IL13RA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of homotypic cell-cell adhesion (GO:0034111)7.00784173
2regulation of plasminogen activation (GO:0010755)6.78396626
3negative regulation of sodium ion transport (GO:0010766)6.70741078
4negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)6.04119928
5regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.58197196
6lymph vessel development (GO:0001945)5.47274059
7regulation of timing of cell differentiation (GO:0048505)5.43050989
8regulation of gonadotropin secretion (GO:0032276)5.36344503
9cellular response to vitamin D (GO:0071305)5.15159702
10lymphangiogenesis (GO:0001946)5.13715723
11positive regulation of protein kinase C signaling (GO:0090037)4.97272369
12regulation of development, heterochronic (GO:0040034)4.75887760
13regulation of lipoprotein metabolic process (GO:0050746)4.72429662
14regulation of cytokine production involved in inflammatory response (GO:1900015)4.69307125
15negative regulation of adherens junction organization (GO:1903392)4.68354272
16negative regulation of focal adhesion assembly (GO:0051895)4.68354272
17negative regulation of cell junction assembly (GO:1901889)4.68354272
18negative regulation of leukocyte chemotaxis (GO:0002689)4.55188321
19cell migration involved in sprouting angiogenesis (GO:0002042)4.43001292
20vascular endothelial growth factor signaling pathway (GO:0038084)4.41165654
21axon regeneration (GO:0031103)4.28406342
22Golgi transport vesicle coating (GO:0048200)4.22823821
23COPI coating of Golgi vesicle (GO:0048205)4.22823821
24lung vasculature development (GO:0060426)4.19531084
25regulation of platelet aggregation (GO:0090330)4.18679798
26righting reflex (GO:0060013)4.11773549
27diterpenoid biosynthetic process (GO:0016102)4.05869083
28hypotonic response (GO:0006971)3.97315608
29type B pancreatic cell proliferation (GO:0044342)3.95789854
30regulation of response to osmotic stress (GO:0047484)3.89975411
31negative regulation of catenin import into nucleus (GO:0035414)3.86683620
32enteric nervous system development (GO:0048484)3.85911022
33basement membrane organization (GO:0071711)3.84225564
34endothelial cell morphogenesis (GO:0001886)3.80498720
35positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.79852635
36dermatan sulfate biosynthetic process (GO:0030208)3.76580131
37cellular response to vitamin (GO:0071295)3.70530594
38blood vessel endothelial cell migration (GO:0043534)3.67284245
39interleukin-6-mediated signaling pathway (GO:0070102)3.59656999
40neuron remodeling (GO:0016322)3.55178217
41dermatan sulfate metabolic process (GO:0030205)3.52110083
42cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.45454611
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43087718
44L-phenylalanine catabolic process (GO:0006559)3.43087718
45negative regulation of fibrinolysis (GO:0051918)3.40779885
46mesenchymal-epithelial cell signaling (GO:0060638)3.40372066
47positive regulation vascular endothelial growth factor production (GO:0010575)3.39928489
48endothelial cell chemotaxis (GO:0035767)3.34047306
49peptidyl-proline hydroxylation (GO:0019511)3.32174889
50mesodermal cell differentiation (GO:0048333)3.31579390
51cell adhesion mediated by integrin (GO:0033627)3.27077477
52chondrocyte proliferation (GO:0035988)3.26677453
53metanephric mesenchyme development (GO:0072075)3.26413674
54protein heterotrimerization (GO:0070208)3.25780947
55glial cell migration (GO:0008347)3.24777807
56substrate-dependent cell migration (GO:0006929)3.23267049
57secretory granule organization (GO:0033363)3.22638057
58negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.20362508
59regulation of fibrinolysis (GO:0051917)3.18626792
60protein carboxylation (GO:0018214)3.18415338
61peptidyl-glutamic acid carboxylation (GO:0017187)3.18415338
62axon development (GO:0061564)3.16819469
63positive regulation of astrocyte differentiation (GO:0048711)3.15922421
64protein hydroxylation (GO:0018126)3.15638072
65axon extension involved in axon guidance (GO:0048846)3.15575986
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.15575986
67hyaluronan metabolic process (GO:0030212)3.14640151
68skin morphogenesis (GO:0043589)3.12672134
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11783240
70L-phenylalanine metabolic process (GO:0006558)3.11783240
71neuron projection regeneration (GO:0031102)3.11213394
72cranial nerve morphogenesis (GO:0021602)3.10739340
73regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.08864163
74barbed-end actin filament capping (GO:0051016)3.08143051
75regulation of homotypic cell-cell adhesion (GO:0034110)3.04481084
76chondroitin sulfate catabolic process (GO:0030207)3.04079853
77cartilage condensation (GO:0001502)3.03021099
78cell aggregation (GO:0098743)3.03021099
79UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01511950
80neurotransmitter catabolic process (GO:0042135)2.99413616
81innervation (GO:0060384)2.99319894
82outer ear morphogenesis (GO:0042473)2.98094431
83negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.98046171
84sequestering of actin monomers (GO:0042989)2.97901294
85kidney mesenchyme development (GO:0072074)2.91206226
86terpenoid biosynthetic process (GO:0016114)2.89504594
87ventricular cardiac muscle cell development (GO:0055015)2.89313381
88negative regulation of chemokine production (GO:0032682)2.89282363
89neural crest cell migration (GO:0001755)2.85479853
90peripheral nervous system development (GO:0007422)2.85011150
91positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.83745516
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82940548
93regulation of vascular endothelial growth factor production (GO:0010574)2.82142576
94aromatic amino acid family catabolic process (GO:0009074)2.81925713
95transcytosis (GO:0045056)2.80845882
96negative regulation of lipase activity (GO:0060192)2.79862969
97glomerular basement membrane development (GO:0032836)2.79584511
98glomerular visceral epithelial cell development (GO:0072015)2.77997928
99high-density lipoprotein particle remodeling (GO:0034375)2.77844326
100positive regulation of neuroblast proliferation (GO:0002052)2.77839783
101opsonization (GO:0008228)2.73799686
102mesenchymal cell differentiation involved in renal system development (GO:2001012)2.73451733
103mesenchymal cell differentiation involved in kidney development (GO:0072161)2.73451733
104renal filtration (GO:0097205)2.71789359
105neuron recognition (GO:0008038)2.70661293
106axonal fasciculation (GO:0007413)2.70654702
107regulation of astrocyte differentiation (GO:0048710)2.69686916
108response to redox state (GO:0051775)2.68603405
109triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.68293751
110artery smooth muscle contraction (GO:0014824)2.68253937
111response to gravity (GO:0009629)2.67765721
112regulation of protein kinase C signaling (GO:0090036)2.67543202
113blood coagulation, intrinsic pathway (GO:0007597)2.66309306
114negative regulation of osteoblast proliferation (GO:0033689)2.65953105
115muscle cell migration (GO:0014812)2.63923154
116regulation of adherens junction organization (GO:1903391)2.63584592
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63188477
118regulation of integrin-mediated signaling pathway (GO:2001044)2.62475818
119hyaluronan catabolic process (GO:0030214)2.61632287
120COPII vesicle coating (GO:0048208)2.61051908
121regulation of monocyte chemotaxis (GO:0090025)2.61004438
122regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.60597703
123fibrinolysis (GO:0042730)2.60515997
124positive regulation of receptor internalization (GO:0002092)2.59757320
125endothelium development (GO:0003158)2.59724061
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.58912198
127regulation of protein activation cascade (GO:2000257)2.57904555
128reverse cholesterol transport (GO:0043691)2.57078357
129regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.56510492
130glucosamine-containing compound catabolic process (GO:1901072)2.56468913
131cellular response to prostaglandin stimulus (GO:0071379)2.56431690
132hyperosmotic salinity response (GO:0042538)2.55867512
133negative regulation of bone mineralization (GO:0030502)2.54140341
134regulation of focal adhesion assembly (GO:0051893)2.54055061
135regulation of cell-substrate junction assembly (GO:0090109)2.54055061
136membrane protein ectodomain proteolysis (GO:0006509)2.53928810
137endodermal cell differentiation (GO:0035987)2.53269135
138hemidesmosome assembly (GO:0031581)2.53093267
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52252514
140protein retention in ER lumen (GO:0006621)2.52078462
141coenzyme catabolic process (GO:0009109)2.51609868
142drug catabolic process (GO:0042737)2.51051253
143sequestering of extracellular ligand from receptor (GO:0035581)2.50616575
144tonic smooth muscle contraction (GO:0014820)2.50485326
145chondroitin sulfate biosynthetic process (GO:0030206)2.49180380
146negative regulation of platelet activation (GO:0010544)2.48523802
147positive regulation of osteoblast proliferation (GO:0033690)2.48349297
148embryonic cranial skeleton morphogenesis (GO:0048701)2.47869009
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47851584
150indole-containing compound catabolic process (GO:0042436)2.47541814
151indolalkylamine catabolic process (GO:0046218)2.47541814
152tryptophan catabolic process (GO:0006569)2.47541814
153import into cell (GO:0098657)2.46894599
154regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.46692925
155regulation of complement activation (GO:0030449)2.46441796
156kynurenine metabolic process (GO:0070189)2.45429367
157regulation of lipoprotein particle clearance (GO:0010984)2.44533567
158leukocyte tethering or rolling (GO:0050901)2.44151230
159nucleotide-sugar biosynthetic process (GO:0009226)2.44143794
160leukocyte migration involved in inflammatory response (GO:0002523)2.43802704
161positive regulation of fatty acid beta-oxidation (GO:0032000)2.43772388
162cell-cell junction maintenance (GO:0045217)2.43451768
163protein localization to microtubule (GO:0035372)2.42977746
164negative regulation of blood coagulation (GO:0030195)2.42755477
165negative regulation of hemostasis (GO:1900047)2.42755477
166bone trabecula formation (GO:0060346)2.42754487
167negative regulation of chondrocyte differentiation (GO:0032331)2.41941838
168positive regulation of fatty acid oxidation (GO:0046321)2.41779220
169detection of mechanical stimulus involved in sensory perception (GO:0050974)2.40536741
170collagen fibril organization (GO:0030199)2.38917361
171bile acid biosynthetic process (GO:0006699)2.38774944
172regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.38025812
173regulation of axon guidance (GO:1902667)2.37047090
174vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36800361
175negative regulation of biomineral tissue development (GO:0070168)2.36327585
176potassium ion import (GO:0010107)2.34681793
177cranial nerve structural organization (GO:0021604)2.33760991
178brown fat cell differentiation (GO:0050873)2.33727399
179positive regulation of blood coagulation (GO:0030194)2.33173598
180positive regulation of hemostasis (GO:1900048)2.33173598
181negative regulation of wound healing (GO:0061045)2.31942850
182anatomical structure arrangement (GO:0048532)2.30851740
183cell differentiation involved in metanephros development (GO:0072202)2.29773975
184eyelid development in camera-type eye (GO:0061029)2.29435323
185regulation of axon extension involved in axon guidance (GO:0048841)2.29140535
186short-term memory (GO:0007614)2.28689685
187negative regulation of bone remodeling (GO:0046851)2.27988390
188protein activation cascade (GO:0072376)2.26858721
189acylglycerol homeostasis (GO:0055090)2.24535635
190triglyceride homeostasis (GO:0070328)2.24535635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.75023878
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17151884
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.14406208
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.04190163
5* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human3.03706486
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.03282657
7GBX2_23144817_ChIP-Seq_PC3_Human2.89149072
8EZH2_22144423_ChIP-Seq_EOC_Human2.88403205
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.78104493
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61905561
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60272417
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58602404
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52121692
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42913437
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42913437
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40375437
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38994490
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38627272
19BRD4_25478319_ChIP-Seq_HGPS_Human2.36882421
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33576916
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.30566142
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25904876
23P300_27058665_Chip-Seq_ZR-75-30cells_Human2.22408625
24AR_21572438_ChIP-Seq_LNCaP_Human2.20309792
25CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.17661916
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16974310
27JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12239641
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.09132884
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.07135050
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.04707465
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04516130
32MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01834382
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.98646195
34TAF15_26573619_Chip-Seq_HEK293_Human1.89951052
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89517383
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89149766
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86814339
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82534764
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81567673
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80604220
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.78229652
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78160312
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76877672
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75639069
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74640791
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.74212016
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.70987448
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.69599922
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.69484732
50TP53_16413492_ChIP-PET_HCT116_Human1.69178425
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68373424
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67193699
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67193699
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64823413
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64358401
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60942484
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.60420831
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60341612
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60136446
60DROSHA_22980978_ChIP-Seq_HELA_Human1.58423665
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55871329
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53639994
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.52021044
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50341565
65AR_21909140_ChIP-Seq_LNCAP_Human1.50222417
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46970678
67FUS_26573619_Chip-Seq_HEK293_Human1.43543210
68P300_19829295_ChIP-Seq_ESCs_Human1.42104299
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40948620
70TP53_22127205_ChIP-Seq_IMR90_Human1.40028946
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39327275
72ATF3_27146783_Chip-Seq_COLON_Human1.38853680
73DCP1A_22483619_ChIP-Seq_HELA_Human1.35745784
74* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35439798
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33969037
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33411471
77ELK1_19687146_ChIP-ChIP_HELA_Human1.33292379
78VDR_22108803_ChIP-Seq_LS180_Human1.32645323
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31348404
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30154506
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30154506
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.30085569
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28149020
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.27712817
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27392580
86ER_23166858_ChIP-Seq_MCF-7_Human1.27197937
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.26030045
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25560315
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.25527572
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.21944114
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21897546
92TP53_18474530_ChIP-ChIP_U2OS_Human1.21636276
93PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.21088945
94BCAT_22108803_ChIP-Seq_LS180_Human1.20169103
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20045975
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.19692557
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19624367
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.19579704
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19087415
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18352629
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18071013
102ZNF263_19887448_ChIP-Seq_K562_Human1.13890604
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13291974
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.12401944
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11719640
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11605298
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10401721
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.09976539
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09515395
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09392023
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.08241647
112* CJUN_26792858_Chip-Seq_BT549_Human1.08043867
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07808003
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07285844
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07198592
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06337518
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05544010
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03639970
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.03159852
120ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02822381
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02437756
122CLOCK_20551151_ChIP-Seq_293T_Human1.00379883
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.99796996
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99429870
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98743750
126SMAD4_21799915_ChIP-Seq_A2780_Human0.97899198
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97583014
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96766282
129RXR_22108803_ChIP-Seq_LS180_Human0.96538694
130NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96434495
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96319372
132AHR_22903824_ChIP-Seq_MCF-7_Human0.95907477
133* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95880620
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.93873070
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93786493
136FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93361471
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93143203
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92848558
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.92415935
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91720177
141SOX9_26525672_Chip-Seq_HEART_Mouse0.91510474
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90612967
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90486126
144FLI1_27457419_Chip-Seq_LIVER_Mouse0.90439388
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.89396660
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89209967
147TCF4_18268006_ChIP-ChIP_LS174T_Human0.89037652
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88494563
149JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88018319
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87945625
151VDR_24787735_ChIP-Seq_THP-1_Human0.87052606
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86870325
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86497488
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86199944
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86041911
156KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85066375
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85066375
158RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84791458
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.84368000
160NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84291255
161CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82724707
162TTF2_22483619_ChIP-Seq_HELA_Human0.81762530
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81130404
164EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80497829
165ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80420270
166ESRRB_18555785_Chip-Seq_ESCs_Mouse0.80353234
167REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79789439
168NFI_21473784_ChIP-Seq_ESCs_Mouse0.78575680
169SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.77973988
170CMYC_18555785_Chip-Seq_ESCs_Mouse0.77364696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system6.18318297
2MP0005171_absent_coat_pigmentation5.53432079
3MP0002254_reproductive_system_inflammat4.82166404
4MP0010368_abnormal_lymphatic_system4.79969895
5MP0006054_spinal_hemorrhage4.44018101
6MP0008004_abnormal_stomach_pH4.34532602
7MP0003724_increased_susceptibility_to4.33453879
8MP0008438_abnormal_cutaneous_collagen3.76834029
9MP0001879_abnormal_lymphatic_vessel3.24212592
10MP0000013_abnormal_adipose_tissue3.12427990
11MP0002822_catalepsy2.84897000
12MP0002139_abnormal_hepatobiliary_system2.83463258
13MP0002938_white_spotting2.48287491
14MP0001958_emphysema2.43387810
15MP0002876_abnormal_thyroid_physiology2.32285225
16MP0005623_abnormal_meninges_morphology2.29313410
17MP0005408_hypopigmentation2.28477589
18MP0003195_calcinosis2.18858205
19MP0010030_abnormal_orbit_morphology2.17840243
20MP0003950_abnormal_plasma_membrane2.07538942
21MP0002102_abnormal_ear_morphology1.98679868
22MP0004272_abnormal_basement_membrane1.97925085
23MP0002877_abnormal_melanocyte_morpholog1.94817298
24MP0005085_abnormal_gallbladder_physiolo1.82220024
25MP0001851_eye_inflammation1.81048169
26MP0005360_urolithiasis1.80298079
27MP0001346_abnormal_lacrimal_gland1.79992488
28MP0000462_abnormal_digestive_system1.76239102
29MP0003705_abnormal_hypodermis_morpholog1.74377284
30MP0005248_abnormal_Harderian_gland1.72471873
31MP0000566_synostosis1.59895462
32MP0005503_abnormal_tendon_morphology1.59279597
33MP0004742_abnormal_vestibular_system1.58928797
34MP0010386_abnormal_urinary_bladder1.50523132
35MP0005365_abnormal_bile_salt1.50112323
36MP0001299_abnormal_eye_distance/1.49695722
37MP0003385_abnormal_body_wall1.49143566
38MP0002896_abnormal_bone_mineralization1.48781290
39MP0001727_abnormal_embryo_implantation1.48660175
40MP0005275_abnormal_skin_tensile1.48525339
41MP0001501_abnormal_sleep_pattern1.42610462
42MP0002249_abnormal_larynx_morphology1.42530847
43MP0003300_gastrointestinal_ulcer1.42209035
44MP0001348_abnormal_lacrimal_gland1.40419712
45MP0003566_abnormal_cell_adhesion1.38587937
46MP0003091_abnormal_cell_migration1.37582773
47MP0005670_abnormal_white_adipose1.36210324
48MP0003634_abnormal_glial_cell1.36103206
49MP0000383_abnormal_hair_follicle1.34913573
50MP0005409_darkened_coat_color1.32413066
51MP0004215_abnormal_myocardial_fiber1.31643266
52MP0005645_abnormal_hypothalamus_physiol1.31495109
53MP0009780_abnormal_chondrocyte_physiolo1.31072967
54MP0005257_abnormal_intraocular_pressure1.31025673
55MP0004510_myositis1.30198815
56MP0009250_abnormal_appendicular_skeleto1.28479510
57MP0004859_abnormal_synaptic_plasticity1.25562340
58MP0005595_abnormal_vascular_smooth1.24112478
59MP0000003_abnormal_adipose_tissue1.22867362
60MP0008875_abnormal_xenobiotic_pharmacok1.20508626
61MP0002060_abnormal_skin_morphology1.19467984
62MP0000647_abnormal_sebaceous_gland1.17795841
63MP0000358_abnormal_cell_content/1.16695891
64MP0003279_aneurysm1.16357891
65MP0003303_peritoneal_inflammation1.16259133
66MP0004233_abnormal_muscle_weight1.16154387
67MP0010329_abnormal_lipoprotein_level1.14082648
68MP0005508_abnormal_skeleton_morphology1.09761430
69MP0005666_abnormal_adipose_tissue1.09531734
70MP0000049_abnormal_middle_ear1.09230006
71MP0009379_abnormal_foot_pigmentation1.09060432
72MP0001243_abnormal_dermal_layer1.08580047
73MP0005310_abnormal_salivary_gland1.07127324
74MP0005164_abnormal_response_to1.06531618
75MP0000920_abnormal_myelination1.06334423
76MP0001661_extended_life_span1.04650079
77MP0003329_amyloid_beta_deposits1.00739603
78MP0003942_abnormal_urinary_system1.00223156
79MP0000733_abnormal_muscle_development1.00210764
80MP0008874_decreased_physiological_sensi0.99717275
81MP0001502_abnormal_circadian_rhythm0.98888098
82MP0005075_abnormal_melanosome_morpholog0.98866946
83MP0000749_muscle_degeneration0.98334554
84MP0001542_abnormal_bone_strength0.97837360
85MP0010352_gastrointestinal_tract_polyps0.97028499
86MP0006276_abnormal_autonomic_nervous0.96908757
87MP0002971_abnormal_brown_adipose0.96545382
88MP0005375_adipose_tissue_phenotype0.94574251
89MP0005023_abnormal_wound_healing0.94021532
90MP0000534_abnormal_ureter_morphology0.91830904
91MP0003959_abnormal_lean_body0.91350429
92MP0002168_other_aberrant_phenotype0.91336450
93MP0008932_abnormal_embryonic_tissue0.89613835
94MP0004036_abnormal_muscle_relaxation0.89558736
95MP0004084_abnormal_cardiac_muscle0.89375168
96MP0002751_abnormal_autonomic_nervous0.89202156
97MP0002295_abnormal_pulmonary_circulatio0.84085604
98MP0005332_abnormal_amino_acid0.83809148
99MP0001533_abnormal_skeleton_physiology0.83385676
100MP0010678_abnormal_skin_adnexa0.83345272
101MP0001968_abnormal_touch/_nociception0.83015728
102MP0000432_abnormal_head_morphology0.82698944
103MP0009053_abnormal_anal_canal0.82512236
104MP0005367_renal/urinary_system_phenotyp0.82177361
105MP0000516_abnormal_urinary_system0.82177361
106MP0010771_integument_phenotype0.80004909
107MP0000467_abnormal_esophagus_morphology0.79446608
108MP0002735_abnormal_chemical_nociception0.79215908
109MP0004185_abnormal_adipocyte_glucose0.78901594
110MP0001440_abnormal_grooming_behavior0.78824318
111MP0005058_abnormal_lysosome_morphology0.78533857
112MP0004130_abnormal_muscle_cell0.76966771
113MP0001486_abnormal_startle_reflex0.76469223
114MP0000163_abnormal_cartilage_morphology0.76247220
115MP0002796_impaired_skin_barrier0.76047226
116MP0003690_abnormal_glial_cell0.74849601
117MP0002233_abnormal_nose_morphology0.71725567
118MP0009745_abnormal_behavioral_response0.71025642
119MP0004142_abnormal_muscle_tone0.70976718
120MP0005197_abnormal_uvea_morphology0.70578085
121MP0002115_abnormal_skeleton_extremities0.70561604
122MP0002177_abnormal_outer_ear0.70246574
123MP0003252_abnormal_bile_duct0.69839640
124MP0009046_muscle_twitch0.69393098
125MP0008007_abnormal_cellular_replicative0.68905376
126MP0003755_abnormal_palate_morphology0.68419043
127MP0002113_abnormal_skeleton_development0.68354087
128MP0005390_skeleton_phenotype0.68012041
129MP0009384_cardiac_valve_regurgitation0.67674907
130MP0008770_decreased_survivor_rate0.66317573
131MP0000681_abnormal_thyroid_gland0.65245656
132MP0002098_abnormal_vibrissa_morphology0.64657286
133MP0000751_myopathy0.64631697
134MP0000609_abnormal_liver_physiology0.64397275
135MP0002932_abnormal_joint_morphology0.64270179
136MP0002933_joint_inflammation0.63189427
137MP0003635_abnormal_synaptic_transmissio0.62644604
138MP0002116_abnormal_craniofacial_bone0.62544663
139MP0002736_abnormal_nociception_after0.62141429
140MP0000579_abnormal_nail_morphology0.62072281
141MP0002733_abnormal_thermal_nociception0.62028502
142MP0001756_abnormal_urination0.61286834
143MP0003937_abnormal_limbs/digits/tail_de0.60895008
144MP0001905_abnormal_dopamine_level0.60520098
145MP0002118_abnormal_lipid_homeostasis0.60352377
146MP0000762_abnormal_tongue_morphology0.60291424
147MP0002075_abnormal_coat/hair_pigmentati0.60156963
148MP0003938_abnormal_ear_development0.59373349
149MP0000639_abnormal_adrenal_gland0.58620995
150MP0005330_cardiomyopathy0.58615632
151MP0000569_abnormal_digit_pigmentation0.57190353
152MP0008775_abnormal_heart_ventricle0.56927293
153MP0003806_abnormal_nucleotide_metabolis0.56657210
154MP0001186_pigmentation_phenotype0.56257003
155MP0004381_abnormal_hair_follicle0.56238718
156MP0000759_abnormal_skeletal_muscle0.56055612
157MP0000747_muscle_weakness0.55826294
158MP0002269_muscular_atrophy0.54347555
159MP0001614_abnormal_blood_vessel0.54004512
160MP0005384_cellular_phenotype0.54003681
161MP0000427_abnormal_hair_cycle0.52331462
162MP0005621_abnormal_cell_physiology0.51855321
163MP0005410_abnormal_fertilization0.51789729
164MP0002114_abnormal_axial_skeleton0.51215680
165MP0002108_abnormal_muscle_morphology0.50314392

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)7.06541178
2Premature rupture of membranes (HP:0001788)6.04485415
3Hand muscle atrophy (HP:0009130)5.54820405
4Protrusio acetabuli (HP:0003179)5.12466115
5Peripheral hypomyelination (HP:0007182)4.99526956
6Deep venous thrombosis (HP:0002625)4.94301487
7Distal upper limb amyotrophy (HP:0007149)4.57275061
8Upper limb amyotrophy (HP:0009129)4.57275061
9Abnormality of the distal phalanges of the toes (HP:0010182)4.55788347
10Absent eyelashes (HP:0000561)4.42983256
11Limb-girdle muscle atrophy (HP:0003797)4.09365527
12Broad metatarsal (HP:0001783)3.94487194
13White forelock (HP:0002211)3.88074972
14Patchy hypopigmentation of hair (HP:0011365)3.84684532
15Short nail (HP:0001799)3.84214451
16Hypoplastic ischia (HP:0003175)3.74460325
17Ankle contracture (HP:0006466)3.71346174
18Short hallux (HP:0010109)3.68001994
19Atrophic scars (HP:0001075)3.66880385
20Prolonged partial thromboplastin time (HP:0003645)3.58159764
21Abnormality of the ischium (HP:0003174)3.51161756
22Spinal rigidity (HP:0003306)3.41420000
23Distal lower limb muscle weakness (HP:0009053)3.39228287
24Sparse lateral eyebrow (HP:0005338)3.38593202
25Heterochromia iridis (HP:0001100)3.25393346
26Aplasia/Hypoplasia of the hallux (HP:0008362)3.22925308
27Hypoalphalipoproteinemia (HP:0003233)3.19708181
28Elbow flexion contracture (HP:0002987)3.19680066
29Abnormal auditory evoked potentials (HP:0006958)3.13891383
30Venous abnormality (HP:0002624)3.12356886
31Termporal pattern (HP:0011008)3.08549777
32Insidious onset (HP:0003587)3.08549777
33Peritonitis (HP:0002586)3.05690592
34Coronal craniosynostosis (HP:0004440)3.05517466
35Osteolytic defects of the hand bones (HP:0009699)3.05405635
36Osteolytic defects of the phalanges of the hand (HP:0009771)3.05405635
37Spinal cord compression (HP:0002176)2.98245296
38Focal motor seizures (HP:0011153)2.97342689
39Intrahepatic cholestasis (HP:0001406)2.96189419
40Shallow orbits (HP:0000586)2.94265161
41Abnormality of dentin (HP:0010299)2.91629672
42Upper limb muscle weakness (HP:0003484)2.89500462
43Aplasia cutis congenita (HP:0001057)2.89395159
44Venous insufficiency (HP:0005293)2.87909605
45Neonatal short-limb short stature (HP:0008921)2.84188943
46Congenital, generalized hypertrichosis (HP:0004540)2.83966504
47Vascular calcification (HP:0004934)2.83568344
48Morphological abnormality of the middle ear (HP:0008609)2.81084656
49Cardiovascular calcification (HP:0011915)2.80641074
50Stridor (HP:0010307)2.80072773
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77327741
52Hyperlipoproteinemia (HP:0010980)2.74206287
53Aplasia of the musculature (HP:0100854)2.73150895
54Wormian bones (HP:0002645)2.72002941
55Hypoventilation (HP:0002791)2.69788046
56Soft skin (HP:0000977)2.68315966
57Limb-girdle muscle weakness (HP:0003325)2.59918325
58Capillary hemangiomas (HP:0005306)2.55387712
59Partial duplication of the phalanx of hand (HP:0009999)2.50057456
60Hypolipoproteinemia (HP:0010981)2.46624182
61Achilles tendon contracture (HP:0001771)2.45502733
62Absent hair (HP:0002298)2.45485634
63Hydroxyprolinuria (HP:0003080)2.45153386
64Abnormality of proline metabolism (HP:0010907)2.45153386
65Hammertoe (HP:0001765)2.44642157
66Xanthomatosis (HP:0000991)2.43034725
67Small epiphyses (HP:0010585)2.42945145
68Coxa vara (HP:0002812)2.40041043
69Nuclear cataract (HP:0100018)2.39297198
70Action tremor (HP:0002345)2.38900524
71Joint hemorrhage (HP:0005261)2.38859252
72Abnormality of the intrinsic pathway (HP:0010989)2.38802700
73Chin dimple (HP:0010751)2.37218557
74Follicular hyperkeratosis (HP:0007502)2.36302345
75Abnormality of the peritoneum (HP:0002585)2.34667416
76Infantile muscular hypotonia (HP:0008947)2.34269305
77Entropion (HP:0000621)2.33832002
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33339264
79Abnormal delivery (HP:0001787)2.32394009
80Increased connective tissue (HP:0009025)2.32333113
81Generalized amyotrophy (HP:0003700)2.31112670
82Hypoplasia of the iris (HP:0007676)2.29931427
83Biconcave vertebral bodies (HP:0004586)2.29848107
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28646230
85Rough bone trabeculation (HP:0100670)2.28180664
86Spastic paraparesis (HP:0002313)2.28120253
87Long toe (HP:0010511)2.27138457
88Abnormality of the umbilical cord (HP:0010881)2.26432262
89Blue irides (HP:0000635)2.25942887
90Shoulder girdle muscle weakness (HP:0003547)2.25705422
91Abnormality of the 2nd finger (HP:0004100)2.25057785
92Down-sloping shoulders (HP:0200021)2.24320321
93Osteomalacia (HP:0002749)2.23183686
94Vertebral compression fractures (HP:0002953)2.22419042
95Aplasia involving bones of the extremities (HP:0009825)2.21590157
96Aplasia involving bones of the upper limbs (HP:0009823)2.21590157
97Aplasia of the phalanges of the hand (HP:0009802)2.21590157
98Myocardial infarction (HP:0001658)2.20451281
99Aortic dissection (HP:0002647)2.19537318
100Right ventricular cardiomyopathy (HP:0011663)2.19391970
101Preaxial foot polydactyly (HP:0001841)2.18354370
102Tibial bowing (HP:0002982)2.17297275
103Chronic mucocutaneous candidiasis (HP:0002728)2.16357545
104Recurrent cutaneous fungal infections (HP:0011370)2.16357545
105Alopecia of scalp (HP:0002293)2.16114606
106Fragile skin (HP:0001030)2.15835718
107Mildly elevated creatine phosphokinase (HP:0008180)2.14668469
108Blue sclerae (HP:0000592)2.14330449
109Cervical subluxation (HP:0003308)2.13556448
110Wide anterior fontanel (HP:0000260)2.12881197
111Epiphyseal dysplasia (HP:0002656)2.11777536
112Abnormality of the Achilles tendon (HP:0005109)2.11092293
113Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10974925
114Delayed cranial suture closure (HP:0000270)2.09753945
115Hyperglycemia (HP:0003074)2.09718868
116Knee flexion contracture (HP:0006380)2.07708151
117Difficulty climbing stairs (HP:0003551)2.07598521
118Fetal akinesia sequence (HP:0001989)2.06252783
119Mitral stenosis (HP:0001718)2.03417585
120Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03201580
121Abnormality of the middle phalanges of the toes (HP:0010183)2.02950802
122Abnormality of the nasolacrimal system (HP:0000614)2.02676392
123Abnormality of carpal bone ossification (HP:0006257)2.02516617
124Alacrima (HP:0000522)2.01826196
125Natal tooth (HP:0000695)2.01027566
126Distal lower limb amyotrophy (HP:0008944)2.00685785
127Cerebral hypomyelination (HP:0006808)2.00319961
128Ulnar bowing (HP:0003031)2.00069213
129J-shaped sella turcica (HP:0002680)1.99875607
130Cerebral inclusion bodies (HP:0100314)1.99750934
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.99050722
132Fibular aplasia (HP:0002990)1.97515431
133Reduced subcutaneous adipose tissue (HP:0003758)1.97445979
134Neurofibrillary tangles (HP:0002185)1.96867252
135Ulnar claw (HP:0001178)1.96839409
136Lymphedema (HP:0001004)1.95831146
137Synostosis involving the elbow (HP:0003938)1.95196641
138Humeroradial synostosis (HP:0003041)1.95196641
139Abnormality of the musculature of the pelvis (HP:0001469)1.95024014
140Abnormality of the hip-girdle musculature (HP:0001445)1.95024014
141Mild short stature (HP:0003502)1.93104349
142Vascular tortuosity (HP:0004948)1.90452563
143Abnormal autonomic nervous system physiology (HP:0012332)1.90352178
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.89558859
145Obstructive sleep apnea (HP:0002870)1.89479102
146Narrow nasal bridge (HP:0000446)1.89389780
147Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88764867
148Flat acetabular roof (HP:0003180)1.88457539
149Premature graying of hair (HP:0002216)1.88416830
150Decreased skull ossification (HP:0004331)1.87270081
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86808253
152Absent epiphyses (HP:0010577)1.86808253
153Generalized tonic-clonic seizures (HP:0002069)1.85604108
154Spinal muscular atrophy (HP:0007269)1.84932041
155Slender build (HP:0001533)1.84532794
156Amyloidosis (HP:0011034)1.83791874
157Abnormality of skull ossification (HP:0002703)1.83285030
158Nasolacrimal duct obstruction (HP:0000579)1.82500935
159Complement deficiency (HP:0004431)1.81718697
160Hypobetalipoproteinemia (HP:0003563)1.81677442
161Foot dorsiflexor weakness (HP:0009027)1.80977465
162Prominent supraorbital ridges (HP:0000336)1.80891189
163Buphthalmos (HP:0000557)1.80608277
164Abnormality of the acetabulum (HP:0003170)1.79765037
165Cerebral aneurysm (HP:0004944)1.78900302
166Abnormal pupillary function (HP:0007686)1.78563497
167Asymmetry of the thorax (HP:0001555)1.78480580
168Palpebral edema (HP:0100540)1.78403279
169Spondylolisthesis (HP:0003302)1.78126838
170Arterial tortuosity (HP:0005116)1.77992766
171Genu recurvatum (HP:0002816)1.77647013
172Bladder diverticulum (HP:0000015)1.76839971
173Dislocated radial head (HP:0003083)1.76558665
174Scapular winging (HP:0003691)1.75250927
175Lip pit (HP:0100267)1.74475864
176Bronchomalacia (HP:0002780)1.74324328
177Ectopia lentis (HP:0001083)1.73598449
178Turricephaly (HP:0000262)1.73332092
179Seborrheic dermatitis (HP:0001051)1.73265160
180Distal sensory impairment (HP:0002936)1.73116360
181Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73094140
182Mitral regurgitation (HP:0001653)1.72602660
183Glucose intolerance (HP:0000833)1.72562183
184Abnormality of the vocal cords (HP:0008777)1.71150702
185Absent eyebrow (HP:0002223)1.71108871
186Abnormality of the musculature of the hand (HP:0001421)1.70103291
187Abnormality of the radial head (HP:0003995)1.69511222
188Autoamputation (HP:0001218)1.69356293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR8.80338863
2LMTK26.95460525
3TIE14.06124116
4BLK3.66845306
5NME22.95930147
6PHKG12.53072176
7PHKG22.53072176
8TESK12.40875428
9MST1R2.32897244
10PAK62.32479846
11PNCK2.15488057
12LIMK12.12720688
13EPHA22.07183411
14NTRK12.07018441
15GRK12.03869664
16EPHB21.99006631
17MOS1.95322894
18INSRR1.85066848
19IRAK31.80313045
20FLT31.74405515
21ERBB31.72548719
22CDK81.69997826
23MAP2K71.69244499
24EPHA41.68893309
25CASK1.59635213
26FER1.56908391
27TGFBR21.56562293
28EPHA31.48899944
29JAK11.47125621
30NTRK31.45403735
31GRK71.45176717
32SIK11.44704014
33PRKD31.42624093
34BRSK11.35056498
35PAK21.29831105
36WNK11.27959352
37PDGFRB1.27541561
38NTRK21.24628365
39PTK21.22635126
40ERBB41.21745161
41PDGFRA1.20682570
42DDR21.20463560
43SIK31.19873266
44PIK3CA1.16319587
45CDK91.16062633
46LATS21.15518364
47ARAF1.12745971
48LATS11.12404112
49TGFBR11.02173481
50PTK2B1.01754347
51MAP3K140.99228100
52PTK60.99122633
53NEK60.98275530
54BUB10.96727784
55MAP3K130.93992639
56MAP3K40.93180143
57EPHB10.92619444
58PRKD20.92169212
59TSSK60.91674704
60TNIK0.91522575
61MAP2K40.91331582
62AKT30.89005062
63FGR0.88946021
64CAMK2A0.86441448
65PLK20.85883254
66MAPK150.85602479
67RET0.84984533
68BCR0.84663615
69FGFR20.84308100
70TAOK20.83542525
71DMPK0.80679875
72FGFR40.78567391
73SIK20.77787709
74ROCK20.77619888
75ADRBK20.77213872
76MKNK20.74679005
77NEK10.74608906
78BMX0.74419995
79STK380.74366496
80MAP3K30.73690332
81IRAK20.73458507
82ERN10.72764488
83PRKAA20.72426526
84MET0.72212266
85DAPK20.71827927
86SCYL20.71086817
87STK38L0.70396772
88ABL20.69906844
89ADRBK10.69547703
90JAK20.68452196
91CAMK40.67527474
92STK30.66131133
93PKN10.63108935
94FRK0.62157549
95CAMK2D0.60674001
96MAPKAPK50.60641802
97CDK180.59402264
98MAP3K60.58270550
99CLK10.57709361
100CDK150.57469041
101CDK11A0.57356777
102CDK120.57306754
103JAK30.56696096
104CDC42BPA0.56480346
105CDK140.55446905
106BMPR1B0.53198257
107CAMKK20.51813934
108FES0.51219103
109CAMK2B0.50834587
110TEC0.50543194
111PRKCE0.50406154
112GRK50.49726110
113ERBB20.49358639
114NEK90.49338585
115SRC0.48926133
116EIF2AK20.48858139
117IRAK10.48713280
118MAP2K10.46944525
119PAK30.42857604
120TTN0.42633524
121MAP3K90.42616704
122INSR0.42426037
123GSK3A0.42407540
124BRSK20.42235018
125BRAF0.40758402
126ZAP700.39856097
127ROCK10.39582968
128DYRK30.39018421
129CDK30.37639650
130EIF2AK30.37436511
131STK390.37414035
132KSR10.37356249
133NUAK10.36960465
134PAK10.36814552
135MAP4K20.36167953
136PDPK10.35919693
137PBK0.35711985
138CDK50.35251867
139DYRK1B0.35032278
140TYK20.34704980
141YES10.34617505
142NME10.34011353
143PAK40.33581456
144BRD40.33214801
145UHMK10.32488962
146BMPR20.31938773
147AURKA0.31577432
148MINK10.31196477
149MARK10.30190394
150AKT20.29741589
151TESK20.28607862
152ILK0.25946058
153MAP3K80.25885586
154WEE10.24043590
155PLK10.21135834
156MAP3K120.20284394
157NEK20.17288517
158MTOR0.15183547
159TTK0.14406084

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.96193525
2Complement and coagulation cascades_Homo sapiens_hsa046102.81047451
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66712798
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.43830913
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40522280
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.31488475
7Malaria_Homo sapiens_hsa051442.26068547
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.18403252
9N-Glycan biosynthesis_Homo sapiens_hsa005102.05851750
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95686133
11Protein export_Homo sapiens_hsa030601.91356530
12Proteasome_Homo sapiens_hsa030501.90645279
13Vibrio cholerae infection_Homo sapiens_hsa051101.88202102
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85619215
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83817371
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82869492
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.80016847
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.79515940
19Nitrogen metabolism_Homo sapiens_hsa009101.77716285
20Staphylococcus aureus infection_Homo sapiens_hsa051501.77208857
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75421497
22African trypanosomiasis_Homo sapiens_hsa051431.74630783
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74412114
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73061372
25Nicotine addiction_Homo sapiens_hsa050331.72809072
26Protein digestion and absorption_Homo sapiens_hsa049741.64058857
27Tryptophan metabolism_Homo sapiens_hsa003801.63160689
28Arginine biosynthesis_Homo sapiens_hsa002201.63060797
29Butanoate metabolism_Homo sapiens_hsa006501.62843318
30Chemical carcinogenesis_Homo sapiens_hsa052041.62402841
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60325786
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59502731
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59431672
34PPAR signaling pathway_Homo sapiens_hsa033201.54213760
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.54178947
36Sulfur relay system_Homo sapiens_hsa041221.50990401
37Histidine metabolism_Homo sapiens_hsa003401.49221656
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46193658
39ECM-receptor interaction_Homo sapiens_hsa045121.42861129
40Phenylalanine metabolism_Homo sapiens_hsa003601.42735685
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42546300
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38413465
43Other glycan degradation_Homo sapiens_hsa005111.34229131
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30543663
45Hedgehog signaling pathway_Homo sapiens_hsa043401.29888617
46Circadian rhythm_Homo sapiens_hsa047101.27715283
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27297750
48Small cell lung cancer_Homo sapiens_hsa052221.26925672
49Biosynthesis of amino acids_Homo sapiens_hsa012301.26776314
50Bile secretion_Homo sapiens_hsa049761.25392640
51Melanoma_Homo sapiens_hsa052181.23959386
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23296302
53Taste transduction_Homo sapiens_hsa047421.18077015
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17352286
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16721626
56ABC transporters_Homo sapiens_hsa020101.14563861
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13113989
58Vitamin digestion and absorption_Homo sapiens_hsa049771.10939003
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10642731
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10354490
61Axon guidance_Homo sapiens_hsa043601.09988190
62Tyrosine metabolism_Homo sapiens_hsa003501.09786754
63Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06435356
64beta-Alanine metabolism_Homo sapiens_hsa004101.05761509
65Serotonergic synapse_Homo sapiens_hsa047261.04842230
66Carbon metabolism_Homo sapiens_hsa012001.03325377
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99802138
68MicroRNAs in cancer_Homo sapiens_hsa052060.99194506
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98756208
70Sulfur metabolism_Homo sapiens_hsa009200.98475290
71Vitamin B6 metabolism_Homo sapiens_hsa007500.97882770
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97829678
73Hippo signaling pathway_Homo sapiens_hsa043900.96119521
74Ras signaling pathway_Homo sapiens_hsa040140.94445338
75Retinol metabolism_Homo sapiens_hsa008300.93149918
76Ovarian steroidogenesis_Homo sapiens_hsa049130.91663229
77Arginine and proline metabolism_Homo sapiens_hsa003300.91145300
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.90812005
79Pentose phosphate pathway_Homo sapiens_hsa000300.90089774
80Nucleotide excision repair_Homo sapiens_hsa034200.89545955
81Synaptic vesicle cycle_Homo sapiens_hsa047210.88951796
82Fatty acid degradation_Homo sapiens_hsa000710.88470725
83Fatty acid elongation_Homo sapiens_hsa000620.87741645
84Folate biosynthesis_Homo sapiens_hsa007900.87668635
85GABAergic synapse_Homo sapiens_hsa047270.87655065
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87303219
87Peroxisome_Homo sapiens_hsa041460.86571485
88Adherens junction_Homo sapiens_hsa045200.84383011
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82242331
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81372122
91Selenocompound metabolism_Homo sapiens_hsa004500.80660179
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78924246
93Fructose and mannose metabolism_Homo sapiens_hsa000510.77983177
94Glutamatergic synapse_Homo sapiens_hsa047240.76850172
95Fatty acid metabolism_Homo sapiens_hsa012120.75693389
96Sphingolipid metabolism_Homo sapiens_hsa006000.75033072
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74137352
98Rap1 signaling pathway_Homo sapiens_hsa040150.71862600
99Focal adhesion_Homo sapiens_hsa045100.71779946
100Linoleic acid metabolism_Homo sapiens_hsa005910.70879211
101Bladder cancer_Homo sapiens_hsa052190.70030078
102TNF signaling pathway_Homo sapiens_hsa046680.69395224
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68686762
104Morphine addiction_Homo sapiens_hsa050320.68633509
105Endocytosis_Homo sapiens_hsa041440.67571189
106Renal cell carcinoma_Homo sapiens_hsa052110.66986757
107Basal cell carcinoma_Homo sapiens_hsa052170.65258123
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64898756
109Lysine degradation_Homo sapiens_hsa003100.64701472
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64628629
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64362778
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63845774
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62192955
114Propanoate metabolism_Homo sapiens_hsa006400.61539215
115Phagosome_Homo sapiens_hsa041450.60580092
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60317936
117Arachidonic acid metabolism_Homo sapiens_hsa005900.60211431
118Amoebiasis_Homo sapiens_hsa051460.59487767
119Rheumatoid arthritis_Homo sapiens_hsa053230.59418486
120Pathways in cancer_Homo sapiens_hsa052000.59153356
121p53 signaling pathway_Homo sapiens_hsa041150.56882032
122Starch and sucrose metabolism_Homo sapiens_hsa005000.56669932
123Galactose metabolism_Homo sapiens_hsa000520.56052745
124Gap junction_Homo sapiens_hsa045400.56017582
125Pyrimidine metabolism_Homo sapiens_hsa002400.55376899
126ErbB signaling pathway_Homo sapiens_hsa040120.53512375
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52998590
128Cocaine addiction_Homo sapiens_hsa050300.52939068
129Lysosome_Homo sapiens_hsa041420.51760544
130Salivary secretion_Homo sapiens_hsa049700.51257070
131Fat digestion and absorption_Homo sapiens_hsa049750.48922149
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48856390
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48148536
134Collecting duct acid secretion_Homo sapiens_hsa049660.47635003
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46064327
136Ether lipid metabolism_Homo sapiens_hsa005650.45436830
137mTOR signaling pathway_Homo sapiens_hsa041500.45024346
138Fatty acid biosynthesis_Homo sapiens_hsa000610.44774276
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43756854
140Amphetamine addiction_Homo sapiens_hsa050310.43087851
141HIF-1 signaling pathway_Homo sapiens_hsa040660.41191230
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41190135
143Calcium signaling pathway_Homo sapiens_hsa040200.40252919
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40029118
145Long-term depression_Homo sapiens_hsa047300.39920552
146RNA transport_Homo sapiens_hsa030130.39553536
147Prion diseases_Homo sapiens_hsa050200.39196096
148Melanogenesis_Homo sapiens_hsa049160.39061364
149Type II diabetes mellitus_Homo sapiens_hsa049300.38920034
150Glutathione metabolism_Homo sapiens_hsa004800.37821213
151Shigellosis_Homo sapiens_hsa051310.37688348
152Wnt signaling pathway_Homo sapiens_hsa043100.37434394
153Pyruvate metabolism_Homo sapiens_hsa006200.37176391
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36765394
155Gastric acid secretion_Homo sapiens_hsa049710.34946320
156Caffeine metabolism_Homo sapiens_hsa002320.33579095
157Glioma_Homo sapiens_hsa052140.33575804
158TGF-beta signaling pathway_Homo sapiens_hsa043500.33364843
159Estrogen signaling pathway_Homo sapiens_hsa049150.32266073
160Fanconi anemia pathway_Homo sapiens_hsa034600.31085285
161Proteoglycans in cancer_Homo sapiens_hsa052050.30679382
162Dilated cardiomyopathy_Homo sapiens_hsa054140.30545424
163Steroid biosynthesis_Homo sapiens_hsa001000.29522414
164RNA polymerase_Homo sapiens_hsa030200.29477870
165Salmonella infection_Homo sapiens_hsa051320.29288718
166Tight junction_Homo sapiens_hsa045300.29128675
167Cysteine and methionine metabolism_Homo sapiens_hsa002700.28512930
168Metabolic pathways_Homo sapiens_hsa011000.28250263

Most similar genes based on co-expression Upload to Enrichr

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