0.68893328
76STK40.66478815
77MAPK70.65188553
78STK240.64630493
79NEK10.62637339
80ALK0.62504422
81CDK90.62145978
82RIPK10.61392819
83PBK0.60021872
84OBSCN0.58007343
85PRKCH0.56896067
86MAPK120.54419017
87CAMKK10.53818505
88CLK10.53465158
89CDK60.51206705
90RPS6KA50.48538552
91MAP3K100.48105343
92RAF10.46806257
93EIF2AK20.46472411
94MAPKAPK20.46049467
95NEK20.45048974
96MAPK110.44172151
97LRRK20.43561596
98SCYL20.42802499
99FLT30.41555580
100PDK10.41256088
101ABL10.40170326
102HIPK20.39702113
103YES10.38191958
104MATK0.37790977
105WNK40.34481300
106BMX0.34378587
107MELK0.33278164
108MAP2K30.32210086
109EGFR0.32204398
110PRKCD0.31844610
111RPS6KB20.31628410
112MAP3K10.31376815
113TESK20.30755448
114ERN10.29657571
115MAPK130.29000925
116MAP3K50.28358863
117ATR0.28187348
118DMPK0.28171725
119IGF1R0.28006414
120CDK190.27577147
121TSSK60.27096908
122MAPKAPK30.24925691
123FER0.24768400
124FYN0.23447539
125TLK10.23332754
126PIK3CA0.22166852
127MAP3K30.21872446
128MAP3K110.19833912
129RPS6KA60.18602371
130MAP2K60.17826263
131MAPK30.17496489
132STK30.17087451
133GSK3A0.15594349
134MAP3K80.14671720

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.23659351
2Allograft rejection_Homo sapiens_hsa053303.90454087
3* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.32764224
4Primary immunodeficiency_Homo sapiens_hsa053402.92483964
5Type I diabetes mellitus_Homo sapiens_hsa049402.81253495
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.73404295
7Measles_Homo sapiens_hsa051622.65952252
8Leishmaniasis_Homo sapiens_hsa051402.63527948
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.58802538
10Autoimmune thyroid disease_Homo sapiens_hsa053202.46892567
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.35746579
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27854633
13RNA polymerase_Homo sapiens_hsa030202.21103752
14T cell receptor signaling pathway_Homo sapiens_hsa046602.15913393
15One carbon pool by folate_Homo sapiens_hsa006702.14235936
16Antigen processing and presentation_Homo sapiens_hsa046122.12054812
17Osteoclast differentiation_Homo sapiens_hsa043802.06106960
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04771963
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89835202
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86879810
21* Jak-STAT signaling pathway_Homo sapiens_hsa046301.83135793
22Hematopoietic cell lineage_Homo sapiens_hsa046401.78832927
23Viral myocarditis_Homo sapiens_hsa054161.68528998
24TNF signaling pathway_Homo sapiens_hsa046681.66608254
25* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59011873
26Rheumatoid arthritis_Homo sapiens_hsa053231.57794995
27Legionellosis_Homo sapiens_hsa051341.56753715
28Malaria_Homo sapiens_hsa051441.53982081
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53680513
30Proteasome_Homo sapiens_hsa030501.53231977
31Influenza A_Homo sapiens_hsa051641.51820878
32Herpes simplex infection_Homo sapiens_hsa051681.51803365
33Toxoplasmosis_Homo sapiens_hsa051451.47416257
34Pertussis_Homo sapiens_hsa051331.42782571
35Tuberculosis_Homo sapiens_hsa051521.42132531
36B cell receptor signaling pathway_Homo sapiens_hsa046621.39048368
37Asthma_Homo sapiens_hsa053101.36081105
38Chemokine signaling pathway_Homo sapiens_hsa040621.31276496
39Staphylococcus aureus infection_Homo sapiens_hsa051501.31027334
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29385971
41Apoptosis_Homo sapiens_hsa042101.23986893
42Hepatitis B_Homo sapiens_hsa051611.19563058
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.16654374
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15514019
45Shigellosis_Homo sapiens_hsa051311.11317923
46Pyrimidine metabolism_Homo sapiens_hsa002401.08053232
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07190338
48Salmonella infection_Homo sapiens_hsa051321.03735750
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02349681
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.98640430
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98391375
52ABC transporters_Homo sapiens_hsa020100.93154220
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93036094
54Nucleotide excision repair_Homo sapiens_hsa034200.92043812
55African trypanosomiasis_Homo sapiens_hsa051430.90347412
56Linoleic acid metabolism_Homo sapiens_hsa005910.88815947
57Acute myeloid leukemia_Homo sapiens_hsa052210.87619991
58Purine metabolism_Homo sapiens_hsa002300.84906552
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83694308
60Hepatitis C_Homo sapiens_hsa051600.83059632
61Mismatch repair_Homo sapiens_hsa034300.82233107
62HTLV-I infection_Homo sapiens_hsa051660.79300946
63Epstein-Barr virus infection_Homo sapiens_hsa051690.79002147
64Prolactin signaling pathway_Homo sapiens_hsa049170.77923728
65Pancreatic cancer_Homo sapiens_hsa052120.77001171
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75776541
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75774453
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72832210
69RNA transport_Homo sapiens_hsa030130.72311309
70Chronic myeloid leukemia_Homo sapiens_hsa052200.71448498
71Spliceosome_Homo sapiens_hsa030400.69618976
72Platelet activation_Homo sapiens_hsa046110.65542909
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65526793
74Basal transcription factors_Homo sapiens_hsa030220.65141371
75N-Glycan biosynthesis_Homo sapiens_hsa005100.65136786
76Selenocompound metabolism_Homo sapiens_hsa004500.64762463
77Viral carcinogenesis_Homo sapiens_hsa052030.60108237
78Pentose phosphate pathway_Homo sapiens_hsa000300.59251494
79Phagosome_Homo sapiens_hsa041450.54992143
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54805674
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51405128
82p53 signaling pathway_Homo sapiens_hsa041150.50778155
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50738497
84Butanoate metabolism_Homo sapiens_hsa006500.49812374
85Olfactory transduction_Homo sapiens_hsa047400.49342881
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48977462
87Ether lipid metabolism_Homo sapiens_hsa005650.48177301
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.48097819
89Non-homologous end-joining_Homo sapiens_hsa034500.47117788
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44618228
91Systemic lupus erythematosus_Homo sapiens_hsa053220.43515855
92Homologous recombination_Homo sapiens_hsa034400.42581109
93Small cell lung cancer_Homo sapiens_hsa052220.41608177
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41528764
95VEGF signaling pathway_Homo sapiens_hsa043700.40843098
96Colorectal cancer_Homo sapiens_hsa052100.39569900
97Arachidonic acid metabolism_Homo sapiens_hsa005900.38224681
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.37591662
99Calcium signaling pathway_Homo sapiens_hsa040200.36702909
100DNA replication_Homo sapiens_hsa030300.35698851
101Biosynthesis of amino acids_Homo sapiens_hsa012300.34462483
102Phototransduction_Homo sapiens_hsa047440.34418725
103Lysosome_Homo sapiens_hsa041420.34105878
104Salivary secretion_Homo sapiens_hsa049700.33822153
105Amoebiasis_Homo sapiens_hsa051460.33511132
106Propanoate metabolism_Homo sapiens_hsa006400.33410092
107HIF-1 signaling pathway_Homo sapiens_hsa040660.32785795
108MicroRNAs in cancer_Homo sapiens_hsa052060.32628098
109MAPK signaling pathway_Homo sapiens_hsa040100.31079531
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.30300290
111Non-small cell lung cancer_Homo sapiens_hsa052230.29862272
112RNA degradation_Homo sapiens_hsa030180.28857878
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.28158020
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28103399
115Lysine degradation_Homo sapiens_hsa003100.27775433
116FoxO signaling pathway_Homo sapiens_hsa040680.25524530
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22898797
118Base excision repair_Homo sapiens_hsa034100.21910241
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21705383
120Glycerolipid metabolism_Homo sapiens_hsa005610.21073446
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20884710
122Prostate cancer_Homo sapiens_hsa052150.19841264
123Prion diseases_Homo sapiens_hsa050200.17876432
124mTOR signaling pathway_Homo sapiens_hsa041500.17001840
125Endocytosis_Homo sapiens_hsa041440.16568542
126Other glycan degradation_Homo sapiens_hsa005110.16445990
127Pathways in cancer_Homo sapiens_hsa052000.16060912
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15405027
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14715608
130Renal cell carcinoma_Homo sapiens_hsa052110.14353593
131Notch signaling pathway_Homo sapiens_hsa043300.13739818
132Fanconi anemia pathway_Homo sapiens_hsa034600.12533667
133Adherens junction_Homo sapiens_hsa045200.11957112
134Dorso-ventral axis formation_Homo sapiens_hsa043200.09565351
135Proteoglycans in cancer_Homo sapiens_hsa052050.09405268
136Rap1 signaling pathway_Homo sapiens_hsa040150.09254737
137Inositol phosphate metabolism_Homo sapiens_hsa005620.08567875
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.08544999
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07755053

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