IL13RA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.29112554
2detection of molecule of bacterial origin (GO:0032490)4.07072848
3peptidyl-glutamic acid carboxylation (GO:0017187)4.02238560
4protein carboxylation (GO:0018214)4.02238560
5L-phenylalanine catabolic process (GO:0006559)3.88742568
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.88742568
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.85293815
8desmosome organization (GO:0002934)3.76948240
9phospholipid efflux (GO:0033700)3.76770781
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.73301964
11L-phenylalanine metabolic process (GO:0006558)3.73301964
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72694843
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.72694843
14modulation by symbiont of host immune response (GO:0052553)3.72694843
15positive regulation by symbiont of host defense response (GO:0052509)3.72694843
16modulation by symbiont of host defense response (GO:0052031)3.72694843
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72694843
18bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62464207
19regulation of protein activation cascade (GO:2000257)3.58866034
20aromatic amino acid family catabolic process (GO:0009074)3.58763981
21detection of external biotic stimulus (GO:0098581)3.57594651
22high-density lipoprotein particle remodeling (GO:0034375)3.57376664
23complement activation, alternative pathway (GO:0006957)3.53902502
24regulation of complement activation (GO:0030449)3.45693827
25tryptophan catabolic process (GO:0006569)3.43476668
26indole-containing compound catabolic process (GO:0042436)3.43476668
27indolalkylamine catabolic process (GO:0046218)3.43476668
28macrophage activation involved in immune response (GO:0002281)3.39577890
29response to peptidoglycan (GO:0032494)3.37484929
30fibrinolysis (GO:0042730)3.35559497
31reverse cholesterol transport (GO:0043691)3.35082314
32regulation of cholesterol esterification (GO:0010872)3.34396027
33sulfur amino acid catabolic process (GO:0000098)3.33800776
34tryptophan metabolic process (GO:0006568)3.30860435
35kynurenine metabolic process (GO:0070189)3.28901744
36urea cycle (GO:0000050)3.26680426
37urea metabolic process (GO:0019627)3.26680426
38negative regulation of fibrinolysis (GO:0051918)3.24150704
39glyoxylate metabolic process (GO:0046487)3.23705918
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18401376
41neutrophil activation involved in immune response (GO:0002283)3.17567791
42amino-acid betaine metabolic process (GO:0006577)3.15957929
43antigen processing and presentation of endogenous antigen (GO:0019883)3.15390754
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14017455
45regulation of fibrinolysis (GO:0051917)3.11659189
46bile acid biosynthetic process (GO:0006699)3.11514858
47cellular glucuronidation (GO:0052695)3.11431364
48regulation of triglyceride catabolic process (GO:0010896)3.10071378
49detection of biotic stimulus (GO:0009595)3.09697213
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09283635
51phospholipid homeostasis (GO:0055091)3.01235903
52homocysteine metabolic process (GO:0050667)3.00910742
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98055725
54plasma lipoprotein particle remodeling (GO:0034369)2.96402597
55protein-lipid complex remodeling (GO:0034368)2.96402597
56macromolecular complex remodeling (GO:0034367)2.96402597
57bile acid and bile salt transport (GO:0015721)2.96302659
58cysteine metabolic process (GO:0006534)2.95871978
59nitrogen cycle metabolic process (GO:0071941)2.95825832
60glucuronate metabolic process (GO:0019585)2.95018986
61uronic acid metabolic process (GO:0006063)2.95018986
62plasma lipoprotein particle clearance (GO:0034381)2.92938013
63regulation of interferon-beta biosynthetic process (GO:0045357)2.90430182
64negative regulation of cell killing (GO:0031342)2.89125122
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89125122
66glycosphingolipid catabolic process (GO:0046479)2.89087003
67cholesterol efflux (GO:0033344)2.88433701
68alpha-linolenic acid metabolic process (GO:0036109)2.87573203
69regulation of cholesterol homeostasis (GO:2000188)2.86554396
70negative regulation of protein activation cascade (GO:2000258)2.86184022
71negative regulation of cholesterol transport (GO:0032375)2.83016748
72negative regulation of sterol transport (GO:0032372)2.83016748
73negative regulation of complement activation (GO:0045916)2.82101624
74carnitine metabolic process (GO:0009437)2.82062178
75cellular extravasation (GO:0045123)2.81254364
76lipoprotein metabolic process (GO:0042157)2.80976949
77protein localization to endosome (GO:0036010)2.79908639
78lysine metabolic process (GO:0006553)2.79770451
79lysine catabolic process (GO:0006554)2.79770451
80positive regulation of extracellular matrix organization (GO:1903055)2.78819516
81peptide catabolic process (GO:0043171)2.78672294
82positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.77292329
83negative regulation of interleukin-12 production (GO:0032695)2.73826659
84regulation of apoptotic cell clearance (GO:2000425)2.73652816
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72350435
86angiotensin maturation (GO:0002003)2.70970385
87pinocytosis (GO:0006907)2.70883867
88acute-phase response (GO:0006953)2.70712799
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.70704433
90ethanol oxidation (GO:0006069)2.70655580
91tyrosine metabolic process (GO:0006570)2.70353269
92bile acid metabolic process (GO:0008206)2.70008896
93positive regulation of cellular amide metabolic process (GO:0034250)2.69549885
94alkaloid metabolic process (GO:0009820)2.69545070
95benzene-containing compound metabolic process (GO:0042537)2.66592062
96drug catabolic process (GO:0042737)2.66591654
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66333360
98skin morphogenesis (GO:0043589)2.63353206
99barbed-end actin filament capping (GO:0051016)2.63256959
100glycolipid catabolic process (GO:0019377)2.63109484
101acylglycerol homeostasis (GO:0055090)2.62712676
102triglyceride homeostasis (GO:0070328)2.62712676
103ethanol metabolic process (GO:0006067)2.59914011
104negative regulation of lipase activity (GO:0060192)2.59808985
105opsonization (GO:0008228)2.59224570
106negative regulation of humoral immune response (GO:0002921)2.58752234
107complement activation (GO:0006956)2.58348654
108hypotonic response (GO:0006971)2.57621275
109positive regulation of lipid catabolic process (GO:0050996)2.57281288
110aromatic amino acid family metabolic process (GO:0009072)2.56839028
111production of molecular mediator involved in inflammatory response (GO:0002532)2.56673386
112low-density lipoprotein particle remodeling (GO:0034374)2.56531041
113very-low-density lipoprotein particle assembly (GO:0034379)2.54403481
114primary alcohol catabolic process (GO:0034310)2.53889723
115cholesterol homeostasis (GO:0042632)2.53862290
116positive regulation of leukocyte degranulation (GO:0043302)2.53475850
117flavonoid metabolic process (GO:0009812)2.53382994
118sterol homeostasis (GO:0055092)2.52211481
119hormone catabolic process (GO:0042447)2.52156561
120complement activation, classical pathway (GO:0006958)2.51709271
121plasma lipoprotein particle assembly (GO:0034377)2.51355845
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51046906
123negative regulation of blood coagulation (GO:0030195)2.50993333
124negative regulation of hemostasis (GO:1900047)2.50993333
125oligosaccharide catabolic process (GO:0009313)2.50392467
126positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.49667555
127intestinal cholesterol absorption (GO:0030299)2.48891198
128protein activation cascade (GO:0072376)2.48770627
129macrophage activation (GO:0042116)2.47896066
130xenobiotic catabolic process (GO:0042178)2.47527445
131regulation of leukocyte degranulation (GO:0043300)2.47479703
132positive regulation of fatty acid biosynthetic process (GO:0045723)2.47431504
133cellular modified amino acid catabolic process (GO:0042219)2.46437207
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45651721
135immunoglobulin mediated immune response (GO:0016064)2.45292817
136surfactant homeostasis (GO:0043129)2.45058582
137embryonic process involved in female pregnancy (GO:0060136)2.44724478
138cell adhesion mediated by integrin (GO:0033627)2.44652145
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.44645406
140response to host (GO:0075136)2.44645406
141response to host defenses (GO:0052200)2.44645406
142negative regulation of coagulation (GO:0050819)2.44645353
143epoxygenase P450 pathway (GO:0019373)2.44014748
144apoptotic cell clearance (GO:0043277)2.43889553
145indolalkylamine metabolic process (GO:0006586)2.43113780
146T-helper 1 type immune response (GO:0042088)2.42448287
147negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.41884124
148protein-lipid complex assembly (GO:0065005)2.41770348
149response to laminar fluid shear stress (GO:0034616)2.41755058
150detection of bacterium (GO:0016045)2.41031482
151negative regulation of fatty acid transport (GO:2000192)2.40754707
152drug transmembrane transport (GO:0006855)2.40614747
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40534191
154positive regulation of blood coagulation (GO:0030194)2.39767483
155positive regulation of hemostasis (GO:1900048)2.39767483
156regulation of macrophage chemotaxis (GO:0010758)2.39754625
157positive regulation of fatty acid beta-oxidation (GO:0032000)2.39236550
158regulation of T-helper 2 cell differentiation (GO:0045628)2.38880825
159detection of other organism (GO:0098543)2.38373778
160regulation of bile acid biosynthetic process (GO:0070857)2.37997779
161urate metabolic process (GO:0046415)2.37372180
162regulation of extracellular matrix disassembly (GO:0010715)2.37020397
163positive regulation of gamma-delta T cell activation (GO:0046645)2.35057659
164cellular response to thyroid hormone stimulus (GO:0097067)2.33740256
165regulation of mast cell degranulation (GO:0043304)2.33271419
166response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33112524
167response to host immune response (GO:0052572)2.33112524
168positive regulation of receptor recycling (GO:0001921)2.33048187
169regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.28819287
170positive regulation of coagulation (GO:0050820)2.28102193
171basement membrane organization (GO:0071711)2.28051952
172iron ion import (GO:0097286)2.27583178
173regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24954742
174low-density lipoprotein particle clearance (GO:0034383)2.21719731
175antigen processing and presentation via MHC class Ib (GO:0002475)2.21076796
176negative regulation of protein localization to plasma membrane (GO:1903077)2.21023062
177positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.20339319
178microglial cell activation (GO:0001774)2.19953023
179regulation of tolerance induction (GO:0002643)2.19770035
180regulation of T cell tolerance induction (GO:0002664)2.19007209
181regulation of macrophage cytokine production (GO:0010935)2.18381437
182positive regulation of phagocytosis (GO:0050766)2.16772090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.97718013
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.72622626
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.18779142
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.77209814
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74356748
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.60908779
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.24767052
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20364584
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.97766754
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.59509999
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.55321384
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32740049
13CLOCK_20551151_ChIP-Seq_293T_Human2.32704714
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.26885193
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26196476
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10472471
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07855726
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06487676
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02384878
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90961829
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86327003
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81711522
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.81199158
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81015392
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.77147611
26SOX2_20726797_ChIP-Seq_SW620_Human1.71237897
27GATA1_22025678_ChIP-Seq_K562_Human1.69288969
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.62788934
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.62422783
30SPI1_23127762_ChIP-Seq_K562_Human1.58852009
31CJUN_26792858_Chip-Seq_BT549_Human1.57978097
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53938083
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53327631
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52910955
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48656236
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48654699
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48654699
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48578052
39VDR_24763502_ChIP-Seq_THP-1_Human1.48401870
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47000046
41* IRF8_27001747_Chip-Seq_BMDM_Mouse1.45047816
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.44125610
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.42256202
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.41631879
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41480488
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39368119
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.37751033
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37640645
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37640645
50* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35577773
51GATA4_25053715_ChIP-Seq_YYC3_Human1.34537452
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33632924
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32473454
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31764002
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31257967
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27151246
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.26910337
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26529880
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26431232
60LXR_22292898_ChIP-Seq_THP-1_Human1.26170526
61* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24485565
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24370926
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21216737
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21022996
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20620881
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20046593
67TCF7_22412390_ChIP-Seq_EML_Mouse1.19470221
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18976498
69SPI1_23547873_ChIP-Seq_NB4_Human1.18788541
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18335385
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16759367
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.12550588
73* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11990260
74* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10280337
75VDR_21846776_ChIP-Seq_THP-1_Human1.09597824
76RUNX_20019798_ChIP-Seq_JUKART_Human1.08866752
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08432937
78PU_27001747_Chip-Seq_BMDM_Mouse1.08398912
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.07980220
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07386595
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06435754
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05180774
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03944667
84TP63_23658742_ChIP-Seq_EP156T_Human1.02395035
85EGR1_19032775_ChIP-ChIP_M12_Human1.01961817
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01881975
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01642342
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.01086306
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00251819
90* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99648612
91EP300_21415370_ChIP-Seq_HL-1_Mouse0.99573975
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99116555
93* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98071112
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97872381
95* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95441592
96TP53_18474530_ChIP-ChIP_U2OS_Human0.95265768
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95074548
98VDR_24787735_ChIP-Seq_THP-1_Human0.95037160
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94307145
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94107185
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93505420
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92431408
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92322818
104GATA6_25053715_ChIP-Seq_YYC3_Human0.90395137
105MAF_26560356_Chip-Seq_TH1_Human0.90214386
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86687600
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85276100
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.85121608
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.85121608
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84466986
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83599852
112ZNF263_19887448_ChIP-Seq_K562_Human0.83218333
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81545083
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81459697
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.80695022
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79980486
117RACK7_27058665_Chip-Seq_MCF-7_Human0.79740630
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79123136
119* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.79099595
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.77914516
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77534342
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76274440
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.75622910
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.74648661
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73885015
126BCAT_22108803_ChIP-Seq_LS180_Human0.73694929
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.73315387
128AHR_22903824_ChIP-Seq_MCF-7_Human0.72312223
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71628549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.29288425
2MP0002139_abnormal_hepatobiliary_system4.13868312
3MP0002254_reproductive_system_inflammat3.64510570
4MP0005085_abnormal_gallbladder_physiolo3.41926543
5MP0005365_abnormal_bile_salt3.01690618
6MP0008875_abnormal_xenobiotic_pharmacok2.89897024
7MP0003191_abnormal_cellular_cholesterol2.72661786
8MP0003705_abnormal_hypodermis_morpholog2.60641151
9MP0005275_abnormal_skin_tensile2.59558943
10MP0003252_abnormal_bile_duct2.58045067
11MP0009840_abnormal_foam_cell2.54542522
12MP0008438_abnormal_cutaneous_collagen2.30279995
13MP0002796_impaired_skin_barrier2.27399588
14MP0010234_abnormal_vibrissa_follicle2.26289176
15MP0002138_abnormal_hepatobiliary_system2.26288080
16MP0003195_calcinosis2.08415050
17MP0001666_abnormal_nutrient_absorption1.88978945
18MP0002060_abnormal_skin_morphology1.88297268
19MP0010329_abnormal_lipoprotein_level1.82194052
20MP0003724_increased_susceptibility_to1.78990264
21MP0003453_abnormal_keratinocyte_physiol1.76830643
22MP0003300_gastrointestinal_ulcer1.74665500
23MP0003172_abnormal_lysosome_physiology1.72377601
24MP0003183_abnormal_peptide_metabolism1.66864399
25MP0004019_abnormal_vitamin_homeostasis1.64771623
26MP0003566_abnormal_cell_adhesion1.64756915
27MP0008260_abnormal_autophagy1.64329775
28MP0005083_abnormal_biliary_tract1.59063665
29MP0003436_decreased_susceptibility_to1.58042380
30MP0000858_altered_metastatic_potential1.54524011
31MP0003806_abnormal_nucleotide_metabolis1.52754574
32MP0003091_abnormal_cell_migration1.52413797
33MP0009764_decreased_sensitivity_to1.51413508
34MP0005409_darkened_coat_color1.43454922
35MP0005332_abnormal_amino_acid1.42576827
36MP0004947_skin_inflammation1.41350132
37MP0005023_abnormal_wound_healing1.40763187
38MP0010368_abnormal_lymphatic_system1.36060837
39MP0000604_amyloidosis1.34233845
40MP0004272_abnormal_basement_membrane1.34033877
41MP0001346_abnormal_lacrimal_gland1.32886447
42MP0001216_abnormal_epidermal_layer1.32647815
43MP0004782_abnormal_surfactant_physiolog1.30532209
44MP0010678_abnormal_skin_adnexa1.29522197
45MP0000609_abnormal_liver_physiology1.29322521
46MP0003941_abnormal_skin_development1.27756997
47MP0000383_abnormal_hair_follicle1.27747581
48MP0005000_abnormal_immune_tolerance1.26911770
49MP0004883_abnormal_blood_vessel1.26316304
50MP0000579_abnormal_nail_morphology1.23755415
51MP0005257_abnormal_intraocular_pressure1.23432955
52MP0003448_altered_tumor_morphology1.21052656
53MP0001835_abnormal_antigen_presentation1.19648769
54MP0002148_abnormal_hypersensitivity_rea1.18299554
55MP0009643_abnormal_urine_homeostasis1.18225853
56MP0009384_cardiac_valve_regurgitation1.17736920
57MP0001533_abnormal_skeleton_physiology1.15486718
58* MP0002452_abnormal_antigen_presenting1.13387290
59MP0005503_abnormal_tendon_morphology1.13289448
60MP0002098_abnormal_vibrissa_morphology1.12072670
61MP0009785_altered_susceptibility_to1.11703881
62MP0004264_abnormal_extraembryonic_tissu1.11507808
63MP0005319_abnormal_enzyme/_coenzyme1.10557132
64MP0005501_abnormal_skin_physiology1.09648699
65MP0002118_abnormal_lipid_homeostasis1.09129595
66MP0000767_abnormal_smooth_muscle1.08603992
67MP0003279_aneurysm1.08321792
68* MP0002723_abnormal_immune_serum1.06181257
69MP0010352_gastrointestinal_tract_polyps1.06166562
70MP0002896_abnormal_bone_mineralization1.05105758
71MP0002405_respiratory_system_inflammati1.02749297
72MP0003690_abnormal_glial_cell1.02487569
73MP0002295_abnormal_pulmonary_circulatio1.01780828
74* MP0001800_abnormal_humoral_immune1.01096241
75MP0000465_gastrointestinal_hemorrhage1.00803135
76MP0002132_abnormal_respiratory_system1.00688937
77MP0001853_heart_inflammation1.00218250
78MP0004858_abnormal_nervous_system0.99789198
79MP0002166_altered_tumor_susceptibility0.99442541
80MP0005076_abnormal_cell_differentiation0.99179478
81MP0006082_CNS_inflammation0.97177195
82MP0000249_abnormal_blood_vessel0.96485723
83MP0005390_skeleton_phenotype0.96373790
84MP0009053_abnormal_anal_canal0.95669341
85MP0010155_abnormal_intestine_physiology0.94185238
86* MP0008469_abnormal_protein_level0.93776107
87MP0003868_abnormal_feces_composition0.93422211
88MP0000467_abnormal_esophagus_morphology0.93144626
89MP0002419_abnormal_innate_immunity0.92892197
90* MP0001819_abnormal_immune_cell0.92837388
91MP0001915_intracranial_hemorrhage0.92571039
92MP0008004_abnormal_stomach_pH0.92205593
93* MP0002420_abnormal_adaptive_immunity0.91919144
94MP0001958_emphysema0.91683458
95MP0001243_abnormal_dermal_layer0.90994604
96MP0003075_altered_response_to0.90363397
97MP0001849_ear_inflammation0.89653828
98MP0000538_abnormal_urinary_bladder0.89637040
99MP0000343_altered_response_to0.89219019
100MP0005451_abnormal_body_composition0.88966712
101MP0010771_integument_phenotype0.88554768
102MP0005164_abnormal_response_to0.88021223
103MP0002136_abnormal_kidney_physiology0.87324915
104MP0004510_myositis0.86896333
105MP0001879_abnormal_lymphatic_vessel0.85412707
106MP0000685_abnormal_immune_system0.85197343
107MP0009763_increased_sensitivity_to0.84852195
108MP0003329_amyloid_beta_deposits0.84436990
109MP0003303_peritoneal_inflammation0.83977167
110MP0004381_abnormal_hair_follicle0.83804042
111MP0003866_abnormal_defecation0.82694860
112MP0001845_abnormal_inflammatory_respons0.81821684
113MP0001851_eye_inflammation0.81762546
114MP0002933_joint_inflammation0.81718532
115MP0003186_abnormal_redox_activity0.80840257
116MP0000377_abnormal_hair_follicle0.80636474
117MP0006054_spinal_hemorrhage0.80583423
118MP0001756_abnormal_urination0.80485225
119MP0005387_immune_system_phenotype0.80188424
120MP0001790_abnormal_immune_system0.80188424
121MP0003828_pulmonary_edema0.79928964
122* MP0005025_abnormal_response_to0.79859024
123MP0003795_abnormal_bone_structure0.79783858
124MP0005584_abnormal_enzyme/coenzyme_acti0.78916230
125MP0002971_abnormal_brown_adipose0.77314033
126MP0005165_increased_susceptibility_to0.77027724
127MP0005058_abnormal_lysosome_morphology0.76883262
128MP0002877_abnormal_melanocyte_morpholog0.75832771
129MP0001191_abnormal_skin_condition0.75814682
130MP0002998_abnormal_bone_remodeling0.75187664
131MP0005166_decreased_susceptibility_to0.74183286
132MP0005464_abnormal_platelet_physiology0.74045772
133MP0005167_abnormal_blood-brain_barrier0.73982966
134MP0001542_abnormal_bone_strength0.72311322
135MP0000427_abnormal_hair_cycle0.71691322
136MP0009931_abnormal_skin_appearance0.71597637

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.48956861
2Deep venous thrombosis (HP:0002625)4.36727798
3Xanthomatosis (HP:0000991)4.23170981
4Intrahepatic cholestasis (HP:0001406)4.07035770
5Complement deficiency (HP:0004431)4.06756134
6Systemic lupus erythematosus (HP:0002725)3.96053459
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.72193288
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54700954
9Abnormality of complement system (HP:0005339)3.51159171
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50702774
11Prolonged partial thromboplastin time (HP:0003645)3.42979879
12Abnormality of glycolipid metabolism (HP:0010969)3.41402804
13Abnormality of liposaccharide metabolism (HP:0010968)3.41402804
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.41402804
15Abnormality of macrophages (HP:0004311)3.40604551
16Atrophic scars (HP:0001075)3.35021377
17Thick nail (HP:0001805)3.30944996
18Abnormality of the common coagulation pathway (HP:0010990)3.23636306
19Plantar hyperkeratosis (HP:0007556)3.23554462
20Myocardial infarction (HP:0001658)3.22377049
21Onycholysis (HP:0001806)3.15344209
22Glomerulonephritis (HP:0000099)3.14319062
23Joint hemorrhage (HP:0005261)3.12761919
24Recurrent abscess formation (HP:0002722)3.09609079
25Hypobetalipoproteinemia (HP:0003563)3.01219566
26Hypoalphalipoproteinemia (HP:0003233)3.00536558
27Eczematoid dermatitis (HP:0000976)2.99151209
28Recurrent bacterial skin infections (HP:0005406)2.98264125
29Nephritis (HP:0000123)2.94566000
30Arterial tortuosity (HP:0005116)2.93882988
31Milia (HP:0001056)2.92864831
32Hyperlipoproteinemia (HP:0010980)2.87643604
33Myositis (HP:0100614)2.86077427
34Abnormality of proline metabolism (HP:0010907)2.85916009
35Hydroxyprolinuria (HP:0003080)2.85916009
36Hypolipoproteinemia (HP:0010981)2.85605519
37Cardiovascular calcification (HP:0011915)2.83899027
38Alopecia of scalp (HP:0002293)2.83848013
39Vascular tortuosity (HP:0004948)2.81335355
40Hypoglycemic coma (HP:0001325)2.81036547
41Peritonitis (HP:0002586)2.80314767
42Dysostosis multiplex (HP:0000943)2.79728633
43Vertebral compression fractures (HP:0002953)2.79367668
44Vascular calcification (HP:0004934)2.76452134
45Fragile nails (HP:0001808)2.74003572
46Epidermoid cyst (HP:0200040)2.72697355
47Mucopolysacchariduria (HP:0008155)2.71397785
48Urinary glycosaminoglycan excretion (HP:0003541)2.71397785
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65708415
50Esophageal varix (HP:0002040)2.64790960
51Osteolytic defects of the hand bones (HP:0009699)2.63893257
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.63893257
53Amyloidosis (HP:0011034)2.60706624
54Gingivitis (HP:0000230)2.58925796
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57108664
56Abnormality of polysaccharide metabolism (HP:0011012)2.57108664
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57108664
58Abnormality of the intrinsic pathway (HP:0010989)2.56263298
59Recurrent gram-negative bacterial infections (HP:0005420)2.53460007
60Fat malabsorption (HP:0002630)2.51089258
61Premature rupture of membranes (HP:0001788)2.49591062
62Spontaneous hematomas (HP:0007420)2.48899741
63Palmoplantar hyperkeratosis (HP:0000972)2.44233634
64Gastrointestinal infarctions (HP:0005244)2.42806439
65Hyperammonemia (HP:0001987)2.40535482
66Optic neuritis (HP:0100653)2.40229476
67Retrobulbar optic neuritis (HP:0100654)2.40229476
68Flat acetabular roof (HP:0003180)2.35918277
69Conjugated hyperbilirubinemia (HP:0002908)2.34163803
70Mitral stenosis (HP:0001718)2.29438408
71Hypercholesterolemia (HP:0003124)2.28923109
72Hepatocellular carcinoma (HP:0001402)2.28008178
73Loss of speech (HP:0002371)2.25515128
74Hematochezia (HP:0002573)2.23490171
75Purpura (HP:0000979)2.22858572
76Palmar hyperkeratosis (HP:0010765)2.21866882
77Abnormality of purine metabolism (HP:0004352)2.18007030
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17694042
79Ketosis (HP:0001946)2.17420130
80Spondylolisthesis (HP:0003302)2.16694642
81Cervical subluxation (HP:0003308)2.13358938
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.13051400
83Dilatation of the ascending aorta (HP:0005111)2.12894062
84Increased cerebral lipofuscin (HP:0011813)2.09624559
85Abnormality of the peritoneum (HP:0002585)2.07769385
86Interstitial pulmonary disease (HP:0006530)2.06826039
87Aneurysm (HP:0002617)2.05564508
88Thin bony cortex (HP:0002753)2.04557260
89Axonal loss (HP:0003447)2.04412168
90Protrusio acetabuli (HP:0003179)2.03185366
91Abnormality of fatty-acid metabolism (HP:0004359)2.02456881
92Autoimmune thrombocytopenia (HP:0001973)1.99358453
93Ketoacidosis (HP:0001993)1.99305054
94Recurrent skin infections (HP:0001581)1.98732882
95Hyperglycinuria (HP:0003108)1.96234771
96Woolly hair (HP:0002224)1.96072183
97Ventricular tachycardia (HP:0004756)1.95481524
98Skin nodule (HP:0200036)1.94391338
99Asymmetric septal hypertrophy (HP:0001670)1.94130286
100Fragile skin (HP:0001030)1.91898011
101Hypotrichosis (HP:0001006)1.89630039
102Distal lower limb muscle weakness (HP:0009053)1.89569396
103Aortic dissection (HP:0002647)1.88985327
104Abnormality of nucleobase metabolism (HP:0010932)1.87341967
105Ileus (HP:0002595)1.87235813
106Abnormal hemoglobin (HP:0011902)1.85118784
107Pathologic fracture (HP:0002756)1.84966756
108Hemorrhage of the eye (HP:0011885)1.83899642
109Orchitis (HP:0100796)1.82890980
110Ovoid vertebral bodies (HP:0003300)1.82552972
111Keratoconjunctivitis sicca (HP:0001097)1.80698688
112Epistaxis (HP:0000421)1.79559868
113Bone pain (HP:0002653)1.78730440
114Hypoglycemic seizures (HP:0002173)1.77878311
115Nail dystrophy (HP:0008404)1.77682398
116Aortic aneurysm (HP:0004942)1.77632206
117Thrombophlebitis (HP:0004418)1.77490665
118Abnormality of carpal bone ossification (HP:0006257)1.77275204
119Pulmonary infiltrates (HP:0002113)1.76744545
120Mediastinal lymphadenopathy (HP:0100721)1.76715413
121Polycythemia (HP:0001901)1.76218615
122Steatorrhea (HP:0002570)1.76169897
123Neurofibrillary tangles (HP:0002185)1.76145836
124Abnormality of methionine metabolism (HP:0010901)1.75918661
125Periodontitis (HP:0000704)1.75892709
126Urticaria (HP:0001025)1.75836424
127Tetraparesis (HP:0002273)1.75762936
128Gingival bleeding (HP:0000225)1.75556452
129Blue sclerae (HP:0000592)1.74577424
130Pulmonary embolism (HP:0002204)1.73130100
131Segmental peripheral demyelination/remyelination (HP:0003481)1.73117687
132Hemoptysis (HP:0002105)1.73097629
133Acanthosis nigricans (HP:0000956)1.72629760
134Abnormality of glycine metabolism (HP:0010895)1.72423843
135Abnormality of serine family amino acid metabolism (HP:0010894)1.72423843
136Obstructive lung disease (HP:0006536)1.71353481
137Chronic obstructive pulmonary disease (HP:0006510)1.71353481
138Malnutrition (HP:0004395)1.71104021
139Spontaneous abortion (HP:0005268)1.68349520
140Increased connective tissue (HP:0009025)1.68156620
141Focal segmental glomerulosclerosis (HP:0000097)1.66638344
142Arterial thrombosis (HP:0004420)1.66638202
143Gout (HP:0001997)1.65050760
144Wormian bones (HP:0002645)1.65005024
145Nonimmune hydrops fetalis (HP:0001790)1.64922069
146Subacute progressive viral hepatitis (HP:0006572)1.64643394
147Cheilitis (HP:0100825)1.63272328
148Increased IgE level (HP:0003212)1.63121930
149Abnormal cartilage morphology (HP:0002763)1.63029937
150Pustule (HP:0200039)1.61699017
151Cerebral aneurysm (HP:0004944)1.61277291
152Vacuolated lymphocytes (HP:0001922)1.61061655
153Pancreatitis (HP:0001733)1.60540310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.75573688
2MST1R3.26930886
3FRK2.82692404
4TGFBR22.76143825
5FGFR42.66795385
6MAP3K142.65747956
7EPHA32.51392961
8MAP3K32.34275050
9EPHB12.13856019
10RIPK42.09770120
11INSRR1.95127978
12TBK11.90367991
13PRPF4B1.86316918
14PTK61.81270890
15ZAP701.74582758
16FER1.71614102
17TRPM71.70193648
18JAK11.68081361
19RIPK11.63808634
20EPHA21.62282288
21NEK91.60834408
22LATS11.56671581
23SIK11.54174585
24BCKDK1.49804259
25MET1.48867145
26PKN21.46825092
27KSR21.46816895
28TTN1.43242296
29MST41.39797776
30MAP3K21.38036362
31MAPK151.35038411
32TRIB31.33677708
33* TYK21.32292126
34CDC42BPA1.31579703
35EPHB21.27388760
36IKBKE1.27090032
37FGR1.22051560
38FGFR31.21001659
39KDR1.20021302
40PIK3CG1.19627441
41IKBKB1.17175755
42TIE11.15431146
43PDGFRA1.14014000
44PDPK11.13662517
45PTK21.13591078
46MYLK1.13148278
47ERBB31.10804754
48JAK21.09037487
49FLT31.07591290
50MAP3K61.06642803
51YES11.05816180
52IRAK31.05681649
53LRRK21.05428842
54MAPKAPK31.02523580
55MAP2K20.99212318
56TGFBR10.99073893
57FGFR20.98446884
58STK240.97792890
59CHUK0.95151319
60BLK0.94475213
61CSK0.92860179
62STK38L0.92325287
63MAP3K120.89883027
64JAK30.88250642
65ACVR1B0.85620898
66MATK0.85021919
67MAP3K130.85002360
68TAOK10.83689011
69ICK0.83680641
70ERBB40.82953018
71MAP2K10.82466799
72LMTK20.81910144
73HCK0.81741530
74RET0.80042295
75BMX0.79709519
76PDK10.78834635
77STK100.78815791
78STK30.76623621
79MAP3K110.76506845
80DYRK1B0.75973843
81MAP2K30.74965553
82SMG10.74349844
83FES0.73293481
84MAP3K10.72367960
85NUAK10.71935088
86TAOK20.71745343
87NLK0.71425144
88CDK120.69604382
89GRK70.69478157
90PRKAA20.69115208
91GRK60.68979012
92CDK60.68189053
93PRKD20.67370950
94BMPR1B0.67329455
95LATS20.66766139
96RPS6KA40.66683959
97ABL20.66644377
98TAOK30.65198988
99DDR20.64742788
100IRAK40.64052824
101IRAK20.63873563
102MAP4K10.62835604
103STK380.62507588
104GSK3A0.61553284
105PIK3CA0.59711077
106PAK40.59280122
107MAPKAPK20.57019620
108MAP3K70.56230245
109PDK20.55462827
110KIT0.54909413
111PBK0.54543257
112PAK30.53661369
113IRAK10.53414222
114MARK20.53230498
115PIM20.52821684
116PRKG20.51544250
117MAPK110.50497159
118MAPK70.49966109
119GRK10.49660001
120KSR10.49644763
121SIK30.49584142
122SGK30.49375360
123DMPK0.49036431
124TESK10.48857226
125IGF1R0.48334254
126BTK0.47897974
127LYN0.46833327
128BMPR20.46441042
129MELK0.44535277
130PDGFRB0.41469680
131EGFR0.41293961
132MOS0.40990630
133LCK0.40765760
134ERBB20.39987971
135WNK40.39560856
136MAPKAPK50.38801325
137ABL10.38633685
138CSF1R0.37757368

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.18806668
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.98119978
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73215653
4Complement and coagulation cascades_Homo sapiens_hsa046102.70513134
5Staphylococcus aureus infection_Homo sapiens_hsa051502.55743618
6Nitrogen metabolism_Homo sapiens_hsa009102.33909638
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32908064
8Fatty acid degradation_Homo sapiens_hsa000712.26489754
9Tryptophan metabolism_Homo sapiens_hsa003802.24236841
10Caffeine metabolism_Homo sapiens_hsa002322.21282823
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21249723
12Arginine biosynthesis_Homo sapiens_hsa002202.19440423
13Histidine metabolism_Homo sapiens_hsa003402.08326992
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01332234
15Chemical carcinogenesis_Homo sapiens_hsa052042.01054343
16Phenylalanine metabolism_Homo sapiens_hsa003601.78588704
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70539353
18PPAR signaling pathway_Homo sapiens_hsa033201.65739770
19Sulfur metabolism_Homo sapiens_hsa009201.65195547
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.57309777
21Peroxisome_Homo sapiens_hsa041461.53538554
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53464429
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.53214795
24Retinol metabolism_Homo sapiens_hsa008301.46314527
25Starch and sucrose metabolism_Homo sapiens_hsa005001.41612681
26Fatty acid metabolism_Homo sapiens_hsa012121.41071119
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40239531
28beta-Alanine metabolism_Homo sapiens_hsa004101.40018595
29Phagosome_Homo sapiens_hsa041451.32350327
30Tyrosine metabolism_Homo sapiens_hsa003501.30480540
31Bile secretion_Homo sapiens_hsa049761.28985379
32Fat digestion and absorption_Homo sapiens_hsa049751.28414465
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20759492
34Propanoate metabolism_Homo sapiens_hsa006401.20576632
35ABC transporters_Homo sapiens_hsa020101.19272397
36Butanoate metabolism_Homo sapiens_hsa006501.16916226
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12671992
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10720581
39Allograft rejection_Homo sapiens_hsa053301.07528876
40Vitamin digestion and absorption_Homo sapiens_hsa049771.02349346
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01911171
42Graft-versus-host disease_Homo sapiens_hsa053321.00113191
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.99137185
44Autoimmune thyroid disease_Homo sapiens_hsa053200.96852999
45Acute myeloid leukemia_Homo sapiens_hsa052210.95319613
46Glutathione metabolism_Homo sapiens_hsa004800.94192244
47B cell receptor signaling pathway_Homo sapiens_hsa046620.92140489
48Salmonella infection_Homo sapiens_hsa051320.91440974
49Pancreatic cancer_Homo sapiens_hsa052120.91093248
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.91009607
51Hematopoietic cell lineage_Homo sapiens_hsa046400.90976971
52Viral myocarditis_Homo sapiens_hsa054160.90700387
53ECM-receptor interaction_Homo sapiens_hsa045120.89248861
54Chronic myeloid leukemia_Homo sapiens_hsa052200.87782116
55Chemokine signaling pathway_Homo sapiens_hsa040620.86473204
56Malaria_Homo sapiens_hsa051440.84918419
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84783787
58Selenocompound metabolism_Homo sapiens_hsa004500.84537774
59Amoebiasis_Homo sapiens_hsa051460.82530862
60Leishmaniasis_Homo sapiens_hsa051400.81652276
61Pertussis_Homo sapiens_hsa051330.81419402
62Antigen processing and presentation_Homo sapiens_hsa046120.81393773
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81392277
64Renal cell carcinoma_Homo sapiens_hsa052110.79578669
65Toxoplasmosis_Homo sapiens_hsa051450.79053687
66Folate biosynthesis_Homo sapiens_hsa007900.78438365
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77128799
68Rheumatoid arthritis_Homo sapiens_hsa053230.77103408
69Fatty acid elongation_Homo sapiens_hsa000620.76960059
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.75332009
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75331347
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74596772
73Asthma_Homo sapiens_hsa053100.73877138
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73867825
75Measles_Homo sapiens_hsa051620.72893548
76TNF signaling pathway_Homo sapiens_hsa046680.72736117
77Platelet activation_Homo sapiens_hsa046110.70579474
78Shigellosis_Homo sapiens_hsa051310.70318813
79Fructose and mannose metabolism_Homo sapiens_hsa000510.70212682
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70198708
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69962876
82Non-small cell lung cancer_Homo sapiens_hsa052230.68537390
83Bladder cancer_Homo sapiens_hsa052190.68131131
84Mineral absorption_Homo sapiens_hsa049780.66916636
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64937575
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63942821
87Type I diabetes mellitus_Homo sapiens_hsa049400.63165879
88Hepatitis B_Homo sapiens_hsa051610.62793020
89Insulin resistance_Homo sapiens_hsa049310.62666103
90* Jak-STAT signaling pathway_Homo sapiens_hsa046300.61769096
91Legionellosis_Homo sapiens_hsa051340.61350982
92Prolactin signaling pathway_Homo sapiens_hsa049170.60108286
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59592627
94Osteoclast differentiation_Homo sapiens_hsa043800.58856320
95Sphingolipid metabolism_Homo sapiens_hsa006000.58814071
96Apoptosis_Homo sapiens_hsa042100.58742112
97Pyruvate metabolism_Homo sapiens_hsa006200.58682748
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58659255
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56711266
100VEGF signaling pathway_Homo sapiens_hsa043700.56525025
101* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56440190
102Endocytosis_Homo sapiens_hsa041440.56311870
103Arginine and proline metabolism_Homo sapiens_hsa003300.56248418
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55775094
105Adherens junction_Homo sapiens_hsa045200.55685206
106Lysosome_Homo sapiens_hsa041420.55223379
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.54952318
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.54804479
109Arachidonic acid metabolism_Homo sapiens_hsa005900.53791092
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53144957
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.52854271
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52549652
113Carbon metabolism_Homo sapiens_hsa012000.52136011
114Herpes simplex infection_Homo sapiens_hsa051680.51475566
115Protein digestion and absorption_Homo sapiens_hsa049740.51399522
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49988016
117Focal adhesion_Homo sapiens_hsa045100.49334675
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.48026030
119Hepatitis C_Homo sapiens_hsa051600.47808682
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47719512
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.47674280
122Renin-angiotensin system_Homo sapiens_hsa046140.47133470
123African trypanosomiasis_Homo sapiens_hsa051430.46400830
124Prion diseases_Homo sapiens_hsa050200.46137208
125Lysine degradation_Homo sapiens_hsa003100.41114482
126Proteoglycans in cancer_Homo sapiens_hsa052050.39536960
127Other glycan degradation_Homo sapiens_hsa005110.39075931
128Galactose metabolism_Homo sapiens_hsa000520.38698378
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38589821
130Influenza A_Homo sapiens_hsa051640.38292630
131Small cell lung cancer_Homo sapiens_hsa052220.37981884
132Steroid biosynthesis_Homo sapiens_hsa001000.37486185
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36789016
134Tuberculosis_Homo sapiens_hsa051520.35849833
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35723724
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34325028
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33957094
138Glycerolipid metabolism_Homo sapiens_hsa005610.31327002
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31090052
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30117936

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